Gonadotropin-Releasing Hormone Receptor Type II

Image from: Pawson, A., Maudsley, S., Morgan, K., Davidson, L., Naor, Z. and Millar, R. (2005). Inhibition of Human Type I Gonadotropin-Releasing Hormone Receptor (GnRHR) Function by Expression of a Human Type II GnRHR Gene Fragment. Endocrinology, [online] 146(6), pp.2639-2649. Available at: https://www.ncbi.nlm.nih.gov/pubmed/15761034 [Accessed 7 Mar. 2020]. It depicts the GnRHR Type II coding region with the exons as blank boxes, TMD as numbered boxes, with an N (left) and C (right) terminal at either end. It illustrates the frameshift (FS) mutation and START codon 117 bp further downstream.

The GnRH Type II receptor exists but appears to be inactive (Pawson et al., 2005). It has an early STOP codon as it has been moved via a frameshift mutation (Pawson et al., 2005). This allows the assumption that the receptor is not translated from this code (Pawson et al., 2005). However, it shows alternative splicing and is still able to under-go transcription (Pawson et al., 2005). It has a START codon over 100 base pairs down from this early STOP codon which can encode a protein and appears within the cytoplasm (Pawson et al., 2005).

References: PAWSON, A.J., MAUDSLEY, S., MORGAN, K., DAVIDSON, L., NAOR, Z. & MILLAR, R.P., 2005. Inhibition of Human Type I Gonadotropin-Releasing Hormone Receptor (GnRHR) Function by Expression of a Human Type II GnRHR Gene Fragment. Endocrinology. 146(6), pp.2639-2649. Available from: 10.1210/en.2005-0133.