code written: 2020-01-14
last ran: 2020-01-17
website: http://rpubs.com/navona/SPINS_sampleCharacteristics
Note: The neurocognition, social cognition, and negative symptom variables (that will be included in the CCA) include imputed values (see http://rpubs.com/navona/thesis_dataInterpolation for imputation via MICE). All other variables are observed values (and thus contain some missing values). This summary includes data from all participants eligible for the study (n=422), minus those who failed MRI QC (remaining n=412), and those who had some predetermined amount of tracts fail to segment (remaining n=390), and are thus will be excluded from the CCA analysis. We also show a separate table for the subset of participants scanned on a PRISMA scanner (n=162).
| Combined, n=390 | HC, n=162 | SSD, n=228 | p | |
|---|---|---|---|---|
| Demographics | ||||
| Sex (F:M) | 142:248 | 74:88 | 68:160 | .002 |
| Age (years) | 31.75 (9.99) | 31.94 (10.35) | 31.62 (9.75) | .751 |
| Handedness (0=L, 1=R) | 0.65 (0.47) | 0.63 (0.48) | 0.67 (0.46) | .437 |
| Education (years) | 14.52 (2.33) | 15.77 (1.99) | 13.62 (2.13) | .000 |
| BMI | 27.43 (5.73) | 25.86 (5.44) | 28.57 (5.67) | .000 |
| WTAR | 109.48 (13.56) | 113.69 (11.19) | 106.49 (14.31) | .000 |
| Neurocognition (MATRICS MCCB) | ||||
| Processing speed | 45.47 (13.49) | 53.38 (9.91) | 39.86 (12.88) | .000 |
| Attention and vigilance | 43.27 (12.43) | 48.14 (11.97) | 39.82 (11.60) | .000 |
| Working memory | 44.57 (11.79) | 49.15 (11.26) | 41.31 (11.07) | .000 |
| Verbal learning | 44.55 (10.25) | 50.13 (9.31) | 40.59 (8.99) | .000 |
| Visual learning | 43.34 (12.29) | 48.62 (10.12) | 39.58 (12.34) | .000 |
| Reasoning and problem solving | 45.45 (10.74) | 48.88 (9.47) | 43.01 (10.93) | .000 |
| Social cognition | ||||
| ER-40 | 2140.12 (677.57) | 1817.19 (376.01) | 2369.57 (747.78) | .000 |
| RMET | 25.83 (4.92) | 27.59 (3.87) | 24.58 (5.20) | .000 |
| EA | 0.48 (0.17) | 0.55 (0.14) | 0.43 (0.18) | .000 |
| RAD | 55.63 (9.12) | 60.54 (5.81) | 52.14 (9.45) | .000 |
| IRI | 67.92 (12.88) | 67.93 (11.56) | 67.91 (13.77) | .988 |
| TASIT 1 | 23.42 (3.24) | 24.60 (2.17) | 22.57 (3.60) | .000 |
| TASIT 2 | 50.41 (7.89) | 54.49 (4.38) | 47.50 (8.52) | .000 |
| TASIT 3 | 50.90 (7.69) | 54.81 (5.26) | 48.12 (7.93) | .000 |
| MRI | ||||
| Absolute motion | 0.53 (0.36) | 0.53 (0.38) | 0.52 (0.36) | .737 |
| Whole brain fractional anisotropy (FA) | 0.39 (0.02) | 0.39 (0.02) | 0.39 (0.02) | .509 |
| Clinical, functional, outcome | ||||
| SPQ-B | 6.15 (5.69) | 1.88 (2.55) | 9.20 (5.33) | .000 |
| CIRG-S | 2.66 (2.67) | 1.56 (1.70) | 3.45 (2.94) | .000 |
| BPRS | – | – | 31.11 (7.56) | – |
| SAS | – | – | 2.19 (2.38) | – |
| QLS | – | – | 73.77 (20.47) | – |
| SANS | – | – | 24.63 (11.94) | – |
| Medication | ||||
| CPZE equivalents (mg / day) | – | – | 509.63 (386.46) | – |
| Combined, n=162 | HC, n=78 | SSD, n=84 | p | |
|---|---|---|---|---|
| Demographics | ||||
| Sex (F:M) | 63:99 | 39:39 | 24:60 | .008 |
| Age (years) | 32.19 (10.03) | 33.17 (10.37) | 31.29 (9.68) | .234 |
| Handedness (0=L, 1=R) | 0.67 (0.45) | 0.62 (0.50) | 0.72 (0.39) | .176 |
| Education (years) | 15.05 (2.35) | 16.15 (2.08) | 14.02 (2.11) | .000 |
| BMI | 27.60 (5.55) | 26.69 (5.72) | 28.44 (5.29) | .045 |
| WTAR | 109.36 (13.19) | 113.03 (11.13) | 105.95 (14.07) | .001 |
| Neurocognition (MATRICS MCCB) | ||||
| Processing speed | 45.93 (14.50) | 54.27 (9.82) | 38.19 (13.88) | .000 |
| Attention and vigilance | 44.28 (14.01) | 48.44 (14.45) | 40.43 (12.48) | .000 |
| Working memory | 44.37 (11.59) | 46.64 (12.16) | 42.26 (10.68) | .016 |
| Verbal learning | 45.34 (11.35) | 50.99 (10.59) | 40.10 (9.39) | .000 |
| Visual learning | 42.62 (13.25) | 48.13 (11.45) | 37.51 (12.82) | .000 |
| Reasoning and problem solving | 46.42 (11.65) | 49.55 (10.09) | 43.51 (12.29) | .001 |
| Social cognition | ||||
| ER-40 | 2096.34 (560.71) | 1850.62 (368.08) | 2324.51 (612.15) | .000 |
| RMET | 25.71 (5.12) | 27.10 (4.16) | 24.42 (5.60) | .001 |
| EA | 0.47 (0.18) | 0.53 (0.16) | 0.41 (0.19) | .000 |
| RAD | 56.04 (8.45) | 60.36 (5.59) | 52.02 (8.70) | .000 |
| IRI | 66.51 (12.38) | 65.76 (11.69) | 67.21 (13.01) | .455 |
| TASIT 1 | 23.41 (3.16) | 24.78 (2.27) | 22.14 (3.35) | .000 |
| TASIT 2 | 50.75 (7.73) | 54.51 (4.40) | 47.25 (8.49) | .000 |
| TASIT 3 | 50.94 (8.23) | 54.31 (5.16) | 47.82 (9.28) | .000 |
| MRI | ||||
| Absolute motion | 0.49 (0.41) | 0.50 (0.43) | 0.48 (0.40) | .755 |
| Whole brain fractional anisotropy (FA) | 0.37 (0.01) | 0.38 (0.01) | 0.37 (0.01) | .002 |
| Clinical, functional, outcome | ||||
| SPQ-B | 5.11 (5.56) | 1.47 (2.52) | 8.49 (5.48) | .000 |
| CIRG-S | 2.81 (3.00) | 1.59 (2.00) | 3.95 (3.31) | .000 |
| BPRS | – | – | 31.18 (7.82) | – |
| SAS | – | – | 2.21 (2.6) | – |
| QLS | – | – | 69.96 (20.23) | – |
| SANS | – | – | 24.88 (11.67) | – |
| Medication | ||||
| CPZE equivalents (mg / day) | – | – | 556.35 (450.68) | – |