SPINS calculation of CPZE
using chlorpromazineR package
chlorpromazineR packagecode written: 2020-01-08
last ran: 2020-01-12
website: http://rpubs.com/navona/SPINS_CPZE
Description. Here, I convert the cleaned SPINS psychotropic medication data to CPZE (see http://rpubs.com/navona/SPINS_medications for dataset description). The CPZE conversion is consistent with Leucht (2016).
Software. chlorpromazineR | package PDF | documentation
Notes. The chlorpromazineR package allows for distinction between oral and depot, which I have made use of. The package additionally allows for further distinction between LAI and SAI depots, which I have not distinguished between (I assume all depots are LAI, as do the package defaults). Note also that the package allows for conversion to another antipsychotic equivalent, if preferred.
Summary table.
| medication name | method | participant count | CPZE conversion factor | mean CPZE | minimum CPZE | maximum CPZE | standard deviation CPZE |
|---|---|---|---|---|---|---|---|
| aripiprazole | depot | 12 | 20.000 | 261.905 | 142.857 | 285.714 | 46.524 |
| aripiprazole | oral | 32 | 20.000 | 291.562 | 100.000 | 800.000 | 167.662 |
| clozapine | oral | 61 | 1.500 | 508.402 | 75.000 | 1200.000 | 273.564 |
| fluphenazine | depot | 6 | 336.000 | 808.133 | 600.000 | 1200.000 | 224.599 |
| fluphenazine | oral | 4 | 50.000 | 1250.000 | 1000.000 | 2000.000 | 500.000 |
| haloperidol | depot | 10 | 112.000 | 400.000 | 300.000 | 500.000 | 47.140 |
| haloperidol | oral | 4 | 60.000 | 330.000 | 120.000 | 600.000 | 198.997 |
| loxapine | oral | 3 | 10.000 | 800.000 | 300.000 | 1500.000 | 624.500 |
| lurasidone | oral | 10 | 5.000 | 270.000 | 100.000 | 500.000 | 125.167 |
| olanzapine | oral | 34 | 30.000 | 469.853 | 75.000 | 900.000 | 213.181 |
| paliperidone | depot | 15 | 120.482 | 562.823 | 322.719 | 860.585 | 159.019 |
| paliperidone | oral | 5 | 66.667 | 320.000 | 200.000 | 400.000 | 109.545 |
| perphenazine | oral | 5 | 20.000 | 280.000 | 40.000 | 400.000 | 138.564 |
| quetiapine | oral | 23 | 0.800 | 218.203 | 6.667 | 800.000 | 176.941 |
| risperidone | depot | 4 | 168.000 | 312.000 | 48.000 | 600.000 | 256.858 |
| risperidone | oral | 38 | 100.000 | 381.579 | 100.000 | 800.000 | 178.742 |
| thiothixene | oral | 2 | 20.000 | 200.000 | 200.000 | 200.000 | 0.000 |
| ziprasidone | oral | 6 | 3.750 | 262.500 | 75.000 | 750.000 | 249.875 |
Visualization.
Reference.
Leucht, S., Samara, M., Heres, S., & Davis, J. M. (2016). Dose Equivalents for Antipsychotic Drugs: The DDD Method. Schizophrenia Bulletin, 42(suppl_1), S90–S94. link