Distribution Of tumors

DIAGNOSIS column
MENINGIOMA 17(42.5)
SCHWANNOMA 8(20)
NEUROFIBROMA 7(17.5)
EPENDYMOMA 2(5)
NEUROENTERIC CYST 2(5)
PARAGANGLIOMA 2(5)
DERMOID CYST 1(2.5)
EPIDERMOID CYST 1(2.5)

SUMMARY TABLE ALL

Dependent: all all
AGE Mean (SD) 45.7 (19.3)
SEX FEMALE 22 (55.0)
MALE 18 (45.0)
SITE Cervical 8 (20.0)
Lumbar 6 (15.0)
Thoracic 18 (45.0)
Thoraco Lumbar 8 (20.0)
AXIAL Anterior 6 (15.0)
Posterolateral 8 (20.0)
Posterior 26 (65.0)
OCCUPANCY Mean (SD) 79.7 (5.4)
VAS0 4 2 (5.0)
6 20 (50.0)
8 7 (17.5)
10 11 (27.5)
VAS6W 2 10 (25.0)
4 21 (52.5)
6 9 (22.5)
VAS12W 1 1 (2.5)
2 6 (15.0)
3 19 (47.5)
4 7 (17.5)
5 7 (17.5)
VAS6M 2 22 (55.0)
4 18 (45.0)
FC0 2 7 (17.5)
3 15 (37.5)
4 18 (45.0)
FC6W 2 4 (10.0)
3 9 (22.5)
4 13 (32.5)
5 14 (35.0)
FC12W 2 2 (5.0)
3 3 (7.5)
4 24 (60.0)
5 9 (22.5)
6 2 (5.0)
FC6M 2 4 (10.0)
4 17 (42.5)
5 19 (47.5)
DURATION_OF_SYMPTOM Mean (SD) 7.7 (2.6)
tumor EPENDYMOMA 2 (5.0)
MENINGIOMA 17 (42.5)
NERVE SHEATH TUMOUR 15 (37.5)
OTHER 6 (15.0)
deltavas 2 2 (5.0)
4 27 (67.5)
6 11 (27.5)
deltaFC 0 6 (15.0)
1 28 (70.0)
2 6 (15.0)
tumorsa MENINGIOMA 17 (42.5)
NEUROFIBROMA 7 (17.5)
SCHWANNOMA 8 (20.0)
Other 8 (20.0)

SUMMARY TABLE BY TYPE OF TUMOUR

label levels MENINGIOMA NEUROFIBROMA Other SCHWANNOMA p
AGE Mean (SD) 53.4 (18.1) 46.6 (18.2) 24.9 (9.5) 49.2 (17.0) 0.001
SEX FEMALE 14 (82.4) 0 (0.0) 3 (37.5) 5 (62.5) 0.002
MALE 3 (17.6) 7 (100.0) 5 (62.5) 3 (37.5)
SITE Cervical 3 (17.6) 1 (14.3) 0 (0.0) 4 (50.0) 0.003
Lumbar 0 (0.0) 0 (0.0) 4 (50.0) 2 (25.0)
Thoracic 11 (64.7) 2 (28.6) 3 (37.5) 2 (25.0)
Thoraco Lumbar 3 (17.6) 4 (57.1) 1 (12.5) 0 (0.0)
AXIAL Anterior 4 (23.5) 0 (0.0) 2 (25.0) 0 (0.0) 0.386
Posterolateral 4 (23.5) 2 (28.6) 0 (0.0) 2 (25.0)
Posterior 9 (52.9) 5 (71.4) 6 (75.0) 6 (75.0)
OCCUPANCY Mean (SD) 80.2 (5.4) 75.0 (2.6) 81.9 (3.6) 80.5 (6.7) 0.084
VAS0 4 0 (0.0) 1 (14.3) 1 (12.5) 0 (0.0) 0.062
6 8 (47.1) 2 (28.6) 5 (62.5) 5 (62.5)
8 3 (17.6) 4 (57.1) 0 (0.0) 0 (0.0)
10 6 (35.3) 0 (0.0) 2 (25.0) 3 (37.5)
VAS6W 2 0 (0.0) 1 (14.3) 5 (62.5) 4 (50.0) 0.005
4 11 (64.7) 6 (85.7) 2 (25.0) 2 (25.0)
6 6 (35.3) 0 (0.0) 1 (12.5) 2 (25.0)
VAS12W 1 0 (0.0) 0 (0.0) 1 (12.5) 0 (0.0) 0.272
2 3 (17.6) 1 (14.3) 0 (0.0) 2 (25.0)
3 5 (29.4) 6 (85.7) 5 (62.5) 3 (37.5)
4 5 (29.4) 0 (0.0) 1 (12.5) 1 (12.5)
5 4 (23.5) 0 (0.0) 1 (12.5) 2 (25.0)
VAS6M 2 8 (47.1) 3 (42.9) 6 (75.0) 5 (62.5) 0.508
4 9 (52.9) 4 (57.1) 2 (25.0) 3 (37.5)
FC0 2 7 (41.2) 0 (0.0) 0 (0.0) 0 (0.0) 0.048
3 5 (29.4) 2 (28.6) 4 (50.0) 4 (50.0)
4 5 (29.4) 5 (71.4) 4 (50.0) 4 (50.0)
FC6W 2 4 (23.5) 0 (0.0) 0 (0.0) 0 (0.0) 0.063
3 6 (35.3) 0 (0.0) 0 (0.0) 3 (37.5)
4 2 (11.8) 4 (57.1) 4 (50.0) 3 (37.5)
5 5 (29.4) 3 (42.9) 4 (50.0) 2 (25.0)
FC12W 2 2 (11.8) 0 (0.0) 0 (0.0) 0 (0.0) 0.805
3 2 (11.8) 0 (0.0) 0 (0.0) 1 (12.5)
4 8 (47.1) 5 (71.4) 6 (75.0) 5 (62.5)
5 4 (23.5) 1 (14.3) 2 (25.0) 2 (25.0)
6 1 (5.9) 1 (14.3) 0 (0.0) 0 (0.0)
FC6M 2 4 (23.5) 0 (0.0) 0 (0.0) 0 (0.0) 0.116
4 5 (29.4) 2 (28.6) 4 (50.0) 6 (75.0)
5 8 (47.1) 5 (71.4) 4 (50.0) 2 (25.0)
DURATION_OF_SYMPTOM Mean (SD) 8.0 (2.3) 7.7 (2.0) 7.0 (3.8) 7.5 (2.7) 0.837
tumor EPENDYMOMA 0 (0.0) 0 (0.0) 2 (25.0) 0 (0.0) <0.001
MENINGIOMA 17 (100.0) 0 (0.0) 0 (0.0) 0 (0.0)
NERVE SHEATH TUMOUR 0 (0.0) 7 (100.0) 0 (0.0) 8 (100.0)
OTHER 0 (0.0) 0 (0.0) 6 (75.0) 0 (0.0)
deltavas 2 0 (0.0) 1 (14.3) 1 (12.5) 0 (0.0) 0.381
4 11 (64.7) 6 (85.7) 5 (62.5) 5 (62.5)
6 6 (35.3) 0 (0.0) 2 (25.0) 3 (37.5)
deltaFC 0 4 (23.5) 0 (0.0) 0 (0.0) 2 (25.0) 0.015
1 7 (41.2) 7 (100.0) 8 (100.0) 6 (75.0)
2 6 (35.3) 0 (0.0) 0 (0.0) 0 (0.0)

SUMMARY TABLE BY LOCATION

label levels Cervical Lumbar Thoracic Thoraco Lumbar p
AGE Mean (SD) 41.0 (15.7) 42.5 (18.2) 49.4 (23.1) 44.4 (14.7) 0.661
SEX FEMALE 6 (75.0) 0 (0.0) 16 (88.9) 0 (0.0) <0.001
MALE 2 (25.0) 6 (100.0) 2 (11.1) 8 (100.0)
AXIAL Anterior 0 (0.0) 0 (0.0) 3 (16.7) 3 (37.5) 0.004
Posterolateral 0 (0.0) 0 (0.0) 8 (44.4) 0 (0.0)
Posterior 8 (100.0) 6 (100.0) 7 (38.9) 5 (62.5)
OCCUPANCY Mean (SD) 80.6 (6.0) 80.3 (4.1) 80.9 (5.9) 75.6 (1.8) 0.180
VAS0 4 1 (12.5) 0 (0.0) 1 (5.6) 0 (0.0) 0.327
6 6 (75.0) 3 (50.0) 6 (33.3) 5 (62.5)
8 0 (0.0) 0 (0.0) 5 (27.8) 2 (25.0)
10 1 (12.5) 3 (50.0) 6 (33.3) 1 (12.5)
VAS6W 2 3 (37.5) 2 (33.3) 5 (27.8) 0 (0.0) 0.162
4 5 (62.5) 2 (33.3) 7 (38.9) 7 (87.5)
6 0 (0.0) 2 (33.3) 6 (33.3) 1 (12.5)
VAS12W 1 0 (0.0) 0 (0.0) 1 (5.6) 0 (0.0) 0.216
2 3 (37.5) 0 (0.0) 0 (0.0) 3 (37.5)
3 4 (50.0) 3 (50.0) 8 (44.4) 4 (50.0)
4 1 (12.5) 1 (16.7) 5 (27.8) 0 (0.0)
5 0 (0.0) 2 (33.3) 4 (22.2) 1 (12.5)
VAS6M 2 7 (87.5) 3 (50.0) 7 (38.9) 5 (62.5) 0.136
4 1 (12.5) 3 (50.0) 11 (61.1) 3 (37.5)
FC0 2 0 (0.0) 0 (0.0) 4 (22.2) 3 (37.5) 0.016
3 7 (87.5) 3 (50.0) 3 (16.7) 2 (25.0)
4 1 (12.5) 3 (50.0) 11 (61.1) 3 (37.5)
FC6W 2 0 (0.0) 0 (0.0) 4 (22.2) 0 (0.0) 0.001
3 6 (75.0) 0 (0.0) 0 (0.0) 3 (37.5)
4 1 (12.5) 3 (50.0) 5 (27.8) 4 (50.0)
5 1 (12.5) 3 (50.0) 9 (50.0) 1 (12.5)
FC12W 2 0 (0.0) 0 (0.0) 2 (11.1) 0 (0.0) 0.497
3 1 (12.5) 0 (0.0) 2 (11.1) 0 (0.0)
4 6 (75.0) 3 (50.0) 8 (44.4) 7 (87.5)
5 1 (12.5) 3 (50.0) 4 (22.2) 1 (12.5)
6 0 (0.0) 0 (0.0) 2 (11.1) 0 (0.0)
FC6M 2 0 (0.0) 0 (0.0) 4 (22.2) 0 (0.0) 0.325
4 4 (50.0) 3 (50.0) 5 (27.8) 5 (62.5)
5 4 (50.0) 3 (50.0) 9 (50.0) 3 (37.5)
DURATION_OF_SYMPTOM Mean (SD) 5.9 (1.6) 6.2 (3.8) 9.2 (1.6) 7.1 (2.6) 0.003
tumor EPENDYMOMA 0 (0.0) 1 (16.7) 0 (0.0) 1 (12.5) 0.034
MENINGIOMA 3 (37.5) 0 (0.0) 11 (61.1) 3 (37.5)
NERVE SHEATH TUMOUR 5 (62.5) 2 (33.3) 4 (22.2) 4 (50.0)
OTHER 0 (0.0) 3 (50.0) 3 (16.7) 0 (0.0)
deltavas 2 1 (12.5) 0 (0.0) 1 (5.6) 0 (0.0) 0.522
4 6 (75.0) 3 (50.0) 11 (61.1) 7 (87.5)
6 1 (12.5) 3 (50.0) 6 (33.3) 1 (12.5)
deltaFC 0 0 (0.0) 0 (0.0) 6 (33.3) 0 (0.0) 0.008
1 5 (62.5) 6 (100.0) 12 (66.7) 5 (62.5)
2 3 (37.5) 0 (0.0) 0 (0.0) 3 (37.5)
tumorsa MENINGIOMA 3 (37.5) 0 (0.0) 11 (61.1) 3 (37.5) 0.003
NEUROFIBROMA 1 (12.5) 0 (0.0) 2 (11.1) 4 (50.0)
SCHWANNOMA 4 (50.0) 2 (33.3) 2 (11.1) 0 (0.0)
Other 0 (0.0) 4 (66.7) 3 (16.7) 1 (12.5)

Gender Distribution

The Flipped Bar- plot above shows Counts(X axis) and percentages(annotated within bar) of various categories. 22/40(55 %) patients are in FEMALE , 18/40(45 %) are MALE The Full details of distribution is in table below.

Group n total percentage Confidence_Interval
FEMALE 22 40 55 39.69% - 69.62%
MALE 18 40 45 30.38% - 60.31%

AGE DISTRIBUTION

we found a Significant association between age_grp and tumorsa. The chi-square statistic was 34.56 . The degree of freedom was 18 and P value was 0.01 .Contingency and Proportion table are shown below

MENINGIOMA NEUROFIBROMA SCHWANNOMA Other
0-10 0 0 0 1
20-30 0 2 1 4
30-40 6 0 2 3
40-50 5 2 2 0
50-60 0 1 0 0
60-70 0 2 2 0
70-80 6 0 1 0
tumorsa age_grp n value 95 % Confidence Interval
MENINGIOMA 30-40 6 6/17 ( 35.29 %) 16.29% - 58.86%
MENINGIOMA 40-50 5 5/17 ( 29.41 %) 12.22% - 52.98%
MENINGIOMA 70-80 6 6/17 ( 35.29 %) 16.29% - 58.86%
NEUROFIBROMA 20-30 2 2/7 ( 28.57 %) 6.47% - 64.77%
NEUROFIBROMA 40-50 2 2/7 ( 28.57 %) 6.47% - 64.77%
NEUROFIBROMA 50-60 1 1/7 ( 14.29 %) 1.59% - 50.08%
NEUROFIBROMA 60-70 2 2/7 ( 28.57 %) 6.47% - 64.77%
SCHWANNOMA 20-30 1 1/8 ( 12.5 %) 1.38% - 45.37%
SCHWANNOMA 30-40 2 2/8 ( 25 %) 5.6% - 59.16%
SCHWANNOMA 40-50 2 2/8 ( 25 %) 5.6% - 59.16%
SCHWANNOMA 60-70 2 2/8 ( 25 %) 5.6% - 59.16%
SCHWANNOMA 70-80 1 1/8 ( 12.5 %) 1.38% - 45.37%
Other 0-10 1 1/8 ( 12.5 %) 1.38% - 45.37%
Other 20-30 4 4/8 ( 50 %) 19.9% - 80.1%
Other 30-40 3 3/8 ( 37.5 %) 11.9% - 70.52%

DURATION OF SYMPTOMS

SITE <6 >6
Cervical 4 4
Lumbar 4 2
Thoracic 1 17
Thoraco Lumbar 3 5

PRE-OP FRENKEL SCORES

SITE 2 3 4
Cervical 7 1
Lumbar 3 3
Thoracic 4 3 11
Thoraco Lumbar 3 2 3
DIAGNOSIS 2 3 4
DERMOID CYST 1
EPENDYMOMA 1 1
EPIDERMOID CYST 1
MENINGIOMA 7 5 5
NEUROENTERIC CYST 2
NEUROFIBROMA 2 5
PARAGANGLIOMA 2
SCHWANNOMA 4 4

PREOP_PAIN - VISUAL ANALOG SCALE

DIAGNOSIS 4 6 8 10
DERMOID CYST 1
EPENDYMOMA 1 1
EPIDERMOID CYST 1
MENINGIOMA 8 3 6
NEUROENTERIC CYST 2
NEUROFIBROMA 1 2 4
PARAGANGLIOMA 2
SCHWANNOMA 5 3
SITE 4 6 8 10
Cervical 1 6 1
Lumbar 3 3
Thoracic 1 6 5 6
Thoraco Lumbar 5 2 1

DISTRIBUTION OF TUMOUR SITE

DIAGNOSIS Cervical Lumbar Thoracic Thoraco Lumbar
DERMOID CYST 1
EPENDYMOMA 1 1
EPIDERMOID CYST 1
MENINGIOMA 3 11 3
NEUROENTERIC CYST 2
NEUROFIBROMA 1 2 4
PARAGANGLIOMA 2
SCHWANNOMA 4 2 2
DIAGNOSIS Anterior Posterolateral Posterior
DERMOID CYST 1
EPENDYMOMA 2
EPIDERMOID CYST 1
MENINGIOMA 4 4 9
NEUROENTERIC CYST 2
NEUROFIBROMA 2 5
PARAGANGLIOMA 2
SCHWANNOMA 2 6

GENDER DISTRIBUTION BY DIAGNOSIS

DIAGNOSIS FEMALE MALE
DERMOID CYST 1
EPENDYMOMA 2
EPIDERMOID CYST 1
MENINGIOMA 14 3
NEUROENTERIC CYST 2
NEUROFIBROMA 7
PARAGANGLIOMA 2
SCHWANNOMA 5 3

POST OP FRENKEL GRADE DISTRIBUTION

value FC0 FC6W FC12W FC6M
2 7 4 2 4
3 15 9 3
4 18 13 24 17
5 14 11 19

POST OP PAIN SCALE DISTRIBUTION

value VAS0 VAS6W VAS12W VAS6M
1 1
2 10 6 22
3 19
4 2 21 7 18
5 7
6 20 9
8 7
10 11

CORRELATION BETWEEN DURATION OF SYMPTOMS AND IMPROVEMENT IN FRENKEL GRADE

The scatter plot above shows relationship between DURATION_OF_SYMPTOM on X axis and improvement in Frenkel Grade(FC6M - FC0) on Y axis. Graphically, we see that as DURATION_OF_SYMPTOM increases, improvement in Frenkel Grade decreases . On a formal statistical linear regression analysis, we that line of best fit (blue line signifying line with least square difference) also has a negative slope implying a negative correlation. The gray shaded error around blue line signifies 95% confidence interval of linear regression line of best fit. The correlation between two variables is Significant . The Pearson’s correlation between DURATION_OF_SYMPTOM and improvement in Frenkel Grade is -0.45 with 95% Confidence Interval of -0.67 to -0.16. the t statistic is -3.08 The p value is <0.001 .The degree of freedom is 38. In formal statistical notation this expressed as t(38)= -3.08, P= <0.001. r(Pearson) = -0.45 95% C.I. [-0.67–0.16]. n= 40. The correlation is summmarised in table below

Group 1 Group 2 Degree of Freedom T statistic Correlation 95 % C.I. P value
DURATION_OF_SYMPTOM deltaFC 38 -3.08 -0.45 -0.67–0.16 <0.001
variable n Mean SD Median Minimum Maximum
deltaFC 40 1.00 0.555 1 0 2
DURATION_OF_SYMPTOM 40 7.65 2.587 8 3 12

CORRELATION BETWEEN TUMOR OCCUPANCY AND IMPROVEMENT IN FRENKEL GRADE

The scatter plots above show relationship between OCCUPANCY on X axis and deltaFC on Y axis. Graphically, we see that as OCCUPANCY increases, deltaFC decreases .
On a formal statistical linear regression analysis, we that line of best fit (blue line signifying line with least square difference) also has a negative slope implying a negative correlation.
The gray shaded error around blue line signifies 95% confidence interval of linear regression line of best fit.
The correlation between two variables is Significant . The Pearson's correlation between OCCUPANCY and deltaFC is -0.34 with 95% Confidence Interval of -0.59 to -0.03. the t statistic is -2.2 The p value is 0.03 .The degree of freedom is 38.
In formal statistical notation this expressed as t(38)= -2.2, P= 0.03. r(Pearson) = -0.34 95% C.I. [-0.59--0.03]. n= 40. The correlation is summmarised in table below
Group 1 Group 2 Degree of Freedom T statistic Correlation 95 % C.I. P value
OCCUPANCY deltaFC 38 -2.2 -0.34 -0.59–0.03 0.03
variable n Mean SD Median Minimum Maximum
deltaFC 40 1.0 0.555 1.0 0 2
OCCUPANCY 40 79.7 5.365 78.5 71 88

Variation Of VAS with time

This is a trace-plot of variation in Pain Scale (on Y axis) with passage of of time on X-axis , Pain Ratings across various stages are connected by distinct colored trace-line . Individual readings have been plotted on graph and points have been jittered for better clarity . The raw data points representing two groups have different shapes as indicated in the legend. The points across the trace represent the mean readings in two groups and whiskers represent Standard error of measurements.

we can clearly see a negative trend/slope indicating a fall in Pain with passage of Time.we decided to explore this intuitive graphical relationship with formal statistical tests.

Effect df MSE F ges p.value
key 2.66, 103.57 0.60 310.31 *** .63 <.0001
contrast estimate SE df t.ratio p.value
VAS0 - VAS6W 3.400 0.1626191 117 20.907750 0.0000000
VAS0 - VAS12W 4.025 0.1626191 117 24.751087 0.0000000
VAS0 - VAS6M 4.450 0.1626191 117 27.364556 0.0000000
VAS6W - VAS12W 0.625 0.1626191 117 3.843336 0.0011212
VAS6W - VAS6M 1.050 0.1626191 117 6.456805 0.0000000
VAS12W - VAS6M 0.425 0.1626191 117 2.613469 0.0491028

Change in Frenkel Grade with Time

This is a trace-plot of variation in Frenkel Grade (on Y axis) with passage of of time on X-axis , Frenkel Grade across various stages are connected by distinct colored trace-line . Individual readings have been plotted on graph and points have been jittered for better clarity . The raw data points representing two groups have different shapes as indicated in the legend. The points across the trace represent the mean readings in two groups and whiskers represent Standard error of measurements.

we can clearly see a negative trend/slope indicating a rise / improvement in Frenkel with passage of Time.we decided to explore this intuitive graphical relationship with formal statistical tests.

Effect df MSE F ges p.value
key 2.74, 106.84 0.16 51.31 *** .17 <.0001
contrast estimate SE df t.ratio p.value
FC0 - FC6W -0.650 0.0861852 117 -7.541900 0.0000000
FC0 - FC12W -0.825 0.0861852 117 -9.572412 0.0000000
FC0 - FC6M -1.000 0.0861852 117 -11.602923 0.0000000
FC6W - FC12W -0.175 0.0861852 117 -2.030512 0.1827742
FC6W - FC6M -0.350 0.0861852 117 -4.061023 0.0005090
FC12W - FC6M -0.175 0.0861852 117 -2.030512 0.1827742