Inference for numerical data

North Carolina births

In 2004, the state of North Carolina released a large data set containing information on births recorded in this state. This data set is useful to researchers studying the relation between habits and practices of expectant mothers and the birth of their children. We will work with a random sample of observations from this data set.

Exploratory analysis

Load the nc data set into our workspace.

load("more/nc.RData")
head(nc)

##   fage mage      mature weeks    premie visits marital gained weight
## 1   NA   13 younger mom    39 full term     10 married     38   7.63
## 2   NA   14 younger mom    42 full term     15 married     20   7.88
## 3   19   15 younger mom    37 full term     11 married     38   6.63
## 4   21   15 younger mom    41 full term      6 married     34   8.00
## 5   NA   15 younger mom    39 full term      9 married     27   6.38
## 6   NA   15 younger mom    38 full term     19 married     22   5.38
##   lowbirthweight gender     habit  whitemom
## 1        not low   male nonsmoker not white
## 2        not low   male nonsmoker not white
## 3        not low female nonsmoker     white
## 4        not low   male nonsmoker     white
## 5        not low female nonsmoker not white
## 6            low   male nonsmoker not white

We have observations on 13 different variables, some categorical and some numerical. The meaning of each variable is as follows.

variable	description
`fage`	father’s age in years.
`mage`	mother’s age in years.
`mature`	maturity status of mother.
`weeks`	length of pregnancy in weeks.
`premie`	whether the birth was classified as premature (premie) or full-term.
`visits`	number of hospital visits during pregnancy.
`marital`	whether mother is `married` or `not married` at birth.
`gained`	weight gained by mother during pregnancy in pounds.
`weight`	weight of the baby at birth in pounds.
`lowbirthweight`	whether baby was classified as low birthweight (`low`) or not (`not low`).
`gender`	gender of the baby, `female` or `male`.
`habit`	status of the mother as a `nonsmoker` or a `smoker`.
`whitemom`	whether mom is `white` or `not white`.

What are the cases in this data set? How many cases are there in our sample?

str(nc)

## 'data.frame':    1000 obs. of  13 variables:
##  $ fage          : int  NA NA 19 21 NA NA 18 17 NA 20 ...
##  $ mage          : int  13 14 15 15 15 15 15 15 16 16 ...
##  $ mature        : Factor w/ 2 levels "mature mom","younger mom": 2 2 2 2 2 2 2 2 2 2 ...
##  $ weeks         : int  39 42 37 41 39 38 37 35 38 37 ...
##  $ premie        : Factor w/ 2 levels "full term","premie": 1 1 1 1 1 1 1 2 1 1 ...
##  $ visits        : int  10 15 11 6 9 19 12 5 9 13 ...
##  $ marital       : Factor w/ 2 levels "married","not married": 1 1 1 1 1 1 1 1 1 1 ...
##  $ gained        : int  38 20 38 34 27 22 76 15 NA 52 ...
##  $ weight        : num  7.63 7.88 6.63 8 6.38 5.38 8.44 4.69 8.81 6.94 ...
##  $ lowbirthweight: Factor w/ 2 levels "low","not low": 2 2 2 2 2 1 2 1 2 2 ...
##  $ gender        : Factor w/ 2 levels "female","male": 2 2 1 2 1 2 2 2 2 1 ...
##  $ habit         : Factor w/ 2 levels "nonsmoker","smoker": 1 1 1 1 1 1 1 1 1 1 ...
##  $ whitemom      : Factor w/ 2 levels "not white","white": 1 1 2 2 1 1 1 1 2 2 ...

There are total of 1000 cases in this data set. The cases are child births in the state of North Carolina in 2004.

As a first step in the analysis, we should consider summaries of the data. This can be done using the summary command:

summary(nc)

##       fage            mage            mature        weeks      
##  Min.   :14.00   Min.   :13   mature mom :133   Min.   :20.00  
##  1st Qu.:25.00   1st Qu.:22   younger mom:867   1st Qu.:37.00  
##  Median :30.00   Median :27                     Median :39.00  
##  Mean   :30.26   Mean   :27                     Mean   :38.33  
##  3rd Qu.:35.00   3rd Qu.:32                     3rd Qu.:40.00  
##  Max.   :55.00   Max.   :50                     Max.   :45.00  
##  NA's   :171                                    NA's   :2      
##        premie        visits            marital        gained     
##  full term:846   Min.   : 0.0   married    :386   Min.   : 0.00  
##  premie   :152   1st Qu.:10.0   not married:613   1st Qu.:20.00  
##  NA's     :  2   Median :12.0   NA's       :  1   Median :30.00  
##                  Mean   :12.1                     Mean   :30.33  
##                  3rd Qu.:15.0                     3rd Qu.:38.00  
##                  Max.   :30.0                     Max.   :85.00  
##                  NA's   :9                        NA's   :27     
##      weight       lowbirthweight    gender          habit    
##  Min.   : 1.000   low    :111    female:503   nonsmoker:873  
##  1st Qu.: 6.380   not low:889    male  :497   smoker   :126  
##  Median : 7.310                               NA's     :  1  
##  Mean   : 7.101                                              
##  3rd Qu.: 8.060                                              
##  Max.   :11.750                                              
##                                                              
##       whitemom  
##  not white:284  
##  white    :714  
##  NA's     :  2  
##                 
##                 
##                 
##

As you review the variable summaries, consider which variables are categorical and which are numerical. For numerical variables, are there outliers? If you aren’t sure or want to take a closer look at the data, make a graph.

Consider the possible relationship between a mother’s smoking habit and the weight of her baby. Plotting the data is a useful first step because it helps us quickly visualize trends, identify strong associations, and develop research questions.

Make a side-by-side boxplot of habit and weight. What does the plot highlight about the relationship between these two variables?

boxplot(nc$weight~nc$habit)

The median of nonsmoker is slighltly higher than smoker but they are close. There are more outliers in the nonsmoker mothers than smoker mothers. The lower whisker is around the same (4) for both smoker and nonsmoker mothers.

The box plots show how the medians of the two distributions compare, but we can also compare the means of the distributions using the following function to split the weight variable into the habit groups, then take the mean of each using the mean function.

by(nc$weight, nc$habit, mean)

## nc$habit: nonsmoker
## [1] 7.144273
## -------------------------------------------------------- 
## nc$habit: smoker
## [1] 6.82873

There is an observed difference, but is this difference statistically significant? In order to answer this question we will conduct a hypothesis test .

Inference

Check if the conditions necessary for inference are satisfied. Note that you will need to obtain sample sizes to check the conditions. You can compute the group size using the same by command above but replacing mean with length.

by(nc$weight, nc$habit, length)

## nc$habit: nonsmoker
## [1] 873
## -------------------------------------------------------- 
## nc$habit: smoker
## [1] 126

Assuming the sample set is random, it is less than 10% of the population.We can look at the distribution to see the if it is normal distribution and if there is skeweness.

library(ggplot2)
ggplot(nc, aes(x=weight))+
  geom_histogram(aes(fill=habit))

## `stat_bin()` using `bins = 30`. Pick better value with `binwidth`.

We can see the distribution is close to normal and there isnt extreme skeweness.

Write the hypotheses for testing if the average weights of babies born to smoking and non-smoking mothers are different.

Null hypothesis is average weights of babies born to smoking and non-smoking mothers are the same.

$H_{o}:\mu_{non-smoking}=\mu_{smoking}$

Alternative hypothesis is average weights of babies born to smoking and non-smoking mothers are not the same.

$H_{A}:\mu_{non_smoking}\neq\mu_{smoking}$

Next, we introduce a new function, inference, that we will use for conducting hypothesis tests and constructing confidence intervals.

inference(y = nc$weight, x = nc$habit, est = "mean", type = "ht", null = 0, 
          alternative = "twosided", method = "theoretical")

## Response variable: numerical, Explanatory variable: categorical
## Difference between two means
## Summary statistics:
## n_nonsmoker = 873, mean_nonsmoker = 7.1443, sd_nonsmoker = 1.5187
## n_smoker = 126, mean_smoker = 6.8287, sd_smoker = 1.3862

## Observed difference between means (nonsmoker-smoker) = 0.3155
## 
## H0: mu_nonsmoker - mu_smoker = 0 
## HA: mu_nonsmoker - mu_smoker != 0 
## Standard error = 0.134 
## Test statistic: Z =  2.359 
## p-value =  0.0184

Let’s pause for a moment to go through the arguments of this custom function. The first argument is y, which is the response variable that we are interested in: nc$weight. The second argument is the explanatory variable, x, which is the variable that splits the data into two groups, smokers and non-smokers: nc$habit. The third argument, est, is the parameter we’re interested in: "mean" (other options are "median", or "proportion".) Next we decide on the type of inference we want: a hypothesis test ("ht") or a confidence interval ("ci"). When performing a hypothesis test, we also need to supply the null value, which in this case is 0, since the null hypothesis sets the two population means equal to each other. The alternative hypothesis can be "less", "greater", or "twosided". Lastly, the method of inference can be "theoretical" or "simulation" based.

Change the type argument to "ci" to construct and record a confidence interval for the difference between the weights of babies born to smoking and non-smoking mothers.

inference(y = nc$weight, x = nc$habit, est = "mean", type = "ci", null = 0, 
          alternative = "twosided", method = "theoretical")

## Response variable: numerical, Explanatory variable: categorical
## Difference between two means
## Summary statistics:
## n_nonsmoker = 873, mean_nonsmoker = 7.1443, sd_nonsmoker = 1.5187
## n_smoker = 126, mean_smoker = 6.8287, sd_smoker = 1.3862

## Observed difference between means (nonsmoker-smoker) = 0.3155
## 
## Standard error = 0.1338 
## 95 % Confidence interval = ( 0.0534 , 0.5777 )

The confindence interval is 95% confidence interval (0.0534, 0.5777)

By default the function reports an interval for ($\mu_{nonsmoker} - \mu_{smoker}$) . We can easily change this order by using the order argument:

inference(y = nc$weight, x = nc$habit, est = "mean", type = "ci", null = 0, 
          alternative = "twosided", method = "theoretical", 
          order = c("smoker","nonsmoker"))

## Response variable: numerical, Explanatory variable: categorical
## Difference between two means
## Summary statistics:
## n_smoker = 126, mean_smoker = 6.8287, sd_smoker = 1.3862
## n_nonsmoker = 873, mean_nonsmoker = 7.1443, sd_nonsmoker = 1.5187

## Observed difference between means (smoker-nonsmoker) = -0.3155
## 
## Standard error = 0.1338 
## 95 % Confidence interval = ( -0.5777 , -0.0534 )

On your own

Calculate a 95% confidence interval for the average length of pregnancies (weeks) and interpret it in context. Note that since you’re doing inference on a single population parameter, there is no explanatory variable, so you can omit the x variable from the function.

inference(y = nc$weeks, est = "mean", type = "ci", null = 0, 
          alternative = "twosided", method = "theoretical", 
          order = c("smoker","nonsmoker"))

## Single mean 
## Summary statistics:

## mean = 38.3347 ;  sd = 2.9316 ;  n = 998 
## Standard error = 0.0928 
## 95 % Confidence interval = ( 38.1528 , 38.5165 )

Calculate a new confidence interval for the same parameter at the 90% confidence level. You can change the confidence level by adding a new argument to the function: conflevel = 0.90.

inference(y = nc$weeks, est = "mean", type = "ci", null = 0, 
          alternative = "twosided", method = "theoretical", 
          order = c("smoker","nonsmoker"), conflevel = 0.90)

## Single mean 
## Summary statistics:

## mean = 38.3347 ;  sd = 2.9316 ;  n = 998 
## Standard error = 0.0928 
## 90 % Confidence interval = ( 38.182 , 38.4873 )

Conduct a hypothesis test evaluating whether the average weight gained by younger mothers is different than the average weight gained by mature mothers.

Null hypothesis: Average weight gained by younger mothers is same as the average weight gained by mature mothers.

$H_{o}: \mu_{younger}=\mu_{mature}$

Alternarive hypothesis: Average weight gained by younger mothers is not the same as the average weight gained by mature mothers.

$H_{A}: \mu_{younger}\neq \mu_{mature}$

inference(y = nc$gained, x = nc$mature, est = "mean", type = "ci", null = 0, 
          alternative = "twosided", method = "theoretical")

## Response variable: numerical, Explanatory variable: categorical
## Difference between two means
## Summary statistics:
## n_mature mom = 129, mean_mature mom = 28.7907, sd_mature mom = 13.4824
## n_younger mom = 844, mean_younger mom = 30.5604, sd_younger mom = 14.3469

## Observed difference between means (mature mom-younger mom) = -1.7697
## 
## Standard error = 1.2857 
## 95 % Confidence interval = ( -4.2896 , 0.7502 )

Now, a non-inference task: Determine the age cutoff for younger and mature mothers. Use a method of your choice, and explain how your method works.

by(nc$mage, nc$mature, range)

## nc$mature: mature mom
## [1] 35 50
## -------------------------------------------------------- 
## nc$mature: younger mom
## [1] 13 34

The method gives us the range of mature and younger mothers. The age cutoff for younger and mature mother is 35.

Pick a pair of numerical and categorical variables and come up with a research question evaluating the relationship between these variables. Formulate the question in a way that it can be answered using a hypothesis test and/or a confidence interval. Answer your question using the inference function, report the statistical results, and also provide an explanation in plain language.

Research Question: Are there any correlation between premature births and mother’s age?

Null Hypothesis: Average age of mothers is same for premeture and full term babies.

$H_{o}: \mu_{premeture}=\mu_{full_term}$

Alternative Hypothesis: Average age of mothers is not same for permeture and full term babies.

$H_{A}: \mu_{premeture}\neq \mu_{full_term}$

inference(y = nc$mage, x=nc$premie,  est = "mean", type = "ht", null = 0, 
          alternative = "twosided", method = "theoretical", conflevel = 0.95)

## Response variable: numerical, Explanatory variable: categorical
## Difference between two means
## Summary statistics:
## n_full term = 846, mean_full term = 27, sd_full term = 6.1444
## n_premie = 152, mean_premie = 26.875, sd_premie = 6.533

## Observed difference between means (full term-premie) = 0.125
## 
## H0: mu_full term - mu_premie = 0 
## HA: mu_full term - mu_premie != 0 
## Standard error = 0.57 
## Test statistic: Z =  0.219 
## p-value =  0.8266

p > 0.05 , so we do not reject the null hypothesis. Average age of mothers is the same for premature and full term babies.