data pulled: 2019-08-26
written: 2019-08-26
last ran: 2019-08-26
website: http://rpubs.com/navona/RISH_matching_CMH-MRC

General description

This code is used to identify matched controls, as required to test an implementation of the RISH harmonization method described in Karayumak et al., 2019. We use data from the SPINS study, and match 5 target sites (CMP, MRC, MRP, ZHH, ZHP) to the reference site (CMH).

In all cases, we aim to identify the gold-standard of n=20 matched ‘healthy control’ participants (or at least, the recommended n=16-18), on the basis of sex, age,IQ (here, established by WTAR), and handedness.

Data count

	reference	targets
	CMH	CMP	MRC	MRP	ZHH	ZHP
female	20	7	9	15	10	19
male	27	3	16	17	7	21

Before matching

	CMH	MRC	p
n	47	25
age (mean (SD))	27.04 (8.30)	37.04 (11.14)	<0.001
sex = male (%)	27 (57.4)	16 (64.0)	0.774
wtar_std (mean (SD))	115.81 (9.07)	116.28 (9.65)	0.838

males
	CMH	MRC	p
n	27	16
age (mean (SD))	27.19 (8.70)	35.56 (9.80)	0.006
wtar_std (mean (SD))	115.81 (9.02)	118.12 (6.58)	0.378

females
	CMH	MRC	p
n	20	9
age (mean (SD))	26.85 (7.96)	39.67 (13.41)	0.003
wtar_std (mean (SD))	115.80 (9.37)	113.00 (13.40)	0.521

After matching

	CMH	MRC	p
n	20	20
age (mean (SD))	31.00 (10.28)	37.00 (11.97)	0.097
sex = male (%)	11 (55.0)	11 (55.0)	1.000
wtar_std (mean (SD))	116.15 (10.65)	115.15 (10.00)	0.761
distance (mean (SD))	0.37 (0.23)	0.49 (0.25)	0.120

List of matched pairs

males

SPN01_CMH_0135	SPN01_MRC_0036
SPN01_CMH_0008	SPN01_MRC_0058
SPN01_CMH_0171	SPN01_MRC_0071
SPN01_CMH_0015	SPN01_MRC_0028
SPN01_CMH_0091	SPN01_MRC_0043
SPN01_CMH_0038	SPN01_MRC_0033
SPN01_CMH_0123	SPN01_MRC_0016
SPN01_CMH_0040	SPN01_MRC_0037
SPN01_CMH_0149	SPN01_MRC_0029
SPN01_CMH_0158	SPN01_MRC_0026
SPN01_CMH_0119	SPN01_MRC_0027

females

SPN01_CMH_0017	SPN01_MRC_0070
SPN01_CMH_0054	SPN01_MRC_0020
SPN01_CMH_0026	SPN01_MRC_0068
SPN01_CMH_0134	SPN01_MRC_0057
SPN01_CMH_0159	SPN01_MRC_0065
SPN01_CMH_0020	SPN01_MRC_0066
SPN01_CMH_0194	SPN01_MRC_0021
SPN01_CMH_0014	SPN01_MRC_0024
SPN01_CMH_0125	SPN01_MRC_0064

Special notes

We could not match on the basis of handedness (established by EHI ≥ .5), due to sample characteristics.

Because only 9 female HC subjects we available, we matched on the basis of 9 female and 11 male subjects.

SPINS participant matching CMH & MRC