RESULTS
Summary Demographic Table
Table 1 . summary Distribution of all variables ,Groupwise
| Dependent: MUSCLE_PRESENT_IN_HPE_OF_RE_TURBT | MUSCLE FREE | MUSCLE INVOLVED | p | |
|---|---|---|---|---|
| AGE | Mean (SD) | 56.2 (13.1) | 53.0 (18.3) | 0.373 |
| SEX | F | 38 (16.0) | 0 (0.0) | 0.117 |
| M | 199 (84.0) | 13 (100.0) | ||
| SMOKING_TOBACCO_CHEWING_HISTORY | No | 103 (43.5) | 4 (30.8) | 0.368 |
| Yes | 134 (56.5) | 9 (69.2) | ||
| IMAGING_FINDING_OF_UB_MASS | Multiple Growth | 36 (15.2) | 1 (7.7) | 0.459 |
| Single Growth | 201 (84.8) | 12 (92.3) | ||
| UPPER_TRACT_ON_IMAGING | HDUN | 7 (3.0) | 4 (30.8) | <0.001 |
| NORMAL | 230 (97.0) | 9 (69.2) | ||
| PERIVESICAL_FAT_STRANDING_ON_IMAGING | Absent | 203 (85.7) | 3 (23.1) | <0.001 |
| Present | 34 (14.3) | 10 (76.9) | ||
| LYPHM_NODE_STATUS_ON_IMAGING | Negative | 237 (100.0) | 13 (100.0) | NA |
| SIZE_OF_GROWTH_DURING_PRIMARY_TURBT | < 3 CM | 84 (35.4) | 1 (7.7) | 0.040 |
| >3 CM | 153 (64.6) | 12 (92.3) | ||
| NO_OF_GROWTH_DURING_PRIMARY_TURBT | Multiple | 56 (23.6) | 2 (15.4) | 0.493 |
| Single | 181 (76.4) | 11 (84.6) | ||
| TYPE_OF_GROWTH | Carpet | 6 (2.5) | 0 (0.0) | 0.817 |
| Papillary | 189 (79.7) | 11 (84.6) | ||
| Solid | 42 (17.7) | 2 (15.4) | ||
| BTA_TEST | NEGATIVE | 83 (35.0) | 2 (15.4) | 0.146 |
| POSITIVE | 154 (65.0) | 11 (84.6) | ||
| URINE_FOR_MALIGNANTCYTOLOGY | NEGATIVE | 153 (64.6) | 7 (53.8) | 0.433 |
| POSITIVE | 84 (35.4) | 6 (46.2) | ||
| TIME_REQUIRED_FOR_PRIMARY_TURBT | < 30 MIN | 94 (39.7) | 1 (7.7) | 0.021 |
| >30 MIN | 143 (60.3) | 12 (92.3) | ||
| POST_OP_INTRAVESICAL_MMC_GIVEN | Given | 237 (100.0) | 13 (100.0) | NA |
| HPE_OF_PRIMARY_TURBT | CIS | 2 (0.8) | 0 (0.0) | 0.443 |
| T1G1 | 116 (48.9) | 4 (30.8) | ||
| T1G3 | 111 (46.8) | 9 (69.2) | ||
| TaG3 | 8 (3.4) | 0 (0.0) | ||
| MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN | Absent | 36 (15.2) | 7 (53.8) | <0.001 |
| Present | 201 (84.8) | 6 (46.2) | ||
| TIMING_OF_RE_TURBT_AFTER_PRIMARY_TURBT_WEEKS | Mean (SD) | 3.9 (0.7) | 4.2 (0.7) | 0.173 |
| CYSTOSCOPIC_FINDING_OF_RE_TURBT | No growth | 200 (84.4) | 4 (30.8) | <0.001 |
| Recurrent growth present | 37 (15.6) | 9 (69.2) | ||
| HPE_OF_RE_TURBT | No tumour | 179 (75.5) | 0 (0.0) | <0.001 |
| T1G1 | 5 (2.1) | 0 (0.0) | ||
| T1G3 | 53 (22.4) | 0 (0.0) | ||
| T2G3 | 0 (0.0) | 13 (100.0) | ||
| CHECK_CPE_3MONTHS | N | 195 (82.3) | NA | NA |
| Recurrent growth present | 42 (17.7) | NA |
Demographic Variables
Distribution of Demographic Variables in Our Population
Age
Fig.1 Plot of Age distribution across Groups
The Dodged bar chart above represents individual counts representing frequency of age_grp categories 40-50,60-70,50-60,70-80,80-90,30-40 and 20-30 in categories MUSCLE FREE and MUSCLE INVOLVED . Subgroup 50-60 has highest percentage 73/237 ( 30.8 % ) in group MUSCLE FREE . Subgroup 50-60 has highest percentage 4/13 ( 30.77 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Non-significant association between age_grp and MUSCLE INVOLVEMENT on restage TURBT. The chi-square statistic was 7.17 . The degree of freedom was 6 and P value was 0.31 .Contingency and Proportion table are shown below
Table 2
| MUSCLE_INVOLVEMENT | age_grp | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | 20-30 | 12 | 12/237 ( 5.06 %) | 2.8% - 8.42% |
| MUSCLE FREE | 30-40 | 20 | 20/237 ( 8.44 %) | 5.4% - 12.48% |
| MUSCLE FREE | 40-50 | 39 | 39/237 ( 16.46 %) | 12.16% - 21.57% |
| MUSCLE FREE | 50-60 | 73 | 73/237 ( 30.8 %) | 25.18% - 36.89% |
| MUSCLE FREE | 60-70 | 66 | 66/237 ( 27.85 %) | 22.44% - 33.8% |
| MUSCLE FREE | 70-80 | 23 | 23/237 ( 9.7 %) | 6.42% - 13.96% |
| MUSCLE FREE | 80-90 | 4 | 4/237 ( 1.69 %) | 0.57% - 3.96% |
| MUSCLE INVOLVED | 20-30 | 2 | 2/13 ( 15.38 %) | 3.34% - 40.9% |
| MUSCLE INVOLVED | 30-40 | 2 | 2/13 ( 15.38 %) | 3.34% - 40.9% |
| MUSCLE INVOLVED | 40-50 | 2 | 2/13 ( 15.38 %) | 3.34% - 40.9% |
| MUSCLE INVOLVED | 50-60 | 4 | 4/13 ( 30.77 %) | 11.39% - 57.7% |
| MUSCLE INVOLVED | 60-70 | 1 | 1/13 ( 7.69 %) | 0.84% - 30.71% |
| MUSCLE INVOLVED | 70-80 | 1 | 1/13 ( 7.69 %) | 0.84% - 30.71% |
| MUSCLE INVOLVED | 80-90 | 1 | 1/13 ( 7.69 %) | 0.84% - 30.71% |
Table 3
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| 20-30 | 12 | 2 |
| 30-40 | 20 | 2 |
| 40-50 | 39 | 2 |
| 50-60 | 73 | 4 |
| 60-70 | 66 | 1 |
| 70-80 | 23 | 1 |
| 80-90 | 4 | 1 |
Gender
Figure 2 Sex Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of Males and Females in categories MUSCLE FREE and MUSCLE INVOLVED . Males have highest percentage 199/237 ( 83.97 % ) in group MUSCLE FREE . Males also have highest percentage 13/13 ( 100 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Non-significant association between SEX and MUSCLE INVOLVEMENT. The chi-square statistic was 1.37 . The degree of freedom was 1 and P value was 0.117 .Contingency and Proportion table are shown below
Table 5
| MUSCLE_INVOLVEMENT | SEX | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | F | 38 | 38/237 ( 16.03 %) | 11.79% - 21.1% |
| MUSCLE FREE | M | 199 | 199/237 ( 83.97 %) | 78.9% - 88.21% |
| MUSCLE INVOLVED | M | 13 | 13/13 ( 100 %) | 82.74% - 100% |
Table 6
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| F | 38 | 0 |
| M | 199 | 13 |
UPPER TRACT IMAGING
Figure 3 UPPER_TRACT_ON_IMAGING Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of UPPER_TRACT_ON_IMAGING categories NORMAL and HDUN in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE INVOLVEMENT. Subgroup NORMAL has highest percentage 230/237 ( 97.05 % ) in group MUSCLE FREE . Subgroup NORMAL has highest percentage 9/13 ( 69.23 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Significant association between UPPER_TRACT_ON_IMAGING and MUSCLE_INVOLVEMENT. The chi-square statistic was 16.54 . The degree of freedom was 1 and P value was <0.001 .Contingency and Proportion table are shown below.
Table 7
| MUSCLE_INVOLVEMENT | UPPER_TRACT_ON_IMAGING | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | HDUN | 7 | 7/237 ( 2.95 %) | 1.33% - 5.71% |
| MUSCLE FREE | NORMAL | 230 | 230/237 ( 97.05 %) | 94.29% - 98.67% |
| MUSCLE INVOLVED | HDUN | 4 | 4/13 ( 30.77 %) | 11.39% - 57.7% |
| MUSCLE INVOLVED | NORMAL | 9 | 9/13 ( 69.23 %) | 42.3% - 88.61% |
Table 8
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| HDUN | 7 | 4 |
| NORMAL | 230 | 9 |
SIZE OF GROWTH
Figure 4 SIZE OF TUMOUR GROWTH_DURING_PRIMARY_TURBT Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of TUMOUR_SIZE categories >3 CM and < 3 CM in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup >3 CM has highest percentage 153/237 ( 64.56 % ) in group MUSCLE FREE . Subgroup >3 CM has highest percentage 12/13 ( 92.31 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a significant association between TUMOUR_SIZE and MUSCLE_INVOLVEMENT. The chi-square statistic was 4.01 . The degree of freedom was 1 and P value was 0.04 .Contingency and Proportion table are shown below
Table 9
| MUSCLE_INVOLVEMENT | TUMOUR_SIZE | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | < 3 CM | 84 | 84/237 ( 35.44 %) | 29.56% - 41.68% |
| MUSCLE FREE | >3 CM | 153 | 153/237 ( 64.56 %) | 58.32% - 70.44% |
| MUSCLE INVOLVED | < 3 CM | 1 | 1/13 ( 7.69 %) | 0.84% - 30.71% |
| MUSCLE INVOLVED | >3 CM | 12 | 12/13 ( 92.31 %) | 69.29% - 99.16% |
Table 10
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| < 3 CM | 84 | 1 |
| >3 CM | 153 | 12 |
BLADDER TUMOUR ANTIGEN TEST
Figure 5 BTA_TEST Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of BTA_TEST categories NEGATIVE and POSITIVE in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup POSITIVE has highest percentage 154/237 ( 64.98 % ) in group MUSCLE FREE . Subgroup POSITIVE has highest percentage 11/13 ( 84.62 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Non-significant association between BTA_TEST and MUSCLE_INVOLVEMENT. The chi-square statistic was 1.33 . The degree of freedom was 1 and P value was 0.146 .Contingency and Proportion table are shown below
Table 11
| MUSCLE_INVOLVEMENT | BTA_TEST | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | NEGATIVE | 83 | 83/237 ( 35.02 %) | 29.16% - 41.25% |
| MUSCLE FREE | POSITIVE | 154 | 154/237 ( 64.98 %) | 58.75% - 70.84% |
| MUSCLE INVOLVED | NEGATIVE | 2 | 2/13 ( 15.38 %) | 3.34% - 40.9% |
| MUSCLE INVOLVED | POSITIVE | 11 | 11/13 ( 84.62 %) | 59.1% - 96.66% |
Table 12
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| NEGATIVE | 83 | 2 |
| POSITIVE | 154 | 11 |
URINE FOR MALIGNANT CYTOLOGY
Figure 6 URINE_FOR_MALIGNANTCYTOLOGY Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of URINE_FOR_MALIGNANTCYTOLOGY categories NEGATIVE and POSITIVE in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup NEGATIVE has highest percentage 153/237 ( 64.56 % ) in group MUSCLE FREE . Subgroup NEGATIVE has highest percentage 7/13 ( 53.85 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Non-significant association between URINE_FOR_MALIGNANTCYTOLOGY and MUSCLE_INVOLVEMENT. The chi-square statistic was 0.24 . The degree of freedom was 1 and P value was 0.63 .Contingency and Proportion table are shown below
Table 13
| MUSCLE_INVOLVEMENT | URINE_FOR_MALIGNANTCYTOLOGY | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | NEGATIVE | 153 | 153/237 ( 64.56 %) | 58.32% - 70.44% |
| MUSCLE FREE | POSITIVE | 84 | 84/237 ( 35.44 %) | 29.56% - 41.68% |
| MUSCLE INVOLVED | NEGATIVE | 7 | 7/13 ( 53.85 %) | 28.29% - 77.89% |
| MUSCLE INVOLVED | POSITIVE | 6 | 6/13 ( 46.15 %) | 22.11% - 71.71% |
Table 14
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| NEGATIVE | 153 | 7 |
| POSITIVE | 84 | 6 |
CYSTOSCOPIC FINDINGS OF RE TURBT
Figure 7 CYSTOSCOPIC_FINDING_OF_RE_TURBT Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of CYSTOSCOPIC_FINDING_OF_RE_TURBT categories No growth and Recurrent growth present in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup No growth has highest percentage 200/237 ( 84.39 % ) in group MUSCLE FREE . Subgroup Recurrent growth present has highest percentage 9/13 ( 69.23 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Significant association between CYSTOSCOPIC_FINDING_OF_RE_TURBT and MUSCLE_INVOLVEMENT. The chi-square statistic was 20.16 . The degree of freedom was 1 and P value was <0.001 .Contingency and Proportion table are shown below.
Table 15
| MUSCLE_INVOLVEMENT | CYSTOSCOPIC_FINDING_OF_RE_TURBT | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | No growth | 200 | 200/237 ( 84.39 %) | 79.36% - 88.58% |
| MUSCLE FREE | Recurrent growth present | 37 | 37/237 ( 15.61 %) | 11.42% - 20.64% |
| MUSCLE INVOLVED | No growth | 4 | 4/13 ( 30.77 %) | 11.39% - 57.7% |
| MUSCLE INVOLVED | Recurrent growth present | 9 | 9/13 ( 69.23 %) | 42.3% - 88.61% |
Table 16
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| No growth | 200 | 4 |
| Recurrent growth present | 37 | 9 |
MUSCLE PRESENT IN PRIMARY SPECIMEN
Figure 8 MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN categories Present and Absent in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup Present has highest percentage 201/237 ( 84.81 % ) in group MUSCLE FREE . Subgroup Absent has highest percentage 7/13 ( 53.85 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test
we found a Significant association between MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN and MUSCLE_INVOLVEMENT. The chi-square statistic was 10.36 . The degree of freedom was 1 and P value was <0.001 .Contingency and Proportion table are shown below
Table 17
| MUSCLE_INVOLVEMENT | MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | Absent | 36 | 36/237 ( 15.19 %) | 11.05% - 20.17% |
| MUSCLE FREE | Present | 201 | 201/237 ( 84.81 %) | 79.83% - 88.95% |
| MUSCLE INVOLVED | Absent | 7 | 7/13 ( 53.85 %) | 28.29% - 77.89% |
| MUSCLE INVOLVED | Present | 6 | 6/13 ( 46.15 %) | 22.11% - 71.71% |
Table 18
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| Absent | 36 | 7 |
| Present | 201 | 6 |
PERIVESICAL FAT STRANDING ON IMAGING
Figure 9 PERIVESICAL FAT STRANDING_ON_IMAGING Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of PERIVESICAL_FAT_STRANDING t in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup Absent has highest percentage 203/237 ( 85.65 % ) in group MUSCLE FREE . Subgroup Present has highest percentage 10/13 ( 76.92 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
e found a Significant association between PERIVESICAL_FAT_STRANDING_ON_IMAGING and MUSCLE_INVOLVEMENT. The chi-square statistic was 29.1 . The degree of freedom was 1 and P value was <0.001 .Contingency and Proportion table are shown below
Table 19
| MUSCLE_INVOLVEMENT | PERIVESICAL_FAT_STRANDING_ON_IMAGING | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | Absent | 203 | 203/237 ( 85.65 %) | 80.77% - 89.67% |
| MUSCLE FREE | Present | 34 | 34/237 ( 14.35 %) | 10.33% - 19.23% |
| MUSCLE INVOLVED | Absent | 3 | 3/13 ( 23.08 %) | 6.97% - 49.74% |
| MUSCLE INVOLVED | Present | 10 | 10/13 ( 76.92 %) | 50.26% - 93.03% |
Table 20
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| Absent | 203 | 3 |
| Present | 34 | 10 |
TYPE OF GROWTH
Figure 10 TYPE_OF_GROWTH Distribution in Our Population
The Dodged bar chart above represents individual counts representing frequency of TYPE_OF_GROWTH categories Papillary,Solid and Carpet in categories MUSCLE FREE and MUSCLE INVOLVED belonging to group MUSCLE_INVOLVEMENT. Subgroup Papillary has highest percentage 189/237 ( 79.75 % ) in group MUSCLE FREE . Subgroup Papillary has highest percentage 11/13 ( 84.62 % ) in group MUSCLE INVOLVED . To formally check for association between groups we performed pearson chi-square test .
we found a Non-significant association between TYPE_OF_GROWTH and MUSCLE_INVOLVEMENT. The chi-square statistic was 0.4 . The degree of freedom was 2 and P value was 0.82 .Contingency and Proportion table are shown below
Table 21
| MUSCLE_INVOLVEMENT | TYPE_OF_GROWTH | n | value | 95 % Confidence Interval |
|---|---|---|---|---|
| MUSCLE FREE | Carpet | 6 | 6/237 ( 2.53 %) | 1.06% - 5.14% |
| MUSCLE FREE | Papillary | 189 | 189/237 ( 79.75 %) | 74.29% - 84.48% |
| MUSCLE FREE | Solid | 42 | 42/237 ( 17.72 %) | 13.27% - 22.96% |
| MUSCLE INVOLVED | Papillary | 11 | 11/13 ( 84.62 %) | 59.1% - 96.66% |
| MUSCLE INVOLVED | Solid | 2 | 2/13 ( 15.38 %) | 3.34% - 40.9% |
Table 22
| MUSCLE FREE | MUSCLE INVOLVED | |
|---|---|---|
| Carpet | 6 | 0 |
| Papillary | 189 | 11 |
| Solid | 42 | 2 |
LOGISTIC REGRESSION
Logistic regression with Univariate and Multivariate odds ratio . With (Muscle involvement at restage TURBT as dependent variable and variables based on presepecified clinical importance and sttaistical significance(p<0.2) as independent variables.
| Dependent: MUSCLE_INVOLVEMENT | MUSCLE FREE | MUSCLE INVOLVED | OR (univariable) | OR (multivariable) | |
|---|---|---|---|---|---|
| AGE | Mean (SD) | 56.2 (13.1) | 53.0 (18.3) | 0.98 (0.94-1.02, p=0.406) | 0.99 (0.95-1.03, p=0.688) |
| TUMOUR_SIZE | < 3 CM | 84 (35.4) | 1 (7.7) |
|
|
| >3 CM | 153 (64.6) | 12 (92.3) | 6.59 (1.26-121.06, p=0.072) | 1.47 (0.17-31.45, p=0.748) | |
| PERIVESICAL_FAT_STRANDING_ON_IMAGING | Absent | 203 (85.7) | 3 (23.1) |
|
|
| Present | 34 (14.3) | 10 (76.9) | 19.90 (5.76-92.19, p<0.001) | 14.92 (2.71-123.49, p=0.004) | |
| SEX | F | 38 (16.0) | 0 (0.0) |
|
|
| M | 199 (84.0) | 13 (100.0) | 20536473.26 (0.00-NA, p=0.992) | 21611750.92 (0.00-NA, p=0.991) | |
| MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN | Absent | 36 (15.2) | 7 (53.8) |
|
|
| Present | 201 (84.8) | 6 (46.2) | 0.15 (0.05-0.49, p=0.001) | 0.17 (0.04-0.68, p=0.012) | |
| BTA_TEST | NEGATIVE | 83 (35.0) | 2 (15.4) |
|
|
| POSITIVE | 154 (65.0) | 11 (84.6) | 2.96 (0.77-19.45, p=0.164) | 0.47 (0.05-4.46, p=0.482) | |
| URINE_FOR_MALIGNANTCYTOLOGY | NEGATIVE | 153 (64.6) | 7 (53.8) |
|
|
| POSITIVE | 84 (35.4) | 6 (46.2) | 1.56 (0.49-4.85, p=0.437) | 1.39 (0.33-6.17, p=0.652) | |
| UPPER_TRACT_ON_IMAGING | HDUN | 7 (3.0) | 4 (30.8) |
|
|
| NORMAL | 230 (97.0) | 9 (69.2) | 0.07 (0.02-0.30, p<0.001) | 0.32 (0.05-1.92, p=0.203) |
Since the number of Outcomes was less .We penalised excessive variance as the results of the penalised logistic regression are as follows
[1] 1.5| Variable | Effect | Lower.0.95 | Upper.0.95 |
|---|---|---|---|
| AGE | 0.8338590 | 0.4414429 | 1.575109 |
| TUMOUR_SIZE - < 3 CM:>3 CM | 0.6247336 | 0.1410979 | 2.766109 |
| PERIVESICAL_FAT_STRANDING_ON_IMAGING - Present:Absent | 6.3607342 | 1.9142678 | 21.135465 |
| SEX - F:M | 0.3655986 | 0.0693721 | 1.926744 |
| MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN - Absent:Present | 3.5804983 | 1.1887718 | 10.784213 |
| BTA_TEST - NEGATIVE:POSITIVE | 0.9440269 | 0.2334379 | 3.817661 |
| URINE_FOR_MALIGNANTCYTOLOGY - POSITIVE:NEGATIVE | 1.1674145 | 0.3802846 | 3.583781 |
| UPPER_TRACT_ON_IMAGING - HDUN:NORMAL | 2.3945838 | 0.6214715 | 9.226540 |
Effect plot
Cox regression, Time to growth
| Dependent: Surv(time, status) | HR (univariable) | HR (multivariable) | |
|---|---|---|---|
| AGE | Mean (SD) | 0.99 (0.95-1.03, p=0.601) | 1.00 (0.96-1.04, p=0.906) |
| TUMOUR_SIZE | < 3 CM |
|
|
| >3 CM | 7.46 (0.96-57.69, p=0.054) | 1.53 (0.12-19.70, p=0.745) | |
| PERIVESICAL_FAT_STRANDING_ON_IMAGING | Absent |
|
|
| Present | 18.73 (4.96-70.69, p<0.001) | 14.73 (1.84-117.71, p=0.011) | |
| SEX | F |
|
|
| M | 88323572.24 (0.00-Inf, p=0.998) | 536652693.35 (0.00-Inf, p=0.998) | |
| MUSCLE_PRESENT_IN_PRIMARY_SPECIMEN | Absent |
|
|
| Present | 0.14 (0.05-0.42, p<0.001) | 0.12 (0.03-0.47, p=0.002) | |
| BTA_TEST | NEGATIVE |
|
|
| POSITIVE | 2.73 (0.61-12.34, p=0.191) | 0.22 (0.02-2.32, p=0.210) | |
| URINE_FOR_MALIGNANTCYTOLOGY | NEGATIVE |
|
|
| POSITIVE | 1.65 (0.54-5.03, p=0.377) | 1.76 (0.40-7.79, p=0.459) | |
| UPPER_TRACT_ON_IMAGING | HDUN |
|
|
| NORMAL | 0.05 (0.01-0.20, p<0.001) | 0.16 (0.03-0.73, p=0.018) |
