Lucrare de licență
Lucrare de licență
Virgina Muresan Morfopat
1 Partea generală
2 Partea specială
2.1 Introducere
2.1.1 Obiective
2.2 Material și metode
2.2.1 Analiza statistică a datelor
Pentru descrierea variabilelor cantitative am folosit histograme și am calculat mediile aritmetice ± deviația standard (DS) [cu intervalul de încredere (IC) 95%], precum și valorile extreme și mediane. Pentru variabilele calitative, am folosit pie-uri sau bar-chart-uri și am calculat frecvențele absolute și relative ale categoriilor formate.
Pentru a studia relațiile dintre variabilele cantitative și cele calitative, am folosit testele T și Mann-Whitney (MW) dacă acestea au fost binare, respectiv ANOVA dacă acestea au avut mai multe categorii. Am prezentat valorile p generate de aceste teste precum și mediile ± DS ale grupurilor și diferența mediilor cu IC95% asociat. Am prezentat grafic rezultatele sub forma unor box-plot-uri. Pentru a studia relațiile dintre variabilele cantitative am folosit coeficientul de corelație Spearman (R), cu valoarea p asociata și am prezentat grafic relațiile sub forma unor scatter-plot-uri pe care am adăugat linia de regresie cu IC95%. Pentru a descrie relațiile dintre variabilele calitative am folosit testul Chi2 sau Fisher și indicatorii Cramer phi sau V și Odds-Ratio (OR) / Risc relativ (RR) cu IC95%. Am prezentat grafic rezultatele sub forma unor bar-chart-uri.
Am folosit Microsot Excel 2016 pentru managementul bazei de date. Pentru toate analizele statistice și graficele ulterioare am folosit R 3.6.0 [1]. Am considerat p < 0.05 ca fiind semnificativ statistic și p < 0.1 ca prezentând doar o tendință spre semnificativitate statistică.
2.3 Rezultate
2.3.1 Harta
[1] TRUE Shapefile type: Polygon, (5), # of Shapes: 1522 Shapefile type: Polygon, (5), # of Shapes: 1522
Figura 1: Distribuția geografică a cazurilor
2.3.2 Varsta (tabele)
Tabel 1: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Vârsta (ani) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 129 (100.0%) | 47.29 ±13.5 | 44.0 (22.0:82.0) |
Grup: Diagnostic (Kruskal-Wallis rank sum test: p<0.001) | |||
Leiomiom | 69 (53.5%) | 40.91 ±8.5 | 41.0 (22.0:65.0) |
Leiomiosarcom | 29 (22.5%) | 60.10 ±10.6 | 61.0 (39.0:82.0) |
Sarcom stromal endometrial | 31 (24.0%) | 49.52 ±15.8 | 45.0 (29.0:79.0) |
Grup: Malignitate (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
malign | 60 (46.5%) | 54.63 ±14.4 | 53.0 (29.0:82.0) |
benign | 69 (53.5%) | 40.91 ±8.5 | 41.0 (22.0:65.0) |
Grup: Metoda de detecție (Kruskal-Wallis rank sum test: p=0.023) | |||
histerectomie | 100 (77.5%) | 49.12 ±14.0 | 46.5 (22.0:82.0) |
histeroscopie | 8 (6.2%) | 39.25 ±7.5 | 41.5 (22.0:45.0) |
miomectomie | 21 (16.3%) | 41.67 ±9.6 | 41.0 (27.0:64.0) |
Tabel 2: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Vârsta (ani) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 129 (100.0%) | 47.29 ±13.5 | 44.0 (22.0:82.0) |
Grup: Județ (Kruskal-Wallis rank sum test: p=0.764) | |||
AB | 4 (3.1%) | 40.50 ±9.8 | 44.0 (26.0:48.0) |
BC | 1 (0.8%) | 48.00 ±NA | 48.0 (48.0:48.0) |
BH | 6 (4.7%) | 55.17 ±17.7 | 47.5 (38.0:78.0) |
BN | 10 (7.8%) | 39.90 ±15.5 | 35.5 (22.0:73.0) |
BT | 1 (0.8%) | 45.00 ±NA | 45.0 (45.0:45.0) |
BV | 2 (1.6%) | 66.50 ±4.9 | 66.5 (63.0:70.0) |
CJ | 63 (48.8%) | 46.70 ±13.1 | 43.0 (29.0:79.0) |
GJ | 3 (2.3%) | 52.67 ±14.7 | 58.0 (36.0:64.0) |
GL | 1 (0.8%) | 52.00 ±NA | 52.0 (52.0:52.0) |
HD | 6 (4.7%) | 54.00 ±15.6 | 46.0 (43.0:82.0) |
MH | 1 (0.8%) | 44.00 ±NA | 44.0 (44.0:44.0) |
MM | 7 (5.4%) | 47.00 ±10.6 | 48.0 (31.0:65.0) |
MS | 2 (1.6%) | 36.00 ±19.8 | 36.0 (22.0:50.0) |
NT | 2 (1.6%) | 53.00 ±22.6 | 53.0 (37.0:69.0) |
SB | 1 (0.8%) | 39.00 ±NA | 39.0 (39.0:39.0) |
SJ | 7 (5.4%) | 47.71 ±13.5 | 42.0 (32.0:68.0) |
SM | 7 (5.4%) | 50.43 ±13.3 | 46.0 (40.0:77.0) |
SV | 3 (2.3%) | 50.00 ±13.0 | 50.0 (37.0:63.0) |
TM | 1 (0.8%) | 39.00 ±NA | 39.0 (39.0:39.0) |
VL | 1 (0.8%) | 41.00 ±NA | 41.0 (41.0:41.0) |
Tabel 3: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Vârsta (ani) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 129 (100.0%) | 47.29 ±13.5 | 44.0 (22.0:82.0) |
Grup: Hemoragii (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 76 (58.9%) | 51.79 ±14.3 | 50.5 (26.0:82.0) |
nu | 53 (41.1%) | 40.85 ±9.0 | 41.0 (22.0:65.0) |
Grup: Necroză (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 75 (58.1%) | 51.73 ±14.5 | 51.0 (26.0:82.0) |
nu | 54 (41.9%) | 41.13 ±8.9 | 41.5 (22.0:65.0) |
Grup: Atipii (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 61 (47.3%) | 54.46 ±14.4 | 53.0 (29.0:82.0) |
nu | 68 (52.7%) | 40.87 ±8.6 | 41.0 (22.0:65.0) |
Tabel 4: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Vârsta (ani) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 129 (100.0%) | 47.29 ±13.5 | 44.0 (22.0:82.0) |
Grup: Localizare (Kruskal-Wallis rank sum test: p=0.357) | |||
intramural | 81 (62.8%) | 47.90 ±13.6 | 45.0 (22.0:82.0) |
corp uterin | 30 (23.3%) | 48.53 ±15.1 | 44.5 (29.0:78.0) |
submucos | 10 (7.8%) | 39.60 ±7.5 | 40.5 (22.0:50.0) |
subseros | 8 (6.2%) | 46.12 ±9.9 | 44.5 (34.0:59.0) |
Grup: Mutiple/unice (Wilcoxon rank sum test with continuity correction: p=0.030) | |||
multiple | 47 (36.4%) | 43.02 ±8.5 | 43.0 (22.0:65.0) |
unice | 82 (63.6%) | 49.74 ±15.2 | 48.0 (22.0:82.0) |
Tabel 5: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Vârsta (ani) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 129 (100.0%) | 47.29 ±13.5 | 44.0 (22.0:82.0) |
Grup: Markeri imunohistochimici (Wilcoxon rank sum test with continuity correction: p=0.164) | |||
da | 33 (25.6%) | 50.21 ±14.2 | 50.0 (29.0:79.0) |
nu | 96 (74.4%) | 46.29 ±13.2 | 44.0 (22.0:82.0) |
2.3.3 Malignitate
Vârsta pacienților (N=129) a avut valori între 22 și 82 ani (mediana: 44) cu o medie de 47.29 ±13.5 ani. Vârsta pacienților cu Malignitate: malign (N=60, 46.5%) a avut valori între 29 și 82 ani (mediana: 53) cu o medie de 54.63 ±14.4 ani. Vârsta pacienților cu Malignitate: benign (N=69, 53.5%) a avut valori între 22 și 65 ani (mediana: 41) cu o medie de 40.91 ±8.52 ani. Această diferență de 13.7 ani a fost semnificativă statistic (p<0.001) conform testului Mann-Whitney.
Figura 1: Distribuția pacienților în funcție de Malignitate.
Figura 2: Histograma varstei pacienților, in functie de malignitatea tumorii (| media, ¦ mediana).
2.3.4 Diagnostic
Figura 3: Distribuția pacienților în funcție de Diagnostic.
Figura 4: Distriutia pacientilor in functie de Diagnostic.
Figura 5: Histograma varstei pacienților, in functie de diagnostic (| media, ¦ mediana).
2.3.5 Metoda de detectie
Figura 6: Distriutia pacientilor in functie de Metoda de detectie.
Figura 7: Histograma varstei pacienților, in functie de Metoda de detecție (| media, ¦ mediana).
2.3.6 Localizare
Figura 8: Distriutia pacientilor in functie de Localizare.
Figura 9: Histograma varstei pacienților, in functie de Localizarea tumorii (| media, ¦ mediana).
2.3.7 Nr. leziuni
Figura 10: Distribuția pacienților în funcție de Mutiple/unice.
Figura 11: Histograma varstei pacienților, in funcție de numărul de leziuni (| media, ¦ mediana).
2.3.8 IHC
Figura 12: Distribuția pacienților în funcție de Efectuarea IHC.
Figura 13: Histograma varstei pacienților, în funcție de efectuarea IHC (| media, ¦ mediana).
Figura 14: IHC.
Figura 15: Distribuția pacienților în funcție de CD10.
Figura 16: Distribuția pacienților în funcție de p53.
Figura 17: Distribuția pacienților în funcție de Ki 67.
Figura 18: Distribuția pacienților în funcție de CK AE1/AE3.
Figura 19: Distribuția pacienților în funcție de SMA.
Figura 20: Distribuția pacienților în funcție de RE, RP.
Figura 21: Distribuția pacienților în funcție de CEA.
Figura 22: Distribuția pacienților în funcție de CA125.
Figura 23: Distribuția pacienților în funcție de S100, HMB45, Actina.
2.3.9 Dimensiunea
Tabel 6: Descrierea caracteristicilor pacientilor in raport cu dimesniunea tumorii.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Dimensiune (cm) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 98 (100.0%) | 7.44 ±5.1 | 6.0 (0.5:29.0) |
Grup: Diagnostic (Kruskal-Wallis rank sum test: p<0.001) | |||
Leiomiom | 69 (70.4%) | 5.02 ±2.5 | 4.2 (0.5:12.5) |
Leiomiosarcom | 29 (29.6%) | 13.21 ±5.1 | 14.0 (6.0:29.0) |
Sarcom stromal endometrial | 0 (0.0%) | NaN ±NA | NA (Inf:-Inf) |
Grup: Malignitate (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
malign | 29 (29.6%) | 13.21 ±5.1 | 14.0 (6.0:29.0) |
benign | 69 (70.4%) | 5.02 ±2.5 | 4.2 (0.5:12.5) |
Grup: Metoda de detecție (Kruskal-Wallis rank sum test: p=0.540) | |||
histerectomie | 70 (71.4%) | 8.08 ±5.8 | 6.5 (0.5:29.0) |
histeroscopie | 8 (8.2%) | 5.94 ±2.2 | 5.5 (3.0:9.0) |
miomectomie | 20 (20.4%) | 5.80 ±2.2 | 5.8 (3.0:10.5) |
Tabel 2: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Dimensiune (cm) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 98 (100.0%) | 7.44 ±5.1 | 6.0 (0.5:29.0) |
Grup: Județ (Kruskal-Wallis rank sum test: p=0.220) | |||
AB | 4 (4.1%) | 5.62 ±1.8 | 5.2 (4.0:8.0) |
BC | 1 (1.0%) | 10.00 ±NA | 10.0 (10.0:10.0) |
BH | 5 (5.1%) | 4.53 ±1.3 | 4.0 (3.0:6.0) |
BN | 8 (8.2%) | 6.62 ±4.1 | 5.2 (3.0:16.0) |
BT | 0 (0.0%) | NaN ±NA | NA (Inf:-Inf) |
BV | 2 (2.0%) | 17.50 ±4.9 | 17.5 (14.0:21.0) |
CJ | 44 (44.9%) | 7.02 ±4.8 | 6.0 (0.5:20.0) |
GJ | 2 (2.0%) | 5.25 ±3.9 | 5.2 (2.5:8.0) |
GL | 1 (1.0%) | 15.00 ±NA | 15.0 (15.0:15.0) |
HD | 4 (4.1%) | 14.25 ±10.7 | 12.0 (4.0:29.0) |
MH | 1 (1.0%) | 3.50 ±NA | 3.5 (3.5:3.5) |
MM | 6 (6.1%) | 6.67 ±4.0 | 6.8 (2.0:12.0) |
MS | 2 (2.0%) | 2.80 ±1.7 | 2.8 (1.6:4.0) |
NT | 2 (2.0%) | 10.50 ±4.9 | 10.5 (7.0:14.0) |
SB | 1 (1.0%) | 4.00 ±NA | 4.0 (4.0:4.0) |
SJ | 5 (5.1%) | 7.36 ±4.2 | 7.3 (3.5:14.0) |
SM | 7 (7.1%) | 8.64 ±4.9 | 10.0 (3.0:17.0) |
SV | 2 (2.0%) | 10.00 ±4.2 | 10.0 (7.0:13.0) |
TM | 1 (1.0%) | 3.50 ±NA | 3.5 (3.5:3.5) |
VL | 0 (0.0%) | NaN ±NA | NA (Inf:-Inf) |
Tabel 7: Descrierea caracteristicilor pacientilor in raport cu dimesniunea tumorii.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Dimensiune (cm) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 98 (100.0%) | 7.44 ±5.1 | 6.0 (0.5:29.0) |
Grup: Hemoragii (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 45 (45.9%) | 10.50 ±5.6 | 9.0 (1.2:29.0) |
nu | 53 (54.1%) | 4.84 ±2.6 | 4.0 (0.5:12.5) |
Grup: Necroză (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 44 (44.9%) | 10.41 ±5.8 | 9.0 (1.2:29.0) |
nu | 54 (55.1%) | 5.02 ±2.6 | 4.1 (0.5:12.5) |
Grup: Atipii (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
da | 30 (30.6%) | 12.88 ±5.3 | 13.5 (3.5:29.0) |
nu | 68 (69.4%) | 5.04 ±2.5 | 4.3 (0.5:12.5) |
Tabel 8: Descrierea caracteristicilor pacientilor in raport cu dimesniunea tumorii.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Dimensiune (cm) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 98 (100.0%) | 7.44 ±5.1 | 6.0 (0.5:29.0) |
Grup: Localizare (Kruskal-Wallis rank sum test: p=0.087) | |||
intramural | 80 (81.6%) | 7.83 ±5.3 | 6.8 (0.5:29.0) |
corp uterin | 0 (0.0%) | NaN ±NA | NA (Inf:-Inf) |
submucos | 10 (10.2%) | 6.45 ±3.9 | 5.2 (3.0:15.0) |
subseros | 8 (8.2%) | 4.81 ±4.2 | 4.0 (1.5:15.0) |
Grup: Mutiple/unice (Wilcoxon rank sum test with continuity correction: p<0.001) | |||
multiple | 47 (48.0%) | 4.73 ±2.6 | 4.0 (0.5:12.5) |
unice | 51 (52.0%) | 9.95 ±5.6 | 9.0 (2.0:29.0) |
Tabel 5: Descrierea caracteristicilor pacientilor in raport cu varsta.
Subset | N | Media ±SD | Med (Min:Max) |
Grup: Dimensiune (cm) (Shapiro-Wilk normality test: p<0.001) | |||
(total) | 98 (100.0%) | 7.44 ±5.1 | 6.0 (0.5:29.0) |
Grup: Markeri imunohistochimici (Wilcoxon rank sum test with continuity correction: p=0.179) | |||
da | 9 (9.2%) | 11.56 ±8.8 | 10.0 (3.0:29.0) |
nu | 89 (90.8%) | 7.03 ±4.4 | 6.0 (0.5:21.0) |
Dimesniuena tumorii se corelează semnificativ statistic cu vârsta mai înaintată (R Spearman = 0.497, p<0.001). Fiecare an de viață creste deimnsiuea medie cu 0.218 cm.
Figura 24: Rela'ia dintre varsta si dimensiunea tumorii.
Call:
lm(formula = baza_de_date$`Dimensiune (cm)` ~ baza_de_date$Varsta)
Coefficients:
(Intercept) baza_de_date$Varsta
-2.701 0.218 Figura 25: Histograma dimensiunii tumorilor, in functie de malignitatea tumorii (| media, ¦ mediana).
Figura 26: Histograma dimensiunii tumorilor, in functie de diagnostic (| media, ¦ mediana).
Figura 27: Histograma dimensiunii tumorilor, in functie de Metoda de detecție (| media, ¦ mediana).
Figura 28: Histograma dimensiunii tumorilor, in functie de Localizarea tumorii (| media, ¦ mediana).
Figura 29: Histograma dimensiunii tumorilor, in funcție de numărul de leziuni (| media, ¦ mediana).
Figura 30: Histograma dimensiunii tumorilor, în funcție de efectuarea IHC (| media, ¦ mediana).
3 Referințe
- R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. URL https://www.R-project.org/.
4 Extra
Tabel 9: All vs.Diagnostic
Factor | Levels | Total | Leiomiom | Leiomiosarcom | Sarcom stromal endometrial | Statistics |
Diagnostic | 129 | 69 (53.5%) | 29 (22.5%) | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 44 (22:82) | 41 (22:65) | 61 (39:82) | 45 (29:79) | Kruskal-Wallis: p<0.001 |
Mean ±SD | 47.29 ±13.5 | 40.91 ±8.52 | 60.10 ±10.6 | 49.52 ±15.8 | ||
Malignitate | malign | 60 (46.5%) | 0 | 29 (100.0%) | 31 (100.0%) | V=1.00 (p<0.001) |
benign | 69 (53.5%) | 69 (100.0%) | 0 | 0 | ||
Hemoragii | 76 (58.9%) | 16 (23.2%) | 29 (100.0%) | 31 (100.0%) | V=0.78 (p<0.001) | |
Necroză | 75 (58.1%) | 15 (21.7%) | 29 (100.0%) | 31 (100.0%) | V=0.79 (p<0.001) | |
Atipii | 61 (47.3%) | 1 (1.4%) | 29 (100.0%) | 31 (100.0%) | V=0.98 (p<0.001) | |
Metoda de detecție | histerectomie | 100 (77.5%) | 41 (59.4%) | 29 (100.0%) | 30 (96.8%) | V=0.33 (p<0.001) |
histeroscopie | 8 (6.2%) | 8 (11.6%) | 0 | 0 | ||
miomectomie | 21 (16.3%) | 20 (29.0%) | 0 | 1 (3.2%) | ||
Județ | AB | 4 (3.1%) | 4 (5.8%) | 0 | 0 | V=0.39 (p=0.452) |
BC | 1 (0.8%) | 0 | 1 (3.4%) | 0 | ||
BH | 6 (4.7%) | 4 (5.8%) | 1 (3.4%) | 1 (3.2%) | ||
BN | 10 (7.8%) | 7 (10.1%) | 1 (3.4%) | 2 (6.5%) | ||
BT | 1 (0.8%) | 0 | 0 | 1 (3.2%) | ||
BV | 2 (1.6%) | 0 | 2 (6.9%) | 0 | ||
CJ | 63 (48.8%) | 32 (46.4%) | 12 (41.4%) | 19 (61.3%) | ||
GJ | 3 (2.3%) | 1 (1.4%) | 1 (3.4%) | 1 (3.2%) | ||
GL | 1 (0.8%) | 0 | 1 (3.4%) | 0 | ||
HD | 6 (4.7%) | 2 (2.9%) | 2 (6.9%) | 2 (6.5%) | ||
MH | 1 (0.8%) | 1 (1.4%) | 0 | 0 | ||
MM | 7 (5.4%) | 5 (7.2%) | 1 (3.4%) | 1 (3.2%) | ||
MS | 2 (1.6%) | 2 (2.9%) | 0 | 0 | ||
NT | 2 (1.6%) | 1 (1.4%) | 1 (3.4%) | 0 | ||
SB | 1 (0.8%) | 1 (1.4%) | 0 | 0 | ||
SJ | 7 (5.4%) | 3 (4.3%) | 2 (6.9%) | 2 (6.5%) | ||
SM | 7 (5.4%) | 4 (5.8%) | 3 (10.3%) | 0 | ||
SV | 3 (2.3%) | 1 (1.4%) | 1 (3.4%) | 1 (3.2%) | ||
TM | 1 (0.8%) | 1 (1.4%) | 0 | 0 | ||
VL | 1 (0.8%) | 0 | 0 | 1 (3.2%) | ||
Dimensiune (cm) | *M(R) | 6 (0.5:29) | 4.2 (0.5:12.5) | 14 (6:29) | MW: p<0.001 | |
Mean ±SD | 7.44 ±5.1 | 5.02 ±2.51 | 13.21 ±5.08 | |||
Localizare | intramural | 81 (62.8%) | 53 (76.8%) | 27 (93.1%) | 1 (3.2%) | V=0.71 (p<0.001) |
corp uterin | 30 (23.3%) | 0 | 0 | 30 (96.8%) | ||
submucos | 10 (7.8%) | 9 (13.0%) | 1 (3.4%) | 0 | ||
subseros | 8 (6.2%) | 7 (10.1%) | 1 (3.4%) | 0 | ||
Mutiple/unice | multiple | 47 (36.4%) | 47 (68.1%) | 0 | 0 | V=0.71 (p<0.001) |
unice | 82 (63.6%) | 22 (31.9%) | 29 (100.0%) | 31 (100.0%) | ||
Markeri imunohistochimici | 33 (25.6%) | 5 (7.2%) | 4 (13.8%) | 24 (77.4%) | V=0.67 (p<0.001) | |
CD10 | 1 (3.0%) | 1 (20.0%) | 0 | 0 | V=0.42 (p=0.056) | |
p53 | 1 (3.0%) | 1 (20.0%) | 0 | 0 | V=0.42 (p=0.056) | |
Ki 67 | 8 (24.2%) | 4 (80.0%) | 4 (100.0%) | 0 | V=0.93 (p<0.001) | |
CK AE1/AE3 | 2 (6.1%) | 1 (20.0%) | 1 (25.0%) | 0 | V=0.42 (p=0.056) | |
SMA | 3 (9.1%) | 0 | 3 (75.0%) | 0 | V=0.85 (p<0.001) | |
RE, RP | 2 (6.1%) | 2 (40.0%) | 0 | 0 | V=0.60 (p=0.003) | |
CEA | 1 (3.0%) | 1 (20.0%) | 0 | 0 | V=0.42 (p=0.056) | |
CA125 | 1 (3.0%) | 1 (20.0%) | 0 | 0 | V=0.42 (p=0.056) | |
S100, HMB45, Actina | 1 (3.0%) | 1 (20.0%) | 0 | 0 | V=0.42 (p=0.056) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | ||||||
Tabel 10: All vs.Malignitate
Factor | Levels | malign | benign | Total | Statistics |
Malignitate | 60 (46.5%) | 69 (53.5%) | 129 | ||
Diagnostic | Leiomiom | 0 | 69 (100.0%) | 69 (53.5%) | V=1.00 (p<0.001) |
Leiomiosarcom | 29 (48.3%) | 0 | 29 (22.5%) | ||
Sarcom stromal endometrial | 31 (51.7%) | 0 | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 53 (29:82) | 41 (22:65) | 44 (22:82) | MW: p<0.001 |
Mean ±SD | 54.63 ±14.4 | 40.91 ±8.52 | 47.29 ±13.5 | ||
Hemoragii | 60 (100.0%) | 16 (23.2%) | 76 (58.9%) | OR=392.33 [22.98, 6 697.88], RR=4.31 [2.83, 6.57] (p<0.001) | |
Necroză | 60 (100.0%) | 15 (21.7%) | 75 (58.1%) | OR=425.45 [24.86, 7 280.82], RR=4.60 [2.97, 7.13] (p<0.001) | |
Atipii | 60 (100.0%) | 1 (1.4%) | 61 (47.3%) | OR=5 525.67 [220.95, Inf], RR=69.00 [14.17, 335.88] (p<0.001) | |
Metoda de detecție | histerectomie | 59 (98.3%) | 41 (59.4%) | 100 (77.5%) | V=0.47 (p<0.001) |
histeroscopie | 0 | 8 (11.6%) | 8 (6.2%) | ||
miomectomie | 1 (1.7%) | 20 (29.0%) | 21 (16.3%) | ||
Județ | AB | 0 | 4 (5.8%) | 4 (3.1%) | V=0.39 (p=0.416) |
BC | 1 (1.7%) | 0 | 1 (0.8%) | ||
BH | 2 (3.3%) | 4 (5.8%) | 6 (4.7%) | ||
BN | 3 (5.0%) | 7 (10.1%) | 10 (7.8%) | ||
BT | 1 (1.7%) | 0 | 1 (0.8%) | ||
BV | 2 (3.3%) | 0 | 2 (1.6%) | ||
CJ | 31 (51.7%) | 32 (46.4%) | 63 (48.8%) | ||
GJ | 2 (3.3%) | 1 (1.4%) | 3 (2.3%) | ||
GL | 1 (1.7%) | 0 | 1 (0.8%) | ||
HD | 4 (6.7%) | 2 (2.9%) | 6 (4.7%) | ||
MH | 0 | 1 (1.4%) | 1 (0.8%) | ||
MM | 2 (3.3%) | 5 (7.2%) | 7 (5.4%) | ||
MS | 0 | 2 (2.9%) | 2 (1.6%) | ||
NT | 1 (1.7%) | 1 (1.4%) | 2 (1.6%) | ||
SB | 0 | 1 (1.4%) | 1 (0.8%) | ||
SJ | 4 (6.7%) | 3 (4.3%) | 7 (5.4%) | ||
SM | 3 (5.0%) | 4 (5.8%) | 7 (5.4%) | ||
SV | 2 (3.3%) | 1 (1.4%) | 3 (2.3%) | ||
TM | 0 | 1 (1.4%) | 1 (0.8%) | ||
VL | 1 (1.7%) | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 14 (6:29) | 4.2 (0.5:12.5) | 6 (0.5:29) | MW: p<0.001 |
Mean ±SD | 13.21 ±5.08 | 5.02 ±2.51 | 7.44 ±5.1 | ||
Localizare | intramural | 28 (46.7%) | 53 (76.8%) | 81 (62.8%) | V=0.61 (p<0.001) |
corp uterin | 30 (50.0%) | 0 | 30 (23.3%) | ||
submucos | 1 (1.7%) | 9 (13.0%) | 10 (7.8%) | ||
subseros | 1 (1.7%) | 7 (10.1%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 0 | 47 (68.1%) | 47 (36.4%) | OR=0.00 [0.00, 0.07], RR=0.00 [0.00, 0.00] (p<0.001) |
unice | 60 (100.0%) | 22 (31.9%) | 82 (63.6%) | ||
Markeri imunohistochimici | 28 (46.7%) | 5 (7.2%) | 33 (25.6%) | OR=11.20 [3.95, 31.75], RR=6.44 [2.77, 14.99] (p<0.001) | |
CD10 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
p53 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
Ki 67 | 4 (14.3%) | 4 (80.0%) | 8 (24.2%) | OR=0.04 [0.00, 0.47], RR=0.18 [0.07, 0.44] (p=0.008) | |
CK AE1/AE3 | 1 (3.6%) | 1 (20.0%) | 2 (6.1%) | OR=0.15 [0.01, 2.87], RR=0.18 [0.02, 1.39] (p=0.284) | |
SMA | 3 (10.7%) | 0 | 3 (9.1%) | OR=1.51 [0.07, 33.62], RR=Inf [Inf, Inf] (p=1.000) | |
RE, RP | 0 | 2 (40.0%) | 2 (6.1%) | OR=0.02 [0.00, 0.62], RR=0.00 [0.00, 0.00] (p=0.019) | |
CEA | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
CA125 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
S100, HMB45, Actina | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
Tabel 11: All vs.Hemoragii
Factor | Levels | da | nu | Total | Statistics |
Hemoragii | 76 (58.9%) | 53 (41.1%) | 129 | ||
Diagnostic | Leiomiom | 16 (21.1%) | 53 (100.0%) | 69 (53.5%) | V=0.78 (p<0.001) |
Leiomiosarcom | 29 (38.2%) | 0 | 29 (22.5%) | ||
Sarcom stromal endometrial | 31 (40.8%) | 0 | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 50.5 (26:82) | 41 (22:65) | 44 (22:82) | MW: p<0.001 |
Mean ±SD | 51.79 ±14.3 | 40.85 ±9.01 | 47.29 ±13.5 | ||
Malignitate | malign | 60 (78.9%) | 0 | 60 (46.5%) | OR=392.33 [22.98, 6 697.88], RR=Inf [Inf, Inf] (p<0.001) |
benign | 16 (21.1%) | 53 (100.0%) | 69 (53.5%) | ||
Necroză | 73 (96.1%) | 2 (3.8%) | 75 (58.1%) | OR=620.50 [100.08, 3 847.29], RR=25.45 [7.58, 85.42] (p<0.001) | |
Atipii | 60 (78.9%) | 1 (1.9%) | 61 (47.3%) | OR=195.00 [25.00, 1 521.01], RR=41.84 [8.60, 203.47] (p<0.001) | |
Metoda de detecție | histerectomie | 69 (90.8%) | 31 (58.5%) | 100 (77.5%) | V=0.41 (p<0.001) |
histeroscopie | 4 (5.3%) | 4 (7.5%) | 8 (6.2%) | ||
miomectomie | 3 (3.9%) | 18 (34.0%) | 21 (16.3%) | ||
Județ | AB | 1 (1.3%) | 3 (5.7%) | 4 (3.1%) | V=0.40 (p=0.381) |
BC | 1 (1.3%) | 0 | 1 (0.8%) | ||
BH | 2 (2.6%) | 4 (7.5%) | 6 (4.7%) | ||
BN | 5 (6.6%) | 5 (9.4%) | 10 (7.8%) | ||
BT | 1 (1.3%) | 0 | 1 (0.8%) | ||
BV | 2 (2.6%) | 0 | 2 (1.6%) | ||
CJ | 40 (52.6%) | 23 (43.4%) | 63 (48.8%) | ||
GJ | 2 (2.6%) | 1 (1.9%) | 3 (2.3%) | ||
GL | 1 (1.3%) | 0 | 1 (0.8%) | ||
HD | 5 (6.6%) | 1 (1.9%) | 6 (4.7%) | ||
MH | 0 | 1 (1.9%) | 1 (0.8%) | ||
MM | 4 (5.3%) | 3 (5.7%) | 7 (5.4%) | ||
MS | 0 | 2 (3.8%) | 2 (1.6%) | ||
NT | 1 (1.3%) | 1 (1.9%) | 2 (1.6%) | ||
SB | 0 | 1 (1.9%) | 1 (0.8%) | ||
SJ | 4 (5.3%) | 3 (5.7%) | 7 (5.4%) | ||
SM | 3 (3.9%) | 4 (7.5%) | 7 (5.4%) | ||
SV | 3 (3.9%) | 0 | 3 (2.3%) | ||
TM | 0 | 1 (1.9%) | 1 (0.8%) | ||
VL | 1 (1.3%) | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 9 (1.2:29) | 4 (0.5:12.5) | 6 (0.5:29) | MW: p<0.001 |
Mean ±SD | 10.50 ±5.64 | 4.84 ±2.56 | 7.44 ±5.1 | ||
Localizare | intramural | 37 (48.7%) | 44 (83.0%) | 81 (62.8%) | V=0.47 (p<0.001) |
corp uterin | 30 (39.5%) | 0 | 30 (23.3%) | ||
submucos | 6 (7.9%) | 4 (7.5%) | 10 (7.8%) | ||
subseros | 3 (3.9%) | 5 (9.4%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 12 (15.8%) | 35 (66.0%) | 47 (36.4%) | OR=0.10 [0.04, 0.22], RR=0.24 [0.14, 0.41] (p<0.001) |
unice | 64 (84.2%) | 18 (34.0%) | 82 (63.6%) | ||
Markeri imunohistochimici | 29 (38.2%) | 4 (7.5%) | 33 (25.6%) | OR=7.56 [2.47, 23.15], RR=5.06 [2.00, 12.79] (p<0.001) | |
CD10 | 0 | 1 (25.0%) | 1 (3.0%) | OR=0.04 [0.00, 1.17], RR=0.00 [0.00, 0.00] (p=0.121) | |
p53 | 0 | 1 (25.0%) | 1 (3.0%) | OR=0.04 [0.00, 1.17], RR=0.00 [0.00, 0.00] (p=0.121) | |
Ki 67 | 5 (17.2%) | 3 (75.0%) | 8 (24.2%) | OR=0.07 [0.01, 0.81], RR=0.23 [0.10, 0.53] (p=0.036) | |
CK AE1/AE3 | 1 (3.4%) | 1 (25.0%) | 2 (6.1%) | OR=0.11 [0.01, 2.19], RR=0.14 [0.02, 1.03] (p=0.231) | |
SMA | 3 (10.3%) | 0 | 3 (9.1%) | OR=1.19 [0.05, 27.11], RR=Inf [Inf, Inf] (p=1.000) | |
RE, RP | 1 (3.4%) | 1 (25.0%) | 2 (6.1%) | OR=0.11 [0.01, 2.19], RR=0.14 [0.02, 1.03] (p=0.231) | |
CEA | 1 (3.4%) | 0 | 1 (3.0%) | OR=0.47 [0.02, 13.52], RR=Inf [Inf, Inf] (p=1.000) | |
CA125 | 1 (3.4%) | 0 | 1 (3.0%) | OR=0.47 [0.02, 13.52], RR=Inf [Inf, Inf] (p=1.000) | |
S100, HMB45, Actina | 0 | 1 (25.0%) | 1 (3.0%) | OR=0.04 [0.00, 1.17], RR=0.00 [0.00, 0.00] (p=0.121) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
Tabel 12: All vs.Necroză
Factor | Levels | da | nu | Total | Statistics |
Necroză | 75 (58.1%) | 54 (41.9%) | 129 | ||
Diagnostic | Leiomiom | 15 (20.0%) | 54 (100.0%) | 69 (53.5%) | V=0.79 (p<0.001) |
Leiomiosarcom | 29 (38.7%) | 0 | 29 (22.5%) | ||
Sarcom stromal endometrial | 31 (41.3%) | 0 | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 51 (26:82) | 41.5 (22:65) | 44 (22:82) | MW: p<0.001 |
Mean ±SD | 51.73 ±14.5 | 41.13 ±8.91 | 47.29 ±13.5 | ||
Malignitate | malign | 60 (80.0%) | 0 | 60 (46.5%) | OR=425.45 [24.86, 7 280.82], RR=Inf [Inf, Inf] (p<0.001) |
benign | 15 (20.0%) | 54 (100.0%) | 69 (53.5%) | ||
Hemoragii | 73 (97.3%) | 3 (5.6%) | 76 (58.9%) | OR=620.50 [100.08, 3 847.29], RR=17.52 [6.36, 48.28] (p<0.001) | |
Atipii | 60 (80.0%) | 1 (1.9%) | 61 (47.3%) | OR=212.00 [27.08, 1 659.50], RR=43.20 [8.88, 210.11] (p<0.001) | |
Metoda de detecție | histerectomie | 68 (90.7%) | 32 (59.3%) | 100 (77.5%) | V=0.38 (p<0.001) |
histeroscopie | 3 (4.0%) | 5 (9.3%) | 8 (6.2%) | ||
miomectomie | 4 (5.3%) | 17 (31.5%) | 21 (16.3%) | ||
Județ | AB | 1 (1.3%) | 3 (5.6%) | 4 (3.1%) | V=0.39 (p=0.408) |
BC | 1 (1.3%) | 0 | 1 (0.8%) | ||
BH | 2 (2.7%) | 4 (7.4%) | 6 (4.7%) | ||
BN | 5 (6.7%) | 5 (9.3%) | 10 (7.8%) | ||
BT | 1 (1.3%) | 0 | 1 (0.8%) | ||
BV | 2 (2.7%) | 0 | 2 (1.6%) | ||
CJ | 39 (52.0%) | 24 (44.4%) | 63 (48.8%) | ||
GJ | 3 (4.0%) | 0 | 3 (2.3%) | ||
GL | 1 (1.3%) | 0 | 1 (0.8%) | ||
HD | 5 (6.7%) | 1 (1.9%) | 6 (4.7%) | ||
MH | 0 | 1 (1.9%) | 1 (0.8%) | ||
MM | 4 (5.3%) | 3 (5.6%) | 7 (5.4%) | ||
MS | 0 | 2 (3.7%) | 2 (1.6%) | ||
NT | 1 (1.3%) | 1 (1.9%) | 2 (1.6%) | ||
SB | 0 | 1 (1.9%) | 1 (0.8%) | ||
SJ | 4 (5.3%) | 3 (5.6%) | 7 (5.4%) | ||
SM | 3 (4.0%) | 4 (7.4%) | 7 (5.4%) | ||
SV | 2 (2.7%) | 1 (1.9%) | 3 (2.3%) | ||
TM | 0 | 1 (1.9%) | 1 (0.8%) | ||
VL | 1 (1.3%) | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 9 (1.2:29) | 4.1 (0.5:12.5) | 6 (0.5:29) | MW: p<0.001 |
Mean ±SD | 10.41 ±5.82 | 5.02 ±2.59 | 7.44 ±5.1 | ||
Localizare | intramural | 36 (48.0%) | 45 (83.3%) | 81 (62.8%) | V=0.47 (p<0.001) |
corp uterin | 30 (40.0%) | 0 | 30 (23.3%) | ||
submucos | 5 (6.7%) | 5 (9.3%) | 10 (7.8%) | ||
subseros | 4 (5.3%) | 4 (7.4%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 11 (14.7%) | 36 (66.7%) | 47 (36.4%) | OR=0.09 [0.04, 0.20], RR=0.22 [0.13, 0.39] (p<0.001) |
unice | 64 (85.3%) | 18 (33.3%) | 82 (63.6%) | ||
Markeri imunohistochimici | 28 (37.3%) | 5 (9.3%) | 33 (25.6%) | OR=5.84 [2.08, 16.39], RR=4.03 [1.74, 9.37] (p<0.001) | |
CD10 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
p53 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
Ki 67 | 4 (14.3%) | 4 (80.0%) | 8 (24.2%) | OR=0.04 [0.00, 0.47], RR=0.18 [0.07, 0.44] (p=0.008) | |
CK AE1/AE3 | 1 (3.6%) | 1 (20.0%) | 2 (6.1%) | OR=0.15 [0.01, 2.87], RR=0.18 [0.02, 1.39] (p=0.284) | |
SMA | 3 (10.7%) | 0 | 3 (9.1%) | OR=1.51 [0.07, 33.62], RR=Inf [Inf, Inf] (p=1.000) | |
RE, RP | 0 | 2 (40.0%) | 2 (6.1%) | OR=0.02 [0.00, 0.62], RR=0.00 [0.00, 0.00] (p=0.019) | |
CEA | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
CA125 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
S100, HMB45, Actina | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
Tabel 13: All vs.Atipii
Factor | Levels | da | nu | Total | Statistics |
Atipii | 61 (47.3%) | 68 (52.7%) | 129 | ||
Diagnostic | Leiomiom | 1 (1.6%) | 68 (100.0%) | 69 (53.5%) | V=0.98 (p<0.001) |
Leiomiosarcom | 29 (47.5%) | 0 | 29 (22.5%) | ||
Sarcom stromal endometrial | 31 (50.8%) | 0 | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 53 (29:82) | 41 (22:65) | 44 (22:82) | MW: p<0.001 |
Mean ±SD | 54.46 ±14.4 | 40.87 ±8.58 | 47.29 ±13.5 | ||
Malignitate | malign | 60 (98.4%) | 0 | 60 (46.5%) | OR=5 525.67 [220.95, Inf], RR=Inf [Inf, Inf] (p<0.001) |
benign | 1 (1.6%) | 68 (100.0%) | 69 (53.5%) | ||
Hemoragii | 60 (98.4%) | 16 (23.5%) | 76 (58.9%) | OR=195.00 [25.00, 1 521.01], RR=4.18 [2.75, 6.37] (p<0.001) | |
Necroză | 60 (98.4%) | 15 (22.1%) | 75 (58.1%) | OR=212.00 [27.08, 1 659.50], RR=4.46 [2.88, 6.91] (p<0.001) | |
Metoda de detecție | histerectomie | 60 (98.4%) | 40 (58.8%) | 100 (77.5%) | V=0.47 (p<0.001) |
histeroscopie | 0 | 8 (11.8%) | 8 (6.2%) | ||
miomectomie | 1 (1.6%) | 20 (29.4%) | 21 (16.3%) | ||
Județ | AB | 0 | 4 (5.9%) | 4 (3.1%) | V=0.39 (p=0.403) |
BC | 1 (1.6%) | 0 | 1 (0.8%) | ||
BH | 2 (3.3%) | 4 (5.9%) | 6 (4.7%) | ||
BN | 3 (4.9%) | 7 (10.3%) | 10 (7.8%) | ||
BT | 1 (1.6%) | 0 | 1 (0.8%) | ||
BV | 2 (3.3%) | 0 | 2 (1.6%) | ||
CJ | 31 (50.8%) | 32 (47.1%) | 63 (48.8%) | ||
GJ | 2 (3.3%) | 1 (1.5%) | 3 (2.3%) | ||
GL | 1 (1.6%) | 0 | 1 (0.8%) | ||
HD | 4 (6.6%) | 2 (2.9%) | 6 (4.7%) | ||
MH | 1 (1.6%) | 0 | 1 (0.8%) | ||
MM | 2 (3.3%) | 5 (7.4%) | 7 (5.4%) | ||
MS | 0 | 2 (2.9%) | 2 (1.6%) | ||
NT | 1 (1.6%) | 1 (1.5%) | 2 (1.6%) | ||
SB | 0 | 1 (1.5%) | 1 (0.8%) | ||
SJ | 4 (6.6%) | 3 (4.4%) | 7 (5.4%) | ||
SM | 3 (4.9%) | 4 (5.9%) | 7 (5.4%) | ||
SV | 2 (3.3%) | 1 (1.5%) | 3 (2.3%) | ||
TM | 0 | 1 (1.5%) | 1 (0.8%) | ||
VL | 1 (1.6%) | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 13.5 (3.5:29) | 4.35 (0.5:12.5) | 6 (0.5:29) | MW: p<0.001 |
Mean ±SD | 12.88 ±5.3 | 5.04 ±2.52 | 7.44 ±5.1 | ||
Localizare | intramural | 29 (47.5%) | 52 (76.5%) | 81 (62.8%) | V=0.60 (p<0.001) |
corp uterin | 30 (49.2%) | 0 | 30 (23.3%) | ||
submucos | 1 (1.6%) | 9 (13.2%) | 10 (7.8%) | ||
subseros | 1 (1.6%) | 7 (10.3%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 1 (1.6%) | 46 (67.6%) | 47 (36.4%) | OR=0.01 [0.00, 0.06], RR=0.02 [0.00, 0.12] (p<0.001) |
unice | 60 (98.4%) | 22 (32.4%) | 82 (63.6%) | ||
Markeri imunohistochimici | 28 (45.9%) | 5 (7.4%) | 33 (25.6%) | OR=10.69 [3.78, 30.27], RR=6.24 [2.68, 14.53] (p<0.001) | |
CD10 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
p53 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
Ki 67 | 4 (14.3%) | 4 (80.0%) | 8 (24.2%) | OR=0.04 [0.00, 0.47], RR=0.18 [0.07, 0.44] (p=0.008) | |
CK AE1/AE3 | 1 (3.6%) | 1 (20.0%) | 2 (6.1%) | OR=0.15 [0.01, 2.87], RR=0.18 [0.02, 1.39] (p=0.284) | |
SMA | 3 (10.7%) | 0 | 3 (9.1%) | OR=1.51 [0.07, 33.62], RR=Inf [Inf, Inf] (p=1.000) | |
RE, RP | 0 | 2 (40.0%) | 2 (6.1%) | OR=0.02 [0.00, 0.62], RR=0.00 [0.00, 0.00] (p=0.019) | |
CEA | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
CA125 | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
S100, HMB45, Actina | 0 | 1 (20.0%) | 1 (3.0%) | OR=0.05 [0.00, 1.50], RR=0.00 [0.00, 0.00] (p=0.152) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
Tabel 14: All vs.Metoda de detecție
Factor | Levels | histerectomie | histeroscopie | miomectomie | Total | Statistics |
Metoda de detecție | 100 (77.5%) | 8 (6.2%) | 21 (16.3%) | 129 | ||
Diagnostic | Leiomiom | 41 (41.0%) | 8 (100.0%) | 20 (95.2%) | 69 (53.5%) | V=0.33 (p<0.001) |
Leiomiosarcom | 29 (29.0%) | 0 | 0 | 29 (22.5%) | ||
Sarcom stromal endometrial | 30 (30.0%) | 0 | 1 (4.8%) | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 46.5 (22:82) | 41.5 (22:45) | 41 (27:64) | 44 (22:82) | Kruskal-Wallis: p=0.023 |
Mean ±SD | 49.12 ±14.0 | 39.25 ±7.54 | 41.67 ±9.63 | 47.29 ±13.5 | ||
Malignitate | malign | 59 (59.0%) | 0 | 1 (4.8%) | 60 (46.5%) | V=0.47 (p<0.001) |
benign | 41 (41.0%) | 8 (100.0%) | 20 (95.2%) | 69 (53.5%) | ||
Hemoragii | 69 (69.0%) | 4 (50.0%) | 3 (14.3%) | 76 (58.9%) | V=0.41 (p<0.001) | |
Necroză | 68 (68.0%) | 3 (37.5%) | 4 (19.0%) | 75 (58.1%) | V=0.38 (p<0.001) | |
Atipii | 60 (60.0%) | 0 | 1 (4.8%) | 61 (47.3%) | V=0.47 (p<0.001) | |
Județ | AB | 3 (3.0%) | 0 | 1 (4.8%) | 4 (3.1%) | V=0.35 (p=0.769) |
BC | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
BH | 6 (6.0%) | 0 | 0 | 6 (4.7%) | ||
BN | 6 (6.0%) | 3 (37.5%) | 1 (4.8%) | 10 (7.8%) | ||
BT | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
BV | 2 (2.0%) | 0 | 0 | 2 (1.6%) | ||
CJ | 48 (48.0%) | 3 (37.5%) | 12 (57.1%) | 63 (48.8%) | ||
GJ | 3 (3.0%) | 0 | 0 | 3 (2.3%) | ||
GL | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
HD | 6 (6.0%) | 0 | 0 | 6 (4.7%) | ||
MH | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
MM | 3 (3.0%) | 1 (12.5%) | 3 (14.3%) | 7 (5.4%) | ||
MS | 2 (2.0%) | 0 | 0 | 2 (1.6%) | ||
NT | 2 (2.0%) | 0 | 0 | 2 (1.6%) | ||
SB | 0 | 0 | 1 (4.8%) | 1 (0.8%) | ||
SJ | 5 (5.0%) | 0 | 2 (9.5%) | 7 (5.4%) | ||
SM | 5 (5.0%) | 1 (12.5%) | 1 (4.8%) | 7 (5.4%) | ||
SV | 3 (3.0%) | 0 | 0 | 3 (2.3%) | ||
TM | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
VL | 1 (1.0%) | 0 | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 6.5 (0.5:29) | 5.5 (3:9) | 5.75 (3:10.5) | 6 (0.5:29) | Kruskal-Wallis: p=0.540 |
Mean ±SD | 8.08 ±5.76 | 5.94 ±2.24 | 5.80 ±2.18 | 7.44 ±5.1 | ||
Localizare | intramural | 59 (59.0%) | 3 (37.5%) | 19 (90.5%) | 81 (62.8%) | V=0.41 (p<0.001) |
corp uterin | 29 (29.0%) | 0 | 1 (4.8%) | 30 (23.3%) | ||
submucos | 5 (5.0%) | 5 (62.5%) | 0 | 10 (7.8%) | ||
subseros | 7 (7.0%) | 0 | 1 (4.8%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 30 (30.0%) | 5 (62.5%) | 12 (57.1%) | 47 (36.4%) | V=0.25 (p=0.018) |
unice | 70 (70.0%) | 3 (37.5%) | 9 (42.9%) | 82 (63.6%) | ||
Markeri imunohistochimici | 30 (30.0%) | 0 | 3 (14.3%) | 33 (25.6%) | V=0.20 (p=0.075) | |
CD10 | 1 (3.3%) | 0 | 0 | 1 (3.0%) | ||
p53 | 1 (3.3%) | 0 | 0 | 1 (3.0%) | ||
Ki 67 | 7 (23.3%) | 0 | 1 (33.3%) | 8 (24.2%) | ||
CK AE1/AE3 | 2 (6.7%) | 0 | 0 | 2 (6.1%) | ||
SMA | 3 (10.0%) | 0 | 0 | 3 (9.1%) | ||
RE, RP | 1 (3.3%) | 0 | 1 (33.3%) | 2 (6.1%) | ||
CEA | 1 (3.3%) | 0 | 0 | 1 (3.0%) | ||
CA125 | 1 (3.3%) | 0 | 0 | 1 (3.0%) | ||
S100, HMB45, Actina | 0 | 0 | 1 (33.3%) | 1 (3.0%) | ||
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | ||||||
Tabel 15: All vs.Localizare
Factor | Levels | intramural | corp uterin | submucos | subseros | Total | Statistics |
Localizare | 81 (62.8%) | 30 (23.3%) | 10 (7.8%) | 8 (6.2%) | 129 | ||
Diagnostic | Leiomiom | 53 (65.4%) | 0 | 9 (90.0%) | 7 (87.5%) | 69 (53.5%) | V=0.71 (p<0.001) |
Leiomiosarcom | 27 (33.3%) | 0 | 1 (10.0%) | 1 (12.5%) | 29 (22.5%) | ||
Sarcom stromal endometrial | 1 (1.2%) | 30 (100.0%) | 0 | 0 | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 45 (22:82) | 44.5 (29:78) | 40.5 (22:50) | 44.5 (34:59) | 44 (22:82) | Kruskal-Wallis: p=0.357 |
Mean ±SD | 47.90 ±13.6 | 48.53 ±15.1 | 39.60 ±7.47 | 46.12 ±9.88 | 47.29 ±13.5 | ||
Malignitate | malign | 28 (34.6%) | 30 (100.0%) | 1 (10.0%) | 1 (12.5%) | 60 (46.5%) | V=0.61 (p<0.001) |
benign | 53 (65.4%) | 0 | 9 (90.0%) | 7 (87.5%) | 69 (53.5%) | ||
Hemoragii | 37 (45.7%) | 30 (100.0%) | 6 (60.0%) | 3 (37.5%) | 76 (58.9%) | V=0.47 (p<0.001) | |
Necroză | 36 (44.4%) | 30 (100.0%) | 5 (50.0%) | 4 (50.0%) | 75 (58.1%) | V=0.47 (p<0.001) | |
Atipii | 29 (35.8%) | 30 (100.0%) | 1 (10.0%) | 1 (12.5%) | 61 (47.3%) | V=0.60 (p<0.001) | |
Metoda de detecție | histerectomie | 59 (72.8%) | 29 (96.7%) | 5 (50.0%) | 7 (87.5%) | 100 (77.5%) | V=0.41 (p<0.001) |
histeroscopie | 3 (3.7%) | 0 | 5 (50.0%) | 0 | 8 (6.2%) | ||
miomectomie | 19 (23.5%) | 1 (3.3%) | 0 | 1 (12.5%) | 21 (16.3%) | ||
Județ | AB | 3 (3.7%) | 0 | 0 | 1 (12.5%) | 4 (3.1%) | V=0.38 (p=0.547) |
BC | 1 (1.2%) | 0 | 0 | 0 | 1 (0.8%) | ||
BH | 4 (4.9%) | 1 (3.3%) | 1 (10.0%) | 0 | 6 (4.7%) | ||
BN | 6 (7.4%) | 2 (6.7%) | 2 (20.0%) | 0 | 10 (7.8%) | ||
BT | 0 | 1 (3.3%) | 0 | 0 | 1 (0.8%) | ||
BV | 2 (2.5%) | 0 | 0 | 0 | 2 (1.6%) | ||
CJ | 39 (48.1%) | 18 (60.0%) | 2 (20.0%) | 4 (50.0%) | 63 (48.8%) | ||
GJ | 1 (1.2%) | 1 (3.3%) | 0 | 1 (12.5%) | 3 (2.3%) | ||
GL | 0 | 0 | 0 | 1 (12.5%) | 1 (0.8%) | ||
HD | 3 (3.7%) | 2 (6.7%) | 1 (10.0%) | 0 | 6 (4.7%) | ||
MH | 1 (1.2%) | 0 | 0 | 0 | 1 (0.8%) | ||
MM | 4 (4.9%) | 1 (3.3%) | 1 (10.0%) | 1 (12.5%) | 7 (5.4%) | ||
MS | 2 (2.5%) | 0 | 0 | 0 | 2 (1.6%) | ||
NT | 2 (2.5%) | 0 | 0 | 0 | 2 (1.6%) | ||
SB | 1 (1.2%) | 0 | 0 | 0 | 1 (0.8%) | ||
SJ | 5 (6.2%) | 2 (6.7%) | 0 | 0 | 7 (5.4%) | ||
SM | 5 (6.2%) | 0 | 2 (20.0%) | 0 | 7 (5.4%) | ||
SV | 1 (1.2%) | 1 (3.3%) | 1 (10.0%) | 0 | 3 (2.3%) | ||
TM | 1 (1.2%) | 0 | 0 | 0 | 1 (0.8%) | ||
VL | 0 | 1 (3.3%) | 0 | 0 | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 6.75 (0.5:29) | 5.25 (3:15) | 4 (1.5:15) | 6 (0.5:29) | Kruskal-Wallis: p=0.087 | |
Mean ±SD | 7.83 ±5.25 | 6.45 ±3.92 | 4.81 ±4.23 | 7.44 ±5.1 | |||
Mutiple/unice | multiple | 36 (44.4%) | 0 | 4 (40.0%) | 7 (87.5%) | 47 (36.4%) | V=0.47 (p<0.001) |
unice | 45 (55.6%) | 30 (100.0%) | 6 (60.0%) | 1 (12.5%) | 82 (63.6%) | ||
Markeri imunohistochimici | 7 (8.6%) | 23 (76.7%) | 1 (10.0%) | 2 (25.0%) | 33 (25.6%) | V=0.65 (p<0.001) | |
CD10 | 1 (14.3%) | 0 | 0 | 0 | 1 (3.0%) | V=0.34 (p=0.280) | |
p53 | 1 (14.3%) | 0 | 0 | 0 | 1 (3.0%) | V=0.34 (p=0.280) | |
Ki 67 | 5 (71.4%) | 0 | 1 (100.0%) | 2 (100.0%) | 8 (24.2%) | V=0.87 (p<0.001) | |
CK AE1/AE3 | 2 (28.6%) | 0 | 0 | 0 | 2 (6.1%) | V=0.49 (p=0.048) | |
SMA | 3 (42.9%) | 0 | 0 | 0 | 3 (9.1%) | V=0.61 (p=0.007) | |
RE, RP | 1 (14.3%) | 0 | 1 (100.0%) | 0 | 2 (6.1%) | V=0.74 (p<0.001) | |
CEA | 0 | 0 | 1 (100.0%) | 0 | 1 (3.0%) | V=1.00 (p<0.001) | |
CA125 | 0 | 0 | 1 (100.0%) | 0 | 1 (3.0%) | V=1.00 (p<0.001) | |
S100, HMB45, Actina | 0 | 0 | 0 | 1 (50.0%) | 1 (3.0%) | V=0.70 (p=0.001) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||||
Tabel 16: All vs.Mutiple/unice
Factor | Levels | multiple | unice | Total | Statistics |
Mutiple/unice | 47 (36.4%) | 82 (63.6%) | 129 | ||
Diagnostic | Leiomiom | 47 (100.0%) | 22 (26.8%) | 69 (53.5%) | V=0.71 (p<0.001) |
Leiomiosarcom | 0 | 29 (35.4%) | 29 (22.5%) | ||
Sarcom stromal endometrial | 0 | 31 (37.8%) | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 43 (22:65) | 48 (22:82) | 44 (22:82) | MW: p=0.030 |
Mean ±SD | 43.02 ±8.52 | 49.74 ±15.2 | 47.29 ±13.5 | ||
Malignitate | malign | 0 | 60 (73.2%) | 60 (46.5%) | OR=0.00 [0.00, 0.07], RR=0.00 [0.00, 0.00] (p<0.001) |
benign | 47 (100.0%) | 22 (26.8%) | 69 (53.5%) | ||
Hemoragii | 12 (25.5%) | 64 (78.0%) | 76 (58.9%) | OR=0.10 [0.04, 0.22], RR=0.33 [0.20, 0.53] (p<0.001) | |
Necroză | 11 (23.4%) | 64 (78.0%) | 75 (58.1%) | OR=0.09 [0.04, 0.20], RR=0.30 [0.18, 0.50] (p<0.001) | |
Atipii | 1 (2.1%) | 60 (73.2%) | 61 (47.3%) | OR=0.01 [0.00, 0.06], RR=0.03 [0.01, 0.14] (p<0.001) | |
Metoda de detecție | histerectomie | 30 (63.8%) | 70 (85.4%) | 100 (77.5%) | V=0.25 (p=0.018) |
histeroscopie | 5 (10.6%) | 3 (3.7%) | 8 (6.2%) | ||
miomectomie | 12 (25.5%) | 9 (11.0%) | 21 (16.3%) | ||
Județ | AB | 2 (4.3%) | 2 (2.4%) | 4 (3.1%) | V=0.36 (p=0.623) |
BC | 0 | 1 (1.2%) | 1 (0.8%) | ||
BH | 3 (6.4%) | 3 (3.7%) | 6 (4.7%) | ||
BN | 3 (6.4%) | 7 (8.5%) | 10 (7.8%) | ||
BT | 0 | 1 (1.2%) | 1 (0.8%) | ||
BV | 0 | 2 (2.4%) | 2 (1.6%) | ||
CJ | 24 (51.1%) | 39 (47.6%) | 63 (48.8%) | ||
GJ | 1 (2.1%) | 2 (2.4%) | 3 (2.3%) | ||
GL | 0 | 1 (1.2%) | 1 (0.8%) | ||
HD | 2 (4.3%) | 4 (4.9%) | 6 (4.7%) | ||
MH | 1 (2.1%) | 0 | 1 (0.8%) | ||
MM | 4 (8.5%) | 3 (3.7%) | 7 (5.4%) | ||
MS | 2 (4.3%) | 0 | 2 (1.6%) | ||
NT | 1 (2.1%) | 1 (1.2%) | 2 (1.6%) | ||
SB | 1 (2.1%) | 0 | 1 (0.8%) | ||
SJ | 1 (2.1%) | 6 (7.3%) | 7 (5.4%) | ||
SM | 1 (2.1%) | 6 (7.3%) | 7 (5.4%) | ||
SV | 1 (2.1%) | 2 (2.4%) | 3 (2.3%) | ||
TM | 0 | 1 (1.2%) | 1 (0.8%) | ||
VL | 0 | 1 (1.2%) | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 4 (0.5:12.5) | 9 (2:29) | 6 (0.5:29) | MW: p<0.001 |
Mean ±SD | 4.73 ±2.55 | 9.95 ±5.57 | 7.44 ±5.1 | ||
Localizare | intramural | 36 (76.6%) | 45 (54.9%) | 81 (62.8%) | V=0.47 (p<0.001) |
corp uterin | 0 | 30 (36.6%) | 30 (23.3%) | ||
submucos | 4 (8.5%) | 6 (7.3%) | 10 (7.8%) | ||
subseros | 7 (14.9%) | 1 (1.2%) | 8 (6.2%) | ||
Markeri imunohistochimici | 4 (8.5%) | 29 (35.4%) | 33 (25.6%) | OR=0.17 [0.06, 0.52], RR=0.24 [0.10, 0.61] (p<0.001) | |
CD10 | 0 | 1 (3.4%) | 1 (3.0%) | OR=2.11 [0.07, 60.26], RR=0.00 [0.00, 0.00] (p=1.000) | |
p53 | 0 | 1 (3.4%) | 1 (3.0%) | OR=2.11 [0.07, 60.26], RR=0.00 [0.00, 0.00] (p=1.000) | |
Ki 67 | 3 (75.0%) | 5 (17.2%) | 8 (24.2%) | OR=14.40 [1.23, 168.50], RR=4.35 [1.88, 10.06] (p=0.036) | |
CK AE1/AE3 | 1 (25.0%) | 1 (3.4%) | 2 (6.1%) | OR=9.33 [0.46, 190.63], RR=7.25 [0.97, 53.96] (p=0.231) | |
SMA | 0 | 3 (10.3%) | 3 (9.1%) | OR=0.84 [0.04, 19.19], RR=0.00 [0.00, 0.00] (p=1.000) | |
RE, RP | 2 (50.0%) | 0 | 2 (6.1%) | OR=59.00 [2.18, 1 598.75], RR=Inf [Inf, Inf] (p=0.011) | |
CEA | 1 (25.0%) | 0 | 1 (3.0%) | OR=25.29 [0.85, 747.87], RR=Inf [Inf, Inf] (p=0.121) | |
CA125 | 1 (25.0%) | 0 | 1 (3.0%) | OR=25.29 [0.85, 747.87], RR=Inf [Inf, Inf] (p=0.121) | |
S100, HMB45, Actina | 1 (25.0%) | 0 | 1 (3.0%) | OR=25.29 [0.85, 747.87], RR=Inf [Inf, Inf] (p=0.121) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
Tabel 17: All vs.Markeri imunohistochimici
Factor | Levels | da | nu | Total | Statistics |
Markeri imunohistochimici | 33 (25.6%) | 96 (74.4%) | 129 | ||
Diagnostic | Leiomiom | 5 (15.2%) | 64 (66.7%) | 69 (53.5%) | V=0.67 (p<0.001) |
Leiomiosarcom | 4 (12.1%) | 25 (26.0%) | 29 (22.5%) | ||
Sarcom stromal endometrial | 24 (72.7%) | 7 (7.3%) | 31 (24.0%) | ||
Vârsta (ani) | *M(R) | 50 (29:79) | 44 (22:82) | 44 (22:82) | MW: p=0.164 |
Mean ±SD | 50.21 ±14.2 | 46.29 ±13.2 | 47.29 ±13.5 | ||
Malignitate | malign | 28 (84.8%) | 32 (33.3%) | 60 (46.5%) | OR=11.20 [3.95, 31.75], RR=2.55 [1.87, 3.47] (p<0.001) |
benign | 5 (15.2%) | 64 (66.7%) | 69 (53.5%) | ||
Hemoragii | 29 (87.9%) | 47 (49.0%) | 76 (58.9%) | OR=7.56 [2.47, 23.15], RR=1.79 [1.42, 2.27] (p<0.001) | |
Necroză | 28 (84.8%) | 47 (49.0%) | 75 (58.1%) | OR=5.84 [2.08, 16.39], RR=1.73 [1.36, 2.21] (p<0.001) | |
Atipii | 28 (84.8%) | 33 (34.4%) | 61 (47.3%) | OR=10.69 [3.78, 30.27], RR=2.47 [1.82, 3.35] (p<0.001) | |
Metoda de detecție | histerectomie | 30 (90.9%) | 70 (72.9%) | 100 (77.5%) | V=0.20 (p=0.075) |
histeroscopie | 0 | 8 (8.3%) | 8 (6.2%) | ||
miomectomie | 3 (9.1%) | 18 (18.8%) | 21 (16.3%) | ||
Județ | AB | 0 | 4 (4.2%) | 4 (3.1%) | V=0.38 (p=0.478) |
BC | 0 | 1 (1.0%) | 1 (0.8%) | ||
BH | 1 (3.0%) | 5 (5.2%) | 6 (4.7%) | ||
BN | 2 (6.1%) | 8 (8.3%) | 10 (7.8%) | ||
BT | 0 | 1 (1.0%) | 1 (0.8%) | ||
BV | 0 | 2 (2.1%) | 2 (1.6%) | ||
CJ | 18 (54.5%) | 45 (46.9%) | 63 (48.8%) | ||
GJ | 1 (3.0%) | 2 (2.1%) | 3 (2.3%) | ||
GL | 1 (3.0%) | 0 | 1 (0.8%) | ||
HD | 2 (6.1%) | 4 (4.2%) | 6 (4.7%) | ||
MH | 0 | 1 (1.0%) | 1 (0.8%) | ||
MM | 2 (6.1%) | 5 (5.2%) | 7 (5.4%) | ||
MS | 0 | 2 (2.1%) | 2 (1.6%) | ||
NT | 0 | 2 (2.1%) | 2 (1.6%) | ||
SB | 0 | 1 (1.0%) | 1 (0.8%) | ||
SJ | 2 (6.1%) | 5 (5.2%) | 7 (5.4%) | ||
SM | 1 (3.0%) | 6 (6.2%) | 7 (5.4%) | ||
SV | 3 (9.1%) | 0 | 3 (2.3%) | ||
TM | 0 | 1 (1.0%) | 1 (0.8%) | ||
VL | 0 | 1 (1.0%) | 1 (0.8%) | ||
Dimensiune (cm) | *M(R) | 10 (3:29) | 6 (0.5:21) | 6 (0.5:29) | MW: p=0.179 |
Mean ±SD | 11.56 ±8.78 | 7.03 ±4.44 | 7.44 ±5.1 | ||
Localizare | intramural | 7 (21.2%) | 74 (77.1%) | 81 (62.8%) | V=0.65 (p<0.001) |
corp uterin | 23 (69.7%) | 7 (7.3%) | 30 (23.3%) | ||
submucos | 1 (3.0%) | 9 (9.4%) | 10 (7.8%) | ||
subseros | 2 (6.1%) | 6 (6.2%) | 8 (6.2%) | ||
Mutiple/unice | multiple | 4 (12.1%) | 43 (44.8%) | 47 (36.4%) | OR=0.17 [0.06, 0.52], RR=0.27 [0.11, 0.66] (p<0.001) |
unice | 29 (87.9%) | 53 (55.2%) | 82 (63.6%) | ||
CD10 | 1 (3.0%) | 0 | 1 (3.0%) | OR=0.05 [0.00, 3.23] (p=1.000) | |
p53 | 1 (3.0%) | 0 | 1 (3.0%) | OR=0.05 [0.00, 3.23] (p=1.000) | |
Ki 67 | 8 (24.2%) | 0 | 8 (24.2%) | OR=0.33 [0.01, 18.13] (p=1.000) | |
CK AE1/AE3 | 2 (6.1%) | 0 | 2 (6.1%) | OR=0.08 [0.00, 4.92] (p=1.000) | |
SMA | 3 (9.1%) | 0 | 3 (9.1%) | OR=0.11 [0.00, 6.74] (p=1.000) | |
RE, RP | 2 (6.1%) | 0 | 2 (6.1%) | OR=0.08 [0.00, 4.92] (p=1.000) | |
CEA | 1 (3.0%) | 0 | 1 (3.0%) | OR=0.05 [0.00, 3.23] (p=1.000) | |
CA125 | 1 (3.0%) | 0 | 1 (3.0%) | OR=0.05 [0.00, 3.23] (p=1.000) | |
S100, HMB45, Actina | 1 (3.0%) | 0 | 1 (3.0%) | OR=0.05 [0.00, 3.23] (p=1.000) | |
*M(R) = Mediana (min:max); MW = Test Mann-Whitney; OR/RR = odds-ratio / risc relativ [cu IC 95%] și p calculat prin testul Fisher); V = Cramer V (p calculat prin testul Chi²). | |||||
$`1950s kitchen`
[1] "#b3dbc0" "#fe0000" "#fdf6f6" "#67baca"
$`Antique and clean`
[1] "#b56357" "#b4dbc0" "#eae3ea" "#a7b3a5"
$`Antique tones`
[1] "#155765" "#57652a" "#ab9353" "#4d2c3d"
$`Aqua blues`
[1] "#004d47" "#128277" "#52958b" "#b9c4c9"
$`Art history inspired`
[1] "#ffce00" "#0375b4" "#007849" "#262228"
$`Artic sunrise`
[1] "#ffccbb" "#6eb5c0" "#006c84" "#e2e8e4"
$`Autumn in vermont`
[1] "#8d230f" "#1e434c" "#9b4f0f" "#c99e10"
$`Autumn oranges and complemtentary neutrals`
[1] "#d55448" "#ffa577" "#f9f9ff" "#896e69"
$`Back to school`
[1] "#81715e" "#faae3d" "#e38533" "#e4535e"
$`Berry blues`
[1] "#1e1f26" "#283655" "#4d648d" "#d0e1f9"
$`Beyond black and white`
[1] "#31a2ac" "#af1c1c" "#f0eff0" "#2f2f28"
$`Birds and berries`
[1] "#9a9eab" "#5d535e" "#ec96a4" "#dfe166"
$`Bold and basic`
[1] "#000b29" "#d70026" "#f8f5f2" "#edb83d"
$`Bold and cultured`
[1] "#4c3f54" "#d13525" "#f2c057" "#486824"
$`Bold and punchy`
[1] "#e24e42" "#e9b000" "#eb6e80" "#008f95"
$`Bold berries`
[1] "#50312f" "#cb0000" "#e4ea8c" "#3f6c45"
$`Bold blacks and vibrand highlights`
[1] "#000000" "#ec576b" "#4ec5c1" "#e5e338"
$`Bold feature colors`
[1] "#e14658" "#22252c" "#3f3250" "#c0b3a0"
$`Bright and painterly`
[1] "#061283" "#fd3c3c" "#ffb74c" "#138d90"
$`Bright and tropical`
[1] "#f52549" "#fa6775" "#ffd64d" "#9bc01c"
$`Candy coated brights`
[1] "#f47d4a" "#e1315b" "#ffec5c" "#008dcb"
$`Cheerful and friendly`
[1] "#2b616d" "#b2dbd5" "#ffffff" "#fa8d62"
$`Cheerful and sleek`
[1] "#6b7a8f" "#f7882f" "#f7c331" "#dcc7aa"
$`Cheerful blues and pink`
[1] "#ffbebd" "#fcfcfa" "#337bae" "#1a405f"
$`Cheerful brights`
[1] "#258039" "#f5be41" "#31a9b8" "#cf3721"
$`Chocolaty browns`
[1] "#301b28" "#523634" "#b6452c" "#ddc5a2"
$`City sights`
[1] "#c5001a" "#e4e3db" "#113743" "#c5beba"
$`Classic metallics`
[1] "#080706" "#efefef" "#d1b280" "#594d46"
$`Classy and timeless`
[1] "#16253d" "#002c54" "#efb509" "#cd7213"
$`Clean and collegiate`
[1] "#4abdac" "#99ced4" "#eeb6b7" "#6e7376"
$`Clean and crisp`
[1] "#99d3df" "#88bbd6" "#cdcdcd" "#e9e9e9"
$`Clean and highlighted`
[1] "#caebf2" "#a9a9a9" "#ff3b3f" "#efefef"
$`Clean gradient and fresh blues`
[1] "#77c9d4" "#57bc90" "#015249" "#a5a5af"
$Coastal
[1] "#a5c3cf" "#f3d3b8" "#e59d5c" "#a99f3c"
$`Colorful without clashing`
[1] "#fa7c92" "#6ec4d8" "#fff7c0" "#66ab8c"
$`Cool and calm`
[1] "#6bbaa7" "#fba100" "#6c648b" "#b6a19e"
$`Cool blues`
[1] "#003b46" "#07575b" "#66a5ad" "#c4dfe6"
$`Cool jewel tones`
[1] "#67aeca" "#675682" "#5f0f4e" "#e52a6f"
$`Cool vs warm`
[1] "#18121e" "#233237" "#984b43" "#eac67a"
$`Corporate and sleek`
[1] "#f7f5e6" "#333a56" "#52658f" "#e8e8e8"
$Cosmopolitan
[1] "#8593ae" "#5a4e4d" "#7e675e" "#dda288"
$`Cozy and warm`
[1] "#662225" "#b51d0a" "#ead39c" "#7d5e3c"
$`Crisp and dramatic`
[1] "#505160" "#68829e" "#aebd38" "#598234"
$`Crisp complementary colors`
[1] "#f4ec6a" "#bbcf4a" "#e73f0b" "#a11f0c"
$`Dark and earthy`
[1] "#46211a" "#693d3d" "#ba5536" "#a43820"
$`Dark and handsome`
[1] "#42313a" "#6c2d2c" "#9f4636" "#f1dcc9"
$`Day and night`
[1] "#011a27" "#063852" "#f0810f" "#e6df44"
$`Distintive and unexpected`
[1] "#52908b" "#e5e2ca" "#ddbc95" "#e7472e"
$`Earthy and fresh`
[1] "#945d60" "#626e60" "#af473c" "#3c3c3c"
$`Elegant and sophisticated`
[1] "#0b83c5" "#328cc1" "#d9b310" "#1d2731"
$`Exotic and high impact`
[1] "#0f1f38" "#8e7970" "#f55449" "#1b4b5a"
$`Fresh and bright`
[1] "#f98866" "#ff420e" "#80bd9e" "#89da59"
$`Fresh and energetic`
[1] "#4cb5f5" "#b7b8b6" "#34675c" "#b3c100"
$`Fresh and lively`
[1] "#4cdef5" "#a4d555" "#ff5992" "#841983"
$`Fresh greens`
[1] "#265c00" "#68a225" "#b3de81" "#fdffff"
$`Fun and cheerful`
[1] "#a7d2cb" "#f2d388" "#c98474" "#874c62"
$`Fun and professional`
[1] "#4abdac" "#fc4a1a" "#f7b733" "#dfdce3"
$`Fun and tropical`
[1] "#4897d8" "#ffdb5c" "#fa6e59" "#f8a055"
$`Garden fresh`
[1] "#ee693f" "#f69454" "#fcfdfe" "#739f3d"
$`Golden afternoon`
[1] "#882426" "#cdbea7" "#323030" "#c29545"
$`Grecian holiday`
[1] "#2988bc" "#2f496e" "#f4eade" "#ed8c72"
$`Green fields`
[1] "#919636" "#524a3a" "#fffae1" "#5a5f37"
$`Hazy grays`
[1] "#2c4a52" "#537072" "#8e9b97" "#f4ebdb"
$`High saturation and high energy`
[1] "#fe65b7" "#e9c904" "#8fc33a" "#62edd6"
$`Icy blues and grays`
[1] "#f1f1f2" "#bcbabe" "#a1d6e2" "#1995ad"
$`Industrial and in control`
[1] "#20232a" "#acbebe" "#f4f4ef" "#a01d26"
$`Jewel tones`
[1] "#7f152e" "#d61800" "#edae01" "#e94f08"
$`Lemonade stand`
[1] "#f70025" "#f7efe2" "#f25c00" "#f9a603"
$`Light and natural`
[1] "#688b8a" "#a0b084" "#faefd4" "#a57c65"
$`Luxurious and modern`
[1] "#0f1626" "#ab987a" "#ff533d" "#f5f5f5"
$`Maritime brights`
[1] "#257985" "#5ea8a7" "#ffffff" "#ff4447"
$`Mediterranean afternoon`
[1] "#8c0004" "#c8000a" "#e8a735" "#e2c499"
$`Misty greens`
[1] "#04202c" "#304040" "#5b7065" "#c9d1c8"
$`Modern and clean`
[1] "#e37222" "#07889b" "#66b9bf" "#eeaa7b"
$`Modern and crisp`
[1] "#0f1b07" "#ffffff" "#5c821a" "#c6d166"
$`Modern and minimal`
[1] "#c06014" "#eddbc0" "#000000" "#cdcdcd"
$`Modern and muted`
[1] "#a9b7c0" "#c7d8c6" "#efd9c1" "#cccbc6"
$`Modern and urban`
[1] "#f9ba32" "#426e86" "#f8f1e5" "#2f3131"
$`Muted and antique`
[1] "#a4cabc" "#eab364" "#b2473e" "#acbd78"
$`Muted and minimal`
[1] "#96858f" "#6d7993" "#9099a2" "#d5d5d5"
$`Muted tones`
[1] "#c0b283" "#dcd0c0" "#f4f4f4" "#373737"
$`Naturally elegant`
[1] "#ebdf00" "#7e7b15" "#563e20" "#b38540"
$`Neon and bold`
[1] "#d48cf8" "#0e8044" "#b5e582" "#08302f"
$`Neon night`
[1] "#f77604" "#b8d20b" "#f56c57" "#231b12"
$`Neon tones and sharp contrast`
[1] "#0e0b16" "#a239ca" "#4717f6" "#e7dfdd"
$`Neutral and versatile`
[1] "#626d71" "#cdcdc0" "#ddbc95" "#b38867"
$Nightlife
[1] "#00cffa" "#ff0038" "#ffce38" "#020509"
$`Orange accent`
[1] "#756867" "#dad9d3" "#353c3f" "#ff8d3f"
$`Outdoorsy and Natural`
[1] "#2e4600" "#486b00" "#a2c523" "#7d4427"
$Pastels
[1] "#c1e1dc" "#ffccac" "#ffeb94" "#fdd475"
$`Playful greens and blues`
[1] "#324851" "#86ac41" "#34675c" "#7da3a1"
$`Polished and inviting`
[1] "#eae2d6" "#d5c3aa" "#867666" "#e1b80d"
$`Pool party`
[1] "#344d90" "#5cc5ef" "#ffb745" "#e7552c"
$`Pop art`
[1] "#d7dd35" "#575da9" "#e42d9f" "#02558b"
$`Pretty pastels`
[1] "#bfd8d2" "#fedcd2" "#df744a" "#dcb239"
$`Primary colors with a vibrant twist`
[1] "#375e97" "#fb6542" "#ffbb00" "#3f681c"
$`Professional and modern`
[1] "#c5c1c0" "#0a1612" "#1a2930" "#f7ce3e"
$`Professional and traditional`
[1] "#962715" "#ffffff" "#1e1e20" "#bbc3c6"
$`Refreshing and pretty`
[1] "#98dbc6" "#5bc8ac" "#e6d72a" "#f18d9e"
$`Retro and relaxing`
[1] "#d35c37" "#bf9a77" "#d6c6b9" "#97b8c2"
$`Retro inspired`
[1] "#fedc3d" "#000000" "#01abaa" "#fea680"
$`Serene and spa like`
[1] "#a1be95" "#e2dfa2" "#92aac7" "#ed5752"
$`Shabby chic neutrals`
[1] "#6c5f5b" "#cdab81" "#dac3b3" "#4f4a45"
$`Shades of citrus`
[1] "#eb8a44" "#f9dc24" "#4b7447" "#8eba43"
$`Shadowy and dramatic`
[1] "#262f34" "#f34a4a" "#f1d3bc" "#615049"
$`Sharp and modern`
[1] "#3cc47c" "#1e392a" "#e9c893" "#828081"
$`Simple and fresh`
[1] "#414141" "#ccdfcb" "#ff6a5c" "#056571"
$`Simple but bold`
[1] "#f7ef6a" "#93c178" "#465c8b" "#dfdce3"
$`Sleek and modern`
[1] "#2f2e33" "#d5d6d2" "#ffffff" "#3a5199"
$`Smoky purples`
[1] "#a49592" "#727077" "#eed8c9" "#e99787"
$`Spicy neutrals`
[1] "#af4425" "#662e1c" "#ebdcb2" "#c9a66b"
$`Splash of color`
[1] "#4484ce" "#d9d9d9" "#f9cf00" "#f19f4d"
$`Stormy hues`
[1] "#494e6b" "#98878f" "#985e6d" "#192231"
$`Strawberries and cream`
[1] "#d8412f" "#fe7a47" "#fcfdfe" "#f5ca99"
$`Striking and energetic`
[1] "#f81b84" "#f5ce28" "#43c0f6" "#f2eee2"
$`Stylish and retro`
[1] "#75b1a9" "#d9b44a" "#4f6457" "#acd0c0"
$`Subdued and proffesional`
[1] "#90afc5" "#336b87" "#2a3132" "#763626"
$`Subtle and versatile`
[1] "#5f968e" "#bfdccf" "#e05858" "#d5c9b1"
$`Summer barbeque`
[1] "#b9d9c3" "#752a07" "#fbcb7b" "#eb5e30"
$`Summer fiesta`
[1] "#c7db00" "#7aa802" "#f78b2d" "#e4b600"
$`Summer inspired`
[1] "#286da8" "#cd5360" "#b37d4e" "#438496"
$`Summer sunflower`
[1] "#34888c" "#7caa2d" "#f5e356" "#cb6318"
$`Sun and sky`
[1] "#217ca3" "#e29930" "#32384d" "#211f30"
$`Sunkissed village`
[1] "#d24136" "#eb8a3e" "#ebb582" "#785a46"
$`Sunny and calm`
[1] "#cae4db" "#dcae1d" "#00303f" "#7a9d96"
$`Sunny citrus`
[1] "#faaf08" "#fa812f" "#fa4032" "#fef3e2"
$`Sunset to dusk`
[1] "#363237" "#2d4262" "#73605b" "#d09683"
$`Surf and turf`
[1] "#f4cc70" "#de7a22" "#20948b" "#6ab187"
$`Technology meets nature`
[1] "#fbcd4b" "#a3a599" "#282623" "#88a550"
$`Timeless and nautical`
[1] "#00293c" "#1e656d" "#f1f3ce" "#f62a00"
$`Tints and tones`
[1] "#94618e" "#49274a" "#f4decb" "#f8eee7"
$`Trendy and metropolitan`
[1] "#488a99" "#dbae58" "#fbe9e7" "#b4b4b4"
$`Tropical tones`
[1] "#1fb58f" "#eab126" "#f24c4e" "#1b7b34"
$`Understated and versatile`
[1] "#335252" "#d4dde1" "#aa4b41" "#2d3033"
$`Unexpected color combinations`
[1] "#6e3667" "#88d317" "#1a0315" "#535353"
$`Unique and striking`
[1] "#cf6766" "#30415d" "#031424" "#8eaebd"
$`Urban living`
[1] "#dddede" "#232122" "#a5c05b" "#7ba4a8"
$`Urban oasis`
[1] "#506d2f" "#2a2922" "#f3ebdd" "#7d5642"
$`Vineyard neutrals`
[1] "#1e0000" "#500805" "#9d331f" "#bc6d4f"
$`Vintage charm`
[1] "#fcc875" "#baa896" "#e6ccb5" "#e38b75"
$`Vintage charm 2`
[1] "#cda34f" "#e9e7da" "#636b46" "#373f27"
$`Violet sunset`
[1] "#4b4345" "#556dac" "#f79b77" "#755248"
$`Warm and bold`
[1] "#000000" "#062f4f" "#813772" "#b82601"
$`Warm and cool`
[1] "#444c5c" "#ce5a57" "#78a5a3" "#e1b16a"
$`Warm and rustic`
[1] "#fef2e4" "#fd974f" "#c60000" "#805a3b"
$`Warm and wonderful`
[1] "#7cd8d5" "#f53240" "#f9be02" "#02c8a7"
$`Warm naturals`
[1] "#2e2300" "#6e6702" "#c05805" "#db9501"
$`Warm tones`
[1] "#d7cec7" "#565656" "#76323f" "#c09f80"
$`Watery blue-greens`
[1] "#021c1e" "#004445" "#2c7873" "#6fb98f"
$`Wintery reds`
[1] "#a10115" "#d72c16" "#f0efea" "#c0b2b5"