Last update: Sat May 11 21:55:34 2019

Baseline patients characteristics and breaths classification

variables Pes Raters
Vt (ml/kg) 6.19 (5.86-6.48) 6.06 (5.88-6.53)
RR (bpm) 27 (25.5-29) 26 (23-30)
PEEP (cmH2O) 12.1 (9.5-13) 13 (10-16)
Pplat (cmH2O) 23 (18.75-23.5) 25 (22-27.6)
pH 7.36 (7.34-7.4) 7.35 (7.3-7.41)
PaO2/FiO2 (mmHg) 212.5 (156.87-263.33) 183.51 (146.67-230)
RASS -5 (-5–4) -5 (-5–4)
Normal 308 (43.38%) 1420 (84.83%)
IE 262 (36.9%) 201 (12.01%)
RT 135 (19.01%) 51 (3.05%)
DT 5 (0.7%) 2 (0.12%)

Performance compared with Pes

## Confusion Matrix and Statistics
## 
##           Reference
## Prediction  DT  IE Normal  RT
##     DT       5   0      0  12
##     IE       0 227     13   0
##     Normal   0  35    295   2
##     RT       0   0      0 121
## 
## Overall Statistics
##                                           
##                Accuracy : 0.9127          
##                  95% CI : (0.8895, 0.9324)
##     No Information Rate : 0.4338          
##     P-Value [Acc > NIR] : < 2.2e-16       
##                                           
##                   Kappa : 0.8635          
##  Mcnemar's Test P-Value : NA              
## 
## Statistics by Class:
## 
##                      Class: DT Class: IE Class: Normal Class: RT
## Sensitivity           1.000000    0.8664        0.9578    0.8963
## Specificity           0.982979    0.9710        0.9080    1.0000
## Pos Pred Value        0.294118    0.9458        0.8886    1.0000
## Neg Pred Value        1.000000    0.9255        0.9656    0.9762
## Prevalence            0.007042    0.3690        0.4338    0.1901
## Detection Rate        0.007042    0.3197        0.4155    0.1704
## Detection Prevalence  0.023944    0.3380        0.4676    0.1704
## Balanced Accuracy     0.991489    0.9187        0.9329    0.9481

Agreement between raters

Between raters complete agreement in breaths classification was observed in 72.88%.

RaterVote agreement
Normal 100 (100-100)
RT 100 (20-100)
IE 85.71 (80-100)
DT 55.71 (47.86-63.57)

Performance compared with raters vote

## Confusion Matrix and Statistics
## 
##           Reference
## Prediction   DT   IE Normal   RT
##     DT        0    0      0    4
##     IE        0  153      9    0
##     Normal    0   47   1411    2
##     RT        2    1      0   45
## 
## Overall Statistics
##                                           
##                Accuracy : 0.9612          
##                  95% CI : (0.9508, 0.9699)
##     No Information Rate : 0.8483          
##     P-Value [Acc > NIR] : < 2.2e-16       
##                                           
##                   Kappa : 0.8432          
##  Mcnemar's Test P-Value : NA              
## 
## Statistics by Class:
## 
##                      Class: DT Class: IE Class: Normal Class: RT
## Sensitivity           0.000000   0.76119        0.9937   0.88235
## Specificity           0.997608   0.99389        0.8071   0.99815
## Pos Pred Value        0.000000   0.94444        0.9664   0.93750
## Neg Pred Value        0.998802   0.96825        0.9579   0.99631
## Prevalence            0.001195   0.12007        0.8483   0.03047
## Detection Rate        0.000000   0.09140        0.8429   0.02688
## Detection Prevalence  0.002389   0.09677        0.8722   0.02867
## Balanced Accuracy     0.498804   0.87754        0.9004   0.94025

Results

Data from 11 patient including 710 breaths with esophageal pressure signal was used for the first evaluation. Clinical data from these patients is included in table 1.
Randomly selected breaths from 99 patients with ARDS were evaluated by 7 differente experts.