ISP analysis

Data description

Table 1. Charasteristics of patients at admission in rehab centers

var	Overall	Missing
n	152
age_event (mean (SD))	52.3 (18.0)	0.0
sex = M (%)	95 (62.5)	0.0
days_icu (mean (SD))	45.4 (20.1)	0.0
etiology (%)		0.0
TBI	54 (35.5)
Vascular	77 (50.7)
Anoxic	15 (9.9)
Infective	2 (1.3)
Neoplastic	4 (2.6)
Mixed	0 (0.0)
isp_icu = yes (%)	15 (11.2)	11.8
treatment (%)		0.0
none	18 (8.1)
opioids	10 (4.5)
benzos	23 (10.4)
barbiturate	6 (2.7)
beta_blockers	70 (31.7)
alpha_blockers	16 (7.2)
dopa_antagonist	3 (1.4)
baclofen	18 (8.1)
other	57 (25.8)

Table 2. Charasteristics of patients in the first week of rehab (T0)

var	Overall	Missing
n	152
diagnosis (%)		0.0
Emersion	39 (25.7)
MCS	54 (35.5)
VS	59 (38.8)
crs_r (mean (SD))	11.9 (7.1)	0.7
lcf (mean (SD))	3.1 (1.3)	0.0
tracheo = yes (%)	135 (88.8)	0.0
breath (%)		5.9
Autonomous	58 (40.6)
Autonomous + O2	80 (55.9)
Mechanical	5 (3.5)
feed (%)		0.7
Oral	11 (7.3)
Parenteral	2 (1.3)
NG-tube	63 (41.7)
PEG	75 (49.7)
cateth = yes (%)	147 (96.7)	0.0
bedsore = yes (%)	55 (36.2)	0.0
fractures = yes (%)	37 (24.3)	0.0
asworth = yes (%)	31 (20.4)	0.0
poa = yes (%)	4 (2.6)	0.0
craniolac = yes (%)	32 (21.1)	0.0
hydrocef = yes (%)	15 (9.9)	0.0
erbi_sub_a (mean (SD))	-177.8 (42.1)	0.0
erbi_sub_b (mean (SD))	0.7 (5.4)	0.0
psh_cfs_t0 (mean (SD))	3.4 (2.9)	5.9
psh_dlt_t0 (mean (SD))	2.7 (2.4)	5.9
psh_tot_t0 (mean (SD))	6.8 (5.8)	0.0
psh_tot_t0_cat (%)		0.7
Unlikely	104 (68.9)
Possible	31 (20.5)
Probable	16 (10.6)
nr_crisis_t0 (%)		6.6
none	112 (78.9)
<3	15 (10.6)
3-5	14 (9.9)
>5	1 (0.7)
treatment (%)		0.0
none	91 (55.8)
opioids	5 (3.1)
benzos	19 (11.7)
barbiturate	0 (0.0)
beta_blockers	25 (15.3)
alpha_blockers	7 (4.3)
dopa_antagonist	0 (0.0)
baclofen	7 (4.3)
other	9 (5.5)

Table 3. Charasteristics of patients in the second week of rehab (T1)

var	Overall	Missing
n	152
psh_cfs_t1 (mean (SD))	2.9 (2.4)	5.9
psh_dlt_t1 (mean (SD))	2.5 (2.3)	5.9
psh_tot_t1 (mean (SD))	6.1 (5.3)	0.0
psh_tot_t1_cat (%)		0.0
Unlikely	115 (75.7)
Possible	24 (15.8)
Probable	13 (8.6)
nr_crisis_t1 (%)		5.9
none	122 (85.3)
<3	13 (9.1)
3-5	8 (5.6)
>5	0 (0.0)
treatment (%)		0.0
none	92 (56.4)
opioids	4 (2.5)
benzos	18 (11.0)
barbiturate	0 (0.0)
beta_blockers	25 (15.3)
alpha_blockers	6 (3.7)
dopa_antagonist	0 (0.0)
baclofen	7 (4.3)
other	11 (6.7)

Descriptive Plots (Captions are below the figures)

There is no association between the age of patient at event and days in ICU

Figure 1. ICU lenght of stay by patient’s age

Figure 2. Registered treatments per week

Figure 3. Registered treatments at admission by reported ISP crisis in ICU

Figure 4. Registered treatments at week1 and 2 by reported nr. of ISP crisis

Figure 5. CRS-R (A) and LCF (B) by diagnosis

Figure 6. Number of Patients on tracheostomy (A) and assisted ventilation (B) by diagnosis

Figure 7. Number of Patients on assisted feeding (A) and urinary catheterization (B) by diagnosis

Figure 8. Number of Patients with bedsore (A), spasticity (measured by Asworth scale; C), fractures (B) and POA (D) by diagnosis

Figure 8. Number of Patients with Luckenschadel (A) and Hydrocefalus (B) by diagnosis

Figure 9. ERBI subscale A (A) and ERBI subscale B (B) by diagnosis

Figure 10. PSH-AM scale result by nr. of ISP crisis in the first week of rehab

Figure 11. PSH-AM total score by nr. of ISP crisis and treatment in the first week of rehab (numbers indicate subgroup size)