Nested Interaction to detect how GFR responds differently than GF

Pipeline overview

This script uses nested interaction formulas to: 1. characterize consistent differences between GF and GFR strains, regardless of treatment. 2. characterize consistent differences between treated and untreated samples, regardless of strain.
3. execute a 2X2 factorial analysis of the data set to identify how GFR responds differently to treatment than GF.

This pipeline is adapted from https://bioconductor.org/packages/devel/workflows/vignettes/maEndToEnd/inst/doc/MA-Workflow.html (this required a good deal of modification to current pipeline)

Brief summary of pair-wise test results

To this point, the pairwise tests have yielded somewhat inconsistent results, although some generalizations can be made (this pipeline aims to improve upon these)

1. The GF tests were apparently much more consistent, yielding many more significant but not necessarily large DE genes.

2. One of the strongest up-regulated genes upon exposure in both GF and GFR was SYTL2 (Synaptotagmin Like 2), upregulated by 2^2, or 4-fold in both strains. While this protein does not formally map to any pathways in reactome system, Reactome does flag it as interacting with “Response to Protein Unfolding” systems. GO links it directly to “Regulation of Catalytic Activity” and “Regulation of Secretion” systems (GO:0043086, GO:0051046). According to the Entrez gene description https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=54843 “The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A).”

3. SESN3 is upregulated 2^2.5, or ~6-fold in GF following treatment. https://www.genecards.org/cgi-bin/carddisp.pl?gene=SESN3. This is a stress-induced protein, responds to intracellular reactive oxygen species. In GFR, this gene was upregulated by only 2^1.43, beneath significance thresholds, although notably, the average expression was actually higher. This is indeed confirmed by comparing cGFR to cGF: average expression in the mutant was 2^0.74, 1.65-fold, higher

4. In GFR and GF, a single fatty-acid synthesis gene, EVLOVL, was upregulated by 2^1.6 (3-fold) and 4-fold, respectively, by drug exposure. Could this be involved in replacing damaged lipids?

5. Initial inspection of the treated GFR vs treated GF DE genes suggests dramatic results, although they are similar in scale to the untreated GFR vs GF results. Scanning of these genes suggests a wide variety of especially immune/inflammation genes and genes linked to the Ras system, and genes involved in adhesion. It is not clear upon first inspection whether GFR really responded any differently to GF to the treatment. In this pipeline I will attempt to focus on this main aspect of the project.

Preparation

The Annotation and probe.gene.map R objects should be written by previous R scripts.

Results files;

A. General data preparation

1. Prepare the base environment

2. Prepare Annotation Table to yield useful mappings of probe to gene

Annotation <- read.csv("HTA-2_0.na35.2.hg19.transcript.csv/HTA-2_0.na35.2.hg19.transcript.csv", header=TRUE, skip=19)
probe.gene.map <- read.csv("probe.gene.map.csv")

3. Set up “Targets” object

“Targets” is essentially a metadata set. This is used to configure tests (ex. GF vs)

targets <- read.csv("targets.txt", as.is=T)
Experiment <- factor(targets$Experiment)
Strain <- factor(targets$Strain, levels=c("GF","GFR"))
Treatment <- factor(targets$Treatment, levels=c("control","drug"))

all of the samples and metadata are listed here:

targets 

##                                      FileName Strain Treatment Experiment
## 1   20160505_HTA2.0_0316_WTH_1R_(HTA-2_0).CEL     GF   control          1
## 2   20160505_HTA2.0_0317_WTH_2R_(HTA-2_0).CEL     GF      drug          1
## 3   20160505_HTA2.0_0318_WTH_3R_(HTA-2_0).CEL    GFR   control          1
## 4   20160505_HTA2.0_0319_WTH_4R_(HTA-2_0).CEL    GFR      drug          1
## 5 20160616_HTA2.0_0333_WTH_1_R1_(HTA-2_0).CEL     GF   control          2
## 6 20160616_HTA2.0_0334_WTH_2_R1_(HTA-2_0).CEL     GF      drug          2
## 7 20160616_HTA2.0_0335_WTH_3_R2_(HTA-2_0).CEL    GFR   control          2
## 8 20160616_HTA2.0_0336_WTH_4_R1_(HTA-2_0).CEL    GFR      drug          2

4. Define the subset of .CEL files, read them in, and normalize them

dat <- read.celfiles(targets$FileName)

## Reading in : 20160505_HTA2.0_0316_WTH_1R_(HTA-2_0).CEL
## Reading in : 20160505_HTA2.0_0317_WTH_2R_(HTA-2_0).CEL
## Reading in : 20160505_HTA2.0_0318_WTH_3R_(HTA-2_0).CEL
## Reading in : 20160505_HTA2.0_0319_WTH_4R_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0333_WTH_1_R1_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0334_WTH_2_R1_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0335_WTH_3_R2_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0336_WTH_4_R1_(HTA-2_0).CEL

project.bgcorrect.norm.avg <- rma(dat, background=TRUE, normalize=TRUE)

## Background correcting
## Normalizing
## Calculating Expression

project.bgcorrect.norm.avg.filt <- exprs(project.bgcorrect.norm.avg)[which(rownames(project.bgcorrect.norm.avg) %in% Annotation[,1]),]

5. Create the nested design matrices

library(data.table) Two design matrices are created. The first will support generalize treatment response. The second will support generalize strain effects and GFR-specific treatment response.

design1 <- model.matrix(~Experiment+Treatment+Strain:Treatment)
design2 <- model.matrix(~Experiment+Strain+Strain:Treatment)

At this point, we are ready to begin the three tests: * GFR vs GF * treated vs. untreated * GFR-specific treatment response

A. GFR vs. GF

1. GFR vs. GF: Run “fit” algorithms and separate out the significantly different probes

eset <- project.bgcorrect.norm.avg.filt
fit <- lmFit(eset, design2)
fit <- eBayes(fit, trend=T, robust=T)
diff.strain <- topTable(fit, coef=3,p.value = 0.005, adjust.method = "none",  n = Inf )
setDT(diff.strain, keep.rownames = TRUE)[]

##                    rn      logFC  AveExpr          t      P.Value
##    1: TC05001205.hg.1 -4.5531345 5.223500 -38.868000 4.706093e-11
##    2: TC16001410.hg.1  4.3918860 6.312520  33.617711 1.649357e-10
##    3: TC19000805.hg.1  3.7059972 6.274601  26.758345 1.178837e-09
##    4: TC09000323.hg.1  4.1088311 7.802470  26.404206 1.321921e-09
##    5: TC16000857.hg.1  2.9086984 6.679754  22.556199 5.107017e-09
##   ---                                                            
## 2300: TC10001617.hg.1  0.4616078 8.260730   3.732878 4.970641e-03
## 2301: TC01006059.hg.1  0.4481677 6.296706   3.732348 4.974625e-03
## 2302: TC19001055.hg.1  0.5512773 5.654061   3.730880 4.988162e-03
## 2303: TC11001124.hg.1  0.4948796 3.856230   3.730358 4.989609e-03
## 2304: TC09002264.hg.1 -0.3925916 1.960243  -3.729650 4.994958e-03
##          adj.P.Val         B
##    1: 4.706093e-11 11.658063
##    2: 1.649357e-10 11.277893
##    3: 1.178837e-09 10.508148
##    4: 1.321921e-09 10.456226
##    5: 5.107017e-09  9.781645
##   ---                       
## 2300: 4.970641e-03 -2.117415
## 2301: 4.974625e-03 -2.118225
## 2302: 4.988162e-03 -2.120803
## 2303: 4.989609e-03 -2.121267
## 2304: 4.994958e-03 -2.122350

colnames(diff.strain)[1] <- "probe"
diff.strain <- dplyr::left_join(diff.strain,probe.gene.map,by="probe")

## Warning: Column `probe` joining character vector and factor, coercing into
## character vector

write.csv(diff.strain, "nested_interactions/DE.genes.strain.csv")
kable(diff.strain) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

probe	logFC	AveExpr	t	P.Value	adj.P.Val	B	name	description
TC05001205.hg.1	-4.5531345	5.223500	-38.868000	0.0000000	0.0000000	11.6580625	CDH10	cadherin 10, type 2 (T2-cadherin)
TC16001410.hg.1	4.3918860	6.312520	33.617711	0.0000000	0.0000000	11.2778931	—	—
TC19000805.hg.1	3.7059972	6.274601	26.758345	0.0000000	0.0000000	10.5081485	ERVV-2	endogenous retrovirus group V, member 2
TC09000323.hg.1	4.1088311	7.802470	26.404206	0.0000000	0.0000000	10.4562258	MAMDC2	MAM domain containing 2
TC16000857.hg.1	2.9086984	6.679754	22.556199	0.0000000	0.0000000	9.7816455	EMP2	epithelial membrane protein 2
TC0X000272.hg.1	-2.8060411	5.740524	-21.466361	0.0000000	0.0000000	9.5463411	GAGE12F	G antigen 12F
TC0X000273.hg.1	-2.8060411	5.740524	-21.466361	0.0000000	0.0000000	9.5463411	GAGE12F	G antigen 12F
TC0X002349.hg.1	-2.5868107	6.829243	-21.218810	0.0000000	0.0000000	9.4896345	GAGE12F	G antigen 12F
TC0X002315.hg.1	-2.7661393	7.185057	-21.065181	0.0000000	0.0000000	9.4538020	GAGE2A	G antigen 2A
TC0X002352.hg.1	-2.5715071	5.874566	-20.642291	0.0000000	0.0000000	9.3525556	GAGE12C	G antigen 12C
TC18000033.hg.1	2.7266696	5.971238	20.569892	0.0000000	0.0000000	9.3348285	ARHGAP28	Rho GTPase activating protein 28
TC06000999.hg.1	-4.1206627	5.219250	-21.962349	0.0000000	0.0000000	9.3326862	EYA4	EYA transcriptional coactivator and phosphatase 4
TC0X002353.hg.1	-2.5202898	6.528581	-20.384179	0.0000000	0.0000000	9.2888170	GAGE12C	G antigen 12C
TC0X002356.hg.1	-2.4897925	4.629859	-20.331395	0.0000000	0.0000000	9.2755960	GAGE13	G antigen 13
TC0X002354.hg.1	-2.5234273	6.530073	-20.308269	0.0000000	0.0000000	9.2697834	GAGE12C	G antigen 12C
TC0X000274.hg.1	-2.5569870	6.528453	-19.744592	0.0000000	0.0000000	9.1242093	GAGE12C	G antigen 12C
TC0X002348.hg.1	-2.4406342	6.755500	-19.634874	0.0000000	0.0000000	9.0949800	GAGE2D	G antigen 2D
TC0X002351.hg.1	-2.5338317	7.277475	-19.566420	0.0000000	0.0000000	9.0765919	GAGE2B	G antigen 2B
TC0X002350.hg.1	-2.7341929	7.179102	-19.375258	0.0000000	0.0000000	9.0246158	GAGE2D	G antigen 2D
TC01003130.hg.1	2.3320221	4.760865	19.228521	0.0000000	0.0000000	8.9840837	PDZK1P2	PDZ domain containing 1 pseudogene 2
TC0X002355.hg.1	-2.4543249	6.111781	-18.900929	0.0000000	0.0000000	8.8915523	GAGE2D	G antigen 2D
TC01003115.hg.1	2.4357645	4.958532	18.884316	0.0000000	0.0000000	8.8867832	PDZK1	PDZ domain containing 1
TC10000771.hg.1	2.2977573	6.061384	18.742951	0.0000000	0.0000000	8.8458968	INA	internexin neuronal intermediate filament protein, alpha
TC10001136.hg.1	2.6459800	5.842749	18.423074	0.0000000	0.0000000	8.7513290	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
TC19000804.hg.1	3.0987601	5.849916	18.609934	0.0000000	0.0000000	8.7325713	ERVV-1	endogenous retrovirus group V, member 1
TC10001559.hg.1	1.9997168	5.701522	18.126253	0.0000000	0.0000000	8.6609560	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1
TC01005783.hg.1	2.5107116	4.611186	18.003746	0.0000000	0.0000000	8.6228990	PDZK1P2	PDZ domain containing 1 pseudogene 2
TC0X002226.hg.1	3.0928614	5.486857	18.204127	0.0000000	0.0000000	8.5824487	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
TC01001099.hg.1	2.3608334	5.062843	17.821697	0.0000000	0.0000000	8.5655088	PDZK1	PDZ domain containing 1
TC0X002314.hg.1	-2.4174581	6.114995	-17.411589	0.0000000	0.0000000	8.4324535	GAGE1	G antigen 1
TC0X001704.hg.1	-2.5485992	8.236766	-17.066302	0.0000001	0.0000001	8.3162253	GAGE1	G antigen 1
TC0X002358.hg.1	-2.3305492	6.958519	-16.911697	0.0000001	0.0000001	8.2628919	GAGE12J	G antigen 12J
TC05002946.hg.1	1.9078739	4.500235	16.395138	0.0000001	0.0000001	8.0786606	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12
TC02002612.hg.1	-2.0703562	5.960741	-15.866699	0.0000001	0.0000001	7.8800955	COL5A2	collagen, type V, alpha 2
TC12000656.hg.1	-1.7830280	4.274430	-15.686821	0.0000001	0.0000001	7.8100560	NAV3	neuron navigator 3
TC17000383.hg.1	3.2700159	7.452543	16.008585	0.0000001	0.0000001	7.6851888	CCL2	chemokine (C-C motif) ligand 2
TC0X001917.hg.1	2.2417899	4.386576	15.221531	0.0000001	0.0000001	7.6102757	GPR50	G protein-coupled receptor 50
TC15000391.hg.1	2.7475303	6.054807	15.345341	0.0000002	0.0000002	7.5595898	SLC27A2	solute carrier family 27 (fatty acid transporter), member 2
TC07002625.hg.1	2.1705781	4.596821	14.882531	0.0000002	0.0000002	7.4714672	TMEM178B	transmembrane protein 178B
TC0X001353.hg.1	2.6550727	5.268306	15.125271	0.0000002	0.0000002	7.4667747	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
TC14000584.hg.1	-2.1136001	6.850269	-14.827603	0.0000002	0.0000002	7.4571813	IFI27	interferon, alpha-inducible protein 27
TC0X000121.hg.1	1.8359431	6.099373	14.634331	0.0000002	0.0000002	7.3734101	SCARNA23	small Cajal body-specific RNA 23
TC14001821.hg.1	-1.9538755	7.111216	-14.536396	0.0000002	0.0000002	7.3303149	IFI27	interferon, alpha-inducible protein 27
TC0X001301.hg.1	3.4297806	6.317122	15.726215	0.0000002	0.0000002	7.2818727	RP11-232D9.3	putative novel transcript
TC10001292.hg.1	-1.7030233	3.468667	-14.407712	0.0000002	0.0000002	7.2730159	A1CF	APOBEC1 complementation factor
TC0X000056.hg.1	1.6232809	5.191926	14.283030	0.0000002	0.0000002	7.2167582	RP11-1L9.1	putative novel transcript
TC12001572.hg.1	-2.8756291	4.164537	-14.790024	0.0000003	0.0000003	7.1270521	GTSF1	gametocyte specific factor 1
TC03002727.hg.1	-1.4882434	2.250786	-14.074646	0.0000003	0.0000003	7.1210742	—	—
TC01002163.hg.1	2.0346848	6.434913	13.984635	0.0000003	0.0000003	7.0790899	TNFRSF9	tumor necrosis factor receptor superfamily, member 9
TC18000230.hg.1	1.8558672	4.909035	13.906554	0.0000003	0.0000003	7.0423454	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7
TC0X001567.hg.1	2.1122313	7.052040	13.836061	0.0000003	0.0000003	7.0089100	—	—
TC10002643.hg.1	-2.4651663	2.946916	-14.079256	0.0000003	0.0000003	6.9442374	A1CF	APOBEC1 complementation factor
TC06003061.hg.1	-4.5453646	5.167030	-17.626552	0.0000003	0.0000003	6.7796067	EYA4	EYA transcriptional coactivator and phosphatase 4
TC08000482.hg.1	1.7859832	6.875943	13.349225	0.0000004	0.0000004	6.7710223	RDH10	retinol dehydrogenase 10 (all-trans)
TC02002606.hg.1	-2.7203953	6.063698	-13.739737	0.0000005	0.0000005	6.6809307	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TC05002033.hg.1	3.5150270	3.859194	15.247895	0.0000004	0.0000004	6.6613346	CTB-78F1.1	novel transcript
TC05000914.hg.1	1.8428962	5.828247	13.003191	0.0000005	0.0000005	6.5942255	TENM2	teneurin transmembrane protein 2
TC02004836.hg.1	1.9392723	4.590789	12.970967	0.0000006	0.0000006	6.5567303	COL4A4	collagen, type IV, alpha 4
TC10001850.hg.1	-2.2130822	5.914911	-12.802912	0.0000007	0.0000007	6.4105470	—	—
TC07001184.hg.1	2.6403278	5.937347	13.150706	0.0000007	0.0000007	6.3853682	CDCA7L	cell division cycle associated 7-like
TC05003420.hg.1	1.8198604	4.256193	12.551315	0.0000007	0.0000007	6.3508282	TAS2R1	taste receptor, type 2, member 1
TC14001944.hg.1	-1.5317766	3.844548	-12.427331	0.0000008	0.0000008	6.2848842	—	—
TC0Y000006.hg.1	1.8525996	7.149318	12.384789	0.0000008	0.0000008	6.2612494	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
TC08001062.hg.1	3.4649426	5.932169	14.314089	0.0000008	0.0000008	6.1992909	STC1	stanniocalcin 1
TC01002246.hg.1	1.5334028	4.857825	12.124010	0.0000010	0.0000010	6.1139206	AGMAT	agmatine ureohydrolase (agmatinase)
TC11001505.hg.1	-1.3656239	2.771855	-12.095097	0.0000010	0.0000010	6.0973227	MUC15	mucin 15, cell surface associated
TC04001682.hg.1	1.6916561	3.337425	12.077406	0.0000010	0.0000010	6.0871410	FAM198B	family with sequence similarity 198, member B
TC08001816.hg.1	2.1543578	6.020214	12.158625	0.0000010	0.0000010	6.0492473	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TC20000876.hg.1	2.4222103	8.177874	12.222641	0.0000010	0.0000010	6.0316400	SLPI	secretory leukocyte peptidase inhibitor
TC12003243.hg.1	1.4289268	5.963796	11.978720	0.0000011	0.0000011	6.0299746	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC0X001889.hg.1	1.6218309	6.986764	11.836082	0.0000012	0.0000012	5.9462313	FHL1	four and a half LIM domains 1
TC17001279.hg.1	2.3729951	2.745019	12.233174	0.0000013	0.0000013	5.8331082	—	—
TC02000468.hg.1	-1.2911258	6.130350	-11.612708	0.0000014	0.0000014	5.8123769	AC104135.3	novel transcript
TC0X002357.hg.1	-1.8018348	6.739722	-11.609825	0.0000014	0.0000014	5.8106276	GAGE10	G antigen 10
TC03000754.hg.1	1.8190809	5.302958	11.546577	0.0000015	0.0000015	5.7386922	CLSTN2	calsyntenin 2
TC15000166.hg.1	1.8797792	4.117830	11.557717	0.0000015	0.0000015	5.7279923	—	—
TC15000209.hg.1	1.8797792	4.117830	11.557717	0.0000015	0.0000015	5.7279923	—	—
TC15001127.hg.1	1.8797792	4.117830	11.557717	0.0000015	0.0000015	5.7279923	—	—
TC15001154.hg.1	1.8797792	4.117830	11.557717	0.0000015	0.0000015	5.7279923	—	—
TC04000829.hg.1	1.4610510	6.312645	11.446825	0.0000015	0.0000015	5.7107795	CPE	carboxypeptidase E
TC0X001180.hg.1	1.3302312	6.607296	11.389642	0.0000016	0.0000016	5.6753143	ITM2A	integral membrane protein 2A
TC0X000334.hg.1	3.0783327	4.334453	13.004737	0.0000016	0.0000016	5.5977384	FOXR2	forkhead box R2
TC11002587.hg.1	2.4146749	8.015338	11.600752	0.0000018	0.0000018	5.5874350	SAA1	serum amyloid A1
47424360_st	-2.3157597	2.704951	-11.826247	0.0000018	0.0000018	5.5505821	—	—
TC0X001710.hg.1	-1.4603467	8.377977	-11.151248	0.0000019	0.0000019	5.5249635	XAGE1E	X antigen family, member 1E
TC0X000568.hg.1	1.6241320	7.677247	11.105086	0.0000020	0.0000020	5.4953772	PLS3	plastin 3
TC02004744.hg.1	-3.3840908	6.610074	-12.956660	0.0000019	0.0000019	5.4607972	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TC01000261.hg.1	1.2980441	5.561521	11.007924	0.0000021	0.0000021	5.4325925	CDA	cytidine deaminase
TC11000149.hg.1	2.2829506	5.929862	11.390094	0.0000021	0.0000021	5.4259247	OLFML1	olfactomedin-like 1
TC05001200.hg.1	-1.3598306	3.695045	-10.974564	0.0000022	0.0000022	5.4108747	CDH12	cadherin 12, type 2 (N-cadherin 2)
TC0X000006.hg.1	1.6742274	6.419132	10.968300	0.0000022	0.0000022	5.4067871	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
TC18000084.hg.1	-3.5333197	5.557519	-13.461625	0.0000020	0.0000020	5.3937752	ANKRD30B	ankyrin repeat domain 30B
TC0X000727.hg.1	1.5238656	4.709963	10.873187	0.0000023	0.0000023	5.3443661	HMGB3	high mobility group box 3
TC02000469.hg.1	-1.7053474	4.922658	-10.917371	0.0000023	0.0000023	5.3439873	LINC01293	long intergenic non-protein coding RNA 1293
TC14000939.hg.1	-1.4004709	4.252581	-10.851530	0.0000024	0.0000024	5.3300580	RBM23	RNA binding motif protein 23
TC16000461.hg.1	-1.9163923	6.211444	-10.938824	0.0000024	0.0000024	5.3201256	GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
TC02003345.hg.1	-1.1964342	4.889804	-10.652189	0.0000028	0.0000028	5.1966723	—	—
TC13001724.hg.1	-1.6944106	4.667597	-10.671666	0.0000029	0.0000029	5.1700919	SOHLH2	spermatogenesis and oogenesis specific basic helix-loop-helix 2
TC12002388.hg.1	1.2568010	4.458115	10.540186	0.0000030	0.0000030	5.1203725	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC03000117.hg.1	2.9377821	4.253399	12.137992	0.0000029	0.0000029	5.1162612	ZNF385D-AS1	ZNF385D antisense RNA 1
TC0Y000250.hg.1	1.2788169	6.216424	10.523812	0.0000031	0.0000031	5.1091347	—	—
TC01002849.hg.1	-1.4748876	5.248295	-10.504113	0.0000031	0.0000031	5.0955878	GBP4	guanylate binding protein 4
TC04002799.hg.1	1.6518307	5.399797	10.519610	0.0000032	0.0000032	5.0807082	PDGFC	platelet derived growth factor C
TC17001341.hg.1	-3.1950614	3.248590	-12.563295	0.0000033	0.0000033	5.0110989	EVI2B	ecotropic viral integration site 2B
TC0X001738.hg.1	-1.3828854	3.665905	-10.297469	0.0000037	0.0000037	4.9515918	—	—
TC0X001916.hg.1	2.4967705	6.213314	11.029408	0.0000037	0.0000037	4.9348040	HMGB3	high mobility group box 3
TC07000815.hg.1	-1.4660476	6.072341	-10.254160	0.0000038	0.0000038	4.9209721	MEST	mesoderm specific transcript
TC08002237.hg.1	1.1360962	4.031137	10.197708	0.0000040	0.0000040	4.8808276	MSR1	macrophage scavenger receptor 1
TC11000238.hg.1	1.6967579	6.102286	10.194302	0.0000041	0.0000041	4.8405306	SAA1	serum amyloid A1
TC09002844.hg.1	2.4101593	6.017228	10.813457	0.0000042	0.0000042	4.8346378	LOC101448202	uncharacterized LOC101448202
47422398_st	1.2625838	2.241157	10.065289	0.0000044	0.0000044	4.7856152	—	—
TC14001387.hg.1	1.5497695	3.663662	10.089694	0.0000044	0.0000044	4.7819206	GALC	galactosylceramidase
TC12001837.hg.1	1.4845726	6.566662	10.049664	0.0000045	0.0000045	4.7742824	NTN4	netrin 4
TC0X000446.hg.1	-2.0331440	6.720509	-10.236301	0.0000046	0.0000046	4.7419971	KLHL4	kelch-like family member 4
TC06002022.hg.1	1.2669462	5.680262	10.000787	0.0000046	0.0000046	4.7386991	FYN	FYN proto-oncogene, Src family tyrosine kinase
TC04001673.hg.1	1.1815718	4.721450	9.994024	0.0000047	0.0000047	4.7337597	PDGFC	platelet derived growth factor C
TC12001910.hg.1	1.4978648	4.026265	9.996490	0.0000047	0.0000047	4.7204308	ALDH1L2	aldehyde dehydrogenase 1 family, member L2
TC0Y000249.hg.1	1.2075636	8.209751	9.799083	0.0000055	0.0000055	4.5896726	—	—
TC10000986.hg.1	-1.2322719	6.011860	-9.793117	0.0000055	0.0000055	4.5852109	AKR1C2	aldo-keto reductase family 1, member C2
TC09001704.hg.1	2.1810528	6.531796	10.159087	0.0000056	0.0000056	4.5681602	MIR3689A	microRNA 3689a
TC12000720.hg.1	1.8440667	3.721512	9.936748	0.0000059	0.0000059	4.5298068	—	—
TC11003478.hg.1	1.7854794	5.607612	9.868068	0.0000059	0.0000059	4.5295483	SAA2	serum amyloid A2
TC12003055.hg.1	1.6035505	4.034346	9.751502	0.0000060	0.0000060	4.5076352	ALDH1L2	aldehyde dehydrogenase 1 family, member L2
TC03001057.hg.1	-1.2033548	2.999343	-9.684519	0.0000060	0.0000060	4.5034366	RP11-655G22.1	novel trancript
TC10001573.hg.1	1.1664552	5.347944	9.668949	0.0000061	0.0000061	4.4916266	CRTAC1	cartilage acidic protein 1
TC05001933.hg.1	1.3330220	5.680301	9.646348	0.0000062	0.0000062	4.4744440	PDGFRB	platelet-derived growth factor receptor, beta polypeptide
TC16000154.hg.1	2.1494273	4.094056	10.159962	0.0000064	0.0000064	4.4569142	ATF7IP2	activating transcription factor 7 interacting protein 2
TC0Y000025.hg.1	1.1807186	8.514592	9.586430	0.0000065	0.0000065	4.4286674	TSPY1	testis specific protein, Y-linked 1
TC10000406.hg.1	1.6407148	4.765405	9.665819	0.0000066	0.0000066	4.4246689	TET1	tet methylcytosine dioxygenase 1
TC03002506.hg.1	2.9669699	5.129951	11.262251	0.0000072	0.0000072	4.3473614	—	—
TC18000415.hg.1	1.0062750	5.296211	9.479699	0.0000071	0.0000071	4.3463151	ANKRD29	ankyrin repeat domain 29
TC07000135.hg.1	1.9786668	5.419906	9.793465	0.0000072	0.0000072	4.3442169	LOC100506178	uncharacterized LOC100506178
TC06001305.hg.1	1.0892941	3.496183	9.361370	0.0000079	0.0000079	4.2537823	—	—
TC14000798.hg.1	1.0723366	4.996735	9.357535	0.0000079	0.0000079	4.2507614	SNORA28	small nucleolar RNA, H/ACA box 28
TC03003390.hg.1	1.1785867	5.756864	9.336461	0.0000080	0.0000080	4.2341361	COX17	COX17 cytochrome c oxidase copper chaperone
TC01001262.hg.1	1.2214719	5.517964	9.331957	0.0000081	0.0000081	4.2305774	NPR1	natriuretic peptide receptor 1
TC06000120.hg.1	1.5091710	7.377279	9.339247	0.0000081	0.0000081	4.2304489	RNF144B	ring finger protein 144B
TC05000071.hg.1	1.1126901	3.296564	9.305055	0.0000083	0.0000083	4.2092825	CTD-2256P15.1	novel transcript
TC0X001051.hg.1	-1.3153113	8.517732	-9.296030	0.0000083	0.0000083	4.2021236	XAGE1A	X antigen family, member 1A
TC0Y000365.hg.1	1.1551992	9.848786	9.289468	0.0000084	0.0000084	4.1969133	TSPY1	testis specific protein, Y-linked 1
TC03001673.hg.1	1.1098870	3.789023	9.265705	0.0000085	0.0000085	4.1780108	LSAMP	limbic system-associated membrane protein
TC20001032.hg.1	1.2476039	7.554981	9.252489	0.0000086	0.0000086	4.1674744	EEF1A2	eukaryotic translation elongation factor 1 alpha 2
TC0X002013.hg.1	1.0493470	9.790079	9.237452	0.0000087	0.0000087	4.1554669	APOO	apolipoprotein O
TC06000060.hg.1	-1.6645574	6.632648	-9.300554	0.0000088	0.0000088	4.1492468	DSP	desmoplakin
TC03003211.hg.1	1.5363987	5.945181	9.276532	0.0000088	0.0000088	4.1486652	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10
TC0Y000367.hg.1	1.1702662	9.307581	9.216965	0.0000089	0.0000089	4.1390714	TSPY3	testis specific protein, Y-linked 3
TC02001105.hg.1	-1.4808770	5.421672	-9.252168	0.0000090	0.0000090	4.1354178	COL3A1	collagen, type III, alpha 1
TC10000362.hg.1	-1.0259085	6.207284	-9.211405	0.0000089	0.0000089	4.1346151	BICC1	BicC family RNA binding protein 1
TC10001401.hg.1	1.1434244	6.919607	9.205527	0.0000090	0.0000090	4.1299002	—	—
47420725_st	-1.1431299	2.187253	-9.200558	0.0000090	0.0000090	4.1259122	—	—
TC0X001054.hg.1	-1.2776286	8.150130	-9.189486	0.0000091	0.0000091	4.1170173	XAGE1A	X antigen family, member 1A
TC19000279.hg.1	1.2031037	5.158430	9.189141	0.0000091	0.0000091	4.1167402	UCA1	urothelial cancer associated 1 (non-protein coding)
TC0X001053.hg.1	-1.3228901	8.523234	-9.176580	0.0000092	0.0000092	4.1066342	XAGE1A	X antigen family, member 1A
TC01003409.hg.1	1.5888027	4.867021	9.255574	0.0000093	0.0000093	4.1036770	ITLN1	intelectin 1 (galactofuranose binding)
TC0Y000248.hg.1	1.2073504	8.574307	9.152763	0.0000094	0.0000094	4.0874306	—	—
TC12001792.hg.1	-1.6017770	5.997145	-9.211948	0.0000095	0.0000095	4.0792134	KITLG	KIT ligand
TC12001907.hg.1	1.4590947	6.131961	9.143220	0.0000097	0.0000097	4.0606284	—	—
TC0Y000279.hg.1	-1.3613740	4.096580	-9.124189	0.0000098	0.0000098	4.0518781	DAZ4	deleted in azoospermia 4
TC0Y000036.hg.1	1.1534434	9.489651	9.102471	0.0000098	0.0000098	4.0466989	TSPY3	testis specific protein, Y-linked 3
TC05001406.hg.1	-1.2113036	4.324621	-9.093837	0.0000099	0.0000099	4.0396820	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif, 6
TC19002048.hg.1	1.3430798	5.496521	9.073961	0.0000101	0.0000101	4.0178084	—	—
TC0Y000364.hg.1	1.1577002	9.434086	9.047638	0.0000103	0.0000103	4.0020090	TSPY3	testis specific protein, Y-linked 3
TC12002778.hg.1	1.0948905	4.844336	9.047563	0.0000103	0.0000103	4.0019474	MGP	matrix Gla protein
TC10000389.hg.1	1.2475360	8.207404	9.040585	0.0000104	0.0000104	3.9962391	REEP3	receptor accessory protein 3
TC07000888.hg.1	1.8169693	5.866999	9.266808	0.0000106	0.0000106	3.9881511	TMEM178B	transmembrane protein 178B
TC0Y000038.hg.1	1.1707333	9.931856	9.021912	0.0000106	0.0000106	3.9809395	TSPY3	testis specific protein, Y-linked 3
TC18000610.hg.1	1.8897933	6.105710	9.249814	0.0000109	0.0000109	3.9603613	—	—
TC0X000923.hg.1	1.0446099	9.689360	8.990540	0.0000108	0.0000108	3.9551572	APOO	apolipoprotein O
TC03000182.hg.1	1.0504335	6.362228	8.958620	0.0000112	0.0000112	3.9288247	CTDSPL	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
TC09001703.hg.1	2.2730689	6.238768	9.662207	0.0000116	0.0000116	3.9269696	LOC101448202	uncharacterized LOC101448202
TC0Y000363.hg.1	1.1487990	9.654602	8.949913	0.0000112	0.0000112	3.9216243	TSPY1	testis specific protein, Y-linked 1
TC04000170.hg.1	-2.1581321	3.475756	-9.653518	0.0000116	0.0000116	3.9209239	RP11-552M14.1	novel transcript
TC10001676.hg.1	1.2915376	6.790546	8.931543	0.0000114	0.0000114	3.9064076	ABLIM1	actin binding LIM protein 1
TC0Y000366.hg.1	1.1499573	10.007143	8.927530	0.0000115	0.0000115	3.9030791	TSPY3	testis specific protein, Y-linked 3
TC0X001579.hg.1	1.5655155	7.680859	8.954786	0.0000116	0.0000116	3.8958866	—	—
TC14001693.hg.1	1.0071036	9.564307	8.916906	0.0000116	0.0000116	3.8942594	LGALS3	lectin, galactoside-binding, soluble, 3
TC01003266.hg.1	1.0639463	5.755506	8.913965	0.0000116	0.0000116	3.8918150	S100A4	S100 calcium binding protein A4
TC06001826.hg.1	-1.0985383	3.812962	-8.904366	0.0000117	0.0000117	3.8838341	COL21A1	collagen, type XXI, alpha 1
TC04001937.hg.1	-1.3044059	2.967363	-8.893943	0.0000121	0.0000121	3.8566862	—	—
TC0X001420.hg.1	1.4490258	8.144622	8.873374	0.0000121	0.0000121	3.8524608	SNORD61	small nucleolar RNA, C/D box 61
TC0X002025.hg.1	1.2218756	6.483837	8.863850	0.0000121	0.0000121	3.8500425	DMD	dystrophin
TC20001194.hg.1	1.2834587	5.835347	8.851619	0.0000123	0.0000123	3.8398088	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta
TC10002924.hg.1	-1.3099735	7.875050	-8.848510	0.0000123	0.0000123	3.8372056	AKR1C1	aldo-keto reductase family 1, member C1
TC01003497.hg.1	1.3456655	7.409502	8.845338	0.0000123	0.0000123	3.8345478	SLC19A2	solute carrier family 19 (thiamine transporter), member 2
TC01004151.hg.1	1.8668451	6.317209	9.052776	0.0000129	0.0000129	3.8063593	—	—
TC12000800.hg.1	0.8435168	1.546013	8.797766	0.0000129	0.0000129	3.7945699	—	—
TC01002043.hg.1	1.2684392	3.676378	8.777405	0.0000131	0.0000131	3.7773888	XX-CR54.1	novel transcript
TC17001342.hg.1	-3.2699601	4.554785	-11.013088	0.0000141	0.0000141	3.7647637	EVI2A	ecotropic viral integration site 2A
TC0X000301.hg.1	-1.1751086	7.218120	-8.728987	0.0000137	0.0000137	3.7363616	XAGE1A	X antigen family, member 1A
TC09000912.hg.1	1.4104827	3.608781	8.771386	0.0000138	0.0000138	3.7346486	RP11-3L8.3	novel transcript
TC0Y000362.hg.1	1.1472501	9.609119	8.702760	0.0000140	0.0000140	3.7140371	TSPY1	testis specific protein, Y-linked 1
TC08000695.hg.1	0.9993622	8.788362	8.680292	0.0000143	0.0000143	3.6948554	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
TC13000642.hg.1	-1.7891241	7.107205	-8.841072	0.0000146	0.0000146	3.6894693	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
TC0X001981.hg.1	1.1839314	3.769952	8.665763	0.0000145	0.0000145	3.6824235	HCCS	holocytochrome c synthase
TC07001722.hg.1	-1.0993170	3.500441	-8.661064	0.0000146	0.0000146	3.6783983	RELN	reelin
TC01003659.hg.1	-1.1422325	3.773498	-8.632083	0.0000150	0.0000150	3.6535209	KCNT2	potassium channel, subfamily T, member 2
TC0X002027.hg.1	1.1809994	4.881259	8.630226	0.0000150	0.0000150	3.6519239	—	—
TC10000808.hg.1	1.2179063	6.903001	8.626222	0.0000150	0.0000150	3.6484789	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)
TC02004032.hg.1	-1.6562125	5.583444	-8.789603	0.0000153	0.0000153	3.6471860	—	—
TC6_mcf_hap5000075.hg.1	0.9462399	4.117026	8.539739	0.0000163	0.0000163	3.5736641	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC6_qbl_hap6000081.hg.1	0.9462399	4.117026	8.539739	0.0000163	0.0000163	3.5736641	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC6_ssto_hap7000076.hg.1	0.9462399	4.117026	8.539739	0.0000163	0.0000163	3.5736641	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC08000127.hg.1	1.8908691	6.819296	8.786930	0.0000166	0.0000166	3.5727702	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TC6_dbb_hap3000083.hg.1	0.9362825	4.021221	8.534597	0.0000164	0.0000164	3.5691912	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC02001103.hg.1	-1.1611380	5.280469	-8.526682	0.0000165	0.0000165	3.5623002	GULP1	GULP, engulfment adaptor PTB domain containing 1
TC0X000303.hg.1	-1.1733808	7.753281	-8.499296	0.0000169	0.0000169	3.5384059	XAGE1A	X antigen family, member 1A
TC04000853.hg.1	1.7331593	5.106414	8.716640	0.0000175	0.0000175	3.5247184	GALNT7	polypeptide N-acetylgalactosaminyltransferase 7
TC10001089.hg.1	1.7901868	6.284917	8.686116	0.0000177	0.0000177	3.5097249	NEBL	nebulette
TC6_mann_hap4000074.hg.1	0.9370605	4.118256	8.424486	0.0000181	0.0000181	3.4727260	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC02002436.hg.1	-1.0888852	4.458407	-8.352381	0.0000194	0.0000194	3.4088493	AC012501.2	putative novel transcript
TC0X001723.hg.1	1.1272521	4.498133	8.342648	0.0000195	0.0000195	3.4001837	KLF8	Kruppel-like factor 8
TC05000218.hg.1	-1.4223900	5.734842	-8.379645	0.0000200	0.0000200	3.3842510	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
TC03002431.hg.1	-1.5550474	10.463519	-8.442124	0.0000203	0.0000203	3.3775847	—	—
TC07002602.hg.1	1.7012951	7.348155	8.437660	0.0000206	0.0000206	3.3640619	—	—
TC02003849.hg.1	1.1603073	3.545962	8.279157	0.0000208	0.0000208	3.3434011	—	—
TC14002198.hg.1	1.1235633	8.355274	8.277050	0.0000208	0.0000208	3.3415088	SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa
TC18000435.hg.1	-1.4198489	6.829112	-8.299551	0.0000211	0.0000211	3.3319764	DSC3	desmocollin 3
TC07002825.hg.1	-0.8666672	4.460367	-8.264497	0.0000210	0.0000210	3.3302265	—	—
TC03000023.hg.1	-1.2765234	3.077264	-8.290204	0.0000212	0.0000212	3.3267700	AC069277.2	novel transcript
TC09002178.hg.1	1.1859805	4.229717	8.252651	0.0000213	0.0000213	3.3195638	TMEM245	transmembrane protein 245
TC07001303.hg.1	1.1720792	6.097130	8.249688	0.0000213	0.0000213	3.3168946	AMPH	amphiphysin
TC07001037.hg.1	1.3195042	5.096141	8.253463	0.0000220	0.0000220	3.2907953	AC099552.3	novel transcript
TC01005092.hg.1	1.4088440	4.377643	8.276571	0.0000221	0.0000221	3.2875180	—	—
TC10001522.hg.1	1.3266350	5.299579	8.227272	0.0000226	0.0000226	3.2672895	PPP1R3C	protein phosphatase 1, regulatory subunit 3C
TC10002095.hg.1	1.2516833	8.134868	8.147305	0.0000235	0.0000235	3.2240557	REEP3	receptor accessory protein 3
TC18000078.hg.1	-1.1083201	3.543635	-8.143424	0.0000236	0.0000236	3.2205142	RNU6-316P	RNA, U6 small nuclear 316, pseudogene
TC07000544.hg.1	1.2045983	4.729966	8.149072	0.0000237	0.0000237	3.2165989	RP11-115N4.1	putative novel transcript
TC02004827.hg.1	0.8366292	2.843737	8.126845	0.0000240	0.0000240	3.2053624	—	—
TC19000401.hg.1	1.2412226	5.080381	8.117320	0.0000247	0.0000247	3.1801832	ZNF849P	zinc finger protein 849, pseudogene
TC06001976.hg.1	-1.0993037	5.259959	-8.083598	0.0000250	0.0000250	3.1656949	BVES	blood vessel epicardial substance
TC01001754.hg.1	1.1078969	6.288069	8.079508	0.0000251	0.0000251	3.1619325	SERTAD4	SERTA domain containing 4
TC0X000921.hg.1	0.9747775	7.218791	8.062488	0.0000255	0.0000255	3.1462551	ACOT9	acyl-CoA thioesterase 9
TC08001248.hg.1	-1.1427776	7.922389	-8.045015	0.0000259	0.0000259	3.1301259	TOX	thymocyte selection-associated high mobility group box
TC10001276.hg.1	0.9443085	5.522720	8.027440	0.0000264	0.0000264	3.1138676	ERCC6	excision repair cross-complementation group 6
TC09001705.hg.1	2.0992772	6.207133	8.671178	0.0000283	0.0000283	3.1043187	MIR3689C	microRNA 3689c
TC06000399.hg.1	0.8830371	3.999679	8.011013	0.0000268	0.0000268	3.0986394	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC03002202.hg.1	-1.0650546	3.551214	-8.010928	0.0000268	0.0000268	3.0985605	—	—
TC0X001841.hg.1	1.1538227	6.748605	8.004945	0.0000270	0.0000270	3.0930068	RP1-241P17.1	novel transcript
TC03001612.hg.1	-0.8604603	4.595756	-7.993019	0.0000273	0.0000273	3.0819234	ABI3BP	ABI family, member 3 (NESH) binding protein
TC05002857.hg.1	1.2708141	7.570777	7.991892	0.0000273	0.0000273	3.0808749	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
TC10002948.hg.1	1.1867076	7.420791	7.989820	0.0000274	0.0000274	3.0789479	AS3MT	arsenite methyltransferase
TC10001061.hg.1	-0.9103824	6.493107	-7.972210	0.0000278	0.0000278	3.0625456	NMT2	N-myristoyltransferase 2
TC09001707.hg.1	1.8148878	6.701362	8.243732	0.0000293	0.0000293	3.0433146	MIR3689B	microRNA 3689b
TC10002263.hg.1	1.2023701	7.171242	7.945885	0.0000286	0.0000286	3.0379599	C10orf32-ASMT	C10orf32-ASMT readthrough (NMD candidate)
TC0X000729.hg.1	0.8722640	4.516446	7.939875	0.0000287	0.0000287	3.0323358	GPR50	G protein-coupled receptor 50
TC14001369.hg.1	1.2395286	5.139353	7.954078	0.0000289	0.0000289	3.0272905	SNORA79	small nucleolar RNA, H/ACA box 79
TC15001217.hg.1	1.0223828	5.762249	7.923677	0.0000292	0.0000292	3.0171560	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)
TC0Y000229.hg.1	1.3192128	6.943494	7.930855	0.0000295	0.0000295	3.0079241	—	—
TC05001110.hg.1	-1.0951658	5.953963	-7.912366	0.0000295	0.0000295	3.0065393	LPCAT1	lysophosphatidylcholine acyltransferase 1
TC02003744.hg.1	-1.6091987	6.235813	-8.084243	0.0000301	0.0000301	3.0063857	COL3A1	collagen, type III, alpha 1
TC08000590.hg.1	1.0207827	6.909023	7.901740	0.0000298	0.0000298	2.9965510	SDC2	syndecan 2
TC0X001327.hg.1	0.9695460	5.754586	7.893666	0.0000301	0.0000301	2.9889529	C1GALT1C1	C1GALT1-specific chaperone 1
TC0X000288.hg.1	-0.9146582	3.504339	-7.893177	0.0000301	0.0000301	2.9884925	CCNB3	cyclin B3
TC06003411.hg.1	0.9903897	5.989058	7.877235	0.0000305	0.0000305	2.9734667	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1
TC13000120.hg.1	-1.0919634	5.036364	-7.869823	0.0000308	0.0000308	2.9664712	NBEA	neurobeachin
TC11000715.hg.1	0.9055295	5.653954	7.836923	0.0000318	0.0000318	2.9353397	MYEOV	myeloma overexpressed
TC16001574.hg.1	-1.4594671	5.841887	-7.922317	0.0000325	0.0000325	2.9249710	GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
TC6_cox_hap2000090.hg.1	0.9155897	3.909857	7.818387	0.0000324	0.0000324	2.9177448	HLA-DRA	major histocompatibility complex, class II, DR alpha
TC10002782.hg.1	1.7215913	5.094469	8.142726	0.0000337	0.0000337	2.9141513	PLCE1-AS1	PLCE1 antisense RNA 1
TC14000564.hg.1	1.0102478	5.734082	7.811306	0.0000326	0.0000326	2.9110129	SNORA11B	small nucleolar RNA, H/ACA box 11B
TC12001170.hg.1	1.2706980	9.257128	7.825888	0.0000327	0.0000327	2.9091904	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
47421299_st	0.8326628	1.662695	7.808884	0.0000327	0.0000327	2.9087079	—	—
TC11000177.hg.1	0.9518270	7.378730	7.800490	0.0000329	0.0000329	2.9007173	SBF2-AS1	SBF2 antisense RNA 1
TC0X000015.hg.1	1.4313954	6.390712	7.824251	0.0000345	0.0000345	2.8648443	XG	Xg blood group
TC11000630.hg.1	0.8452709	6.050826	7.750379	0.0000346	0.0000346	2.8528404	LOC101927789	putative ubiquitin-like protein FUBI-like protein ENSP00000310146-like
TC18000761.hg.1	1.0013014	6.935154	7.750011	0.0000346	0.0000346	2.8524883	SOCS6	suppressor of cytokine signaling 6
TC01003825.hg.1	1.4249302	4.614739	7.859131	0.0000352	0.0000352	2.8513562	TGFB2-AS1	TGFB2 antisense RNA 1 (head to head)
TC10002860.hg.1	0.9397085	2.400792	7.737123	0.0000351	0.0000351	2.8401257	—	—
TC16000455.hg.1	-1.0735111	6.233383	-7.715685	0.0000358	0.0000358	2.8195188	LPCAT2	lysophosphatidylcholine acyltransferase 2
TC08001811.hg.1	1.0104557	7.688404	7.696128	0.0000365	0.0000365	2.8006720	TUSC3	tumor suppressor candidate 3
TC01005812.hg.1	1.4587421	5.472725	7.814356	0.0000373	0.0000373	2.7955767	—	—
TC17001379.hg.1	0.9369706	5.825400	7.686185	0.0000369	0.0000369	2.7910723	—	—
TC02001553.hg.1	-1.3091356	5.148860	-7.720348	0.0000376	0.0000376	2.7793736	AC011747.6	putative novel transcript
TC10001544.hg.1	1.8104649	4.961328	8.118444	0.0000401	0.0000401	2.7640885	PLCE1-AS1	PLCE1 antisense RNA 1
TC19002012.hg.1	1.1325191	4.708697	7.658368	0.0000383	0.0000383	2.7558086	UCA1	urothelial cancer associated 1 (non-protein coding)
TC05000526.hg.1	0.9090329	6.637741	7.645067	0.0000385	0.0000385	2.7512479	SNORA13	small nucleolar RNA, H/ACA box 13
TC0X002038.hg.1	1.0569680	2.556772	7.629120	0.0000393	0.0000393	2.7311934	—	—
TC11002552.hg.1	1.1320799	7.088224	7.607255	0.0000399	0.0000399	2.7144455	SBF2-AS1	SBF2 antisense RNA 1
TC03002006.hg.1	1.0152225	3.499184	7.606683	0.0000400	0.0000400	2.7138875	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10
TC0X001625.hg.1	1.4289636	8.828375	7.656039	0.0000403	0.0000403	2.7119867	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
TC09002233.hg.1	1.1707290	5.754932	7.611807	0.0000405	0.0000405	2.7037896	—	—
TC01005700.hg.1	0.8207748	4.781148	7.594228	0.0000405	0.0000405	2.7017261	—	—
TC01005364.hg.1	0.8918745	4.333661	7.592748	0.0000405	0.0000405	2.7002799	—	—
TC07002955.hg.1	-1.2069182	5.137524	-7.614125	0.0000408	0.0000408	2.6970028	—	—
TC02000944.hg.1	-0.8564523	3.390984	-7.585064	0.0000408	0.0000408	2.6927662	GALNT13	polypeptide N-acetylgalactosaminyltransferase 13
TC20000662.hg.1	0.9852372	6.251970	7.561412	0.0000418	0.0000418	2.6695942	—	—
TC06000148.hg.1	0.8218920	4.065303	7.556648	0.0000420	0.0000420	2.6649180	RP3-369A17.4	novel transcript
TC02004646.hg.1	-0.8637808	3.150427	-7.500135	0.0000445	0.0000445	2.6092408	—	—
TC15001777.hg.1	1.2276340	4.970987	7.530982	0.0000447	0.0000447	2.6088384	—	—
TC10000425.hg.1	0.9340390	5.242038	7.481918	0.0000454	0.0000454	2.5912093	H2AFY2	H2A histone family, member Y2
TC0X002300.hg.1	1.2879565	5.902382	7.524889	0.0000457	0.0000457	2.5905976	TSPAN7	tetraspanin 7
TC01003411.hg.1	0.8596142	3.849933	7.475658	0.0000456	0.0000456	2.5850042	ITLN2	intelectin 2
TC08001988.hg.1	-1.0477389	5.093939	-7.470520	0.0000459	0.0000459	2.5799072	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
TC18000542.hg.1	1.2194306	4.839527	7.488454	0.0000467	0.0000467	2.5670852	ALPK2	alpha-kinase 2
TC17000529.hg.1	0.8651701	6.825663	7.431080	0.0000478	0.0000478	2.5406730	COASY	CoA synthase
TC09001547.hg.1	0.8458728	4.654579	7.428381	0.0000479	0.0000479	2.5379803	STOM	stomatin
TC18000815.hg.1	1.1522853	7.818087	7.426490	0.0000480	0.0000480	2.5360942	LAMA1	laminin, alpha 1
TC0Y000001.hg.1	0.9038413	5.542158	7.418657	0.0000484	0.0000484	2.5282746	PLCXD1	phosphatidylinositol-specific phospholipase C, X domain containing 1
TC10001725.hg.1	0.8349215	5.107565	7.414480	0.0000486	0.0000486	2.5241012	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
TC09000961.hg.1	-0.9248048	4.694463	-7.412609	0.0000487	0.0000487	2.5222311	MIR31HG	MIR31 host gene (non-protein coding)
TC17001566.hg.1	1.0180860	6.004312	7.410395	0.0000488	0.0000488	2.5200183	—	—
TC04000158.hg.1	-0.9653889	5.529875	-7.394602	0.0000496	0.0000496	2.5042123	SLIT2	slit homolog 2 (Drosophila)
TC02004894.hg.1	0.8233798	3.958608	7.394216	0.0000496	0.0000496	2.5038262	—	—
TC08000324.hg.1	1.1137825	6.594341	7.394172	0.0000496	0.0000496	2.5037818	AP3M2	adaptor-related protein complex 3, mu 2 subunit
TC01002382.hg.1	0.9648971	4.437178	7.388478	0.0000499	0.0000499	2.4980759	PAQR7	progestin and adipoQ receptor family member VII
TC06001343.hg.1	0.9672936	9.224783	7.382722	0.0000502	0.0000502	2.4923028	HIST1H2AB	histone cluster 1, H2ab
TC16000783.hg.1	-0.9457008	6.521445	-7.371100	0.0000508	0.0000508	2.4806341	ABCA3	ATP-binding cassette, sub-family A (ABC1), member 3
TC0X001317.hg.1	0.7576764	1.930718	7.366299	0.0000511	0.0000511	2.4758092	RP3-327A19.5	novel transcript, antisense to AKAP14
TC09002626.hg.1	1.6576109	5.380378	7.672012	0.0000537	0.0000537	2.4707906	—	—
TC03002177.hg.1	0.8363195	5.286966	7.354072	0.0000517	0.0000517	2.4635075	AC128709.3	novel transcript
TC17002197.hg.1	1.0979549	5.796353	7.356873	0.0000518	0.0000518	2.4619984	LOC100287525	uncharacterized LOC100287525
TC15001541.hg.1	1.1785223	5.006572	7.373169	0.0000522	0.0000522	2.4573938	CA12	carbonic anhydrase XII
TC18000309.hg.1	1.1218165	7.461647	7.339202	0.0000525	0.0000525	2.4485213	LAMA1	laminin, alpha 1
TC04002626.hg.1	-0.9725254	4.116676	-7.327413	0.0000532	0.0000532	2.4366204	—	—
TC07002456.hg.1	1.0808484	4.835468	7.324125	0.0000538	0.0000538	2.4264471	—	—
TC03001356.hg.1	1.0410485	3.281251	7.312200	0.0000540	0.0000540	2.4212368	RP11-24F11.2	novel transcript
TC18000524.hg.1	0.8348764	2.827281	7.307004	0.0000543	0.0000543	2.4159766	CCDC68	coiled-coil domain containing 68
TC06003367.hg.1	0.7623070	3.062574	7.290475	0.0000552	0.0000552	2.3992182	—	—
TC12000509.hg.1	1.4369114	7.425786	7.348409	0.0000570	0.0000570	2.3808713	COQ10A	coenzyme Q10 homolog A (S. cerevisiae)
TC07001188.hg.1	-0.9263287	4.360095	-7.253655	0.0000574	0.0000574	2.3617643	LOC401312	uncharacterized LOC401312
TC12001276.hg.1	0.8163872	3.918912	7.249503	0.0000576	0.0000576	2.3575292	MGP	matrix Gla protein
TC10002520.hg.1	1.4268606	4.659336	7.390715	0.0000592	0.0000592	2.3535138	LRRC37A6P	leucine rich repeat containing 37, member A6, pseudogene
TC0Y000196.hg.1	-0.8437749	3.343932	-7.228102	0.0000590	0.0000590	2.3356685	DAZ4	deleted in azoospermia 4
TC04001886.hg.1	1.1679107	4.486881	7.252768	0.0000595	0.0000595	2.3316201	SORCS2	sortilin-related VPS10 domain containing receptor 2
TC01004998.hg.1	1.1122853	7.337490	7.214509	0.0000598	0.0000598	2.3217531	G0S2	G0/G1 switch 2
TC0X000824.hg.1	-0.9571609	6.749290	-7.213916	0.0000598	0.0000598	2.3211455	VCX2	variable charge, X-linked 2
TC09000679.hg.1	0.8404205	6.005286	7.209365	0.0000601	0.0000601	2.3164817	DNM1	dynamin 1
TC06000162.hg.1	1.0671586	6.362248	7.201390	0.0000606	0.0000606	2.3083006	HIST1H3A	histone cluster 1, H3a
TC09002865.hg.1	1.4674469	5.878806	7.340795	0.0000625	0.0000625	2.3017835	CLIC3	chloride intracellular channel 3
TC07001565.hg.1	-0.7681264	4.076257	-7.176254	0.0000622	0.0000622	2.2824641	PCLO	piccolo presynaptic cytomatrix protein
TC0X001581.hg.1	1.2583189	3.237536	7.235364	0.0000634	0.0000634	2.2752084	—	—
TC05000441.hg.1	-0.9336387	7.976179	-7.136039	0.0000649	0.0000649	2.2409581	POLR3G	polymerase (RNA) III (DNA directed) polypeptide G (32kD)
TC12003106.hg.1	0.8697404	3.994994	7.099819	0.0000675	0.0000675	2.2033962	LOC283454	uncharacterized LOC283454
TC11003373.hg.1	1.1035245	2.339523	7.118049	0.0000694	0.0000694	2.1825344	—	—
TC03003304.hg.1	0.9549554	5.387083	7.079051	0.0000690	0.0000690	2.1817819	—	—
TC05001558.hg.1	-0.7437344	2.462560	-7.075728	0.0000692	0.0000692	2.1783182	EDIL3	EGF-like repeats and discoidin I-like domains 3
TC0X002235.hg.1	1.0369433	7.473370	7.049470	0.0000712	0.0000712	2.1508987	FAM127B	family with sequence similarity 127, member B
TC17000062.hg.1	1.0524028	7.025883	7.044157	0.0000716	0.0000716	2.1453391	LOC101928000	uncharacterized LOC101928000
TC06001917.hg.1	-0.8101003	6.925560	-7.043204	0.0000717	0.0000717	2.1443413	TBX18	T-box 18
TC0X000027.hg.1	-0.8854368	6.731495	-7.042859	0.0000717	0.0000717	2.1439800	VCX	variable charge, X-linked
TC05001243.hg.1	0.7586185	4.831541	7.033894	0.0000724	0.0000724	2.1345900	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12
TC10000434.hg.1	0.8559422	6.466244	7.033230	0.0000724	0.0000724	2.1338943	SGPL1	sphingosine-1-phosphate lyase 1
TC10001329.hg.1	1.1398114	6.786632	7.034167	0.0000735	0.0000735	2.1213936	JMJD1C	jumonji domain containing 1C
TC12002515.hg.1	0.9606684	2.223321	7.033033	0.0000736	0.0000736	2.1202081	—	—
TC11002216.hg.1	-1.1606141	2.058663	-7.099625	0.0000761	0.0000761	2.1020755	—	—
TC0Y000189.hg.1	0.7633041	4.918609	6.962692	0.0000781	0.0000781	2.0596353	RBMY2EP	RNA binding motif protein, Y-linked, family 2, member E pseudogene
TC05001301.hg.1	0.9507761	5.220308	6.960887	0.0000783	0.0000783	2.0577268	SNORD72	small nucleolar RNA, C/D box 72
TC11000179.hg.1	1.2473977	8.201189	6.981015	0.0000792	0.0000792	2.0513404	SBF2-AS1	SBF2 antisense RNA 1
TC0X000030.hg.1	-1.0249335	7.675600	-6.946928	0.0000795	0.0000795	2.0429496	VCX3B	variable charge, X-linked 3B
TC01001197.hg.1	1.0770255	4.908163	6.942704	0.0000813	0.0000813	2.0233496	ANXA9	annexin A9
TC10000401.hg.1	-1.0090517	5.993515	-6.926788	0.0000812	0.0000812	2.0215844	MYPN	myopalladin
TC03001750.hg.1	-0.9410378	6.144056	-6.907208	0.0000830	0.0000830	2.0007613	MGLL	monoglyceride lipase
TC08001521.hg.1	-0.9855613	3.589047	-6.904519	0.0000832	0.0000832	1.9978982	ANGPT1	angiopoietin 1
TC02004703.hg.1	-1.2432651	6.931658	-6.937092	0.0000840	0.0000840	1.9949228	CHN1	chimerin 1
TC10001851.hg.1	-0.7973258	4.581446	-6.901308	0.0000835	0.0000835	1.9944768	—	—
TC09000605.hg.1	0.9884456	5.994292	6.898589	0.0000837	0.0000837	1.9915795	LOC100288842	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 pseudogene
TC15002646.hg.1	0.8046456	6.255976	6.895662	0.0000840	0.0000840	1.9884587	CTSH	cathepsin H
TC02004919.hg.1	0.7330642	4.497080	6.884148	0.0000851	0.0000851	1.9761721	HOXD10	homeobox D10
TC10001626.hg.1	1.0323481	8.530814	6.883967	0.0000851	0.0000851	1.9759789	NT5C2	5-nucleotidase, cytosolic II
TC07002624.hg.1	2.2097628	5.462258	7.871821	0.0000988	0.0000988	1.9757181	—	—
TC01004452.hg.1	1.3166473	3.173098	7.005205	0.0000873	0.0000873	1.9734299	AK4	adenylate kinase 4
TC12002734.hg.1	1.2670388	10.329069	6.944758	0.0000867	0.0000867	1.9697930	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
TC05002246.hg.1	0.8257556	8.012415	6.876179	0.0000858	0.0000858	1.9676576	—	—
TC05001051.hg.1	0.7992119	4.999268	6.876084	0.0000858	0.0000858	1.9675559	HMGB3P22	high mobility group box 3 pseudogene 22
PSR01002166.hg.1	0.7512045	4.048012	6.868741	0.0000865	0.0000865	1.9597036	—	—
TC10001627.hg.1	1.4714920	5.700583	7.050473	0.0000914	0.0000914	1.9417441	—	—
TC19001418.hg.1	-0.8935862	1.892858	-6.862889	0.0000883	0.0000883	1.9411277	—	—
TC06001128.hg.1	-0.8443546	5.954325	-6.850322	0.0000882	0.0000882	1.9399727	SYNJ2	synaptojanin 2
PSR14014334.hg.1	0.8156230	9.657057	6.842755	0.0000890	0.0000890	1.9318546	—	—
TC02002484.hg.1	-1.0485310	5.548549	-6.851607	0.0000895	0.0000895	1.9283886	FIGN	fidgetin
TC18000077.hg.1	-0.9997018	4.960970	-6.826619	0.0000910	0.0000910	1.9106393	ANKRD20A5P	ankyrin repeat domain 20 family, member A5, pseudogene
TC14001926.hg.1	1.1463893	4.100752	6.854772	0.0000919	0.0000919	1.9071257	SLC7A7	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TC02002504.hg.1	-0.7937316	6.674210	-6.818570	0.0000914	0.0000914	1.9058542	STK39	serine threonine kinase 39
TC04002887.hg.1	1.1140588	3.014814	6.839703	0.0000934	0.0000934	1.8910847	SORBS2	sorbin and SH3 domain containing 2
TC01002211.hg.1	0.8931941	6.275450	6.793403	0.0000939	0.0000939	1.8787137	DHRS3	dehydrogenase/reductase (SDR family) member 3
TC0X000732.hg.1	1.2366518	6.960756	6.820542	0.0000953	0.0000953	1.8706427	PASD1	PAS domain containing 1
TC06001509.hg.1	0.6737435	1.937908	6.783824	0.0000949	0.0000949	1.8683618	—	—
TC06003695.hg.1	-0.9979790	7.407310	-6.782679	0.0000950	0.0000950	1.8671234	DST	dystonin
TC16000189.hg.1	0.7842286	7.306058	6.782361	0.0000950	0.0000950	1.8667786	MPV17L	MPV17 mitochondrial membrane protein-like
TC05002960.hg.1	-1.0947212	3.768603	-6.802039	0.0000960	0.0000960	1.8614497	GDNF	glial cell derived neurotrophic factor
TC0X001314.hg.1	0.8051429	7.025037	6.770769	0.0000963	0.0000963	1.8542319	RPL39	ribosomal protein L39
TC01004729.hg.1	0.9787148	3.151559	6.764648	0.0000974	0.0000974	1.8437757	—	—
TC0X001627.hg.1	1.6503803	5.904845	7.103068	0.0001057	0.0001057	1.8276452	PDK3	pyruvate dehydrogenase kinase, isozyme 3
TC12000799.hg.1	0.7910574	3.629183	6.740624	0.0000995	0.0000995	1.8215177	STAB2	stabilin 2
TC0X001325.hg.1	1.0377000	7.487785	6.739002	0.0000997	0.0000997	1.8197542	LAMP2	lysosomal-associated membrane protein 2
TC05000904.hg.1	-0.6889845	2.789523	-6.722350	0.0001015	0.0001015	1.8016265	GABRG2	gamma-aminobutyric acid (GABA) A receptor, gamma 2
TC17001157.hg.1	0.9482246	7.675363	6.722268	0.0001015	0.0001015	1.8015369	PMP22	peripheral myelin protein 22
TC11000898.hg.1	1.2963052	6.236784	6.802795	0.0001032	0.0001032	1.8015062	NAALAD2	N-acetylated alpha-linked acidic dipeptidase 2
TC09002426.hg.1	-0.8294134	4.942178	-6.708938	0.0001030	0.0001030	1.7869980	MIR31HG	MIR31 host gene (non-protein coding)
TC16001913.hg.1	0.8917922	5.198909	6.699784	0.0001041	0.0001041	1.7769996	APOOP5	apolipoprotein O pseudogene 5
TC08000694.hg.1	-0.8422821	3.938238	-6.698559	0.0001042	0.0001042	1.7756606	COLEC10	collectin sub-family member 10 (C-type lectin)
TC08002509.hg.1	0.9177817	7.237045	6.687410	0.0001055	0.0001055	1.7634661	TATDN1	TatD DNase domain containing 1
TC03003040.hg.1	1.7364870	3.145141	7.215774	0.0001181	0.0001181	1.7506003	—	—
TC11002009.hg.1	-0.8358602	7.412612	-6.671878	0.0001074	0.0001074	1.7464489	CPT1A	carnitine palmitoyltransferase 1A (liver)
TC0X000658.hg.1	0.7252585	5.728164	6.667948	0.0001078	0.0001078	1.7421386	FHL1	four and a half LIM domains 1
TC15001895.hg.1	0.8274449	1.433147	6.679103	0.0001081	0.0001081	1.7419037	—	—
TC08001983.hg.1	-1.7165532	4.818833	-7.169017	0.0001189	0.0001189	1.7388102	—	—
TC14001988.hg.1	0.7897558	3.225826	6.661116	0.0001087	0.0001087	1.7346385	—	—
TC10002216.hg.1	0.7752368	6.750066	6.658561	0.0001090	0.0001090	1.7318323	PCGF5	polycomb group ring finger 5
TC0X001927.hg.1	1.0514430	5.404172	6.668314	0.0001098	0.0001098	1.7268219	DUSP9	dual specificity phosphatase 9
TC12000162.hg.1	0.7216666	3.634231	6.651413	0.0001098	0.0001098	1.7239769	—	—
TC11001273.hg.1	1.7405754	8.401357	6.994320	0.0001176	0.0001176	1.7231022	H19	H19, imprinted maternally expressed transcript (non-protein coding)
TC05002281.hg.1	-0.8019326	3.609238	-6.649865	0.0001100	0.0001100	1.7222742	LINC01194	long intergenic non-protein coding RNA 1194
TC07002695.hg.1	1.1425070	5.655533	6.680827	0.0001110	0.0001110	1.7200902	—	—
TC09000945.hg.1	0.9898969	4.760601	6.655058	0.0001105	0.0001105	1.7198861	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2
TC10001130.hg.1	1.3634711	4.621186	6.793549	0.0001141	0.0001141	1.7164324	LRRC37A6P	leucine rich repeat containing 37, member A6, pseudogene
TC11002729.hg.1	0.9561825	5.738928	6.634890	0.0001119	0.0001119	1.7057909	—	—
TC09000652.hg.1	0.8269621	6.218910	6.625211	0.0001131	0.0001131	1.6951203	PBX3	pre-B-cell leukemia homeobox 3
TC02002320.hg.1	-0.8248969	7.147072	-6.624074	0.0001132	0.0001132	1.6938655	SMPD4	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
TC13000298.hg.1	-0.7579479	5.336949	-6.623365	0.0001133	0.0001133	1.6930832	SLAIN1	SLAIN motif family, member 1
TC21001067.hg.1	1.0025518	4.992650	6.607123	0.0001171	0.0001171	1.6628870	TPTE	transmembrane phosphatase with tensin homology
TC19002708.hg.1	-0.9565842	9.180586	-6.590742	0.0001175	0.0001175	1.6570138	PSG1	pregnancy specific beta-1-glycoprotein 1
TC02004579.hg.1	-0.9017682	7.730477	-6.580674	0.0001189	0.0001189	1.6458523	SMPD4	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
TC12001916.hg.1	1.4829255	6.276102	6.784334	0.0001247	0.0001247	1.6410182	NUAK1	NUAK family, SNF1-like kinase, 1
TC09000934.hg.1	1.1007966	5.987464	6.586440	0.0001218	0.0001218	1.6269510	SCARNA8	small Cajal body-specific RNA 8
TC0Y000056.hg.1	-0.9081900	5.757100	-6.559325	0.0001217	0.0001217	1.6221383	VCY	variable charge, Y-linked
TC03002464.hg.1	0.8471322	5.371993	6.540501	0.0001243	0.0001243	1.6011760	PHLDB2	pleckstrin homology-like domain, family B, member 2
TC15000329.hg.1	0.6938776	4.819675	6.534018	0.0001253	0.0001253	1.5939443	MAP1A	microtubule-associated protein 1A
TC12001168.hg.1	0.9695128	6.354506	6.531320	0.0001256	0.0001256	1.5909340	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14
TC0X002285.hg.1	0.8019320	9.111563	6.529781	0.0001258	0.0001258	1.5892153	—	—
TC0Y000154.hg.1	1.0671648	6.159051	6.539218	0.0001270	0.0001270	1.5833227	TSPY5P	testis specific protein, Y-linked 5, pseudogene
TC20000215.hg.1	0.7459066	6.324682	6.522039	0.0001270	0.0001270	1.5805687	DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta
TC0X001299.hg.1	1.3264780	6.333047	6.630289	0.0001301	0.0001301	1.5801894	CT83	cancer/testis antigen 83
TC17002269.hg.1	0.7433085	4.588692	6.520992	0.0001271	0.0001271	1.5793983	—	—
TC19002054.hg.1	0.8652358	6.617801	6.520162	0.0001272	0.0001272	1.5784709	—	—
TC01001900.hg.1	0.8092393	5.315499	6.518209	0.0001275	0.0001275	1.5762873	RAB4A	RAB4A, member RAS oncogene family
TC0X002142.hg.1	1.2449980	6.418803	6.575303	0.0001300	0.0001300	1.5704627	—	—
TC18000313.hg.1	2.4260682	2.425847	7.896873	0.0001612	0.0001612	1.5673122	—	—
TC02001552.hg.1	-0.8363947	3.979527	-6.508406	0.0001289	0.0001289	1.5653209	AC011747.4	novel transcript
TC02001192.hg.1	-1.0717357	7.089189	-6.518873	0.0001293	0.0001293	1.5650294	BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)
TC07002240.hg.1	0.9694484	8.141400	6.507436	0.0001291	0.0001291	1.5642345	—	—
TC01001950.hg.1	0.7476915	6.064684	6.500390	0.0001301	0.0001301	1.5563426	GPR137B	G protein-coupled receptor 137B
TC03001721.hg.1	1.7004131	3.807595	6.984693	0.0001454	0.0001454	1.5449907	RNA5SP137	RNA, 5S ribosomal pseudogene 137
TC18000082.hg.1	-0.8049395	3.744132	-6.481503	0.0001329	0.0001329	1.5351546	CYP4F35P	cytochrome P450, family 4, subfamily F, polypeptide 35, pseudogene
TC09002258.hg.1	0.8967880	7.216678	6.479438	0.0001332	0.0001332	1.5328343	PBX3	pre-B-cell leukemia homeobox 3
TC14001079.hg.1	0.8983632	6.295800	6.471119	0.0001345	0.0001345	1.5234840	KLHL28	kelch-like family member 28
TC11003248.hg.1	0.8802840	7.229292	6.467029	0.0001351	0.0001351	1.5188831	C2CD3	C2 calcium-dependent domain containing 3
TC16000559.hg.1	0.8705009	4.976805	6.466845	0.0001351	0.0001351	1.5186757	CDH1	cadherin 1, type 1, E-cadherin (epithelial)
TC19000926.hg.1	0.8281159	4.939564	6.462303	0.0001358	0.0001358	1.5135640	ZFP28	ZFP28 zinc finger protein
TC11003304.hg.1	-1.3829701	2.414716	-6.736083	0.0001478	0.0001478	1.4924829	—	—
TC11001966.hg.1	-0.8645572	5.740782	-6.441001	0.0001392	0.0001392	1.4895481	SLC29A2	solute carrier family 29 (equilibrative nucleoside transporter), member 2
TC02001021.hg.1	0.8535431	8.926028	6.435890	0.0001400	0.0001400	1.4837765	CYBRD1	cytochrome b reductase 1
TC0X000925.hg.1	1.0425784	7.237272	6.440177	0.0001403	0.0001403	1.4828259	KLHL15	kelch-like family member 15
TC02001159.hg.1	-0.7972583	6.843691	-6.428776	0.0001411	0.0001411	1.4757359	SPATS2L	spermatogenesis associated, serine-rich 2-like
TC0X001880.hg.1	1.0467952	7.077969	6.429832	0.0001423	0.0001423	1.4692618	—	—
TC0X000911.hg.1	0.8409740	7.308740	6.420020	0.0001425	0.0001425	1.4658314	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
TC0X001493.hg.1	0.9439128	5.764831	6.416522	0.0001431	0.0001431	1.4618709	GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3
TC06001271.hg.1	0.7722885	6.392763	6.410687	0.0001440	0.0001440	1.4552619	ELOVL2	ELOVL fatty acid elongase 2
47421979_st	0.8844264	3.526882	6.389418	0.0001476	0.0001476	1.4311278	—	—
TC19002485.hg.1	-2.2566884	6.581391	-7.317608	0.0001767	0.0001767	1.4284550	TGFB1	transforming growth factor, beta 1
TC0X000120.hg.1	0.9192385	8.175851	6.384652	0.0001484	0.0001484	1.4257109	POLA1	polymerase (DNA directed), alpha 1, catalytic subunit
TC0X002363.hg.1	-0.9238200	4.873513	-6.380396	0.0001491	0.0001491	1.4208707	PAGE2	P antigen family, member 2 (prostate associated)
TC0X001181.hg.1	0.7355079	3.114929	6.367944	0.0001513	0.0001513	1.4066956	CHMP1B2P	charged multivesicular body protein 1B2, pseudogene
TC14001316.hg.1	0.7064588	5.765580	6.367290	0.0001514	0.0001514	1.4059504	ACYP1	acylphosphatase 1, erythrocyte (common) type
TC0X002210.hg.1	0.6917576	2.116250	6.364837	0.0001518	0.0001518	1.4031549	—	—
TC07003044.hg.1	-0.8676782	3.277478	-6.362621	0.0001522	0.0001522	1.4006295	LINC01112	long intergenic non-protein coding RNA 1112
TC07001355.hg.1	0.9400396	8.408208	6.361673	0.0001523	0.0001523	1.3995487	IGFBP3	insulin-like growth factor binding protein 3
TC16001160.hg.1	0.8273425	5.212874	6.360898	0.0001525	0.0001525	1.3986643	APOOP5	apolipoprotein O pseudogene 5
TC19001553.hg.1	-1.1407031	6.311085	-6.385771	0.0001550	0.0001550	1.3901254	TGFB1	transforming growth factor, beta 1
TC01001079.hg.1	-0.8695282	5.750483	-6.352757	0.0001539	0.0001539	1.3893771	RNU1-59P	RNA, U1 small nuclear 59, pseudogene
TC02004518.hg.1	0.7450625	6.507159	6.349848	0.0001544	0.0001544	1.3860556	—	—
TC02001255.hg.1	1.1133804	8.082657	6.361675	0.0001558	0.0001558	1.3810995	—	—
TC20000621.hg.1	0.8018302	5.895657	6.342614	0.0001557	0.0001557	1.3777915	JAG1	jagged 1
TC01005268.hg.1	1.1066081	7.983498	6.346827	0.0001584	0.0001584	1.3645647	DHRS3	dehydrogenase/reductase (SDR family) member 3
TC05000165.hg.1	1.1345833	4.465043	6.379845	0.0001609	0.0001609	1.3581195	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
TC06003783.hg.1	-1.0789901	7.365285	-6.334299	0.0001597	0.0001597	1.3551746	POPDC3	popeye domain containing 3
TC15001564.hg.1	0.8031394	7.398749	6.322233	0.0001594	0.0001594	1.3544690	—	—
TC19001992.hg.1	0.7545804	7.514990	6.309508	0.0001618	0.0001618	1.3398769	—	—
TC15000371.hg.1	1.1337824	2.204123	6.413847	0.0001663	0.0001663	1.3377883	—	—
TC19002478.hg.1	0.7728628	5.409572	6.299047	0.0001637	0.0001637	1.3278632	—	—
TC19002116.hg.1	0.9805830	5.707252	6.306447	0.0001646	0.0001646	1.3249845	—	—
TC06000010.hg.1	-0.9763151	5.812012	-6.305622	0.0001648	0.0001648	1.3240394	FOXF2	forkhead box F2
TC03000597.hg.1	0.7428720	4.074242	6.272988	0.0001687	0.0001687	1.2978699	LSAMP-AS1	uncharacterized LOC101926903
TC0X000714.hg.1	0.8508556	6.508748	6.271669	0.0001690	0.0001690	1.2963485	TMEM185A	transmembrane protein 185A
TC01001498.hg.1	0.6964588	3.643448	6.265297	0.0001703	0.0001703	1.2889984	DNM3	dynamin 3
TC05000151.hg.1	-0.9174445	7.024338	-6.265137	0.0001703	0.0001703	1.2888141	RAI14	retinoic acid induced 14
TC03000846.hg.1	-1.7012340	7.307440	-6.633771	0.0001873	0.0001873	1.2801230	MME	membrane metallo-endopeptidase
TC0X001294.hg.1	0.7456987	3.471704	6.257240	0.0001718	0.0001718	1.2796966	PLS3-AS1	PLS3 antisense RNA 1
TC17000876.hg.1	0.7376908	4.445084	6.254919	0.0001723	0.0001723	1.2770144	SNORD1B	small nucleolar RNA, C/D box 1B
TC09000750.hg.1	1.0277154	4.652820	6.263155	0.0001762	0.0001762	1.2604377	SNORD62A	small nucleolar RNA, C/D box 62A
TC09000751.hg.1	1.0277154	4.652820	6.263155	0.0001762	0.0001762	1.2604377	SNORD62A	small nucleolar RNA, C/D box 62A
TC0X001544.hg.1	0.6766635	5.796061	6.235327	0.0001763	0.0001763	1.2543479	MPP1	membrane protein, palmitoylated 1, 55kDa
TC07001714.hg.1	-0.6385763	2.827722	-6.232660	0.0001768	0.0001768	1.2512592	FBXL13	F-box and leucine-rich repeat protein 13
TC12003272.hg.1	-0.8151441	3.611302	-6.231770	0.0001770	0.0001770	1.2502272	KLRC2	killer cell lectin-like receptor subfamily C, member 2
TC02000947.hg.1	-1.1302099	5.725787	-6.277302	0.0001796	0.0001796	1.2475454	KCNJ3	potassium inwardly-rectifying channel, subfamily J, member 3
TC03001038.hg.1	-0.7265613	5.595550	-6.228862	0.0001776	0.0001776	1.2468567	LPP	LIM domain containing preferred translocation partner in lipoma
TC19002518.hg.1	-0.7114854	6.856270	-6.217414	0.0001800	0.0001800	1.2335760	ERCC2	excision repair cross-complementation group 2
TC03002129.hg.1	0.7104320	3.525942	6.217308	0.0001800	0.0001800	1.2334536	LINC00887	long intergenic non-protein coding RNA 887
TC13000314.hg.1	-0.7574384	4.627012	-6.210627	0.0001814	0.0001814	1.2256937	SLITRK5	SLIT and NTRK-like family, member 5
TC03001883.hg.1	0.6983789	4.252960	6.207016	0.0001822	0.0001822	1.2214971	—	—
TC0X001273.hg.1	0.8825735	6.730987	6.196483	0.0001844	0.0001844	1.2092451	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
TC03002200.hg.1	-0.7961448	5.201192	-6.195698	0.0001846	0.0001846	1.2083315	—	—
TC0Y000165.hg.1	-0.8748908	5.838551	-6.194231	0.0001849	0.0001849	1.2066239	VCY	variable charge, Y-linked
TC13000597.hg.1	-0.9446576	6.964946	-6.189963	0.0001858	0.0001858	1.2016534	ELF1	E74-like factor 1 (ets domain transcription factor)
TC03000020.hg.1	-0.7820131	4.252809	-6.181169	0.0001878	0.0001878	1.1914037	AC069277.2	novel transcript
TC0X001318.hg.1	0.9638405	6.032737	6.189710	0.0001884	0.0001884	1.1903223	NKAP	NFKB activating protein
TC0X000114.hg.1	0.7837865	10.350480	6.177488	0.0001886	0.0001886	1.1871097	EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
TC03001014.hg.1	-0.7373236	4.751707	-6.175176	0.0001891	0.0001891	1.1844122	LOC344887	NmrA-like family domain containing 1 pseudogene
TC07001566.hg.1	-0.6869532	4.921720	-6.173533	0.0001895	0.0001895	1.1824936	SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
TC07002717.hg.1	0.9528963	8.145835	6.172005	0.0001898	0.0001898	1.1807104	—	—
TC10000672.hg.1	1.0016005	6.865673	6.158538	0.0001954	0.0001954	1.1540313	TBC1D12	TBC1 domain family, member 12
TC07000586.hg.1	-0.9245487	5.485823	-6.143932	0.0001976	0.0001976	1.1418256	FLJ30064	uncharacterized LOC644975
TC10001565.hg.1	1.0007763	6.609832	6.146701	0.0001981	0.0001981	1.1402119	—	—
TC15000025.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15000138.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15000149.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15000208.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001013.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001052.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001060.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001064.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001094.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001114.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001128.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC15001155.hg.1	0.7615376	4.212750	6.130263	0.0001993	0.0001993	1.1318488	—	—
TC07002501.hg.1	-0.7550658	6.241683	-6.129863	0.0001994	0.0001994	1.1313796	CUX1	cut-like homeobox 1
TC01005141.hg.1	1.1502596	2.415137	6.233645	0.0002058	0.0002058	1.1274386	CHRM3	cholinergic receptor, muscarinic 3
TC0X001397.hg.1	1.0689592	8.842757	6.140308	0.0002017	0.0002017	1.1245295	MOSPD1	motile sperm domain containing 1
TC02003360.hg.1	0.6490270	1.842433	6.117825	0.0002023	0.0002023	1.1172404	—	—
TC16001251.hg.1	1.0655057	5.615121	6.145842	0.0002042	0.0002042	1.1154956	SNORA70D	small nucleolar RNA, H/ACA box 70D
TC08000119.hg.1	0.6982650	6.829544	6.109448	0.0002043	0.0002043	1.1073881	TUSC3	tumor suppressor candidate 3
TC14001401.hg.1	0.8109898	1.643793	6.123206	0.0002053	0.0002053	1.1062340	—	—
TC17001291.hg.1	1.1102599	3.083679	6.170912	0.0002087	0.0002087	1.1029945	—	—
TC0X000589.hg.1	0.7170111	6.830329	6.105211	0.0002053	0.0002053	1.1024013	NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa
TC05000039.hg.1	-0.6912328	5.634455	-6.094776	0.0002078	0.0002078	1.0901082	ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif, 16
TC0X000410.hg.1	0.7381512	5.309880	6.093374	0.0002082	0.0002082	1.0884557	SLC16A2	solute carrier family 16, member 2 (thyroid hormone transporter)
TC13000103.hg.1	0.7616846	4.888970	6.088508	0.0002094	0.0002094	1.0827166	MEDAG	mesenteric estrogen-dependent adipogenesis
TC01005139.hg.1	0.7369315	3.472543	6.084622	0.0002103	0.0002103	1.0781316	CHRM3	cholinergic receptor, muscarinic 3
PSR01001663.hg.1	0.9552381	7.655919	6.081861	0.0002110	0.0002110	1.0748713	—	—
TC0X001907.hg.1	0.8503949	8.024684	6.080400	0.0002114	0.0002114	1.0731471	FMR1	fragile X mental retardation 1
TC0X001736.hg.1	-0.7178173	5.272288	-6.071677	0.0002136	0.0002136	1.0628405	—	—
TC14001474.hg.1	0.6564070	4.060877	6.065407	0.0002152	0.0002152	1.0554247	CLMN	calmin (calponin-like, transmembrane)
TC21000307.hg.1	-0.7952232	4.441969	-6.063938	0.0002155	0.0002155	1.0536866	LOC101927797	uncharacterized LOC101927797
TC08000209.hg.1	1.1044274	6.509641	6.092554	0.0002176	0.0002176	1.0522222	SCARA3	scavenger receptor class A, member 3
TC01004101.hg.1	-1.0020508	7.751588	-6.059070	0.0002187	0.0002187	1.0409687	—	—
TC14000012.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC14000018.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC14000864.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC14000867.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC22000447.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC22000452.hg.1	1.4436200	7.277551	6.221768	0.0002307	0.0002307	1.0319557	—	—
TC01002550.hg.1	0.6556209	2.537141	6.039073	0.0002220	0.0002220	1.0242168	—	—
TC14000356.hg.1	0.9597096	7.867261	6.038665	0.0002221	0.0002221	1.0237328	DAAM1	dishevelled associated activator of morphogenesis 1
TC21000715.hg.1	-0.7468572	2.757151	-6.031666	0.0002240	0.0002240	1.0154211	—	—
TC14001197.hg.1	1.7782682	5.032173	6.648934	0.0002604	0.0002604	1.0123198	HIF1A-AS2	HIF1A antisense RNA 2
TC20000072.hg.1	0.9756223	5.070100	6.043904	0.0002268	0.0002268	1.0079564	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)
PSR14014336.hg.1	0.7911003	8.710610	6.025366	0.0002256	0.0002256	1.0079321	—	—
TC0X000110.hg.1	0.7322409	8.172379	6.025305	0.0002257	0.0002257	1.0078598	PRDX4	peroxiredoxin 4
TC10001968.hg.1	1.2577859	2.417664	6.236817	0.0002401	0.0002401	1.0026547	—	—
TC04002625.hg.1	1.0292095	6.901829	6.022326	0.0002312	0.0002312	0.9874667	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
47419712_st	-1.0585112	2.766415	-6.064234	0.0002357	0.0002357	0.9813463	—	—
TC02000844.hg.1	-1.1285231	1.970427	-6.169315	0.0002423	0.0002423	0.9812736	—	—
TC10002812.hg.1	1.1914664	6.181228	6.080094	0.0002383	0.0002383	0.9757099	—	—
TC05000080.hg.1	-0.8354697	3.667167	-5.997291	0.0002333	0.0002333	0.9744921	LINC01194	long intergenic non-protein coding RNA 1194
TC13000109.hg.1	0.8464810	4.130427	5.997081	0.0002334	0.0002334	0.9742412	FRY	furry homolog (Drosophila)
TC18000436.hg.1	-0.7026978	5.878297	-5.994221	0.0002342	0.0002342	0.9708287	DSC2	desmocollin 2
TC17002817.hg.1	0.7839178	3.122982	5.993413	0.0002344	0.0002344	0.9698641	NPTX1	neuronal pentraxin I
TC07001563.hg.1	-0.7380321	4.520130	-5.991381	0.0002350	0.0002350	0.9674373	CACNA2D1	calcium channel, voltage-dependent, alpha 2/delta subunit 1
TC05002068.hg.1	0.6902950	5.321293	5.990685	0.0002352	0.0002352	0.9666067	LOC100268168	uncharacterized LOC100268168
TC08001440.hg.1	0.7697100	4.787639	5.983353	0.0002372	0.0002372	0.9578466	TP53INP1	tumor protein p53 inducible nuclear protein 1
TC04000905.hg.1	0.9395909	7.465035	5.982898	0.0002374	0.0002374	0.9573036	ANKRD37	ankyrin repeat domain 37
TC19001511.hg.1	0.6834756	5.930909	5.980994	0.0002379	0.0002379	0.9550274	FBXO27	F-box protein 27
TC09001709.hg.1	1.0472739	6.313993	6.005630	0.0002397	0.0002397	0.9545638	MIR3689F	microRNA 3689f
TC11002773.hg.1	0.9740720	6.248412	5.985844	0.0002400	0.0002400	0.9488917	FOLR1	folate receptor 1 (adult)
TC11003062.hg.1	1.1106659	7.124513	6.000363	0.0002417	0.0002417	0.9465742	LINC00958	long intergenic non-protein coding RNA 958
TC05003303.hg.1	0.8019173	6.969392	5.973740	0.0002400	0.0002400	0.9463500	PDGFRB	platelet-derived growth factor receptor, beta polypeptide
TC02000854.hg.1	-0.8412449	6.750887	-5.972882	0.0002402	0.0002402	0.9453233	LOC150776	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene
TC12000234.hg.1	1.1742593	10.152871	6.050979	0.0002466	0.0002466	0.9415564	SPX	spexin hormone
TC01004633.hg.1	-0.6744863	6.151033	-5.963645	0.0002429	0.0002429	0.9342623	—	—
TC14000225.hg.1	0.7701332	5.305737	5.962430	0.0002432	0.0002432	0.9328066	BRMS1L	breast cancer metastasis-suppressor 1-like
TC0X000636.hg.1	0.9141718	7.690635	5.961906	0.0002434	0.0002434	0.9321785	HPRT1	hypoxanthine phosphoribosyltransferase 1
TC01002424.hg.1	0.7367097	4.364754	5.954543	0.0002456	0.0002456	0.9233503	—	—
TC08000692.hg.1	-0.6757806	4.928793	-5.953868	0.0002458	0.0002458	0.9225406	SAMD12-AS1	SAMD12 antisense RNA 1
TC0X000604.hg.1	0.7325709	6.405853	5.952410	0.0002462	0.0002462	0.9207907	XIAP	X-linked inhibitor of apoptosis
TC0X000606.hg.1	0.8394651	7.693107	5.951965	0.0002463	0.0002463	0.9202571	STAG2	stromal antigen 2
TC07000371.hg.1	0.7696113	2.064403	5.952620	0.0002471	0.0002471	0.9179360	ZNF727P	zinc finger protein 727, pseudogene
TC11003000.hg.1	1.8568240	8.855866	6.488161	0.0002877	0.0002877	0.9034393	H19	H19, imprinted maternally expressed transcript (non-protein coding)
TC0X001400.hg.1	0.7500259	6.767142	5.934043	0.0002517	0.0002517	0.8987282	FAM127B	family with sequence similarity 127, member B
TC01006081.hg.1	0.8272347	7.263512	5.923528	0.0002549	0.0002549	0.8860746	—	—
TC0X000153.hg.1	-0.6861888	4.218175	-5.921680	0.0002554	0.0002554	0.8838492	—	—
TC10000475.hg.1	0.7442075	4.845581	5.919000	0.0002563	0.0002563	0.8806208	PLAU	plasminogen activator, urokinase
TC0X000724.hg.1	0.7267813	5.996204	5.917874	0.0002566	0.0002566	0.8792636	MTMR1	myotubularin related protein 1
TC20000945.hg.1	0.8081635	5.336384	5.912045	0.0002584	0.0002584	0.8722367	SALL4	spalt-like transcription factor 4
TC18000646.hg.1	-0.8291482	4.937844	-5.902493	0.0002614	0.0002614	0.8607118	ANKRD20A5P	ankyrin repeat domain 20 family, member A5, pseudogene
TC19001361.hg.1	0.7905959	3.247105	5.899885	0.0002622	0.0002622	0.8575624	ZNF99	zinc finger protein 99
TC16001511.hg.1	0.7271035	6.967735	5.889504	0.0002655	0.0002655	0.8450173	—	—
TC10000258.hg.1	-0.7447587	4.364083	-5.885748	0.0002667	0.0002667	0.8404742	RNU6-1118P	RNA, U6 small nuclear 1118, pseudogene
TC04001092.hg.1	-0.7749786	7.298407	-5.882042	0.0002679	0.0002679	0.8359899	SEL1L3	sel-1 suppressor of lin-12-like 3 (C. elegans)
TC0X000705.hg.1	0.8204962	7.538711	5.876917	0.0002696	0.0002696	0.8297853	FMR1	fragile X mental retardation 1
TC18000132.hg.1	1.0814345	4.707758	5.931848	0.0002752	0.0002752	0.8260680	RNF125	ring finger protein 125, E3 ubiquitin protein ligase
TC02001436.hg.1	-0.6369433	1.655180	-5.870067	0.0002719	0.0002719	0.8214853	AC019068.2	novel transcript, antisense to IQCA1
TC08001601.hg.1	0.6902170	5.931459	5.869722	0.0002720	0.0002720	0.8210666	TATDN1	TatD DNase domain containing 1
TC0X001559.hg.1	0.8352427	5.408787	5.865809	0.0002733	0.0002733	0.8163226	—	—
TC15001680.hg.1	0.9784335	4.564174	5.884935	0.0002769	0.0002769	0.8100998	—	—
TC04001152.hg.1	-0.7064261	4.720791	-5.856648	0.0002763	0.0002763	0.8052052	ATP8A1	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
TC05001087.hg.1	-0.8828340	4.389163	-5.864874	0.0002770	0.0002770	0.8051165	RNU6-705P	RNA, U6 small nuclear 705, pseudogene
TC17000975.hg.1	0.6855975	6.185292	5.853073	0.0002775	0.0002775	0.8008638	INPP5K	inositol polyphosphate-5-phosphatase K
TC03000732.hg.1	0.7204579	5.525181	5.850864	0.0002782	0.0002782	0.7981800	PPP2R3A	protein phosphatase 2, regulatory subunit B, alpha
TC0X002086.hg.1	0.6891633	6.288302	5.849710	0.0002786	0.0002786	0.7967780	XAGE-4	XAGE-4 protein
TC03000484.hg.1	-0.9739357	3.807517	-5.872314	0.0002810	0.0002810	0.7954637	OR5H14	olfactory receptor, family 5, subfamily H, member 14
TC17001177.hg.1	-0.7007895	7.146424	-5.845555	0.0002800	0.0002800	0.7917276	UPF3AP1	UPF3 regulator of nonsense transcripts homolog A (yeast) pseudogene 1
TC10001105.hg.1	0.7225352	3.645895	5.845434	0.0002801	0.0002801	0.7915809	C10orf67	chromosome 10 open reading frame 67
TC02002325.hg.1	0.9423300	4.215539	5.861549	0.0002815	0.0002815	0.7913801	—	—
47422459_st	0.6627519	2.024202	5.845163	0.0002802	0.0002802	0.7912508	—	—
TC11001616.hg.1	-0.7534237	2.196248	-5.838122	0.0002826	0.0002826	0.7826862	—	—
TC03003281.hg.1	0.6698170	3.298289	5.837426	0.0002828	0.0002828	0.7818383	—	—
TC07000635.hg.1	-0.7569982	5.852840	-5.836520	0.0002831	0.0002831	0.7807369	TRIP6	thyroid hormone receptor interactor 6
TC08000700.hg.1	1.2752697	5.049593	5.997083	0.0002977	0.0002977	0.7776036	COL14A1	collagen, type XIV, alpha 1
TC06001227.hg.1	0.8534338	3.619813	5.829436	0.0002866	0.0002866	0.7691125	LOC100507194	uncharacterized LOC100507194
TC05001608.hg.1	-0.7708535	5.225658	-5.822461	0.0002880	0.0002880	0.7636082	GLRX	glutaredoxin (thioltransferase)
TC14000403.hg.1	0.9128495	7.254727	5.821062	0.0002885	0.0002885	0.7619025	MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
TC0X002026.hg.1	-1.4342045	3.801925	-6.128821	0.0003177	0.0003177	0.7533333	DMD	dystrophin
TC0X000785.hg.1	0.6543537	6.349218	5.812407	0.0002916	0.0002916	0.7513421	—	—
TC11000679.hg.1	0.8883850	6.136355	5.811101	0.0002931	0.0002931	0.7467666	RHOD	ras homolog family member D
47419795_st	-0.8146498	1.575101	-5.821797	0.0002988	0.0002988	0.7339539	—	—
PSR19012462.hg.1	0.8719361	9.123132	5.796518	0.0002973	0.0002973	0.7319253	—	—
TC17_ctg5_hap1000017.hg.1	0.7365406	6.274967	5.784720	0.0003016	0.0003016	0.7174837	MAPT	microtubule-associated protein tau
TC10002947.hg.1	0.7897381	5.193458	5.784167	0.0003018	0.0003018	0.7168064	C10orf32	chromosome 10 open reading frame 32
TC17001158.hg.1	0.9268187	3.803957	5.795675	0.0003040	0.0003040	0.7135893	—	—
TC05000353.hg.1	1.0478810	6.120423	5.806282	0.0003076	0.0003076	0.7069173	—	—
PSR01001662.hg.1	0.8242455	8.061024	5.768617	0.0003076	0.0003076	0.6977376	—	—
TC14001732.hg.1	0.9145621	7.950138	5.766307	0.0003084	0.0003084	0.6949016	CHURC1	churchill domain containing 1
TC14001911.hg.1	0.8547923	9.612478	5.764844	0.0003090	0.0003090	0.6931053	RPPH1	ribonuclease P RNA component H1
TC10000619.hg.1	0.6752427	6.411792	5.764456	0.0003091	0.0003091	0.6926293	MINPP1	multiple inositol-polyphosphate phosphatase 1
TC02000219.hg.1	0.7148920	4.436599	5.763165	0.0003096	0.0003096	0.6910436	LTBP1	latent transforming growth factor beta binding protein 1
TC0X001257.hg.1	0.7206526	6.260345	5.755988	0.0003123	0.0003123	0.6822236	MORC4	MORC family CW-type zinc finger 4
TC03003338.hg.1	0.6400491	4.542909	5.755281	0.0003126	0.0003126	0.6813551	SATB1	SATB homeobox 1
TC03002199.hg.1	-0.7451216	3.178423	-5.743174	0.0003173	0.0003173	0.6664581	—	—
TC05000967.hg.1	-0.7507173	6.453194	-5.737630	0.0003195	0.0003195	0.6596303	CPEB4	cytoplasmic polyadenylation element binding protein 4
TC17000360.hg.1	0.7372584	2.642176	5.735294	0.0003204	0.0003204	0.6567511	LOC400590	uncharacterized LOC400590
TC11002370.hg.1	0.6571394	5.339894	5.726308	0.0003239	0.0003239	0.6456706	USP2	ubiquitin specific peptidase 2
TC08001138.hg.1	0.7072299	5.467354	5.725777	0.0003241	0.0003241	0.6450146	RAB11FIP1	RAB11 family interacting protein 1 (class I)
TC18000716.hg.1	0.8466208	6.274653	5.723053	0.0003252	0.0003252	0.6416529	—	—
TC0X001829.hg.1	0.8524501	3.541192	5.727801	0.0003259	0.0003259	0.6412010	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
TC14001023.hg.1	0.7009741	7.572328	5.722652	0.0003254	0.0003254	0.6411584	SPTSSA	serine palmitoyltransferase, small subunit A
TC02003584.hg.1	-0.8156757	6.983845	-5.721835	0.0003257	0.0003257	0.6401503	LOC150776	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene
TC0X000730.hg.1	0.7457626	6.557070	5.709762	0.0003306	0.0003306	0.6252338	VMA21	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
TC04001972.hg.1	-0.6141075	2.065625	-5.708519	0.0003311	0.0003311	0.6236975	—	—
3529035_st	0.8335144	9.844379	5.707725	0.0003314	0.0003314	0.6227148	—	—
TC0X002364.hg.1	-0.7948447	7.634491	-5.705393	0.0003324	0.0003324	0.6198309	PAGE2B	P antigen family, member 2B
TC0X000118.hg.1	0.9230232	6.441596	5.711341	0.0003339	0.0003339	0.6175733	PDK3	pyruvate dehydrogenase kinase, isozyme 3
TC03003399.hg.1	0.6635856	3.896523	5.701743	0.0003339	0.0003339	0.6153155	TRIM59	tripartite motif containing 59
TC13000863.hg.1	-0.7938279	3.352234	-5.701160	0.0003341	0.0003341	0.6145938	FAM155A	family with sequence similarity 155, member A
TC10000335.hg.1	0.6119068	5.054417	5.686803	0.0003401	0.0003401	0.5968088	—	—
TC10001283.hg.1	0.6119068	5.054417	5.686803	0.0003401	0.0003401	0.5968088	—	—
TC01003614.hg.1	0.8785811	6.295916	5.685678	0.0003418	0.0003418	0.5925462	NMNAT2	nicotinamide nucleotide adenylyltransferase 2
TC16001945.hg.1	0.7771377	5.344656	5.673560	0.0003457	0.0003457	0.5803767	MTSS1L	metastasis suppressor 1-like
TC04001213.hg.1	0.6776839	3.001834	5.670755	0.0003469	0.0003469	0.5768922	—	—
TC02003743.hg.1	-1.1180685	6.112414	-5.739021	0.0003550	0.0003550	0.5755642	COL3A1	collagen, type III, alpha 1
TC08000906.hg.1	0.8144103	4.644040	5.668938	0.0003477	0.0003477	0.5746348	DEFB1	defensin, beta 1
TC03000087.hg.1	-0.8296530	7.198337	-5.662858	0.0003503	0.0003503	0.5670772	SLC6A6	solute carrier family 6 (neurotransmitter transporter), member 6
47423846_st	0.6676991	1.295035	5.664980	0.0003517	0.0003517	0.5645221	—	—
TC0Y000093.hg.1	-0.8892819	3.194437	-5.671840	0.0003537	0.0003537	0.5615831	DAZ4	deleted in azoospermia 4
TC15000247.hg.1	-0.6243023	3.566108	-5.656454	0.0003531	0.0003531	0.5591107	—	—
TC11002242.hg.1	-0.6688801	4.967004	-5.652940	0.0003546	0.0003546	0.5547360	PDGFD	platelet derived growth factor D
TC12002769.hg.1	0.8894751	5.555599	5.658095	0.0003572	0.0003572	0.5503386	LRP6	low density lipoprotein receptor-related protein 6
TC03003028.hg.1	0.9301919	2.918578	5.669673	0.0003595	0.0003595	0.5480193	—	—
TC09002707.hg.1	0.7821696	5.059687	5.644963	0.0003581	0.0003581	0.5448002	—	—
TC06001977.hg.1	-0.8468154	5.770992	-5.643777	0.0003599	0.0003599	0.5404915	POPDC3	popeye domain containing 3
TC05002895.hg.1	-0.6552275	4.321251	-5.639809	0.0003604	0.0003604	0.5383753	—	—
TC02002481.hg.1	-0.9241447	5.175625	-5.651949	0.0003639	0.0003639	0.5339311	IFIH1	interferon induced with helicase C domain 1
TC10001094.hg.1	0.6656335	4.343407	5.634207	0.0003630	0.0003630	0.5313868	SKIDA1	SKI/DACH domain containing 1
TC18000331.hg.1	-0.7351874	1.623643	-5.640575	0.0003655	0.0003655	0.5274452	—	—
TC06002094.hg.1	0.5414286	1.883720	5.618044	0.0003703	0.0003703	0.5111979	RP1-86D1.2	novel transcript
TC11001123.hg.1	0.8585084	3.123799	5.624848	0.0003722	0.0003722	0.5090010	LINC01059	long intergenic non-protein coding RNA 1059
TC08002073.hg.1	-0.7241198	5.108187	-5.614399	0.0003720	0.0003720	0.5066388	SAMD12-AS1	SAMD12 antisense RNA 1
TC03002706.hg.1	-0.6717595	4.284527	-5.613570	0.0003724	0.0003724	0.5056026	LOC344887	NmrA-like family domain containing 1 pseudogene
TC0Y000210.hg.1	-0.6282956	2.986089	-5.610394	0.0003739	0.0003739	0.5016277	DAZ3	deleted in azoospermia 3
TC06000178.hg.1	0.8281427	6.003711	5.609954	0.0003741	0.0003741	0.5010774	HIST1H2BI	histone cluster 1, H2bi
TC05001366.hg.1	-0.7499833	9.734761	-5.608253	0.0003749	0.0003749	0.4989481	IL6ST	interleukin 6 signal transducer
TC01001877.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC01003862.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC06001206.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC07000287.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC07001403.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC07001413.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TCUn_gl000227000001.hg.1	-0.7639467	8.027964	-5.607042	0.0003754	0.0003754	0.4974323	—	—
TC03002564.hg.1	1.7388699	4.146516	6.204835	0.0004453	0.0004453	0.4970914	—	—
TC17001327.hg.1	-0.6405010	2.398019	-5.606370	0.0003757	0.0003757	0.4965910	—	—
TC0X001858.hg.1	0.8432949	6.875277	5.606053	0.0003759	0.0003759	0.4961940	XIAP	X-linked inhibitor of apoptosis
TC11000807.hg.1	0.7492423	7.634753	5.603498	0.0003771	0.0003771	0.4929938	SNORD15A	small nucleolar RNA, C/D box 15A
TC0X001073.hg.1	-0.6960524	2.802763	-5.603103	0.0003773	0.0003773	0.4924994	WNK3	WNK lysine deficient protein kinase 3
TC10000889.hg.1	0.9274532	6.951704	5.608862	0.0003790	0.0003790	0.4904044	HTRA1	HtrA serine peptidase 1
TC12001282.hg.1	0.7760214	5.788827	5.598427	0.0003795	0.0003795	0.4866402	EPS8	epidermal growth factor receptor pathway substrate 8
TC01001971.hg.1	0.8517096	2.546097	5.607306	0.0003845	0.0003845	0.4784679	RP11-80B9.1	putative novel transcript
TC01005947.hg.1	0.7333684	4.290926	5.589459	0.0003837	0.0003837	0.4753938	—	—
TC03002440.hg.1	0.7015642	8.534012	5.585657	0.0003856	0.0003856	0.4706227	TRMT10C	tRNA methyltransferase 10 homolog C (S. cerevisiae)
TC11000909.hg.1	0.5557228	2.361221	5.582334	0.0003872	0.0003872	0.4664512	—	—
TC6_dbb_hap3000062.hg.1	0.8612116	6.780695	5.581122	0.0003877	0.0003877	0.4649289	SNORA38	small nucleolar RNA, H/ACA box 38
TC6_mcf_hap5000057.hg.1	0.8612116	6.780695	5.581122	0.0003877	0.0003877	0.4649289	SNORA38	small nucleolar RNA, H/ACA box 38
TC07000370.hg.1	0.7395289	4.056102	5.573423	0.0003915	0.0003915	0.4552546	ZNF727P	zinc finger protein 727, pseudogene
TC21000165.hg.1	-0.5464614	2.233387	-5.570873	0.0003927	0.0003927	0.4520475	DSCR8	Down syndrome critical region gene 8
TC07000971.hg.1	0.6684399	5.963063	5.570729	0.0003928	0.0003928	0.4518674	RNY5	RNA, Ro-associated Y5
TC01003180.hg.1	0.8106220	5.773592	5.568358	0.0003940	0.0003940	0.4488843	—	—
TC14000608.hg.1	0.6792549	7.113754	5.560529	0.0003979	0.0003979	0.4390321	VRK1	vaccinia related kinase 1
TC0X001506.hg.1	0.6862783	6.537352	5.554918	0.0004007	0.0004007	0.4319642	CETN2	centrin, EF-hand protein, 2
TC0X000359.hg.1	0.6749175	4.733108	5.554457	0.0004009	0.0004009	0.4313834	—	—
TC04001650.hg.1	0.7255297	3.301368	5.554035	0.0004011	0.0004011	0.4308511	TMEM154	transmembrane protein 154
TC12000672.hg.1	0.6024904	2.845453	5.553197	0.0004015	0.0004015	0.4297953	ACSS3	acyl-CoA synthetase short-chain family member 3
TC01001668.hg.1	0.7776693	5.421759	5.550241	0.0004030	0.0004030	0.4260698	—	—
TC0X001175.hg.1	0.7109789	6.492865	5.549667	0.0004033	0.0004033	0.4253459	PGAM4	phosphoglycerate mutase family member 4
TC11001227.hg.1	-0.7500801	4.331568	-5.549198	0.0004035	0.0004035	0.4247546	RNU6-447P	RNA, U6 small nuclear 447, pseudogene
TC10000663.hg.1	0.5886895	4.851432	5.547703	0.0004043	0.0004043	0.4228686	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1
TC02002676.hg.1	-0.7386947	7.020906	-5.541796	0.0004073	0.0004073	0.4154169	TMEM237	transmembrane protein 237
TC0Y000182.hg.1	-0.7146034	6.544661	-5.538188	0.0004092	0.0004092	0.4108631	CD24	CD24 molecule
TC10001640.hg.1	0.6839552	4.696360	5.534979	0.0004108	0.0004108	0.4068098	MIR4482	microRNA 4482
TC0X001920.hg.1	0.6974432	8.321272	5.529836	0.0004135	0.0004135	0.4003126	CSAG3	CSAG family, member 3
TC03001982.hg.1	0.9162421	8.376353	5.533788	0.0004145	0.0004145	0.3993736	TERC	telomerase RNA component
TC01003327.hg.1	1.0639133	7.876971	5.553496	0.0004186	0.0004186	0.3969104	SCARNA4	small Cajal body-specific RNA 4
TC02002817.hg.1	0.5946271	1.920422	5.527071	0.0004149	0.0004149	0.3968168	—	—
TC06002626.hg.1	0.8665347	4.064591	5.535827	0.0004168	0.0004168	0.3955046	—	—
TC0X001058.hg.1	0.9110929	6.366984	5.530779	0.0004195	0.0004195	0.3891487	XAGE3	X antigen family, member 3
47419854_st	-0.7045740	1.124662	-5.531097	0.0004230	0.0004230	0.3825799	—	—
TC11002170.hg.1	0.7263199	6.601118	5.515759	0.0004208	0.0004208	0.3825056	FZD4	frizzled class receptor 4
TC0X000575.hg.1	0.8081668	7.879204	5.515564	0.0004209	0.0004209	0.3822584	IL13RA1	interleukin 13 receptor, alpha 1
TC02001089.hg.1	-0.7176387	7.499392	-5.512066	0.0004228	0.0004228	0.3778294	DNAJC10	DnaJ (Hsp40) homolog, subfamily C, member 10
TC0X000632.hg.1	0.5840082	2.912929	5.509249	0.0004243	0.0004243	0.3742602	—	—
TC02004657.hg.1	0.8621939	4.759356	5.512947	0.0004290	0.0004290	0.3665079	—	—
TC06000012.hg.1	-0.9985841	6.020653	-5.526581	0.0004335	0.0004335	0.3620198	FOXC1	forkhead box C1
TC0X000587.hg.1	0.8794622	6.833770	5.499911	0.0004320	0.0004320	0.3574375	UBE2A	ubiquitin-conjugating enzyme E2A
TC19002498.hg.1	-0.6055558	5.536909	-5.491171	0.0004341	0.0004341	0.3513306	—	—
TC0X001551.hg.1	-0.6298680	4.655588	-5.490931	0.0004342	0.0004342	0.3510249	CLIC2	chloride intracellular channel 2
TC01002608.hg.1	0.6582133	4.953412	5.477537	0.0004416	0.0004416	0.3340039	TESK2	testis-specific kinase 2
TC17002241.hg.1	0.8492909	7.270161	5.476265	0.0004423	0.0004423	0.3323855	MAPT	microtubule-associated protein tau
TC11002922.hg.1	0.6131255	3.301357	5.468586	0.0004466	0.0004466	0.3226122	LINC01059	long intergenic non-protein coding RNA 1059
TC18000647.hg.1	-0.7354574	3.792214	-5.466857	0.0004476	0.0004476	0.3204100	—	—
TC09000988.hg.1	0.6647022	5.467409	5.460720	0.0004511	0.0004511	0.3125918	MOB3B	MOB kinase activator 3B
TC01001040.hg.1	1.2319692	6.362590	5.593313	0.0004724	0.0004724	0.3115257	HSD3B1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
TC11002293.hg.1	1.0058443	7.592295	5.479415	0.0004550	0.0004550	0.3109899	IL18	interleukin 18
TC10002793.hg.1	0.9561467	5.670729	5.480994	0.0004563	0.0004563	0.3091126	—	—
TC13000901.hg.1	-0.6300362	5.104132	-5.450448	0.0004570	0.0004570	0.2994916	RASA3	RAS p21 protein activator 3
TC14000990.hg.1	-0.6262461	3.107868	-5.447358	0.0004588	0.0004588	0.2955482	LOC728755	uncharacterized LOC728755
TC15002684.hg.1	0.7046313	2.478935	5.439135	0.0004636	0.0004636	0.2850460	—	—
TC0X000967.hg.1	0.9431532	3.381133	5.464821	0.0004681	0.0004681	0.2845114	—	—
TC21000840.hg.1	-0.7683999	3.762091	-5.438083	0.0004642	0.0004642	0.2837016	LOC101927797	uncharacterized LOC101927797
TC03003123.hg.1	0.8375514	4.195385	5.438265	0.0004695	0.0004695	0.2748609	—	—
TC17001066.hg.1	0.6946825	8.493863	5.422156	0.0004737	0.0004737	0.2633266	MED31	mediator complex subunit 31
TC01000819.hg.1	0.7324324	3.535035	5.417904	0.0004763	0.0004763	0.2578817	—	—
TC0X002221.hg.1	0.7597310	2.532791	5.417554	0.0004799	0.0004799	0.2517285	—	—
TC07000159.hg.1	-0.7650620	6.655345	-5.407704	0.0004825	0.0004825	0.2448050	NFE2L3	nuclear factor, erythroid 2-like 3
TC16001784.hg.1	0.6694674	6.360683	5.407689	0.0004825	0.0004825	0.2447870	ABCC6P2	ATP-binding cassette, sub-family C, member 6 pseudogene 2
TC01000224.hg.1	0.7989266	6.573278	5.400298	0.0004870	0.0004870	0.2353015	—	—
TC10000724.hg.1	0.6516568	6.056236	5.400038	0.0004872	0.0004872	0.2349681	HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor
TC11001395.hg.1	0.9376150	4.949716	5.423744	0.0004922	0.0004922	0.2335122	NRIP3	nuclear receptor interacting protein 3
TC02002544.hg.1	-0.6052675	5.272063	-5.398904	0.0004879	0.0004879	0.2335116	CHN1	chimerin 1
TC6_cox_hap2000237.hg.1	-0.6676686	8.263919	-5.397979	0.0004885	0.0004885	0.2323237	HLA-B	major histocompatibility complex, class I, B
TC06001828.hg.1	-0.6862935	7.079144	-5.395740	0.0004899	0.0004899	0.2294484	DST	dystonin
TC11002078.hg.1	0.7281609	2.249280	5.398520	0.0004911	0.0004911	0.2282633	P4HA3	prolyl 4-hydroxylase, alpha polypeptide III
TC03002720.hg.1	-0.7772174	6.325408	-5.394550	0.0004906	0.0004906	0.2279194	LPP	LIM domain containing preferred translocation partner in lipoma
TC01006113.hg.1	0.9398440	4.205474	5.417769	0.0004965	0.0004965	0.2250994	—	—
TC19001986.hg.1	0.7598166	4.991221	5.392319	0.0004920	0.0004920	0.2250535	—	—
TC14001022.hg.1	0.5890417	4.985109	5.384329	0.0004971	0.0004971	0.2147798	EGLN3	egl-9 family hypoxia-inducible factor 3
TC16001863.hg.1	0.7710411	7.040219	5.381881	0.0004986	0.0004986	0.2116310	—	—
TC17002500.hg.1	0.6837284	5.460707	5.378754	0.0005006	0.0005006	0.2076069	LOC100506974	uncharacterized LOC100506974
TC14001714.hg.1	0.9183229	7.963681	5.385350	0.0005019	0.0005019	0.2074569	DAAM1	dishevelled associated activator of morphogenesis 1
TC06002092.hg.1	0.7560262	7.096785	5.376295	0.0005022	0.0005022	0.2044406	PTPRK	protein tyrosine phosphatase, receptor type, K
TC14000426.hg.1	0.9964945	5.996742	5.411287	0.0005097	0.0005097	0.2026747	TTC9	tetratricopeptide repeat domain 9
TC01001140.hg.1	0.8490349	7.817939	5.373743	0.0005038	0.0005038	0.2011550	—	—
TC02002712.hg.1	-0.6916628	6.136942	-5.372125	0.0005049	0.0005049	0.1990701	METTL21A	methyltransferase like 21A
TC11000214.hg.1	-0.8378396	4.271236	-5.379616	0.0005064	0.0005064	0.1988566	PDE3B	phosphodiesterase 3B, cGMP-inhibited
TC01000892.hg.1	0.9014716	5.317816	5.388071	0.0005104	0.0005104	0.1949707	PALMD	palmdelphin
TC05000066.hg.1	0.6440668	5.966930	5.358911	0.0005135	0.0005135	0.1820353	SNHG18	small nucleolar RNA host gene 18 (non-protein coding)
TC11003418.hg.1	0.5918190	3.212986	5.358435	0.0005138	0.0005138	0.1814203	—	—
TC01000979.hg.1	0.7986232	7.337973	5.355019	0.0005160	0.0005160	0.1770119	RAP1A	RAP1A, member of RAS oncogene family
TC0X000596.hg.1	0.5623979	4.539209	5.354376	0.0005165	0.0005165	0.1761816	MCTS1	malignant T cell amplified sequence 1
TC0X000055.hg.1	0.9578837	2.792203	5.404829	0.0005261	0.0005261	0.1759097	LINC01203	long intergenic non-protein coding RNA 1203
TC16000156.hg.1	1.0935470	3.789330	5.440579	0.0005335	0.0005335	0.1748730	—	—
47424755_st	-0.7114325	1.996115	-5.358305	0.0005195	0.0005195	0.1726968	—	—
TC18000833.hg.1	0.7562220	3.433449	5.350493	0.0005190	0.0005190	0.1711683	PIEZO2	piezo-type mechanosensitive ion channel component 2
TC12000984.hg.1	1.0422987	5.264021	5.416744	0.0005322	0.0005322	0.1701792	LOC100293704	uncharacterized LOC100293704
TC02003902.hg.1	0.6210616	3.586011	5.348010	0.0005207	0.0005207	0.1679599	—	—
TC10000306.hg.1	0.6901682	6.449374	5.344828	0.0005228	0.0005228	0.1638481	FAM35DP	family with sequence similarity 35, member A pseudogene
TC06001084.hg.1	0.7373748	4.756558	5.344010	0.0005234	0.0005234	0.1627910	—	—
TC19000979.hg.1	-0.6687797	8.929180	-5.343450	0.0005237	0.0005237	0.1620673	—	—
TC01000124.hg.1	0.6916176	5.198565	5.342926	0.0005241	0.0005241	0.1613899	RBP7	retinol binding protein 7, cellular
TC05003005.hg.1	-0.7745326	9.337272	-5.339765	0.0005262	0.0005262	0.1573026	—	—
TC08001238.hg.1	0.7106105	9.165480	5.338532	0.0005270	0.0005270	0.1557079	IMPAD1	inositol monophosphatase domain containing 1
TC02000898.hg.1	-0.8238332	2.459136	-5.347378	0.0005375	0.0005375	0.1428691	AC016710.1	putative novel transcript
TC17000517.hg.1	-0.8320055	5.592047	-5.335131	0.0005351	0.0005351	0.1428228	FKBP10	FK506 binding protein 10, 65 kDa
TC02003533.hg.1	0.7236022	3.367379	5.327832	0.0005343	0.0005343	0.1418606	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
TC14000799.hg.1	0.6178481	8.562997	5.326991	0.0005349	0.0005349	0.1407709	MARK3	MAP/microtubule affinity-regulating kinase 3
TC18000205.hg.1	0.8609328	7.481749	5.328377	0.0005357	0.0005357	0.1400207	MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1
TC04001370.hg.1	0.7005052	6.508777	5.322284	0.0005381	0.0005381	0.1346725	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
TC03000021.hg.1	-0.6163470	5.260091	-5.314642	0.0005435	0.0005435	0.1247640	AC069277.2	novel transcript
TC05002512.hg.1	-0.7872648	5.857405	-5.307254	0.0005486	0.0005486	0.1151767	NR2F1	nuclear receptor subfamily 2, group F, member 1
TC18000020.hg.1	0.9869290	5.951157	5.343735	0.0005565	0.0005565	0.1145857	DLGAP1-AS1	DLGAP1 antisense RNA 1
47419719_st	-0.5840350	1.549251	-5.306380	0.0005493	0.0005493	0.1140427	—	—
TC02001145.hg.1	0.6954518	8.083083	5.304984	0.0005503	0.0005503	0.1122298	—	—
TC10000128.hg.1	0.6555990	5.321170	5.303183	0.0005515	0.0005515	0.1098909	—	—
TC19000513.hg.1	0.6853716	5.459882	5.302357	0.0005521	0.0005521	0.1088174	LOC101927667	uncharacterized LOC101927667
TC01002016.hg.1	0.6989255	6.560262	5.300773	0.0005532	0.0005532	0.1067599	OR2W3	olfactory receptor, family 2, subfamily W, member 3
TC03003025.hg.1	0.9000907	4.584460	5.316387	0.0005601	0.0005601	0.1016292	—	—
TC15001667.hg.1	-0.6165590	6.435312	-5.294775	0.0005575	0.0005575	0.0989640	PTPN9	protein tyrosine phosphatase, non-receptor type 9
TC09001337.hg.1	0.5791611	2.484722	5.291730	0.0005597	0.0005597	0.0950035	ECM2	extracellular matrix protein 2, female organ and adipocyte specific
TC05002725.hg.1	0.6294269	6.070769	5.291399	0.0005600	0.0005600	0.0945739	—	—
TC0X001602.hg.1	0.7610058	2.871887	5.294301	0.0005612	0.0005612	0.0937043	—	—
TC06001397.hg.1	0.7103869	7.235290	5.287027	0.0005631	0.0005631	0.0888852	—	—
TC11000122.hg.1	-0.4644551	1.556454	-5.286555	0.0005635	0.0005635	0.0882708	OR56A3	olfactory receptor, family 56, subfamily A, member 3
TC03001717.hg.1	-0.7502700	7.596744	-5.283932	0.0005654	0.0005654	0.0848569	ITGB5	integrin, beta 5
TC07000648.hg.1	-0.9113738	4.489562	-5.302995	0.0005723	0.0005723	0.0809136	LOC101927746	uncharacterized LOC101927746
PSR01001658.hg.1	0.6654783	10.212725	5.275710	0.0005714	0.0005714	0.0741468	—	—
TC05001731.hg.1	0.5530430	4.192829	5.273906	0.0005727	0.0005727	0.0717961	ZNF608	zinc finger protein 608
TC04002255.hg.1	0.7036668	3.265877	5.272536	0.0005738	0.0005738	0.0700104	EDNRA	endothelin receptor type A
TC17001759.hg.1	0.7201885	6.403408	5.268394	0.0005768	0.0005768	0.0646094	WFDC21P	WAP four-disulfide core domain 21, pseudogene
TC0X000001.hg.1	0.6277918	5.437922	5.267831	0.0005773	0.0005773	0.0638745	PLCXD1	phosphatidylinositol-specific phospholipase C, X domain containing 1
TC04000636.hg.1	-0.6613867	4.717581	-5.257159	0.0005853	0.0005853	0.0499451	FAT4	FAT atypical cadherin 4
TC14001140.hg.1	0.7874722	5.741637	5.255751	0.0005882	0.0005882	0.0456260	TXNDC16	thioredoxin domain containing 16
TC02000221.hg.1	0.7145629	4.074858	5.252957	0.0005885	0.0005885	0.0444561	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
TC11002097.hg.1	0.7922125	5.747282	5.251801	0.0005923	0.0005923	0.0390003	—	—
TC14001024.hg.1	0.8788883	7.506283	5.254841	0.0005933	0.0005933	0.0386725	EAPP	E2F-associated phosphoprotein
TC0Y000083.hg.1	-0.8010626	3.005257	-5.256297	0.0005938	0.0005938	0.0383905	DAZ2	deleted in azoospermia 2
TC17001820.hg.1	-0.7315648	5.551324	-5.246011	0.0005938	0.0005938	0.0353752	SLC16A6	solute carrier family 16, member 6
TC18000800.hg.1	0.5549191	3.975459	5.244098	0.0005953	0.0005953	0.0328740	LINC00470	long intergenic non-protein coding RNA 470
TC04001494.hg.1	-0.5906526	5.524718	-5.242996	0.0005961	0.0005961	0.0314321	PRSS12	protease, serine, 12 (neurotrypsin, motopsin)
TC19000198.hg.1	0.6621185	4.728078	5.241151	0.0005975	0.0005975	0.0290185	—	—
TC10000668.hg.1	0.8296061	3.909111	5.249749	0.0006010	0.0006010	0.0271047	LGI1	leucine-rich, glioma inactivated 1
TC01004738.hg.1	0.6019783	3.202356	5.239024	0.0005992	0.0005992	0.0262336	—	—
TC6_mcf_hap5000195.hg.1	-0.6406582	8.483195	-5.235658	0.0006018	0.0006018	0.0218270	HLA-B	major histocompatibility complex, class I, B
TC03001641.hg.1	0.7553867	5.490657	5.235059	0.0006023	0.0006023	0.0210436	LOC151760	uncharacterized LOC151760
TC12000778.hg.1	0.7908048	3.106620	5.239013	0.0006055	0.0006055	0.0180217	NR1H4	nuclear receptor subfamily 1, group H, member 4
TC02002827.hg.1	-0.6321462	5.917383	-5.230956	0.0006055	0.0006055	0.0156687	DOCK10	dedicator of cytokinesis 10
TC0X001486.hg.1	0.6588392	6.713237	5.228249	0.0006076	0.0006076	0.0121217	CD99L2	CD99 molecule-like 2
TC13001676.hg.1	-0.9432500	4.272248	-5.260848	0.0006188	0.0006188	0.0075538	—	—
3598709_st	0.6187015	9.998298	5.223153	0.0006116	0.0006116	0.0054421	—	—
TC10000245.hg.1	-0.6536246	2.384165	-5.223095	0.0006117	0.0006117	0.0053649	ANKRD30A	ankyrin repeat domain 30A
TC6_qbl_hap6000147.hg.1	-0.6395249	8.788937	-5.222520	0.0006121	0.0006121	0.0046116	HLA-B	major histocompatibility complex, class I, B
TC05001151.hg.1	0.6092430	7.581184	5.221834	0.0006127	0.0006127	0.0037111	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
TC01002706.hg.1	0.6890495	6.112406	5.219006	0.0006149	0.0006149	0.0000017	TACSTD2	tumor-associated calcium signal transducer 2
TC0X001595.hg.1	0.7672191	4.659661	5.219733	0.0006163	0.0006163	-0.0014925	—	—
TC14001493.hg.1	-0.6120831	8.547519	-5.217813	0.0006159	0.0006159	-0.0015630	—	—
TC05003094.hg.1	-1.0078990	6.530065	-5.257292	0.0006262	0.0006262	-0.0027526	—	—
TC04002962.hg.1	0.5781896	6.209980	5.212534	0.0006201	0.0006201	-0.0084931	LOC285431	uncharacterized LOC285431
TC19000162.hg.1	0.7367929	6.495348	5.210103	0.0006221	0.0006221	-0.0116848	—	—
TC11000542.hg.1	0.6665994	6.343644	5.208089	0.0006237	0.0006237	-0.0143309	FADS2	fatty acid desaturase 2
TC03000384.hg.1	0.7889773	6.666680	5.207720	0.0006240	0.0006240	-0.0148149	PTPRG	protein tyrosine phosphatase, receptor type, G
TC14000446.hg.1	0.5470269	3.425840	5.207205	0.0006244	0.0006244	-0.0154919	ACOT4	acyl-CoA thioesterase 4
TC14001730.hg.1	0.6901177	4.295980	5.202657	0.0006282	0.0006282	-0.0214693	AKAP5	A kinase (PRKA) anchor protein 5
TC02004804.hg.1	-0.7893012	7.108441	-5.202372	0.0006284	0.0006284	-0.0218434	—	—
TC03001949.hg.1	-1.1383591	4.850063	-5.326800	0.0006659	0.0006659	-0.0305188	RARRES1	retinoic acid receptor responder (tazarotene induced) 1
TC03002433.hg.1	0.6822117	3.409662	5.193922	0.0006353	0.0006353	-0.0329572	—	—
TC20001446.hg.1	-0.7244498	7.980515	-5.191094	0.0006377	0.0006377	-0.0366793	RRBP1	ribosome binding protein 1
TC17000592.hg.1	0.6463233	6.506526	5.184236	0.0006434	0.0006434	-0.0457105	MAPT	microtubule-associated protein tau
TC10000168.hg.1	0.7767713	6.874958	5.180620	0.0006465	0.0006465	-0.0504751	OTUD1	OTU deubiquitinase 1
TC02001437.hg.1	0.6166395	4.459649	5.179958	0.0006470	0.0006470	-0.0513477	ACKR3	atypical chemokine receptor 3
TC11002154.hg.1	0.8762333	4.804917	5.193891	0.0006548	0.0006548	-0.0563910	SNORA70E	small nucleolar RNA, H/ACA box 70E
TC05001607.hg.1	0.5947892	4.831048	5.175378	0.0006509	0.0006509	-0.0573865	CTD-2154I11.2	novel transcript
TC14000311.hg.1	0.7147424	3.385972	5.172745	0.0006531	0.0006531	-0.0608598	—	—
TC07000286.hg.1	-0.6336289	9.752643	-5.165092	0.0006597	0.0006597	-0.0709591	LOC100132062	uncharacterized LOC100132062
TC07001383.hg.1	-0.6336289	9.752643	-5.165092	0.0006597	0.0006597	-0.0709591	—	—
TC07001414.hg.1	-0.6336289	9.752643	-5.165092	0.0006597	0.0006597	-0.0709591	—	—
TC14002098.hg.1	0.8563942	8.721627	5.170567	0.0006618	0.0006618	-0.0717249	—	—
TC0X001624.hg.1	1.0471810	8.714992	5.204072	0.0006746	0.0006746	-0.0764691	SAT1	spermidine/spermine N1-acetyltransferase 1
TC17002290.hg.1	0.7621442	4.620652	5.162837	0.0006654	0.0006654	-0.0783047	DGKE	diacylglycerol kinase, epsilon 64kDa
TC13000634.hg.1	0.7248776	5.447627	5.158095	0.0006658	0.0006658	-0.0802023	SLC25A30	solute carrier family 25, member 30
TC01000238.hg.1	0.6091658	4.610547	5.157546	0.0006662	0.0006662	-0.0809283	ACTL8	actin-like 8
TC04001373.hg.1	-0.7379384	5.645879	-5.156081	0.0006675	0.0006675	-0.0828643	PPM1K	protein phosphatase, Mg2+/Mn2+ dependent, 1K
47424241_st	0.6538743	1.765563	5.158857	0.0006689	0.0006689	-0.0836121	—	—
TC04001809.hg.1	1.0003508	8.231300	5.175498	0.0006765	0.0006765	-0.0872818	ACSL1	acyl-CoA synthetase long-chain family member 1
TC03001758.hg.1	0.5623526	5.034141	5.152272	0.0006708	0.0006708	-0.0879006	—	—
TC07002014.hg.1	0.7782728	6.937948	5.151740	0.0006713	0.0006713	-0.0886033	ACTR3C	ARP3 actin-related protein 3 homolog C (yeast)
TC08002074.hg.1	-0.7293042	2.772174	-5.153389	0.0006719	0.0006719	-0.0888103	—	—
TC04000140.hg.1	-0.9786822	6.885337	-5.175503	0.0006785	0.0006785	-0.0896152	CPEB2	cytoplasmic polyadenylation element binding protein 2
47423997_st	1.2010572	4.014232	5.330311	0.0007205	0.0007205	-0.0909003	—	—
2978682_st	-0.7388333	8.306940	-5.149686	0.0006731	0.0006731	-0.0913202	—	—
TC19000605.hg.1	-0.5514775	5.445699	-5.149486	0.0006733	0.0006733	-0.0915845	CD177	CD177 molecule
TC07001898.hg.1	-0.6466726	6.146293	-5.148243	0.0006744	0.0006744	-0.0932286	CREB3L2	cAMP responsive element binding protein 3-like 2
TC17002688.hg.1	0.9415915	6.107696	5.171684	0.0006819	0.0006819	-0.0946069	—	—
TC07000838.hg.1	0.9891004	6.412695	5.184799	0.0006870	0.0006870	-0.0964511	CALD1	caldesmon 1
TC06000518.hg.1	0.8362916	3.636428	5.158130	0.0006800	0.0006800	-0.0966580	—	—
TC07003080.hg.1	-0.7064316	7.768495	-5.141045	0.0006808	0.0006808	-0.1027567	TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TC14001806.hg.1	0.7825342	4.946989	5.144296	0.0006848	0.0006848	-0.1063654	FOXN3-AS1	FOXN3 antisense RNA 1
TC17001153.hg.1	0.5773511	5.551710	5.136860	0.0006845	0.0006845	-0.1082993	LOC100506974	uncharacterized LOC100506974
TC0X002337.hg.1	0.7890351	7.738152	5.135591	0.0006857	0.0006857	-0.1099810	ACSL4	acyl-CoA synthetase long-chain family member 4
TC13000804.hg.1	0.5863023	3.440432	5.134468	0.0006867	0.0006867	-0.1114689	DZIP1	DAZ interacting zinc finger protein 1
TC17000380.hg.1	0.6633460	5.977935	5.129895	0.0006908	0.0006908	-0.1175301	TMEM98	transmembrane protein 98
TC14001992.hg.1	0.9721756	8.068775	5.146541	0.0006982	0.0006982	-0.1206328	MIS18BP1	MIS18 binding protein 1
TC01005538.hg.1	-0.5832777	3.580644	-5.119635	0.0007002	0.0007002	-0.1311419	—	—
TC14000211.hg.1	0.5661983	5.543937	5.119577	0.0007002	0.0007002	-0.1312188	NPAS3	neuronal PAS domain protein 3
TC22001089.hg.1	-0.6164826	6.580692	-5.116472	0.0007031	0.0007031	-0.1353410	HMOX1	heme oxygenase (decycling) 1
TC07003116.hg.1	-0.6513655	5.557781	-5.114705	0.0007047	0.0007047	-0.1376886	LINC00998	long intergenic non-protein coding RNA 998
TC07001907.hg.1	-0.5887193	6.829489	-5.112976	0.0007063	0.0007063	-0.1399856	KIAA1549	KIAA1549
TC14000837.hg.1	0.6633601	6.378671	5.111936	0.0007073	0.0007073	-0.1413675	CRIP2	cysteine-rich protein 2
TC14000402.hg.1	0.6797017	3.017379	5.108986	0.0007100	0.0007100	-0.1452873	FAM71D	family with sequence similarity 71, member D
TC16001498.hg.1	-0.9251286	5.090527	-5.137153	0.0007253	0.0007253	-0.1530057	—	—
TC10000412.hg.1	0.7235325	6.390597	5.102029	0.0007166	0.0007166	-0.1545380	DDX50	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
TC03002462.hg.1	0.6155631	5.411748	5.100514	0.0007180	0.0007180	-0.1565532	—	—
TC10000385.hg.1	0.6942844	7.190667	5.099986	0.0007185	0.0007185	-0.1572554	NRBF2	nuclear receptor binding factor 2
TC09001708.hg.1	0.7332620	5.281230	5.098429	0.0007200	0.0007200	-0.1593276	MIR3689D2	microRNA 3689d-2
TC11000394.hg.1	0.6985036	5.076780	5.096868	0.0007214	0.0007214	-0.1614053	CREB3L1	cAMP responsive element binding protein 3-like 1
3482865_st	0.6820300	10.011925	5.090621	0.0007274	0.0007274	-0.1697233	—	—
TC12000809.hg.1	0.6493347	3.872660	5.087667	0.0007302	0.0007302	-0.1736593	—	—
TC0X001392.hg.1	0.8590592	5.218080	5.102981	0.0007369	0.0007369	-0.1758747	MIR503HG	MIR503 host gene (non-protein coding)
TC0X000622.hg.1	0.6364891	5.163315	5.081724	0.0007360	0.0007360	-0.1815809	SLC25A14	solute carrier family 25 (mitochondrial carrier, brain), member 14
TC03001192.hg.1	-0.6896871	4.851413	-5.078081	0.0007395	0.0007395	-0.1864393	WNT7A	wingless-type MMTV integration site family, member 7A
TC06003522.hg.1	0.6690922	3.074953	5.071765	0.0007457	0.0007457	-0.1948681	—	—
TC0X000990.hg.1	0.8073161	5.584393	5.076655	0.0007511	0.0007511	-0.1988433	LINC01186	long intergenic non-protein coding RNA 1186
47422095_st	-0.8046093	2.104830	-5.096506	0.0007589	0.0007589	-0.2006050	—	—
TC15001525.hg.1	-0.7952926	2.219535	-5.086530	0.0007577	0.0007577	-0.2025515	—	—
TC03003362.hg.1	0.7082512	7.608201	5.063733	0.0007537	0.0007537	-0.2055942	PHLDB2	pleckstrin homology-like domain, family B, member 2
PSR06024774.hg.1	1.4894432	3.486136	5.477716	0.0008914	0.0008914	-0.2164215	—	—
TC06001057.hg.1	-0.5855813	7.117793	-5.054108	0.0007633	0.0007633	-0.2184635	STX11	syntaxin 11
TC10000715.hg.1	-0.9356017	7.909624	-5.066708	0.0007727	0.0007727	-0.2239094	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
TC02001606.hg.1	0.6283805	2.922660	5.049232	0.0007682	0.0007682	-0.2249877	—	—
TC12001749.hg.1	0.7566669	4.958803	5.052656	0.0007697	0.0007697	-0.2253949	—	—
TC04001277.hg.1	-0.6192314	4.773080	-5.048854	0.0007686	0.0007686	-0.2254931	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif, 3
TC01003154.hg.1	0.5833689	6.480385	5.045462	0.0007721	0.0007721	-0.2300352	—	—
TC22000333.hg.1	0.4967633	1.510931	5.043572	0.0007740	0.0007740	-0.2325661	RNU6-375P	RNA, U6 small nuclear 375, pseudogene
TC01006263.hg.1	0.7883230	4.760299	5.050047	0.0007778	0.0007778	-0.2342891	—	—
TC14001317.hg.1	0.6730073	6.746058	5.042145	0.0007755	0.0007755	-0.2344773	NEK9	NIMA-related kinase 9
TC01002943.hg.1	-0.6024620	4.050226	-5.042140	0.0007755	0.0007755	-0.2344843	NBPF6	neuroblastoma breakpoint family, member 6
TC08000109.hg.1	-0.5707581	3.181648	-5.041887	0.0007758	0.0007758	-0.2348229	KIAA1456	KIAA1456
TC14001680.hg.1	0.6538216	6.205862	5.040186	0.0007775	0.0007775	-0.2371018	ATP5S	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
TC0X000878.hg.1	1.0583068	2.834279	5.155543	0.0008169	0.0008169	-0.2392402	ACE2	angiotensin I converting enzyme 2
TC16001270.hg.1	-0.6522616	5.725757	-5.038458	0.0007793	0.0007793	-0.2394174	MLKL	mixed lineage kinase domain-like
TC01000733.hg.1	0.6045480	3.345947	5.037667	0.0007801	0.0007801	-0.2404779	PDE4B	phosphodiesterase 4B, cAMP-specific
TC08000809.hg.1	-0.7833161	6.453269	-5.038889	0.0007812	0.0007812	-0.2411244	LY6K	lymphocyte antigen 6 complex, locus K
TC02000434.hg.1	0.5652115	1.792045	5.034685	0.0007832	0.0007832	-0.2444756	—	—
TC14000489.hg.1	0.6289084	5.680216	5.034341	0.0007835	0.0007835	-0.2449358	GSTZ1	glutathione S-transferase zeta 1
TC10002051.hg.1	0.8319226	3.457078	5.050496	0.0007889	0.0007889	-0.2450386	—	—
TC0X000948.hg.1	-0.6691147	5.112170	-5.025081	0.0007932	0.0007932	-0.2573592	TMEM47	transmembrane protein 47
TC03001744.hg.1	0.7136430	6.073006	5.023953	0.0007944	0.0007944	-0.2588726	TXNRD3NB	thioredoxin reductase 3 neighbor
TC03001941.hg.1	0.9207833	5.395689	5.058885	0.0008065	0.0008065	-0.2592982	VEPH1	ventricular zone expressed PH domain-containing 1
TC6_ssto_hap7000191.hg.1	-0.6214737	8.078286	-5.019746	0.0007989	0.0007989	-0.2645222	HLA-B	major histocompatibility complex, class I, B
TC01003401.hg.1	0.6864886	3.790625	5.018422	0.0008003	0.0008003	-0.2663005	—	—
TC19001323.hg.1	-0.5630133	2.724575	-5.017595	0.0008011	0.0008011	-0.2674111	—	—
TC6_mann_hap4000188.hg.1	-0.6201457	7.909742	-5.015511	0.0008034	0.0008034	-0.2702113	HLA-B	major histocompatibility complex, class I, B
TC08001013.hg.1	0.8365167	5.111761	5.030895	0.0008095	0.0008095	-0.2711325	MTUS1	microtubule associated tumor suppressor 1
TC16001225.hg.1	-0.5648859	9.598256	-5.014470	0.0008045	0.0008045	-0.2716104	NQO1	NAD(P)H dehydrogenase, quinone 1
TC09001996.hg.1	0.8467053	3.932819	5.019842	0.0008218	0.0008218	-0.2862753	TJP2	tight junction protein 2
TC01003533.hg.1	0.8320544	9.207836	5.008820	0.0008197	0.0008197	-0.2877936	SNORD78	small nucleolar RNA, C/D box 78
TC09002683.hg.1	0.5533844	2.081326	5.000752	0.0008193	0.0008193	-0.2900605	RP11-23B15.1	putative novel transcript
TC0X002208.hg.1	0.8036994	6.547705	5.006216	0.0008213	0.0008213	-0.2902084	RNF113A	ring finger protein 113A
TC01004391.hg.1	0.4565989	1.616289	4.997737	0.0008226	0.0008226	-0.2941193	RP4-705F19.1	novel transcript
TC10001564.hg.1	0.5782175	6.087878	4.996587	0.0008238	0.0008238	-0.2956675	—	—
TC01000632.hg.1	1.2167779	4.508725	5.205952	0.0009021	0.0009021	-0.3006902	RP4-657D16.3	novel transcript, antisense to NRD1
TC01001142.hg.1	0.6193510	8.239760	4.991386	0.0008296	0.0008296	-0.3026740	RNVU1-14	RNA, variant U1 small nuclear 14
TC0X002232.hg.1	0.6615738	5.245464	4.991346	0.0008296	0.0008296	-0.3027273	—	—
TC0X002191.hg.1	0.6030801	3.459670	4.989939	0.0008312	0.0008312	-0.3046245	PLS3-AS1	PLS3 antisense RNA 1
TC06002124.hg.1	1.0626799	3.792849	5.092788	0.0008690	0.0008690	-0.3060579	SLC2A12	solute carrier family 2 (facilitated glucose transporter), member 12
TC11003280.hg.1	0.6711367	2.751955	4.980795	0.0008413	0.0008413	-0.3169536	—	—
TC0X000526.hg.1	0.7048002	10.441019	4.980747	0.0008414	0.0008414	-0.3170193	PRPS1	phosphoribosyl pyrophosphate synthetase 1
TC0X001097.hg.1	-0.6006062	6.213870	-4.978852	0.0008435	0.0008435	-0.3195751	ZC4H2	zinc finger, C4H2 domain containing
TC04002902.hg.1	0.5490834	2.768621	4.976067	0.0008467	0.0008467	-0.3233347	—	—
PSR06002931.hg.1	-0.5492844	10.255977	-4.971211	0.0008522	0.0008522	-0.3298908	—	—
TC08000814.hg.1	-0.7327763	7.401557	-4.970709	0.0008527	0.0008527	-0.3305697	LY6E	lymphocyte antigen 6 complex, locus E
TC12003061.hg.1	-0.6916045	7.915190	-4.970705	0.0008527	0.0008527	-0.3305742	—	—
TC02000840.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC14000015.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC14000021.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC14000022.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC14000865.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC15001019.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC15001033.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC22000449.hg.1	1.0995778	6.905576	5.043392	0.0008801	0.0008801	-0.3313276	—	—
TC14001076.hg.1	0.8637916	4.201069	4.985919	0.0008665	0.0008665	-0.3378254	—	—
TC01001461.hg.1	0.6261074	7.629964	4.961455	0.0008633	0.0008633	-0.3430759	MPZL1	myelin protein zero-like 1
TC15000989.hg.1	-0.8079192	2.677866	-4.977807	0.0008711	0.0008711	-0.3445348	—	—
TC03001455.hg.1	0.7210319	8.846838	4.958597	0.0008666	0.0008666	-0.3469400	TNNC1	troponin C type 1 (slow)
TC03000768.hg.1	0.8131327	6.515891	4.960932	0.0008735	0.0008735	-0.3522068	PLS1	plastin 1
TC10002313.hg.1	-0.5799767	3.479205	-4.953876	0.0008721	0.0008721	-0.3533272	RP11-328K15.1	putative novel transcript
TC08000595.hg.1	0.6909977	2.682240	4.955505	0.0008727	0.0008727	-0.3533332	—	—
TC01001591.hg.1	0.5565538	4.958564	4.953268	0.0008728	0.0008728	-0.3541503	C1orf21	chromosome 1 open reading frame 21
TC09002054.hg.1	0.5230688	1.660053	4.952273	0.0008740	0.0008740	-0.3554978	—	—
TC14001348.hg.1	0.6883587	9.466758	4.952270	0.0008740	0.0008740	-0.3555014	SPTLC2	serine palmitoyltransferase, long chain base subunit 2
TC06004060.hg.1	-0.5946694	8.598116	-4.947392	0.0008797	0.0008797	-0.3621068	HLA-B	major histocompatibility complex, class I, B
TC01000704.hg.1	0.7368042	4.872713	4.950862	0.0008811	0.0008811	-0.3621976	RNU6-414P	RNA, U6 small nuclear 414, pseudogene
47419404_st	-0.9087644	1.443607	-5.087927	0.0009343	0.0009343	-0.3632429	—	—
TC02004490.hg.1	0.7196999	6.513889	4.945977	0.0008814	0.0008814	-0.3640233	—	—
TC07001026.hg.1	0.7315145	4.415417	4.947930	0.0008837	0.0008837	-0.3653931	FABP5P3	fatty acid binding protein 5 pseudogene 3
TC05000569.hg.1	-0.5806194	5.098688	-4.944415	0.0008832	0.0008832	-0.3661393	PRR16	proline rich 16
TC10001314.hg.1	0.6357383	4.247743	4.937308	0.0008917	0.0008917	-0.3757721	FAM13C	family with sequence similarity 13, member C
TC12001252.hg.1	0.6727828	5.207881	4.937113	0.0008919	0.0008919	-0.3760354	RNU6-1295P	RNA, U6 small nuclear 1295, pseudogene
TC08000256.hg.1	0.6021554	3.641269	4.933539	0.0008962	0.0008962	-0.3808837	RP11-11N9.4	novel transcript
TC06004063.hg.1	0.6841308	4.636236	4.933171	0.0008966	0.0008966	-0.3813828	HIST1H2AI	histone cluster 1, H2ai
TC10002387.hg.1	0.8978310	4.229988	4.968089	0.0009103	0.0009103	-0.3814458	—	—
TC19000870.hg.1	0.7296863	6.556600	4.932897	0.0008970	0.0008970	-0.3817541	CACNG6	calcium channel, voltage-dependent, gamma subunit 6
TC11000876.hg.1	0.5782934	6.053303	4.931033	0.0008992	0.0008992	-0.3842826	PRSS23	protease, serine, 23
TC11001704.hg.1	-0.7382266	1.914391	-4.948157	0.0009075	0.0009075	-0.3856447	—	—
TC02002509.hg.1	0.9235019	7.543060	4.942823	0.0009100	0.0009100	-0.3895103	LRP2	low density lipoprotein receptor-related protein 2
TC14001085.hg.1	0.7724045	7.153534	4.926572	0.0009046	0.0009046	-0.3903370	MIS18BP1	MIS18 binding protein 1
TC19001358.hg.1	1.1887577	6.465393	5.073887	0.0009633	0.0009633	-0.3910172	ZNF676	zinc finger protein 676
TC13000364.hg.1	-0.6881694	6.707978	-4.924733	0.0009068	0.0009068	-0.3928348	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
2828012_st	0.8022333	9.350040	4.928970	0.0009103	0.0009103	-0.3943521	—	—
TC19000506.hg.1	0.9382088	5.742515	4.961178	0.0009301	0.0009301	-0.4001522	LOC728485	uncharacterized LOC728485
TC6_mcf_hap5000121.hg.1	-0.6337377	8.374273	-4.917669	0.0009155	0.0009155	-0.4024302	FLOT1	flotillin 1
TC09001527.hg.1	0.6350070	3.706197	4.917644	0.0009155	0.0009155	-0.4024649	SNORA70C	small nucleolar RNA, H/ACA box 70C
TC09000268.hg.1	0.6675843	5.469776	4.917036	0.0009162	0.0009162	-0.4032907	—	—
TC04001783.hg.1	0.5247730	5.089133	4.916391	0.0009170	0.0009170	-0.4041667	MGC45800	uncharacterized LOC90768
TC0X001589.hg.1	-0.6502007	5.783244	-4.914467	0.0009194	0.0009194	-0.4067824	VCX3B	variable charge, X-linked 3B
TC15001335.hg.1	0.7029949	5.387848	4.912574	0.0009218	0.0009218	-0.4093568	FBN1	fibrillin 1
TC12000290.hg.1	0.5450523	5.667772	4.912452	0.0009219	0.0009219	-0.4095220	RNU6-618P	RNA, U6 small nuclear 618, pseudogene
TC15001464.hg.1	0.6061691	7.983791	4.911976	0.0009225	0.0009225	-0.4101696	RSL24D1	ribosomal L24 domain containing 1
TC11000808.hg.1	0.8277241	9.626641	4.920412	0.0009274	0.0009274	-0.4114123	SNORD15B	small nucleolar RNA, C/D box 15B
TC02000293.hg.1	0.5910257	3.215326	4.908904	0.0009263	0.0009263	-0.4143483	EPCAM	epithelial cell adhesion molecule
TC10000680.hg.1	0.6862562	5.256222	4.908556	0.0009267	0.0009267	-0.4148215	RNU6-271P	RNA, U6 small nuclear 271, pseudogene
TC0X000017.hg.1	0.6623484	7.247725	4.908193	0.0009272	0.0009272	-0.4153150	GYG2	glycogenin 2
TC15001553.hg.1	-0.7765921	6.346126	-4.911218	0.0009322	0.0009322	-0.4184172	RBPMS2	RNA binding protein with multiple splicing 2
TC06003523.hg.1	0.8467704	2.815810	4.933405	0.0009434	0.0009434	-0.4201302	—	—
TC13001366.hg.1	0.8384969	4.494882	4.920113	0.0009414	0.0009414	-0.4228872	LINC00415	putative novel transcript
TC18000621.hg.1	0.5246464	3.482521	4.899670	0.0009379	0.0009379	-0.4269165	—	—
TC0X001575.hg.1	0.8442549	4.498288	4.913877	0.0009505	0.0009505	-0.4323312	—	—
TC15002232.hg.1	0.5695644	4.218051	4.895111	0.0009436	0.0009436	-0.4331267	TLN2	talin 2
TC14002040.hg.1	1.5486401	6.052807	5.310278	0.0011152	0.0011152	-0.4341970	HIF1A-AS2	HIF1A antisense RNA 2
TC16001783.hg.1	0.6100141	5.647462	4.889993	0.0009502	0.0009502	-0.4401011	—	—
TC01002452.hg.1	0.5586972	4.196841	4.887206	0.0009537	0.0009537	-0.4439017	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
TC10001361.hg.1	0.7154466	8.456033	4.884514	0.0009572	0.0009572	-0.4475735	SAR1A	secretion associated, Ras related GTPase 1A
TC02001118.hg.1	-0.6257814	6.429404	-4.884446	0.0009573	0.0009573	-0.4476658	INPP1	inositol polyphosphate-1-phosphatase
TC04001442.hg.1	1.1121808	2.570639	5.073336	0.0010392	0.0010392	-0.4492306	LOC101929491	uncharacterized LOC101929491
TC10002646.hg.1	0.5723258	3.741198	4.882309	0.0009600	0.0009600	-0.4505814	PRKG1-AS1	PRKG1 antisense RNA 1
TC03001981.hg.1	0.5559920	4.665670	4.880650	0.0009622	0.0009622	-0.4528450	RNU6-637P	RNA, U6 small nuclear 637, pseudogene
TC02002678.hg.1	-0.8039210	6.024864	-4.888859	0.0009674	0.0009674	-0.4541908	ALS2	amyotrophic lateral sclerosis 2 (juvenile)
TC02005007.hg.1	-0.6457065	6.887333	-4.879238	0.0009640	0.0009640	-0.4547731	C2orf47	chromosome 2 open reading frame 47
TC18000457.hg.1	0.5901557	7.028564	4.878522	0.0009650	0.0009650	-0.4557491	RPRD1A	regulation of nuclear pre-mRNA domain containing 1A
TC11003482.hg.1	-0.6173052	6.699021	-4.877293	0.0009666	0.0009666	-0.4574272	SLC43A3	solute carrier family 43, member 3
TC09002305.hg.1	0.6420709	4.764491	4.876859	0.0009671	0.0009671	-0.4580206	AIF1L	allograft inflammatory factor 1-like
TC17001353.hg.1	0.5989497	6.874724	4.871822	0.0009737	0.0009737	-0.4648992	MYO1D	myosin ID
TC17000879.hg.1	0.6187288	7.300900	4.870802	0.0009751	0.0009751	-0.4662927	METTL23	methyltransferase like 23
TC10002673.hg.1	0.9902507	7.545245	4.904255	0.0009942	0.0009942	-0.4697819	JMJD1C	jumonji domain containing 1C
TC06001260.hg.1	-0.6320393	6.507523	-4.867894	0.0009789	0.0009789	-0.4702665	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TC06003069.hg.1	-0.8141609	3.794299	-4.879580	0.0009901	0.0009901	-0.4749739	MYB	v-myb avian myeloblastosis viral oncogene homolog
TC07002493.hg.1	-0.6190576	3.933603	-4.863298	0.0009850	0.0009850	-0.4765496	MUC3A	mucin 3A, cell surface associated
TC11000733.hg.1	0.5596095	5.880984	4.863096	0.0009852	0.0009852	-0.4768261	—	—
TC07000753.hg.1	0.5852869	2.120355	4.862451	0.0009861	0.0009861	-0.4777079	RNU6-102P	RNA, U6 small nuclear 102, pseudogene
TC18000505.hg.1	0.5949354	8.950815	4.861649	0.0009872	0.0009872	-0.4788055	SNORD58A	small nucleolar RNA, C/D box 58A
TC20000840.hg.1	0.6000774	10.360787	4.859375	0.0009902	0.0009902	-0.4819153	SNORA71C	small nucleolar RNA, H/ACA box 71C
TC6_cox_hap2000100.hg.1	1.0943826	2.665726	5.030106	0.0010679	0.0010679	-0.4834808	HCG24	HLA complex group 24
TC0X002204.hg.1	1.0056276	7.002256	4.901538	0.0010197	0.0010197	-0.4899553	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
TC12000283.hg.1	-0.5834340	4.428380	-4.852843	0.0009990	0.0009990	-0.4908547	LINC00941	long intergenic non-protein coding RNA 941
TC13000918.hg.1	-0.7146864	8.756166	-4.852289	0.0009997	0.0009997	-0.4916134	—	—
2909166_st	-0.7928903	7.891154	-4.853538	0.0010008	0.0010008	-0.4920210	—	—
TC08001554.hg.1	0.5723942	2.369615	4.851793	0.0010004	0.0010004	-0.4922919	RP11-4K16.2	novel transcript
TC13000484.hg.1	-0.5798690	6.348465	-4.851321	0.0010010	0.0010010	-0.4929386	MIPEP	mitochondrial intermediate peptidase
TC12003284.hg.1	0.7790339	6.337812	4.856141	0.0010038	0.0010038	-0.4933923	RHOF	ras homolog family member F (in filopodia)
TC19001589.hg.1	-0.8095839	7.539800	-4.854895	0.0010055	0.0010055	-0.4950937	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1
TC04000212.hg.1	-0.6588723	5.578946	-4.838589	0.0010184	0.0010184	-0.5103850	C4orf19	chromosome 4 open reading frame 19
TC17002377.hg.1	0.6531369	7.467968	4.837691	0.0010197	0.0010197	-0.5116163	METTL23	methyltransferase like 23
TC18000280.hg.1	0.5140193	3.531502	4.836500	0.0010213	0.0010213	-0.5132495	LINC00470	long intergenic non-protein coding RNA 470
TC10001410.hg.1	0.6085394	5.685246	4.828182	0.0010329	0.0010329	-0.5246642	PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme
TC10000044.hg.1	-0.6129947	2.850058	-4.827801	0.0010334	0.0010334	-0.5251876	AKR1C4	aldo-keto reductase family 1, member C4
TC06001248.hg.1	0.5457989	4.355952	4.827378	0.0010340	0.0010340	-0.5257690	—	—
TC10000484.hg.1	0.5753111	6.676256	4.827294	0.0010341	0.0010341	-0.5258836	SAMD8	sterile alpha motif domain containing 8
TC10000809.hg.1	0.7094650	7.847117	4.826889	0.0010347	0.0010347	-0.5264402	SHOC2	soc-2 suppressor of clear homolog (C. elegans)
TC02004772.hg.1	-0.6955644	5.775760	-4.825688	0.0010364	0.0010364	-0.5280887	TYW5	tRNA-yW synthesizing protein 5
TC06002848.hg.1	-0.6424994	8.924007	-4.823447	0.0010395	0.0010395	-0.5311667	PTP4A1	protein tyrosine phosphatase type IVA, member 1
TC17001289.hg.1	2.1576325	3.085936	5.708796	0.0014483	0.0014483	-0.5359793	—	—
TC06003053.hg.1	0.4876507	1.703345	4.815335	0.0010510	0.0010510	-0.5423148	—	—
TC04000274.hg.1	-0.6147284	6.941056	-4.813815	0.0010532	0.0010532	-0.5444053	ATP10D	ATPase, class V, type 10D
TC10001390.hg.1	1.2704909	2.168655	5.180392	0.0012310	0.0012310	-0.5465048	—	—
TC0X000784.hg.1	0.7181603	7.316793	4.808574	0.0010607	0.0010607	-0.5516133	VBP1	von Hippel-Lindau binding protein 1
TC0X000740.hg.1	0.5902713	7.397473	4.808078	0.0010615	0.0010615	-0.5522968	MAGEA2	melanoma antigen family A, 2
TC07002117.hg.1	0.5302491	5.082952	4.806924	0.0010631	0.0010631	-0.5538850	—	—
TC19002060.hg.1	0.6143617	11.200733	4.803634	0.0010679	0.0010679	-0.5584125	—	—
TC07000365.hg.1	-0.6267272	6.752957	-4.801423	0.0010711	0.0010711	-0.5614581	—	—
TC07001382.hg.1	-0.6267272	6.752957	-4.801423	0.0010711	0.0010711	-0.5614581	—	—
TC07001424.hg.1	-0.6267272	6.752957	-4.801423	0.0010711	0.0010711	-0.5614581	—	—
TC13000749.hg.1	-0.7689457	9.322928	-4.803903	0.0010749	0.0010749	-0.5632635	RP11-318G21.4	putative novel transcript
TC08000602.hg.1	-0.6520993	7.395703	-4.796730	0.0010779	0.0010779	-0.5679219	POP1	processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
TC0X000112.hg.1	0.9365541	6.598943	4.830524	0.0010964	0.0010964	-0.5690641	SAT1	spermidine/spermine N1-acetyltransferase 1
TC01001007.hg.1	0.7242080	5.055562	4.800490	0.0010823	0.0010823	-0.5696290	—	—
TC11001628.hg.1	-0.7093760	1.414059	-4.826296	0.0010985	0.0010985	-0.5719308	—	—
TC04001765.hg.1	-0.6700129	6.450245	-4.792829	0.0010837	0.0010837	-0.5732974	VEGFC	vascular endothelial growth factor C
TC12000252.hg.1	0.5075615	4.882016	4.791142	0.0010862	0.0010862	-0.5756237	LYRM5	LYR motif containing 5
TC11000754.hg.1	0.5242111	5.762865	4.790110	0.0010877	0.0010877	-0.5770463	FOLR1	folate receptor 1 (adult)
TC03001149.hg.1	0.5986344	5.344740	4.790074	0.0010877	0.0010877	-0.5770949	CAMK1	calcium/calmodulin-dependent protein kinase I
TC14001293.hg.1	0.7102748	3.670798	4.791961	0.0010904	0.0010904	-0.5783028	—	—
TC11001528.hg.1	0.6039683	4.613181	4.788881	0.0010895	0.0010895	-0.5787401	PAX6	paired box 6
TC08000260.hg.1	0.7412925	6.978915	4.788299	0.0010904	0.0010904	-0.5795434	—	—
TC08002263.hg.1	0.5678774	8.844662	4.787886	0.0010910	0.0010910	-0.5801123	CLU	clusterin
TC18000608.hg.1	1.0122759	6.560055	4.841587	0.0011193	0.0011193	-0.5809072	—	—
TC18000459.hg.1	0.6372647	4.404199	4.784724	0.0010957	0.0010957	-0.5844742	—	—
TC17000992.hg.1	0.8059898	7.530698	4.788182	0.0011005	0.0011005	-0.5865548	SNORD91B	small nucleolar RNA, C/D box 91B
TC03002106.hg.1	1.0722415	4.972510	4.904441	0.0011653	0.0011653	-0.5902771	LEPREL1	leprecan-like 1
TC19002342.hg.1	0.5783236	10.978747	4.780145	0.0011026	0.0011026	-0.5907932	—	—
TC03001992.hg.1	0.6539348	4.055988	4.777914	0.0011059	0.0011059	-0.5938725	RP11-373E16.4	novel transcript
TC10002613.hg.1	0.6420621	4.228124	4.777143	0.0011071	0.0011071	-0.5949371	—	—
TC01003878.hg.1	-0.6920736	4.217955	-4.774729	0.0011116	0.0011116	-0.5988639	RNU6-1319P	RNA, U6 small nuclear 1319, pseudogene
TC01004037.hg.1	-0.6920736	4.217955	-4.774729	0.0011116	0.0011116	-0.5988639	RNU6-747P	RNA, U6 small nuclear 747, pseudogene
TC07000284.hg.1	-0.6920736	4.217955	-4.774729	0.0011116	0.0011116	-0.5988639	RNU6-241P	RNA, U6 small nuclear 241, pseudogene
TC11003086.hg.1	0.6395122	5.378599	4.772369	0.0011143	0.0011143	-0.6015308	RPL36AP40	ribosomal protein L36a pseudogene 40
TC11001108.hg.1	0.5293939	4.420183	4.764716	0.0011260	0.0011260	-0.6121082	RNU6-256P	RNA, U6 small nuclear 256, pseudogene
TC09000687.hg.1	0.5526874	9.096762	4.760100	0.0011331	0.0011331	-0.6184933	TMSB4XP4	thymosin beta 4, X-linked pseudogene 4
TC03002900.hg.1	0.5448980	4.151586	4.759724	0.0011337	0.0011337	-0.6190128	ARIH2	ariadne RBR E3 ubiquitin protein ligase 2
TC05003356.hg.1	0.6424091	5.332247	4.757475	0.0011372	0.0011372	-0.6221247	LOC100268168	uncharacterized LOC100268168
TC19002325.hg.1	0.9376258	3.388403	4.807906	0.0011703	0.0011703	-0.6261044	—	—
TC0X001935.hg.1	0.5282492	10.932080	4.754508	0.0011418	0.0011418	-0.6262316	—	—
TC10001092.hg.1	0.5672172	7.012108	4.753833	0.0011428	0.0011428	-0.6271663	CASC10	cancer susceptibility candidate 10
TC02000237.hg.1	0.5318914	5.218370	4.753636	0.0011431	0.0011431	-0.6274384	QPCT	glutaminyl-peptide cyclotransferase
TC08001612.hg.1	-1.6446445	3.636100	-5.268387	0.0014159	0.0014159	-0.6283572	—	—
TC15001635.hg.1	0.6204349	5.541237	4.752864	0.0011444	0.0011444	-0.6285079	C15orf59	chromosome 15 open reading frame 59
TC01002338.hg.1	-0.7715970	6.302254	-4.758371	0.0011475	0.0011475	-0.6286197	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
TC05000541.hg.1	-0.5713527	4.711656	-4.751010	0.0011473	0.0011473	-0.6310748	KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
TC10000449.hg.1	0.8411674	7.113461	4.759435	0.0011554	0.0011554	-0.6334478	DDIT4	DNA-damage-inducible transcript 4
TC08000997.hg.1	0.5335907	5.496680	4.748657	0.0011510	0.0011510	-0.6343344	LONRF1	LON peptidase N-terminal domain and ring finger 1
TC0X000188.hg.1	-0.5662248	6.098042	-4.748406	0.0011513	0.0011513	-0.6346816	—	—
TC19002531.hg.1	-0.5777170	8.166668	-4.747675	0.0011525	0.0011525	-0.6356951	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
TC12003271.hg.1	-0.7244437	4.061267	-4.751872	0.0011562	0.0011562	-0.6366241	KLRC3	killer cell lectin-like receptor subfamily C, member 3
TC11002706.hg.1	0.6880041	7.854921	4.746803	0.0011539	0.0011539	-0.6369031	—	—
TC08002397.hg.1	0.6254606	2.947448	4.742467	0.0011607	0.0011607	-0.6429113	ZNF704	zinc finger protein 704
TC04002223.hg.1	-0.5278175	1.711800	-4.741269	0.0011626	0.0011626	-0.6445717	—	—
TC07000364.hg.1	-0.6692827	8.962738	-4.741001	0.0011631	0.0011631	-0.6449444	LINC01061	long intergenic non-protein coding RNA 1061
TC07001425.hg.1	-0.6692827	8.962738	-4.741001	0.0011631	0.0011631	-0.6449444	—	—
TC19000977.hg.1	-0.6692827	8.962738	-4.741001	0.0011631	0.0011631	-0.6449444	—	—
TC02003765.hg.1	-0.8542709	7.478946	-4.748269	0.0011737	0.0011737	-0.6492119	—	—
TC05001168.hg.1	-0.5579754	6.341798	-4.736505	0.0011702	0.0011702	-0.6511784	RP11-308B16.2	putative novel transcript
TC0X000586.hg.1	0.5560105	9.133272	4.730617	0.0011797	0.0011797	-0.6593482	SLC25A5	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
TC0X001311.hg.1	0.6636734	5.952274	4.725802	0.0011875	0.0011875	-0.6660335	NKRF	NFKB repressing factor
TC01002206.hg.1	0.5619783	7.838157	4.724731	0.0011893	0.0011893	-0.6675213	RNU5E-4P	RNA, U5E small nuclear 4, pseudogene
TC0Y000329.hg.1	0.5938078	4.557931	4.724278	0.0011900	0.0011900	-0.6681507	—	—
TC02001167.hg.1	0.6364738	9.032162	4.724166	0.0011902	0.0011902	-0.6683059	RNU6-31P	RNA, U6 small nuclear 31, pseudogene
TC10002322.hg.1	0.5599647	8.625060	4.720945	0.0011954	0.0011954	-0.6727808	FAM45B	family with sequence similarity 45, member A pseudogene
TC08001467.hg.1	0.7647261	7.151279	4.723495	0.0011971	0.0011971	-0.6728863	RP11-410L14.2	novel transcript
TC17001271.hg.1	0.6435159	3.773692	4.720493	0.0011962	0.0011962	-0.6734079	—	—
TC07001111.hg.1	0.5191973	3.202899	4.714050	0.0012068	0.0012068	-0.6823651	—	—
TC0X002096.hg.1	-0.6392916	8.441876	-4.712335	0.0012096	0.0012096	-0.6847493	ZC4H2	zinc finger, C4H2 domain containing
TC17000793.hg.1	0.6433446	6.962723	4.711882	0.0012104	0.0012104	-0.6853794	—	—
TC06000492.hg.1	-0.6219247	4.180071	-4.710864	0.0012121	0.0012121	-0.6867965	—	—
TC10000470.hg.1	0.5157442	5.881570	4.710022	0.0012135	0.0012135	-0.6879667	CHCHD1	coiled-coil-helix-coiled-coil-helix domain containing 1
TC16002072.hg.1	-0.5403044	6.329252	-4.710001	0.0012135	0.0012135	-0.6879966	SRCAP	Snf2-related CREBBP activator protein
PSR02004963.hg.1	0.6690421	1.637010	4.722899	0.0012233	0.0012233	-0.6893840	—	—
TC14000362.hg.1	0.5179564	6.273173	4.707940	0.0012170	0.0012170	-0.6908638	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A
TC08000472.hg.1	0.4951272	1.551792	4.707893	0.0012170	0.0012170	-0.6909287	—	—
TC01001207.hg.1	0.7254943	4.212524	4.710763	0.0012233	0.0012233	-0.6937652	RP11-126K1.8	putative novel transcript
47423226_st	0.5881306	1.129937	4.712142	0.0012303	0.0012303	-0.6975033	—	—
TC06003643.hg.1	-0.5150378	3.388920	-4.701469	0.0012278	0.0012278	-0.6998711	ADCY10P1	soluble adenylyl cyclase (SAC) pseudogene
TC07000724.hg.1	-0.5135646	4.846412	-4.700608	0.0012293	0.0012293	-0.7010706	ST7	suppression of tumorigenicity 7
TC20000903.hg.1	0.5341256	4.683956	4.698888	0.0012322	0.0012322	-0.7034657	ZNF334	zinc finger protein 334
TC01002055.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-1100P	RNA, U6 small nuclear 1100, pseudogene
TC01003865.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-791P	RNA, U6 small nuclear 791, pseudogene
TC04001502.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-1217P	RNA, U6 small nuclear 1217, pseudogene
TC09000858.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-785P	RNA, U6 small nuclear 785, pseudogene
TC16000715.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-355P	RNA, U6 small nuclear 355, pseudogene
TC19000980.hg.1	-0.7271427	4.352752	-4.703051	0.0012375	0.0012375	-0.7052154	RNU6-1076P	RNA, U6 small nuclear 1076, pseudogene
TC11001431.hg.1	0.8844800	7.853288	4.711131	0.0012436	0.0012436	-0.7059438	LINC00958	long intergenic non-protein coding RNA 958
TC10000657.hg.1	0.5829406	6.787484	4.694543	0.0012396	0.0012396	-0.7095201	MARCH5	membrane-associated ring finger (C3HC4) 5
TC16000208.hg.1	0.6547248	4.039921	4.694503	0.0012396	0.0012396	-0.7095760	RNU6-1340P	RNA, U6 small nuclear 1340, pseudogene
TC11001429.hg.1	0.5674973	3.822162	4.690306	0.0012468	0.0012468	-0.7154257	—	—
TC09001332.hg.1	0.5939710	7.020176	4.690010	0.0012473	0.0012473	-0.7158386	SNORA84	small nucleolar RNA, H/ACA box 84
TC0Y000109.hg.1	0.6307309	8.614817	4.689808	0.0012477	0.0012477	-0.7161204	VAMP7	vesicle-associated membrane protein 7
TC10001589.hg.1	0.7770659	7.500796	4.693179	0.0012522	0.0012522	-0.7176435	SNORA12	small nucleolar RNA, H/ACA box 12
TC03001570.hg.1	-0.6360833	5.953290	-4.686966	0.0012525	0.0012525	-0.7200838	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
TC11002541.hg.1	0.5644871	6.556997	4.686895	0.0012527	0.0012527	-0.7201820	—	—
TC03000770.hg.1	0.7947121	5.528883	4.698832	0.0012641	0.0012641	-0.7226551	TRPC1	transient receptor potential cation channel, subfamily C, member 1
TC17001290.hg.1	0.8392879	4.447596	4.709396	0.0012734	0.0012734	-0.7243373	—	—
TC02002541.hg.1	-0.5116087	3.461423	-4.678971	0.0012664	0.0012664	-0.7312383	WIPF1	WAS/WASL interacting protein family, member 1
PSR02034038.hg.1	0.7573834	7.100916	4.678852	0.0012728	0.0012728	-0.7350283	—	—
TC12001857.hg.1	0.6865289	4.369743	4.676197	0.0012746	0.0012746	-0.7370723	SLC9A7P1	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 pseudogene 1
TC12003029.hg.1	0.6865289	4.369743	4.676197	0.0012746	0.0012746	-0.7370723	SLC9A7P1	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 pseudogene 1
TC01002023.hg.1	0.6058614	6.866387	4.672393	0.0012779	0.0012779	-0.7404248	—	—
TC06004089.hg.1	-0.7503608	3.111108	-4.681769	0.0012852	0.0012852	-0.7412549	RP11-446F17.3	novel transcript, antisense to SLC25A27
TC12003289.hg.1	0.5807177	5.626701	4.671636	0.0012793	0.0012793	-0.7414827	C12orf57	chromosome 12 open reading frame 57
TC05002693.hg.1	-0.8991783	5.570583	-4.711740	0.0013123	0.0013123	-0.7460339	—	—
TC11002977.hg.1	-0.5855048	7.267416	-4.666721	0.0012880	0.0012880	-0.7483513	LOC388572	uncharacterized LOC388572
TC21000229.hg.1	0.5719911	4.782724	4.665452	0.0012902	0.0012902	-0.7501248	C21orf90	chromosome 21 open reading frame 90
TC04001372.hg.1	-0.7522669	4.047299	-4.669633	0.0013061	0.0013061	-0.7577635	PPM1K	protein phosphatase, Mg2+/Mn2+ dependent, 1K
TC16001352.hg.1	-0.8316968	2.211975	-4.708504	0.0013327	0.0013327	-0.7587406	—	—
TC17000871.hg.1	0.6318337	8.961459	4.657213	0.0013050	0.0013050	-0.7616481	RNU6-24P	RNA, U6 small nuclear 24, pseudogene
TC09001565.hg.1	0.9270954	5.872256	4.700514	0.0013412	0.0013412	-0.7663636	SNORD90	small nucleolar RNA, C/D box 90
TC10002461.hg.1	0.6156151	4.697262	4.651571	0.0013152	0.0013152	-0.7695461	—	—
TC07000794.hg.1	0.7005690	6.283024	4.643783	0.0013294	0.0013294	-0.7804549	—	—
TC04002693.hg.1	0.7701072	7.146621	4.648077	0.0013330	0.0013330	-0.7808747	PDE5A	phosphodiesterase 5A, cGMP-specific
TC15001997.hg.1	0.4562143	2.426173	4.640822	0.0013348	0.0013348	-0.7846059	RNU6-322P	RNA, U6 small nuclear 322, pseudogene
TC10001533.hg.1	0.6396962	6.807266	4.639221	0.0013378	0.0013378	-0.7868494	—	—
TC02002627.hg.1	-0.5708666	8.505459	-4.634718	0.0013462	0.0013462	-0.7931643	SDPR	serum deprivation response
TC0X000829.hg.1	0.8745815	6.834958	4.651306	0.0013592	0.0013592	-0.7942409	KAL1	Kallmann syndrome 1 sequence
TC21000297.hg.1	0.5771898	4.915573	4.631997	0.0013512	0.0013512	-0.7969815	BTF3L4P1	basic transcription factor 3-like 4 pseudogene 1
TC0X001609.hg.1	0.5930526	8.087177	4.630191	0.0013546	0.0013546	-0.7995158	TXLNG	taxilin gamma
TC6_mann_hap4000196.hg.1	0.5197086	6.184528	4.630075	0.0013548	0.0013548	-0.7996798	CFB	complement factor B
TC21000773.hg.1	0.5698180	5.308096	4.629379	0.0013561	0.0013561	-0.8006562	—	—
TC0X000616.hg.1	0.6725033	7.003434	4.624653	0.0013650	0.0013650	-0.8072917	OCRL	oculocerebrorenal syndrome of Lowe
TC02002455.hg.1	-0.5085876	5.866589	-4.622308	0.0013695	0.0013695	-0.8105843	ACVR1	activin A receptor, type I
TC06002065.hg.1	1.0822666	5.743290	4.749808	0.0014600	0.0014600	-0.8124053	TBC1D32	TBC1 domain family, member 32
TC19001487.hg.1	0.6382580	5.119337	4.619622	0.0013746	0.0013746	-0.8143582	ZNF781	zinc finger protein 781
TC0X001482.hg.1	0.5101128	5.860621	4.619029	0.0013757	0.0013757	-0.8151918	TMEM185A	transmembrane protein 185A
TC19000196.hg.1	-0.7556100	6.711875	-4.622488	0.0013809	0.0013809	-0.8166918	—	—
3271690_st	0.5625359	11.316639	4.616767	0.0013800	0.0013800	-0.8183700	—	—
TC08002238.hg.1	0.6824956	2.510380	4.619985	0.0013928	0.0013928	-0.8240057	—	—
TC06001508.hg.1	-0.5751758	7.758479	-4.612595	0.0013880	0.0013880	-0.8242351	FLOT1	flotillin 1
TC01000007.hg.1	-0.6282356	9.293469	-4.607902	0.0013971	0.0013971	-0.8308363	LINC01061	long intergenic non-protein coding RNA 1061
TC01001876.hg.1	-0.6282356	9.293469	-4.607902	0.0013971	0.0013971	-0.8308363	LINC01061	long intergenic non-protein coding RNA 1061
TC01002067.hg.1	-0.6282356	9.293469	-4.607902	0.0013971	0.0013971	-0.8308363	—	—
TC01002069.hg.1	-0.6282356	9.293469	-4.607902	0.0013971	0.0013971	-0.8308363	—	—
TC01003863.hg.1	-0.6282356	9.293469	-4.607902	0.0013971	0.0013971	-0.8308363	—	—
TC0X001491.hg.1	0.7304112	4.960542	4.614319	0.0014037	0.0014037	-0.8319415	GABRE	gamma-aminobutyric acid (GABA) A receptor, epsilon
TC14000383.hg.1	0.5118138	3.847440	4.606992	0.0013989	0.0013989	-0.8321162	—	—
TC09001706.hg.1	0.6049583	5.565194	4.605330	0.0014021	0.0014021	-0.8344544	MIR3689D1	microRNA 3689d-1
TC16002071.hg.1	-0.5847982	6.338509	-4.601456	0.0014097	0.0014097	-0.8399079	MVP	major vault protein
TC06000427.hg.1	-0.5717358	6.027869	-4.600862	0.0014108	0.0014108	-0.8407436	ITPR3	inositol 1,4,5-trisphosphate receptor, type 3
TC07001915.hg.1	-0.5833418	6.071829	-4.600565	0.0014114	0.0014114	-0.8411626	HIPK2	homeodomain interacting protein kinase 2
TC02001174.hg.1	-0.5058714	5.246260	-4.600306	0.0014119	0.0014119	-0.8415272	CFLAR	CASP8 and FADD-like apoptosis regulator
TC01004093.hg.1	0.6237810	4.553937	4.598818	0.0014148	0.0014148	-0.8436217	LYPD8	LY6/PLAUR domain containing 8
TC0X000769.hg.1	0.5346741	6.436371	4.597266	0.0014179	0.0014179	-0.8458076	RPL10	ribosomal protein L10
47419283_st	0.7229645	1.969319	4.620579	0.0014371	0.0014371	-0.8471081	—	—
TC18000300.hg.1	0.5658714	9.082775	4.594039	0.0014243	0.0014243	-0.8503532	EPB41L3	erythrocyte membrane protein band 4.1-like 3
TC14001195.hg.1	0.4617830	2.389882	4.593743	0.0014248	0.0014248	-0.8507708	LOC101927780	uncharacterized LOC101927780
TC08001720.hg.1	-0.6841245	6.374256	-4.591004	0.0014303	0.0014303	-0.8546308	NAPRT	nicotinate phosphoribosyltransferase
TC14000938.hg.1	0.5724320	3.394417	4.590918	0.0014304	0.0014304	-0.8547523	—	—
TC15000791.hg.1	0.5974426	4.088541	4.590731	0.0014308	0.0014308	-0.8550152	SNHG21	small nucleolar RNA host gene 21 (non-protein coding)
TC0Y000098.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC0Y000205.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000772.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000779.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000785.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000807.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000811.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15000826.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001740.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001742.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001747.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001751.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001753.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC15001770.hg.1	0.7371739	5.363736	4.596511	0.0014406	0.0014406	-0.8578956	—	—
TC02003688.hg.1	0.9096258	3.726422	4.636140	0.0014723	0.0014723	-0.8593487	—	—
TC13000077.hg.1	-0.5553240	8.147378	-4.587357	0.0014375	0.0014375	-0.8597724	GTF3A	general transcription factor IIIA
TC13001677.hg.1	-0.6231398	4.564952	-4.587041	0.0014382	0.0014382	-0.8602176	—	—
TC14000544.hg.1	0.6948210	4.925342	4.591386	0.0014416	0.0014416	-0.8603607	FOXN3-AS1	FOXN3 antisense RNA 1
TC03002784.hg.1	-0.5140932	3.934821	-4.586935	0.0014384	0.0014384	-0.8603669	—	—
TC06000669.hg.1	-0.4910209	3.364728	-4.585231	0.0014418	0.0014418	-0.8627697	LRRC1	—
TC0X002147.hg.1	0.6561140	2.333089	4.590245	0.0014457	0.0014457	-0.8628660	—	—
TC03000985.hg.1	0.6472625	7.344244	4.583260	0.0014458	0.0014458	-0.8655506	KLHL24	kelch-like family member 24
TC08001684.hg.1	-0.5400497	6.898156	-4.582966	0.0014464	0.0014464	-0.8659645	AGO2	argonaute RISC catalytic component 2
TC10001133.hg.1	0.6605522	4.495625	4.579918	0.0014525	0.0014525	-0.8702648	MKX	mohawk homeobox
TC0X002140.hg.1	0.5165435	5.287853	4.579683	0.0014530	0.0014530	-0.8705971	BRWD3	bromodomain and WD repeat domain containing 3
TC02001441.hg.1	-0.5234389	5.266045	-4.579436	0.0014535	0.0014535	-0.8709455	MLPH	melanophilin
TC09001479.hg.1	0.5663500	4.651295	4.577522	0.0014573	0.0014573	-0.8736470	RNY4P18	RNA, Ro-associated Y4 pseudogene 18
TC10000339.hg.1	0.6099852	6.893542	4.572690	0.0014672	0.0014672	-0.8804685	PARG	poly (ADP-ribose) glycohydrolase
2978678_st	-0.7666937	8.256418	-4.576772	0.0014712	0.0014712	-0.8809310	—	—
TC14001148.hg.1	0.6545978	5.816169	4.567849	0.0014771	0.0014771	-0.8873066	BMP4	bone morphogenetic protein 4
TC6_qbl_hap6000148.hg.1	-0.5456578	6.895382	-4.567719	0.0014774	0.0014774	-0.8874914	HLA-B	major histocompatibility complex, class I, B
TC10001369.hg.1	0.5985794	6.732252	4.567459	0.0014779	0.0014779	-0.8878584	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
TC03002926.hg.1	0.6703550	5.104894	4.566556	0.0014835	0.0014835	-0.8909966	—	—
TC01001071.hg.1	0.6807039	5.375117	4.566365	0.0014861	0.0014861	-0.8923705	—	—
TC01001136.hg.1	0.6807039	5.375117	4.566365	0.0014861	0.0014861	-0.8923705	RNVU1-3	RNA, variant U1 small nuclear 3
TC0X001706.hg.1	-0.5402827	3.870511	-4.563882	0.0014853	0.0014853	-0.8929138	CCNB3	cyclin B3
TC20001333.hg.1	-0.5176291	6.140878	-4.562380	0.0014884	0.0014884	-0.8950363	—	—
TC08001487.hg.1	0.6463768	2.556222	4.566218	0.0014929	0.0014929	-0.8958061	—	—
TC10001391.hg.1	0.7649127	1.341372	4.634565	0.0015471	0.0015471	-0.8968003	—	—
TC02002291.hg.1	-0.6994430	7.889227	-4.560795	0.0014917	0.0014917	-0.8972785	SAP130	Sin3A-associated protein, 130kDa
TC02000971.hg.1	-0.6683664	4.597853	-4.558725	0.0014998	0.0014998	-0.9020609	RNA5SP108	RNA, 5S ribosomal pseudogene 108
TC09002918.hg.1	0.6087390	5.912291	4.556936	0.0014998	0.0014998	-0.9027358	STRBP	spermatid perinuclear RNA binding protein
TC03003286.hg.1	-0.5415147	3.558113	-4.553450	0.0015071	0.0015071	-0.9076684	—	—
TC13000669.hg.1	-0.4296828	1.687855	-4.550004	0.0015143	0.0015143	-0.9125461	MIR3613	microRNA 3613
TC20000398.hg.1	0.6297790	5.656446	4.549372	0.0015157	0.0015157	-0.9134397	LINC01273	long intergenic non-protein coding RNA 1273
TC01002598.hg.1	0.5716935	9.821603	4.543573	0.0015280	0.0015280	-0.9216528	RNU5D-1	RNA, U5D small nuclear 1
TC07003132.hg.1	-0.5634322	2.456242	-4.542769	0.0015297	0.0015297	-0.9227919	AC003084.2	putative novel transcript
TC0X001516.hg.1	0.5441907	7.895011	4.541568	0.0015323	0.0015323	-0.9244938	BCAP31	B-cell receptor-associated protein 31
TC01000849.hg.1	0.5524316	5.093830	4.540928	0.0015336	0.0015336	-0.9254011	EPHX4	epoxide hydrolase 4
TC01003877.hg.1	-0.6493883	8.251193	-4.539800	0.0015361	0.0015361	-0.9269989	—	—
TC16001143.hg.1	0.6478216	8.294137	4.539619	0.0015364	0.0015364	-0.9272560	RNU6-20P	RNA, U6 small nuclear 20, pseudogene
TC11000563.hg.1	0.6114590	7.665984	4.538522	0.0015388	0.0015388	-0.9288107	POLR2G	polymerase (RNA) II (DNA directed) polypeptide G
TC15002670.hg.1	0.5651388	2.356551	4.535248	0.0015459	0.0015459	-0.9334521	—	—
PSR11017826.hg.1	0.5871816	9.916827	4.534668	0.0015471	0.0015471	-0.9342741	—	—
TC0X001945.hg.1	0.6133817	5.250985	4.534096	0.0015484	0.0015484	-0.9350857	—	—
TC10001225.hg.1	0.4831837	4.138507	4.533206	0.0015503	0.0015503	-0.9363472	ZFAND4	zinc finger, AN1-type domain 4
TC14001209.hg.1	0.9318052	7.396163	4.566730	0.0015785	0.0015785	-0.9368915	SGPP1	sphingosine-1-phosphate phosphatase 1
TC10001298.hg.1	0.5810914	3.908081	4.532308	0.0015522	0.0015522	-0.9376213	PRKG1-AS1	PRKG1 antisense RNA 1
TC19001784.hg.1	0.5257642	5.067515	4.531127	0.0015548	0.0015548	-0.9392967	SIGLEC14	sialic acid binding Ig-like lectin 14
TC10000145.hg.1	0.6812927	6.963179	4.531087	0.0015549	0.0015549	-0.9393531	PLXDC2	plexin domain containing 2
TC05003006.hg.1	-0.5717693	2.234911	-4.528387	0.0015608	0.0015608	-0.9431843	—	—
TC11002076.hg.1	0.6764113	6.783388	4.527618	0.0015624	0.0015624	-0.9442753	C2CD3	C2 calcium-dependent domain containing 3
TC15000167.hg.1	0.7172763	7.153915	4.527328	0.0015642	0.0015642	-0.9452153	—	—
TC15001126.hg.1	0.7172763	7.153915	4.527328	0.0015642	0.0015642	-0.9452153	—	—
47423824_st	0.6329183	1.629774	4.539052	0.0015750	0.0015750	-0.9458052	—	—
TC13000610.hg.1	0.5127735	2.197329	4.526090	0.0015658	0.0015658	-0.9464434	FABP3P2	fatty acid binding protein 3, pseudogene 2
TC07001738.hg.1	-0.5517489	7.106112	-4.525075	0.0015680	0.0015680	-0.9478840	NAMPT	nicotinamide phosphoribosyltransferase
TC22000926.hg.1	0.6467416	5.024625	4.524918	0.0015684	0.0015684	-0.9481071	—	—
TC0X000597.hg.1	0.7356825	5.486709	4.532125	0.0015753	0.0015753	-0.9485725	GLUD2	glutamate dehydrogenase 2
TC06000048.hg.1	-0.7009219	6.934876	-4.522995	0.0015726	0.0015726	-0.9508368	FARS2	phenylalanyl-tRNA synthetase 2, mitochondrial
47421529_st	-1.3189242	2.093812	-4.917576	0.0018936	0.0018936	-0.9509027	—	—
TC03000371.hg.1	0.5113450	1.798374	4.522525	0.0015736	0.0015736	-0.9515047	RP11-755B10.2	putative novel transcript
TC02004129.hg.1	-0.8044414	7.608495	-4.529353	0.0015841	0.0015841	-0.9537765	SLC5A6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TC01001188.hg.1	-0.7502560	6.160984	-4.527183	0.0015861	0.0015861	-0.9555584	ECM1	extracellular matrix protein 1
TC08001906.hg.1	0.5823470	4.392198	4.517686	0.0015843	0.0015843	-0.9583768	—	—
TC10002078.hg.1	0.5714430	8.858091	4.514776	0.0015908	0.0015908	-0.9625106	TFAM	transcription factor A, mitochondrial
TC13000493.hg.1	-0.5869655	6.647718	-4.514057	0.0015924	0.0015924	-0.9635328	CENPJ	centromere protein J
TC12002907.hg.1	0.6592072	3.394504	4.514438	0.0015955	0.0015955	-0.9648085	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC08000728.hg.1	0.5603931	4.734029	4.512627	0.0015956	0.0015956	-0.9655660	ZNF572	zinc finger protein 572
TC09000291.hg.1	0.4940664	3.611775	4.512307	0.0015963	0.0015963	-0.9660209	—	—
TC19001585.hg.1	-0.5742267	5.357545	-4.511997	0.0015970	0.0015970	-0.9664609	CD177P1	CD177 molecule pseudogene 1
TC0X000922.hg.1	0.6703941	4.475257	4.513677	0.0016009	0.0016009	-0.9676273	RP13-314C10.5	novel transcript
TC15001330.hg.1	-1.3867498	3.784210	-4.859920	0.0018900	0.0018900	-0.9679131	MYEF2	myelin expression factor 2
TC14001198.hg.1	0.9967474	2.933249	4.627375	0.0016983	0.0016983	-0.9685317	HIF1A-AS2	HIF1A antisense RNA 2
TC03002562.hg.1	0.7712983	3.185145	4.522738	0.0016209	0.0016209	-0.9732898	—	—
TC14001303.hg.1	0.6607860	5.342028	4.506888	0.0016124	0.0016124	-0.9755354	ALDH6A1	aldehyde dehydrogenase 6 family, member A1
TC05000613.hg.1	-0.6572029	4.412151	-4.505151	0.0016164	0.0016164	-0.9780042	SLC27A6	solute carrier family 27 (fatty acid transporter), member 6
TC0Y000310.hg.1	0.6370928	4.574181	4.503642	0.0016158	0.0016158	-0.9783419	—	—
TC01004837.hg.1	1.2765339	5.903365	4.758826	0.0018321	0.0018321	-0.9783910	—	—
TC11002356.hg.1	0.6545624	4.872276	4.504826	0.0016171	0.0016171	-0.9784666	—	—
TC03001651.hg.1	0.5859388	6.461674	4.501784	0.0016200	0.0016200	-0.9809853	CCDC80	coiled-coil domain containing 80
TC21000898.hg.1	-0.4725414	3.381546	-4.499566	0.0016251	0.0016251	-0.9841428	—	—
TC11001691.hg.1	-0.8452290	2.483774	-4.547291	0.0016687	0.0016687	-0.9853152	—	—
TC05001833.hg.1	0.5005720	4.554589	4.498231	0.0016281	0.0016281	-0.9860424	—	—
TC17000090.hg.1	0.6062318	5.496198	4.497736	0.0016293	0.0016293	-0.9867473	KCTD11	potassium channel tetramerization domain containing 11
TC02001100.hg.1	-0.5994473	8.430972	-4.496456	0.0016322	0.0016322	-0.9885700	ITGAV	integrin, alpha V
TC06001228.hg.1	0.8530636	5.829701	4.524329	0.0016631	0.0016631	-0.9916378	TUBB2B	tubulin, beta 2B class IIb
TC01003152.hg.1	0.5628092	7.797842	4.489989	0.0016471	0.0016471	-0.9977797	RNVU1-15	RNA, variant U1 small nuclear 15
TC01004166.hg.1	0.7022339	8.089467	4.489973	0.0016471	0.0016471	-0.9978034	CAMTA1	calmodulin binding transcription activator 1
TC20001330.hg.1	-0.4152199	1.723340	-4.489758	0.0016476	0.0016476	-0.9981093	RP5-827L5.1	putative novel transcript
TC02004031.hg.1	-0.5315703	3.946950	-4.489462	0.0016483	0.0016483	-0.9985318	—	—
2891949_st	1.1406776	9.757848	4.649533	0.0017885	0.0017885	-0.9987645	—	—
TC14000278.hg.1	0.5296889	6.621531	4.488114	0.0016514	0.0016514	-1.0004519	KLHDC2	kelch domain containing 2
TC10002925.hg.1	-0.7119044	7.800035	-4.486815	0.0016544	0.0016544	-1.0023036	AKR1C3	aldo-keto reductase family 1, member C3
TC14000491.hg.1	0.5458090	8.665010	4.485666	0.0016571	0.0016571	-1.0039414	AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
TC0X000007.hg.1	0.8445237	2.539709	4.531732	0.0017044	0.0017044	-1.0068567	MIR3690	microRNA 3690
TC0Y000007.hg.1	0.8445237	2.539709	4.531732	0.0017044	0.0017044	-1.0068567	MIR3690	microRNA 3690
TC0X000743.hg.1	0.5958718	7.471504	4.482880	0.0016636	0.0016636	-1.0079126	NSDHL	NAD(P) dependent steroid dehydrogenase-like
TC19000397.hg.1	0.6959202	5.689519	4.486390	0.0016689	0.0016689	-1.0088696	ZNF729	zinc finger protein 729
TC02000705.hg.1	-0.6689549	5.489751	-4.483312	0.0016666	0.0016666	-1.0090864	ZC3H6	zinc finger CCCH-type containing 6
TC07001055.hg.1	0.5234606	7.538844	4.481763	0.0016662	0.0016662	-1.0095054	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6
TC07002355.hg.1	0.4482747	1.787859	4.481416	0.0016670	0.0016670	-1.0100003	—	—
TC01001184.hg.1	0.5612515	9.172759	4.480213	0.0016699	0.0016699	-1.0117157	MRPS21	mitochondrial ribosomal protein S21
TC0X001968.hg.1	0.5768580	7.557253	4.479452	0.0016716	0.0016716	-1.0128011	—	—
TC19001525.hg.1	0.5131968	5.859534	4.478630	0.0016736	0.0016736	-1.0139735	DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
TC10001400.hg.1	0.6819237	5.503602	4.480798	0.0016813	0.0016813	-1.0165130	—	—
TC0X000329.hg.1	-0.5041323	9.924390	-4.476616	0.0016783	0.0016783	-1.0168470	PAGE5	P antigen family, member 5 (prostate associated)
TC03000281.hg.1	0.5314196	8.343746	4.476568	0.0016784	0.0016784	-1.0169162	TMA7	translation machinery associated 7 homolog (S. cerevisiae)
TC07001152.hg.1	-0.4933718	5.285768	-4.473128	0.0016866	0.0016866	-1.0218251	ETV1	ets variant 1
TC02000510.hg.1	0.4786286	3.177534	4.469060	0.0016963	0.0016963	-1.0276318	—	—
TC14002197.hg.1	0.5531967	9.908250	4.468662	0.0016972	0.0016972	-1.0282002	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
TC01001749.hg.1	0.6969100	6.928468	4.467029	0.0017011	0.0017011	-1.0305317	G0S2	G0/G1 switch 2
TC0X000135.hg.1	-0.5154697	1.958387	-4.464271	0.0017077	0.0017077	-1.0344714	RP1-146A15.1	putative novel transcript
TC17000775.hg.1	0.4980068	10.260313	4.463266	0.0017102	0.0017102	-1.0359085	SNORD104	small nucleolar RNA, C/D box 104
TC14002297.hg.1	0.5861377	6.876976	4.462974	0.0017109	0.0017109	-1.0363256	MNAT1	MNAT CDK-activating kinase assembly factor 1
TC01005261.hg.1	0.5628622	6.200666	4.461681	0.0017140	0.0017140	-1.0381723	—	—
TC05000743.hg.1	0.5002068	3.821919	4.458774	0.0017210	0.0017210	-1.0423273	PCDHB2	protocadherin beta 2
TC16001301.hg.1	0.8511759	5.174646	4.496186	0.0017588	0.0017588	-1.0436402	SDR42E1	short chain dehydrogenase/reductase family 42E, member 1
TC6_mann_hap4000173.hg.1	-0.5498393	6.756915	-4.456060	0.0017276	0.0017276	-1.0462082	VPS52	vacuolar protein sorting 52 homolog (S. cerevisiae)
3149249_st	0.9215160	9.587136	4.498932	0.0017702	0.0017702	-1.0473293	—	—
TC15000437.hg.1	0.5356538	5.700812	4.454823	0.0017306	0.0017306	-1.0479757	CGNL1	cingulin-like 1
TC01002337.hg.1	-0.7218817	6.517710	-4.457365	0.0017383	0.0017383	-1.0502167	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
TC05001308.hg.1	0.6905829	4.145407	4.457786	0.0017393	0.0017393	-1.0504619	—	—
47423062_st	-0.7142748	1.736078	-4.490077	0.0017698	0.0017698	-1.0505838	—	—
TC07001186.hg.1	-0.6046241	4.696579	-4.452277	0.0017368	0.0017368	-1.0516176	STEAP1B	STEAP family member 1B
TC01005259.hg.1	-0.5248104	8.365548	-4.451545	0.0017386	0.0017386	-1.0526650	CLSTN1	calsyntenin 1
TC17001593.hg.1	0.8611488	3.611849	4.490824	0.0017828	0.0017828	-1.0556768	AC002117.1	novel transcript, antisense to HEXIM1 and HEXIM2
TC06000681.hg.1	-0.5448679	3.653486	-4.449209	0.0017444	0.0017444	-1.0560065	BEND6	BEN domain containing 6
TC08000689.hg.1	0.5476907	4.797947	4.448600	0.0017459	0.0017459	-1.0568791	MED30	mediator complex subunit 30
TC0X000116.hg.1	0.7593593	6.803921	4.454641	0.0017542	0.0017542	-1.0579985	ZFX	zinc finger protein, X-linked
TC14001351.hg.1	0.5343920	4.659803	4.446855	0.0017502	0.0017502	-1.0593757	—	—
TC02001677.hg.1	-0.7099699	6.983346	-4.448075	0.0017514	0.0017514	-1.0593881	SLC5A6	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TC19002207.hg.1	-0.5246384	3.021703	-4.442171	0.0017618	0.0017618	-1.0660808	KLK3	kallikrein-related peptidase 3
TC09002783.hg.1	0.6223149	7.013514	4.439299	0.0017689	0.0017689	-1.0701942	STRBP	spermatid perinuclear RNA binding protein
TC19001581.hg.1	-0.5233572	7.582497	-4.438121	0.0017719	0.0017719	-1.0718820	PSG2	pregnancy specific beta-1-glycoprotein 2
TC06001988.hg.1	-0.5399009	3.665085	-4.438076	0.0017720	0.0017720	-1.0719468	PDSS2	prenyl (decaprenyl) diphosphate synthase, subunit 2
TC03001924.hg.1	-0.6171826	2.356147	-4.442100	0.0017760	0.0017760	-1.0720136	MME-AS1	MME antisense RNA 1
TC0X000792.hg.1	0.6173618	8.537190	4.437888	0.0017725	0.0017725	-1.0722162	VAMP7	vesicle-associated membrane protein 7
TC03000863.hg.1	0.5225618	4.238824	4.436658	0.0017755	0.0017755	-1.0739775	C3orf55	chromosome 3 open reading frame 55
TC04001525.hg.1	0.6918750	5.192265	4.438798	0.0017864	0.0017864	-1.0775704	—	—
TC17000468.hg.1	0.6918750	5.192265	4.438798	0.0017864	0.0017864	-1.0775704	—	—
TC17001443.hg.1	0.6918750	5.192265	4.438798	0.0017864	0.0017864	-1.0775704	—	—
TC17001444.hg.1	0.6918750	5.192265	4.438798	0.0017864	0.0017864	-1.0775704	—	—
TC0X001504.hg.1	0.5514766	7.478207	4.433925	0.0017824	0.0017824	-1.0778943	MAGEA2	melanoma antigen family A, 2
TC6_mann_hap4000187.hg.1	-0.5139775	9.219660	-4.430517	0.0017910	0.0017910	-1.0827788	HLA-C	major histocompatibility complex, class I, C
TC04001769.hg.1	0.5186380	6.992749	4.430262	0.0017917	0.0017917	-1.0831444	AGA	aspartylglucosaminidase
TC04001589.hg.1	0.7804126	5.548345	4.443647	0.0018098	0.0018098	-1.0852149	CLGN	calmegin
TC16000700.hg.1	-0.6577194	7.171888	-4.427885	0.0017977	0.0017977	-1.0865531	CPNE7	copine VII
TC08001408.hg.1	-0.5446737	6.344419	-4.427757	0.0017980	0.0017980	-1.0867369	TMEM55A	transmembrane protein 55A
TC14001134.hg.1	0.5966757	5.382381	4.426451	0.0018013	0.0018013	-1.0886091	FRMD6-AS1	FRMD6 antisense RNA 1
TC04000524.hg.1	0.4229366	2.262084	4.426019	0.0018024	0.0018024	-1.0892294	BANK1	B-cell scaffold protein with ankyrin repeats 1
TC10002734.hg.1	0.7150792	4.988474	4.433412	0.0018133	0.0018133	-1.0906751	ANXA11	annexin A11
TC17001551.hg.1	0.3845011	1.462113	4.424823	0.0018055	0.0018055	-1.0909456	—	—
TC04001621.hg.1	-0.6809882	5.476388	-4.428363	0.0018108	0.0018108	-1.0916588	SLC10A7	solute carrier family 10, member 7
TC06001967.hg.1	0.5193631	1.510173	4.422385	0.0018117	0.0018117	-1.0944435	—	—
TC6_mcf_hap5000194.hg.1	-0.5329701	8.990849	-4.420304	0.0018171	0.0018171	-1.0974299	HLA-C	major histocompatibility complex, class I, C
TC01000994.hg.1	-0.5134791	6.485662	-4.419526	0.0018191	0.0018191	-1.0985458	RP3-522D1.1	novel transcript
TC07002680.hg.1	0.4316289	2.274739	4.417918	0.0018232	0.0018232	-1.1008545	GALNTL5	polypeptide N-acetylgalactosaminyltransferase-like 5
TC04002434.hg.1	-0.5347328	2.824093	-4.416823	0.0018260	0.0018260	-1.1024264	—	—
TC03000728.hg.1	0.5289786	2.349358	4.415982	0.0018282	0.0018282	-1.1036330	MIR4788	microRNA 4788
TC6_cox_hap2000142.hg.1	-0.5470234	7.743962	-4.415874	0.0018285	0.0018285	-1.1037885	FLOT1	flotillin 1
TC0X002220.hg.1	0.9200461	4.755874	4.482520	0.0018965	0.0018965	-1.1042332	STAG2	stromal antigen 2
TC03000655.hg.1	0.6069865	5.256132	4.414848	0.0018312	0.0018312	-1.1052619	LOC644662	uncharacterized LOC644662
TC0X001586.hg.1	-0.6639109	5.619636	-4.413907	0.0018407	0.0018407	-1.1094410	VCX	variable charge, X-linked
TC0X000847.hg.1	-0.5235883	4.458944	-4.411623	0.0018395	0.0018395	-1.1098936	—	—
TC15000348.hg.1	0.6516631	8.193112	4.410004	0.0018438	0.0018438	-1.1122198	RNU6-1332P	RNA, U6 small nuclear 1332, pseudogene
TC18000857.hg.1	0.5264984	2.433870	4.409135	0.0018460	0.0018460	-1.1134683	—	—
TC14000219.hg.1	0.5604844	7.906188	4.405711	0.0018550	0.0018550	-1.1183889	SRP54	signal recognition particle 54kDa
TC12000919.hg.1	0.6975452	6.542024	4.407441	0.0018600	0.0018600	-1.1196447	RNU6-558P	RNA, U6 small nuclear 558, pseudogene
TC15001161.hg.1	0.6661670	7.443509	4.403991	0.0018595	0.0018595	-1.1208615	MTMR10	myotubularin related protein 10
TC19001365.hg.1	0.5757893	5.388457	4.403606	0.0018605	0.0018605	-1.1214147	IPO5P1	importin 5 pseudogene 1
TC14000989.hg.1	0.4637081	1.514358	4.403165	0.0018617	0.0018617	-1.1220487	LOC101927062	uncharacterized LOC101927062
TC11002686.hg.1	0.6885740	5.241128	4.407358	0.0018674	0.0018674	-1.1225758	DTX4	deltex 4, E3 ubiquitin ligase
TC10000443.hg.1	0.5063736	7.099781	4.402123	0.0018645	0.0018645	-1.1235471	ANAPC16	anaphase promoting complex subunit 16
TC12002273.hg.1	-0.4674305	1.933545	-4.401931	0.0018650	0.0018650	-1.1238229	—	—
TC13000420.hg.1	-0.5692501	3.793801	-4.401830	0.0018652	0.0018652	-1.1239693	CUL4A	cullin 4A
TC04001820.hg.1	0.4950748	2.951504	4.400870	0.0018678	0.0018678	-1.1253493	SORBS2	sorbin and SH3 domain containing 2
TC07003253.hg.1	-0.5234017	4.894940	-4.399835	0.0018705	0.0018705	-1.1268370	—	—
TC03000496.hg.1	0.5871966	1.726500	4.405869	0.0018775	0.0018775	-1.1271468	CTD-2021J15.1	novel transcript
TC01002739.hg.1	-0.5194535	3.746661	-4.399502	0.0018714	0.0018714	-1.1273164	ROR1-AS1	ROR1 antisense RNA 1
TC07000650.hg.1	-0.5156206	6.264154	-4.398854	0.0018731	0.0018731	-1.1282490	CUX1	cut-like homeobox 1
TC6_dbb_hap3000131.hg.1	-0.5421578	7.736711	-4.397492	0.0018767	0.0018767	-1.1302076	FLOT1	flotillin 1
TC6_qbl_hap6000132.hg.1	-0.5421578	7.736711	-4.397492	0.0018767	0.0018767	-1.1302076	FLOT1	flotillin 1
TC6_ssto_hap7000122.hg.1	-0.5421578	7.736711	-4.397492	0.0018767	0.0018767	-1.1302076	FLOT1	flotillin 1
TC03002316.hg.1	0.5073201	4.011630	4.396545	0.0018793	0.0018793	-1.1315711	—	—
TC10001110.hg.1	0.5969165	6.386679	4.395693	0.0018815	0.0018815	-1.1327964	PRTFDC1	phosphoribosyl transferase domain containing 1
TC11003342.hg.1	-0.7658862	3.445238	-4.406064	0.0019114	0.0019114	-1.1401007	FDXACB1	ferredoxin-fold anticodon binding domain containing 1
TC04002840.hg.1	-1.1887299	7.272960	-4.555305	0.0020719	0.0020719	-1.1414357	—	—
TC14001084.hg.1	0.5393662	7.325544	4.389069	0.0018993	0.0018993	-1.1423300	FKBP3	FK506 binding protein 3, 25kDa
TC0X000747.hg.1	0.5445861	4.476848	4.388260	0.0019015	0.0019015	-1.1434954	ZNF275	zinc finger protein 275
47420665_st	-1.8279843	2.108061	-5.115252	0.0026717	0.0026717	-1.1481921	—	—
TC11000190.hg.1	0.5472357	5.819122	4.384615	0.0019113	0.0019113	-1.1487455	ZBED5-AS1	ZBED5 antisense RNA 1
TC06002403.hg.1	-0.8050409	4.361716	-4.409254	0.0019475	0.0019475	-1.1524651	FOXC1	forkhead box C1
TC14002080.hg.1	1.3668100	5.108670	4.715924	0.0022786	0.0022786	-1.1540393	—	—
TC12001705.hg.1	0.7183375	4.996278	4.389267	0.0019305	0.0019305	-1.1541406	CPM	carboxypeptidase M
TC04000733.hg.1	0.6092634	6.532637	4.379733	0.0019246	0.0019246	-1.1557789	ARHGAP10	Rho GTPase activating protein 10
TC01002637.hg.1	-0.5172869	4.560676	-4.378366	0.0019284	0.0019284	-1.1577492	SPATA6	spermatogenesis associated 6
TC06002062.hg.1	-0.5690818	5.282369	-4.375846	0.0019353	0.0019353	-1.1613827	MAN1A1	mannosidase, alpha, class 1A, member 1
TC06002690.hg.1	-0.5344643	8.087634	-4.373889	0.0019407	0.0019407	-1.1642045	—	—
2909168_st	-0.5035867	9.623487	-4.373434	0.0019419	0.0019419	-1.1648605	—	—
TC05000073.hg.1	0.5243925	4.738434	4.372172	0.0019454	0.0019454	-1.1666803	—	—
TC09000335.hg.1	-0.5007801	9.862884	-4.372012	0.0019459	0.0019459	-1.1669122	ANXA1	annexin A1
PSR11002187.hg.1	0.6067501	7.765836	4.369993	0.0019515	0.0019515	-1.1698239	—	—
TC10000772.hg.1	0.5028219	5.899242	4.369184	0.0019537	0.0019537	-1.1709907	TAF5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TC04002753.hg.1	0.8388446	6.285086	4.394687	0.0019875	0.0019875	-1.1731222	CLGN	calmegin
TC12001261.hg.1	-0.5663358	7.157204	-4.365447	0.0019641	0.0019641	-1.1763836	GSG1	germ cell associated 1
TC11000924.hg.1	-0.5061794	6.783129	-4.364347	0.0019672	0.0019672	-1.1779714	AMOTL1	angiomotin like 1
TC14002026.hg.1	0.7187191	4.355524	4.371070	0.0019840	0.0019840	-1.1814002	—	—
TC03002773.hg.1	-0.5784804	7.481966	-4.361166	0.0019761	0.0019761	-1.1825644	—	—
TC03002312.hg.1	-0.5397994	5.279870	-4.360201	0.0019788	0.0019788	-1.1839574	—	—
TC05000238.hg.1	0.4841600	3.478233	4.360015	0.0019794	0.0019794	-1.1842265	IL31RA	interleukin 31 receptor A
TC05003017.hg.1	-0.4368168	1.710830	-4.359955	0.0019795	0.0019795	-1.1843138	—	—
TC08002290.hg.1	0.4770926	3.350402	4.359784	0.0019800	0.0019800	-1.1845608	LOC728024	chromosome X open reading frame 56 pseudogene
TC01000371.hg.1	0.7923627	4.958166	4.383961	0.0020109	0.0020109	-1.1859979	SCARNA1	small Cajal body-specific RNA 1
TC10001205.hg.1	0.4835357	5.643428	4.355899	0.0019910	0.0019910	-1.1901726	ZNF32	zinc finger protein 32
TC13000491.hg.1	-0.6566201	7.867760	-4.355054	0.0019934	0.0019934	-1.1913933	PARP4	poly (ADP-ribose) polymerase family, member 4
TC14001380.hg.1	-0.4322359	1.459173	-4.354254	0.0019957	0.0019957	-1.1925483	—	—
TC08001051.hg.1	0.6004196	4.524840	4.353211	0.0019986	0.0019986	-1.1940562	TNFRSF10D	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TC0X000623.hg.1	0.5784459	6.936850	4.351375	0.0020039	0.0020039	-1.1967090	RBMX2	RNA binding motif protein, X-linked 2
TC08000315.hg.1	0.6209908	3.732517	4.351235	0.0020043	0.0020043	-1.1969122	—	—
TC17002426.hg.1	-0.6617505	4.318455	-4.352490	0.0020161	0.0020161	-1.2006688	FAM101B	family with sequence similarity 101, member B
TC6_ssto_hap7000020.hg.1	-0.5562470	7.443971	-4.346469	0.0020179	0.0020179	-1.2038028	HLA-A	major histocompatibility complex, class I, A
TC01002878.hg.1	0.5916547	5.195522	4.346004	0.0020193	0.0020193	-1.2044757	—	—
TC01003788.hg.1	0.5544707	5.693485	4.345178	0.0020217	0.0020217	-1.2056693	SERTAD4-AS1	SERTAD4 antisense RNA 1
TC0X001832.hg.1	-0.6265672	3.109635	-4.345975	0.0020240	0.0020240	-1.2061860	—	—
TC11002583.hg.1	-0.4921366	4.229620	-4.344147	0.0020246	0.0020246	-1.2071616	KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1
TC09001654.hg.1	0.5661787	8.613923	4.342293	0.0020300	0.0020300	-1.2098434	TOR1A	torsin family 1, member A (torsin A)
TC05002020.hg.1	0.6679574	5.658712	4.345944	0.0020349	0.0020349	-1.2101131	NUDCD2	NudC domain containing 2
TC07000394.hg.1	0.5421316	8.532129	4.340338	0.0020357	0.0020357	-1.2126714	—	—
TC12001355.hg.1	-0.5469646	6.035852	-4.336926	0.0020456	0.0020456	-1.2176105	CAPRIN2	caprin family member 2
TC11001866.hg.1	0.7242504	6.267274	4.340298	0.0020632	0.0020632	-1.2224419	—	—
47423726_st	0.8525754	1.926296	4.436597	0.0021777	0.0021777	-1.2230190	—	—
TC11002813.hg.1	0.5891669	7.513692	4.332785	0.0020577	0.0020577	-1.2236060	TMEM135	transmembrane protein 135
TC07002567.hg.1	-0.6244042	8.730999	-4.332493	0.0020586	0.0020586	-1.2240281	SND1	staphylococcal nuclease and tudor domain containing 1
TC01002267.hg.1	0.5345632	3.938712	4.331865	0.0020604	0.0020604	-1.2249383	—	—
TC01005003.hg.1	0.5382466	4.656080	4.330802	0.0020635	0.0020635	-1.2264779	RP11-15I11.2	novel transcript
TC14001720.hg.1	0.7160494	6.083568	4.336483	0.0020744	0.0020744	-1.2279431	PPM1A	protein phosphatase, Mg2+/Mn2+ dependent, 1A
TC22001314.hg.1	-0.3997386	1.826325	-4.329258	0.0020681	0.0020681	-1.2287144	—	—
TC0X000827.hg.1	0.4839853	6.247712	4.328754	0.0020696	0.0020696	-1.2294439	PNPLA4	patatin-like phospholipase domain containing 4
TC02002684.hg.1	-0.5667452	8.230361	-4.328672	0.0020698	0.0020698	-1.2295632	WDR12	WD repeat domain 12
TC17000672.hg.1	-0.5634965	5.385419	-4.328513	0.0020703	0.0020703	-1.2297931	ABCC3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
TC09001026.hg.1	0.7709604	3.335177	4.348062	0.0020979	0.0020979	-1.2313283	SNORD121A	small nucleolar RNA, C/D box 121A
TC6_dbb_hap3000145.hg.1	-0.5179829	8.727275	-4.326686	0.0020757	0.0020757	-1.2324404	HLA-C	major histocompatibility complex, class I, C
TC08002291.hg.1	0.6979560	7.132311	4.327233	0.0020818	0.0020818	-1.2343521	RAB11FIP1	RAB11 family interacting protein 1 (class I)
TC15000045.hg.1	0.5686944	4.932954	4.324837	0.0020812	0.0020812	-1.2351203	SNORD108	small nucleolar RNA, C/D box 108
TC19000976.hg.1	-0.5141011	7.090153	-4.323914	0.0020839	0.0020839	-1.2364580	LINC01002	long intergenic non-protein coding RNA 1002
3482860_st	0.5704602	9.643448	4.323866	0.0020841	0.0020841	-1.2365279	—	—
TC01004581.hg.1	0.4925262	5.684218	4.322691	0.0020876	0.0020876	-1.2382315	RNPC3	RNA-binding region (RNP1, RRM) containing 3
TC01004428.hg.1	0.4724040	3.495007	4.322360	0.0020886	0.0020886	-1.2387113	LOC101926944	uncharacterized LOC101926944
TC08002460.hg.1	-0.5922039	2.218352	-4.324676	0.0020975	0.0020975	-1.2408434	—	—
TC12001993.hg.1	-0.5100239	7.083575	-4.320146	0.0020952	0.0020952	-1.2419205	RBM19	RNA binding motif protein 19
TC05001362.hg.1	-0.6656234	6.980714	-4.319290	0.0020978	0.0020978	-1.2431619	DHX29	DEAH (Asp-Glu-Ala-His) box polypeptide 29
TC03000518.hg.1	0.5764569	7.808223	4.318882	0.0020990	0.0020990	-1.2437538	TRMT10C	tRNA methyltransferase 10 homolog C (S. cerevisiae)
TC0X001556.hg.1	0.5518392	5.749958	4.317569	0.0021029	0.0021029	-1.2456573	TMLHE	trimethyllysine hydroxylase, epsilon
TC11003029.hg.1	0.5645507	4.315710	4.316540	0.0021060	0.0021060	-1.2471502	OR51B5	olfactory receptor, family 51, subfamily B, member 5
TC01003990.hg.1	0.8649804	7.748463	4.338801	0.0021379	0.0021379	-1.2488369	SNORA14B	small nucleolar RNA, H/ACA box 14B
TC16000921.hg.1	-0.7431735	7.639529	-4.319014	0.0021168	0.0021168	-1.2498236	GPRC5B	G protein-coupled receptor, class C, group 5, member B
TC06000684.hg.1	-0.5827271	8.286831	-4.311947	0.0021199	0.0021199	-1.2538147	BAG2	BCL2-associated athanogene 2
TC12002818.hg.1	-0.5488902	6.332148	-4.309813	0.0021264	0.0021264	-1.2569110	CAPRIN2	caprin family member 2
TC17000715.hg.1	0.5868390	4.595161	4.309298	0.0021280	0.0021280	-1.2576591	PPM1E	protein phosphatase, Mg2+/Mn2+ dependent, 1E
TC10000239.hg.1	0.4617427	4.205514	4.309125	0.0021285	0.0021285	-1.2579108	RNU7-77P	RNA, U7 small nuclear 77 pseudogene
TC20000051.hg.1	-0.5235611	9.297415	-4.307914	0.0021322	0.0021322	-1.2596679	PRNP	prion protein
TC01002772.hg.1	-0.6187077	7.990361	-4.307551	0.0021333	0.0021333	-1.2601949	RP11-180O5.2	putative novel transcript
TC10000148.hg.1	0.5310652	10.334471	4.307459	0.0021336	0.0021336	-1.2603295	RNU6-15P	RNA, U6 small nuclear 15, pseudogene
TC14002200.hg.1	0.5828749	6.424624	4.307222	0.0021343	0.0021343	-1.2606727	ACOT1	acyl-CoA thioesterase 1
TC01002597.hg.1	0.5001312	2.273971	4.306211	0.0021374	0.0021374	-1.2621410	RNU5F-1	RNA, U5F small nuclear 1
TC13000922.hg.1	-0.4822233	3.230043	-4.304668	0.0021421	0.0021421	-1.2643809	—	—
TC20000893.hg.1	0.4859512	5.088442	4.304068	0.0021439	0.0021439	-1.2652521	PLTP	phospholipid transfer protein
TC08000128.hg.1	0.6289488	6.293470	4.302964	0.0021473	0.0021473	-1.2668566	PDGFRL	platelet-derived growth factor receptor-like
TC15000364.hg.1	-0.4602687	4.671709	-4.302633	0.0021483	0.0021483	-1.2673372	SQRDL	sulfide quinone reductase-like (yeast)
47419687_st	-0.5311853	1.488180	-4.303146	0.0021630	0.0021630	-1.2720200	—	—
TC07002886.hg.1	0.4599186	3.234605	4.297240	0.0021650	0.0021650	-1.2751736	TBX20	T-box 20
TC14000462.hg.1	0.5359443	7.042169	4.297015	0.0021657	0.0021657	-1.2755004	FCF1	FCF1 rRNA-processing protein
TC10001536.hg.1	0.4403406	2.958721	4.294835	0.0021725	0.0021725	-1.2786695	RNA5SP323	RNA, 5S ribosomal pseudogene 323
TC10000322.hg.1	0.6381947	6.157888	4.294823	0.0021725	0.0021725	-1.2786868	MAPK8	mitogen-activated protein kinase 8
ERCC-00009_st	-0.4471525	2.062581	-4.293552	0.0021765	0.0021765	-1.2805344	—	—
TC10002704.hg.1	0.5605019	4.679047	4.293110	0.0021779	0.0021779	-1.2811772	—	—
TC14001936.hg.1	0.5064375	9.167031	4.291872	0.0021817	0.0021817	-1.2829765	NEDD8	neural precursor cell expressed, developmentally down-regulated 8
TC10001138.hg.1	-0.4513056	2.316704	-4.291028	0.0021844	0.0021844	-1.2842048	RP11-351M16.3	novel transcript
TC09002052.hg.1	0.6945150	5.192543	4.296674	0.0021989	0.0021989	-1.2866294	—	—
TC02002110.hg.1	-0.4863537	6.843279	-4.288640	0.0021919	0.0021919	-1.2876769	KANSL3	KAT8 regulatory NSL complex subunit 3
TC17002564.hg.1	-0.5473978	1.423881	-4.294095	0.0022005	0.0022005	-1.2882228	—	—
TC04000013.hg.1	-0.5629001	7.061214	-4.288137	0.0021934	0.0021934	-1.2884087	PCGF3	polycomb group ring finger 3
TC10000199.hg.1	1.6497922	6.614120	4.717131	0.0027443	0.0027443	-1.2897935	BAMBI	BMP and activin membrane-bound inhibitor
TC14001728.hg.1	0.5271554	2.629286	4.286809	0.0021976	0.0021976	-1.2903411	LINC00643	long intergenic non-protein coding RNA 643
TC04000798.hg.1	0.5238122	4.428890	4.285021	0.0022033	0.0022033	-1.2929422	GLRB	glycine receptor, beta
TC0X001859.hg.1	0.8424673	6.413685	4.313611	0.0022416	0.0022416	-1.2934604	STAG2	stromal antigen 2
TC08001275.hg.1	0.5508103	3.080278	4.284369	0.0022053	0.0022053	-1.2938914	CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1
3482867_st	0.6605431	8.223876	4.284077	0.0022062	0.0022062	-1.2943163	—	—
TC02001365.hg.1	0.4780675	5.796928	4.283662	0.0022076	0.0022076	-1.2949203	DAW1	dynein assembly factor with WDR repeat domains 1
TC08000253.hg.1	0.5356741	8.786860	4.283135	0.0022092	0.0022092	-1.2956870	RNA5SP263	RNA, 5S ribosomal pseudogene 263
TC13001234.hg.1	-0.5675627	2.481833	-4.282712	0.0022106	0.0022106	-1.2963021	GPR180	G protein-coupled receptor 180
TC17001590.hg.1	0.5571342	6.589925	4.278762	0.0022231	0.0022231	-1.3020527	C1QL1	complement component 1, q subcomponent-like 1
TC17001280.hg.1	0.4412038	1.325499	4.275560	0.0022334	0.0022334	-1.3067155	—	—
TC01000314.hg.1	0.5206725	8.762052	4.275478	0.0022336	0.0022336	-1.3068363	CLIC4	chloride intracellular channel 4
TC0X001278.hg.1	0.5484884	3.947650	4.273829	0.0022389	0.0022389	-1.3092372	CHRDL1	chordin-like 1
TC06000105.hg.1	0.6421319	2.706887	4.279286	0.0022475	0.0022475	-1.3097013	RNU6-522P	RNA, U6 small nuclear 522, pseudogene
TC06002825.hg.1	0.4738093	1.650176	4.267554	0.0022592	0.0022592	-1.3183819	—	—
TC01000128.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-37P	RNA, U6 small nuclear 37, pseudogene
TC02002540.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC03000967.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC07001824.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-11P	RNA, U6 small nuclear 11, pseudogene
TC0X001437.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC14000206.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-1	RNA, U6 small nuclear 1
TC14001020.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-1	RNA, U6 small nuclear 1
TC15001590.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC19000021.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC19000026.hg.1	0.5444992	10.317502	4.266611	0.0022623	0.0022623	-1.3197570	RNU6-2	RNA, U6 small nuclear 2
TC18000609.hg.1	0.7077536	4.064311	4.276190	0.0022791	0.0022791	-1.3210448	DLGAP1-AS2	DLGAP1 antisense RNA 2
TC15000051.hg.1	0.5233408	5.704456	4.265716	0.0022652	0.0022652	-1.3210615	SNORD116-5	small nucleolar RNA, C/D box 116-5
TC15000053.hg.1	0.5233408	5.704456	4.265716	0.0022652	0.0022652	-1.3210615	SNORD116-5	small nucleolar RNA, C/D box 116-5
TC04001197.hg.1	-0.6333664	5.663708	-4.266497	0.0022677	0.0022677	-1.3215230	SCFD2	sec1 family domain containing 2
TC07002071.hg.1	1.0660588	2.985549	4.439854	0.0025004	0.0025004	-1.3219418	AC005534.8	novel transcript
TC19000216.hg.1	0.8089330	5.976167	4.289607	0.0023035	0.0023035	-1.3230811	ZNF788	zinc finger family member 788
TC16001156.hg.1	0.5251194	9.391492	4.264085	0.0022705	0.0022705	-1.3234400	SNORA76A	small nucleolar RNA, H/ACA box 76A
TC11000558.hg.1	0.5625365	4.863150	4.263219	0.0022733	0.0022733	-1.3247017	METTL12	methyltransferase like 12
TC04001459.hg.1	-0.4596678	3.928292	-4.263007	0.0022740	0.0022740	-1.3250106	LEF1	lymphoid enhancer-binding factor 1
PSR04015435.hg.1	0.8589559	8.061339	4.286648	0.0023059	0.0023059	-1.3250869	—	—
TC04001174.hg.1	0.6146818	4.332241	4.262609	0.0022753	0.0022753	-1.3255909	RNU6-838P	RNA, U6 small nuclear 838, pseudogene
TC6_mann_hap4000120.hg.1	-0.5311551	7.663016	-4.261929	0.0022775	0.0022775	-1.3265829	FLOT1	flotillin 1
TC12000747.hg.1	-0.5324176	5.836511	-4.261659	0.0022784	0.0022784	-1.3269771	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)
47423764_st	-0.8496912	2.403313	-4.330529	0.0023803	0.0023803	-1.3298045	—	—
TC01005106.hg.1	-0.5327191	2.432039	-4.259502	0.0022855	0.0022855	-1.3301242	DISC1	disrupted in schizophrenia 1
TC09001664.hg.1	0.4778560	4.176642	4.257813	0.0022911	0.0022911	-1.3325875	FAM78A	family with sequence similarity 78, member A
TC04001378.hg.1	0.5400612	10.278899	4.255629	0.0022983	0.0022983	-1.3357747	RNU6-33P	RNA, U6 small nuclear 33, pseudogene
TC08000004.hg.1	0.4966554	4.751920	4.255618	0.0022983	0.0022983	-1.3357914	LOC286161	uncharacterized LOC286161
TC21000718.hg.1	-0.4041205	1.926940	-4.254050	0.0023035	0.0023035	-1.3380794	BRWD1-AS1	putative novel transcript
TC02001601.hg.1	0.7673167	7.649917	4.259295	0.0023214	0.0023214	-1.3414268	—	—
TC14000326.hg.1	0.5931864	9.269646	4.249927	0.0023172	0.0023172	-1.3440987	KTN1	kinectin 1 (kinesin receptor)
TC0X001948.hg.1	0.5976306	8.936887	4.249894	0.0023173	0.0023173	-1.3441465	VAMP7	vesicle-associated membrane protein 7
TC6_qbl_hap6000146.hg.1	-0.5204508	8.745871	-4.249548	0.0023185	0.0023185	-1.3446528	HLA-C	major histocompatibility complex, class I, C
TC6_ssto_hap7000190.hg.1	-0.5204508	8.745871	-4.249548	0.0023185	0.0023185	-1.3446528	HLA-C	major histocompatibility complex, class I, C
TC14001727.hg.1	0.5593882	2.105624	4.250241	0.0023213	0.0023213	-1.3452260	—	—
TC18000128.hg.1	-0.5791189	8.453045	-4.248252	0.0023228	0.0023228	-1.3465446	DSG2	desmoglein 2
TC01003996.hg.1	-0.7564944	5.565902	-4.261968	0.0023438	0.0023438	-1.3471894	LYST	lysosomal trafficking regulator
TC0X000723.hg.1	0.6026043	6.411097	4.247548	0.0023252	0.0023252	-1.3475727	MTM1	myotubularin 1
TC22000039.hg.1	0.4438574	2.270291	4.246165	0.0023298	0.0023298	-1.3495937	—	—
TC03001083.hg.1	0.5932818	9.680490	4.245723	0.0023313	0.0023313	-1.3502394	RNU6-25P	RNA, U6 small nuclear 25, pseudogene
TC05003443.hg.1	-0.5174611	7.217181	-4.245059	0.0023335	0.0023335	-1.3512091	LOC100132287	uncharacterized LOC100132287
TC09001343.hg.1	1.1819089	6.813308	4.423998	0.0025839	0.0025839	-1.3517884	—	—
TC02002745.hg.1	-0.6225330	6.569838	-4.242571	0.0023419	0.0023419	-1.3548437	BARD1	BRCA1 associated RING domain 1
TC17001557.hg.1	0.5973691	7.686306	4.242312	0.0023428	0.0023428	-1.3552218	RNU2-4P	RNA, U2 small nuclear 4, pseudogene
TC0X001016.hg.1	0.5793876	9.680178	4.242152	0.0023433	0.0023433	-1.3554558	RNU6-29P	RNA, U6 small nuclear 29, pseudogene
TC10001312.hg.1	0.7685857	7.793579	4.249406	0.0023555	0.0023555	-1.3560948	IPMK	inositol polyphosphate multikinase
TC14001206.hg.1	0.6095694	7.686859	4.241440	0.0023457	0.0023457	-1.3564967	PPP2R5E	protein phosphatase 2, regulatory subunit B, epsilon isoform
TC10000827.hg.1	0.6006115	3.694167	4.241057	0.0023470	0.0023470	-1.3570561	—	—
TC04001753.hg.1	-0.6713681	5.207428	-4.246370	0.0023561	0.0023561	-1.3575560	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)
TC11001509.hg.1	0.8700386	6.186684	4.275726	0.0024122	0.0024122	-1.3620608	LGR4	leucine-rich repeat containing G protein-coupled receptor 4
TC04001128.hg.1	0.5609736	10.087809	4.237608	0.0023587	0.0023587	-1.3620985	RNU6-32P	RNA, U6 small nuclear 32, pseudogene
TC08000390.hg.1	0.5609736	10.087809	4.237608	0.0023587	0.0023587	-1.3620985	RNU6-13P	RNA, U6 small nuclear 13, pseudogene
TC08000693.hg.1	0.5609736	10.087809	4.237608	0.0023587	0.0023587	-1.3620985	RNU6-12P	RNA, U6 small nuclear 12, pseudogene
TC10002372.hg.1	0.7032875	5.381693	4.245062	0.0023702	0.0023702	-1.3624128	—	—
TC09001484.hg.1	-0.5027707	7.266127	-4.234747	0.0023684	0.0023684	-1.3662821	PTGR1	prostaglandin reductase 1
TC6_mann_hap4000022.hg.1	-0.5410139	7.284713	-4.234693	0.0023686	0.0023686	-1.3663611	HLA-A	major histocompatibility complex, class I, A
TC12002221.hg.1	0.4764091	4.880225	4.233194	0.0023737	0.0023737	-1.3685528	—	—
TC17001438.hg.1	0.4730626	10.035000	4.232629	0.0023757	0.0023757	-1.3693788	SNORA21	small nucleolar RNA, H/ACA box 21
TC18000720.hg.1	0.5471589	1.788247	4.235325	0.0023838	0.0023838	-1.3706694	—	—
TC01000005.hg.1	-0.5439152	6.558341	-4.231176	0.0023807	0.0023807	-1.3715047	LOC100132287	uncharacterized LOC100132287
TC16001604.hg.1	-0.5884032	7.699381	-4.230257	0.0023838	0.0023838	-1.3728498	CES2	carboxylesterase 2
TC07001236.hg.1	-0.4782504	5.751149	-4.229520	0.0023864	0.0023864	-1.3739269	CPVL	carboxypeptidase, vitellogenic-like
TC07001031.hg.1	0.4800458	6.439844	4.228884	0.0023885	0.0023885	-1.3748580	ACTR3B	ARP3 actin-related protein 3 homolog B (yeast)
TC06000634.hg.1	0.4298423	1.811307	4.228121	0.0023912	0.0023912	-1.3759748	—	—
TC10000099.hg.1	0.5512689	10.224638	4.227922	0.0023919	0.0023919	-1.3762653	RNU6-1	RNA, U6 small nuclear 1
TC11000580.hg.1	0.6173971	7.768939	4.227590	0.0023930	0.0023930	-1.3767522	RNU6-45P	RNA, U6 small nuclear 45, pseudogene
TC19000688.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A1	small ILF3/NF90-associated RNA A1
TC19000689.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19000691.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A1	small ILF3/NF90-associated RNA A1
TC19001731.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001732.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001733.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001734.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001735.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001736.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001737.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001738.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC19001739.hg.1	1.0801544	8.395668	4.329101	0.0025614	0.0025614	-1.3831403	SNAR-A3	small ILF3/NF90-associated RNA A3
TC10000777.hg.1	0.5782528	2.088052	4.226608	0.0024139	0.0024139	-1.3833966	—	—
TC05002903.hg.1	-0.5064019	5.381152	-4.222422	0.0024109	0.0024109	-1.3843167	—	—
TC13000419.hg.1	-0.5277424	7.376775	-4.221731	0.0024133	0.0024133	-1.3853287	CUL4A	cullin 4A
TC10001495.hg.1	0.4586438	3.771793	4.218179	0.0024257	0.0024257	-1.3905308	RNLS	renalase, FAD-dependent amine oxidase
TC05003425.hg.1	-0.5243110	7.270474	-4.218121	0.0024259	0.0024259	-1.3906149	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
TC02000756.hg.1	0.6229797	6.604259	4.215598	0.0024348	0.0024348	-1.3943112	PTPN4	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
TC14000313.hg.1	0.4640426	1.892269	4.215123	0.0024365	0.0024365	-1.3950074	—	—
TC01001805.hg.1	1.1846802	7.540767	4.379172	0.0026801	0.0026801	-1.3956530	TGFB2	transforming growth factor, beta 2
TC19002228.hg.1	0.6600115	4.392631	4.214870	0.0024629	0.0024629	-1.4028250	—	—
TC09000293.hg.1	0.5624684	4.002667	4.209291	0.0024571	0.0024571	-1.4035546	RP11-58A12.3	novel transcript
TC0X000957.hg.1	-0.4882754	5.274037	-4.209128	0.0024577	0.0024577	-1.4037941	MID1IP1-AS1	MID1IP1 antisense RNA 1
TC11000938.hg.1	0.4279433	2.183572	4.207827	0.0024623	0.0024623	-1.4057020	—	—
TC08002023.hg.1	0.8094075	4.275749	4.240128	0.0025268	0.0025268	-1.4103481	C8orf37-AS1	C8orf37 antisense RNA 1
TC02002659.hg.1	-0.5998914	5.066447	-4.204264	0.0024750	0.0024750	-1.4109262	TYW5	tRNA-yW synthesizing protein 5
TC19001666.hg.1	-0.5264199	7.665178	-4.203172	0.0024789	0.0024789	-1.4125280	NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha
TC07001768.hg.1	-0.5698458	6.933994	-4.203156	0.0024790	0.0024790	-1.4125527	LINC00998	long intergenic non-protein coding RNA 998
TC02000880.hg.1	0.8290445	6.589833	4.229139	0.0025183	0.0025183	-1.4126105	—	—
TC10001545.hg.1	0.8473565	7.941757	4.225749	0.0025140	0.0025140	-1.4128407	NOC3L	nucleolar complex associated 3 homolog (S. cerevisiae)
TC04001830.hg.1	0.7295786	4.558025	4.216064	0.0024999	0.0024999	-1.4129756	TRIML2	tripartite motif family-like 2
TC01006397.hg.1	-0.5620801	3.143369	-4.202540	0.0024812	0.0024812	-1.4134566	RP11-483I13.4	—
TC02000890.hg.1	0.6037429	2.570285	4.205037	0.0024901	0.0024901	-1.4149401	—	—
TC17001286.hg.1	0.3820376	1.381704	4.200795	0.0024875	0.0024875	-1.4160166	—	—
TC10002970.hg.1	0.5242782	6.161221	4.198459	0.0024959	0.0024959	-1.4194441	METTL10	methyltransferase like 10
TC01006180.hg.1	0.5162152	3.153986	4.198261	0.0024966	0.0024966	-1.4197352	TAF5L	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TC13000957.hg.1	0.4214450	2.253524	4.198140	0.0024970	0.0024970	-1.4199126	—	—
TC01006399.hg.1	-0.5222519	3.580334	-4.196038	0.0025046	0.0025046	-1.4229974	NBPF6	neuroblastoma breakpoint family, member 6
PSR06002933.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_cox_hap2000477.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_dbb_hap3000466.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_mann_hap4000457.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_mcf_hap5000366.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_qbl_hap6000463.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
PSR6_ssto_hap7000460.hg.1	-0.5025102	9.732514	-4.192044	0.0025192	0.0025192	-1.4288610	—	—
TC19000509.hg.1	0.6350951	5.756900	4.192568	0.0025271	0.0025271	-1.4308928	ZNF568	zinc finger protein 568
TC04001380.hg.1	-0.5040523	5.098065	-4.190288	0.0025256	0.0025256	-1.4314402	FAM13A	family with sequence similarity 13, member A
TC0X000742.hg.1	0.5764257	7.384921	4.189571	0.0025282	0.0025282	-1.4324941	CSAG2	CSAG family, member 2
PSR02018287.hg.1	-0.6686834	6.689725	-4.190141	0.0025379	0.0025379	-1.4349896	—	—
TC10000863.hg.1	0.5062945	7.189306	4.185438	0.0025434	0.0025434	-1.4385664	FAM45A	family with sequence similarity 45, member A
PSR06002927.hg.1	-0.4667415	9.941580	-4.185398	0.0025435	0.0025435	-1.4386243	—	—
PSR01050550.hg.1	0.7352613	7.455497	4.190902	0.0025552	0.0025552	-1.4394979	—	—
TC17000528.hg.1	-0.5902457	7.735689	-4.180475	0.0025617	0.0025617	-1.4458610	HSD17B1	hydroxysteroid (17-beta) dehydrogenase 1
TC13000585.hg.1	-0.5045893	6.854606	-4.180333	0.0025623	0.0025623	-1.4460695	LHFP	lipoma HMGIC fusion partner
TC12000757.hg.1	0.5422262	10.273005	4.180307	0.0025624	0.0025624	-1.4461071	RNU6-36P	RNA, U6 small nuclear 36, pseudogene
TC01001404.hg.1	0.6710602	7.728195	4.175606	0.0025815	0.0025815	-1.4534615	—	—
TC07000625.hg.1	-0.6483560	7.315183	-4.174433	0.0025843	0.0025843	-1.4547452	AGFG2	ArfGAP with FG repeats 2
TC11002283.hg.1	0.7764338	2.649174	4.210716	0.0026434	0.0026434	-1.4551259	—	—
TC05001554.hg.1	0.6486152	4.916614	4.177978	0.0025920	0.0025920	-1.4553309	SCARNA18	small Cajal body-specific RNA 18
TC16001177.hg.1	0.9953274	5.962884	4.276179	0.0027502	0.0027502	-1.4557955	RRAD	Ras-related associated with diabetes
TC06003348.hg.1	-0.4474827	1.914736	-4.171339	0.0025959	0.0025959	-1.4592977	—	—
TC20000106.hg.1	0.6292241	8.320816	4.170666	0.0025984	0.0025984	-1.4602881	RNU6-27P	RNA, U6 small nuclear 27, pseudogene
TC13000833.hg.1	0.5110949	4.772705	4.170490	0.0025991	0.0025991	-1.4605476	RNY3P6	RNA, Ro-associated Y3 pseudogene 6
TC11001454.hg.1	0.6082497	8.701813	4.168687	0.0026059	0.0026059	-1.4632002	SNORD14B	small nucleolar RNA, C/D box 14B
TC07000582.hg.1	-0.4708202	6.771484	-4.166276	0.0026150	0.0026150	-1.4667503	LMTK2	lemur tyrosine kinase 2
TC12002262.hg.1	0.5731448	5.166787	4.166068	0.0026158	0.0026158	-1.4670563	ATF7IP	activating transcription factor 7 interacting protein
TC07002041.hg.1	-0.4872179	5.933711	-4.165967	0.0026162	0.0026162	-1.4672045	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
TC17000132.hg.1	0.6711123	5.942167	4.170255	0.0026235	0.0026235	-1.4673033	MIR4521	microRNA 4521
TC0X001937.hg.1	0.6221087	7.580636	4.164514	0.0026217	0.0026217	-1.4693431	ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1
TC08001654.hg.1	-0.5731325	5.175722	-4.162174	0.0026307	0.0026307	-1.4727888	LRRC6	leucine rich repeat containing 6
TC10001182.hg.1	-0.5059692	7.022658	-4.162037	0.0026312	0.0026312	-1.4729912	NAMPTL	nicotinamide phosphoribosyltransferase-like
TC06001108.hg.1	-0.5395306	1.400466	-4.167823	0.0026418	0.0026418	-1.4733159	RP11-133I21.2	novel transcript, antisense to SYNE1
TC20000170.hg.1	-0.3742782	1.373896	-4.159382	0.0026413	0.0026413	-1.4769016	RNU6ATAC17P	RNA, U6atac small nuclear 17, pseudogene
TC14001410.hg.1	-0.5673035	2.104639	-4.162414	0.0026484	0.0026484	-1.4774606	—	—
TC04000462.hg.1	-0.7299349	5.659314	-4.169734	0.0026660	0.0026660	-1.4789526	CDS1	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
TC09000606.hg.1	0.5626845	5.092547	4.157982	0.0026467	0.0026467	-1.4789645	PSMD5-AS1	PSMD5 antisense RNA 1 (head to head)
TC10000298.hg.1	0.4778095	6.688113	4.157980	0.0026467	0.0026467	-1.4789674	FAM35BP	family with sequence similarity 35, member A pseudogene
TC6_cox_hap2000245.hg.1	0.5176199	6.150349	4.157883	0.0026471	0.0026471	-1.4791106	CFB	complement factor B
TC14000525.hg.1	-0.5900586	2.878680	-4.158775	0.0026493	0.0026493	-1.4793040	—	—
TC0X000644.hg.1	0.8190936	7.024495	4.179202	0.0026865	0.0026865	-1.4802768	SMIM10	small integral membrane protein 10
PSR6_cox_hap2000476.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
PSR6_dbb_hap3000465.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
PSR6_mann_hap4000456.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
PSR6_mcf_hap5000365.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
PSR6_qbl_hap6000462.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
PSR6_ssto_hap7000459.hg.1	-0.4554535	9.846163	-4.156189	0.0026536	0.0026536	-1.4816063	—	—
TC0X000588.hg.1	0.5523851	2.011927	4.158080	0.0026651	0.0026651	-1.4838327	SOWAHD	sosondowah ankyrin repeat domain family member D
TC06001152.hg.1	-0.5118564	8.209315	-4.154557	0.0026599	0.0026599	-1.4840123	IGF2R	insulin-like growth factor 2 receptor
TC07002009.hg.1	0.6454857	3.355434	4.158336	0.0026709	0.0026709	-1.4852718	—	—
TC01006192.hg.1	0.6008028	8.433337	4.153048	0.0026658	0.0026658	-1.4862358	EGLN1	egl-9 family hypoxia-inducible factor 1
TC09002166.hg.1	0.4714363	5.416857	4.152396	0.0026683	0.0026683	-1.4871971	—	—
TC15000560.hg.1	-0.8147452	2.564385	-4.208779	0.0027629	0.0027629	-1.4874550	—	—
TC14001364.hg.1	0.6597222	8.248874	4.151155	0.0026731	0.0026731	-1.4890265	DIO2	deiodinase, iodothyronine, type II
TC0X000381.hg.1	0.4907696	5.915318	4.149883	0.0026781	0.0026781	-1.4909011	FOXO4	forkhead box O4
TC01003555.hg.1	-0.4442895	2.848203	-4.149105	0.0026811	0.0026811	-1.4920485	PTP4A1P7	protein tyrosine phosphatase type IVA, member 1 pseudogene 7
TC06001655.hg.1	-0.5922435	6.539043	-4.147416	0.0026877	0.0026877	-1.4945393	—	—
TC04001397.hg.1	0.5206552	9.186134	4.147152	0.0026887	0.0026887	-1.4949287	RNU6-34P	RNA, U6 small nuclear 34, pseudogene
TC18000964.hg.1	0.6969768	4.279972	4.155520	0.0027111	0.0027111	-1.4971233	—	—
TC02003574.hg.1	-0.5515498	5.312775	-4.145063	0.0026969	0.0026969	-1.4980108	—	—
TC0X001342.hg.1	0.8751229	7.060050	4.178977	0.0027550	0.0027550	-1.4982753	THOC2	THO complex 2
TC06000525.hg.1	-0.4929149	6.035263	-4.144117	0.0027006	0.0027006	-1.4994063	BRPF3	bromodomain and PHD finger containing, 3
TC15001437.hg.1	0.5425979	2.965237	4.143836	0.0027017	0.0027017	-1.4998212	—	—
TC01004802.hg.1	0.6560839	7.688163	4.143025	0.0027049	0.0027049	-1.5010179	DDR2	discoidin domain receptor tyrosine kinase 2
TC05000096.hg.1	-0.5144355	8.571840	-4.142651	0.0027064	0.0027064	-1.5015687	BASP1	brain abundant, membrane attached signal protein 1
TC0X001429.hg.1	0.7264664	8.111793	4.147704	0.0027169	0.0027169	-1.5020842	ATP11C	ATPase, class VI, type 11C
TC09002234.hg.1	0.6322092	4.881664	4.145172	0.0027154	0.0027154	-1.5028260	PSMD5-AS1	PSMD5 antisense RNA 1 (head to head)
TC02001035.hg.1	-0.4904104	6.046810	-4.139492	0.0027188	0.0027188	-1.5062314	CDCA7	cell division cycle associated 7
TC20000873.hg.1	0.4381482	3.960330	4.139432	0.0027191	0.0027191	-1.5063187	KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
TC11000752.hg.1	0.4653703	5.158260	4.136662	0.0027301	0.0027301	-1.5104081	—	—
TC06001387.hg.1	0.7045209	10.044436	4.143283	0.0027446	0.0027446	-1.5112276	HIST1H2BK	histone cluster 1, H2bk
TC05001184.hg.1	-0.4630606	3.916470	-4.136019	0.0027326	0.0027326	-1.5113576	MYO10	myosin X
TC13001260.hg.1	-0.7593538	5.997155	-4.152424	0.0027645	0.0027645	-1.5123397	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
TC14001773.hg.1	0.6572805	3.708249	4.141232	0.0027455	0.0027455	-1.5123750	NEK9	NIMA-related kinase 9
TC12000386.hg.1	0.4644558	5.747723	4.134578	0.0027384	0.0027384	-1.5134854	ASIC1	acid-sensing (proton-gated) ion channel 1
3672413_st	0.8289782	5.237188	4.171906	0.0028059	0.0028059	-1.5143470	—	—
3530228_st	0.5075956	10.272533	4.133945	0.0027409	0.0027409	-1.5144195	—	—
TC06001962.hg.1	-0.4630187	4.992368	-4.132513	0.0027466	0.0027466	-1.5165340	FAXC	failed axon connections homolog (Drosophila)
TC02000115.hg.1	0.4645230	3.510374	4.131282	0.0027515	0.0027515	-1.5183534	RNU6-961P	RNA, U6 small nuclear 961, pseudogene
TC20001462.hg.1	0.6795459	3.833991	4.137983	0.0027657	0.0027657	-1.5190178	—	—
TC08001683.hg.1	-0.4895969	6.766000	-4.129954	0.0027569	0.0027569	-1.5203144	CASC7	cancer susceptibility candidate 7 (non-protein coding)
TC02002674.hg.1	-0.7160161	7.669204	-4.133617	0.0027684	0.0027684	-1.5216370	TRAK2	trafficking protein, kinesin binding 2
TC19001924.hg.1	0.4420158	4.852922	4.129056	0.0027605	0.0027605	-1.5216410	MZF1	myeloid zinc finger 1
TC10001324.hg.1	0.7415270	7.076027	4.136632	0.0027751	0.0027751	-1.5220127	RTKN2	rhotekin 2
TC07002716.hg.1	0.7259438	5.509474	4.141012	0.0027829	0.0027829	-1.5220673	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6
PSR14010167.hg.1	0.5527237	10.398795	4.128709	0.0027619	0.0027619	-1.5221535	—	—
TC01001951.hg.1	0.5188283	5.825171	4.127974	0.0027648	0.0027648	-1.5232395	RNU2-70P	RNA, U2 small nuclear 70, pseudogene
TC10000869.hg.1	0.6029610	5.646714	4.127294	0.0027676	0.0027676	-1.5242453	INPP5F	inositol polyphosphate-5-phosphatase F
PSR11018238.hg.1	0.5073448	9.744561	4.126771	0.0027697	0.0027697	-1.5250183	—	—
TC01004042.hg.1	0.7314931	2.497219	4.156731	0.0028281	0.0028281	-1.5265808	RP11-370K11.1	novel transcript
TC08002443.hg.1	0.6543734	4.823568	4.131540	0.0027843	0.0027843	-1.5266356	—	—
TC13000733.hg.1	-0.6023958	4.940531	-4.122204	0.0027940	0.0027940	-1.5332447	KLF12	Kruppel-like factor 12
TC07002575.hg.1	-0.6173511	7.958862	-4.120168	0.0027965	0.0027965	-1.5347781	LINC01000	long intergenic non-protein coding RNA 1000
TC17000661.hg.1	0.6386121	4.370215	4.123681	0.0028044	0.0028044	-1.5352075	LOC101927230	uncharacterized LOC101927230
TC6_mcf_hap5000213.hg.1	0.5117579	6.147923	4.119338	0.0027998	0.0027998	-1.5360050	CFB	complement factor B
TC6_ssto_hap7000199.hg.1	0.5117579	6.147923	4.119338	0.0027998	0.0027998	-1.5360050	CFB	complement factor B
TC10000698.hg.1	0.6335375	6.514937	4.119331	0.0027999	0.0027999	-1.5360156	ANKRD2	ankyrin repeat domain 2 (stretch responsive muscle)
TC0Y000261.hg.1	0.7099236	6.201355	4.126411	0.0028190	0.0028190	-1.5376678	—	—
TC19000864.hg.1	0.6165545	4.486117	4.117999	0.0028222	0.0028222	-1.5422262	AC008440.10	putative novel transcript
TC6_ssto_hap7000016.hg.1	-0.5218902	6.781241	-4.112786	0.0028267	0.0028267	-1.5456978	HLA-F	major histocompatibility complex, class I, F
TC0X001358.hg.1	0.5120844	7.523413	4.112730	0.0028270	0.0028270	-1.5457793	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1
TCUn_gl000222000005.hg.1	0.5646580	5.769654	4.112701	0.0028271	0.0028271	-1.5458232	—	—
TC08002594.hg.1	0.4848492	4.480786	4.112032	0.0028298	0.0028298	-1.5468132	FAM66D	family with sequence similarity 66, member D
TC01003692.hg.1	-0.4949567	8.214408	-4.111637	0.0028315	0.0028315	-1.5473967	CSRP1	cysteine and glycine-rich protein 1
TC0X000572.hg.1	0.5507702	7.276284	4.111426	0.0028323	0.0028323	-1.5477099	WDR44	WD repeat domain 44
TC20000747.hg.1	0.4911104	2.640115	4.110415	0.0028365	0.0028365	-1.5492056	MLLT10P1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 pseudogene 1
TC11000878.hg.1	0.5194387	7.224328	4.110131	0.0028377	0.0028377	-1.5496266	TMEM135	transmembrane protein 135
TC14001098.hg.1	0.4725226	9.391685	4.109908	0.0028386	0.0028386	-1.5499566	RPS29	ribosomal protein S29
TC19002544.hg.1	-0.5209472	7.251256	-4.108920	0.0028427	0.0028427	-1.5514179	—	—
TC11000178.hg.1	0.6046794	5.678632	4.108881	0.0028429	0.0028429	-1.5514758	SBF2-AS1	SBF2 antisense RNA 1
TC08001737.hg.1	-0.5698517	7.159663	-4.108526	0.0028444	0.0028444	-1.5520011	PLEC	plectin
TC09000737.hg.1	1.0631138	7.526576	4.216259	0.0030446	0.0030446	-1.5532558	—	—
TC22000672.hg.1	0.5348594	6.239126	4.107226	0.0028498	0.0028498	-1.5539263	RNU6-28P	RNA, U6 small nuclear 28, pseudogene
TC15001156.hg.1	0.6347455	4.284779	4.110804	0.0028574	0.0028574	-1.5542107	—	—
TC03001625.hg.1	0.5615213	5.528032	4.106741	0.0028518	0.0028518	-1.5546445	LINC00882	long intergenic non-protein coding RNA 882
TC08001483.hg.1	0.4996289	3.213875	4.106562	0.0028525	0.0028525	-1.5549094	—	—
TC15000913.hg.1	0.4141913	1.370365	4.105273	0.0028579	0.0028579	-1.5568177	—	—
TC01001425.hg.1	0.7518803	7.513222	4.113927	0.0028782	0.0028782	-1.5579372	DDR2	discoidin domain receptor tyrosine kinase 2
TC17000551.hg.1	0.5192164	6.971147	4.102478	0.0028696	0.0028696	-1.5609572	ARL4D	ADP-ribosylation factor-like 4D
TC07001024.hg.1	0.5184440	6.452179	4.101368	0.0028742	0.0028742	-1.5626011	GALNT11	polypeptide N-acetylgalactosaminyltransferase 11
TC19001816.hg.1	-0.4319928	1.911459	-4.100905	0.0028762	0.0028762	-1.5632870	VN1R4	vomeronasal 1 receptor 4
47421241_st	-0.9641819	2.656520	-4.240567	0.0031336	0.0031336	-1.5634868	—	—
TC12002066.hg.1	0.7143736	4.983985	4.112793	0.0029007	0.0029007	-1.5639383	HPD	4-hydroxyphenylpyruvate dioxygenase
TC12001883.hg.1	0.6885859	4.683396	4.108845	0.0029005	0.0029005	-1.5656764	RNU6-1183P	RNA, U6 small nuclear 1183, pseudogene
TC6_dbb_hap3000222.hg.1	0.5101645	6.149681	4.099019	0.0028841	0.0028841	-1.5660805	CFB	complement factor B
TC13000442.hg.1	0.5482248	7.994644	4.097795	0.0028893	0.0028893	-1.5678942	—	—
TC21000279.hg.1	0.5482248	7.994644	4.097795	0.0028893	0.0028893	-1.5678942	—	—
TC02003773.hg.1	-0.6893157	6.923546	-4.098763	0.0029080	0.0029080	-1.5720018	NBEAL1	neurobeachin-like 1
TC17002001.hg.1	0.7440987	7.838442	4.101186	0.0029174	0.0029174	-1.5732084	PITPNA-AS1	PITPNA antisense RNA 1
PSR19013250.hg.1	0.4496898	10.791123	4.094008	0.0029053	0.0029053	-1.5735070	—	—
TC20000419.hg.1	0.5224468	3.106393	4.093634	0.0029069	0.0029069	-1.5740618	—	—
TC19000164.hg.1	0.5277565	7.624147	4.093502	0.0029075	0.0029075	-1.5742567	UBL5	ubiquitin-like 5
TC03001274.hg.1	-0.4875424	5.266915	-4.092719	0.0029108	0.0029108	-1.5754171	SUSD5	sushi domain containing 5
TC01006362.hg.1	-0.4336864	2.924577	-4.092607	0.0029113	0.0029113	-1.5755839	GBP7	guanylate binding protein 7
TC06004066.hg.1	-0.4987248	7.015385	-4.092393	0.0029122	0.0029122	-1.5759003	HLA-H	major histocompatibility complex, class I, H (pseudogene)
TC6_cox_hap2000020.hg.1	-0.5171608	6.448678	-4.091808	0.0029147	0.0029147	-1.5767681	HLA-F	major histocompatibility complex, class I, F
TC04000702.hg.1	-0.4494943	4.126904	-4.090674	0.0029195	0.0029195	-1.5784495	GUSBP5	glucuronidase, beta pseudogene 5
TC19002056.hg.1	0.6441917	6.332593	4.092501	0.0029248	0.0029248	-1.5788935	—	—
TC6_qbl_hap6000225.hg.1	0.5100883	6.150726	4.090370	0.0029208	0.0029208	-1.5788994	CFB	complement factor B
TC05001277.hg.1	0.4880833	4.390921	4.089868	0.0029230	0.0029230	-1.5796445	RNU6-1190P	RNA, U6 small nuclear 1190, pseudogene
TC15000015.hg.1	0.5413497	8.019610	4.088335	0.0029295	0.0029295	-1.5819187	—	—
TC03002028.hg.1	0.5773694	3.376000	4.088002	0.0029310	0.0029310	-1.5824113	—	—
TC18000992.hg.1	0.5154144	2.871548	4.087581	0.0029328	0.0029328	-1.5830367	—	—
TC06004077.hg.1	0.4963358	6.075330	4.085696	0.0029409	0.0029409	-1.5858323	CFB	complement factor B
TC06001631.hg.1	-0.4923998	2.888132	-4.084994	0.0029439	0.0029439	-1.5868728	—	—
TC06000375.hg.1	0.8888709	7.196094	4.119446	0.0030173	0.0030173	-1.5887998	SNORA38	small nucleolar RNA, H/ACA box 38
TC6_cox_hap2000071.hg.1	0.8888709	7.196094	4.119446	0.0030173	0.0030173	-1.5887998	SNORA38	small nucleolar RNA, H/ACA box 38
TC6_mann_hap4000062.hg.1	0.8888709	7.196094	4.119446	0.0030173	0.0030173	-1.5887998	SNORA38	small nucleolar RNA, H/ACA box 38
TC6_qbl_hap6000062.hg.1	0.8888709	7.196094	4.119446	0.0030173	0.0030173	-1.5887998	SNORA38	small nucleolar RNA, H/ACA box 38
TC6_ssto_hap7000058.hg.1	0.8888709	7.196094	4.119446	0.0030173	0.0030173	-1.5887998	SNORA38	small nucleolar RNA, H/ACA box 38
TC04001818.hg.1	0.4663663	5.169291	4.083037	0.0029523	0.0029523	-1.5897774	CCDC110	coiled-coil domain containing 110
TC22000925.hg.1	0.6086237	5.224510	4.084306	0.0029579	0.0029579	-1.5905275	—	—
TC08002551.hg.1	-0.5224580	7.065517	-4.082129	0.0029562	0.0029562	-1.5911248	—	—
TC02001229.hg.1	-0.5360070	6.284911	-4.082005	0.0029568	0.0029568	-1.5913084	CREB1	cAMP responsive element binding protein 1
TC01003622.hg.1	0.5096284	3.691594	4.081971	0.0029569	0.0029569	-1.5913590	—	—
TC07003064.hg.1	0.9827913	8.760682	4.155580	0.0030990	0.0030990	-1.5917872	TFPI2	tissue factor pathway inhibitor 2
TC0Y000085.hg.1	0.8117075	5.230907	4.116888	0.0030255	0.0030255	-1.5918534	—	—
TC0Y000220.hg.1	0.8117075	5.230907	4.116888	0.0030255	0.0030255	-1.5918534	—	—
TC07001147.hg.1	-0.5006572	5.542767	-4.081268	0.0029600	0.0029600	-1.5924018	VWDE	von Willebrand factor D and EGF domains
TC11000611.hg.1	-0.4995209	6.636216	-4.080679	0.0029625	0.0029625	-1.5932760	PPP2R5B	protein phosphatase 2, regulatory subunit B, beta
TC03000487.hg.1	-0.4701158	1.504861	-4.077309	0.0029772	0.0029772	-1.5982793	OR5H6	olfactory receptor, family 5, subfamily H, member 6
TC07000536.hg.1	-0.5281243	5.380123	-4.075928	0.0029832	0.0029832	-1.6003280	STEAP1	six transmembrane epithelial antigen of the prostate 1
TC11002894.hg.1	-0.6876403	4.978581	-4.085303	0.0030014	0.0030014	-1.6003697	TAGLN	transgelin
TC07000550.hg.1	-0.6274019	2.981604	-4.080822	0.0029943	0.0029943	-1.6007312	MGC16142	uncharacterized protein MGC16142
TC16000172.hg.1	0.5241349	1.785566	4.078602	0.0029918	0.0029918	-1.6011469	—	—
TC14002299.hg.1	0.6699010	7.069758	4.076594	0.0030006	0.0030006	-1.6041224	CHURC1	churchill domain containing 1
TC01001771.hg.1	0.6261969	6.110800	4.070931	0.0030163	0.0030163	-1.6103620	PPP2R5A	protein phosphatase 2, regulatory subunit B, alpha
TC16000378.hg.1	-0.5275864	5.644459	-4.068998	0.0030136	0.0030136	-1.6106216	TGFB1I1	transforming growth factor beta 1 induced transcript 1
TC05002657.hg.1	-0.3787849	1.981722	-4.068742	0.0030148	0.0030148	-1.6110015	—	—
TC04000720.hg.1	-0.5044949	2.849651	-4.068604	0.0030154	0.0030154	-1.6112064	—	—
TC19002608.hg.1	-0.4899756	7.750758	-4.068283	0.0030168	0.0030168	-1.6116840	NUP62	nucleoporin 62kDa
TC14001681.hg.1	0.5191847	3.553937	4.067848	0.0030187	0.0030187	-1.6123307	—	—
TC22000008.hg.1	0.5658729	4.812123	4.067088	0.0030221	0.0030221	-1.6134603	LA16c-2F2.8	novel transcript
TC14001636.hg.1	0.7362867	7.739448	4.073633	0.0030369	0.0030369	-1.6139097	ARHGAP5	Rho GTPase activating protein 5
TC04002945.hg.1	0.5569415	7.632477	4.066541	0.0030245	0.0030245	-1.6142719	HSD17B11	hydroxysteroid (17-beta) dehydrogenase 11
TC10001443.hg.1	-0.6235576	3.773911	-4.069304	0.0030328	0.0030328	-1.6149284	—	—
TC20001126.hg.1	0.4715646	6.713255	4.065631	0.0030286	0.0030286	-1.6156247	LINC00493	long intergenic non-protein coding RNA 493
TC13000752.hg.1	0.4451128	2.276435	4.063671	0.0030373	0.0030373	-1.6185373	RNY3P3	RNA, Ro-associated Y3 pseudogene 3
TC07000643.hg.1	-1.0683338	8.341074	-4.175697	0.0032597	0.0032597	-1.6187798	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
TC06002871.hg.1	1.1381367	5.414002	4.264213	0.0034366	0.0034366	-1.6190795	—	—
TC0X000213.hg.1	0.6911384	4.248413	4.073045	0.0030588	0.0030588	-1.6192422	RNU6-523P	RNA, U6 small nuclear 523, pseudogene
TC17001281.hg.1	2.1259749	2.507680	4.812158	0.0045164	0.0045164	-1.6198059	—	—
TC01003342.hg.1	0.5637069	5.121756	4.062359	0.0030431	0.0030431	-1.6204889	—	—
TC09001133.hg.1	0.4338531	4.271119	4.062209	0.0030438	0.0030438	-1.6207106	—	—
TC13000717.hg.1	-0.4429584	3.011238	-4.060603	0.0030510	0.0030510	-1.6230996	PCDH9	protocadherin 9
TC07000304.hg.1	0.4410465	4.190440	4.060085	0.0030533	0.0030533	-1.6238684	LINC00525	long intergenic non-protein coding RNA 525
TC15001153.hg.1	0.5634778	7.337381	4.059523	0.0030558	0.0030558	-1.6247046	—	—
TC0X002205.hg.1	-0.3776032	1.987726	-4.059370	0.0030565	0.0030565	-1.6249328	—	—
TC02002574.hg.1	-0.4817427	5.082342	-4.058869	0.0030587	0.0030587	-1.6256774	FKBP7	FK506 binding protein 7
TC01002510.hg.1	0.4855851	4.899369	4.058747	0.0030593	0.0030593	-1.6258593	—	—
TC0X001867.hg.1	0.4567067	6.180947	4.058099	0.0030622	0.0030622	-1.6268219	—	—
TC07001860.hg.1	-0.4912291	5.651064	-4.057353	0.0030655	0.0030655	-1.6279327	ZC3HC1	zinc finger, C3HC-type containing 1
PSR16011591.hg.1	0.6726156	6.533406	4.060924	0.0030732	0.0030732	-1.6280585	—	—
TC6_mcf_hap5000206.hg.1	-0.5050441	9.295846	-4.056908	0.0030675	0.0030675	-1.6285941	HLA-A	major histocompatibility complex, class I, A
TC05002338.hg.1	-0.3847607	1.564518	-4.055689	0.0030730	0.0030730	-1.6304065	—	—
TC6_ssto_hap7000217.hg.1	-0.5032553	7.548788	-4.055094	0.0030757	0.0030757	-1.6312916	HLA-H	major histocompatibility complex, class I, H (pseudogene)
TC08001313.hg.1	0.5377402	7.412069	4.053456	0.0030831	0.0030831	-1.6337292	LACTB2	lactamase, beta 2
TC14001103.hg.1	0.4821585	5.611046	4.052037	0.0030895	0.0030895	-1.6358410	DNAAF2	dynein, axonemal, assembly factor 2
TC04001496.hg.1	-0.6146823	5.980843	-4.052728	0.0030927	0.0030927	-1.6362304	SEC24D	SEC24 family member D
TC06002402.hg.1	-0.5183161	5.563068	-4.050763	0.0030953	0.0030953	-1.6377370	FOXC1	forkhead box C1
TC02001086.hg.1	-0.4522802	6.486537	-4.050710	0.0030956	0.0030956	-1.6378148	SSFA2	sperm specific antigen 2
TC01001964.hg.1	0.4573166	3.370086	4.050200	0.0030979	0.0030979	-1.6385748	CHRM3	cholinergic receptor, muscarinic 3
TC11002159.hg.1	0.4396616	3.383779	4.049619	0.0031005	0.0031005	-1.6394392	DLG2	discs, large homolog 2 (Drosophila)
TC17001768.hg.1	0.5317497	7.242264	4.049081	0.0031030	0.0031030	-1.6402395	NACA2	nascent polypeptide-associated complex alpha subunit 2
TC05003354.hg.1	0.5297562	9.850000	4.048200	0.0031070	0.0031070	-1.6415517	—	—
TC11001009.hg.1	0.5153332	6.949442	4.047514	0.0031101	0.0031101	-1.6425725	PTS	6-pyruvoyltetrahydropterin synthase
TC06000323.hg.1	-0.4991749	6.365833	-4.046179	0.0031162	0.0031162	-1.6445600	HLA-F	major histocompatibility complex, class I, F
TC01002426.hg.1	0.5404200	10.035593	4.045742	0.0031182	0.0031182	-1.6452110	SNORD99	small nucleolar RNA, C/D box 99
TC0X000762.hg.1	0.5845260	6.071132	4.044598	0.0031235	0.0031235	-1.6469144	TMEM187	transmembrane protein 187
TC06004110.hg.1	-0.4700695	6.712578	-4.044505	0.0031239	0.0031239	-1.6470528	BLOC1S5	biogenesis of lysosomal organelles complex-1, subunit 5, muted
TC09000257.hg.1	0.4415386	3.928362	4.044428	0.0031243	0.0031243	-1.6471663	—	—
TC09000282.hg.1	0.4415386	3.928362	4.044428	0.0031243	0.0031243	-1.6471663	—	—
TC09001128.hg.1	0.4415386	3.928362	4.044428	0.0031243	0.0031243	-1.6471663	—	—
TC09001131.hg.1	0.4415386	3.928362	4.044428	0.0031243	0.0031243	-1.6471663	—	—
TC01006371.hg.1	0.4440120	6.180963	4.039908	0.0031451	0.0031451	-1.6538986	VPS72	vacuolar protein sorting 72 homolog (S. cerevisiae)
TC04002199.hg.1	-0.4791439	2.422229	-4.039276	0.0031480	0.0031480	-1.6548397	—	—
TC22000965.hg.1	0.4333325	2.315445	4.038218	0.0031529	0.0031529	-1.6564174	—	—
TC01001150.hg.1	-0.4545647	4.512076	-4.037162	0.0031578	0.0031578	-1.6579896	RP11-763B22.6	novel transcript
TC03002115.hg.1	-0.4509944	3.026795	-4.037120	0.0031580	0.0031580	-1.6580532	FGF12	fibroblast growth factor 12
TC10001288.hg.1	0.4805788	6.273487	4.037094	0.0031581	0.0031581	-1.6580914	SGMS1	sphingomyelin synthase 1
TC0X000496.hg.1	0.4754705	6.995675	4.036248	0.0031620	0.0031620	-1.6593515	NGFRAP1	nerve growth factor receptor (TNFRSF16) associated protein 1
TC01004790.hg.1	0.5329517	7.558274	4.036148	0.0031625	0.0031625	-1.6595012	—	—
TC15000569.hg.1	-0.6228683	4.935691	-4.039262	0.0031718	0.0031718	-1.6601263	—	—
TC06002148.hg.1	0.4581467	3.464069	4.035483	0.0031656	0.0031656	-1.6604915	—	—
TC01002954.hg.1	0.5963070	7.637615	4.034369	0.0031708	0.0031708	-1.6621527	SORT1	sortilin 1
TC18000631.hg.1	-0.4773615	2.042162	-4.033724	0.0031738	0.0031738	-1.6631131	—	—
TC03001108.hg.1	-0.5599957	7.387081	-4.033658	0.0031741	0.0031741	-1.6632118	—	—
TC07002016.hg.1	0.5608563	5.983082	4.033295	0.0031758	0.0031758	-1.6637534	RARRES2	retinoic acid receptor responder (tazarotene induced) 2
TC01001143.hg.1	0.6336293	8.092479	4.032879	0.0031777	0.0031777	-1.6643724	—	—
TC01003428.hg.1	0.6336293	8.092479	4.032879	0.0031777	0.0031777	-1.6643724	—	—
TC13000535.hg.1	0.6336293	8.092479	4.032879	0.0031777	0.0031777	-1.6643724	—	—
TC17001431.hg.1	0.6336293	8.092479	4.032879	0.0031777	0.0031777	-1.6643724	—	—
PSR18005239.hg.1	0.9272466	8.048037	4.082114	0.0032912	0.0032912	-1.6665551	—	—
47423307_st	0.6846315	1.589235	4.070956	0.0032909	0.0032909	-1.6715070	—	—
PSR09016023.hg.1	0.4609691	10.193881	4.026411	0.0032081	0.0032081	-1.6740169	—	—
TC10000358.hg.1	0.5730307	6.886295	4.023984	0.0032196	0.0032196	-1.6776384	CISD1	CDGSH iron sulfur domain 1
TC01005193.hg.1	-0.5656383	7.419833	-4.022167	0.0032282	0.0032282	-1.6803489	RP11-206L10.3	novel transcript
TC22000922.hg.1	-0.4411614	5.321543	-4.021966	0.0032292	0.0032292	-1.6806486	RABL2B	RAB, member of RAS oncogene family-like 2B
TC02003807.hg.1	-0.5391961	8.732191	-4.021651	0.0032307	0.0032307	-1.6811188	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
TC19002169.hg.1	-0.4926697	9.005079	-4.020169	0.0032377	0.0032377	-1.6833306	CLPTM1	cleft lip and palate associated transmembrane protein 1
TC14000031.hg.1	0.6080322	5.896505	4.019291	0.0032484	0.0032484	-1.6860293	—	—
TC03002963.hg.1	0.4734065	3.035803	4.016803	0.0032538	0.0032538	-1.6883547	—	—
TC13000868.hg.1	-0.5003181	2.219393	-4.016673	0.0032544	0.0032544	-1.6885478	RNA5SP39	RNA, 5S ribosomal pseudogene 39
TC02000859.hg.1	0.7883393	7.172191	4.033376	0.0032911	0.0032911	-1.6886594	—	—
TC22000444.hg.1	0.7883393	7.172191	4.033376	0.0032911	0.0032911	-1.6886594	—	—
TC14000316.hg.1	0.4987857	8.916136	4.016569	0.0032549	0.0032549	-1.6887034	CDKN3	cyclin-dependent kinase inhibitor 3
TC19001598.hg.1	0.5188609	3.160995	4.015492	0.0032601	0.0032601	-1.6903121	ZNF404	zinc finger protein 404
TC02004020.hg.1	-0.4238136	2.765899	-4.014552	0.0032646	0.0032646	-1.6917145	—	—
TC16000524.hg.1	-0.5516285	7.543912	-4.014534	0.0032647	0.0032647	-1.6917420	CES2	carboxylesterase 2
TC15001483.hg.1	0.7359582	4.198165	4.035682	0.0033123	0.0033123	-1.6920911	LOC101928694	uncharacterized LOC101928694
TC10001360.hg.1	0.4764250	5.567030	4.012734	0.0032734	0.0032734	-1.6944298	TYSND1	trypsin domain containing 1
TC10000532.hg.1	0.6142460	2.157436	4.021942	0.0032956	0.0032956	-1.6948773	—	—
TC0X000047.hg.1	0.4656805	1.724592	4.011029	0.0032816	0.0032816	-1.6969762	—	—
TC0X000330.hg.1	-0.4951271	5.928163	-4.010769	0.0032829	0.0032829	-1.6973648	RP11-382F24.2	novel transcript
TC02001246.hg.1	-0.4480138	4.443057	-4.010147	0.0032859	0.0032859	-1.6982935	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
TC0X001223.hg.1	0.5777407	9.060403	4.009394	0.0032895	0.0032895	-1.6994186	RNU6-30P	RNA, U6 small nuclear 30, pseudogene
TC02002668.hg.1	-0.5139257	6.267625	-4.009058	0.0032911	0.0032911	-1.6999200	PPIL3	peptidylprolyl isomerase (cyclophilin)-like 3
TC0X001484.hg.1	0.4562619	6.256567	4.007083	0.0033007	0.0033007	-1.7028705	CXorf40B	chromosome X open reading frame 40B
TC19001584.hg.1	-0.4440267	10.772035	-4.006034	0.0033059	0.0033059	-1.7044380	PSG9	pregnancy specific beta-1-glycoprotein 9
TC18000568.hg.1	0.6690529	4.512667	4.014972	0.0033257	0.0033257	-1.7044700	—	—
PSR16011592.hg.1	0.6466538	6.009157	4.005829	0.0033346	0.0033346	-1.7105661	—	—
TC04001324.hg.1	0.6248542	5.114606	4.005122	0.0033353	0.0033353	-1.7110432	—	—
TC02003078.hg.1	-0.4735144	3.555687	-4.000984	0.0033306	0.0033306	-1.7119862	—	—
TC06000510.hg.1	-0.4440955	5.786219	-4.000511	0.0033329	0.0033329	-1.7126929	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A
TC13001330.hg.1	-0.7292580	2.590399	-4.030618	0.0034057	0.0034057	-1.7138266	—	—
TC0X000172.hg.1	0.5796677	6.446394	3.999433	0.0033382	0.0033382	-1.7143038	RNU6-49P	RNA, U6 small nuclear 49, pseudogene
TC10002965.hg.1	0.4453274	3.871908	3.998824	0.0033412	0.0033412	-1.7152152	DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9
TC08001723.hg.1	-0.4711672	7.128308	-3.998527	0.0033427	0.0033427	-1.7156597	TSTA3	tissue specific transplantation antigen P35B
TC0X000050.hg.1	0.4931122	9.394130	3.998071	0.0033449	0.0033449	-1.7163409	PRPS2	phosphoribosyl pyrophosphate synthetase 2
TC14001314.hg.1	0.4417389	4.187709	3.996691	0.0033517	0.0033517	-1.7184052	—	—
47420806_st	0.6715134	1.707059	4.029530	0.0034315	0.0034315	-1.7196016	—	—
TC08001226.hg.1	0.5826470	4.943675	3.996070	0.0033614	0.0033614	-1.7207029	—	—
TC04001952.hg.1	-0.5986863	1.559629	-4.013769	0.0034066	0.0034066	-1.7217752	—	—
TC19002566.hg.1	0.6826685	4.527287	4.004383	0.0033862	0.0033862	-1.7219494	LOC284373	uncharacterized LOC284373
TC14001432.hg.1	0.4708999	5.680406	3.993463	0.0033677	0.0033677	-1.7232324	TTC7B	tetratricopeptide repeat domain 7B
TC0X000042.hg.1	0.5174697	9.659572	3.992524	0.0033724	0.0033724	-1.7246376	HCCS	holocytochrome c synthase
TC11002788.hg.1	0.9003976	7.828384	4.032417	0.0034675	0.0034675	-1.7255391	—	—
47419637_st	0.5755238	1.225102	4.012460	0.0034258	0.0034258	-1.7262917	—	—
TC08002618.hg.1	0.4625605	6.233569	3.991408	0.0033780	0.0033780	-1.7263081	C8orf76	chromosome 8 open reading frame 76
TC12002552.hg.1	0.6678807	5.767873	3.997228	0.0033961	0.0033961	-1.7273191	—	—
TC0X001396.hg.1	0.5390124	6.479203	3.987695	0.0033965	0.0033965	-1.7318638	FAM122B	family with sequence similarity 122B
TC14000176.hg.1	0.5643239	4.993986	3.987303	0.0033985	0.0033985	-1.7324511	LOC101927081	uncharacterized LOC101927081
TC01000639.hg.1	0.6138838	5.679940	3.989893	0.0034077	0.0034077	-1.7331136	ZFYVE9	zinc finger, FYVE domain containing 9
TC15000595.hg.1	0.4755718	2.169165	3.986393	0.0034031	0.0034031	-1.7338132	—	—
TC18000719.hg.1	0.4369088	2.154288	3.985940	0.0034053	0.0034053	-1.7344912	—	—
TC6_cox_hap2000236.hg.1	-0.4754318	8.015541	-3.985552	0.0034073	0.0034073	-1.7350710	HLA-C	major histocompatibility complex, class I, C
TC10002437.hg.1	0.4868427	6.915309	3.984224	0.0034140	0.0034140	-1.7370595	ASB13	ankyrin repeat and SOCS box containing 13
PSR01002164.hg.1	0.4422134	5.494373	3.983299	0.0034187	0.0034187	-1.7384441	—	—
TC04002527.hg.1	-0.4651267	2.940578	-3.983167	0.0034193	0.0034193	-1.7386416	—	—
TC01005396.hg.1	-0.5050804	3.868212	-3.983105	0.0034196	0.0034196	-1.7387354	—	—
TC10000445.hg.1	0.5080350	5.501783	3.981461	0.0034280	0.0034280	-1.7411963	CHST3	carbohydrate (chondroitin 6) sulfotransferase 3
TC12001269.hg.1	-0.5135913	7.803033	-3.980629	0.0034322	0.0034322	-1.7424429	PLBD1	phospholipase B domain containing 1
TC19000686.hg.1	0.6959187	7.690906	3.984345	0.0034491	0.0034491	-1.7441137	SNAR-A12	small ILF3/NF90-associated RNA A12
TC19000693.hg.1	0.6959187	7.690906	3.984345	0.0034491	0.0034491	-1.7441137	SNAR-A12	small ILF3/NF90-associated RNA A12
TC02004777.hg.1	-0.5992055	7.920003	-3.977902	0.0034460	0.0034460	-1.7465266	CLK1	CDC-like kinase 1
TC13000744.hg.1	-0.6803689	6.294644	-3.983764	0.0034627	0.0034627	-1.7471340	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase
TC01005621.hg.1	-0.4726526	2.998519	-3.977312	0.0034490	0.0034490	-1.7474113	—	—
TC17002754.hg.1	-0.5723064	4.817455	-3.976904	0.0034511	0.0034511	-1.7480219	HELZ	helicase with zinc finger
TC11002379.hg.1	-0.4481563	2.603769	-3.976780	0.0034518	0.0034518	-1.7482087	—	—
TC06003424.hg.1	-0.4570400	9.467729	-3.976381	0.0034538	0.0034538	-1.7488065	ECI2	enoyl-CoA delta isomerase 2
TC14000205.hg.1	0.5332668	6.828373	3.975982	0.0034558	0.0034558	-1.7494035	ARHGAP5	Rho GTPase activating protein 5
TC0Y000301.hg.1	0.5985206	4.081562	3.978604	0.0034649	0.0034649	-1.7499849	TTTY20	testis-specific transcript, Y-linked 20 (non-protein coding)
TC21000211.hg.1	0.6139490	9.962605	3.977133	0.0034624	0.0034624	-1.7501803	—	—
TC05002634.hg.1	-0.4507534	6.672090	-3.974480	0.0034635	0.0034635	-1.7516540	JADE2	jade family PHD finger 2
TC09002497.hg.1	-0.4077830	2.036170	-3.973775	0.0034671	0.0034671	-1.7527103	—	—
TC14000406.hg.1	0.6318724	7.868813	3.973760	0.0034672	0.0034672	-1.7527331	EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
47419614_st	0.4841734	1.250638	3.976218	0.0034771	0.0034771	-1.7535626	—	—
TC02001148.hg.1	-0.5152301	7.278426	-3.972847	0.0034719	0.0034719	-1.7541014	COQ10B	coenzyme Q10 homolog B (S. cerevisiae)
TC02003174.hg.1	0.4647858	3.871090	3.972807	0.0034721	0.0034721	-1.7541621	LOC728730	uncharacterized LOC728730
TC01003192.hg.1	1.0093971	6.160122	4.093816	0.0037600	0.0037600	-1.7544531	HIST2H4B	histone cluster 2, H4b
TC10000837.hg.1	0.4789830	7.053679	3.971450	0.0034791	0.0034791	-1.7561952	TRUB1	TruB pseudouridine (psi) synthase family member 1
TC05000837.hg.1	-0.5181006	4.961466	-3.970839	0.0034822	0.0034822	-1.7571113	GPX3	glutathione peroxidase 3 (plasma)
TC03000318.hg.1	0.6689759	5.180360	3.978641	0.0035077	0.0035077	-1.7585103	DOCK3	dedicator of cytokinesis 3
TC0X002218.hg.1	0.4488839	4.265293	3.969739	0.0034879	0.0034879	-1.7587608	C1GALT1C1	C1GALT1-specific chaperone 1
TC15001859.hg.1	0.4744433	3.133998	3.969039	0.0034915	0.0034915	-1.7598101	—	—
TC6_mcf_hap5000203.hg.1	-0.5276346	7.457541	-3.967776	0.0034980	0.0034980	-1.7617023	HLA-F	major histocompatibility complex, class I, F
TC02003715.hg.1	-0.5899199	4.866656	-3.968065	0.0035091	0.0035091	-1.7637558	LOC101927027	uncharacterized LOC101927027
TC02001407.hg.1	-0.5268622	3.577079	-3.965411	0.0035103	0.0035103	-1.7652496	—	—
TC21000355.hg.1	0.4372750	5.083423	3.963848	0.0035184	0.0035184	-1.7675939	—	—
TC05000390.hg.1	0.4738542	5.059607	3.963205	0.0035218	0.0035218	-1.7685573	—	—
47423501_st	0.6083314	1.374211	3.990081	0.0035952	0.0035952	-1.7702503	—	—
TC18000741.hg.1	0.8176025	7.802471	3.985103	0.0035852	0.0035852	-1.7706475	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
3615292_st	0.4830146	6.352336	3.961795	0.0035291	0.0035291	-1.7706734	—	—
TC06000189.hg.1	-0.4744003	6.274258	-3.961735	0.0035294	0.0035294	-1.7707623	BTN2A1	butyrophilin, subfamily 2, member A1
TC06000612.hg.1	-0.5981921	6.623909	-3.961589	0.0035302	0.0035302	-1.7709815	TMEM63B	transmembrane protein 63B
TC12002967.hg.1	0.6152317	8.475683	3.961297	0.0035317	0.0035317	-1.7714195	NAP1L1	nucleosome assembly protein 1-like 1
TC20000445.hg.1	0.4674124	5.793773	3.959155	0.0035429	0.0035429	-1.7746332	—	—
TC04000299.hg.1	0.5836465	6.645438	3.957576	0.0035512	0.0035512	-1.7770037	SNORA26	small nucleolar RNA, H/ACA box 26
TC10000575.hg.1	0.5935204	5.265652	3.957477	0.0035667	0.0035667	-1.7800576	TMEM254	transmembrane protein 254
TC09001730.hg.1	0.4525074	6.951782	3.955092	0.0035643	0.0035643	-1.7807309	SDCCAG3	serologically defined colon cancer antigen 3
TC10001099.hg.1	0.6304357	8.093968	3.954263	0.0035687	0.0035687	-1.7819752	—	—
TC6_dbb_hap3000016.hg.1	-0.4978782	6.332198	-3.954024	0.0035700	0.0035700	-1.7823340	HLA-F	major histocompatibility complex, class I, F
TC6_mann_hap4000017.hg.1	-0.4978782	6.332198	-3.954024	0.0035700	0.0035700	-1.7823340	HLA-F	major histocompatibility complex, class I, F
TC6_qbl_hap6000015.hg.1	-0.4978782	6.332198	-3.954024	0.0035700	0.0035700	-1.7823340	HLA-F	major histocompatibility complex, class I, F
PSR01001654.hg.1	0.4139949	11.147321	3.953118	0.0035748	0.0035748	-1.7836950	—	—
TC04000172.hg.1	-0.4193548	2.203774	-3.952392	0.0035786	0.0035786	-1.7847844	RP13-497K6.1	putative novel transcript
TC06004059.hg.1	-0.4765698	8.007808	-3.951596	0.0035828	0.0035828	-1.7859799	HLA-C	major histocompatibility complex, class I, C
TC06002173.hg.1	0.5280282	5.486588	3.949176	0.0035957	0.0035957	-1.7896133	RP3-460G2.2	putative novel transcript
TC08001009.hg.1	-0.4297345	1.559844	-3.948873	0.0035973	0.0035973	-1.7900681	RP11-13N12.1	novel transcript
47419399_st	-0.5473510	1.376656	-3.958958	0.0036224	0.0036224	-1.7900979	—	—
TC03000494.hg.1	-0.3626867	1.763492	-3.947271	0.0036059	0.0036059	-1.7924742	GPR15	G protein-coupled receptor 15
TC05003448.hg.1	-0.4257251	4.705033	-3.946888	0.0036079	0.0036079	-1.7930505	C1QTNF3-AMACR	C1QTNF3-AMACR readthrough (NMD candidate)
TC17000965.hg.1	-0.5295653	5.416573	-3.943882	0.0036240	0.0036240	-1.7975653	FAM101B	family with sequence similarity 101, member B
TC01004332.hg.1	0.5172694	6.854328	3.942864	0.0036295	0.0036295	-1.7990954	PPIE	peptidylprolyl isomerase E (cyclophilin E)
TC05002678.hg.1	0.6179679	3.219490	3.946332	0.0036516	0.0036516	-1.8016394	—	—
TC02004761.hg.1	-0.4394823	2.388752	-3.941151	0.0036388	0.0036388	-1.8016693	ANKRD44	ankyrin repeat domain 44
TC12002798.hg.1	0.6285943	4.052799	3.946155	0.0036526	0.0036526	-1.8019041	—	—
PSR11032411.hg.1	0.4419985	10.048460	3.939908	0.0036455	0.0036455	-1.8035377	—	—
TC19000519.hg.1	0.6174596	3.848327	3.943515	0.0036577	0.0036577	-1.8041256	LOC644554	uncharacterized LOC644554
TC03002151.hg.1	0.5941084	4.923852	3.942251	0.0036561	0.0036561	-1.8044249	LOC101929697	uncharacterized LOC101929697
TC11000903.hg.1	0.4313026	3.445322	3.938774	0.0036516	0.0036516	-1.8052426	FAT3	FAT atypical cadherin 3
TC09002622.hg.1	0.7250721	6.253987	3.949594	0.0036899	0.0036899	-1.8072983	—	—
TC0X000252.hg.1	-0.5803590	7.068467	-3.937372	0.0036592	0.0036592	-1.8073497	PORCN	porcupine homolog (Drosophila)
TC10002637.hg.1	0.5718519	6.894303	3.936740	0.0036627	0.0036627	-1.8083006	PARGP1	poly (ADP-ribose) glycohydrolase pseudogene 1
TC0X000134.hg.1	-0.7130163	2.488893	-3.965706	0.0037405	0.0037405	-1.8091071	—	—
TC22001181.hg.1	-0.4904827	5.317918	-3.936089	0.0036662	0.0036662	-1.8092787	LOC284939	uncharacterized LOC284939
TC0X001804.hg.1	0.5037604	3.934806	3.933983	0.0036777	0.0036777	-1.8124451	—	—
TC15000608.hg.1	0.5047596	3.818895	3.933930	0.0036780	0.0036780	-1.8125246	RNU6-265P	RNA, U6 small nuclear 265, pseudogene
TC12000884.hg.1	-0.4954337	4.416940	-3.933661	0.0036794	0.0036794	-1.8129291	OAS1	2-5-oligoadenylate synthetase 1, 40/46kDa
TC18000116.hg.1	0.7256515	3.716914	3.954283	0.0037321	0.0037321	-1.8129498	AC015933.2	novel transcript, antisense to CDH2
TC0X001501.hg.1	0.5461623	7.349290	3.933601	0.0036798	0.0036798	-1.8130201	CSAG2	CSAG family, member 2
TC19001622.hg.1	0.6827440	6.488263	3.939053	0.0036999	0.0036999	-1.8141961	—	—
TC10002052.hg.1	0.5271747	6.314510	3.930546	0.0036965	0.0036965	-1.8176152	FAM35BP	family with sequence similarity 35, member A pseudogene
TC15001215.hg.1	0.4201353	2.677936	3.930316	0.0036977	0.0036977	-1.8179600	—	—
TC18000718.hg.1	-0.3914986	2.159152	-3.929936	0.0036998	0.0036998	-1.8185326	—	—
TC15000060.hg.1	0.5252047	7.407166	3.929449	0.0037025	0.0037025	-1.8192652	SNORD116-14	small nucleolar RNA, C/D box 116-14
TC19002120.hg.1	0.5428782	5.279053	3.928264	0.0037090	0.0037090	-1.8210477	LOC101927667	uncharacterized LOC101927667
TC03002941.hg.1	-0.5142910	4.476906	-3.927537	0.0037130	0.0037130	-1.8221418	PTPRG-AS1	PTPRG antisense RNA 1
TC08000250.hg.1	-0.4811073	6.299757	-3.926651	0.0037179	0.0037179	-1.8234750	NRG1	neuregulin 1
TC17000776.hg.1	0.5641763	6.673457	3.925946	0.0037218	0.0037218	-1.8245356	SNORA76C	small nucleolar RNA, H/ACA box 76C
TC11003320.hg.1	-0.3999475	1.923140	-3.925938	0.0037219	0.0037219	-1.8245484	CASP12	caspase 12 (gene/pseudogene)
TC15001473.hg.1	0.6614789	6.039540	3.931778	0.0037386	0.0037386	-1.8248478	CNOT6LP1	CCR4-NOT transcription complex, subunit 6-like pseudogene 1
TC09000340.hg.1	0.4774845	2.609438	3.922963	0.0037383	0.0037383	-1.8290253	RNY4P1	RNA, Ro-associated Y4 pseudogene 1
TC0X000088.hg.1	-0.4511501	5.149322	-3.922867	0.0037389	0.0037389	-1.8291697	CDKL5	cyclin-dependent kinase-like 5
TC0Y000344.hg.1	-0.4783856	2.705352	-3.922775	0.0037394	0.0037394	-1.8293078	—	—
TC08001824.hg.1	-0.3807677	2.347414	-3.922489	0.0037410	0.0037410	-1.8297392	—	—
TC18000201.hg.1	0.4743523	2.898056	3.921057	0.0037490	0.0037490	-1.8318942	RSL24D1P11	ribosomal L24 domain containing 1 pseudogene 11
TC03002995.hg.1	-0.4463741	6.479995	-3.918461	0.0037634	0.0037634	-1.8358031	—	—
47419770_st	-0.5900101	1.757622	-3.932493	0.0038024	0.0038024	-1.8361773	—	—
TC01003305.hg.1	0.5062002	6.291722	3.917351	0.0037697	0.0037697	-1.8374746	THBS3	thrombospondin 3
TC19002465.hg.1	0.5770418	5.363414	3.917900	0.0037737	0.0037737	-1.8379526	ZNF529	zinc finger protein 529
TC6_ssto_hap7000169.hg.1	-0.4952017	6.728287	-3.917015	0.0037715	0.0037715	-1.8379798	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC01004933.hg.1	-0.5319498	4.881142	-3.915494	0.0037801	0.0037801	-1.8402707	LHX9	LIM homeobox 9
TC01005808.hg.1	0.5023096	4.613042	3.915458	0.0037803	0.0037803	-1.8403253	—	—
TC10002123.hg.1	0.4797790	7.982295	3.914352	0.0037865	0.0037865	-1.8419919	ANAPC16	anaphase promoting complex subunit 16
TC11001174.hg.1	-0.5857414	6.005391	-3.914204	0.0037873	0.0037873	-1.8422146	ST3GAL4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TC02004554.hg.1	-0.4061320	1.985315	-3.913862	0.0037893	0.0037893	-1.8427300	—	—
TC10001192.hg.1	0.4780925	4.681850	3.912409	0.0037975	0.0037975	-1.8449185	LOC441666	zinc finger protein 91 pseudogene
TC0X000889.hg.1	0.4192625	2.494389	3.909972	0.0038113	0.0038113	-1.8485909	—	—
TC06001077.hg.1	-0.4191544	5.115681	-3.909871	0.0038118	0.0038118	-1.8487430	UST	uronyl-2-sulfotransferase
TC02002430.hg.1	-0.4251422	4.829386	-3.908410	0.0038201	0.0038201	-1.8509440	CACNB4	calcium channel, voltage-dependent, beta 4 subunit
TC17001771.hg.1	0.3935185	1.544381	3.908115	0.0038218	0.0038218	-1.8513889	—	—
PSR11013603.hg.1	0.5666320	8.339064	3.906929	0.0038285	0.0038285	-1.8531759	—	—
TC03003097.hg.1	0.5224179	4.778254	3.906658	0.0038301	0.0038301	-1.8535840	BFSP2-AS1	BFSP2 antisense RNA 1
TC13000523.hg.1	-0.4967523	7.444127	-3.906334	0.0038319	0.0038319	-1.8540731	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
PSR10021736.hg.1	0.6296040	7.598997	3.904373	0.0038504	0.0038504	-1.8583230	—	—
TC03001618.hg.1	0.4377253	9.946122	3.902336	0.0038548	0.0038548	-1.8601004	RPL24	ribosomal protein L24
TC15002113.hg.1	-0.5199668	5.468954	-3.901783	0.0038580	0.0038580	-1.8609351	—	—
TC0X001082.hg.1	0.4973336	6.389956	3.901657	0.0038587	0.0038587	-1.8611244	XAGE-4	XAGE-4 protein
TC03001611.hg.1	0.4857788	8.209097	3.901295	0.0038608	0.0038608	-1.8616703	TOMM70A	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TC06003017.hg.1	-0.4363462	1.496864	-3.900467	0.0038655	0.0038655	-1.8629184	PLN	phospholamban
TC0X000593.hg.1	0.7600826	6.627786	3.919114	0.0039221	0.0039221	-1.8639214	ZBTB33	zinc finger and BTB domain containing 33
TC11003278.hg.1	0.4570466	6.951087	3.899751	0.0038697	0.0038697	-1.8639994	CREBZF	CREB/ATF bZIP transcription factor
TC14000466.hg.1	0.4921387	8.841767	3.899635	0.0038703	0.0038703	-1.8641735	EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
TC06000725.hg.1	0.6101576	3.932130	3.902159	0.0038888	0.0038888	-1.8662205	—	—
TC01004608.hg.1	-0.4928841	9.817452	-3.897965	0.0038800	0.0038800	-1.8666929	GSTM4	glutathione S-transferase mu 4
TC09000073.hg.1	0.4922764	4.605470	3.897771	0.0038811	0.0038811	-1.8669857	LOC389705	chromosome 4 open reading frame 27 pseudogene
TC19000964.hg.1	0.4343201	10.198227	3.897292	0.0038839	0.0038839	-1.8677078	RPS5	ribosomal protein S5
TC20000389.hg.1	0.5511962	9.111103	3.897034	0.0038854	0.0038854	-1.8680969	SNORD12	small nucleolar RNA, C/D box 12
TC0X000886.hg.1	0.4580136	8.520159	3.894715	0.0038988	0.0038988	-1.8715960	RBBP7	retinoblastoma binding protein 7
TC22000062.hg.1	-0.4387824	3.943634	-3.894278	0.0039013	0.0039013	-1.8722544	—	—
TC22000091.hg.1	-0.4387824	3.943634	-3.894278	0.0039013	0.0039013	-1.8722544	—	—
TC22000540.hg.1	-0.4387824	3.943634	-3.894278	0.0039013	0.0039013	-1.8722544	—	—
TC0Y000271.hg.1	0.4232922	5.165398	3.893522	0.0039057	0.0039057	-1.8733957	RBMY2FP	RNA binding motif protein, Y-linked, family 2, member F pseudogene
TC06004067.hg.1	-0.4338986	5.818462	-3.893138	0.0039080	0.0039080	-1.8739751	HLA-J	major histocompatibility complex, class I, J (pseudogene)
TC13000919.hg.1	-0.5630158	7.096256	-3.892593	0.0039112	0.0039112	-1.8747984	—	—
TC01001856.hg.1	-0.5144859	8.178896	-3.892317	0.0039128	0.0039128	-1.8752148	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)
TC05000279.hg.1	-0.4693241	7.104449	-3.890151	0.0039254	0.0039254	-1.8784839	NLN	neurolysin (metallopeptidase M3 family)
TC06000697.hg.1	-0.5182809	7.758388	-3.890093	0.0039258	0.0039258	-1.8785706	PTP4A1	protein tyrosine phosphatase type IVA, member 1
2960238_st	0.4826879	10.264247	3.889274	0.0039305	0.0039305	-1.8798068	—	—
TC11001762.hg.1	0.4832212	5.791940	3.888992	0.0039322	0.0039322	-1.8802331	LOC441601	septin 7 pseudogene
TC19002008.hg.1	-0.5051464	3.630179	-3.888350	0.0039360	0.0039360	-1.8812016	—	—
TC07000645.hg.1	-0.9966874	4.803094	-4.027414	0.0043277	0.0043277	-1.8814552	MIR4653	microRNA 4653
TC17002397.hg.1	0.4940013	3.843996	3.887582	0.0039405	0.0039405	-1.8823617	—	—
TC6_mann_hap4000167.hg.1	-0.4908322	6.723372	-3.883997	0.0039616	0.0039616	-1.8877753	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC6_qbl_hap6000187.hg.1	-0.4908322	6.723372	-3.883997	0.0039616	0.0039616	-1.8877753	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC10002232.hg.1	0.4626951	4.395908	3.882619	0.0039697	0.0039697	-1.8898561	C10orf12	chromosome 10 open reading frame 12
TC01002299.hg.1	0.5945708	6.311196	3.883102	0.0039743	0.0039743	-1.8904027	RNU6-1099P	RNA, U6 small nuclear 1099, pseudogene
TC20000998.hg.1	-0.3908727	1.622841	-3.881725	0.0039750	0.0039750	-1.8912070	RNU7-141P	RNA, U7 small nuclear 141 pseudogene
TC19002440.hg.1	0.4730561	4.633690	3.881711	0.0039751	0.0039751	-1.8912272	LOC400684	uncharacterized LOC400684
TC14001708.hg.1	0.4521256	9.207824	3.880225	0.0039839	0.0039839	-1.8934730	PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
TC03001755.hg.1	-0.6637622	8.083271	-3.882128	0.0039984	0.0039984	-1.8950205	GATA2	GATA binding protein 2
TC11003336.hg.1	0.4419034	5.895774	3.878768	0.0039926	0.0039926	-1.8956737	—	—
TC05000736.hg.1	-0.5681127	3.781531	-3.879563	0.0039953	0.0039953	-1.8957467	VTRNA1-3	vault RNA 1-3
TC20000387.hg.1	0.7573909	7.786196	3.891377	0.0040304	0.0040304	-1.8959913	SNORD12C	small nucleolar RNA, C/D box 12C
TC19002709.hg.1	-0.4383046	5.336531	-3.877572	0.0039997	0.0039997	-1.8974810	PSG10P	pregnancy specific beta-1-glycoprotein 10, pseudogene
TC0X002099.hg.1	-0.4733092	6.218489	-3.875710	0.0040109	0.0040109	-1.9002946	—	—
TC02000891.hg.1	0.4366958	2.773835	3.875619	0.0040114	0.0040114	-1.9004322	HNMT	histamine N-methyltransferase
TC10002160.hg.1	0.5773459	6.370434	3.874127	0.0040204	0.0040204	-1.9026875	ZMIZ1	zinc finger, MIZ-type containing 1
TC16000058.hg.1	-0.5466804	6.423370	-3.873501	0.0040241	0.0040241	-1.9036337	SLC9A3R2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
TC05000368.hg.1	0.6938523	6.533391	3.881605	0.0040478	0.0040478	-1.9037002	IQGAP2	IQ motif containing GTPase activating protein 2
TC13000234.hg.1	-0.5417403	3.523813	-3.872544	0.0040299	0.0040299	-1.9050793	PCDH17	protocadherin 17
TC05001154.hg.1	0.4867786	2.692320	3.872432	0.0040305	0.0040305	-1.9052497	CTD-2201E9.2	novel transcript
TC02000049.hg.1	-0.4109484	1.687171	-3.871897	0.0040338	0.0040338	-1.9060575	RP11-400L8.2	novel transcript
TC02004066.hg.1	-0.4493291	3.125987	-3.871862	0.0040340	0.0040340	-1.9061106	AC010145.4	novel transcript
TC06001574.hg.1	-0.4895809	6.723144	-3.870248	0.0040437	0.0040437	-1.9085509	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC6_cox_hap2000199.hg.1	-0.4895809	6.723144	-3.870248	0.0040437	0.0040437	-1.9085509	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC10002327.hg.1	0.6340425	5.817825	3.872685	0.0040728	0.0040728	-1.9122661	—	—
TC19000577.hg.1	-0.4649802	8.548357	-3.867543	0.0040601	0.0040601	-1.9126412	HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1
TC15000202.hg.1	0.5823453	10.006453	3.867406	0.0040631	0.0040631	-1.9132140	RNU6-18P	RNA, U6 small nuclear 18, pseudogene
TC15001135.hg.1	0.5823453	10.006453	3.867406	0.0040631	0.0040631	-1.9132140	RNU6-17P	RNA, U6 small nuclear 17, pseudogene
TC09002891.hg.1	0.4376551	5.210460	3.867047	0.0040631	0.0040631	-1.9133921	EXOSC3	exosome component 3
TC05001384.hg.1	-0.3853259	1.768688	-3.866554	0.0040661	0.0040661	-1.9141365	LOC101928569	uncharacterized LOC101928569
TC07003109.hg.1	-0.3577448	1.346097	-3.865477	0.0040726	0.0040726	-1.9157654	—	—
47423848_st	-0.6629643	2.169504	-3.891142	0.0041491	0.0041491	-1.9160037	—	—
JUC04005583.hg.1	0.4877675	8.005614	3.865272	0.0040739	0.0040739	-1.9160766	—	—
TC6_apd_hap1000105.hg.1	-0.4882816	6.721073	-3.864774	0.0040769	0.0040769	-1.9168300	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC6_dbb_hap3000185.hg.1	-0.4882816	6.721073	-3.864774	0.0040769	0.0040769	-1.9168300	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC6_mcf_hap5000174.hg.1	-0.4882816	6.721073	-3.864774	0.0040769	0.0040769	-1.9168300	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TC06003448.hg.1	-0.6433929	8.276817	-3.866211	0.0040932	0.0040932	-1.9188552	BLOC1S5-TXNDC5	BLOC1S5-TXNDC5 readthrough (NMD candidate)
TC02001198.hg.1	-0.4885995	6.802539	-3.862958	0.0040880	0.0040880	-1.9195768	ABI2	abl-interactor 2
TC01001497.hg.1	0.4237693	5.600395	3.862761	0.0040892	0.0040892	-1.9198748	—	—
TC14000312.hg.1	0.7020199	2.413999	3.892069	0.0041762	0.0041762	-1.9200025	—	—
TC0X002061.hg.1	-0.4540825	2.978896	-3.862103	0.0040932	0.0040932	-1.9208697	—	—
TC19001371.hg.1	0.5248358	2.193270	3.864700	0.0041024	0.0041024	-1.9211355	LOC100505851	uncharacterized LOC100505851
TC04000301.hg.1	0.5600427	8.664765	3.861728	0.0040955	0.0040955	-1.9214375	—	—
TC03000162.hg.1	0.5014299	6.866252	3.861714	0.0040956	0.0040956	-1.9214583	CNOT10	CCR4-NOT transcription complex, subunit 10
TC08002008.hg.1	-0.7275370	10.304282	-3.879932	0.0041578	0.0041578	-1.9228717	RIPK2	receptor-interacting serine-threonine kinase 2
TC13000413.hg.1	-0.6143625	6.313271	-3.863508	0.0041097	0.0041097	-1.9229367	—	—
TC0Y000263.hg.1	0.6137385	4.942926	3.865505	0.0041165	0.0041165	-1.9230883	NLGN4Y	neuroligin 4, Y-linked
TC15002702.hg.1	0.4729126	4.901974	3.860312	0.0041042	0.0041042	-1.9235807	—	—
TC07003094.hg.1	-0.3354879	1.322275	-3.859392	0.0041098	0.0041098	-1.9249718	—	—
JUC0X002528.hg.1	0.5343882	7.319367	3.857336	0.0041225	0.0041225	-1.9280848	—	—
TC14000855.hg.1	0.4723149	4.594388	3.856517	0.0041275	0.0041275	-1.9293238	—	—
TC15000210.hg.1	0.6206756	7.046235	3.857684	0.0041337	0.0041337	-1.9297679	—	—
TC14000880.hg.1	0.6613928	8.369928	3.857933	0.0041477	0.0041477	-1.9319582	—	—
TC04001245.hg.1	-0.4574582	3.139599	-3.854718	0.0041386	0.0041386	-1.9320468	EPHA5	EPH receptor A5
TC04001940.hg.1	-0.6829124	2.978195	-3.872199	0.0041946	0.0041946	-1.9326562	—	—
TC01002066.hg.1	-0.5573634	7.839182	-3.853613	0.0041455	0.0041455	-1.9337192	LOC100133331	uncharacterized LOC100133331
TC01005690.hg.1	0.6014514	8.967515	3.853571	0.0041457	0.0041457	-1.9337836	GSTM3	glutathione S-transferase mu 3 (brain)
TC17000012.hg.1	0.6581876	7.515429	3.855964	0.0041599	0.0041599	-1.9349317	PITPNA-AS1	PITPNA antisense RNA 1
PSR02004940.hg.1	0.4791526	10.244208	3.851631	0.0041578	0.0041578	-1.9367217	—	—
TC06000895.hg.1	-0.5251640	5.616807	-3.850866	0.0041625	0.0041625	-1.9378792	FAM229B	family with sequence similarity 229, member B
TC07001020.hg.1	-0.4588720	3.355356	-3.850635	0.0041640	0.0041640	-1.9382291	PRKAG2-AS1	PRKAG2 antisense RNA 1
TC21000056.hg.1	-0.4868817	2.361543	-3.850501	0.0041648	0.0041648	-1.9384329	AP000431.2	putative novel transcript
TC06002615.hg.1	0.7373536	4.838790	3.876853	0.0042548	0.0042548	-1.9401178	SOX4	SRY (sex determining region Y)-box 4
TC15000651.hg.1	0.6414715	8.150956	3.850578	0.0041884	0.0041884	-1.9422530	RNA5SP399	RNA, 5S ribosomal pseudogene 399
TC21000337.hg.1	0.4071672	2.348226	3.847172	0.0041856	0.0041856	-1.9434751	LINC00515	long intergenic non-protein coding RNA 515
TC09001748.hg.1	0.6228293	5.858823	3.851176	0.0042014	0.0042014	-1.9440601	CLIC3	chloride intracellular channel 3
TC08001000.hg.1	0.4651232	4.878457	3.846340	0.0041908	0.0041908	-1.9447356	DLC1	DLC1 Rho GTPase activating protein
TC08002355.hg.1	0.4164321	2.799989	3.846017	0.0041929	0.0041929	-1.9452243	—	—
TC02002041.hg.1	0.7029687	2.803164	3.871409	0.0042707	0.0042707	-1.9453188	—	—
TC14000032.hg.1	0.4243779	4.548127	3.845750	0.0041945	0.0041945	-1.9456296	—	—
TC01004107.hg.1	-0.5241239	1.418632	-3.852226	0.0042283	0.0042283	-1.9479001	RP5-857K21.3	putative novel transcript
JUC04005579.hg.1	0.7546207	8.761306	3.859001	0.0042496	0.0042496	-1.9480080	—	—
TC18000195.hg.1	-0.4419994	6.611053	-3.843842	0.0042065	0.0042065	-1.9485201	ONECUT2	one cut homeobox 2
TC6_ssto_hap7000216.hg.1	-0.4183329	5.605119	-3.841147	0.0042235	0.0042235	-1.9526045	HLA-J	major histocompatibility complex, class I, J (pseudogene)
TC10000912.hg.1	0.5579882	6.802006	3.840759	0.0042260	0.0042260	-1.9531926	EDRF1	erythroid differentiation regulatory factor 1
TC09001687.hg.1	0.4269928	5.945866	3.840275	0.0042290	0.0042290	-1.9539261	SURF1	surfeit 1
TC20000934.hg.1	0.4372567	4.411716	3.838567	0.0042399	0.0042399	-1.9565151	LINC01271	long intergenic non-protein coding RNA 1271
TC07000018.hg.1	0.4495749	5.396551	3.838208	0.0042422	0.0042422	-1.9570584	GPER1	G protein-coupled estrogen receptor 1
TC17001686.hg.1	0.4550700	4.367137	3.837857	0.0042444	0.0042444	-1.9575905	LRRC59	leucine rich repeat containing 59
TC02002688.hg.1	-0.7646659	7.199715	-3.854945	0.0043028	0.0043028	-1.9584818	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
TC12003138.hg.1	-0.3596626	1.643196	-3.836349	0.0042540	0.0042540	-1.9598781	—	—
TC17001966.hg.1	-0.4722387	6.849028	-3.836295	0.0042543	0.0042543	-1.9599588	PYCR1	pyrroline-5-carboxylate reductase 1
TC13000877.hg.1	0.4912389	4.846143	3.836165	0.0042552	0.0042552	-1.9601562	LINC00346	long intergenic non-protein coding RNA 346
TC06003598.hg.1	0.4794608	5.081492	3.835863	0.0042571	0.0042571	-1.9606143	LOC100507547	uncharacterized LOC100507547
TC04000496.hg.1	0.3555793	1.705996	3.835259	0.0042609	0.0042609	-1.9615302	RP11-354O24.1	novel gene
TC02002752.hg.1	-0.4738432	3.468063	-3.835207	0.0042613	0.0042613	-1.9616088	AC093382.1	putative novel transcript
TC16001591.hg.1	-0.3792670	1.643738	-3.833989	0.0042690	0.0042690	-1.9634563	—	—
TC02001101.hg.1	-0.6489537	6.595083	-3.837578	0.0042915	0.0042915	-1.9652446	FAM171B	family with sequence similarity 171, member B
TC0X000782.hg.1	0.4628721	6.179797	3.832108	0.0042811	0.0042811	-1.9663089	FUNDC2	FUN14 domain containing 2
TC22001249.hg.1	0.4280897	5.571525	3.832093	0.0042812	0.0042812	-1.9663312	—	—
TC11000951.hg.1	0.4084079	2.701057	3.831942	0.0042822	0.0042822	-1.9665607	C11orf70	chromosome 11 open reading frame 70
TC04002851.hg.1	0.4795687	7.226695	3.831740	0.0042835	0.0042835	-1.9668672	AGA	aspartylglucosaminidase
TC12003251.hg.1	0.4845864	7.454555	3.831559	0.0042846	0.0042846	-1.9671419	RAB3IP	RAB3A interacting protein
TC01004086.hg.1	-0.4531103	2.580176	-3.830035	0.0042944	0.0042944	-1.9694535	OR2T34	olfactory receptor, family 2, subfamily T, member 34
TC18000218.hg.1	0.4977564	9.722826	3.829810	0.0042959	0.0042959	-1.9697942	RNU6-116P	RNA, U6 small nuclear 116, pseudogene
TC05001066.hg.1	0.5493505	4.444265	3.829768	0.0042961	0.0042961	-1.9698576	LINC00847	long intergenic non-protein coding RNA 847
TC02001178.hg.1	-0.5356205	8.333941	-3.829639	0.0042970	0.0042970	-1.9700544	STRADB	STE20-related kinase adaptor beta
TC20001577.hg.1	-0.3672554	1.885199	-3.828605	0.0043036	0.0043036	-1.9716223	—	—
TC15000061.hg.1	0.4710472	9.449388	3.828398	0.0043050	0.0043050	-1.9719371	SNORD116-15	small nucleolar RNA, C/D box 116-15
TC01004298.hg.1	0.4751874	7.644519	3.827571	0.0043103	0.0043103	-1.9731918	TXLNA	taxilin alpha
PSR17013100.hg.1	0.4712941	6.835428	3.826488	0.0043173	0.0043173	-1.9748351	—	—
TC0X001541.hg.1	0.4429118	6.014801	3.825903	0.0043211	0.0043211	-1.9757218	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
TC18000021.hg.1	0.8094009	4.870875	3.876316	0.0044833	0.0044833	-1.9760597	DLGAP1-AS2	DLGAP1 antisense RNA 2
TC05001660.hg.1	-0.4457337	6.186731	-3.824610	0.0043295	0.0043295	-1.9776848	FBXL17	F-box and leucine-rich repeat protein 17
TC19001987.hg.1	0.6945008	5.337462	3.839819	0.0043813	0.0043813	-1.9782328	ZNF788	zinc finger family member 788
TC01000538.hg.1	0.4249525	3.457863	3.823162	0.0043389	0.0043389	-1.9798821	RNU6-880P	RNA, U6 small nuclear 880, pseudogene
47419066_st	0.3410601	1.146254	3.822460	0.0043435	0.0043435	-1.9809479	—	—
TC17000637.hg.1	0.5025889	5.863181	3.821513	0.0043496	0.0043496	-1.9823850	RNU6-826P	RNA, U6 small nuclear 826, pseudogene
TC07002788.hg.1	0.4872781	4.009000	3.821333	0.0043508	0.0043508	-1.9826591	MGC4859	uncharacterized LOC79150
TC07001821.hg.1	-0.5027557	5.383007	-3.820138	0.0043586	0.0043586	-1.9844729	NDUFA5	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
TC03002845.hg.1	-0.4582966	2.956319	-3.819528	0.0043626	0.0043626	-1.9853986	—	—
TC0X002206.hg.1	0.4649480	5.618021	3.818735	0.0043678	0.0043678	-1.9866031	—	—
TC06003668.hg.1	-0.5552302	1.610936	-3.827219	0.0044112	0.0044112	-1.9891013	RP11-268F1.3	putative novel transcript
TC12000839.hg.1	0.5084479	4.051687	3.816774	0.0043807	0.0043807	-1.9895812	—	—
TC01000548.hg.1	-0.5219197	7.151476	-3.816578	0.0043819	0.0043819	-1.9898788	PTPRF	protein tyrosine phosphatase, receptor type, F
TC04000600.hg.1	0.4571571	10.112030	3.816481	0.0043826	0.0043826	-1.9900262	SNORA24	small nucleolar RNA, H/ACA box 24
TC14001292.hg.1	0.6005969	2.750999	3.821979	0.0044025	0.0044025	-1.9903690	—	—
TC16001920.hg.1	0.6094863	7.082943	3.815935	0.0043941	0.0043941	-1.9920768	—	—
TC0Y000352.hg.1	0.7642999	6.137521	3.841760	0.0044813	0.0044813	-1.9926145	XGY2	Xg pseudogene, Y-linked 2
TC10001249.hg.1	0.5484999	4.272181	3.813785	0.0044004	0.0044004	-1.9941210	RP11-463P17.1	novel transcript
TC19000400.hg.1	0.6627234	7.131799	3.818087	0.0044182	0.0044182	-1.9947251	ZNF492	zinc finger protein 492
TC21000183.hg.1	-0.4482728	2.418885	-3.812223	0.0044107	0.0044107	-1.9964939	—	—
TC07001994.hg.1	0.6359993	10.020326	3.816809	0.0044323	0.0044323	-1.9975196	RNY1	RNA, Ro-associated Y1
TC15001568.hg.1	0.4870415	7.741336	3.810789	0.0044202	0.0044202	-1.9986725	RNU6-19P	RNA, U6 small nuclear 19, pseudogene
TC11001164.hg.1	0.4219297	4.411246	3.810425	0.0044226	0.0044226	-1.9992249	HYLS1	hydrolethalus syndrome 1
TC12002688.hg.1	-0.4637207	4.647933	-3.808705	0.0044340	0.0044340	-2.0018390	—	—
TC09001417.hg.1	0.4621339	7.486356	3.807301	0.0044434	0.0044434	-2.0039720	TEX10	testis expressed 10
TC02002660.hg.1	-0.4407822	5.750785	-3.807172	0.0044443	0.0044443	-2.0041681	KCTD18	potassium channel tetramerization domain containing 18
TC0X001612.hg.1	-0.4049616	3.323984	-3.806326	0.0044499	0.0044499	-2.0054547	—	—
TC12000495.hg.1	-0.4043393	5.325142	-3.805576	0.0044549	0.0044549	-2.0065940	DGKA	diacylglycerol kinase, alpha 80kDa
TC14002131.hg.1	0.4471468	6.835949	3.805123	0.0044580	0.0044580	-2.0072831	—	—
TC05000953.hg.1	0.4273702	3.345539	3.805065	0.0044583	0.0044583	-2.0073712	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1
TC08001110.hg.1	-0.4288314	9.597064	-3.804996	0.0044588	0.0044588	-2.0074754	GSR	glutathione reductase
PSR03029264.hg.1	0.5505898	10.839785	3.804508	0.0044621	0.0044621	-2.0082183	—	—
TC15001713.hg.1	0.4262553	5.641779	3.803953	0.0044658	0.0044658	-2.0090611	CTSH	cathepsin H
TC17000947.hg.1	-0.4991745	6.084129	-3.803873	0.0044663	0.0044663	-2.0091826	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3
TC20000353.hg.1	-0.3608539	1.761121	-3.803735	0.0044673	0.0044673	-2.0093926	SPINT4	serine peptidase inhibitor, Kunitz type 4
TC05002949.hg.1	-0.4572785	7.733800	-3.802746	0.0044739	0.0044739	-2.0108962	RAD1	RAD1 homolog (S. pombe)
TC18000894.hg.1	0.5753001	4.625468	3.802370	0.0045031	0.0045031	-2.0154927	—	—
TC02000245.hg.1	0.5079029	5.064196	3.799211	0.0044977	0.0044977	-2.0162715	GALM	galactose mutarotase (aldose 1-epimerase)
TC05002891.hg.1	-0.6153073	4.440449	-3.804373	0.0045184	0.0045184	-2.0167874	—	—
TC10000624.hg.1	0.4973937	1.780982	3.801164	0.0045113	0.0045113	-2.0173242	RP11-380G5.2	putative novel transcript
TC19001468.hg.1	0.8203846	6.869606	3.828256	0.0046082	0.0046082	-2.0182308	ZFP82	ZFP82 zinc finger protein
TC01001774.hg.1	-0.3755766	1.354130	-3.797789	0.0045073	0.0045073	-2.0184347	RP11-384C4.2	putative novel transcript
TC04002805.hg.1	-0.4423504	1.560577	-3.795599	0.0045222	0.0045222	-2.0217649	—	—
TC10001330.hg.1	0.5909357	2.714167	3.800917	0.0045418	0.0045418	-2.0220225	—	—
TC0X001298.hg.1	0.5272147	3.991974	3.795394	0.0045236	0.0045236	-2.0220777	RNU6-154P	RNA, U6 small nuclear 154, pseudogene
TC6_mann_hap4000020.hg.1	-0.4683345	7.535200	-3.794926	0.0045268	0.0045268	-2.0227898	HLA-H	major histocompatibility complex, class I, H (pseudogene)
TC01005855.hg.1	0.4531347	9.876991	3.794167	0.0045320	0.0045320	-2.0239445	—	—
TC10000870.hg.1	0.4636904	6.974951	3.793158	0.0045388	0.0045388	-2.0254795	SEC23IP	SEC23 interacting protein
TC05002866.hg.1	0.4178355	2.408213	3.792674	0.0045421	0.0045421	-2.0262159	—	—
TC03001795.hg.1	0.4761330	3.865536	3.792576	0.0045428	0.0045428	-2.0263654	BFSP2-AS1	BFSP2 antisense RNA 1
TC10000238.hg.1	0.4093066	5.027508	3.792267	0.0045449	0.0045449	-2.0268351	CREM	cAMP responsive element modulator
TC06003085.hg.1	-0.5246475	2.100418	-3.794612	0.0045597	0.0045597	-2.0278469	—	—
TC6_mcf_hap5000207.hg.1	-0.4839232	7.350890	-3.791571	0.0045497	0.0045497	-2.0278936	HLA-H	major histocompatibility complex, class I, H (pseudogene)
TC17001297.hg.1	-0.4674769	6.570499	-3.790463	0.0045573	0.0045573	-2.0295797	SLC46A1	solute carrier family 46 (folate transporter), member 1
TC0X000133.hg.1	-0.7283764	4.370537	-3.816910	0.0046478	0.0046478	-2.0296482	IL1RAPL1	interleukin 1 receptor accessory protein-like 1
TC0X002012.hg.1	0.5025579	4.434914	3.790344	0.0045581	0.0045581	-2.0297619	—	—
2909174_st	-0.5393825	9.928591	-3.790042	0.0045602	0.0045602	-2.0302210	—	—
TC15001907.hg.1	0.4805945	2.345389	3.789574	0.0045634	0.0045634	-2.0309337	—	—
47420247_st	0.6890782	1.240058	3.867452	0.0048298	0.0048298	-2.0309380	—	—
TC06000921.hg.1	-0.3802400	2.177732	-3.789005	0.0045673	0.0045673	-2.0317987	FAM26E	family with sequence similarity 26, member E
TC10000361.hg.1	0.5027253	7.467770	3.788911	0.0045679	0.0045679	-2.0319426	TFAM	transcription factor A, mitochondrial
TC17000149.hg.1	0.4630341	2.809385	3.788874	0.0045682	0.0045682	-2.0319986	MYHAS	myosin heavy chain gene cluster antisense RNA
TC06001245.hg.1	-0.4572928	5.408654	-3.788521	0.0045706	0.0045706	-2.0325364	NRN1	neuritin 1
TC11003387.hg.1	-0.4074501	2.542450	-3.788333	0.0045719	0.0045719	-2.0328227	—	—
TC07001208.hg.1	-0.5856311	4.748965	-3.790774	0.0045860	0.0045860	-2.0336750	C7orf31	chromosome 7 open reading frame 31
TC07001658.hg.1	-0.4709012	7.354926	-3.787344	0.0045787	0.0045787	-2.0343271	TAF6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TC14000429.hg.1	0.4948998	6.138888	3.786400	0.0045852	0.0045852	-2.0357650	PCNX	pecanex homolog (Drosophila)
TC09002562.hg.1	0.5655509	2.855282	3.787466	0.0046088	0.0046088	-2.0387007	—	—
TC17000448.hg.1	0.4680861	7.533087	3.783853	0.0046028	0.0046028	-2.0396422	DUSP14	dual specificity phosphatase 14
TC07000777.hg.1	-0.5634580	7.587052	-3.783766	0.0046034	0.0046034	-2.0397744	LINC01000	long intergenic non-protein coding RNA 1000
TC08000159.hg.1	-0.4083467	2.619863	-3.783758	0.0046035	0.0046035	-2.0397873	LOC101929172	uncharacterized LOC101929172
TC02000102.hg.1	0.5936493	3.455145	3.787586	0.0046204	0.0046204	-2.0403334	—	—
TC16000062.hg.1	0.5152363	7.125276	3.782733	0.0046106	0.0046106	-2.0413476	RAB26	RAB26, member RAS oncogene family
TC16001163.hg.1	0.6987594	5.975392	3.796776	0.0046603	0.0046603	-2.0415127	RNU6-21P	RNA, U6 small nuclear 21, pseudogene
TC15001358.hg.1	0.5328384	7.716701	3.781953	0.0046160	0.0046160	-2.0425358	SPPL2A	signal peptide peptidase like 2A
TC0X001203.hg.1	0.5295895	4.576008	3.780901	0.0046233	0.0046233	-2.0441371	—	—
TC15001272.hg.1	0.4560230	8.714253	3.780099	0.0046289	0.0046289	-2.0453595	RPS3AP47	ribosomal protein S3a pseudogene 47
TC0X001326.hg.1	0.5224513	9.354813	3.779856	0.0046306	0.0046306	-2.0457293	CUL4B	cullin 4B
TC01000862.hg.1	0.3551736	1.503387	3.779749	0.0046313	0.0046313	-2.0458917	—	—
TC02001690.hg.1	0.6287305	3.220968	3.787227	0.0046586	0.0046586	-2.0460746	—	—
TC10002827.hg.1	0.4763360	3.947400	3.779445	0.0046334	0.0046334	-2.0463545	—	—
TC14002199.hg.1	0.6168740	5.954047	3.783292	0.0046502	0.0046502	-2.0468508	ACOT1	acyl-CoA thioesterase 1
TC17000585.hg.1	0.4292895	2.997198	3.778612	0.0046393	0.0046393	-2.0476235	AC091132.1	novel transcript, antisense to PLEKHM1
TC07002824.hg.1	-0.6674775	3.536820	-3.790691	0.0046919	0.0046919	-2.0491404	AC002480.2	novel transcript
TC09001344.hg.1	-0.5066470	4.841444	-3.777426	0.0046476	0.0046476	-2.0494309	RP11-274J16.5	putative novel transcript
TC19001810.hg.1	0.4452949	7.713848	3.777157	0.0046494	0.0046494	-2.0498402	ZNF702P	zinc finger protein 702, pseudogene
TC14002301.hg.1	0.4990002	5.995801	3.775842	0.0046587	0.0046587	-2.0518442	PTGR2	prostaglandin reductase 2
TC17000073.hg.1	0.4793876	6.242223	3.775058	0.0046642	0.0046642	-2.0530383	TXNDC17	thioredoxin domain containing 17
TC15001906.hg.1	-0.4390989	1.127539	-3.776185	0.0046741	0.0046741	-2.0539039	—	—
TC06001029.hg.1	-0.4313437	5.261774	-3.774403	0.0046688	0.0046688	-2.0540368	KIAA1244	KIAA1244
TC19002443.hg.1	0.5791167	6.084506	3.774704	0.0046801	0.0046801	-2.0555213	—	—
TC10000458.hg.1	0.5847825	4.266346	3.776228	0.0046873	0.0046873	-2.0557802	FAM149B1	family with sequence similarity 149, member B1
TC17002207.hg.1	0.5718156	8.192704	3.772990	0.0046787	0.0046787	-2.0561903	—	—
TC06000622.hg.1	0.4706585	5.879496	3.772614	0.0046814	0.0046814	-2.0567630	—	—
TC0X001393.hg.1	0.6539994	5.294348	3.781159	0.0047156	0.0047156	-2.0573462	MIR503	microRNA 503
TC0X001668.hg.1	0.3967056	4.677332	3.772174	0.0046845	0.0046845	-2.0574339	—	—
TC0X000066.hg.1	0.7977898	7.590284	3.795595	0.0047936	0.0047936	-2.0611596	MOSPD2	motile sperm domain containing 2
TC05001202.hg.1	0.5847470	2.800639	3.773873	0.0047296	0.0047296	-2.0630383	—	—
TC13001031.hg.1	-0.7289335	7.197407	-3.781234	0.0047563	0.0047563	-2.0631012	COG6	component of oligomeric golgi complex 6
TC09002383.hg.1	0.6100978	2.617777	3.776546	0.0047413	0.0047413	-2.0633419	RFX3	regulatory factor X, 3 (influences HLA class II expression)
TC19000924.hg.1	0.5620761	6.941080	3.767162	0.0047200	0.0047200	-2.0650741	ZNF667-AS1	ZNF667 antisense RNA 1 (head to head)
TC07000825.hg.1	0.4948736	6.427338	3.767006	0.0047211	0.0047211	-2.0653106	—	—
TC03000676.hg.1	-0.4904489	6.323826	-3.766708	0.0047232	0.0047232	-2.0657658	LOC90246	uncharacterized LOC90246
TC07001005.hg.1	0.5178822	4.368685	3.766431	0.0047252	0.0047252	-2.0661887	GIMAP2	GTPase, IMAP family member 2
TC12001863.hg.1	0.5011089	5.142550	3.766335	0.0047259	0.0047259	-2.0663342	RNA5SP366	RNA, 5S ribosomal pseudogene 366
3295148_st	0.6847210	7.745402	3.771780	0.0047460	0.0047460	-2.0664355	—	—
TC15000011.hg.1	0.6486876	4.445494	3.774289	0.0047643	0.0047643	-2.0677490	RNU6-498P	RNA, U6 small nuclear 498, pseudogene
TC15000014.hg.1	0.6486876	4.445494	3.774289	0.0047643	0.0047643	-2.0677490	RNU6-1235P	RNA, U6 small nuclear 1235, pseudogene
TC17001862.hg.1	0.4963839	6.842841	3.764944	0.0047358	0.0047358	-2.0684552	NAT9	N-acetyltransferase 9 (GCN5-related, putative)
TC0X000546.hg.1	0.4407841	4.382444	3.764209	0.0047410	0.0047410	-2.0695770	ALG13	ALG13, UDP-N-acetylglucosaminyltransferase subunit
TC10000761.hg.1	0.4986722	7.901630	3.764119	0.0047417	0.0047417	-2.0697140	RNU6-43P	RNA, U6 small nuclear 43, pseudogene
TC15000743.hg.1	0.6368139	5.031158	3.771110	0.0047723	0.0047723	-2.0704976	—	—
TC08000549.hg.1	0.6151266	5.103238	3.768697	0.0047665	0.0047665	-2.0708988	RNA5SP273	RNA, 5S ribosomal pseudogene 273
TC16000271.hg.1	-0.4415109	2.143585	-3.762989	0.0047498	0.0047498	-2.0714368	—	—
TC10001707.hg.1	0.5113487	8.705507	3.758848	0.0047795	0.0047795	-2.0777539	MCMBP	minichromosome maintenance complex binding protein
TC05000086.hg.1	-0.4368151	6.253104	-3.758812	0.0047798	0.0047798	-2.0778077	OTULIN	OTU deubiquitinase with linear linkage specificity
TC19002270.hg.1	0.4435556	10.158971	3.757656	0.0047881	0.0047881	-2.0795723	—	—
TC14001159.hg.1	0.5089290	7.060349	3.757610	0.0047884	0.0047884	-2.0796419	ATG14	autophagy related 14
TC0X002050.hg.1	0.6677452	5.121862	3.769113	0.0048430	0.0048430	-2.0814091	—	—
TC02003767.hg.1	-0.6700462	8.602713	-3.760584	0.0048249	0.0048249	-2.0832250	CASP8	caspase 8, apoptosis-related cysteine peptidase
TC10001315.hg.1	-0.4480295	4.549223	-3.754890	0.0048081	0.0048081	-2.0837927	SLC16A9	solute carrier family 16, member 9
TC13000137.hg.1	-0.6626485	6.782524	-3.759950	0.0048310	0.0048310	-2.0844059	COG6	component of oligomeric golgi complex 6
TC6_qbl_hap6000219.hg.1	-0.4747493	7.292603	-3.754434	0.0048114	0.0048114	-2.0844885	HLA-H	major histocompatibility complex, class I, H (pseudogene)
TC19001965.hg.1	-0.3850340	2.607641	-3.754088	0.0048139	0.0048139	-2.0850163	—	—
TC07001221.hg.1	-0.4797763	5.634436	-3.753925	0.0048151	0.0048151	-2.0852653	HOXA5	homeobox A5
TC11002768.hg.1	-0.4615437	6.263990	-3.753286	0.0048198	0.0048198	-2.0862418	FAM86C1	family with sequence similarity 86, member C1
TC14001365.hg.1	0.5477142	3.004024	3.754143	0.0048318	0.0048318	-2.0874764	DIO2	deiodinase, iodothyronine, type II
TC08001007.hg.1	0.4044355	3.019989	3.752281	0.0048271	0.0048271	-2.0877756	MSR1	macrophage scavenger receptor 1
TC10000460.hg.1	0.4828365	5.776352	3.750939	0.0048369	0.0048369	-2.0898234	LOC101929112	uncharacterized LOC101929112
TC03000366.hg.1	0.4378324	1.512878	3.750207	0.0048422	0.0048422	-2.0909407	—	—
TC03001546.hg.1	-0.4258456	5.913799	-3.750015	0.0048436	0.0048436	-2.0912346	FOXP1	forkhead box P1
TC17001617.hg.1	0.6942503	5.838939	3.765128	0.0049019	0.0049019	-2.0915702	ARL17A	ADP-ribosylation factor-like 17A
TC05001172.hg.1	-0.4345405	6.035627	-3.749131	0.0048501	0.0048501	-2.0925830	ANKH	ANKH inorganic pyrophosphate transport regulator
TC05000782.hg.1	-0.5137414	5.403492	-3.748565	0.0048542	0.0048542	-2.0934486	ARHGAP26	Rho GTPase activating protein 26
TC04002911.hg.1	-0.5072144	6.434746	-3.748456	0.0048550	0.0048550	-2.0936151	FAM193A	family with sequence similarity 193, member A
TC15000065.hg.1	0.4532741	7.374833	3.748328	0.0048560	0.0048560	-2.0938094	SNORD116-20	small nucleolar RNA, C/D box 116-20
TC09001339.hg.1	0.4545776	6.731919	3.745798	0.0048746	0.0048746	-2.0976731	IPPK	inositol 1,3,4,5,6-pentakisphosphate 2-kinase
TC09002693.hg.1	0.5507361	6.455381	3.745656	0.0048756	0.0048756	-2.0978901	XPA	xeroderma pigmentosum, complementation group A
TC15000847.hg.1	0.6434879	5.654260	3.753050	0.0049033	0.0049033	-2.0979033	—	—
TC07001125.hg.1	0.4049053	3.520139	3.744679	0.0048828	0.0048828	-2.0993817	—	—
TC01003151.hg.1	0.7641811	7.163921	3.764251	0.0049601	0.0049601	-2.0999492	—	—
TC01003153.hg.1	0.7641811	7.163921	3.764251	0.0049601	0.0049601	-2.0999492	—	—
TC16000880.hg.1	0.4395513	2.966340	3.743972	0.0048880	0.0048880	-2.1004620	—	—
TC01004080.hg.1	-0.4028107	2.814675	-3.743209	0.0048936	0.0048936	-2.1016269	OR11L1	olfactory receptor, family 11, subfamily L, member 1
TC12001720.hg.1	-0.5652233	1.809723	-3.752666	0.0049527	0.0049527	-2.1048419	—	—
TC02003503.hg.1	0.4515768	4.034330	3.741018	0.0049099	0.0049099	-2.1049741	MERTK	MER proto-oncogene, tyrosine kinase
TC13000235.hg.1	0.5511017	4.728384	3.741623	0.0049189	0.0049189	-2.1058995	RNA5SP30	RNA, 5S ribosomal pseudogene 30
TC21000450.hg.1	-0.4155858	3.475230	-3.740058	0.0049170	0.0049170	-2.1064415	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog
TC16000886.hg.1	0.6517815	6.202459	3.747358	0.0049453	0.0049453	-2.1065486	ABCC6P2	ATP-binding cassette, sub-family C, member 6 pseudogene 2
TC19002254.hg.1	0.5447362	6.843599	3.739905	0.0049181	0.0049181	-2.1066751	ZNF667-AS1	ZNF667 antisense RNA 1 (head to head)
TC09002641.hg.1	-0.4241194	2.643924	-3.739845	0.0049186	0.0049186	-2.1067671	—	—
TC15002660.hg.1	-0.4948597	2.761261	-3.739687	0.0049198	0.0049198	-2.1070083	—	—
TC03002529.hg.1	-0.4992486	6.318231	-3.739598	0.0049204	0.0049204	-2.1071438	—	—
TC12002908.hg.1	0.5964246	8.100193	3.739090	0.0049242	0.0049242	-2.1079205	RNF41	ring finger protein 41, E3 ubiquitin protein ligase
TC07002049.hg.1	-0.5715624	4.869012	-3.741371	0.0049356	0.0049356	-2.1082967	AC073236.3	novel transcript
TC12000612.hg.1	0.5011485	7.511257	3.738440	0.0049290	0.0049290	-2.1089128	YEATS4	YEATS domain containing 4
PSR19027720.hg.1	0.4394190	10.413177	3.737550	0.0049357	0.0049357	-2.1102742	—	—
TC01003995.hg.1	-0.5677351	5.095603	-3.740027	0.0049456	0.0049456	-2.1103469	GNG4	guanine nucleotide binding protein (G protein), gamma 4
TC04001383.hg.1	-0.4853271	7.645492	-3.736866	0.0049408	0.0049408	-2.1113185	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
TC0X001373.hg.1	-0.4181741	3.638197	-3.736142	0.0049462	0.0049462	-2.1124260	USP26	ubiquitin specific peptidase 26
TC01001209.hg.1	0.4579794	6.513984	3.735875	0.0049482	0.0049482	-2.1128340	PSMB4	proteasome (prosome, macropain) subunit, beta type, 4
TC08002561.hg.1	-0.4097974	3.926254	-3.735584	0.0049504	0.0049504	-2.1132784	LOC100133669	uncharacterized LOC100133669
TC05001261.hg.1	-0.5567701	5.481159	-3.736179	0.0049544	0.0049544	-2.1135257	PRLR	prolactin receptor
TC04000699.hg.1	-0.4206402	5.411432	-3.735126	0.0049538	0.0049538	-2.1139783	GAB1	GRB2-associated binding protein 1
TC10001617.hg.1	0.4616078	8.260730	3.732878	0.0049706	0.0049706	-2.1174148	LDB1	LIM domain binding 1
TC01006059.hg.1	0.4481677	6.296706	3.732348	0.0049746	0.0049746	-2.1182249	—	—
TC19001055.hg.1	0.5512773	5.654061	3.730880	0.0049882	0.0049882	-2.1208033	SNORD37	small nucleolar RNA, C/D box 37
TC11001124.hg.1	0.4948796	3.856230	3.730358	0.0049896	0.0049896	-2.1212665	GRAMD1B	GRAM domain containing 1B
TC09002264.hg.1	-0.3925916	1.960243	-3.729650	0.0049950	0.0049950	-2.1223500	—	—

2. GFR vs. GF: GO enrichment analysis

Gather a set of background genes to compare

library(genefilter)
library(Biobase)
#make a list of diff genes
diff.probe <- subset(x = diff.strain)$probe
background.genes <- genefilter::genefinder(eset, as.character(diff.probe), method = "manhattan", scale = "none")
background.genes <- sapply(background.genes, function(x) x$indices)
background.genes <- as.vector(background.genes)
back.genes <- featureNames(project.bgcorrect.norm.avg)[background.genes]

Remove any differentially expressed genes from the background gene set and verify that it is correct: the diff set and the background set should have nothing in common.

back.genes <- setdiff(back.genes, diff.probe)
intersect(back.genes, diff.probe)

## character(0)

Examine mean intensity of the diff set, background set and all probes

library(cancerTiming)
fit.all <- topTable(fit, number = nrow(fit))
multidensity(list(
    all = fit.all[,"AveExpr"],
    fore = diff.strain[,"AveExpr"],  
    back = fit.all[rownames(fit.all) %in% back.genes, "AveExpr"]),
  col = c("#e46981", "#ae7ee2", "#a7ad4a"),
  xlab = "mean expression",
  main = "GFR vs GF: Differentially Expressed, Background, and All gene expression levels"
)

GFR vs. GF: GO pathway enrichment analysis

Is the differential expression set enriched in particular functional categories? This is why we have created a background gene set, so that we know the “typical” functional distribution of genes expressed at similar levels. We will connect the probe names to GO categories and run a few tests for pathway enrichment.

library(topGO)

gene.IDs <- rownames(eset)
in.universe <- gene.IDs %in% c(diff.probe,back.genes)
in.selection <- gene.IDs %in% diff.probe

all.genes <- in.selection[in.universe]
all.genes <- factor(as.integer(in.selection[in.universe]))
names(all.genes) <- gene.IDs[in.universe]

#this builds a database with all GO information related to our two test sets AND whether the gene is differentially expressed
top_GO_data <- new("topGOdata", ontology = "BP", allGenes = all.genes,
 nodeSize = 10, annot = annFUN.db, affyLib = "hta20transcriptcluster.db")

result_top_GO_elim <- 
  runTest(top_GO_data, algorithm = "elim", statistic = "Fisher")
result_top_GO_classic <- 
  runTest(top_GO_data, algorithm = "classic", statistic = "Fisher")

library(stringr)
res_top_GO <- GenTable(top_GO_data, Fisher.elim = result_top_GO_elim,
        Fisher.classic = result_top_GO_classic,
        orderBy = "Fisher.elim" , topNodes = 100)

genes_top_GO <- printGenes(top_GO_data, whichTerms = res_top_GO$GO.ID,
    chip = "hta20transcriptcluster.db", geneCutOff = 1000)

res_top_GO$sig_genes <- sapply(genes_top_GO, function(x){
                str_c(paste0(x[x$'raw p-value' == 2, "Symbol.id"],";"), 
                      collapse = "")
    })

res_top_GO <- res_top_GO[order(-res_top_GO$Significant / res_top_GO$Expected),]
kable(res_top_GO) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	GO.ID	Term	Annotated	Significant	Expected	Rank in Fisher.classic	Fisher.elim	Fisher.classic	sig_genes
6	GO:0051180	vitamin transport	12	9	2.27	73	3.9e-05	3.9e-05	SLC19A2;SLC5A6;LRP2;SLC5A6;FOLR1;FOLR1;SLC2A3;SLC2A3;SLC46A1;
13	GO:1903044	protein localization to membrane raft	11	8	2.08	107	0.00016	0.00016	FLOT1;CD24;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
24	GO:2000049	positive regulation of cell-cell adhesio…	10	7	1.90	169	0.00060	0.00060	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
25	GO:1902692	regulation of neuroblast proliferation	10	7	1.90	170	0.00060	0.00060	DISC1;VEGFC;PAX6;HIF1A;KCTD11;TGFB1;TGFB1;
26	GO:0034116	positive regulation of heterotypic cell-…	10	7	1.90	171	0.00060	0.00060	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
27	GO:0034141	positive regulation of toll-like recepto…	10	7	1.90	172	0.00060	0.00060	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
28	GO:0060353	regulation of cell adhesion molecule pro…	10	7	1.90	173	0.00060	0.00060	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
15	GO:0072337	modified amino acid transport	14	9	2.65	125	0.00024	0.00024	PDZK1;NA;SLC19A2;SLC5A6;LRP2;SLC5A6;FOLR1;FOLR1;SLC46A1;
42	GO:1901741	positive regulation of myoblast fusion	11	7	2.08	216	0.00139	0.00139	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
12	GO:0032225	regulation of synaptic transmission, dop…	16	10	3.03	106	0.00015	0.00015	SNCA;GDNF;FLOT1;TOR1A;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
32	GO:0086002	cardiac muscle cell action potential inv…	13	8	2.46	186	0.00084	0.00084	KCNJ3;FGF12;KCNN2;DSP;CACNA2D1;CACNA2D1;DSG2;DSC2;
33	GO:0001765	membrane raft assembly	13	8	2.46	187	0.00084	0.00084	FLOT1;EMP2;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
19	GO:0090313	regulation of protein targeting to membr…	15	9	2.84	156	0.00051	0.00051	PDZK1;NA;FYN;STOM;VAMP7;VAMP7;VAMP7;INPP5K;PRNP;
80	GO:0003177	pulmonary valve development	10	6	1.90	317	0.00477	0.00477	TGFB2;ROBO1;SLIT2;TBX20;BMP4;JAG1;
81	GO:0071677	positive regulation of mononuclear cell …	10	6	1.90	318	0.00477	0.00477	SERPINE1;MOSPD2;PDGFD;LGALS3;TGFB1;TGFB1;
82	GO:0032928	regulation of superoxide anion generatio…	10	6	1.90	319	0.00477	0.00477	MAPT;MAPT;MAPT;CD177;TGFB1;TGFB1;
83	GO:0072111	cell proliferation involved in kidney de…	10	6	1.90	320	0.00477	0.00477	CFLAR;PDGFRB;PDGFRB;PDGFD;BMP4;SERPINB7;
16	GO:0001755	neural crest cell migration	17	10	3.22	138	0.00030	0.00030	ACVR1;SEMA5A;SEMA5A;GDNF;SEMA3E;FOLR1;FOLR1;KITLG;BMP4;HIF1A;
64	GO:0014032	neural crest cell development	29	17	5.50	42	0.00269	2.4e-06	ACVR1;EDNRA;SEMA5A;SEMA5A;GDNF;FOXC1;FOXC1;FOXC1;SEMA3E;NRG1;RDH10;FOLR1;FOLR1;KITLG;BMP4;HIF1A;JAG1;
66	GO:0070528	protein kinase C signaling	12	7	2.27	269	0.00280	0.00280	FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
46	GO:0048643	positive regulation of skeletal muscle t…	14	8	2.65	229	0.00164	0.00164	FLOT1;MTM1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
2	GO:0002480	antigen processing and presentation of e…	53	30	10.04	8	1.0e-09	1.0e-09	HLA-F;HLA-H;HLA-C;HLA-B;NA;HLA-F;HLA-C;HLA-B;HLA-F;NA;HLA-F;HLA-H;HLA-A;NA;HLA-B;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;NA;HLA-F;HLA-A;HLA-C;HLA-B;HLA-H;
34	GO:1901385	regulation of voltage-gated calcium chan…	16	9	3.03	196	0.00097	0.00097	PDE4B;CACNB4;CACNA2D1;CACNA2D1;FMR1;FMR1;DMD;DMD;RRAD;
22	GO:0038084	vascular endothelial growth factor signa…	18	10	3.41	163	0.00057	0.00057	ROBO1;GAB1;ADAMTS3;VEGFC;PDGFRB;PDGFRB;FOXC1;FOXC1;FOXC1;NA;
14	GO:0090184	positive regulation of kidney developmen…	22	12	4.17	119	0.00020	0.00020	CFLAR;BASP1;PDGFRB;GDNF;PDGFRB;CD24;LGR4;PDGFD;BMP4;SERPINB7;TGFB1;TGFB1;
87	GO:1902667	regulation of axon guidance	13	7	2.46	325	0.00507	0.00507	BMPR2;SLIT2;SEMA5A;SEMA5A;TUBB2B;SEMA3E;MYCBP2;
88	GO:0072010	glomerular epithelium development	13	7	2.46	326	0.00507	0.00507	BASP1;FOXC1;FOXC1;FOXC1;CD24;BMP4;JAG1;
89	GO:0060441	epithelial tube branching involved in lu…	13	7	2.46	327	0.00507	0.00507	HOXA5;RDH10;BMP4;CTSH;CTSH;LAMA1;LAMA1;
90	GO:0046856	phosphatidylinositol dephosphorylation	13	7	2.46	328	0.00507	0.00507	SYNJ2;PIP4P2;OCRL;MTM1;MTMR1;INPP5F;INPP5K;
91	GO:1903115	regulation of actin filament-based movem…	13	7	2.46	329	0.00507	0.00507	PDE4B;TNNC1;DSP;PLN;STC1;DSG2;DSC2;
3	GO:0001916	positive regulation of T cell mediated c…	56	30	10.61	10	6.1e-09	6.1e-09	HLA-F;HLA-H;HLA-C;HLA-B;NA;HLA-F;HLA-C;HLA-B;HLA-F;NA;HLA-F;HLA-H;HLA-A;NA;HLA-B;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;NA;HLA-F;HLA-A;HLA-C;HLA-B;HLA-H;
7	GO:0014068	positive regulation of phosphatidylinosi…	28	15	5.31	76	4.2e-05	4.2e-05	TGFB2;PDGFC;PDGFC;PDGFRB;PDGFRB;FYN;GPER1;RELN;ANGPT1;PIK3AP1;PDGFD;IL18;ERBB3;ERBB3;ERBB3;
68	GO:0032835	glomerulus development	28	15	5.31	77	0.00286	4.2e-05	CFLAR;COL4A4;BASP1;PDGFRB;PDGFRB;FOXC1;FOXC1;FOXC1;ANGPT1;CD24;LGR4;PDGFD;BMP4;SERPINB7;JAG1;
69	GO:0071360	cellular response to exogenous dsRNA	15	8	2.84	273	0.00294	0.00294	IFIH1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
49	GO:0032967	positive regulation of collagen biosynth…	17	9	3.22	232	0.00171	0.00171	ITGA2;PDGFRB;PDGFRB;MYB;CREB3L1;BMP4;SERPINB7;TGFB1;TGFB1;
50	GO:0090279	regulation of calcium ion import	17	9	3.22	233	0.00171	0.00171	PDGFRB;PDGFRB;FYN;PLN;STC1;WNK3;LGALS3;CCL2;PRNP;
51	GO:0051181	cofactor transport	17	9	3.22	234	0.00171	0.00171	SLC19A2;SLC5A6;LRP2;SLC5A6;ABCG2;ABCG2;FOLR1;FOLR1;SLC46A1;
37	GO:0032728	positive regulation of interferon-beta p…	19	10	3.60	202	0.00100	0.00100	IFIH1;POLR3G;FLOT1;RIPK2;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
23	GO:0061098	positive regulation of protein tyrosine …	21	11	3.98	166	0.00059	0.00059	DOCK3;FYN;RELN;NRG1;CD24;NA;ERBB3;ERBB3;ERBB3;GPRC5B;PRNP;
30	GO:0002483	antigen processing and presentation of e…	74	38	14.02	4	0.00075	2.9e-10	HLA-F;TAP1;HLA-H;HLA-C;HLA-B;NA;TAP1;HLA-F;TAP1;HLA-C;HLA-B;HLA-F;NA;TAP1;HLA-F;HLA-H;HLA-A;TAP1;NA;HLA-B;TAP1;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;TAP1;NA;HLA-F;HLA-A;TAP1;HLA-C;HLA-B;HLA-H;
85	GO:0046967	cytosol to ER transport	16	8	3.03	323	0.00491	0.00491	TAP1;TAP1;TAP1;TAP1;TAP1;TAP1;TAP1;TAP1;
67	GO:2000826	regulation of heart morphogenesis	18	9	3.41	271	0.00285	0.00285	TGFB2;BMPR2;ACVR1;ROBO1;FOXC1;FOXC1;FOXC1;BMP4;JAG1;
47	GO:0051580	regulation of neurotransmitter uptake	20	10	3.79	230	0.00166	0.00166	SNCA;GDNF;FLOT1;TOR1A;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
48	GO:0006835	dicarboxylic acid transport	20	10	3.79	231	0.00166	0.00166	SLC19A2;LRP2;SNCA;SLC1A3;SLC25A14;ABCC2;FOLR1;FOLR1;SLC25A30;SLC46A1;
35	GO:0003179	heart valve morphogenesis	22	11	4.17	198	0.00097	0.00097	TGFB2;BMPR2;ACVR1;ROBO1;SLIT2;SOX4;TBX20;BMP4;TGFB1;TGFB1;JAG1;
36	GO:0050775	positive regulation of dendrite morphoge…	22	11	4.17	199	0.00097	0.00097	CUX1;RELN;CUX1;CDKL5;IL1RAPL1;VAMP7;PAK3;VAMP7;VAMP7;CAPRIN2;CAPRIN2;
17	GO:0098930	axonal transport	26	13	4.93	142	0.00034	0.00034	TRAK2;DST;DST;BLOC1S5;AP3M2;FMR1;FMR1;DLG2;HIF1A;MAP1A;MAPT;MAPT;MAPT;
1	GO:0002479	antigen processing and presentation of e…	83	41	15.73	3	2.7e-10	2.7e-10	ITGAV;ITGB5;HLA-F;TAP1;HLA-H;HLA-C;HLA-B;NA;IKBKG;TAP1;HLA-F;TAP1;HLA-C;HLA-B;HLA-F;NA;TAP1;HLA-F;HLA-H;HLA-A;TAP1;NA;HLA-B;TAP1;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;TAP1;NA;HLA-F;HLA-A;TAP1;HLA-C;HLA-B;HLA-H;
4	GO:0002476	antigen processing and presentation of e…	61	30	11.56	19	7.9e-08	7.9e-08	HLA-F;HLA-H;HLA-C;HLA-B;NA;HLA-F;HLA-C;HLA-B;HLA-F;NA;HLA-F;HLA-H;HLA-A;NA;HLA-B;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;NA;HLA-F;HLA-A;HLA-C;HLA-B;HLA-H;
20	GO:0006855	drug transmembrane transport	27	13	5.12	160	0.00054	0.00054	SLC19A2;LRP2;ABCG2;ABCG2;SLC1A3;SLC7A2;SLC7A2;SLC25A14;FOLR1;FOLR1;SLC7A1;SLC25A30;SLC46A1;
21	GO:0010718	positive regulation of epithelial to mes…	27	13	5.12	161	0.00054	0.00054	TGFB2;ACVR1;LEF1;DAB2;FOXC1;FOXC1;FOXC1;BAMBI;BMP4;TGFB1I1;TGFB1;TGFB1;JAG1;
45	GO:0030199	collagen fibril organization	23	11	4.36	221	0.00155	0.00155	DDR2;TGFB2;NA;COL5A2;COL3A1;COL3A1;ADAMTS3;FOXC1;FOXC1;FOXC1;COL14A1;
63	GO:0006956	complement activation	21	10	3.98	265	0.00264	0.00264	CFB;SCARA3;COLEC10;CLU;CFB;CFB;CFB;CFB;CFB;CFB;
9	GO:0048844	artery morphogenesis	38	18	7.20	87	6.2e-05	6.2e-05	TGFB2;NA;BMPR2;LRP2;COL3A1;COL3A1;HPGD;PDGFRB;PDGFRB;FOXC1;FOXC1;FOXC1;SOX4;ZMIZ1;FOLR1;FOLR1;BMP4;JAG1;
76	GO:0045104	intermediate filament cytoskeleton organ…	19	9	3.60	307	0.00452	0.00452	KLHL24;DSP;DST;DST;NA;PLEC;TOR1A;MTM1;INA;
77	GO:0006693	prostaglandin metabolic process	19	9	3.60	308	0.00452	0.00452	HPGD;ANXA1;PTGR1;AKR1C4;AKR1C2;AKR1C3;PTGR2;CES2;CES2;
11	GO:0060485	mesenchyme development	109	51	20.66	1	0.00011	2.3e-11	TGFB2;S100A4;BMPR2;ACVR1;ROBO1;PHLDB2;PHLDB2;LEF1;EDNRA;BASP1;SEMA5A;PDGFRB;SEMA5A;GDNF;PDGFRB;DAB2;FOXF2;FOXC1;FOXC1;FOXC1;HOXA5;SEMA3E;TBX20;NRG1;RDH10;NA;NA;NA;NA;NA;NA;TSPY1;NA;NA;BAMBI;NA;FOLR1;FOLR1;KITLG;ERBB3;LRP6;ERBB3;ERBB3;BMP4;HIF1A;TGFB1I1;RFLNB;RFLNB;TGFB1;TGFB1;JAG1;
43	GO:0022617	extracellular matrix disassembly	26	12	4.93	218	0.00141	0.00141	DDR2;FLOT1;HTRA1;LCP1;TGFB1;TGFB1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
59	GO:0001523	retinoid metabolic process	24	11	4.55	251	0.00238	0.00238	DHRS3;DHRS3;LRP2;RARRES2;RDH10;SDC2;PNPLA4;AKR1C4;CYP26A1;AKR1C1;AKR1C3;
29	GO:0003151	outflow tract morphogenesis	34	15	6.44	178	0.00066	0.00066	TGFB2;DHRS3;DHRS3;BMPR2;LRP2;ROBO1;FOXC1;FOXC1;FOXC1;TBX20;FOLR1;FOLR1;BMP4;HIF1A;JAG1;
71	GO:0060350	endochondral bone morphogenesis	25	11	4.74	286	0.00353	0.00353	THBS3;BMPR2;FOXC1;COL21A1;FOXC1;FOXC1;SCARA3;COL14A1;STC1;IMPAD1;BMP4;
98	GO:0003197	endocardial cushion development	23	10	4.36	344	0.00594	0.00594	TGFB2;BMPR2;ACVR1;ROBO1;TBX20;ERBB3;ERBB3;ERBB3;BMP4;JAG1;
92	GO:0035272	exocrine system development	26	11	4.93	331	0.00509	0.00509	TGFB2;FOXC1;FOXC1;FOXC1;PAX6;NTN4;RAB26;LAMA1;LAMA1;TGFB1;TGFB1;
62	GO:0034754	cellular hormone metabolic process	31	13	5.87	262	0.00261	0.00261	HSD3B1;DHRS3;DHRS3;HSD17B11;RDH10;PNPLA4;AKR1C4;SGPL1;CYP26A1;AKR1C2;AKR1C1;AKR1C3;HSD17B1;
5	GO:0060333	interferon-gamma-mediated signaling path…	93	39	17.62	28	2.2e-07	2.2e-07	HLA-F;HLA-DRA;HLA-H;HLA-DQB1;HLA-C;HLA-B;NA;OAS1;HLA-F;HLA-DRA;HLA-C;HLA-B;HLA-F;HLA-DRA;NA;HLA-F;HLA-H;HLA-A;HLA-DRA;NA;HLA-B;HLA-DRA;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;HLA-DRA;NA;HLA-B;HLA-B;NA;HLA-F;HLA-A;HLA-DRA;HLA-C;HLA-B;HLA-H;
18	GO:0060041	retina development in camera-type eye	43	18	8.15	152	0.00043	0.00043	CLIC4;TGFB2;BMPR2;MERTK;RPL24;NECTIN3;LPCAT1;PDGFRB;PDGFRB;TFAP2A;TBC1D32;HIPK2;PAX6;FZD4;LRP6;HIF1A;LAMA1;LAMA1;
40	GO:0030500	regulation of bone mineralization	36	15	6.82	213	0.00135	0.00135	ECM1;DDR2;BMPR2;ACVR1;ANKH;TFAP2A;TXLNG;MGP;MGP;BMP4;HIF1A;RFLNB;RFLNB;TGFB1;TGFB1;
41	GO:0003208	cardiac ventricle morphogenesis	36	15	6.82	214	0.00135	0.00135	TGFB2;LRP2;TNNC1;CPE;FOXC1;DSP;FOXC1;FOXC1;SOX4;TBX20;NRG1;HIF1A;TGFB1;TGFB1;JAG1;
38	GO:1901216	positive regulation of neuron death	39	16	7.39	205	0.00115	0.00115	TGFB2;CASP8;SNCA;TFAP2A;FYN;MYB;CLU;AIFM1;PAK3;DDIT4;EIF2S1;NQO1;MAPT;MAPT;MAPT;PRNP;
72	GO:0098661	inorganic anion transmembrane transport	32	13	6.06	289	0.00365	0.00365	CLIC4;GLRB;SLC1A3;GABRG2;ANKH;CLIC3;CLIC3;SLC25A14;NA;GABRA3;CLIC2;SLC25A30;PRNP;
73	GO:0097327	response to antineoplastic agent	32	13	6.06	290	0.00365	0.00365	RAP1A;CFLAR;CPS1;PTGR1;FMR1;FMR1;DDIT4;CDH1;TGFB1;TGFB1;DNMT3B;DNMT3B;HMOX1;
54	GO:0060415	muscle tissue morphogenesis	37	15	7.01	241	0.00188	0.00188	TGFB2;EGLN1;NA;LRP2;COL3A1;COL3A1;TNNC1;FOXC1;DSP;FOXC1;FOXC1;TBX20;NRG1;TGFB1;TGFB1;
100	GO:0035904	aorta development	30	12	5.69	351	0.00598	0.00598	TGFB2;LTBP1;NA;LRP2;COL3A1;COL3A1;ROBO1;ADAMTS6;PDGFRB;PDGFRB;SOX4;JAG1;
75	GO:0001676	long-chain fatty acid metabolic process	36	14	6.82	302	0.00416	0.00416	GSTM4;MGLL;HPGD;ACSL1;SLC27A6;ELOVL2;ACSL4;AKR1C3;FADS2;CPT1A;ACOT4;ACOT1;NA;SLC27A2;
52	GO:1905039	carboxylic acid transmembrane transport	44	17	8.34	236	0.00179	0.00179	SLC5A6;STK39;LRP2;SLC5A6;SLC6A6;SLC1A3;SLC7A2;SLC7A2;SLC25A14;FOLR1;CPT1A;FOLR1;SLC7A1;SLC25A30;SLC7A7;SLC16A3;SLC46A1;
99	GO:0060348	bone development	70	27	13.27	95	0.00597	9.4e-05	DHRS3;THBS3;DHRS3;BMPR2;FOXP1;FAT4;PDGFC;PDGFC;FOXC1;TFAP2A;COL21A1;FOXC1;FOXC1;SCARA3;COL14A1;STC1;IMPAD1;PLS3;ATP6AP1;LRP6;TTC9;BMP4;FBN1;RFLNB;RFLNB;TGFB1;TGFB1;
44	GO:0048565	digestive tract development	47	18	8.91	220	0.00149	0.00149	TGFB2;NA;CPS1;COL3A1;COL3A1;FAT4;PDGFC;PDGFC;FOXF2;HOXA5;RARRES2;LGR4;BMP4;HIF1A;RBPMS2;TGFB1;TGFB1;VPS52;
8	GO:0008406	gonad development	79	30	14.97	82	5.5e-05	5.5e-05	TGFB2;LHX9;LRP2;TNFSF10;TNFSF10;SLIT2;BASP1;PDGFRB;PDGFRB;FOXC1;FOXC1;FOXC1;RDH10;LRRC6;PRDX4;ZFX;NA;NA;NA;NA;NA;NA;TSPY1;NA;NA;SGPL1;AKR1C3;FZD4;KITLG;EIF2B2;
93	GO:0098739	import across plasma membrane	37	14	7.01	336	0.00554	0.00554	KCNJ3;LRP2;SLC1A3;FYN;CACNA2D1;CACNA2D1;SLC7A2;SLC7A2;FOLR1;FOLR1;SLC7A1;FAM155A;SLC46A1;PRNP;
55	GO:0006919	activation of cysteine-type endopeptidas…	48	18	9.10	243	0.00197	0.00197	CASP8;ROBO1;TNFSF10;TNFSF10;SNCA;DLC1;BEX3;AIFM1;CASP12;IFI27;EGLN3;IFI27;CTSH;CTSH;MAPT;MAPT;MAPT;PMAIP1;
74	GO:0007156	homophilic cell adhesion via plasma memb…	43	16	8.15	292	0.00378	0.00378	CLSTN1;CLSTN2;ROBO1;NECTIN3;FAT4;PCDHB2;CDH12;CDH10;MYPN;FAT3;PCDH17;PCDH9;CDH1;DSG2;DSC3;DSC2;
70	GO:0032355	response to estradiol	46	17	8.72	277	0.00312	0.00312	CFLAR;TFPI;CASP8;TFPI;WNT7A;HPGD;ITGA2;PDGFRB;PDGFRB;GPER1;ANXA1;AIFM1;NQO1;TGFB1;TGFB1;DNMT3B;DNMT3B;
56	GO:0007498	mesoderm development	52	19	9.85	246	0.00213	0.00213	BMPR2;ACVR1;LEF1;ITGA2;FOXC1;FOXC1;FOXC1;MEST;TBX20;NA;NA;NA;NA;NA;NA;TSPY1;NA;NA;BMP4;
86	GO:0097553	calcium ion transmembrane import into cy…	44	16	8.34	324	0.00492	0.00492	TRPC1;SNCA;ITPR3;FYN;PLN;GPER1;CACNA2D1;CACNA2D1;CLIC2;DMD;DMD;FAM155A;RASA3;TGFB1;TGFB1;PRNP;
10	GO:0060337	type I interferon signaling pathway	91	33	17.24	89	7.0e-05	7.0e-05	HLA-F;HLA-H;HLA-C;HLA-B;NA;OAS1;IFI27;IFI27;HLA-F;HLA-C;HLA-B;HLA-F;NA;HLA-F;HLA-H;HLA-A;NA;HLA-B;NA;HLA-B;HLA-F;HLA-A;HLA-H;HLA-F;NA;HLA-B;HLA-B;NA;HLA-F;HLA-A;HLA-C;HLA-B;HLA-H;
39	GO:0007626	locomotory behavior	61	22	11.56	206	0.00119	0.00119	ALS2;HOXD10;LSAMP;FGF12;GLRB;SNCA;ANKH;GDNF;HIPK2;NRG1;PBX3;PBX3;HPRT1;INPP5F;PPP3CB;FZD4;USP2;EPS8;GNAO1;GPRC5B;GNAO1;C1QL1;
61	GO:0008016	regulation of heart contraction	72	24	13.64	257	0.00253	0.00253	PDE4B;NPR1;TGFB2;KCNJ3;TRPC1;PDE5A;KCNN2;DSP;ITPR3;BVES;PLN;CACNA2D1;CACNA2D1;STC1;ACE2;CLIC2;DMD;DMD;RNLS;SPX;GNAO1;GNAO1;DSG2;DSC2;
94	GO:0050806	positive regulation of synaptic transmis…	60	20	11.37	337	0.00559	0.00559	CLSTN1;CREB1;CLSTN2;WNT7A;SNCA;SLC1A3;ITPR3;FLOT1;GPER1;RELN;FMR1;FMR1;LGI1;PRNP;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
97	GO:0090288	negative regulation of cellular response…	64	21	12.13	340	0.00563	0.00563	LTBP1;CFLAR;LRP2;SLIT2;ADAMTS12;ADAMTS12;HIPK2;CHRDL1;NA;MIR503;BAMBI;HTRA1;CREB3L1;PPM1A;PPM1A;FBN1;RBPMS2;TGFB1I1;ONECUT2;TGFB1;TGFB1;
78	GO:0007219	Notch signaling pathway	71	23	13.45	314	0.00462	0.00462	TGFB2;WDR12;SUSD5;ROBO1;GATA2;FAT4;SORBS2;SORBS2;IL6ST;FOXC1;BEND6;FOXC1;FOXC1;PLN;GALNT11;NKAP;HIF1AN;ZMIZ1;DTX4;NR1H4;TGFB1;TGFB1;JAG1;
79	GO:0071229	cellular response to acid chemical	71	23	13.45	315	0.00462	0.00462	NA;CREB1;CPS1;COL5A2;COL3A1;COL3A1;PDGFC;PDGFC;CPEB4;FYN;MYB;PDK3;PDK3;AKR1C4;AKR1C2;AKR1C1;AKR1C3;FOLR1;CPT1A;FZD4;PDGFD;FOLR1;NR1H4;
96	GO:0045807	positive regulation of endocytosis	68	22	12.89	339	0.00563	0.00563	RAP1A;ITGAV;MERTK;GATA2;SNCA;ITGA2;DAB2;FLOT1;SERPINE1;ANGPT1;CLU;DNM1;TOR1A;FMR1;FMR1;CCL2;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
60	GO:0043270	positive regulation of ion transport	92	29	17.43	256	0.00250	0.00250	PDZK1;NA;STK39;TRPC1;FGF12;COX17;ATP8A1;SNCA;GLRX;PDGFRB;GDNF;PDGFRB;GPER1;CACNA2D1;RELN;CACNA2D1;STC1;FHL1;VAMP7;ACE2;WNK3;FHL1;VAMP7;DMD;DMD;VAMP7;KCNC1;LGALS3;CCL2;
58	GO:0097191	extrinsic apoptotic signaling pathway	108	33	20.47	248	0.00232	0.00232	G0S2;TGFB2;SORT1;G0S2;ITGAV;CFLAR;STRADB;ACVR1;CASP8;TNFSF10;TNFSF10;GDNF;EYA4;FYN;EYA4;GPER1;SERPINE1;ZC3HC1;BEX3;KITLG;ERBB3;ERBB3;RNF41;ERBB3;IFI27;BMP4;SGPP1;LGALS3;IFI27;PMAIP1;TGFB1;TGFB1;HMOX1;
57	GO:0050727	regulation of inflammatory response	120	36	22.74	247	0.00215	0.00215	PSMB4;STK39;FOXP1;MGLL;SNCA;OTULIN;ITGA2;ADAMTS12;IL6ST;ADAMTS12;CFB;GPER1;SERPINE1;SLC7A2;SLC7A2;CLU;ANXA1;XIAP;VAMP7;ACE2;XIAP;VAMP7;VAMP7;NA;PIK3AP1;SAA1;IL18;SAA1;NR1H4;GPRC5B;CFB;CFB;CFB;CFB;CFB;CFB;
84	GO:0045087	innate immune response	351	104	66.51	33	0.00489	4.1e-07	GBP4;LYST;IFIH1;CASP8;TRIM59;SNCA;OTULIN;POLR3G;HIST1H2BI;HLA-F;HLA-DRA;HIST1H2BK;FLOT1;FYN;HLA-H;HLA-DQB1;HLA-C;HLA-B;NA;CFB;GPER1;RARRES2;MUC3A;SCARA3;COLEC10;DEFB1;RIPK2;CLU;ANXA1;XIAP;HMGB3;VAMP7;RPS6KA3;NA;IKBKG;PAK3;XIAP;HMGB3;VAMP7;VAMP7;PIK3AP1;SAA1;MUC15;LGR4;IL18;SAA1;NR1H4;OAS1;KLRC2;IFI27;LGALS3;IFI27;RASGRP1;CCL2;RNF125;MALT1;CD177;TGFB1;NA;TGFB1;SLPI;HLA-F;HLA-DRA;FLOT1;HLA-C;HLA-B;CFB;HLA-F;HLA-DRA;FLOT1;NA;CFB;HLA-F;HLA-H;HLA-A;HLA-DRA;FLOT1;NA;HLA-B;CFB;HLA-DRA;FLOT1;NA;HLA-B;HLA-F;HLA-A;HLA-H;CFB;HLA-F;HLA-DRA;FLOT1;NA;HLA-B;HLA-B;NA;CFB;HLA-F;HLA-A;HLA-DRA;FLOT1;HLA-C;HLA-B;CFB;HLA-H;
31	GO:0002682	regulation of immune system process	544	161	103.09	2	0.00083	1.8e-10	PDE4B;RAP1A;ECM1;PSMB4;TGFB2;NA;NA;NA;CREB1;IFIH1;STK39;WIPF1;MERTK;COL3A1;COL3A1;CASP8;FOXP1;GATA2;SLIT2;BANK1;SNCA;LEF1;VEGFC;PDE5A;OTULIN;ITGA2;IL31RA;POLR3G;MYO10;IL6ST;FOXC1;HIST1H3A;BTN2A1;HLA-F;HLA-DRA;FLOT1;FYN;FOXC1;FOXC1;HLA-H;MYB;HLA-DQB1;HLA-C;HLA-B;NA;CFB;GPER1;SERPINE1;HOXA5;RARRES2;MUC3A;SLC7A2;SCARA3;COLEC10;MTUS1;TOX;ANGPT1;SLC7A2;RIPK2;CLU;ANXA1;NA;MOSPD2;XIAP;HMGB3;VAMP7;RPS6KA3;NKAP;ATP11C;CD99L2;IKBKG;MPP1;PAK3;XIAP;HMGB3;ATP6AP1;VAMP7;VAMP7;CD24;MAPK8;HTRA1;PPP3CB;PIK3AP1;LDB1;ZMIZ1;MUC15;LGR4;PDGFD;IL18;NR1H4;KITLG;RNF41;CUL4A;CUL4A;ELF1;EIF2B2;BMP4;LGALS3;HIF1A;RASGRP1;FBN1;SPPL2A;CTSH;CTSH;GPRC5B;CCL2;EVI2B;RNF125;MALT1;SOCS6;CD177;TGFB1;CLPTM1;TGFB1;PRNP;PLCB1;JAG1;HMOX1;HLA-F;HLA-DRA;FLOT1;HLA-C;HLA-B;CFB;HLA-F;HLA-DRA;FLOT1;NA;CFB;HLA-F;HLA-H;HLA-A;HLA-DRA;FLOT1;NA;HLA-B;CFB;HLA-DRA;FLOT1;NA;HLA-B;HLA-F;HLA-A;HLA-H;CFB;HLA-F;HLA-DRA;FLOT1;NA;HLA-B;HLA-B;NA;CFB;HLA-F;HLA-A;HLA-DRA;FLOT1;HLA-C;HLA-B;CFB;HLA-H;
53	GO:0006470	protein dephosphorylation	140	41	26.53	238	0.00182	0.00182	PTPRF;PPP2R5A;CAMTA1;PTPN4;PTPN4;CTDSPL;PTPRG;PPP2R3A;PPM1K;PPM1K;PDGFRB;PDGFRB;PTP4A1;EYA4;PTPRK;PTP4A1;EYA4;LMTK2;IGFBP3;DLC1;MTM1;MTMR1;DUSP9;MINPP1;SHOC2;PPP3CB;PPP1R3C;PPP2R5B;NUAK1;CDKN3;PPM1A;PPP2R5E;LGALS3;PPM1A;PTPN9;DUSP14;PPM1E;RPRD1A;TGFB1;TGFB1;TPTE;
95	GO:0007155	cell adhesion	503	128	95.32	99	0.00562	0.00010	PTPRF;ANXA9;DDR2;TGFB2;TESK2;TACSTD2;THBS3;CSRP1;CLSTN1;EPCAM;ITGAV;NA;ACKR3;ACVR1;MERTK;COL3A1;COL3A1;CLSTN2;LPP;SUSD5;ROBO1;ABI3BP;CCDC80;LSAMP;ITGB5;NECTIN3;PHLDB2;LPP;PHLDB2;FAT4;LEF1;PDE5A;ITGA2;PCDHB2;TENM2;SEMA5A;MYO10;CDH12;CDH10;ADAMTS12;IL6ST;EDIL3;SEMA5A;ADAMTS12;DSP;FLOT1;DST;BVES;FYN;PTPRK;MYB;DST;TRIP6;SERPINE1;NA;SEMA3E;RELN;COL14A1;DLC1;ANGPT1;TSTA3;RIPK2;ANXA1;ECM2;TOR1A;IL1RAPL1;ANOS1;NKAP;MIR503;CD99L2;PAK3;CD24;NLGN4Y;MYPN;PLAU;LDB1;ZMIZ1;PDE3B;SAA1;RHOD;FAT3;NA;DLG2;FZD4;IL18;SAA1;STAB2;KITLG;NUAK1;ERBB3;LRP6;ERBB3;ERBB3;PCDH17;ITGBL1;PCDH9;ITGBL1;ARHGAP5;BMP4;ARHGAP5;LGALS3;RASGRP1;FBN1;TLN2;TGFB1I1;CDH1;EMP2;CCL2;DSG2;ONECUT2;MALT1;LAMA1;DSC3;DSC2;SOCS6;LAMA1;CD177;TGFB1;NA;TGFB1;PRNP;JAG1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;FLOT1;
65	GO:0007166	cell surface receptor signaling pathway	1050	264	198.98	15	0.00270	2.5e-08	CDA;PTPRF;ZFYVE9;PDE4B;RAP1A;ECM1;NPR1;DDR2;MPZL1;G0S2;TGFB2;TNFRSF9;TACSTD2;SORT1;TXLNA;G0S2;DISC1;LTBP1;ITGAV;NA;CFLAR;STRADB;BMPR2;CREB1;ACKR3;ACVR1;STK39;LRP2;WIPF1;CHN1;TMEM237;WDR12;MERTK;COL3A1;COL3A1;CASP8;CHN1;PTPRG;KLHL24;WNT7A;SUSD5;ROBO1;ITGB5;GATA2;TNFSF10;FGF12;TNFSF10;SLIT2;FAT4;GAB1;GLRB;CPE;EPHA5;ADAMTS3;SNCA;LEF1;PDGFC;HPGD;VEGFC;ACSL1;SORBS2;PDGFC;SORBS2;OTULIN;ITGA2;IL31RA;CPEB4;SEMA5A;MYO10;ADAMTS12;PRLR;IL6ST;PDGFRB;SEMA5A;ADAMTS12;GDNF;PDGFRB;DAB2;FOXC1;HIST1H3A;BTN2A1;HLA-F;HLA-DRA;ANKS1A;BEND6;EYA4;IGF2R;DST;TBX18;FYN;TBC1D32;PTPRK;FOXC1;FOXC1;SOX4;HLA-H;PLN;EYA4;LTB;HLA-DQB1;DST;HLA-C;HLA-B;NA;GPER1;SERPINE1;GALNT11;IGFBP3;SEMA3E;RELN;ZC3HC1;HIPK2;MUC3A;TBX20;PDGFRL;NRG1;SDC2;LY6E;TNFRSF10D;ANGPT1;AGO2;RIPK2;ANXA1;DNM1;CSF2RA;PORCN;FOXO4;BEX3;IL13RA1;ZBTB33;XIAP;FMR1;NSDHL;ANOS1;CHRDL1;NKAP;NA;MIR503;IKBKG;CSF2RA;PAK3;XIAP;FMR1;ATP6AP1;RNF113A;TSPAN7;CSF2RA;CD24;BAMBI;MAPK8;BICC1;SGPL1;DDIT4;HIF1AN;NA;SHOC2;HTRA1;PPP3CB;LDB1;ZMIZ1;SAA1;CREB3L1;POLR2G;PPP2R5B;FOLR1;AMOTL1;MUC15;LGR4;PAX6;C2CD3;FZD4;PDGFD;IL18;SAA1;DTX4;FOLR1;C2CD3;NR1H4;OAS1;EPS8;CAPRIN2;KITLG;ERBB3;LRP6;CAPRIN2;ERBB3;RNF41;ERBB3;ITGBL1;CENPJ;ELF1;LCP1;DZIP1;ITGBL1;DAAM1;PPM1A;EIF2B2;IFI27;BMP4;SGPP1;LGALS3;DAAM1;PPM1A;IFI27;HIF1A;FBN1;SPPL2A;RBPMS2;INSYN1;TGFB1I1;GNAO1;EMP2;GPRC5B;MLKL;

write.csv(res_top_GO, "nested_interactions/GFR.GO.pathway.enrichment.csv")

This is a ranking of which GO terms are enriched according to two different testing strategies, elim and Fisher.classic. these are, roughly, probability scores and can be broadly interpreted the same way as p-scores.

GFR vs. GF: Visualizing the GO results:

nodes <- showSigOfNodes(top_GO_data, score(result_top_GO_elim), firstSigNodes = 3,
               useInfo = 'def')

png("nested_interactions/GFR.GO.pathway.enrichment.nodes.png")
nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 48 
## Number of Edges = 96 
## 
## $complete.dag
## [1] "A graph with 48 nodes."

dev.off()

## png 
##   2

nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 48 
## Number of Edges = 96 
## 
## $complete.dag
## [1] "A graph with 48 nodes."

3. GFR vs. GF: Pathway enrichment analysis via Reactome

map DE genes to Entrez, then reactome pathways, and perform pathway enrichment:

library(reactome.db)
library(DOSE)
library(ReactomePA)
entrez_ids <- mapIds(hta20transcriptcluster.db, 
      keys = rownames(eset), 
      keytype = "PROBEID",
      column = "ENTREZID",
      multiVals = "first")

reactome_enrich <- enrichPathway(gene = entrez_ids[diff.probe], 
                                universe = entrez_ids[c(diff.probe, 
                                                        back.genes)],
                                organism = "human",
                                pvalueCutoff = 0.05, pAdjustMethod = "none",
                                qvalueCutoff = 1, 
                                readable = TRUE)

reactome_enrich@result$Description <- paste0(str_sub(
                                    reactome_enrich@result$Description, 1, 20),
                                    "...")

write.csv(as.data.frame(reactome_enrich), "nested_interactions/GFR.reactome.pathway.enrichment.png")

kable(reactome_enrich) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
R-HSA-111465	R-HSA-111465	Apoptotic cleavage o…	9/567	16/3108	0.0007101	0.0007101	0.3107918	DSP/CDH1/MAPT/SATB1/TJP2/BCAP31/DSG2/PLEC/CASP8	9
R-HSA-3000171	R-HSA-3000171	Non-integrin membran…	12/567	26/3108	0.0009650	0.0009650	0.3107918	COL5A2/COL4A4/NTN4/COL3A1/DMD/ITGA2/SDC2/LAMA1/TGFB1/ITGB5/ITGAV/DDR2	12
R-HSA-194068	R-HSA-194068	Bile acid and bile s…	8/567	14/3108	0.0012482	0.0012482	0.3107918	SLC27A2/AKR1C2/AKR1C1/NR1H4/AKR1C4/AKR1C3/ABCC3/CYP7B1	8
R-HSA-192105	R-HSA-192105	Synthesis of bile ac…	7/567	12/3108	0.0021980	0.0021980	0.4104825	SLC27A2/AKR1C2/AKR1C1/NR1H4/AKR1C4/AKR1C3/CYP7B1	7
R-HSA-1474244	R-HSA-1474244	Extracellular matrix…	27/567	89/3108	0.0034070	0.0034070	0.5090040	COL5A2/COL4A4/NTN4/COL3A1/COL21A1/DMD/ITGA2/SDC2/LAMA1/DST/CDH1/TGFB1/ADAMTS16/COL14A1/LTBP1/HTRA1/PCOLCE2/ITGB5/ADAMTS3/FBN1/P3H2/BMP4/ITGAV/TGFB2/PLEC/DDR2/SERPINE1	27
R-HSA-983170	R-HSA-983170	Antigen Presentation…	7/567	14/3108	0.0067934	0.0067934	0.7043253	HLA-B/BCAP31/HLA-C/HLA-A/HLA-F/SEC24D/TAP1	7
R-HSA-5173105	R-HSA-5173105	O-linked glycosylati…	13/567	36/3108	0.0081918	0.0081918	0.7043253	ADAMTS12/MUC15/ADAMTS6/GALNT7/SEMA5A/C1GALT1C1/GALNT13/ADAMTS16/ADAMTS3/MUC3A/GALNTL5/GALNT11/ST3GAL4	13
R-HSA-373752	R-HSA-373752	Netrin-1 signaling…	8/567	18/3108	0.0091658	0.0091658	0.7043253	NTN4/FYN/ABLIM1/SLIT2/ROBO1/TRPC1/MAPK8/MYO10	8
R-HSA-2129379	R-HSA-2129379	Molecules associated…	7/567	15/3108	0.0107673	0.0107673	0.7043253	TGFB1/LTBP1/ITGB5/FBN1/BMP4/ITGAV/TGFB2	7
R-HSA-3000170	R-HSA-3000170	Syndecan interaction…	7/567	15/3108	0.0107673	0.0107673	0.7043253	COL5A2/COL3A1/ITGA2/SDC2/TGFB1/ITGB5/ITGAV	7
R-HSA-75153	R-HSA-75153	Apoptotic execution …	9/567	22/3108	0.0109191	0.0109191	0.7043253	DSP/CDH1/MAPT/SATB1/TJP2/BCAP31/DSG2/PLEC/CASP8	9
R-HSA-419037	R-HSA-419037	NCAM1 interactions…	6/567	12/3108	0.0122573	0.0122573	0.7043253	COL5A2/COL4A4/COL3A1/GDNF/PRNP/CACNB4	6
R-HSA-5362517	R-HSA-5362517	Signaling by Retinoi…	6/567	12/3108	0.0122573	0.0122573	0.7043253	RDH10/DHRS3/PDK3/CPT1A/CYP26A1/AKR1C3	6
R-HSA-3000178	R-HSA-3000178	ECM proteoglycans…	10/567	27/3108	0.0162012	0.0162012	0.7910726	COL5A2/COL4A4/COL3A1/ITGA2/LAMA1/TGFB1/ITGB5/ITGAV/TGFB2/SERPINE1	10
R-HSA-3906995	R-HSA-3906995	Diseases associated …	8/567	20/3108	0.0187917	0.0187917	0.7910726	ADAMTS12/MUC15/ADAMTS6/SEMA5A/C1GALT1C1/ADAMTS16/ADAMTS3/MUC3A	8
R-HSA-397014	R-HSA-397014	Muscle contraction…	15/567	48/3108	0.0198402	0.0198402	0.7910726	NPR1/DMD/CACNA2D1/CLIC2/ITGB5/CALD1/TNNC1/CACNG6/TRPC1/ITPR3/HIPK2/ANXA1/FGF12/CACNB4/PLN	15
R-HSA-112316	R-HSA-112316	Neuronal System…	23/567	83/3108	0.0207095	0.0207095	0.7910726	TSPAN7/GABRG2/RPS6KA3/GABRA3/CACNA2D1/SLC1A3/KCNJ3/SLITRK5/PLCB1/AKAP5/FLOT1/KCNN2/EPB41L3/KCNC1/GLRB/KCNS1/CREB1/DLG2/CACNB4/NLGN4Y/PTPRF/IL1RAPL1/GNG4	23
R-HSA-5083635	R-HSA-5083635	Defective B3GALTL ca…	5/567	10/3108	0.0223459	0.0223459	0.7910726	ADAMTS12/ADAMTS6/SEMA5A/ADAMTS16/ADAMTS3	5
R-HSA-5173214	R-HSA-5173214	O-glycosylation of T…	5/567	10/3108	0.0223459	0.0223459	0.7910726	ADAMTS12/ADAMTS6/SEMA5A/ADAMTS16/ADAMTS3	5
R-HSA-5213460	R-HSA-5213460	RIPK1-mediated regul…	5/567	10/3108	0.0223459	0.0223459	0.7910726	TNFSF10/XIAP/MLKL/CFLAR/CASP8	5
R-HSA-5218859	R-HSA-5218859	Regulated Necrosis…	5/567	10/3108	0.0223459	0.0223459	0.7910726	TNFSF10/XIAP/MLKL/CFLAR/CASP8	5
R-HSA-1566948	R-HSA-1566948	Elastic fibre format…	7/567	17/3108	0.0232980	0.0232980	0.7910726	TGFB1/LTBP1/ITGB5/FBN1/BMP4/ITGAV/TGFB2	7
R-HSA-1474290	R-HSA-1474290	Collagen formation…	10/567	29/3108	0.0272487	0.0272487	0.8323032	COL5A2/COL4A4/COL3A1/COL21A1/DST/COL14A1/PCOLCE2/ADAMTS3/P3H2/PLEC	10
R-HSA-2022090	R-HSA-2022090	Assembly of collagen…	6/567	14/3108	0.0287101	0.0287101	0.8323032	COL5A2/COL4A4/COL3A1/DST/COL14A1/PLEC	6
R-HSA-5357905	R-HSA-5357905	Regulation of TNFR1 …	6/567	14/3108	0.0287101	0.0287101	0.8323032	XIAP/USP2/IKBKG/SPPL2A/OTULIN/CASP8	6
R-HSA-556833	R-HSA-556833	Metabolism of lipids…	58/567	253/3108	0.0293220	0.0293220	0.8323032	SLC27A2/GALC/AKR1C2/AKR1C1/ACOT9/LPCAT1/LPCAT2/G0S2/SGPL1/MGLL/SYNJ2/CPT1A/HACD4/SMPD4/TPTE/RAB4A/ELOVL2/MTMR1/INPP5K/SPTSSA/ACSS3/HSD3B1/MED31/NR1H4/FADS2/ACOT4/ACSL1/ACSL4/SPTLC2/LRP2/FABP3/AKR1C4/SAMD8/OCRL/SGPP1/AKR1C3/NSDHL/MED30/CPNE7/MTMR10/PNPLA4/ABCC3/ACOT1/CYP7B1/MTM1/HPGD/PTGR1/HSD17B1/PRKAG2/CDS1/INPP5F/HSD17B11/SEC24D/SGMS1/PLBD1/ECI2/GSTM4/PTGR2	58
R-HSA-8957322	R-HSA-8957322	Metabolism of steroi…	14/567	46/3108	0.0300832	0.0300832	0.8323032	SLC27A2/AKR1C2/AKR1C1/HSD3B1/NR1H4/LRP2/AKR1C4/AKR1C3/NSDHL/ABCC3/CYP7B1/HSD17B1/HSD17B11/SEC24D	14
R-HSA-6781823	R-HSA-6781823	Formation of TC-NER …	8/567	22/3108	0.0340512	0.0340512	0.9084384	ERCC6/ERCC2/POLR2G/MNAT1/CUL4A/PPIE/CUL4B/XPA	8
R-HSA-202733	R-HSA-202733	Cell surface interac…	16/567	56/3108	0.0376722	0.0376722	0.9161877	FYN/SDC2/TSPAN7/ANGPT1/SLC7A7/PSG1/TGFB1/CD99L2/CD177/EPCAM/ITGAV/PSG2/TNFRSF10D/PSG9/SLC16A3/MERTK	16
R-HSA-8978868	R-HSA-8978868	Fatty acid metabolis…	16/567	56/3108	0.0376722	0.0376722	0.9161877	SLC27A2/ACOT9/CPT1A/HACD4/ELOVL2/FADS2/ACOT4/ACSL1/ACSL4/AKR1C3/ACOT1/HPGD/PTGR1/PRKAG2/ECI2/PTGR2	16
R-HSA-1660661	R-HSA-1660661	Sphingolipid de novo…	6/567	15/3108	0.0406719	0.0406719	0.9161877	SGPL1/SPTSSA/SPTLC2/SAMD8/SGPP1/SGMS1	6
R-HSA-112314	R-HSA-112314	Neurotransmitter rec…	11/567	35/3108	0.0413765	0.0413765	0.9161877	TSPAN7/GABRG2/RPS6KA3/GABRA3/KCNJ3/PLCB1/AKAP5/GLRB/CREB1/DLG2/GNG4	11
R-HSA-1650814	R-HSA-1650814	Collagen biosynthesi…	8/567	23/3108	0.0441536	0.0441536	0.9161877	COL5A2/COL4A4/COL3A1/COL21A1/COL14A1/PCOLCE2/ADAMTS3/P3H2	8
R-HSA-375165	R-HSA-375165	NCAM signaling for n…	8/567	23/3108	0.0441536	0.0441536	0.9161877	COL5A2/COL4A4/FYN/COL3A1/GDNF/PRNP/CREB1/CACNB4	8
R-HSA-6782135	R-HSA-6782135	Dual incision in TC-…	8/567	23/3108	0.0441536	0.0441536	0.9161877	ERCC6/ERCC2/POLR2G/MNAT1/CUL4A/PPIE/CUL4B/XPA	8
R-HSA-6782210	R-HSA-6782210	Gap-filling DNA repa…	8/567	23/3108	0.0441536	0.0441536	0.9161877	ERCC6/ERCC2/XRCC1/POLR2G/MNAT1/CUL4A/PPIE/CUL4B	8

GFR vs. GF: Visualizing reactome results

Barplots, showing reaction categories represented and their respective p-values:

png("nested_interactions/GFR.reactome.pathway.enrichment.barplot.png")
barplot(reactome_enrich)
dev.off()

## png 
##   2

barplot(reactome_enrich)

png("nested_interactions/GFR.reactome.pathway.enrichment.emapplot.png")
emapplot(reactome_enrich, showCategory = 20)
dev.off()

## png 
##   2

emapplot(reactome_enrich, showCategory = 20)

In this plot, color is p-value, size is proportional to the number of DE genes that mapped to the pathway, and the edge thickness is proportional to the number of shared genes between the units. This is useful for examining the interdependence of the pathways; which results should be taken more serioiusly, are independent? This particular plot shows the top ten most significant pathways, regardless of their p-values

B. GFR-specific treatment resposnes

1. GFR-specific treatment responses: Run “fit” algorithms and separate out the significantly different probes using a contrast set

Note that this is formatted to include LARGE but statistically insignificant results

with such a limited number of comparisons, classical false-discovery-rate correction of p-values is extremely strict, in this case omitting what appear to be fairly clear differences. We have only a 2 sample vs 2 sample system (two tGFRvscGFR vs tGFvscGF), which is very poor for t-testing.

eset <- project.bgcorrect.norm.avg.filt
fit <- lmFit(eset, design2)
fit <- eBayes(fit, trend=T, robust=T)
fit2 <- contrasts.fit(fit, c(0,0,0,-1,1))
fit2 <- eBayes(fit2)
diff.tGFR <- topTable(fit2, adjust.method = "none",p.value=.005,number=Inf, confint = T)
setDT(diff.tGFR, keep.rownames = TRUE)[]

##                            rn      logFC       CI.L        CI.R  AveExpr
##   1:  TC6_dbb_hap3000083.hg.1  1.7364258  1.0993543  2.37349730 4.021221
##   2:          TC06000399.hg.1  1.6602617  0.4638667  2.85665676 3.999679
##   3:  TC6_mcf_hap5000075.hg.1  1.6649864  0.8632248  2.46674797 4.117026
##   4:  TC6_qbl_hap6000081.hg.1  1.6649864  1.2774388  2.05253395 4.117026
##   5: TC6_ssto_hap7000076.hg.1  1.6649864  1.1830717  2.14690110 4.117026
##  ---                                                                    
## 264:          TC18000078.hg.1  0.7309407 -1.1873234  2.64920478 3.543635
## 265:               2960249_st  0.8375813  0.4485498  1.22661286 4.028793
## 266:          TC09000899.hg.1 -0.5741384 -0.9687868 -0.17948989 5.532533
## 267:          TC15001997.hg.1 -0.5373415 -1.1312311  0.05654816 2.426173
## 268:          TC10002574.hg.1 -1.0625140 -1.3988333 -0.72619462 4.520920
##              t      P.Value    adj.P.Val         B
##   1: 11.872761 2.427041e-06 2.427041e-06 -2.977216
##   2: 11.286359 3.558903e-06 3.558903e-06 -2.990068
##   3: 11.243423 3.662607e-06 3.662607e-06 -2.991081
##   4: 11.243423 3.662607e-06 3.662607e-06 -2.991081
##   5: 11.243423 3.662607e-06 3.662607e-06 -2.991081
##  ---                                              
## 264:  3.866516 4.811836e-03 4.811836e-03 -3.632407
## 265:  3.866076 4.814824e-03 4.814824e-03 -3.632514
## 266: -3.849624 4.927937e-03 4.927937e-03 -3.636527
## 267: -3.846983 4.946358e-03 4.946358e-03 -3.637173
## 268: -3.846481 4.949869e-03 4.949869e-03 -3.637296

colnames(diff.tGFR)[1] <- "probe"
diff.tGFR <- dplyr::left_join(diff.tGFR,probe.gene.map,by="probe")
diff.tGFR.size <- diff.tGFR[order(-diff.tGFR$logFC),]
write.csv(diff.tGFR, "nested_interactions/DE.genes.tGFR.specific.csv")
kable(diff.tGFR.size) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	probe	logFC	CI.L	CI.R	AveExpr	t	P.Value	adj.P.Val	B	name	description
216	TC10002568.hg.1	2.6618371	2.3234122	3.0002621	5.316601	4.009678	0.0039380	0.0039380	-3.598487	—	—
219	TC10002567.hg.1	2.5639951	1.9322096	3.1957805	3.893117	3.997068	0.0040077	0.0040077	-3.601404	—	—
8	47424360_st	2.4762003	2.1382360	2.8141647	2.704951	8.838574	0.0000219	0.0000219	-3.069890	—	—
86	TC01005754.hg.1	2.3954102	2.0097839	2.7810366	6.144722	4.872871	0.0012538	0.0012538	-3.427984	—	—
27	2985876_st	2.3472452	1.9877465	2.7067440	5.731316	5.646420	0.0004925	0.0004925	-3.315305	—	—
192	TC04000408.hg.1	2.1968195	1.6976787	2.6959603	3.856812	4.114278	0.0034081	0.0034081	-3.574803	CXCL8	chemokine (C-X-C motif) ligand 8
39	TC08001612.hg.1	2.1968151	1.7076873	2.6859430	3.636100	5.406042	0.0006526	0.0006526	-3.346958	—	—
152	47424061_st	2.1814129	1.5511749	2.8116509	2.169571	4.311166	0.0026077	0.0026077	-3.532630	—	—
193	TC02001364.hg.1	2.0166611	1.4981604	2.5351617	2.975513	4.103289	0.0034599	0.0034599	-3.577249	CCL20	chemokine (C-C motif) ligand 20
213	47421298_st	1.8389215	1.4510274	2.2268156	2.238743	4.024874	0.0038558	0.0038558	-3.594990	—	—
52	TC15000024.hg.1	1.8246391	1.2934242	2.3558539	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
53	TC15000148.hg.1	1.8246391	0.6281402	3.0211379	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
54	TC15000207.hg.1	1.8246391	0.5351687	3.1141094	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
55	TC15000238.hg.1	1.8246391	0.5856127	3.0636654	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
56	TC15000243.hg.1	1.8246391	0.6422300	3.0070482	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
57	TC15001014.hg.1	1.8246391	1.1622345	2.4870436	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
58	TC15001053.hg.1	1.8246391	1.2118636	2.4374145	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
59	TC15001115.hg.1	1.8246391	1.3989065	2.2503716	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
60	TC15001129.hg.1	1.8246391	1.4821773	2.1671009	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
61	TC15001157.hg.1	1.8246391	1.3631386	2.2861395	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
62	TC15001673.hg.1	1.8246391	1.2069452	2.4423329	4.616064	5.159258	0.0008785	0.0008785	-3.382484	—	—
15	TC0X001951.hg.1	1.8189778	0.1409378	3.4970177	4.444599	7.050275	0.0001098	0.0001098	-3.175732	—	—
181	47420665_st	1.8092450	1.3450078	2.2734822	2.108061	4.148134	0.0032534	0.0032534	-3.567331	—	—
1	TC6_dbb_hap3000083.hg.1	1.7364258	1.0993543	2.3734973	4.021221	11.872761	0.0000024	0.0000024	-2.977216	HLA-DRA	major histocompatibility complex, class II, DR alpha
6	TC6_mann_hap4000074.hg.1	1.6695281	1.1174258	2.2216305	4.118256	11.221229	0.0000037	0.0000037	-2.991608	HLA-DRA	major histocompatibility complex, class II, DR alpha
3	TC6_mcf_hap5000075.hg.1	1.6649864	0.8632248	2.4667480	4.117026	11.243423	0.0000037	0.0000037	-2.991081	HLA-DRA	major histocompatibility complex, class II, DR alpha
4	TC6_qbl_hap6000081.hg.1	1.6649864	1.2774388	2.0525339	4.117026	11.243423	0.0000037	0.0000037	-2.991081	HLA-DRA	major histocompatibility complex, class II, DR alpha
5	TC6_ssto_hap7000076.hg.1	1.6649864	1.1830717	2.1469011	4.117026	11.243423	0.0000037	0.0000037	-2.991081	HLA-DRA	major histocompatibility complex, class II, DR alpha
2	TC06000399.hg.1	1.6602617	0.4638667	2.8566568	3.999679	11.286359	0.0000036	0.0000036	-2.990068	HLA-DRA	major histocompatibility complex, class II, DR alpha
7	TC6_cox_hap2000090.hg.1	1.5800729	1.2093171	1.9508288	3.909857	9.980765	0.0000089	0.0000089	-3.026245	HLA-DRA	major histocompatibility complex, class II, DR alpha
28	TC18000797.hg.1	1.5432635	0.8699547	2.2165723	4.714361	5.606665	0.0005156	0.0005156	-3.320351	—	—
11	TC11003477.hg.1	1.5282861	1.1006127	1.9559596	3.516779	7.461492	0.0000738	0.0000738	-3.145915	SAA4	serum amyloid A4, constitutive
186	47421529_st	1.4851581	1.1532820	1.8170342	2.093812	4.138777	0.0032954	0.0032954	-3.569387	—	—
9	47420725_st	1.4615942	0.2358573	2.6873311	2.187253	8.014321	0.0000444	0.0000444	-3.111522	—	—
122	47421241_st	1.4341128	1.0509672	1.8172585	2.656520	4.517065	0.0019831	0.0019831	-3.491705	—	—
41	47423221_st	1.3390742	0.9718683	1.7062801	1.839781	5.336293	0.0007092	0.0007092	-3.356674	—	—
21	TC11001704.hg.1	1.3183269	0.5713715	2.0652822	1.914391	5.935725	0.0003545	0.0003545	-3.280681	—	—
87	47424055_st	1.2435919	0.8585630	1.6286208	1.433446	4.812428	0.0013536	0.0013536	-3.438222	—	—
108	TC02004032.hg.1	1.2272996	0.9082945	1.5463048	5.583444	4.608159	0.0017603	0.0017603	-3.474577	—	—
32	47424102_st	1.2059030	0.8023307	1.6094753	1.736368	5.491920	0.0005896	0.0005896	-3.335330	—	—
17	TC15001710.hg.1	1.1647771	0.3537955	1.9757587	6.540506	6.333301	0.0002295	0.0002295	-3.238546	—	—
230	3662480_st	1.1537652	-0.4136724	2.7212028	7.158878	3.964175	0.0041957	0.0041957	-3.609077	—	—
13	TC05001205.hg.1	1.1349197	0.4423473	1.8274920	5.223500	7.204022	0.0000945	0.0000945	-3.164114	CDH10	cadherin 10, type 2 (T2-cadherin)
103	3671548_st	1.0649464	0.6787711	1.4511218	4.824891	4.629049	0.0017132	0.0017132	-3.470731	—	—
45	TC18000331.hg.1	1.0513421	0.5571323	1.5455519	1.623643	5.295141	0.0007451	0.0007451	-3.362524	—	—
190	47419820_st	1.0132997	0.6249049	1.4016945	1.448899	4.124418	0.0033609	0.0033609	-3.572556	—	—
249	TC16001352.hg.1	1.0048251	0.4290848	1.5805654	2.211975	3.902030	0.0045772	0.0045772	-3.623827	—	—
51	47419687_st	0.9825656	0.5635360	1.4015953	1.488180	5.160640	0.0008770	0.0008770	-3.382276	—	—
83	TC15001949.hg.1	0.9796920	0.1588214	1.8005627	4.088601	4.898808	0.0012135	0.0012135	-3.423661	—	—
109	TC14001601.hg.1	0.9728365	0.5567958	1.3888772	3.884566	4.597682	0.0017845	0.0017845	-3.476517	—	—
142	TC08002373.hg.1	0.9540273	0.5458651	1.3621895	4.588725	4.371484	0.0024051	0.0024051	-3.520315	—	—
176	TC04002771.hg.1	0.9512695	0.1517570	1.7507821	5.089020	4.179653	0.0031162	0.0031162	-3.560458	ZNF827	zinc finger protein 827
236	TC11002216.hg.1	0.9475860	0.4715099	1.4236622	2.058663	3.939046	0.0043457	0.0043457	-3.615001	—	—
139	TC06000010.hg.1	0.9465836	0.0205074	1.8726599	5.812012	4.401504	0.0023107	0.0023107	-3.514287	FOXF2	forkhead box F2
88	TC08001992.hg.1	0.9397066	0.5326720	1.3467411	2.394108	4.796574	0.0013812	0.0013812	-3.440945	—	—
155	TC10001443.hg.1	0.9251172	0.1307247	1.7195097	3.773911	4.295429	0.0026635	0.0026635	-3.535889	—	—
115	TC01003878.hg.1	0.9204077	0.3223481	1.5184673	4.217955	4.543928	0.0019144	0.0019144	-3.486593	RNU6-1319P	RNA, U6 small nuclear 1319, pseudogene
116	TC01004037.hg.1	0.9204077	0.4671142	1.3737012	4.217955	4.543928	0.0019144	0.0019144	-3.486593	RNU6-747P	RNA, U6 small nuclear 747, pseudogene
117	TC07000284.hg.1	0.9204077	-0.5040319	2.3448473	4.217955	4.543928	0.0019144	0.0019144	-3.486593	RNU6-241P	RNA, U6 small nuclear 241, pseudogene
24	TC06002990.hg.1	0.9072919	0.3232665	1.4913174	7.095794	5.758820	0.0004328	0.0004328	-3.301424	GTF3C6	general transcription factor IIIC, polypeptide 6, alpha 35kDa
253	3676043_st	0.9067414	0.3841871	1.4292957	8.992440	3.896725	0.0046115	0.0046115	-3.625101	—	—
178	TC11001303.hg.1	0.9047489	0.4549491	1.3545486	2.343603	4.158016	0.0032097	0.0032097	-3.565167	RNU6-1143P	RNA, U6 small nuclear 1143, pseudogene
98	TC17001820.hg.1	0.9026516	0.4119203	1.3933828	5.551324	4.699852	0.0015633	0.0015633	-3.457915	SLC16A6	solute carrier family 16, member 6
101	PSR02023982.hg.1	0.8976339	0.4513194	1.3439483	4.041439	4.639484	0.0016902	0.0016902	-3.468821	—	—
23	TC12000656.hg.1	0.8888859	0.4151671	1.3626046	4.274430	5.813832	0.0004066	0.0004066	-3.294832	NAV3	neuron navigator 3
42	TC05002783.hg.1	0.8744668	0.3536503	1.3952833	5.483123	5.332880	0.0007121	0.0007121	-3.357156	—	—
72	TC19000303.hg.1	0.8677113	0.2438396	1.4915830	4.175099	5.085603	0.0009616	0.0009616	-3.393728	—	—
145	TC04001283.hg.1	0.8650210	0.3210424	1.4089997	3.787979	4.359749	0.0024431	0.0024431	-3.522689	CXCL5	chemokine (C-X-C motif) ligand 5
81	TC03001057.hg.1	0.8552271	0.4662935	1.2441608	2.999343	4.940008	0.0011523	0.0011523	-3.416879	RP11-655G22.1	novel trancript
31	TC03002727.hg.1	0.8472723	0.4164058	1.2781389	2.250786	5.509799	0.0005774	0.0005774	-3.332955	—	—
77	TC15000968.hg.1	0.8454604	0.5120399	1.1788809	3.670053	5.032467	0.0010269	0.0010269	-3.402033	—	—
220	47424238_st	0.8435727	0.4201082	1.2670372	1.544014	3.988953	0.0040532	0.0040532	-3.603289	—	—
63	TC6_mcf_hap5000213.hg.1	0.8408503	0.2330190	1.4486817	6.147923	5.134538	0.0009055	0.0009055	-3.386223	CFB	complement factor B
64	TC6_ssto_hap7000199.hg.1	0.8408503	-0.2060102	1.8877108	6.147923	5.134538	0.0009055	0.0009055	-3.386223	CFB	complement factor B
49	TC07002501.hg.1	0.8402226	0.1320519	1.5483933	6.241683	5.211356	0.0008245	0.0008245	-3.374713	CUX1	cut-like homeobox 1
265	2960249_st	0.8375813	0.4485498	1.2266129	4.028793	3.866076	0.0048148	0.0048148	-3.632514	—	—
173	TC10000401.hg.1	0.8372576	0.0295792	1.6449360	5.993515	4.193597	0.0030575	0.0030575	-3.557443	MYPN	myopalladin
71	TC6_dbb_hap3000222.hg.1	0.8369553	0.2573584	1.4165523	6.149681	5.099484	0.0009453	0.0009453	-3.391586	CFB	complement factor B
73	TC6_qbl_hap6000225.hg.1	0.8339594	0.4006764	1.2672423	6.150726	5.068983	0.0009815	0.0009815	-3.396308	CFB	complement factor B
134	TC09001890.hg.1	0.8286581	0.4801112	1.1772050	4.412597	4.440846	0.0021930	0.0021930	-3.506490	RPL36AP33	ribosomal protein L36a pseudogene 33
44	TC0X000188.hg.1	0.8283608	0.3352634	1.3214581	6.098042	5.314085	0.0007283	0.0007283	-3.359820	—	—
76	TC6_cox_hap2000245.hg.1	0.8270667	0.4580911	1.1960424	6.150349	5.037820	0.0010201	0.0010201	-3.401189	CFB	complement factor B
105	TC11001685.hg.1	0.8264321	0.4161904	1.2366737	4.293853	4.619888	0.0017337	0.0017337	-3.472414	—	—
164	TC01002849.hg.1	0.8233586	0.4151633	1.2315539	5.248295	4.230351	0.0029085	0.0029085	-3.549570	GBP4	guanylate binding protein 4
263	47419399_st	0.8209049	0.2705084	1.3713014	1.376656	3.867263	0.0048068	0.0048068	-3.632225	—	—
167	TC03002444.hg.1	0.8207990	0.1726418	1.4689562	2.599446	4.207501	0.0030002	0.0030002	-3.554452	—	—
67	TC06004077.hg.1	0.8182740	0.2788999	1.3576480	6.075330	5.120884	0.0009208	0.0009208	-3.388304	CFB	complement factor B
95	TC14000794.hg.1	0.8181480	0.4247866	1.2115095	7.508470	4.713652	0.0015358	0.0015358	-3.455456	TNFAIP2	tumor necrosis factor, alpha-induced protein 2
111	3615298_st	0.8118762	0.2975005	1.3262519	8.205502	4.572996	0.0018429	0.0018429	-3.481120	—	—
150	TC15002295.hg.1	0.8077203	0.2033557	1.4120848	3.828816	4.314295	0.0025967	0.0025967	-3.531985	—	—
177	TC11001672.hg.1	0.8063181	0.4692148	1.1434214	1.748819	4.175541	0.0031338	0.0031338	-3.561350	—	—
43	TC12002930.hg.1	0.8047076	0.3980462	1.2113689	4.019578	5.332844	0.0007121	0.0007121	-3.357161	—	—
104	TC10000258.hg.1	0.8031137	0.4485997	1.1576278	4.364083	4.624431	0.0017235	0.0017235	-3.471579	RNU6-1118P	RNA, U6 small nuclear 1118, pseudogene
127	TC21000560.hg.1	0.8009137	0.3532164	1.2486110	6.496864	4.489191	0.0020572	0.0020572	-3.497063	—	—
200	TC19001418.hg.1	0.7937023	0.3347152	1.2526895	1.892858	4.069221	0.0036263	0.0036263	-3.584894	—	—
84	TC0X000847.hg.1	0.7895641	0.2041832	1.3749450	4.458944	4.898520	0.0012139	0.0012139	-3.423709	—	—
160	TC10002067.hg.1	0.7818377	0.3613650	1.2023104	2.102672	4.250768	0.0028291	0.0028291	-3.545242	—	—
246	47419854_st	0.7808379	0.4498152	1.1118607	1.124662	3.906729	0.0045471	0.0045471	-3.622700	—	—
240	TC15001429.hg.1	0.7745617	0.3330076	1.2161159	3.473497	3.925781	0.0044272	0.0044272	-3.618150	—	—
90	TC03003286.hg.1	0.7691092	0.3010920	1.2371264	3.558113	4.755597	0.0014554	0.0014554	-3.448060	—	—
196	TC11001227.hg.1	0.7664856	0.1909620	1.3420092	4.331568	4.092022	0.0035140	0.0035140	-3.579766	RNU6-447P	RNA, U6 small nuclear 447, pseudogene
137	TC07002670.hg.1	0.7648118	0.3055055	1.2241181	5.753313	4.417598	0.0022618	0.0022618	-3.511084	—	—
99	TC22001203.hg.1	0.7646673	0.1424967	1.3868379	4.799403	4.678519	0.0016069	0.0016069	-3.461741	XXbac-B33L19.6	putative novel transcript
163	TC03002386.hg.1	0.7555364	0.2229028	1.2881701	2.306833	4.231385	0.0029044	0.0029044	-3.549350	—	—
92	TC18000524.hg.1	0.7550038	0.2351004	1.2749071	2.827281	4.746484	0.0014724	0.0014724	-3.449657	CCDC68	coiled-coil domain containing 68
79	3676041_st	0.7526350	0.3347408	1.1705292	9.118872	4.988422	0.0010847	0.0010847	-3.409042	—	—
254	3080337_st	0.7497764	0.3860874	1.1134654	6.783507	3.896104	0.0046155	0.0046155	-3.625251	—	—
129	TC07000874.hg.1	0.7482208	0.0131419	1.4832997	2.165423	4.479950	0.0020824	0.0020824	-3.498852	PP12708	—
204	PSR07002495.hg.1	0.7339653	0.2798991	1.1880315	6.810561	4.049060	0.0037287	0.0037287	-3.589463	—	—
66	TC6_mann_hap4000196.hg.1	0.7337230	0.3429212	1.1245249	6.184528	5.121146	0.0009205	0.0009205	-3.388264	CFB	complement factor B
244	TC11001374.hg.1	0.7335355	0.2893638	1.1777071	2.788817	3.917828	0.0044768	0.0044768	-3.620045	—	—
264	TC18000078.hg.1	0.7309407	-1.1873234	2.6492048	3.543635	3.866516	0.0048118	0.0048118	-3.632407	RNU6-316P	RNA, U6 small nuclear 316, pseudogene
231	PSR17008081.hg.1	0.7299395	0.1586448	1.3012341	6.158249	3.962078	0.0042080	0.0042080	-3.609569	—	—
174	TC04001615.hg.1	0.7280193	0.2194977	1.2365409	6.007871	4.190982	0.0030685	0.0030685	-3.558007	ZNF827	zinc finger protein 827
69	TC05002634.hg.1	0.7197046	0.2196629	1.2197462	6.672090	5.117982	0.0009241	0.0009241	-3.388747	JADE2	jade family PHD finger 2
133	TC06000242.hg.1	0.7184419	0.2886862	1.1481975	2.432489	4.449236	0.0021688	0.0021688	-3.504842	—	—
195	TC0X001792.hg.1	0.7107672	0.2257677	1.1957666	3.033972	4.092779	0.0035104	0.0035104	-3.579597	SYTL4	synaptotagmin-like 4
255	TC07000774.hg.1	0.7064419	0.2528995	1.1599844	6.007585	3.895015	0.0046226	0.0046226	-3.625513	—	—
256	TC08001586.hg.1	0.7064419	-0.1259415	1.5388254	6.007585	3.895015	0.0046226	0.0046226	-3.625513	—	—
130	TC02004646.hg.1	0.7062535	0.3281990	1.0843080	3.150427	4.479826	0.0020828	0.0020828	-3.498876	—	—
135	TC10002313.hg.1	0.7053321	0.2522385	1.1584257	3.479205	4.436471	0.0022058	0.0022058	-3.507351	RP11-328K15.1	putative novel transcript
248	TC15001153.hg.1	0.7011411	0.3641381	1.0381442	7.337381	3.902538	0.0045739	0.0045739	-3.623705	—	—
208	TC19000439.hg.1	0.6989013	0.1790683	1.2187344	6.944991	4.040804	0.0037716	0.0037716	-3.591344	KCTD15	potassium channel tetramerization domain containing 15
262	TC02002436.hg.1	0.6963666	0.3259581	1.0667750	4.458407	3.872414	0.0047720	0.0047720	-3.630974	AC012501.2	putative novel transcript
209	TC18000909.hg.1	0.6940239	-0.1357377	1.5237854	3.191854	4.036624	0.0037935	0.0037935	-3.592299	—	—
148	TC12002570.hg.1	0.6855918	-0.0387059	1.4098895	4.373392	4.350743	0.0024728	0.0024728	-3.524518	ADAM1A	ADAM metallopeptidase domain 1A, pseudogene
229	TC01004099.hg.1	0.6822668	0.2552193	1.1093142	3.386587	3.965504	0.0041879	0.0041879	-3.608765	RP11-34P13.9	putative novel transcript
232	TC10002623.hg.1	0.6815146	0.3348011	1.0282282	5.603294	3.960423	0.0042177	0.0042177	-3.609958	—	—
202	TC20000684.hg.1	0.6800001	0.1940307	1.1659694	4.208193	4.060574	0.0036698	0.0036698	-3.586849	RP5-1096J16.1	novel transcript
151	TC11001505.hg.1	0.6794497	0.2361287	1.1227707	2.771855	4.312484	0.0026030	0.0026030	-3.532358	MUC15	mucin 15, cell surface associated
118	TC08002024.hg.1	0.6765574	0.3389123	1.0142025	2.826270	4.542616	0.0019177	0.0019177	-3.486842	—	—
132	TC02000237.hg.1	0.6654975	-0.2619086	1.5929036	5.218370	4.466906	0.0021186	0.0021186	-3.501387	QPCT	glutaminyl-peptide cyclotransferase
191	3371074_st	0.6591336	0.3086497	1.0096174	7.627872	4.115090	0.0034043	0.0034043	-3.574623	—	—
199	TC14001955.hg.1	0.6553476	-0.5995144	1.9102095	4.031909	4.076040	0.0035923	0.0035923	-3.583356	—	—
171	TC03000021.hg.1	0.6525359	0.3249742	0.9800976	5.260091	4.196575	0.0030452	0.0030452	-3.556801	AC069277.2	novel transcript
161	TC04000122.hg.1	0.6489222	0.1583680	1.1394763	2.265269	4.246523	0.0028454	0.0028454	-3.546139	—	—
210	TC02002827.hg.1	0.6455148	0.2638350	1.0271947	5.917383	4.035407	0.0037999	0.0037999	-3.592577	DOCK10	dedicator of cytokinesis 10
212	TC09002641.hg.1	0.6434764	0.2744985	1.0124543	2.643924	4.025197	0.0038541	0.0038541	-3.594915	—	—
119	TC18000208.hg.1	0.6374043	0.3028061	0.9720026	6.400822	4.542128	0.0019189	0.0019189	-3.486934	ZNF532	zinc finger protein 532
251	3662477_st	0.6350424	0.0446590	1.2254257	6.701402	3.900144	0.0045893	0.0045893	-3.624280	—	—
143	TC05000494.hg.1	0.6240093	0.1757861	1.0722326	2.117060	4.371189	0.0024061	0.0024061	-3.520374	RP11-58B2.1	novel transcript
228	TC07003221.hg.1	0.6235236	0.1249971	1.1220500	2.428482	3.968432	0.0041708	0.0041708	-3.608079	AC006007.1	novel transcript
140	TC19001925.hg.1	0.6193665	0.0481092	1.1906239	4.586438	4.397079	0.0023244	0.0023244	-3.515172	—	—
162	3151626_st	0.6187273	0.2251933	1.0122614	8.261256	4.237552	0.0028802	0.0028802	-3.548039	—	—
203	TC16001503.hg.1	0.6187223	0.1305474	1.1068972	4.028525	4.051704	0.0037151	0.0037151	-3.588862	—	—
187	TC08001683.hg.1	0.6154342	-0.0318570	1.2627255	6.766000	4.137079	0.0033031	0.0033031	-3.569761	CASC7	cancer susceptibility candidate 7 (non-protein coding)
258	TC01005732.hg.1	0.6104743	0.1744978	1.0464507	6.220089	3.885342	0.0046859	0.0046859	-3.627845	CD58	CD58 molecule
217	TC11002583.hg.1	0.6101696	0.2551399	0.9651993	4.229620	4.008142	0.0039464	0.0039464	-3.598842	KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1
179	TC20001333.hg.1	0.6053640	0.1301695	1.0805586	6.140878	4.153654	0.0032289	0.0032289	-3.566122	—	—
238	PSR17016921.hg.1	0.5988230	0.1095231	1.0881230	8.418035	3.937346	0.0043560	0.0043560	-3.615404	—	—
237	TC06000886.hg.1	0.5899474	-0.2697944	1.4496892	6.465504	3.938735	0.0043476	0.0043476	-3.615075	GTF3C6	general transcription factor IIIC, polypeptide 6, alpha 35kDa
224	3670189_st	0.5886504	0.1801468	0.9971540	9.682810	3.980332	0.0041022	0.0041022	-3.605296	—	—
225	TC03003236.hg.1	0.5854098	0.1080063	1.0628133	2.295588	3.974163	0.0041376	0.0041376	-3.606737	—	—
205	TC07002886.hg.1	0.5824221	0.2555115	0.9093328	3.234605	4.045266	0.0037484	0.0037484	-3.590327	TBX20	T-box 20
197	TC04000102.hg.1	0.5686482	-0.1475547	1.2848510	4.446222	4.083656	0.0035548	0.0035548	-3.581643	USP17L23	ubiquitin specific peptidase 17-like family member 23
267	TC15001997.hg.1	-0.5373415	-1.1312311	0.0565482	2.426173	-3.846983	0.0049464	0.0049464	-3.637173	RNU6-322P	RNA, U6 small nuclear 322, pseudogene
261	TC22001312.hg.1	-0.5517385	-1.0291524	-0.0743246	2.145890	-3.879991	0.0047213	0.0047213	-3.629138	—	—
226	TC08000695.hg.1	-0.5538399	-1.1148365	0.0071567	8.788362	-3.968536	0.0041702	0.0041702	-3.608054	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)
266	TC09000899.hg.1	-0.5741384	-0.9687868	-0.1794899	5.532533	-3.849624	0.0049279	0.0049279	-3.636527	GLDC	glycine dehydrogenase (decarboxylating)
234	TC01005886.hg.1	-0.5872906	-1.2786413	0.1040602	4.309395	-3.953853	0.0042566	0.0042566	-3.611503	—	—
194	TC07002857.hg.1	-0.5906470	-1.2462029	0.0649090	1.555560	-4.101662	0.0034677	0.0034677	-3.577612	HOXA13	homeobox A13
156	TC11000630.hg.1	-0.5931577	-0.9861376	-0.2001779	6.050826	-4.265225	0.0027743	0.0027743	-3.542197	LOC101927789	putative ubiquitin-like protein FUBI-like protein ENSP00000310146-like
257	TC06001954.hg.1	-0.5937483	-1.6706809	0.4831843	2.236153	-3.891701	0.0046442	0.0046442	-3.626311	RNU4-70P	RNA, U4 small nuclear 70, pseudogene
215	TC01002750.hg.1	-0.5955574	-1.0089308	-0.1821839	2.515284	-4.010763	0.0039321	0.0039321	-3.598237	RNU4-88P	RNA, U4 small nuclear 88, pseudogene
221	TC12000800.hg.1	-0.6015607	-1.1455343	-0.0575871	1.546013	-3.983611	0.0040835	0.0040835	-3.604532	—	—
198	TC10001196.hg.1	-0.6040145	-0.9788659	-0.2291631	4.586791	-4.076294	0.0035910	0.0035910	-3.583299	LOC101929397	uncharacterized LOC101929397
242	TC12003243.hg.1	-0.6157111	-0.9677575	-0.2636647	5.963796	-3.920761	0.0044584	0.0044584	-3.619346	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
165	TC19001563.hg.1	-0.6341093	-0.9620810	-0.3061376	6.097101	-4.210165	0.0029894	0.0029894	-3.553880	ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide
206	TC15002232.hg.1	-0.6357077	-1.2202686	-0.0511469	4.218051	-4.044081	0.0037545	0.0037545	-3.590597	TLN2	talin 2
184	TC11001674.hg.1	-0.6408844	-1.0034116	-0.2783572	2.286587	-4.140237	0.0032888	0.0032888	-3.569066	—	—
235	TC05002340.hg.1	-0.6409260	-1.0259468	-0.2559051	2.113583	-3.943810	0.0043168	0.0043168	-3.613874	—	—
182	TC01000477.hg.1	-0.6418522	-1.1969982	-0.0867061	3.004895	-4.147173	0.0032577	0.0032577	-3.567542	—	—
239	TC03000405.hg.1	-0.6431977	-1.0137984	-0.2725971	3.058818	-3.936770	0.0043595	0.0043595	-3.615540	MAGI1-AS1	MAGI1 antisense RNA 1
233	TC09002054.hg.1	-0.6451089	-1.9331808	0.6429629	1.660053	-3.958926	0.0042265	0.0042265	-3.610310	—	—
166	TC17001951.hg.1	-0.6486904	-1.0706707	-0.2267101	3.544385	-4.208426	0.0029964	0.0029964	-3.554253	MIR3186	microRNA 3186
89	TC06001952.hg.1	-0.6747011	-1.3450474	-0.0043549	2.545895	-4.766417	0.0014354	0.0014354	-3.446171	EPHA7	EPH receptor A7
247	3475642_st	-0.6754552	-1.0560289	-0.2948815	10.375751	-3.903270	0.0045692	0.0045692	-3.623529	—	—
218	TC09001479.hg.1	-0.6777520	-1.0546664	-0.3008377	4.651295	-4.003312	0.0039730	0.0039730	-3.599958	RNY4P18	RNA, Ro-associated Y4 pseudogene 18
158	TC0X002210.hg.1	-0.6828448	-1.2462254	-0.1194641	2.116250	-4.259829	0.0027946	0.0027946	-3.543332	—	—
91	TC10000544.hg.1	-0.6883851	-1.0526021	-0.3241681	2.405286	-4.748258	0.0014691	0.0014691	-3.449346	—	—
136	TC05002022.hg.1	-0.6911415	-1.0738702	-0.3084129	1.704451	-4.427738	0.0022315	0.0022315	-3.509075	RNU6-168P	RNA, U6 small nuclear 168, pseudogene
153	TC02002817.hg.1	-0.6968342	-1.2125227	-0.1811456	1.920422	-4.306451	0.0026243	0.0026243	-3.533605	—	—
110	TC19000293.hg.1	-0.7105321	-1.2879307	-0.1331335	7.072137	-4.580395	0.0018252	0.0018252	-3.479736	—	—
149	TC0X002341.hg.1	-0.7212637	-1.4625807	0.0200534	4.009933	-4.334538	0.0025271	0.0025271	-3.527825	SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1
123	TC21000036.hg.1	-0.7259438	-1.4103475	-0.0415401	2.441798	-4.512972	0.0019938	0.0019938	-3.492488	RNU6-1326P	RNA, U6 small nuclear 1326, pseudogene
97	TC0X001317.hg.1	-0.7286902	-1.2869008	-0.1704797	1.930718	-4.707854	0.0015473	0.0015473	-3.456487	RP3-327A19.5	novel transcript, antisense to AKAP14
260	TC09000364.hg.1	-0.7412710	-1.4141221	-0.0684198	3.992747	-3.881222	0.0047132	0.0047132	-3.628840	—	—
180	TC15000904.hg.1	-0.7464206	-1.1173033	-0.3755379	5.980295	-4.151478	0.0032386	0.0032386	-3.566598	—	—
154	TC08001253.hg.1	-0.7487841	-1.4145386	-0.0830296	4.520402	-4.298766	0.0026516	0.0026516	-3.535196	CA8	carbonic anhydrase VIII
185	TC13001561.hg.1	-0.7573711	-1.1548839	-0.3598583	1.964871	-4.139264	0.0032932	0.0032932	-3.569280	—	—
37	TC19002526.hg.1	-0.7595084	-1.1194099	-0.3996068	5.273655	-5.451290	0.0006185	0.0006185	-3.340786	—	—
245	TC05000070.hg.1	-0.7623634	-3.3002385	1.7755117	2.969341	-3.913730	0.0045026	0.0045026	-3.621024	CTD-2199O4.1	novel transcript
169	47422398_st	-0.7705368	-1.1026447	-0.4384289	2.241157	-4.200823	0.0030276	0.0030276	-3.555886	—	—
96	TC09002683.hg.1	-0.7716138	-1.1856170	-0.3576105	2.081326	-4.711238	0.0015406	0.0015406	-3.455885	RP11-23B15.1	putative novel transcript
146	TC08001736.hg.1	-0.7726730	-1.3596289	-0.1857172	4.199063	-4.353095	0.0024650	0.0024650	-3.524040	EPPK1	epiplakin 1
94	TC10001334.hg.1	-0.7801463	-1.1474932	-0.4127995	7.703571	-4.738897	0.0014868	0.0014868	-3.450991	—	—
128	TC08000482.hg.1	-0.7805112	-1.2739676	-0.2870547	6.875943	-4.487473	0.0020619	0.0020619	-3.497395	RDH10	retinol dehydrogenase 10 (all-trans)
183	TC12001282.hg.1	-0.7853104	-1.2340536	-0.3365671	5.788827	-4.142051	0.0032806	0.0032806	-3.568667	EPS8	epidermal growth factor receptor pathway substrate 8
125	TC19000081.hg.1	-0.7858046	-1.3031525	-0.2684567	4.768912	-4.499106	0.0020305	0.0020305	-3.495151	CREB3L3	cAMP responsive element binding protein 3-like 3
106	TC08000694.hg.1	-0.7951082	-2.1562053	0.5659889	3.938238	-4.618289	0.0017373	0.0017373	-3.472708	COLEC10	collectin sub-family member 10 (C-type lectin)
243	TC08000324.hg.1	-0.7978501	-1.9119871	0.3162869	6.594341	-3.918700	0.0044713	0.0044713	-3.619837	AP3M2	adaptor-related protein complex 3, mu 2 subunit
107	TC12002835.hg.1	-0.7997320	-1.5304670	-0.0689970	4.241214	-4.611179	0.0017534	0.0017534	-3.474019	—	—
144	TC06003522.hg.1	-0.8051482	-1.4214348	-0.1888615	3.074953	-4.361646	0.0024369	0.0024369	-3.522304	—	—
250	TC18000564.hg.1	-0.8056253	-1.1816986	-0.4295520	5.081183	-3.900553	0.0045867	0.0045867	-3.624181	DSEL	dermatan sulfate epimerase-like
189	TC0X000727.hg.1	-0.8074459	-1.3808364	-0.2340553	4.709963	-4.135503	0.0033102	0.0033102	-3.570108	HMGB3	high mobility group box 3
80	47421299_st	-0.8124930	-1.1519265	-0.4730596	1.662695	-4.943964	0.0011466	0.0011466	-3.416234	—	—
223	TC0X002342.hg.1	-0.8298784	-1.2321109	-0.4276459	3.212648	-3.982243	0.0040912	0.0040912	-3.604851	SPANXC	SPANX family, member C
211	TC14001140.hg.1	-0.8369361	-1.7015248	0.0276526	5.741637	-4.031315	0.0038215	0.0038215	-3.593513	TXNDC16	thioredoxin domain containing 16
34	TC03000275.hg.1	-0.8445567	-1.1927725	-0.4963409	2.015274	-5.479850	0.0005981	0.0005981	-3.336942	MIR4443	microRNA 4443
214	47420513_st	-0.8474702	-1.4533521	-0.2415883	1.786096	-4.021389	0.0038745	0.0038745	-3.595790	—	—
141	47422093_st	-0.8493589	-1.4768467	-0.2218710	2.380390	-4.382030	0.0023715	0.0023715	-3.518189	—	—
114	TC03000892.hg.1	-0.8538817	-1.1829585	-0.5248048	5.787769	-4.555179	0.0018864	0.0018864	-3.484468	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1
121	TC03000482.hg.1	-0.8554361	-1.2262890	-0.4845832	2.572256	-4.524378	0.0019641	0.0019641	-3.490308	OR5AC2	olfactory receptor, family 5, subfamily AC, member 2
85	TC01001306.hg.1	-0.8629704	-1.3631826	-0.3627582	3.121130	-4.874537	0.0012512	0.0012512	-3.427705	SYT11	synaptotagmin XI
147	TC12001168.hg.1	-0.8777512	-1.6228490	-0.1326533	6.354506	-4.352140	0.0024681	0.0024681	-3.524234	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14
78	2909164_st	-0.8784470	-1.2157842	-0.5411098	6.678777	-5.023932	0.0010378	0.0010378	-3.403382	—	—
29	TC15000913.hg.1	-0.8923050	-1.2511359	-0.5334740	1.370365	-5.559276	0.0005449	0.0005449	-3.326462	—	—
222	TC03000768.hg.1	-0.8971410	-1.2527751	-0.5415068	6.515891	-3.983342	0.0040850	0.0040850	-3.604595	PLS1	plastin 1
100	TC14001401.hg.1	-0.9378662	-1.6662676	-0.2094647	1.643793	-4.659358	0.0016472	0.0016472	-3.465203	—	—
70	47423846_st	-0.9461408	-1.5004354	-0.3918462	1.295035	-5.116508	0.0009257	0.0009257	-3.388973	—	—
168	TC05002612.hg.1	-0.9497423	-1.3103802	-0.5891044	5.814343	-4.205138	0.0030099	0.0030099	-3.554959	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
241	47422090_st	-0.9570081	-1.7375830	-0.1764331	2.270161	-3.921016	0.0044568	0.0044568	-3.619285	—	—
201	47419787_st	-0.9611395	-1.3586029	-0.5636762	1.549715	-4.061800	0.0036636	0.0036636	-3.586572	—	—
82	TC13000234.hg.1	-0.9612145	-1.2819926	-0.6404364	3.523813	-4.928283	0.0011694	0.0011694	-3.418799	PCDH17	protocadherin 17
47	TC15001907.hg.1	-0.9649461	-1.4175256	-0.5123666	2.345389	-5.240144	0.0007962	0.0007962	-3.370483	—	—
252	47423307_st	-0.9767491	-1.4146055	-0.5388928	1.589235	-3.898999	0.0045967	0.0045967	-3.624555	—	—
175	TC12002552.hg.1	-0.9799902	-1.9791565	0.0191762	5.767873	-4.184455	0.0030959	0.0030959	-3.559418	—	—
25	TC01005828.hg.1	-0.9809281	-1.6357572	-0.3260989	5.949490	-5.754576	0.0004349	0.0004349	-3.301938	FLG	filaggrin
46	TC19000805.hg.1	-0.9812271	-1.4635478	-0.4989064	6.274601	-5.270295	0.0007677	0.0007677	-3.366100	ERVV-2	endogenous retrovirus group V, member 2
188	TC06000429.hg.1	-0.9944716	-1.9539492	-0.0349940	4.178663	-4.136041	0.0033078	0.0033078	-3.569989	—	—
112	TC10000522.hg.1	-1.0096445	-1.4379022	-0.5813867	4.322070	-4.562917	0.0018674	0.0018674	-3.483011	—	—
19	TC02000927.hg.1	-1.0099038	-2.0102490	-0.0095586	4.825662	-6.057611	0.0003096	0.0003096	-3.267131	KIF5C	kinesin family member 5C
30	TC0X000948.hg.1	-1.0170142	-1.5227454	-0.5112829	5.112170	-5.540506	0.0005570	0.0005570	-3.328911	TMEM47	transmembrane protein 47
22	TC06002112.hg.1	-1.0286686	-2.0205289	-0.0368083	6.964645	-5.889046	0.0003735	0.0003735	-3.286027	CTGF	connective tissue growth factor
40	TC13000634.hg.1	-1.0430193	-1.4672095	-0.6188291	5.447627	-5.371703	0.0006798	0.0006798	-3.351710	SLC25A30	solute carrier family 25, member 30
170	TC08001816.hg.1	-1.0431233	-1.7414280	-0.3448187	6.020214	-4.199102	0.0030347	0.0030347	-3.556257	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
126	TC15000512.hg.1	-1.0480840	-1.4515697	-0.6445982	3.722066	-4.489440	0.0020565	0.0020565	-3.497015	—	—
268	TC10002574.hg.1	-1.0625140	-1.3988333	-0.7261946	4.520920	-3.846481	0.0049499	0.0049499	-3.637296	LOC101929397	uncharacterized LOC101929397
65	TC01005829.hg.1	-1.0676755	-1.7102247	-0.4251264	5.425159	-5.133651	0.0009065	0.0009065	-3.386358	FLG	filaggrin
102	47419283_st	-1.0728938	-1.4714313	-0.6743562	1.969319	-4.630072	0.0017109	0.0017109	-3.470543	—	—
75	TC01003245.hg.1	-1.0760953	-1.4857672	-0.6664235	5.883388	-5.049497	0.0010054	0.0010054	-3.399354	FLG	filaggrin
14	TC02002628.hg.1	-1.0842553	-1.6669859	-0.5015246	3.832753	-7.060002	0.0001088	0.0001088	-3.174979	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
26	47421979_st	-1.0945896	-1.5000075	-0.6891718	3.526882	-5.679526	0.0004740	0.0004740	-3.311158	—	—
18	TC08001440.hg.1	-1.0959806	-1.7345945	-0.4573668	4.787639	-6.190944	0.0002676	0.0002676	-3.252962	TP53INP1	tumor protein p53 inducible nuclear protein 1
16	TC02002499.hg.1	-1.1160429	-1.7561554	-0.4759304	3.027889	-6.561174	0.0001805	0.0001805	-3.216901	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit
120	TC04001997.hg.1	-1.1431700	-1.4817559	-0.8045841	2.702580	-4.531446	0.0019460	0.0019460	-3.488962	—	—
207	TC09001352.hg.1	-1.1773506	-1.6591937	-0.6955074	1.635598	-4.041638	0.0037672	0.0037672	-3.591154	—	—
259	TC02003749.hg.1	-1.1880571	-1.5158824	-0.8602318	3.811939	-3.884024	0.0046946	0.0046946	-3.628163	—	—
35	TC12001170.hg.1	-1.2109123	-2.8390974	0.4172728	9.257128	-5.460716	0.0006117	0.0006117	-3.339513	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
33	TC12001907.hg.1	-1.2111991	-1.6431281	-0.7792701	6.131961	-5.486883	0.0005931	0.0005931	-3.336002	—	—
172	TC06000434.hg.1	-1.2148922	-1.8603118	-0.5694725	3.119678	-4.194146	0.0030553	0.0030553	-3.557324	—	—
227	TC04000117.hg.1	-1.2284320	-1.7578579	-0.6990061	3.123046	-3.968485	0.0041705	0.0041705	-3.608066	—	—
50	TC19001622.hg.1	-1.2429091	-1.5664296	-0.9193886	6.488263	-5.177160	0.0008595	0.0008595	-3.379797	—	—
74	47424436_st	-1.2807591	-1.8399708	-0.7215473	1.851769	-5.049985	0.0010048	0.0010048	-3.399277	—	—
93	TC20000876.hg.1	-1.2955753	-1.8234820	-0.7676686	8.177874	-4.740065	0.0014846	0.0014846	-3.450785	SLPI	secretory leukocyte peptidase inhibitor
159	TC6_cox_hap2000100.hg.1	-1.3044060	-1.7172863	-0.8915256	2.665726	-4.252875	0.0028211	0.0028211	-3.544797	HCG24	HLA complex group 24
68	TC12002734.hg.1	-1.3161750	-2.1399112	-0.4924387	10.329069	-5.119041	0.0009229	0.0009229	-3.388586	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
138	47419884_st	-1.3962335	-1.7275910	-1.0648761	1.860523	-4.404372	0.0023019	0.0023019	-3.513715	—	—
12	TC15001895.hg.1	-1.3963063	-1.7880622	-1.0045504	1.433147	-7.284620	0.0000874	0.0000874	-3.158253	—	—
36	TC02001238.hg.1	-1.4117604	-1.8711880	-0.9523328	4.390431	-5.451950	0.0006181	0.0006181	-3.340696	MAP2	microtubule-associated protein 2
157	TC22000577.hg.1	-1.4718483	-1.8320855	-1.1116111	2.949695	-4.262416	0.0027849	0.0027849	-3.542788	—	—
131	TC08001062.hg.1	-1.4966222	-2.2729488	-0.7202955	5.932169	-4.475130	0.0020957	0.0020957	-3.499787	STC1	stanniocalcin 1
113	TC16000269.hg.1	-1.5074228	-2.0358776	-0.9789680	3.413260	-4.559366	0.0018761	0.0018761	-3.483679	—	—
20	47424018_st	-1.5773243	-2.4409392	-0.7137093	2.689304	-5.974953	0.0003393	0.0003393	-3.276256	—	—
124	PSR06024774.hg.1	-1.6480842	-2.0410917	-1.2550767	3.486136	-4.508144	0.0020065	0.0020065	-3.493414	—	—
38	47424232_st	-1.8411164	-2.3463548	-1.3358780	1.776524	-5.445155	0.0006230	0.0006230	-3.341617	—	—
48	TC01005830.hg.1	-2.0246084	-2.5432793	-1.5059375	4.657497	-5.219109	0.0008168	0.0008168	-3.373569	FLG	filaggrin
10	3597981_st	-3.6560418	-4.0693860	-3.2426976	1.951490	-7.830909	0.0000524	0.0000524	-3.122281	—	—

2. GFR-specific treatment responses: GO enrichment analysis

Gather a set of background genes to compare

library(genefilter)
library(Biobase)
#make a list of diff genes
diff.probe <- subset(x = diff.tGFR)$probe
background.genes <- genefilter::genefinder(eset, as.character(diff.probe), method = "manhattan", scale = "none")
background.genes <- sapply(background.genes, function(x) x$indices)
background.genes <- as.vector(background.genes)
back.genes <- featureNames(project.bgcorrect.norm.avg)[background.genes]

Remove any differentially expressed genes from the background gene set and verify that it is correct: the diff set and the background set should have nothing in common.

back.genes <- setdiff(back.genes, diff.probe)
intersect(back.genes, diff.probe)

## character(0)

Examine mean intensity of the diff set, background set and all probes

library(cancerTiming)
fit.all <- topTable(fit, number = nrow(fit))
multidensity(list(
    all = fit.all[,"AveExpr"],
    fore = diff.tGFR[,"AveExpr"],  
    back = fit.all[rownames(fit.all) %in% back.genes, "AveExpr"]),
  col = c("#e46981", "#ae7ee2", "#a7ad4a"),
  xlab = "mean expression",
  main = "GFR vs GF: Differentially Expressed, Background, and All gene expression levels"
)

GFR-specific treatment responses: GO pathway enrichment analysis

Is the differential expression set enriched in particular functional categories? This is why we have created a background gene set, so that we know the “typical” functional distribution of genes expressed at similar levels. We will connect the probe names to GO categories and run a few tests for pathway enrichment.

library(topGO)

gene.IDs <- rownames(eset)
in.universe <- gene.IDs %in% c(diff.probe,back.genes)
in.selection <- gene.IDs %in% diff.probe

all.genes <- in.selection[in.universe]
all.genes <- factor(as.integer(in.selection[in.universe]))
names(all.genes) <- gene.IDs[in.universe]

#this builds a database with all GO information related to our two test sets AND whether the gene is differentially expressed
top_GO_data <- new("topGOdata", ontology = "BP", allGenes = all.genes,
 nodeSize = 10, annot = annFUN.db, affyLib = "hta20transcriptcluster.db")

result_top_GO_elim <- 
  runTest(top_GO_data, algorithm = "elim", statistic = "Fisher")
result_top_GO_classic <- 
  runTest(top_GO_data, algorithm = "classic", statistic = "Fisher")

library(stringr)
res_top_GO <- GenTable(top_GO_data, Fisher.elim = result_top_GO_elim,
        Fisher.classic = result_top_GO_classic,
        orderBy = "Fisher.elim" , topNodes = 100)

genes_top_GO <- printGenes(top_GO_data, whichTerms = res_top_GO$GO.ID,
    chip = "hta20transcriptcluster.db", geneCutOff = 1000)

res_top_GO$sig_genes <- sapply(genes_top_GO, function(x){
                str_c(paste0(x[x$'raw p-value' == 2, "Symbol.id"],";"), 
                      collapse = "")
    })

res_top_GO <- res_top_GO[order(-res_top_GO$Significant / res_top_GO$Expected),]
kable(res_top_GO) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	GO.ID	Term	Annotated	Significant	Expected	Rank in Fisher.classic	Fisher.elim	Fisher.classic	sig_genes
53	GO:0006956	complement activation	11	8	0.61	2	0.05113	9.2e-09	CFB;COLEC10;CFB;CFB;CFB;CFB;CFB;CFB;
1	GO:0030449	regulation of complement activation	10	7	0.55	7	1.3e-07	1.3e-07	CFB;CFB;CFB;CFB;CFB;CFB;CFB;
93	GO:0072376	protein activation cascade	12	8	0.66	4	0.09968	2.6e-08	CFB;COLEC10;CFB;CFB;CFB;CFB;CFB;CFB;
2	GO:0019886	antigen processing and presentation of e…	13	7	0.72	18	1.6e-06	1.6e-06	HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
10	GO:0071346	cellular response to interferon-gamma	23	10	1.27	5	0.00392	1.0e-07	GBP4;CD58;CCL20;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
3	GO:0060333	interferon-gamma-mediated signaling path…	16	7	0.89	25	9.5e-06	9.5e-06	HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
16	GO:0006959	humoral immune response	29	11	1.61	6	0.01362	1.2e-07	CXCL8;CXCL5;CFB;COLEC10;SLPI;CFB;CFB;CFB;CFB;CFB;CFB;
7	GO:1990869	cellular response to chemokine	12	4	0.66	48	0.00309	0.00309	CCL20;CXCL8;CXCL5;SLC12A2;
8	GO:0031424	keratinization	12	4	0.66	49	0.00309	0.00309	FLG;FLG;FLG;FLG;
4	GO:0050852	T cell receptor signaling pathway	27	7	1.50	36	0.00045	0.00045	HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
24	GO:0007156	homophilic cell adhesion via plasma memb…	12	3	0.66	72	0.02510	0.02510	CDH10;MYPN;PCDH17;
9	GO:0097479	synaptic vesicle localization	20	5	1.11	51	0.00372	0.00372	SYT11;KIF5C;MAP2;AP3M2;PCDH17;
14	GO:0051494	negative regulation of cytoskeleton orga…	17	4	0.94	59	0.01200	0.01200	MAP2;TMEFF2;NAV3;EPS8;
15	GO:1902904	negative regulation of supramolecular fi…	17	4	0.94	60	0.01200	0.01200	MAP2;TMEFF2;NAV3;EPS8;
30	GO:0035725	sodium ion transmembrane transport	13	3	0.72	82	0.03135	0.03135	SCN9A;SLC12A2;ATP1A3;
31	GO:0019730	antimicrobial humoral response	13	3	0.72	83	0.03135	0.03135	CXCL8;CXCL5;SLPI;
17	GO:0048489	synaptic vesicle transport	18	4	1.00	62	0.01478	0.01478	SYT11;KIF5C;MAP2;AP3M2;
18	GO:0097480	establishment of synaptic vesicle locali…	18	4	1.00	63	0.01478	0.01478	SYT11;KIF5C;MAP2;AP3M2;
5	GO:0045087	innate immune response	98	21	5.43	3	0.00079	1.6e-08	GBP4;CD58;CCL20;HLA-DRA;CFB;COLEC10;HMGB3;MUC15;SLPI;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;
42	GO:0098739	import across plasma membrane	14	3	0.78	95	0.03834	0.03834	SLC12A2;SLC7A2;ATP1A3;
43	GO:0030593	neutrophil chemotaxis	14	3	0.78	96	0.03834	0.03834	CCL20;CXCL8;CXCL5;
23	GO:0008643	carbohydrate transport	19	4	1.05	69	0.01795	0.01795	PLS1;SLC2A14;SLC2A3;SLC2A3;
95	GO:0072678	T cell migration	10	2	0.55	154	0.10224	0.10224	CCL20;SLC12A2;
96	GO:0032272	negative regulation of protein polymeriz…	10	2	0.55	155	0.10224	0.10224	MAP2;EPS8;
97	GO:1901879	regulation of protein depolymerization	10	2	0.55	156	0.10224	0.10224	NAV3;EPS8;
98	GO:0006767	water-soluble vitamin metabolic process	10	2	0.55	157	0.10224	0.10224	SLC2A3;SLC2A3;
99	GO:1990823	response to leukemia inhibitory factor	10	2	0.55	158	0.10224	0.10224	GLDC;EPS8;
100	GO:1990830	cellular response to leukemia inhibitory…	10	2	0.55	159	0.10224	0.10224	GLDC;EPS8;
48	GO:0010970	transport along microtubule	15	3	0.83	105	0.04605	0.04605	KIF5C;MAP2;AP3M2;
49	GO:0071621	granulocyte chemotaxis	15	3	0.83	106	0.04605	0.04605	CCL20;CXCL8;CXCL5;
50	GO:0099111	microtubule-based transport	15	3	0.83	107	0.04605	0.04605	KIF5C;MAP2;AP3M2;
6	GO:0050890	cognition	35	7	1.94	45	0.00236	0.00236	HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
11	GO:0042119	neutrophil activation	32	6	1.77	53	0.00685	0.00685	CD58;QPCT;CXCL8;SLC2A3;SLC2A3;SLPI;
54	GO:1990266	neutrophil migration	16	3	0.89	110	0.05447	0.05447	CCL20;CXCL8;CXCL5;
51	GO:0006954	inflammatory response	76	14	4.21	29	0.04726	3.7e-05	CCL20;SCN9A;CXCL8;CXCL5;CFB;SLC7A2;SAA4;CREB3L3;CFB;CFB;CFB;CFB;CFB;CFB;
61	GO:0015893	drug transport	17	3	0.94	118	0.06357	0.06357	SYT11;SLC7A2;SLC25A30;
62	GO:0006814	sodium ion transport	17	3	0.94	119	0.06357	0.06357	SCN9A;SLC12A2;ATP1A3;
63	GO:0030705	cytoskeleton-dependent intracellular tra…	17	3	0.94	120	0.06357	0.06357	KIF5C;MAP2;AP3M2;
21	GO:0006952	defense response	159	28	8.81	1	0.01591	3.8e-09	SYT11;GBP4;CD58;CCL20;SCN9A;CXCL8;CXCL5;HLA-DRA;CFB;COLEC10;SLC7A2;HMGB3;MUC15;SAA4;CREB3L3;SLPI;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;HLA-DRA;CFB;
35	GO:0051017	actin filament bundle assembly	23	4	1.27	88	0.03464	0.03464	TMEFF2;PLS1;CTGF;EPS8;
36	GO:0061572	actin filament bundle organization	23	4	1.27	89	0.03464	0.03464	TMEFF2;PLS1;CTGF;EPS8;
69	GO:0042742	defense response to bacterium	18	3	1.00	127	0.07332	0.07332	SYT11;CCL20;SLPI;
70	GO:0071774	response to fibroblast growth factor	18	3	1.00	128	0.07332	0.07332	CXCL8;CTGF;KCNC1;
71	GO:0015749	monosaccharide transmembrane transport	18	3	1.00	129	0.07332	0.07332	SLC2A14;SLC2A3;SLC2A3;
72	GO:0071804	cellular potassium ion transport	18	3	1.00	130	0.07332	0.07332	SLC12A2;KCNC1;ATP1A3;
73	GO:0071805	potassium ion transmembrane transport	18	3	1.00	131	0.07332	0.07332	SLC12A2;KCNC1;ATP1A3;
74	GO:1904659	glucose transmembrane transport	18	3	1.00	132	0.07332	0.07332	SLC2A14;SLC2A3;SLC2A3;
75	GO:0008645	hexose transmembrane transport	18	3	1.00	133	0.07332	0.07332	SLC2A14;SLC2A3;SLC2A3;
76	GO:0097530	granulocyte migration	18	3	1.00	134	0.07332	0.07332	CCL20;CXCL8;CXCL5;
77	GO:0019722	calcium-mediated signaling	18	3	1.00	135	0.07332	0.07332	CCL20;CXCL8;ERBB3;
78	GO:0034219	carbohydrate transmembrane transport	18	3	1.00	136	0.07332	0.07332	SLC2A14;SLC2A3;SLC2A3;
25	GO:0002283	neutrophil activation involved in immune…	31	5	1.72	73	0.02517	0.02517	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
26	GO:0043312	neutrophil degranulation	31	5	1.72	74	0.02517	0.02517	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
28	GO:0002446	neutrophil mediated immunity	32	5	1.77	76	0.02856	0.02856	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
89	GO:0031333	negative regulation of protein complex a…	20	3	1.11	147	0.09468	0.09468	MAP2;TBX20;EPS8;
90	GO:0050918	positive chemotaxis	20	3	1.11	148	0.09468	0.09468	CXCL8;COLEC10;SAA4;
91	GO:0006813	potassium ion transport	20	3	1.11	149	0.09468	0.09468	SLC12A2;KCNC1;ATP1A3;
92	GO:0098742	cell-cell adhesion via plasma-membrane a…	20	3	1.11	150	0.09468	0.09468	CDH10;MYPN;PCDH17;
56	GO:0070374	positive regulation of ERK1 and ERK2 cas…	27	4	1.50	113	0.05806	0.05806	CCL20;EPHA7;CTGF;ERBB3;
57	GO:0030595	leukocyte chemotaxis	27	4	1.50	114	0.05806	0.05806	CCL20;CXCL8;CXCL5;SLC12A2;
39	GO:0043299	leukocyte degranulation	34	5	1.88	92	0.03619	0.03619	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
40	GO:0002275	myeloid cell activation involved in immu…	34	5	1.88	93	0.03619	0.03619	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
46	GO:0002444	myeloid leukocyte mediated immunity	36	5	1.99	101	0.04497	0.04497	CD58;QPCT;SLC2A3;SLC2A3;SLPI;
47	GO:0030336	negative regulation of cell migration	36	5	1.99	102	0.04497	0.04497	TMEFF2;STC1;TP53INP1;EPPK1;NAV3;
67	GO:0051650	establishment of vesicle localization	29	4	1.61	124	0.07230	0.07230	SYT11;KIF5C;MAP2;AP3M2;
68	GO:0099003	vesicle-mediated transport in synapse	29	4	1.61	125	0.07230	0.07230	SYT11;KIF5C;MAP2;AP3M2;
52	GO:2000146	negative regulation of cell motility	37	5	2.05	109	0.04980	0.04980	TMEFF2;STC1;TP53INP1;EPPK1;NAV3;
12	GO:0016032	viral process	67	9	3.71	57	0.00967	0.00967	CXCL8;HLA-DRA;SLPI;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
41	GO:0002366	leukocyte activation involved in immune …	46	6	2.55	94	0.03800	0.03800	CD58;QPCT;DOCK10;SLC2A3;SLC2A3;SLPI;
87	GO:0010639	negative regulation of organelle organiz…	31	4	1.72	145	0.08816	0.08816	MAP2;TMEFF2;NAV3;EPS8;
60	GO:0048638	regulation of developmental growth	39	5	2.16	117	0.06035	0.06035	MAP2;PLS1;EPHA7;TBX20;EPPK1;
45	GO:0002263	cell activation involved in immune respo…	47	6	2.60	98	0.04168	0.04168	CD58;QPCT;DOCK10;SLC2A3;SLC2A3;SLPI;
29	GO:0006820	anion transport	55	7	3.05	78	0.02893	0.02893	SLC12A2;STC1;SLC7A2;SLC2A3;SLC2A3;SLC25A30;SLC16A6;
34	GO:0045055	regulated exocytosis	57	7	3.16	87	0.03446	0.03446	SYT11;CD58;QPCT;SYTL4;SLC2A3;SLC2A3;SLPI;
66	GO:1902903	regulation of supramolecular fiber organ…	41	5	2.27	123	0.07209	0.07209	MAP2;TMEFF2;CTGF;NAV3;EPS8;
27	GO:0097435	supramolecular fiber organization	66	8	3.66	75	0.02606	0.02606	MAP2;TMEFF2;PLS1;CTGF;EPPK1;MYPN;NAV3;EPS8;
81	GO:0060326	cell chemotaxis	42	5	2.33	139	0.07840	0.07840	CCL20;CXCL8;CXCL5;SLC12A2;SAA4;
82	GO:0015711	organic anion transport	42	5	2.33	140	0.07840	0.07840	SLC7A2;SLC2A3;SLC2A3;SLC25A30;SLC16A6;
83	GO:0051271	negative regulation of cellular componen…	42	5	2.33	141	0.07840	0.07840	TMEFF2;STC1;TP53INP1;EPPK1;NAV3;
84	GO:0032535	regulation of cellular component size	42	5	2.33	142	0.07840	0.07840	MAP2;PLS1;SLC12A2;EPHA7;EPS8;
58	GO:0050900	leukocyte migration	51	6	2.83	115	0.05863	0.05863	CD58;CCL20;CXCL8;CXCL5;SLC12A2;EPS8;
86	GO:0040013	negative regulation of locomotion	43	5	2.38	144	0.08500	0.08500	TMEFF2;STC1;TP53INP1;EPPK1;NAV3;
32	GO:0006887	exocytosis	69	8	3.82	85	0.03312	0.03312	SYT11;CD58;QPCT;SYTL4;SLC2A3;SLC2A3;TNFAIP2;SLPI;
22	GO:0034622	cellular protein-containing complex asse…	98	11	5.43	66	0.01637	0.01637	MAP2;HLA-DRA;TBX20;NAV3;EPS8;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
55	GO:0051129	negative regulation of cellular componen…	63	7	3.49	112	0.05515	0.05515	SYT11;MAP2;TMEFF2;EPHA7;TBX20;NAV3;EPS8;
59	GO:0048589	developmental growth	64	7	3.55	116	0.05923	0.05923	MAP2;PLS1;EPHA7;TBX20;RDH10;STC1;EPPK1;
37	GO:0042330	taxis	83	9	4.60	90	0.03579	0.03579	KIF5C;CCL20;CXCL8;CXCL5;SLC12A2;EPHA7;COLEC10;MYPN;SAA4;
38	GO:0006935	chemotaxis	83	9	4.60	91	0.03579	0.03579	KIF5C;CCL20;CXCL8;CXCL5;SLC12A2;EPHA7;COLEC10;MYPN;SAA4;
13	GO:0040011	locomotion	217	20	12.02	58	0.01152	0.01152	CD58;KIF5C;CCL20;TMEFF2;DOCK10;CXCL8;CXCL5;SLC12A2;EPHA7;CTGF;TBX20;COLEC10;STC1;TP53INP1;EPPK1;MYPN;SAA4;NAV3;EPS8;ERBB3;
44	GO:0016192	vesicle-mediated transport	154	14	8.53	97	0.03879	0.03879	SYT11;CD58;QPCT;KIF5C;MAP2;CXCL8;CUX1;AP3M2;MAL2;SYTL4;SLC2A3;SLC2A3;TNFAIP2;SLPI;
19	GO:0006928	movement of cell or subcellular componen…	237	21	13.13	64	0.01483	0.01483	CD58;KIF5C;MAP2;CCL20;TMEFF2;DOCK10;CXCL8;CXCL5;SLC12A2;EPHA7;CTGF;TBX20;AP3M2;STC1;TP53INP1;EPPK1;MYPN;SAA4;NAV3;EPS8;ERBB3;
79	GO:0006811	ion transport	139	12	7.70	137	0.07559	0.07559	SYT11;SCN9A;SLC12A2;CTGF;STC1;SLC7A2;KCNC1;SLC2A3;SLC2A3;SLC25A30;SLC16A6;ATP1A3;
94	GO:0051270	regulation of cellular component movemen…	116	10	6.43	153	0.10168	0.10168	MAP2;CCL20;TMEFF2;DOCK10;CXCL8;STC1;TP53INP1;EPPK1;NAV3;ERBB3;
20	GO:0022607	cellular component assembly	283	24	15.68	65	0.01515	0.01515	SYT11;MAP2;TMEFF2;PLS1;CDH10;HLA-DRA;EPHA7;CTGF;TBX20;TP53INP1;EPPK1;MYPN;KCNC1;NAV3;EPS8;PCDH17;TLN2;KCTD15;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
85	GO:0065003	protein-containing complex assembly	172	14	9.53	143	0.08463	0.08463	SYT11;MAP2;HLA-DRA;TBX20;KCNC1;NAV3;EPS8;KCTD15;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
64	GO:0051674	localization of cell	197	16	10.92	121	0.06790	0.06790	CD58;CCL20;TMEFF2;DOCK10;CXCL8;CXCL5;SLC12A2;CTGF;TBX20;STC1;TP53INP1;EPPK1;SAA4;NAV3;EPS8;ERBB3;
65	GO:0048870	cell motility	197	16	10.92	122	0.06790	0.06790	CD58;CCL20;TMEFF2;DOCK10;CXCL8;CXCL5;SLC12A2;CTGF;TBX20;STC1;TP53INP1;EPPK1;SAA4;NAV3;EPS8;ERBB3;
80	GO:0016477	cell migration	185	15	10.25	138	0.07729	0.07729	CD58;CCL20;TMEFF2;DOCK10;CXCL8;CXCL5;SLC12A2;CTGF;TBX20;STC1;TP53INP1;EPPK1;SAA4;NAV3;EPS8;
33	GO:0044085	cellular component biogenesis	303	24	16.79	86	0.03348	0.03348	SYT11;MAP2;TMEFF2;PLS1;CDH10;HLA-DRA;EPHA7;CTGF;TBX20;TP53INP1;EPPK1;MYPN;KCNC1;NAV3;EPS8;PCDH17;TLN2;KCTD15;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;HLA-DRA;
88	GO:0051179	localization	549	39	30.42	81	0.09037	0.03087	SYT11;CD58;QPCT;KIF5C;MAP2;CCL20;SCN9A;TMEFF2;DOCK10;PLS1;CXCL8;CXCL5;SLC12A2;CTGF;CUX1;TBX20;AP3M2;MAL2;STC1;TP53INP1;EPPK1;SLC7A2;SYTL4;KCNC1;SAA4;NAV3;SLC2A14;SLC2A3;EPS8;SLC2A3;ERBB3;PCDH17;SLC25A30;TNFAIP2;TLN2;SLC16A6;CCDC68;ATP1A3;SLPI;

write.csv(res_top_GO, "nested_interactions/tGFR.specific.GO.pathway.enrichment.csv")

This is a ranking of which GO terms are enriched according to two different testing strategies, elim and Fisher.classic. these are, roughly, probability scores and can be broadly interpreted the same way as p-scores.

GFR-specific treatment responses: Visualizing the GO results:

nodes <- showSigOfNodes(top_GO_data, score(result_top_GO_elim), firstSigNodes = 3,
               useInfo = 'def')

png("nested_interactions/tGFR.specific.GO.pathway.enrichment.nodes.png")
nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 77 
## Number of Edges = 145 
## 
## $complete.dag
## [1] "A graph with 77 nodes."

dev.off()

## png 
##   2

nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 77 
## Number of Edges = 145 
## 
## $complete.dag
## [1] "A graph with 77 nodes."

3. GFR-specific treatment responses: Pathway enrichment analysis via Reactome

map DE genes to Entrez, then reactome pathways, and perform pathway enrichment:

library(reactome.db)
library(DOSE)
library(ReactomePA)
entrez_ids <- mapIds(hta20transcriptcluster.db, 
      keys = rownames(eset), 
      keytype = "PROBEID",
      column = "ENTREZID",
      multiVals = "first")

reactome_enrich <- enrichPathway(gene = entrez_ids[diff.probe], 
                                universe = entrez_ids[c(diff.probe, 
                                                        back.genes)],
                                organism = "human",
                                pvalueCutoff = 0.05, pAdjustMethod = "none",
                                qvalueCutoff = 1, 
                                readable = TRUE)

reactome_enrich@result$Description <- paste0(str_sub(
                                    reactome_enrich@result$Description, 1, 20),
                                    "...")

write.csv(as.data.frame(reactome_enrich), "nested_interactions/tGFR.specific.reactome.pathway.enrichment.png")

kable(reactome_enrich) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
R-HSA-425407	R-HSA-425407	SLC-mediated transme…	4/37	17/820	0.0054874	0.0054874	0.3985617	SLC2A3/SLC2A14/SLC12A2/SLC7A2	4
R-HSA-382551	R-HSA-382551	Transport of small m…	6/37	46/820	0.0138254	0.0138254	0.4805145	SLC2A3/CREB3L3/SLC2A14/ATP1A3/SLC12A2/SLC7A2	6
R-HSA-6798695	R-HSA-6798695	Neutrophil degranula…	4/37	26/820	0.0257052	0.0257052	0.4805145	SLC2A3/SLPI/QPCT/CD58	4
R-HSA-375276	R-HSA-375276	Peptide ligand-bindi…	3/37	15/820	0.0264631	0.0264631	0.4805145	CXCL5/CXCL8/CCL20	3
R-HSA-418594	R-HSA-418594	G alpha (i) signalli…	4/37	30/820	0.0413854	0.0413854	0.5234376	RDH10/CXCL5/CXCL8/CCL20	4

GFR-specific treatment responses: Visualizing reactome results

Barplots, showing reaction categories represented and their respective p-values:

png("nested_interactions/tGFR.specific.reactome.pathway.enrichment.barplot.png")
barplot(reactome_enrich)
dev.off()

## png 
##   2

barplot(reactome_enrich)

png("nested_interactions/tGFR.specific.reactome.pathway.enrichment.emapplot.png")
emapplot(reactome_enrich, showCategory = 20)
dev.off()

## png 
##   2

emapplot(reactome_enrich, showCategory = 20)

In this plot, color is p-value, size is proportional to the number of DE genes that mapped to the pathway, and the edge thickness is proportional to the number of shared genes between the units. This is useful for examining the interdependence of the pathways; which results should be taken more serioiusly, are independent? This particular plot shows the top ten most significant pathways, regardless of their p-values

C. Generalized treatment responses

1. Generalized treatment responses: Run “fit” algorithms and separate out the significantly different probes using a contrast set

eset <- project.bgcorrect.norm.avg.filt
fit <- lmFit(eset, design1)
fit <- eBayes(fit, trend=T, robust=T)
diff.t <- topTable(fit, coef=3,p.value = 0.05,  n = Inf )
setDT(diff.t, keep.rownames = TRUE)[]

##                            rn      logFC  AveExpr          t      P.Value
##   1:              47424360_st -3.4461924 2.704951 -17.599202 7.685340e-08
##   2:          TC08002280.hg.1  2.1207662 3.957387  15.477227 1.253966e-07
##   3:          TC11003279.hg.1  2.2131365 4.818089  15.428364 1.287790e-07
##   4:          TC06001902.hg.1  1.9881291 5.259243  15.295015 1.385370e-07
##   5:          TC01005828.hg.1  1.8915231 5.949490  14.849153 1.776380e-07
##  ---                                                                     
## 468:              47419910_st  0.5186503 1.133521   5.727172 3.235860e-04
## 469:          TC19001199.hg.1  0.7629479 5.688918   5.719248 3.267530e-04
## 470:          TC02004646.hg.1 -0.6580505 3.150427  -5.713796 3.289520e-04
## 471:  TC6_cox_hap2000234.hg.1  0.7644801 7.361952   5.710209 3.304072e-04
## 472: TC6_ssto_hap7000188.hg.1  0.7644801 7.361952   5.710209 3.304072e-04
##        adj.P.Val         B
##   1: 0.001669175 7.2740862
##   2: 0.001669175 7.1564665
##   3: 0.001669175 7.1399088
##   4: 0.001669175 7.0942449
##   5: 0.001669175 6.9363380
##  ---                      
## 468: 0.048865643 0.7041169
## 469: 0.049133486 0.6947451
## 470: 0.049358891 0.6882904
## 471: 0.049367174 0.6840419
## 472: 0.049367174 0.6840419

colnames(diff.t)[1] <- "probe"
diff.t <- dplyr::left_join(diff.t,probe.gene.map,by="probe")

## Warning: Column `probe` joining character vector and factor, coercing into
## character vector

write.csv(diff.t, "nested_interactions/DE.genes.treatment.csv")
kable(diff.t) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

probe	logFC	AveExpr	t	P.Value	adj.P.Val	B	name	description
47424360_st	-3.4461924	2.704951	-17.599202	0.0000001	0.0016692	7.2740862	—	—
TC08002280.hg.1	2.1207662	3.957387	15.477227	0.0000001	0.0016692	7.1564665	—	—
TC11003279.hg.1	2.2131365	4.818089	15.428364	0.0000001	0.0016692	7.1399088	SYTL2	synaptotagmin-like 2
TC06001902.hg.1	1.9881291	5.259244	15.295015	0.0000001	0.0016692	7.0942449	ELOVL4	ELOVL fatty acid elongase 4
TC01005828.hg.1	1.8915231	5.949490	14.849153	0.0000002	0.0016692	6.9363380	FLG	filaggrin
TC02002499.hg.1	1.8076608	3.027889	14.760747	0.0000002	0.0016692	6.9040421	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit
TC02000927.hg.1	1.7994218	4.825662	14.725248	0.0000002	0.0016692	6.8909791	KIF5C	kinesin family member 5C
TC20001333.hg.1	-1.6599644	6.140878	-14.630919	0.0000002	0.0016692	6.8560032	—	—
TC11002081.hg.1	1.7538659	4.686728	14.531116	0.0000002	0.0016692	6.8185731	PGM2L1	phosphoglucomutase 2-like 1
TC02002628.hg.1	1.6233839	3.832753	14.220776	0.0000003	0.0018000	6.6993287	TMEFF2	transmembrane protein with EGF-like and two follistatin-like domains 2
TC19002526.hg.1	1.4703414	5.273655	13.846875	0.0000003	0.0019074	6.5497032	—	—
TC01005829.hg.1	2.0665511	5.425159	13.843340	0.0000003	0.0019074	6.5346444	FLG	filaggrin
TC0X000948.hg.1	1.8001431	5.112170	13.519153	0.0000004	0.0019215	6.4129373	TMEM47	transmembrane protein 47
TC12002778.hg.1	1.6273749	4.844336	13.447717	0.0000004	0.0019215	6.3824023	MGP	matrix Gla protein
TC12001282.hg.1	1.8631456	5.788827	13.441233	0.0000004	0.0019215	6.3796175	EPS8	epidermal growth factor receptor pathway substrate 8
TC08001988.hg.1	1.8214417	5.093939	12.987126	0.0000005	0.0023388	6.1790441	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
TC05000084.hg.1	1.8288241	3.977673	12.931401	0.0000006	0.0023388	6.1536578	FAM105A	family with sequence similarity 105, member A
TC01002163.hg.1	1.8546385	6.434913	12.747154	0.0000006	0.0024882	6.0684765	TNFRSF9	tumor necrosis factor receptor superfamily, member 9
TC01003245.hg.1	1.9247596	5.883388	12.514402	0.0000008	0.0027997	5.9410086	FLG	filaggrin
TC13000634.hg.1	1.7395012	5.447627	12.377968	0.0000008	0.0028566	5.8918666	SLC25A30	solute carrier family 25, member 30
TC02002747.hg.1	1.4487488	5.708147	12.200396	0.0000009	0.0030262	5.8040005	FN1	fibronectin 1
TC08001361.hg.1	1.6892916	5.429882	12.095322	0.0000010	0.0030262	5.7510858	PAG1	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
TC02004676.hg.1	1.9913662	4.388047	12.175839	0.0000010	0.0030262	5.7374297	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit
TC06002615.hg.1	2.3550982	4.838790	12.382621	0.0000011	0.0031570	5.6420336	SOX4	SRY (sex determining region Y)-box 4
TC06002062.hg.1	1.5240123	5.282369	11.718602	0.0000013	0.0034699	5.5555468	MAN1A1	mannosidase, alpha, class 1A, member 1
TC12002256.hg.1	1.5549538	6.587713	11.710977	0.0000013	0.0034699	5.5514923	—	—
TC16000258.hg.1	-1.3264497	8.990279	-11.621094	0.0000014	0.0035226	5.5034071	PLK1	polo-like kinase 1
TC02001238.hg.1	2.1624376	4.390431	11.857690	0.0000014	0.0035226	5.4596523	MAP2	microtubule-associated protein 2
47420725_st	-1.3914894	2.187253	-11.199496	0.0000018	0.0041746	5.2704085	—	—
TC05001205.hg.1	-1.3081055	5.223500	-11.166691	0.0000019	0.0041746	5.2517493	CDH10	cadherin 10, type 2 (T2-cadherin)
TC12001276.hg.1	1.2571760	3.918912	11.163699	0.0000019	0.0041746	5.2500432	MGP	matrix Gla protein
TC03000565.hg.1	2.3979132	5.854359	11.636449	0.0000019	0.0041746	5.2132456	—	—
TC18000564.hg.1	1.6410700	5.081183	11.108295	0.0000020	0.0042500	5.2113006	DSEL	dermatan sulfate epimerase-like
TC07002501.hg.1	-1.3337761	6.241683	-10.828018	0.0000024	0.0050007	5.0544622	CUX1	cut-like homeobox 1
TC06002990.hg.1	-1.3510344	7.095794	-10.800286	0.0000025	0.0050007	5.0379244	GTF3C6	general transcription factor IIIC, polypeptide 6, alpha 35kDa
TC12002552.hg.1	1.8074655	5.767873	10.817578	0.0000026	0.0050709	4.9997234	—	—
TC03000768.hg.1	1.7142208	6.515891	10.458482	0.0000033	0.0063228	4.8039575	PLS1	plastin 1
TC01001306.hg.1	1.2959592	3.121130	10.180530	0.0000040	0.0072238	4.6524134	SYT11	synaptotagmin XI
TC0X000544.hg.1	1.2661273	3.502467	10.172548	0.0000040	0.0072238	4.6472426	—	—
TC12000182.hg.1	1.3285861	6.359695	10.153210	0.0000041	0.0072238	4.6346936	GPRC5A	G protein-coupled receptor, class C, group 5, member A
TC17000551.hg.1	1.2778060	6.971147	10.096312	0.0000043	0.0073749	4.5975850	ARL4D	ADP-ribosylation factor-like 4D
TC10002572.hg.1	1.3150229	7.554689	10.018388	0.0000046	0.0076638	4.5463129	—	—
TC19000439.hg.1	-1.3278210	6.944991	-9.945911	0.0000048	0.0079368	4.4981523	KCTD15	potassium channel tetramerization domain containing 15
TC12000495.hg.1	1.0511221	5.325142	9.892992	0.0000051	0.0080081	4.4626971	DGKA	diacylglycerol kinase, alpha 80kDa
TC03000892.hg.1	1.3503341	5.787769	9.837004	0.0000053	0.0080081	4.4249162	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1
TC03000026.hg.1	1.1947936	5.697062	9.820112	0.0000054	0.0080081	4.4134624	LMCD1	LIM and cysteine-rich domains 1
TC12001755.hg.1	1.1231468	6.448835	9.808146	0.0000054	0.0080081	4.4053332	CSRP2	cysteine and glycine-rich protein 2
TC08002373.hg.1	-1.5237527	4.588725	-9.832918	0.0000055	0.0080081	4.3985511	—	—
TC19000805.hg.1	1.3514780	6.274601	9.758053	0.0000056	0.0081197	4.3711633	ERVV-2	endogenous retrovirus group V, member 2
TC11002205.hg.1	1.7964250	5.999529	9.823361	0.0000060	0.0084902	4.3121228	SESN3	sestrin 3
3676041_st	-1.1559943	9.118872	-9.631773	0.0000063	0.0085021	4.2840146	—	—
TC12000189.hg.1	1.4767802	5.941958	9.624560	0.0000064	0.0085021	4.2659260	EMP1	epithelial membrane protein 1
TC07002670.hg.1	-1.2292781	5.753313	-9.585463	0.0000065	0.0085021	4.2516891	—	—
TC02001101.hg.1	1.6243540	6.595083	9.605593	0.0000067	0.0085466	4.2305068	FAM171B	family with sequence similarity 171, member B
TC11003298.hg.1	2.4595391	6.599112	10.391736	0.0000064	0.0085021	4.2303299	SESN3	sestrin 3
3671544_st	-1.0884690	6.123616	-9.487891	0.0000071	0.0086980	4.1829275	—	—
TC04001402.hg.1	1.1139309	4.310520	9.485805	0.0000071	0.0086980	4.1814471	TSPAN5	tetraspanin 5
TC20000876.hg.1	1.9065295	8.177874	9.620480	0.0000072	0.0086980	4.1683861	SLPI	secretory leukocyte peptidase inhibitor
TC10001193.hg.1	1.1751294	6.654212	9.446276	0.0000073	0.0087479	4.1533280	CCNYL2	cyclin Y-like 2
TC09001842.hg.1	1.1130582	4.480409	9.416344	0.0000075	0.0088231	4.1319371	—	—
TC11002162.hg.1	1.1328584	4.111129	9.373392	0.0000078	0.0090012	4.1010924	SYTL2	synaptotagmin-like 2
TC06000758.hg.1	1.1131495	4.999150	9.262875	0.0000086	0.0097346	4.0209130	SH3BGRL2	SH3 domain binding glutamate-rich protein like 2
TC08000531.hg.1	1.0549273	4.853230	9.165722	0.0000093	0.0101070	3.9494465	CA2	carbonic anhydrase II
TC12001689.hg.1	-1.2129400	5.727500	-9.161245	0.0000093	0.0101070	3.9461304	GRIP1	glutamate receptor interacting protein 1
TC16001464.hg.1	1.1590483	5.261676	9.151262	0.0000094	0.0101070	3.9387303	LOC554206	leucine carboxyl methyltransferase 1 pseudogene
TC12002937.hg.1	-1.4802872	5.883468	-9.183585	0.0000095	0.0101070	3.9351715	GRIP1	glutamate receptor interacting protein 1
TC08001440.hg.1	1.1666654	4.787639	9.069091	0.0000101	0.0105687	3.8774375	TP53INP1	tumor protein p53 inducible nuclear protein 1
3671548_st	-1.4836133	4.824891	-9.113471	0.0000102	0.0105687	3.8713656	—	—
TC03000865.hg.1	1.2314527	7.838267	9.016597	0.0000106	0.0107169	3.8379264	MLF1	myeloid leukemia factor 1
TC07001206.hg.1	1.4518641	4.512968	9.059541	0.0000107	0.0107169	3.8335086	OSBPL3	oxysterol binding protein-like 3
TC0X001624.hg.1	1.8457667	8.714992	9.172724	0.0000108	0.0107169	3.8209751	SAT1	spermidine/spermine N1-acetyltransferase 1
TC17002655.hg.1	-1.2867975	7.735119	-8.950226	0.0000112	0.0110117	3.7875722	UBTF	upstream binding transcription factor, RNA polymerase I
TC22000350.hg.1	1.0734628	5.273122	8.863720	0.0000121	0.0114159	3.7212634	SEPT3	septin 3
TC01005517.hg.1	-1.3488981	4.666076	-8.886785	0.0000121	0.0114159	3.7206385	DAB1	Dab, reelin signal transducer, homolog 1 (Drosophila)
TC08000505.hg.1	1.1490553	4.838196	8.862739	0.0000122	0.0114159	3.7205070	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
TC04001347.hg.1	1.2499946	5.034731	8.848879	0.0000123	0.0114159	3.7098103	HPSE	heparanase
TC05002634.hg.1	-0.9956503	6.672090	-8.779063	0.0000131	0.0119557	3.6556217	JADE2	jade family PHD finger 2
TC02002574.hg.1	1.0407107	5.082342	8.768391	0.0000132	0.0119557	3.6472938	FKBP7	FK506 binding protein 7
TC01003017.hg.1	1.3910447	5.856842	8.750531	0.0000138	0.0122853	3.6126935	TSPAN2	tetraspanin 2
TC05001411.hg.1	1.2094391	6.628636	8.694237	0.0000141	0.0123998	3.5890942	SGTB	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
TC19001563.hg.1	1.0084848	6.097101	8.686259	0.0000142	0.0123998	3.5827982	ATP1A3	ATPase, Na+/K+ transporting, alpha 3 polypeptide
TC18000208.hg.1	-0.9668374	6.400822	-8.651718	0.0000147	0.0126390	3.5554600	ZNF532	zinc finger protein 532
TC13000234.hg.1	1.2012468	3.523813	8.586923	0.0000156	0.0130703	3.5038317	PCDH17	protocadherin 17
TC13001320.hg.1	1.1063789	2.910578	8.586636	0.0000156	0.0130703	3.5036023	GAS6-AS2	GAS6 antisense RNA 2 (head to head)
TC16000266.hg.1	1.1026210	5.400250	8.575631	0.0000158	0.0130703	3.4947885	LOC554206	leucine carboxyl methyltransferase 1 pseudogene
PSR17013958.hg.1	-1.0402467	8.306628	-8.546350	0.0000162	0.0132702	3.4712725	—	—
TC04002014.hg.1	-0.9810243	5.726682	-8.396002	0.0000186	0.0148370	3.3490501	DANCR	differentiation antagonizing non-protein coding RNA
TC03000482.hg.1	1.1060757	2.572256	8.387664	0.0000187	0.0148370	3.3421993	OR5AC2	olfactory receptor, family 5, subfamily AC, member 2
TC20000481.hg.1	-1.0303784	6.687764	-8.374821	0.0000190	0.0148370	3.3316313	CDH4	cadherin 4, type 1, R-cadherin (retinal)
TC14001140.hg.1	1.2537434	5.741637	8.367741	0.0000192	0.0148370	3.3206619	TXNDC16	thioredoxin domain containing 16
TC03003361.hg.1	1.0169454	4.567233	8.351385	0.0000194	0.0148370	3.3122985	PLCXD2	phosphatidylinositol-specific phospholipase C, X domain containing 2
TC07001873.hg.1	1.4258965	5.264368	8.403800	0.0000196	0.0148370	3.3056871	MKLN1-AS	MKLN1 antisense RNA
TC12001170.hg.1	1.3579001	9.257128	8.362942	0.0000196	0.0148370	3.3047797	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
TC12000656.hg.1	-0.9454655	4.274430	-8.318067	0.0000200	0.0149696	3.2847083	NAV3	neuron navigator 3
TC05002611.hg.1	1.0063621	6.997704	8.309618	0.0000202	0.0149696	3.2776913	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TC0X001186.hg.1	1.0639356	3.675769	8.263582	0.0000211	0.0154703	3.2393199	RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6
TC06000886.hg.1	-0.9693636	6.465504	-8.244551	0.0000214	0.0155887	3.2233869	GTF3C6	general transcription factor IIIC, polypeptide 6, alpha 35kDa
TC09000899.hg.1	0.9282196	5.532533	8.226612	0.0000218	0.0156939	3.2083301	GLDC	glycine dehydrogenase (decarboxylating)
TC01002772.hg.1	1.1714468	7.990361	8.155817	0.0000233	0.0165407	3.1485508	RP11-180O5.2	putative novel transcript
TC05002418.hg.1	-0.9600865	9.275660	-8.150117	0.0000235	0.0165407	3.1437129	CCNB1	cyclin B1
TC07000718.hg.1	1.4656189	6.813746	8.192583	0.0000238	0.0166187	3.1323662	TES	testis derived transcript (3 LIM domains)
TC12001907.hg.1	1.2965294	6.131961	8.124526	0.0000245	0.0169396	3.1055034	—	—
TC17000720.hg.1	1.4912223	5.241780	8.182559	0.0000257	0.0173553	3.0651217	GDPD1	glycerophosphodiester phosphodiesterase domain containing 1
TC06001952.hg.1	0.8115401	2.545895	8.056097	0.0000257	0.0173553	3.0633644	EPHA7	EPH receptor A7
TC18000142.hg.1	0.9157598	6.068972	8.042143	0.0000260	0.0173553	3.0513515	MAPRE2	microtubule-associated protein, RP/EB family, member 2
TC06002112.hg.1	1.0820990	6.964645	8.039324	0.0000261	0.0173553	3.0489213	CTGF	connective tissue growth factor
TC03002443.hg.1	-0.9214013	5.649479	-8.022063	0.0000265	0.0174821	3.0340246	—	—
TC0X002342.hg.1	1.1850741	3.212648	8.019596	0.0000269	0.0175975	3.0203387	SPANXC	SPANX family, member C
TC07003174.hg.1	1.3441498	4.827474	8.033172	0.0000277	0.0179357	2.9966426	MKLN1-AS	MKLN1 antisense RNA
TC08001062.hg.1	2.1140013	5.932169	8.733190	0.0000284	0.0180160	2.9886004	STC1	stanniocalcin 1
TC15000449.hg.1	-0.9340503	7.413459	-7.954713	0.0000283	0.0180160	2.9755604	CCNB2	cyclin B2
TC08001532.hg.1	0.9104782	4.514424	7.943996	0.0000286	0.0180160	2.9662086	KCNV1	potassium channel, subfamily V, member 1
TC04000611.hg.1	1.5061177	7.693989	7.995499	0.0000289	0.0180301	2.9599414	USP53	ubiquitin specific peptidase 53
TC12003271.hg.1	1.2100117	4.061267	7.936877	0.0000294	0.0181587	2.9440412	KLRC3	killer cell lectin-like receptor subfamily C, member 3
TC04002753.hg.1	1.5331342	6.285086	8.032054	0.0000299	0.0181671	2.9323935	CLGN	calmegin
TC07000329.hg.1	-0.9173481	6.736352	-7.901829	0.0000298	0.0181671	2.9292768	LANCL2	LanC lantibiotic synthetase component C-like 2 (bacterial)
TC17001711.hg.1	0.9700029	6.257315	7.868429	0.0000308	0.0185686	2.8998716	MMD	monocyte to macrophage differentiation-associated
TC0X000112.hg.1	1.5480488	6.598943	7.984468	0.0000313	0.0186105	2.8920504	SAT1	spermidine/spermine N1-acetyltransferase 1
TC07001184.hg.1	1.6117781	5.937347	8.027798	0.0000321	0.0186105	2.8717089	CDCA7L	cell division cycle associated 7-like
TC06002829.hg.1	1.2601403	6.456125	7.850972	0.0000319	0.0186105	2.8687320	EFHC1	EF-hand domain (C-terminal) containing 1
TC12002824.hg.1	1.1213175	6.153465	7.828761	0.0000320	0.0186105	2.8647741	AMN1	antagonist of mitotic exit network 1 homolog (S. cerevisiae)
TC02004895.hg.1	-1.0267967	4.677270	-7.823590	0.0000322	0.0186105	2.8601848	—	—
TC02004510.hg.1	0.9386547	5.754968	7.814305	0.0000325	0.0186290	2.8519370	—	—
TC03001169.hg.1	0.9354939	5.365239	7.805377	0.0000328	0.0186423	2.8439950	TIMP4	TIMP metallopeptidase inhibitor 4
TC05003028.hg.1	1.2534141	5.599987	7.797077	0.0000340	0.0191978	2.8117081	—	—
PSR17013959.hg.1	-0.9072309	4.887992	-7.725402	0.0000355	0.0197567	2.7724252	—	—
TC04000462.hg.1	1.3615095	5.659314	7.777587	0.0000359	0.0197567	2.7661004	CDS1	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
TC14000211.hg.1	-0.8532559	5.543937	-7.715159	0.0000358	0.0197567	2.7632017	NPAS3	neuronal PAS domain protein 3
TC13000741.hg.1	1.0407772	4.568937	7.678082	0.0000372	0.0202782	2.7297078	KCTD12	potassium channel tetramerization domain containing 12
TC07000111.hg.1	1.4733531	6.698229	7.755367	0.0000379	0.0202782	2.7185050	TSPAN13	tetraspanin 13
TC03002690.hg.1	1.0008760	2.836051	7.659090	0.0000379	0.0202782	2.7124847	—	—
TC06000110.hg.1	1.0134404	6.277864	7.657981	0.0000380	0.0202782	2.7114778	GMPR	guanosine monophosphate reductase
TC12003243.hg.1	0.9117554	5.963796	7.643262	0.0000385	0.0203452	2.6980977	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC12002734.hg.1	1.4105145	10.329069	7.731161	0.0000389	0.0203452	2.6951658	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3
TC05000262.hg.1	1.3060980	6.950752	7.647823	0.0000395	0.0203452	2.6779927	ZSWIM6	zinc finger, SWIM-type containing 6
TC07000112.hg.1	1.3120690	7.832356	7.639820	0.0000394	0.0203452	2.6776361	AHR	aryl hydrocarbon receptor
TC04000297.hg.1	-1.0680944	5.885307	-7.617409	0.0000395	0.0203452	2.6745293	DANCR	differentiation antagonizing non-protein coding RNA
TC18000741.hg.1	1.5893643	7.802471	7.746771	0.0000399	0.0203452	2.6731010	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
TC04001589.hg.1	1.3454347	5.548345	7.660866	0.0000404	0.0203452	2.6588041	CLGN	calmegin
TC05001610.hg.1	1.1095369	6.864237	7.599762	0.0000402	0.0203452	2.6583946	ELL2	elongation factor, RNA polymerase II, 2
TC16000455.hg.1	1.0542567	6.233383	7.577297	0.0000412	0.0205549	2.6377981	LPCAT2	lysophosphatidylcholine acyltransferase 2
TC05001021.hg.1	1.1237880	3.619759	7.574465	0.0000417	0.0205549	2.6268841	RP11-1101H11.1	putative novel transcript
TC07000688.hg.1	1.0094950	6.205444	7.560840	0.0000419	0.0205549	2.6226688	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta
TC21000025.hg.1	1.2052739	4.255856	7.588809	0.0000420	0.0205549	2.6220323	RBM11	RNA binding motif protein 11
TC15000410.hg.1	1.0224364	5.078128	7.545277	0.0000425	0.0205955	2.6083303	TMOD2	tropomodulin 2 (neuronal)
TC05000298.hg.1	-0.9219693	8.365858	-7.542573	0.0000426	0.0205955	2.6058364	CCNB1	cyclin B1
TC12002835.hg.1	0.9529796	4.241214	7.535668	0.0000429	0.0205991	2.5994629	—	—
TC05000604.hg.1	-0.9904518	7.712848	-7.514830	0.0000439	0.0208976	2.5801910	LMNB1	lamin B1
TC13000161.hg.1	1.0778941	6.296975	7.501755	0.0000444	0.0210076	2.5680704	LACC1	laccase (multicopper oxidoreductase) domain containing 1
TC08002532.hg.1	-1.0006715	6.481312	-7.486380	0.0000451	0.0210076	2.5537903	—	—
TC07000741.hg.1	0.9023875	4.242974	7.480321	0.0000454	0.0210076	2.5481549	FEZF1-AS1	FEZF1 antisense RNA 1
TC08001816.hg.1	1.3331833	6.020214	7.524134	0.0000460	0.0210076	2.5401448	SLC7A2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TC02002445.hg.1	0.8867644	4.658045	7.471128	0.0000459	0.0210076	2.5395951	NR4A2	nuclear receptor subfamily 4, group A, member 2
TC08002129.hg.1	-0.9729401	6.961048	-7.468590	0.0000460	0.0210076	2.5372293	CHRAC1	chromatin accessibility complex 1
3676043_st	-1.2745670	8.992440	-7.490389	0.0000462	0.0210076	2.5343853	—	—
TC10000639.hg.1	1.1729426	3.269669	7.486101	0.0000465	0.0210076	2.5290286	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
TC12003080.hg.1	1.2627441	4.154375	7.501323	0.0000468	0.0210076	2.5248319	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2
3662477_st	-0.9389367	6.701402	-7.427070	0.0000480	0.0213194	2.4984209	—	—
TC12001226.hg.1	1.0461610	4.262532	7.425073	0.0000481	0.0213194	2.4965492	STYK1	serine/threonine/tyrosine kinase 1
TC0X000800.hg.1	1.1390488	6.752023	7.409059	0.0000489	0.0214246	2.4815178	ASMTL	acetylserotonin O-methyltransferase-like
TC12001798.hg.1	1.3781205	7.584611	7.444880	0.0000495	0.0214246	2.4727051	ATP2B1	ATPase, Ca++ transporting, plasma membrane 1
TC06002832.hg.1	0.9171582	5.271884	7.398987	0.0000494	0.0214246	2.4720458	LOC730101	uncharacterized LOC730101
TC06000779.hg.1	0.8544207	5.377653	7.396875	0.0000495	0.0214246	2.4700584	NT5E	5-nucleotidase, ecto (CD73)
TC06000985.hg.1	1.1737142	5.681834	7.400721	0.0000503	0.0215940	2.4570955	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1
TC08001253.hg.1	0.9353128	4.520402	7.376620	0.0000505	0.0215940	2.4509664	CA8	carbonic anhydrase VIII
TC01004733.hg.1	-1.1213604	4.333175	-7.362667	0.0000521	0.0221491	2.4233919	RP11-107M16.2	novel transcript
TC15001394.hg.1	-0.7736122	1.983404	-7.333431	0.0000528	0.0223091	2.4100803	—	—
TC0X001197.hg.1	0.8868049	4.993246	7.322608	0.0000534	0.0224264	2.3997967	NAP1L3	nucleosome assembly protein 1-like 3
TC0X001522.hg.1	-1.1422297	7.486754	-7.309813	0.0000541	0.0225916	2.3876194	HCFC1	host cell factor C1
TC03001175.hg.1	0.9366391	5.936475	7.301107	0.0000546	0.0226627	2.3793217	TMEM40	transmembrane protein 40
TC08000493.hg.1	1.2248354	5.926125	7.321374	0.0000554	0.0227158	2.3690140	GDAP1	ganglioside induced differentiation associated protein 1
47419721_st	0.7059130	1.237500	7.287611	0.0000554	0.0227158	2.3664381	—	—
TC0X001610.hg.1	1.2407282	2.922638	7.314390	0.0000574	0.0233912	2.3382278	REPS2	RALBP1 associated Eps domain containing 2
TC02001128.hg.1	1.2474757	7.891987	7.257967	0.0000582	0.0233912	2.3219259	NABP1	nucleic acid binding protein 1
TC01005153.hg.1	-1.0402778	5.388331	-7.236245	0.0000585	0.0233912	2.3171850	EFCAB2	EF-hand calcium binding domain 2
TC06000010.hg.1	-1.1226739	5.812012	-7.250894	0.0000585	0.0233912	2.3171839	FOXF2	forkhead box F2
TC20000621.hg.1	0.9131377	5.895657	7.223075	0.0000593	0.0233912	2.3045008	JAG1	jagged 1
PSR17016921.hg.1	-0.8908513	8.418035	-7.215551	0.0000597	0.0233912	2.2972442	—	—
TC10002135.hg.1	-1.0386059	5.195055	-7.215239	0.0000598	0.0233912	2.2969431	ZNF503-AS1	novel transcript (LOC253264)
TC07001192.hg.1	1.2823876	7.495073	7.241886	0.0000600	0.0233912	2.2951244	FAM126A	family with sequence similarity 126, member A
TC05002954.hg.1	0.9618107	7.043297	7.210744	0.0000600	0.0233912	2.2926038	—	—
PSR17016934.hg.1	-0.9504839	9.226823	-7.190361	0.0000613	0.0235502	2.2728939	—	—
TC11001505.hg.1	-0.8116615	2.771855	-7.188747	0.0000614	0.0235502	2.2713307	MUC15	mucin 15, cell surface associated
TC17000728.hg.1	1.3081623	4.415792	7.276490	0.0000621	0.0235502	2.2691744	MIR21	microRNA 21
TC03003151.hg.1	0.9053063	5.001779	7.184900	0.0000617	0.0235502	2.2676038	—	—
TC0X001832.hg.1	1.0360179	3.109635	7.185994	0.0000619	0.0235502	2.2644826	—	—
TC19000081.hg.1	0.9118563	4.768912	7.172264	0.0000625	0.0235749	2.2553483	CREB3L3	cAMP responsive element binding protein 3-like 3
TC0X000442.hg.1	1.3025213	3.628755	7.250366	0.0000638	0.0239201	2.2445725	ZNF711	zinc finger protein 711
TC10002843.hg.1	-1.5363549	8.052174	-7.301147	0.0000642	0.0239201	2.2435014	GFRA1	GDNF family receptor alpha 1
TC03001074.hg.1	0.8718831	4.490431	7.134445	0.0000651	0.0239201	2.2185401	LINC00884	long intergenic non-protein coding RNA 884
47422171_st	-1.0943114	2.243462	-7.174274	0.0000654	0.0239201	2.2170790	—	—
PSR17013956.hg.1	-0.7922473	6.505301	-7.121004	0.0000660	0.0239201	2.2054120	—	—
TC14001730.hg.1	0.9439656	4.295980	7.116364	0.0000663	0.0239201	2.2008748	AKAP5	A kinase (PRKA) anchor protein 5
47419687_st	-0.8795208	1.488180	-7.125020	0.0000668	0.0239201	2.1956059	—	—
TC04000868.hg.1	1.3177561	5.416619	7.202314	0.0000673	0.0239201	2.1952414	WDR17	WD repeat domain 17
TC06000628.hg.1	0.9764050	5.136647	7.102859	0.0000673	0.0239201	2.1876519	SLC25A27	solute carrier family 25, member 27
TC18000610.hg.1	1.4820566	6.105710	7.254099	0.0000685	0.0239201	2.1848469	—	—
TC0Y000117.hg.1	1.1501308	6.898694	7.102185	0.0000681	0.0239201	2.1769926	ASMTL	acetylserotonin O-methyltransferase-like
TC15000945.hg.1	1.1167918	5.338734	7.104172	0.0000684	0.0239201	2.1732993	ARRDC4	arrestin domain containing 4
TC12002388.hg.1	0.8451165	4.458115	7.087586	0.0000684	0.0239201	2.1726679	ERBB3	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC05001011.hg.1	-0.9102596	6.469049	-7.086907	0.0000684	0.0239201	2.1720009	NSD1	nuclear receptor binding SET domain protein 1
TC0X000689.hg.1	0.7930501	3.551168	7.086268	0.0000685	0.0239201	2.1713733	SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1
TC12000263.hg.1	0.9462376	7.136140	7.031831	0.0000726	0.0252049	2.1177010	STK38L	serine/threonine kinase 38 like
TC17002317.hg.1	0.7690213	3.810179	7.017596	0.0000737	0.0254194	2.1035988	—	—
TC02002218.hg.1	2.4970012	4.984087	8.383758	0.0000801	0.0260996	2.1024513	IL1A	interleukin 1, alpha
TC01001372.hg.1	1.1353267	5.716318	7.028359	0.0000747	0.0254194	2.0927454	SLAMF7	SLAM family member 7
TC01002884.hg.1	0.9572004	6.319686	6.992510	0.0000757	0.0254194	2.0786811	ARHGAP29	Rho GTPase activating protein 29
TC04002625.hg.1	1.1986762	6.901829	7.013945	0.0000759	0.0254194	2.0785251	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
TC14001079.hg.1	0.9699705	6.295800	6.986923	0.0000761	0.0254194	2.0731200	KLHL28	kelch-like family member 28
TC03002202.hg.1	-0.9286518	3.551214	-6.984959	0.0000763	0.0254194	2.0711636	—	—
TC01001212.hg.1	1.1701235	7.579326	6.997878	0.0000764	0.0254194	2.0706463	TUFT1	tuftelin 1
TC06000978.hg.1	0.8431174	4.949912	6.983369	0.0000764	0.0254194	2.0695799	L3MBTL3	l(3)mbt-like 3 (Drosophila)
TC07000707.hg.1	0.9940955	6.577841	6.981676	0.0000766	0.0254194	2.0678933	ZNF277	zinc finger protein 277
TC02002430.hg.1	0.7588893	4.829386	6.976609	0.0000770	0.0254194	2.0628421	CACNB4	calcium channel, voltage-dependent, beta 4 subunit
TC08000788.hg.1	-0.8481934	6.415133	-6.974678	0.0000771	0.0254194	2.0609159	CHRAC1	chromatin accessibility complex 1
TC11001686.hg.1	0.7827213	1.602793	6.947018	0.0000795	0.0260657	2.0332740	—	—
TC08001120.hg.1	0.7885252	5.345190	6.937227	0.0000803	0.0260996	2.0234646	RNF122	ring finger protein 122
TC18000674.hg.1	1.3073141	7.592093	6.964765	0.0000820	0.0262723	2.0088739	—	—
TC12002858.hg.1	1.2735920	6.096841	6.980736	0.0000824	0.0262723	2.0066366	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor
TC16001433.hg.1	-0.7974435	6.203947	-6.915204	0.0000822	0.0262723	2.0013504	ITPRIPL2	inositol 1,4,5-trisphosphate receptor interacting protein-like 2
TC02003747.hg.1	1.1383780	9.111825	6.927508	0.0000824	0.0262723	2.0005380	—	—
TC18000213.hg.1	1.3618599	7.999479	6.963731	0.0000844	0.0262723	1.9850002	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
TC08001683.hg.1	-0.8178217	6.766000	-6.898667	0.0000837	0.0262723	1.9847012	CASC7	cancer susceptibility candidate 7 (non-protein coding)
TC12000406.hg.1	0.7392552	4.318083	6.898212	0.0000838	0.0262723	1.9842429	SLC4A8	solute carrier family 4, sodium bicarbonate cotransporter, member 8
TC02002425.hg.1	-1.0193094	6.133916	-6.896933	0.0000839	0.0262723	1.9829536	NMI	N-myc (and STAT) interactor
TC06000135.hg.1	0.9524656	5.665812	6.894026	0.0000841	0.0262723	1.9800221	SOX4	SRY (sex determining region Y)-box 4
TC06000657.hg.1	1.0293596	4.882059	6.898875	0.0000846	0.0262723	1.9763587	LOC730101	uncharacterized LOC730101
TC05002066.hg.1	1.1888676	7.190728	6.908588	0.0000849	0.0262723	1.9737180	DUSP1	dual specificity phosphatase 1
TC12001168.hg.1	1.0202251	6.354506	6.872953	0.0000861	0.0265142	1.9587382	SLC2A14	solute carrier family 2 (facilitated glucose transporter), member 14
TC15002198.hg.1	1.3754453	2.712319	7.074599	0.0000883	0.0266624	1.9573088	TMOD2	tropomodulin 2 (neuronal)
TC06000684.hg.1	-0.9272867	8.286831	-6.861549	0.0000872	0.0265891	1.9471941	BAG2	BCL2-associated athanogene 2
TC02002436.hg.1	-0.8944619	4.458407	-6.861042	0.0000872	0.0265891	1.9466799	AC012501.2	putative novel transcript
TC07000874.hg.1	-0.7799338	2.165423	-6.858387	0.0000875	0.0265891	1.9439903	PP12708	—
TC02000608.hg.1	-0.7772257	6.432897	-6.847974	0.0000885	0.0266624	1.9334289	PDCL3	phosducin-like 3
PSR17014493.hg.1	-0.8263007	8.094718	-6.841699	0.0000891	0.0267158	1.9270572	—	—
TC02001388.hg.1	0.7484527	5.348798	6.838326	0.0000894	0.0267158	1.9236301	ARMC9	armadillo repeat containing 9
TC01005830.hg.1	2.3736907	4.657497	8.088899	0.0000985	0.0282084	1.9224811	FLG	filaggrin
TC22000139.hg.1	-0.8532525	6.524766	-6.831922	0.0000900	0.0267895	1.9171186	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
47422105_st	-0.9302681	1.621533	-6.848873	0.0000913	0.0269957	1.9074808	—	—
TC05000612.hg.1	0.8481848	6.756171	6.817205	0.0000915	0.0269957	1.9021328	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TC05000736.hg.1	0.9980925	3.781531	6.815835	0.0000921	0.0270486	1.8968695	VTRNA1-3	vault RNA 1-3
TC02004734.hg.1	-1.2104849	3.553904	-6.874624	0.0000928	0.0271493	1.8965177	PDE1A	phosphodiesterase 1A, calmodulin-dependent
TC09002903.hg.1	0.9445228	6.189535	6.796219	0.0000936	0.0272678	1.8807117	TMEFF1	transmembrane protein with EGF-like and two follistatin-like domains 1
TC19002497.hg.1	1.5550055	5.770804	7.069911	0.0000970	0.0279789	1.8781318	—	—
3671552_st	-1.0596475	7.107991	-6.792868	0.0000940	0.0272678	1.8772857	—	—
TC16000823.hg.1	-1.0188757	7.810055	-6.761935	0.0000972	0.0279789	1.8455837	CREBBP	CREB binding protein
TC08000324.hg.1	1.0158222	6.594341	6.743834	0.0000992	0.0282084	1.8269702	AP3M2	adaptor-related protein complex 3, mu 2 subunit
TC12003272.hg.1	0.8820735	3.611302	6.743445	0.0000992	0.0282084	1.8265701	KLRC2	killer cell lectin-like receptor subfamily C, member 2
PSR17008059.hg.1	-0.9534665	7.019740	-6.727859	0.0001009	0.0285819	1.8105051	—	—
TC02004860.hg.1	1.3372441	5.733590	6.833932	0.0001046	0.0294032	1.7919297	—	—
TC02000357.hg.1	0.7784111	5.660929	6.701624	0.0001039	0.0293046	1.7833859	B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
TC08001156.hg.1	0.9490486	7.663290	6.684953	0.0001058	0.0294751	1.7661019	TM2D2	TM2 domain containing 2
TC06000655.hg.1	1.0078166	5.645194	6.687160	0.0001064	0.0294751	1.7615464	EFHC1	EF-hand domain (C-terminal) containing 1
TC03001812.hg.1	-1.1757200	6.469177	-6.713862	0.0001070	0.0294751	1.7602705	STAG1	stromal antigen 1
3670189_st	-0.7729881	9.682810	-6.678847	0.0001065	0.0294751	1.7597615	—	—
TC0X001257.hg.1	0.8359029	6.260345	6.676514	0.0001068	0.0294751	1.7573376	MORC4	MORC family CW-type zinc finger 4
TC03002727.hg.1	-0.7051817	2.250786	-6.669059	0.0001077	0.0295538	1.7495873	—	—
TC04001698.hg.1	0.9754454	4.479152	6.662528	0.0001090	0.0296788	1.7390554	NPY1R	neuropeptide Y receptor Y1
TC06000117.hg.1	0.8235803	7.329613	6.658276	0.0001090	0.0296788	1.7383627	KDM1B	lysine (K)-specific demethylase 1B
TC06001510.hg.1	1.2579441	5.924614	6.730517	0.0001109	0.0298118	1.7324591	IER3	immediate early response 3
TC03002941.hg.1	0.8709285	4.476906	6.651105	0.0001099	0.0298013	1.7308886	PTPRG-AS1	PTPRG antisense RNA 1
TC02001974.hg.1	1.0767645	5.601519	6.665267	0.0001110	0.0298118	1.7238454	PAIP2B	poly(A) binding protein interacting protein 2B
3015381_st	-1.0357170	6.318625	-6.647824	0.0001112	0.0298118	1.7206825	—	—
TC08001736.hg.1	0.8554051	4.199063	6.629031	0.0001126	0.0300384	1.7078354	EPPK1	epiplakin 1
TC01001427.hg.1	0.8702537	3.449768	6.626881	0.0001129	0.0300384	1.7055867	RGS4	regulator of G-protein signaling 4
TC06001548.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_apd_hap1000089.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_dbb_hap3000164.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_mann_hap4000146.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_mcf_hap5000150.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_qbl_hap6000165.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC6_ssto_hap7000144.hg.1	0.9311797	7.222094	6.587840	0.0001179	0.0305701	1.6646309	NEU1	sialidase 1 (lysosomal sialidase)
TC0X000121.hg.1	0.8255278	6.099373	6.580295	0.0001189	0.0307166	1.6566903	SCARNA23	small Cajal body-specific RNA 23
TC03003286.hg.1	-0.7808119	3.558113	-6.565634	0.0001209	0.0310781	1.6412385	—	—
TC17000702.hg.1	0.7985123	7.061974	6.563350	0.0001212	0.0310781	1.6388284	SCPEP1	serine carboxypeptidase 1
TC08001432.hg.1	1.1469482	4.894874	6.600874	0.0001228	0.0311575	1.6324127	GEM	GTP binding protein overexpressed in skeletal muscle
TC13000855.hg.1	0.7915040	6.444858	6.554190	0.0001224	0.0311575	1.6291548	KDELC1	KDEL (Lys-Asp-Glu-Leu) containing 1
TC06002880.hg.1	0.7849948	5.345946	6.553735	0.0001225	0.0311575	1.6286736	MYO6	myosin VI
TC01001777.hg.1	1.5297193	5.601113	6.857458	0.0001280	0.0316752	1.6269212	ATF3	activating transcription factor 3
TC01005049.hg.1	-1.1319893	6.639860	-6.568261	0.0001242	0.0312584	1.6188175	BROX	BRO1 domain and CAAX motif containing
TC02001911.hg.1	0.9097157	4.318133	6.543637	0.0001239	0.0312584	1.6179951	PELI1	pellino E3 ubiquitin protein ligase 1
TC08001138.hg.1	0.8076768	5.467354	6.539001	0.0001245	0.0312584	1.6130878	RAB11FIP1	RAB11 family interacting protein 1 (class I)
3671554_st	-0.9219272	8.315795	-6.533239	0.0001254	0.0313502	1.6069836	—	—
TC08000709.hg.1	-0.7708811	5.611442	-6.528996	0.0001260	0.0313891	1.6024861	ZHX2	zinc fingers and homeoboxes 2
TC15000270.hg.1	1.9200345	6.179655	7.220309	0.0001371	0.0328159	1.6017627	THBS1	thrombospondin 1
TC06003411.hg.1	0.8193617	5.989058	6.516934	0.0001277	0.0316752	1.5896851	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1
TC19000306.hg.1	-0.7716546	5.611057	-6.500347	0.0001301	0.0320169	1.5720477	—	—
TC0X002341.hg.1	0.7937996	4.009933	6.499007	0.0001303	0.0320169	1.5706219	SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1
TC20000819.hg.1	-0.7222459	6.176432	-6.495707	0.0001308	0.0320250	1.5671072	SOGA1	suppressor of glucose, autophagy associated 1
TC03000465.hg.1	1.0350065	6.797562	6.491626	0.0001324	0.0323166	1.5562226	ZNF654	zinc finger protein 654
TC06002708.hg.1	0.8813023	7.708676	6.481213	0.0001329	0.0323300	1.5516528	—	—
TC01001505.hg.1	0.9374586	6.547047	6.470647	0.0001345	0.0325676	1.5403671	SUCO	SUN domain containing ossification factor
TC01003497.hg.1	0.9839751	7.409502	6.467872	0.0001350	0.0325676	1.5374007	SLC19A2	solute carrier family 19 (thiamine transporter), member 2
TC11001173.hg.1	-0.8156829	6.904877	-6.465670	0.0001353	0.0325676	1.5350454	DCPS	decapping enzyme, scavenger
TC03002108.hg.1	1.4291121	8.335719	6.579311	0.0001392	0.0331523	1.5263435	CLDN1	claudin 1
TC01005133.hg.1	-0.7880282	5.278548	-6.452985	0.0001373	0.0328159	1.5214659	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase
TC03000149.hg.1	0.9740312	4.469729	6.450661	0.0001396	0.0331523	1.5071690	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)
TC6_cox_hap2000175.hg.1	0.9180370	7.171267	6.434092	0.0001403	0.0331908	1.5011963	NEU1	sialidase 1 (lysosomal sialidase)
TC02000978.hg.1	0.7094760	4.983194	6.428667	0.0001411	0.0332847	1.4953676	GCA	grancalcin, EF-hand calcium binding protein
TC11001685.hg.1	-0.8344499	4.293853	-6.425688	0.0001416	0.0332865	1.4921642	—	—
TC05003094.hg.1	-1.2445969	6.530065	-6.491929	0.0001441	0.0336240	1.4867565	—	—
TC17000550.hg.1	1.0442255	6.455590	6.422831	0.0001441	0.0336240	1.4773652	—	—
TC07002826.hg.1	1.0498775	4.761348	6.434782	0.0001445	0.0336240	1.4768938	KLHL7-AS1	KLHL7 antisense RNA 1 (head to head)
TC12000822.hg.1	0.9176831	4.131558	6.393465	0.0001469	0.0340788	1.4574332	TCP11L2	t-complex 11, testis-specific-like 2
TC10001050.hg.1	-0.7771535	7.088160	-6.384671	0.0001484	0.0343104	1.4479280	SEPHS1	selenophosphate synthetase 1
TC0X000073.hg.1	0.6919854	3.546173	6.376368	0.0001498	0.0344823	1.4389434	GRPR	gastrin-releasing peptide receptor
TC06000770.hg.1	0.8507606	5.538902	6.374596	0.0001501	0.0344823	1.4370247	RWDD2A	RWD domain containing 2A
TC03003320.hg.1	0.8203543	6.185271	6.366095	0.0001516	0.0347068	1.4278120	NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
TC01001624.hg.1	1.6472974	4.542735	6.830701	0.0001656	0.0357112	1.4110732	RGS2	regulator of G-protein signaling 2
TC6_mann_hap4000173.hg.1	-0.7834004	6.756915	-6.348908	0.0001546	0.0352835	1.4091555	VPS52	vacuolar protein sorting 52 homolog (S. cerevisiae)
TC08001612.hg.1	-2.3613843	3.636100	-7.564361	0.0001775	0.0368806	1.4087910	—	—
TC03000023.hg.1	-0.9791685	3.077264	-6.359074	0.0001562	0.0354062	1.4020888	AC069277.2	novel transcript
TC16000660.hg.1	0.8372243	5.215369	6.341347	0.0001559	0.0354062	1.4009343	CRISPLD2	cysteine-rich secretory protein LCCL domain containing 2
PSR17016929.hg.1	-1.0439576	9.953873	-6.356393	0.0001568	0.0354062	1.3988490	—	—
TC06000178.hg.1	0.9347534	6.003711	6.332150	0.0001576	0.0354062	1.3909219	HIST1H2BI	histone cluster 1, H2bi
TC07001761.hg.1	1.0381188	4.072150	6.352784	0.0001586	0.0354062	1.3888310	DOCK4	dedicator of cytokinesis 4
TC12002570.hg.1	-0.7371558	4.373392	-6.327796	0.0001584	0.0354062	1.3861780	ADAM1A	ADAM metallopeptidase domain 1A, pseudogene
TC08002551.hg.1	-0.8091739	7.065517	-6.322330	0.0001594	0.0354062	1.3802184	—	—
TC03001047.hg.1	0.8085177	4.749936	6.321842	0.0001595	0.0354062	1.3796856	IL1RAP	interleukin 1 receptor accessory protein
TC04001325.hg.1	0.7564997	5.113254	6.320929	0.0001597	0.0354062	1.3786903	PAQR3	progestin and adipoQ receptor family member III
TC14001127.hg.1	0.7752779	4.307274	6.312458	0.0001612	0.0355773	1.3694436	TRIM9	tripartite motif containing 9
TC08001990.hg.1	0.7228161	4.253445	6.311306	0.0001614	0.0355773	1.3681848	ZC2HC1A	zinc finger, C2HC-type containing 1A
TC07001363.hg.1	-0.7778540	6.664867	-6.304513	0.0001627	0.0357112	1.3607602	TNS3	tensin 3
TC03001077.hg.1	0.8750895	5.680202	6.301348	0.0001633	0.0357112	1.3572993	FAM43A	family with sequence similarity 43, member A
TC12001296.hg.1	1.0332493	8.673444	6.305009	0.0001641	0.0357112	1.3538682	RECQL	RecQ helicase-like
TC16000209.hg.1	-0.7115412	6.371886	-6.295643	0.0001644	0.0357112	1.3510565	COQ7	coenzyme Q7 homolog, ubiquinone (yeast)
TC03003146.hg.1	0.7607602	3.360582	6.290970	0.0001653	0.0357112	1.3459392	—	—
TC06000185.hg.1	0.8587338	6.225931	6.290518	0.0001654	0.0357112	1.3454436	BTN2A2	butyrophilin, subfamily 2, member A2
PSR05023579.hg.1	-0.7008368	5.844964	-6.284616	0.0001665	0.0357961	1.3389758	—	—
TC12001807.hg.1	1.0324698	6.155991	6.295270	0.0001681	0.0360393	1.3324964	BTG1	B-cell translocation gene 1, anti-proliferative
TC05001268.hg.1	1.0865740	6.860370	6.293774	0.0001688	0.0360695	1.3291031	LMBRD2	LMBR1 domain containing 2
TC0Y000233.hg.1	0.7946453	3.620691	6.266817	0.0001700	0.0362101	1.3194379	—	—
TC17001576.hg.1	-0.8785430	7.676467	-6.261897	0.0001709	0.0363075	1.3140286	UBTF	upstream binding transcription factor, RNA polymerase I
TC03001570.hg.1	0.8486447	5.953290	6.253220	0.0001727	0.0365646	1.3044802	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
TC01002618.hg.1	-0.6955727	6.098012	-6.241789	0.0001750	0.0368806	1.2918844	LRRC41	leucine rich repeat containing 41
TC0X000911.hg.1	0.8172135	7.308740	6.238632	0.0001756	0.0368806	1.2884016	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
TC05002612.hg.1	1.0116826	5.814343	6.252896	0.0001765	0.0368806	1.2861709	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporter), member 2
3676056_st	-0.8213548	9.883682	-6.235320	0.0001763	0.0368806	1.2847466	—	—
TC07001189.hg.1	0.8029068	3.645640	6.232071	0.0001769	0.0368806	1.2811601	LOC541472	uncharacterized LOC541472
TC06000062.hg.1	0.9248514	5.003055	6.233873	0.0001779	0.0368806	1.2770249	BMP6	bone morphogenetic protein 6
TC01004481.hg.1	-0.9095942	7.604041	-6.223675	0.0001787	0.0368806	1.2718833	TYW3	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
PSR04018328.hg.1	-0.6850819	10.037473	-6.218970	0.0001797	0.0368806	1.2666800	—	—
TC12001151.hg.1	-0.7251156	5.334659	-6.218364	0.0001798	0.0368806	1.2660096	CDCA3	cell division cycle associated 3
TC10002196.hg.1	0.8382532	5.115042	6.216382	0.0001802	0.0368806	1.2638168	FAS	Fas cell surface death receptor
TC07000971.hg.1	0.7457916	5.963063	6.215373	0.0001804	0.0368806	1.2627000	RNY5	RNA, Ro-associated Y5
TC10001678.hg.1	-1.0089253	8.255166	-6.215658	0.0001811	0.0368815	1.2596719	GFRA1	GDNF family receptor alpha 1
TC19002567.hg.1	1.0231707	6.404939	6.223767	0.0001815	0.0368815	1.2592386	ZNF600	zinc finger protein 600
TC0X000082.hg.1	1.0667003	4.389384	6.217546	0.0001885	0.0380366	1.2270153	REPS2	RALBP1 associated Eps domain containing 2
TC08002291.hg.1	0.9980822	7.132311	6.187975	0.0001875	0.0380022	1.2268893	RAB11FIP1	RAB11 family interacting protein 1 (class I)
TC17000489.hg.1	-0.9054424	6.997039	-6.176616	0.0001888	0.0380366	1.2196917	MSL1	male-specific lethal 1 homolog (Drosophila)
PSR17013142.hg.1	-0.7272154	10.114709	-6.162033	0.0001920	0.0384475	1.2034512	—	—
TC16001990.hg.1	0.7933195	6.338737	6.160572	0.0001924	0.0384475	1.2018216	—	—
TC09001287.hg.1	0.8115004	7.452340	6.160153	0.0001924	0.0384475	1.2013549	AGTPBP1	ATP/GTP binding protein 1
TC20001661.hg.1	-0.9626122	8.916224	-6.147048	0.0001954	0.0387897	1.1867280	AURKA	aurora kinase A
TC0X002243.hg.1	-0.8321752	9.012367	-6.145851	0.0001957	0.0387897	1.1853911	RBMX	RNA binding motif protein, X-linked
TC01001934.hg.1	-0.7688920	6.926028	-6.144893	0.0001959	0.0387897	1.1843198	COA6	cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
TC11002370.hg.1	0.7049578	5.339894	6.142997	0.0001964	0.0387897	1.1822015	USP2	ubiquitin specific peptidase 2
47419841_st	0.7774742	2.251890	6.131013	0.0001991	0.0391061	1.1687956	—	—
PSR17013957.hg.1	-0.7980797	7.108695	-6.130252	0.0001993	0.0391061	1.1679438	—	—
TC08000694.hg.1	0.7706608	3.938238	6.128964	0.0001996	0.0391061	1.1665016	COLEC10	collectin sub-family member 10 (C-type lectin)
TC12001393.hg.1	0.7497563	5.790322	6.125265	0.0002005	0.0391678	1.1623582	SLC2A13	solute carrier family 2 (facilitated glucose transporter), member 13
TC17000871.hg.1	0.8304286	8.961459	6.121046	0.0002015	0.0392253	1.1576296	RNU6-24P	RNA, U6 small nuclear 24, pseudogene
TC16000274.hg.1	1.2430994	4.701175	6.236831	0.0002062	0.0394451	1.1567211	—	—
TC09002901.hg.1	0.9086917	6.034552	6.118279	0.0002022	0.0392253	1.1545281	S1PR3	sphingosine-1-phosphate receptor 3
TC05003366.hg.1	-0.6496738	5.160606	-6.115480	0.0002028	0.0392253	1.1513878	PRR7-AS1	PRR7 antisense RNA 1
TC03000822.hg.1	0.8242307	4.334215	6.114659	0.0002030	0.0392253	1.1504668	MED12L	mediator complex subunit 12-like
TC08001112.hg.1	1.2655584	4.722894	6.252361	0.0002093	0.0397114	1.1470764	TEX15	testis expressed 15
TC0X001456.hg.1	-0.8305543	3.574283	-6.107504	0.0002047	0.0394451	1.1424349	MIR891A	microRNA 891a
TC17000461.hg.1	-0.9103936	7.285387	-6.104141	0.0002055	0.0394451	1.1386567	ARHGAP23	Rho GTPase activating protein 23
TC01005825.hg.1	0.8325480	4.532478	6.100671	0.0002064	0.0394451	1.1347577	—	—
TC04001517.hg.1	0.9823705	6.649955	6.099026	0.0002095	0.0397114	1.1221302	BBS7	Bardet-Biedl syndrome 7
PSR17014497.hg.1	-0.9326780	7.721961	-6.084883	0.0002103	0.0397114	1.1169896	—	—
TC12001106.hg.1	-1.0266070	8.247897	-6.093940	0.0002108	0.0397114	1.1164249	FOXM1	forkhead box M1
TC04001370.hg.1	0.8006393	6.508777	6.083081	0.0002107	0.0397114	1.1149591	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
TC02002486.hg.1	0.7276433	3.811756	6.079433	0.0002116	0.0397114	1.1108480	GRB14	growth factor receptor-bound protein 14
TC08000326.hg.1	0.6855006	5.751711	6.079065	0.0002117	0.0397114	1.1104326	POLB	polymerase (DNA directed), beta
3662446_st	-0.8649376	7.342181	-6.074257	0.0002129	0.0398319	1.1050102	—	—
TC03000624.hg.1	0.9148687	4.246080	6.079174	0.0002145	0.0400199	1.0998369	EAF2	ELL associated factor 2
TC04000649.hg.1	0.8563157	3.835277	6.046693	0.0002200	0.0408547	1.0738555	LOC101927184	uncharacterized LOC101927184
TC09000696.hg.1	-0.8407127	8.886267	-6.046170	0.0002201	0.0408547	1.0732634	SET	SET nuclear oncogene
TC01000704.hg.1	0.9002015	4.872713	6.048790	0.0002213	0.0408623	1.0692866	RNU6-414P	RNA, U6 small nuclear 414, pseudogene
TC06001769.hg.1	0.7877191	5.417000	6.041738	0.0002213	0.0408623	1.0682421	RP1-8B1.4	novel transcript
TC05002106.hg.1	-0.6597070	5.123380	-6.035185	0.0002230	0.0410102	1.0608128	PRR7-AS1	PRR7 antisense RNA 1
TC15000968.hg.1	-0.7421037	3.670053	-6.034154	0.0002233	0.0410102	1.0596436	—	—
TC04002614.hg.1	1.2310246	7.345271	6.100107	0.0002267	0.0414057	1.0584514	THAP9-AS1	THAP9 antisense RNA 1
TC06001401.hg.1	1.3278723	6.386365	6.174504	0.0002332	0.0418928	1.0470877	ZNF184	zinc finger protein 184
TC12000079.hg.1	-0.6924231	4.690483	-6.021563	0.0002267	0.0414057	1.0453492	—	—
TC15001667.hg.1	-0.7007874	6.435312	-6.018096	0.0002276	0.0414057	1.0414093	PTPN9	protein tyrosine phosphatase, non-receptor type 9
TC01001737.hg.1	0.6361299	3.521341	6.017371	0.0002278	0.0414057	1.0405841	CR2	complement component (3d/Epstein Barr virus) receptor 2
TC19002498.hg.1	-0.6631822	5.536909	-6.013727	0.0002288	0.0414788	1.0364410	—	—
TC06001770.hg.1	1.1146028	5.491472	6.070803	0.0002326	0.0418928	1.0325868	ENPP5	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
TC11002216.hg.1	-0.9927084	2.058663	-6.072525	0.0002352	0.0419061	1.0238336	—	—
PSR17008062.hg.1	-0.7636280	8.475421	-6.000612	0.0002324	0.0418928	1.0215096	—	—
TC17002878.hg.1	1.1441017	5.539993	6.069837	0.0002370	0.0419061	1.0173509	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
TC13000298.hg.1	0.6862483	5.336949	5.996814	0.0002335	0.0418928	1.0171810	SLAIN1	SLAIN motif family, member 1
TC04002294.hg.1	0.6944736	6.033319	5.992200	0.0002347	0.0419061	1.0119187	FNIP2	folliculin interacting protein 2
TC0X000872.hg.1	1.1458020	6.271831	6.051735	0.0002378	0.0419061	1.0114616	FANCB	Fanconi anemia, complementation group B
2839528_st	-0.6708871	9.942376	-5.986456	0.0002364	0.0419061	1.0053631	—	—
TC12001705.hg.1	0.9824956	4.996278	6.003356	0.0002381	0.0419061	1.0022851	CPM	carboxypeptidase M
TC05000664.hg.1	-0.7198809	6.342155	-5.983201	0.0002373	0.0419061	1.0016467	JADE2	jade family PHD finger 2
TC01002815.hg.1	0.9366845	4.854103	5.994392	0.0002383	0.0419061	1.0001637	TTLL7	tubulin tyrosine ligase-like family, member 7
TC08001864.hg.1	-0.8166237	7.625773	-5.976045	0.0002393	0.0419836	0.9934686	RBPMS	RNA binding protein with multiple splicing
TC20001764.hg.1	1.0085309	4.850182	5.997399	0.0002422	0.0421165	0.9874561	SEMG1	semenogelin I
TC03003341.hg.1	0.6506654	5.344237	5.966697	0.0002420	0.0421165	0.9827746	ACAD11	acyl-CoA dehydrogenase family, member 11
TC17001742.hg.1	0.8924477	4.427377	5.972074	0.0002425	0.0421165	0.9821332	RNU1-85P	RNA, U1 small nuclear 85, pseudogene
TC13001561.hg.1	0.7310357	1.964871	5.965433	0.0002424	0.0421165	0.9813275	—	—
TC04000274.hg.1	0.7614721	6.941056	5.962935	0.0002431	0.0421165	0.9784672	ATP10D	ATPase, class V, type 10D
TC19001806.hg.1	0.8584290	8.707050	5.961024	0.0002437	0.0421165	0.9762782	ZNF468	zinc finger protein 468
TC19001622.hg.1	1.0358584	6.488263	5.976327	0.0002459	0.0423960	0.9716116	—	—
TC17002449.hg.1	-0.8049097	5.773487	-5.949018	0.0002472	0.0425185	0.9625129	C17orf85	chromosome 17 open reading frame 85
TC04000770.hg.1	0.7820800	5.037378	5.946021	0.0002481	0.0425678	0.9590734	TRIM2	tripartite motif containing 2
TC05002340.hg.1	0.6543965	2.113583	5.940894	0.0002496	0.0426922	0.9531859	—	—
TC15000581.hg.1	0.7578253	7.170853	5.939545	0.0002500	0.0426922	0.9516367	RAB8B	RAB8B, member RAS oncogene family
TC0X002176.hg.1	-0.7970245	3.898798	-5.933606	0.0002518	0.0428939	0.9448103	—	—
TC08001820.hg.1	1.2661937	6.074054	6.051104	0.0002593	0.0437889	0.9412319	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)
TC08001310.hg.1	-0.7908201	6.326773	-5.918080	0.0002566	0.0435969	0.9269385	NCOA2	nuclear receptor coactivator 2
TC12002222.hg.1	1.5773198	6.116936	6.306658	0.0002790	0.0456462	0.9207704	LOC101930011	uncharacterized LOC101930011
TC02001943.hg.1	0.9692887	4.871403	5.930949	0.0002595	0.0437889	0.9198605	FBXO48	F-box protein 48
TC03002738.hg.1	0.7220029	4.918769	5.909128	0.0002593	0.0437889	0.9166178	LINC00884	long intergenic non-protein coding RNA 884
TC08000146.hg.1	-0.9703939	7.402207	-5.902010	0.0002637	0.0443793	0.9017439	SH2D4A	SH2 domain containing 4A
TC06000468.hg.1	-0.7361017	2.927344	-5.893378	0.0002643	0.0443793	0.8984288	—	—
47419787_st	0.9416209	1.549715	5.977919	0.0002708	0.0447256	0.8936239	—	—
PSR17008061.hg.1	-0.7481609	8.519221	-5.886910	0.0002664	0.0446164	0.8909474	—	—
TC0X000188.hg.1	-0.7015283	6.098042	-5.883072	0.0002676	0.0446164	0.8865054	—	—
TC05000458.hg.1	0.8468017	6.435274	5.881387	0.0002682	0.0446164	0.8845545	ARSK	arylsulfatase family, member K
TC02001350.hg.1	0.8908253	8.786863	5.881115	0.0002682	0.0446164	0.8842402	ACSL3	acyl-CoA synthetase long-chain family member 3
TC15000512.hg.1	0.9744678	3.722066	5.901910	0.0002712	0.0447256	0.8792569	—	—
TC07003253.hg.1	-0.6989955	4.894940	-5.875918	0.0002699	0.0447256	0.8782189	—	—
TC01000772.hg.1	-0.7667649	6.158237	-5.871326	0.0002714	0.0447256	0.8728968	TYW3	tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
TC03000584.hg.1	0.8214234	4.016183	5.864775	0.0002736	0.0449764	0.8652973	GRAMD1C	GRAM domain containing 1C
TC0X000424.hg.1	0.8653330	5.050930	5.863881	0.0002749	0.0450896	0.8612272	ATP7A	ATPase, Cu++ transporting, alpha polypeptide
TC07001559.hg.1	1.2321822	6.085074	5.961794	0.0002810	0.0457702	0.8610273	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
TC22001157.hg.1	-0.7633079	6.063562	-5.843693	0.0002807	0.0457702	0.8407949	—	—
TC08002303.hg.1	1.1008599	2.715276	5.931686	0.0002880	0.0462699	0.8360885	SFRP1	secreted frizzled-related protein 1
TC07002793.hg.1	0.9093050	4.942408	5.848419	0.0002831	0.0459984	0.8348157	—	—
TC6_mann_hap4000215.hg.1	0.7973964	7.264064	5.827657	0.0002862	0.0462699	0.8221116	MICA	MHC class I polypeptide-related sequence A
TC01000729.hg.1	0.7610375	6.233688	5.823919	0.0002875	0.0462699	0.8177513	DNAJC6	DnaJ (Hsp40) homolog, subfamily C, member 6
TC12000569.hg.1	-0.7142136	9.402261	-5.822761	0.0002879	0.0462699	0.8163989	XPOT	exportin, tRNA
TC04000663.hg.1	0.5891749	2.636117	5.822411	0.0002880	0.0462699	0.8159908	PCDH10	protocadherin 10
TC10000483.hg.1	-1.1992615	5.301807	-5.930473	0.0002954	0.0467168	0.8151643	KAT6B	K(lysine) acetyltransferase 6B
TC20000968.hg.1	-0.8720129	7.596638	-5.819551	0.0002890	0.0462892	0.8126520	AURKA	aurora kinase A
TC05001393.hg.1	0.7800498	4.579289	5.817474	0.0002898	0.0462892	0.8102268	ELOVL7	ELOVL fatty acid elongase 7
TC09002604.hg.1	0.8375740	5.407024	5.816467	0.0002901	0.0462892	0.8090510	NMRK1	nicotinamide riboside kinase 1
TC02002637.hg.1	1.1840209	5.894308	5.903156	0.0002977	0.0468905	0.8040834	STK17B	serine/threonine kinase 17b
TC07000998.hg.1	-1.0104979	7.923268	-5.822860	0.0002928	0.0465579	0.8029524	LRRC61	leucine rich repeat containing 61
3670232_st	-0.7862868	9.030261	-5.808005	0.0002931	0.0465579	0.7991596	—	—
TC06001123.hg.1	-0.7042154	5.476995	-5.804114	0.0002945	0.0466740	0.7946089	ARID1B	AT rich interactive domain 1B (SWI1-like)
TC07001611.hg.1	1.3951404	7.697125	5.967881	0.0003069	0.0475875	0.7910658	TFPI2	tissue factor pathway inhibitor 2
TC13001318.hg.1	-0.6949875	8.284446	-5.794805	0.0002979	0.0468905	0.7837102	TFDP1	transcription factor Dp-1
TC01000814.hg.1	1.0394062	2.906093	5.844574	0.0003058	0.0475875	0.7720152	WDR63	WD repeat domain 63
TC19000605.hg.1	-0.6192950	5.445699	-5.782740	0.0003023	0.0474361	0.7695642	CD177	CD177 molecule
TC08001286.hg.1	0.9124351	7.937853	5.781679	0.0003027	0.0474361	0.7683188	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1
TC15001553.hg.1	-0.9149346	6.346126	-5.786105	0.0003048	0.0475875	0.7636616	RBPMS2	RNA binding protein with multiple splicing 2
TC05001418.hg.1	0.7212330	3.191437	5.774718	0.0003053	0.0475875	0.7601455	MAST4-AS1	MAST4 antisense RNA 1
TC03000419.hg.1	0.7895432	5.672532	5.769964	0.0003070	0.0475875	0.7545599	MITF	microphthalmia-associated transcription factor
PSR12005973.hg.1	-0.6459052	10.811618	-5.768234	0.0003077	0.0475875	0.7525267	—	—
TC01005963.hg.1	0.7303854	7.295378	5.763599	0.0003094	0.0477534	0.7470756	—	—
TC05001289.hg.1	1.0192675	5.315255	5.784316	0.0003164	0.0484011	0.7332441	LIFR	leukemia inhibitory factor receptor alpha
TC01002892.hg.1	-0.7889750	6.297237	-5.751087	0.0003142	0.0483849	0.7323442	ALG14	ALG14, UDP-N-acetylglucosaminyltransferase subunit
TC05001355.hg.1	-0.5479133	2.169828	-5.749204	0.0003150	0.0483911	0.7301239	—	—
TC05002502.hg.1	0.8258399	3.479238	5.746992	0.0003158	0.0484011	0.7275165	GPR98	G protein-coupled receptor 98
TC10001701.hg.1	-0.6850589	6.968135	-5.740781	0.0003182	0.0485760	0.7201906	SFXN4	sideroflexin 4
TC04002094.hg.1	1.1892571	5.951618	5.835074	0.0003260	0.0491215	0.7188115	PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
3670218_st	-0.7220091	9.455152	-5.736700	0.0003198	0.0487144	0.7153737	—	—
TC20000582.hg.1	0.6486434	5.457538	5.730538	0.0003223	0.0488587	0.7080958	RNF24	ring finger protein 24
TC14001370.hg.1	0.7171635	5.988112	5.730464	0.0003223	0.0488587	0.7080080	STON2	stonin 2
TC06002224.hg.1	0.6783758	4.979017	5.729033	0.0003228	0.0488587	0.7063167	ULBP3	UL16 binding protein 3
47419910_st	0.5186503	1.133521	5.727172	0.0003236	0.0488656	0.7041169	—	—
TC19001199.hg.1	0.7629479	5.688917	5.719248	0.0003268	0.0491335	0.6947451	ZNF443	zinc finger protein 443
TC02004646.hg.1	-0.6580505	3.150427	-5.713796	0.0003290	0.0493589	0.6882904	—	—
TC6_cox_hap2000234.hg.1	0.7644801	7.361952	5.710209	0.0003304	0.0493672	0.6840419	MICA	MHC class I polypeptide-related sequence A
TC6_ssto_hap7000188.hg.1	0.7644801	7.361952	5.710209	0.0003304	0.0493672	0.6840419	MICA	MHC class I polypeptide-related sequence A

2. Generalized treatment responses: GO enrichment analysis

Gather a set of background genes to compare

library(genefilter)
library(Biobase)
#make a list of diff genes
diff.probe <- subset(x = diff.t)$probe
background.genes <- genefilter::genefinder(eset, as.character(diff.probe), method = "manhattan", scale = "none")
background.genes <- sapply(background.genes, function(x) x$indices)
background.genes <- as.vector(background.genes)
back.genes <- featureNames(project.bgcorrect.norm.avg)[background.genes]

Remove any differentially expressed genes from the background gene set and verify that it is correct: the diff set and the background set should have nothing in common.

back.genes <- setdiff(back.genes, diff.probe)
intersect(back.genes, diff.probe)

## character(0)

Examine mean intensity of the diff set, background set and all probes

library(cancerTiming)
fit.all <- topTable(fit, number = nrow(fit))
multidensity(list(
    all = fit.all[,"AveExpr"],
    fore = diff.t[,"AveExpr"],  
    back = fit.all[rownames(fit.all) %in% back.genes, "AveExpr"]),
  col = c("#e46981", "#ae7ee2", "#a7ad4a"),
  xlab = "mean expression",
  main = "GFR vs GF: Differentially Expressed, Background, and All gene expression levels"
)

Generalized treatment responses: GO pathway enrichment analysis

Is the differential expression set enriched in particular functional categories? This is why we have created a background gene set, so that we know the “typical” functional distribution of genes expressed at similar levels. We will connect the probe names to GO categories and run a few tests for pathway enrichment.

library(topGO)

gene.IDs <- rownames(eset)
in.universe <- gene.IDs %in% c(diff.probe,back.genes)
in.selection <- gene.IDs %in% diff.probe

all.genes <- in.selection[in.universe]
all.genes <- factor(as.integer(in.selection[in.universe]))
names(all.genes) <- gene.IDs[in.universe]

#this builds a database with all GO information related to our two test sets AND whether the gene is differentially expressed
top_GO_data <- new("topGOdata", ontology = "BP", allGenes = all.genes,
 nodeSize = 10, annot = annFUN.db, affyLib = "hta20transcriptcluster.db")

result_top_GO_elim <- 
  runTest(top_GO_data, algorithm = "elim", statistic = "Fisher")
result_top_GO_classic <- 
  runTest(top_GO_data, algorithm = "classic", statistic = "Fisher")

library(stringr)
res_top_GO <- GenTable(top_GO_data, Fisher.elim = result_top_GO_elim,
        Fisher.classic = result_top_GO_classic,
        orderBy = "Fisher.elim" , topNodes = 100)

genes_top_GO <- printGenes(top_GO_data, whichTerms = res_top_GO$GO.ID,
    chip = "hta20transcriptcluster.db", geneCutOff = 1000)

res_top_GO$sig_genes <- sapply(genes_top_GO, function(x){
                str_c(paste0(x[x$'raw p-value' == 2, "Symbol.id"],";"), 
                      collapse = "")
    })

res_top_GO <- res_top_GO[order(-res_top_GO$Significant / res_top_GO$Expected),]
kable(res_top_GO) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	GO.ID	Term	Annotated	Significant	Expected	Rank in Fisher.classic	Fisher.elim	Fisher.classic	sig_genes
1	GO:0001573	ganglioside metabolic process	10	8	1.29	1	2.5e-06	2.5e-06	NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
2	GO:0046466	membrane lipid catabolic process	10	8	1.29	2	2.5e-06	2.5e-06	NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
3	GO:0009311	oligosaccharide metabolic process	12	8	1.55	3	2.2e-05	2.2e-05	NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
4	GO:0006855	drug transmembrane transport	12	7	1.55	12	0.00025	0.00025	RGS4;RGS2;SLC19A2;ABCG2;ABCG2;SLC7A2;SLC25A30;
7	GO:0030104	water homeostasis	11	6	1.42	26	0.00115	0.00115	FLG;FLG;FLG;FLG;CLDN1;PRKAR2B;
17	GO:1990869	cellular response to chemokine	10	5	1.29	60	0.00500	0.00500	ROBO1;SLC12A2;DUSP1;SLC12A2;SLC12A2;
5	GO:0016052	carbohydrate catabolic process	19	9	2.45	13	0.00025	0.00025	NEU1;PGM2L1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
9	GO:0006977	DNA damage response, signal transduction…	15	7	1.93	30	0.00141	0.00141	CCNB1;CCNB1;SOX4;SOX4;TFDP1;AURKA;AURKA;
31	GO:0006119	oxidative phosphorylation	11	5	1.42	89	0.00821	0.00821	COA6;CCNB1;CCNB1;ATP7A;COQ7;
18	GO:0044106	cellular amine metabolic process	14	6	1.80	64	0.00531	0.00531	NR4A2;SAT1;ATP7A;SAT1;GDPD1;MIR21;
19	GO:0045824	negative regulation of innate immune res…	14	6	1.80	65	0.00531	0.00531	NMI;MICA;MIR21;MICA;MICA;MICA;
42	GO:0003197	endocardial cushion development	12	5	1.55	120	0.01262	0.01262	TGFBR2;ROBO1;ERBB3;ERBB3;JAG1;
43	GO:0019835	cytolysis	12	5	1.55	121	0.01262	0.01262	MICA;MMD;MICA;MICA;MICA;
23	GO:0042770	signal transduction in response to DNA d…	34	14	4.38	4	0.00637	3.2e-05	CCNB1;CCNB1;SOX4;SOX4;MYO6;RPS6KA6;FOXM1;TFDP1;PLK1;MIR21;PMAIP1;PMAIP1;AURKA;AURKA;
28	GO:0045471	response to ethanol	15	6	1.93	84	0.00790	0.00790	RGS4;RGS2;CLDN1;POLB;TP53INP1;EPS8;
29	GO:1902041	regulation of extrinsic apoptotic signal…	15	6	1.93	85	0.00790	0.00790	ATF3;SFRP1;FAS;THBS1;PMAIP1;PMAIP1;
93	GO:0007091	metaphase/anaphase transition of mitotic…	10	4	1.29	216	0.03014	0.03014	CCNB1;DUSP1;CCNB1;PLK1;
94	GO:0001556	oocyte maturation	10	4	1.29	217	0.03014	0.03014	CCNB1;CCNB1;AURKA;AURKA;
95	GO:0046626	regulation of insulin receptor signaling…	10	4	1.29	218	0.03014	0.03014	GRB14;ENPP1;SESN3;SESN3;
96	GO:0010039	response to iron ion	10	4	1.29	219	0.03014	0.03014	CCNB1;CCNB1;BMP6;ATP7A;
97	GO:0030858	positive regulation of epithelial cell d…	10	4	1.29	220	0.03014	0.03014	BMP6;BTG1;VDR;MIR21;
98	GO:0030071	regulation of mitotic metaphase/anaphase…	10	4	1.29	221	0.03014	0.03014	CCNB1;DUSP1;CCNB1;PLK1;
99	GO:0044784	metaphase/anaphase transition of cell cy…	10	4	1.29	222	0.03014	0.03014	CCNB1;DUSP1;CCNB1;PLK1;
100	GO:0050919	negative chemotaxis	10	4	1.29	223	0.03014	0.03014	ROBO1;EPHA7;SEMA3C;ITGB3;
6	GO:1901136	carbohydrate derivative catabolic proces…	28	11	3.61	18	0.00038	0.00038	PDE1A;HPSE;NT5E;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
8	GO:0051250	negative regulation of lymphocyte activa…	23	9	2.96	27	0.00137	0.00137	PELI1;BTN2A2;MICA;PAG1;SFRP1;MIR21;MICA;MICA;MICA;
16	GO:0045446	endothelial cell differentiation	18	7	2.32	59	0.00495	0.00495	CLDN1;BMP6;STC1;S1PR3;BTG1;MIR21;JAG1;
61	GO:0055021	regulation of cardiac muscle tissue grow…	13	5	1.68	151	0.01838	0.01838	RGS4;RGS2;TGFBR2;CCNB1;CCNB1;
40	GO:0032091	negative regulation of protein binding	16	6	2.06	115	0.01130	0.01130	MAP2;BAG2;IFIT1;SLPI;AURKA;AURKA;
25	GO:1905477	positive regulation of protein localizat…	19	7	2.45	77	0.00698	0.00698	ACSL3;PLS1;TFDP1;AKAP5;PTPN9;PMAIP1;PMAIP1;
26	GO:0055024	regulation of cardiac muscle tissue deve…	19	7	2.45	78	0.00698	0.00698	RGS4;RGS2;TGFBR2;CCNB1;CCNB1;ERBB3;ERBB3;
78	GO:0042271	susceptibility to natural killer cell me…	14	5	1.80	194	0.02564	0.02564	ULBP3;MICA;MICA;MICA;MICA;
79	GO:0060420	regulation of heart growth	14	5	1.80	195	0.02564	0.02564	RGS4;RGS2;TGFBR2;CCNB1;CCNB1;
80	GO:1903036	positive regulation of response to wound…	14	5	1.80	196	0.02564	0.02564	TGFBR2;HPSE;ATP7A;THBS1;MIR21;
81	GO:1901800	positive regulation of proteasomal prote…	14	5	1.80	197	0.02564	0.02564	BBS7;BAG2;PLK1;AURKA;AURKA;
53	GO:0043967	histone H4 acetylation	17	6	2.19	136	0.01561	0.01561	JADE2;JADE2;HCFC1;KAT6B;MSL1;SMARCB1;
54	GO:0070542	response to fatty acid	17	6	2.19	137	0.01561	0.01561	CLDN1;CCNB1;CCNB1;CTGF;SFRP1;GLDC;
35	GO:0048640	negative regulation of developmental gro…	20	7	2.58	97	0.00958	0.00958	RGS4;RGS2;MAP2;TGFBR2;EPHA7;SEMA3C;SFRP1;
30	GO:0021953	central nervous system neuron differenti…	24	8	3.09	87	0.00791	0.00791	MAP2;NR4A2;ROBO1;SOX4;SOX4;SFRP1;AGTPBP1;ATP7A;
14	GO:0008361	regulation of cell size	27	9	3.48	56	0.00490	0.00490	MAP2;FN1;SLC12A2;SLC12A2;SLC12A2;EPHA7;SEMA3C;ATP7A;CDH4;
15	GO:0009408	response to heat	27	9	3.48	57	0.00490	0.00490	IL1A;BAG2;MICA;TP53INP1;THBS1;CREBBP;MICA;MICA;MICA;
68	GO:1904659	glucose transmembrane transport	18	6	2.32	173	0.02094	0.02094	SLC25A27;ENPP1;SLC2A14;SLC2A3;SLC2A13;SLC2A3;
44	GO:0015698	inorganic anion transport	21	7	2.71	122	0.01283	0.01283	SLC12A2;SLC12A2;SLC12A2;ENPP1;CA2;SLC4A8;SLC25A30;
12	GO:0050770	regulation of axonogenesis	31	10	4.00	50	0.00399	0.00399	DAB1;MAP2;FN1;ROBO1;ZSWIM6;EPHA7;SEMA3C;PAK3;PAK3;CDH4;
37	GO:0007052	mitotic spindle organization	25	8	3.22	108	0.01036	0.01036	STAG1;CCNB1;CCNB1;EFHC1;EFHC1;PLK1;AURKA;AURKA;
86	GO:0008645	hexose transmembrane transport	19	6	2.45	206	0.02738	0.02738	SLC25A27;ENPP1;SLC2A14;SLC2A3;SLC2A13;SLC2A3;
87	GO:0015749	monosaccharide transmembrane transport	19	6	2.45	207	0.02738	0.02738	SLC25A27;ENPP1;SLC2A14;SLC2A3;SLC2A13;SLC2A3;
88	GO:0030101	natural killer cell activation	19	6	2.45	208	0.02738	0.02738	SLAMF7;ULBP3;MICA;MICA;MICA;MICA;
32	GO:0071901	negative regulation of protein serine/th…	29	9	3.74	90	0.00828	0.00828	RGS4;RGS2;PAQR3;DUSP1;PRKAR2B;PKIA;PKIA;SFRP1;PLK1;
47	GO:0042742	defense response to bacterium	26	8	3.35	126	0.01333	0.01333	SYT11;HIST1H2BI;MICA;SLPI;SEMG1;MICA;MICA;MICA;
71	GO:0008643	carbohydrate transport	23	7	2.96	177	0.02154	0.02154	PLS1;SLC25A27;ENPP1;SLC2A14;SLC2A3;SLC2A13;SLC2A3;
72	GO:0002228	natural killer cell mediated immunity	23	7	2.96	178	0.02154	0.02154	SLAMF7;ULBP3;MICA;KLRC2;MICA;MICA;MICA;
73	GO:0098739	import across plasma membrane	23	7	2.96	179	0.02154	0.02154	RGS4;RGS2;SLC12A2;SLC12A2;SLC12A2;SLC7A2;ATP1A3;
38	GO:0010389	regulation of G2/M transition of mitotic…	30	9	3.87	110	0.01052	0.01052	CCNB1;CCNB1;PRKAR2B;PKIA;PKIA;PLK1;MIR21;AURKA;AURKA;
58	GO:1902850	microtubule cytoskeleton organization in…	27	8	3.48	147	0.01688	0.01688	STAG1;CCNB1;CCNB1;EFHC1;EFHC1;PLK1;AURKA;AURKA;
59	GO:1901654	response to ketone	27	8	3.48	148	0.01688	0.01688	CLDN1;DUSP1;AHR;NCOA2;SFRP1;DCPS;ATP2B1;THBS1;
33	GO:0048771	tissue remodeling	34	10	4.38	91	0.00828	0.00828	SUCO;IL1A;MITF;SEMA3C;CA2;SFRP1;ATP7A;VDR;ITGB3;JAG1;
45	GO:0007088	regulation of mitotic nuclear division	31	9	4.00	124	0.01320	0.01320	IL1A;STAG1;CCNB1;DUSP1;CCNB1;CCNB2;PLK1;AURKA;AURKA;
46	GO:0048565	digestive tract development	31	9	4.00	125	0.01320	0.01320	DAB1;TGFBR2;BBS7;CCNB1;CCNB1;FOXF2;SFRP1;RBPMS2;VPS52;
24	GO:0000086	G2/M transition of mitotic cell cycle	38	11	4.90	75	0.00650	0.00650	CCNB1;CCNB1;PRKAR2B;PKIA;PKIA;FOXM1;CCNB2;PLK1;MIR21;AURKA;AURKA;
69	GO:0051224	negative regulation of protein transport	28	8	3.61	175	0.02106	0.02106	SYT11;FN1;BTN2A2;PKIA;RAB11FIP1;PKIA;RAB11FIP1;SFRP1;
70	GO:1904950	negative regulation of establishment of …	28	8	3.61	176	0.02106	0.02106	SYT11;FN1;BTN2A2;PKIA;RAB11FIP1;PKIA;RAB11FIP1;SFRP1;
55	GO:0007051	spindle organization	32	9	4.12	139	0.01634	0.01634	STAG1;CCNB1;CCNB1;EFHC1;EFHC1;PLK1;MAPRE2;AURKA;AURKA;
56	GO:0051783	regulation of nuclear division	32	9	4.12	140	0.01634	0.01634	IL1A;STAG1;CCNB1;DUSP1;CCNB1;CCNB2;PLK1;AURKA;AURKA;
57	GO:0030308	negative regulation of cell growth	32	9	4.12	141	0.01634	0.01634	RGS4;RGS2;MAP2;EAF2;ENPP1;EPHA7;SEMA3C;SFRP1;BTG1;
66	GO:0090150	establishment of protein localization to…	33	9	4.25	165	0.02000	0.02000	ACSL3;SGTB;SGTB;GRIP1;GRIP1;TFDP1;RAB8B;PMAIP1;PMAIP1;
67	GO:0098656	anion transmembrane transport	33	9	4.25	166	0.02000	0.02000	RGS4;RGS2;SLC12A2;SLC12A2;SLC12A2;SLC7A2;SLC4A8;SLC25A30;THBS1;
51	GO:0043409	negative regulation of MAPK cascade	37	10	4.77	134	0.01545	0.01545	RGS4;RGS2;ATF3;PAQR3;DUSP1;BTN2A2;SFRP1;RPS6KA6;FOXM1;MIR21;
52	GO:0005996	monosaccharide metabolic process	37	10	4.77	135	0.01545	0.01545	ATF3;NPY1R;ENPP1;NCOA2;PGM2L1;SLC2A3;SLC2A3;PMAIP1;PMAIP1;SOGA1;
76	GO:0055123	digestive system development	34	9	4.38	190	0.02422	0.02422	DAB1;TGFBR2;BBS7;CCNB1;CCNB1;FOXF2;SFRP1;RBPMS2;VPS52;
77	GO:0071456	cellular response to hypoxia	34	9	4.38	191	0.02422	0.02422	CCNB1;CCNB1;STC1;SFRP1;ATP7A;CREBBP;MIR21;PMAIP1;PMAIP1;
62	GO:0110053	regulation of actin filament organizatio…	38	10	4.90	152	0.01865	0.01865	RGS4;TMEFF2;CTGF;SFRP1;PAK3;PAK3;EPS8;TMOD2;TMOD2;MIR21;
63	GO:0098742	cell-cell adhesion via plasma-membrane a…	38	10	4.90	153	0.01865	0.01865	DAB1;TGFBR2;IL1RAP;ROBO1;CLDN1;PCDH10;CDH10;PCDH17;CD177;CDH4;
49	GO:0007162	negative regulation of cell adhesion	42	11	5.41	130	0.01439	0.01439	DAB1;PELI1;DUSP1;BTN2A2;PAG1;ACER2;ERBB3;ERBB3;THBS1;MIR21;JAG1;
21	GO:0043312	neutrophil degranulation	59	15	7.61	71	0.00615	0.00615	GCA;HPSE;NEU1;SLC2A3;SLC2A3;CRISPLD2;CD177;SLPI;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
41	GO:0051346	negative regulation of hydrolase activit…	52	13	6.70	118	0.01213	0.01213	RGS2;MAP2;SERPINI1;TIMP4;TFPI2;SH2D4A;RPS6KA3;IFIT1;SYTL2;SYTL2;THBS1;MIR21;SLPI;
10	GO:0006820	anion transport	72	18	9.28	46	0.00338	0.00338	RGS4;RGS2;SLC19A2;ACSL3;ATP10D;SLC12A2;SLC12A2;SLC12A2;ENPP1;CA2;STC1;NCOA2;SLC7A2;SLC4A8;SLC2A3;SLC2A3;SLC25A30;THBS1;
84	GO:0099003	vesicle-mediated transport in synapse	40	10	5.16	201	0.02646	0.02646	NA;SYT11;KIF5C;MAP2;AP3M2;GRIP1;GRIP1;TRIM9;STON2;ITGB3;
34	GO:0052548	regulation of endopeptidase activity	61	15	7.86	92	0.00853	0.00853	SERPINI1;TIMP4;ROBO1;EPHA7;CTGF;TFPI2;ACER2;RPS6KA3;FAS;THBS1;MIR21;PMAIP1;PMAIP1;SLPI;SEMG1;
48	GO:0015711	organic anion transport	53	13	6.83	129	0.01426	0.01426	RGS4;RGS2;SLC19A2;ACSL3;ATP10D;CA2;NCOA2;SLC7A2;SLC4A8;SLC2A3;SLC2A3;SLC25A30;THBS1;
75	GO:0062012	regulation of small molecule metabolic p…	45	11	5.80	189	0.02395	0.02395	CCNB1;CCNB1;BMP6;ENPP1;NCOA2;ATP7A;VDR;MIR21;PMAIP1;PMAIP1;SOGA1;
50	GO:0042493	response to drug	141	34	18.17	6	0.01511	0.00012	SYT11;RGS4;RGS2;SLC19A2;MTR;DAB1;NR4A2;TGFBR2;TIMP4;CLDN1;ABCG2;ABCG2;CCNB1;DUSP1;CCNB1;MYO6;AHR;PRKAR2B;ZNF277;SEMA3C;POLB;CA2;NCOA2;TP53INP1;SLC7A2;SFRP1;ACER2;DCPS;EPS8;SLC25A30;THBS1;COQ7;MIR21;JAG1;
11	GO:0051051	negative regulation of transport	84	20	10.83	48	0.00379	0.00379	SYT11;RGS4;RGS2;FN1;BTN2A2;ENPP1;PKIA;STC1;RAB11FIP1;GEM;PKIA;RAB11FIP1;SFRP1;ATP7A;ERBB3;ERBB3;TRIM9;THBS1;ITGB3;SEMG1;
64	GO:0015672	monovalent inorganic cation transport	55	13	7.09	157	0.01936	0.01936	RGS4;SCN9A;SCN9A;SLC12A2;SLC12A2;SLC12A2;SLC25A27;KCNV1;ATP7A;SLC4A8;SLC2A13;MIR21;ATP1A3;
90	GO:0007568	aging	52	12	6.70	212	0.02893	0.02893	TGFBR2;CLDN1;SLC12A2;SLC12A2;SLC12A2;CTGF;ZNF277;POLB;FOXM1;ATP2B1;COQ7;MIR21;
65	GO:0045862	positive regulation of proteolysis	61	14	7.86	164	0.01995	0.01995	FN1;ROBO1;BBS7;BAG2;CTGF;ACER2;FAS;PLK1;MIR21;PMAIP1;PMAIP1;AURKA;AURKA;SEMG1;
74	GO:0051271	negative regulation of cellular componen…	62	14	7.99	183	0.02286	0.02286	TMEFF2;MITF;ROBO1;DUSP1;SEMA3C;STC1;TP53INP1;EPPK1;SFRP1;NAV3;THBS1;MIR21;JAG1;SEMG1;
13	GO:0009611	response to wounding	102	23	13.15	52	0.00411	0.00411	SYT11;MTR;IL1A;TMEFF2;FN1;TGFBR2;HPSE;CCNB1;CCNB1;CTGF;PRKAR2B;TFPI2;EPPK1;ATP7A;DGKA;ERBB3;ERBB3;THBS1;MIR21;ITGB3;CD177;AURKA;AURKA;
91	GO:2000146	negative regulation of cell motility	58	13	7.48	214	0.02945	0.02945	TMEFF2;MITF;ROBO1;DUSP1;STC1;TP53INP1;EPPK1;SFRP1;NAV3;THBS1;MIR21;JAG1;SEMG1;
82	GO:0040013	negative regulation of locomotion	63	14	8.12	198	0.02608	0.02608	TMEFF2;MITF;ROBO1;DUSP1;SEMA3C;STC1;TP53INP1;EPPK1;SFRP1;NAV3;THBS1;MIR21;JAG1;SEMG1;
83	GO:0001101	response to acid chemical	63	14	8.12	199	0.02608	0.02608	CLDN1;CCNB1;DUSP1;CCNB1;BMP6;CTGF;LANCL2;GDAP1;SFRP1;GLDC;ACER2;ATP7A;SESN3;SESN3;
92	GO:0031346	positive regulation of cell projection o…	70	15	9.02	215	0.02952	0.02952	RGS2;FN1;SERPINI1;ROBO1;CUX1;ATP7A;PAK3;PAK3;NAV3;EPS8;GRIP1;GRIP1;RAB8B;MIR21;CDH4;
39	GO:0006952	defense response	216	43	27.84	36	0.01084	0.00151	SYT11;SLAMF7;CR2;TSPAN2;PELI1;IL1A;NMI;SCN9A;FN1;SCN9A;IL1RAP;CLDN1;NFKBIZ;BMP6;HIST1H2BI;NT5E;ULBP3;MICA;HLA-DQB1;POLB;COLEC10;SLC7A2;S1PR3;PAK3;RPS6KA3;PAK3;IFIT1;MUC15;KLRC3;KLRC2;THBS1;CREBBP;MIR21;NCBP3;PMAIP1;PMAIP1;CREB3L3;CD177;SLPI;SEMG1;MICA;MICA;MICA;
22	GO:0014070	response to organic cyclic compound	161	32	20.75	73	0.00634	0.00634	RGS4;ACSL3;PELI1;NR4A2;TGFBR2;CLDN1;CCNB1;DUSP1;CCNB1;BMP6;CTGF;AHR;PRKAR2B;GDAP1;CA2;STC1;NCOA2;SFRP1;GLDC;PAK3;HCFC1;PAK3;IFIT1;GRIP1;ATP2B1;VDR;GRIP1;THBS1;MIR21;PMAIP1;PMAIP1;ATP1A3;
85	GO:0006812	cation transport	132	25	17.01	202	0.02698	0.02698	SYT11;RGS4;RGS2;CACNB4;SCN9A;SCN9A;ATP10D;SLC12A2;SLC12A2;SLC12A2;SLC25A27;CTGF;TSPAN13;STC1;GEM;KCNV1;SLC7A2;ATP7A;SLC4A8;SLC2A13;ATP2B1;VDR;MIR21;ATP1A3;SEMG1;
36	GO:1901565	organonitrogen compound catabolic proces…	185	35	23.85	99	0.00978	0.00978	PDCL3;PELI1;FBXO48;PDE1A;TIMP4;TRIM2;HPSE;BBS7;CCNB1;SGTB;CCNB1;SGTB;BAG2;NT5E;NEU1;GLDC;SAT1;SAT1;USP2;AMN1;TRIM9;PLK1;SCPEP1;MIR21;PMAIP1;PMAIP1;AURKA;AURKA;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
60	GO:1901700	response to oxygen-containing compound	251	47	32.35	47	0.01829	0.00345	RGS4;RGS2;MTR;PELI1;NR4A2;GRB14;TGFBR2;TIMP4;CLDN1;CCNB1;DUSP1;CCNB1;BMP6;SOX4;ENPP1;CTGF;SOX4;AHR;LANCL2;PRKAR2B;ZNF277;POLB;GDAP1;CA2;STC1;NCOA2;TP53INP1;SFRP1;GLDC;ACER2;ATP7A;RPS6KA3;DCPS;SESN3;SESN3;EPS8;ATP2B1;BTG1;VDR;THBS1;RAB8B;MIR21;ATP1A3;JAG1;SOGA1;SLPI;SMARCB1;
20	GO:0042127	regulation of cell proliferation	270	49	34.80	66	0.00546	0.00546	ATF3;TNFRSF9;PDCL3;PELI1;IL1A;FN1;PDE1A;TGFBR2;MITF;EAF2;ROBO1;HPSE;CCNB1;LIFR;DUSP1;CCNB1;BMP6;SOX4;BTN2A2;SLC25A27;CTGF;SOX4;AHR;TES;CDCA7L;TNS3;TP53INP1;EPPK1;SFRP1;ACER2;S1PR3;GRPR;SAT1;ATP7A;SAT1;FOXM1;STYK1;BTG1;ERBB3;VDR;ERBB3;TFDP1;THBS1;CCNB2;RBPMS2;MIR21;ITGB3;JAG1;SMARCB1;
89	GO:0051094	positive regulation of developmental pro…	219	38	28.23	211	0.02822	0.02822	SUCO;RGS2;DAB1;PDCL3;IL1A;FN1;TGFBR2;PLS1;SERPINI1;IL1RAP;ROBO1;NFKBIZ;HPSE;CCNB1;CCNB1;BMP6;BTN2A2;CTGF;SEMA3C;CUX1;CA2;SFRP1;PAK3;RPS6KA3;PAK3;GRIP1;BTG1;ERBB3;VDR;GRIP1;ERBB3;THBS1;MIR21;MMD;CDH4;JAG1;AURKA;AURKA;
27	GO:0009605	response to external stimulus	362	62	46.66	79	0.00706	0.00706	SYT11;CR2;ATF3;DAB1;B3GNT2;KIF5C;ACSL3;PELI1;NR4A2;TGFBR2;TIMP4;ROBO1;CLDN1;NFKBIZ;CDS1;USP53;HPSE;ZSWIM6;CCNB1;SLC12A2;DUSP1;CCNB1;SLC12A2;SLC12A2;BMP6;HIST1H2BI;NT5E;ELOVL4;EPHA7;MICA;SEMA3C;DOCK4;GDAP1;COLEC10;STC1;EPPK1;SLC7A2;SFRP1;GRPR;RPS6KA3;IFIT1;GFRA1;FAS;GFRA1;SESN3;USP2;SESN3;ATP2B1;VDR;THBS1;MIR21;NCBP3;ITGB3;PMAIP1;PMAIP1;CREB3L3;CDH4;SLPI;SEMG1;MICA;MICA;MICA;

write.csv(res_top_GO, "nested_interactions/DE.genes.treatment.GO.pathway.enrichment.csv")

This is a ranking of which GO terms are enriched according to two different testing strategies, elim and Fisher.classic. these are, roughly, probability scores and can be broadly interpreted the same way as p-scores.

Generalized treatment responses: Visualizing the GO results:

nodes <- showSigOfNodes(top_GO_data, score(result_top_GO_elim), firstSigNodes = 3,
               useInfo = 'def')

png("nested_interactions/DE.genes.treatment.GO.pathway.enrichment.nodes.png")
nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 28 
## Number of Edges = 45 
## 
## $complete.dag
## [1] "A graph with 28 nodes."

dev.off()

## png 
##   2

nodes

## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 28 
## Number of Edges = 45 
## 
## $complete.dag
## [1] "A graph with 28 nodes."

3. Generalized treatment responses: Pathway enrichment analysis via Reactome

map DE genes to Entrez, then reactome pathways, and perform pathway enrichment:

library(reactome.db)
library(DOSE)
library(ReactomePA)
entrez_ids <- mapIds(hta20transcriptcluster.db, 
      keys = rownames(eset), 
      keytype = "PROBEID",
      column = "ENTREZID",
      multiVals = "first")

reactome_enrich <- enrichPathway(gene = entrez_ids[diff.probe], 
                                universe = entrez_ids[c(diff.probe, 
                                                        back.genes)],
                                organism = "human",
                                pvalueCutoff = 0.05, pAdjustMethod = "none",
                                qvalueCutoff = 1, 
                                readable = TRUE)

reactome_enrich@result$Description <- paste0(str_sub(
                                    reactome_enrich@result$Description, 1, 20),
                                    "...")

write.csv(as.data.frame(reactome_enrich), "nested_interactions/DE.genes.treatment.pathway.enrichment.png")

kable(reactome_enrich) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")

	ID	Description	GeneRatio	BgRatio	pvalue	p.adjust	qvalue	geneID	Count
R-HSA-2565942	R-HSA-2565942	Regulation of PLK1 A…	5/173	13/1297	0.0208502	0.0208502	0.9676664	PLK1/CCNB1/CCNB2/PRKAR2B/AURKA	5
R-HSA-196849	R-HSA-196849	Metabolism of water-…	6/173	18/1297	0.0240751	0.0240751	0.9676664	SLC2A3/NT5E/ENPP1/SLC19A2/MTR/NMRK1	6
R-HSA-3214847	R-HSA-3214847	HATs acetylate histo…	7/173	25/1297	0.0390089	0.0390089	0.9676664	JADE2/HCFC1/CREBBP/HIST1H2BI/MSL1/NCOA2/KAT6B	7

Generalized treatment responses: Visualizing reactome results

Barplots, showing reaction categories represented and their respective p-values:

png("nested_interactions/DE.genes.treatment.reactome.pathway.enrichment.barplot.png")
barplot(reactome_enrich)
dev.off()

## png 
##   2

barplot(reactome_enrich)

png("nested_interactions/DE.genes.treatment.reactome.pathway.enrichment.emapplot.png")
emapplot(reactome_enrich, showCategory = 20)
dev.off()

## png 
##   2

emapplot(reactome_enrich, showCategory = 20)

In this plot, color is p-value, size is proportional to the number of DE genes that mapped to the pathway, and the edge thickness is proportional to the number of shared genes between the units. This is useful for examining the interdependence of the pathways; which results should be taken more serioiusly, are independent? This particular plot shows the top ten most significant pathways, regardless of their p-values