Differential Gene Expressionand Pathway Enrichment: tGF vs. cGF

Pipeline overview

This script performs pairwise testing for gene-expression results via Affymetrix gene chip, visualizes the results, places the differentially-expressed genes into pathways via GO and Reactome, and performs pathway enrichment analyses.

Sources: The second half of this script (pathway enrichment ) draws from https://bioconductor.org/packages/devel/workflows/vignettes/maEndToEnd/inst/doc/MA-Workflow.html

Preparation for adaptation to a different pairwise comparison within the project

You should already have prepared test matrix files according to limma protocols

  1. The strings “tGF.cGF” and “tGF vs. cGF” are used throughout the script to denote the test being performed. These should be bulk find-and-replaced throughout the script
  2. The “targets” matrix in section “3. Set up test matrices” must be changed to the appropriate test
  3. Sections “5. Load in the metadata” and “6. Set up the test” must be customized to the desired test
  4. In Section 8. chance the “coef=” to the appropriate category

Results files;

1. Prepare the base environment

2. Prepare Annotation Table to yield useful mappings of probe to gene

Annotation <- read.csv("HTA-2_0.na35.2.hg19.transcript.csv/HTA-2_0.na35.2.hg19.transcript.csv", header=TRUE, skip=19)
probe.gene.map <- read.csv("probe.gene.map.csv")

3. Set up test matrices

Differential abundance can only be performed on pairs of sample sets. Each pairwise test has to be configured as a separate file. Importing the test matrices:

targets <- read.csv("targets.GFonly.txt", as.is=T)

all of the samples and metadata are listed here:

targets 
##                                      FileName Strain Treatment Experiment
## 1   20160505_HTA2.0_0316_WTH_1R_(HTA-2_0).CEL     GF   control          1
## 2   20160505_HTA2.0_0317_WTH_2R_(HTA-2_0).CEL     GF      drug          1
## 3 20160616_HTA2.0_0333_WTH_1_R1_(HTA-2_0).CEL     GF   control          2
## 4 20160616_HTA2.0_0334_WTH_2_R1_(HTA-2_0).CEL     GF      drug          2

4. Define the subset of .CEL files, read them in, and normalize them

dat <- read.celfiles(targets$FileName)
## Reading in : 20160505_HTA2.0_0316_WTH_1R_(HTA-2_0).CEL
## Reading in : 20160505_HTA2.0_0317_WTH_2R_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0333_WTH_1_R1_(HTA-2_0).CEL
## Reading in : 20160616_HTA2.0_0334_WTH_2_R1_(HTA-2_0).CEL
project.bgcorrect.norm.avg <- rma(dat, background=TRUE, normalize=TRUE)
## Background correcting
## Normalizing
## Calculating Expression
project.bgcorrect.norm.avg.filt <- exprs(project.bgcorrect.norm.avg)[which(rownames(project.bgcorrect.norm.avg) %in% Annotation[,1]),]

5. Load in the metadata

Exp <- factor(targets$Experiment)
Strain <- factor(targets$Strain, levels=c("GF","GFR"))
Treatment <- factor(targets$Treatment, levels=c("control","drug"))

6. Define the test

This is important decision; these chips were ran from different experimental batches, thus I have controlled for experiment, essentially running a paired analysis. In an earlier iteration, I did not control for experiment and found very few differences due to the high variance between experimental replicates

design <- model.matrix(~Exp+Treatment)

7. Run “fit” algorithms and separate out the significantly different probes

eset <- project.bgcorrect.norm.avg.filt
fit <- lmFit(eset, design)
fit <- eBayes(fit, trend=T, robust=T)
## Warning: 82 very small variances detected, have been offset away from zero
results <- decideTests(fit, p.value = 0.05, method = "separate", adjust.method = "fdr")
write.table(summary(results), "pairwise_test_results/tGF.cGF/summary.tGF.cGF.csv", quote=F)

This is a simple summary of the differences, only the far right column

summary(results)
##        (Intercept)  Exp2 Treatmentdrug
## Down             0    52           354
## NotSig          84 70270         69527
## Up           70439   201           642

8. Generate tables of the differentially expressed genes and attach gene name/function information

This script also generates a temporary differential expression table for ALL probes which can be used later for comparisons with other pairwise-test results

library(data.table)
library(dplyr)
#full table
fit.tGF.cGF <- topTable(fit, n = nrow(fit))
#diff table only, must be customized based on summary results
diff <- topTable(fit, p.value = 0.05,  n = Inf, coef="Treatmentdrug")
setDT(diff, keep.rownames = TRUE)[]
colnames(diff)[1] <- "probe"
diff <- dplyr::left_join(diff,probe.gene.map,by="probe")
## Warning: Column `probe` joining character vector and factor, coercing into
## character vector
write.table(diff, "pairwise_test_results/tGF.cGF/diff.tGF.cGF", quote = F)
write.table(diff$name, "pairwise_test_results/tGF.cGF/diff.tGF.cGF.gene.list", quote = F)
kable(diff) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")
probe logFC AveExpr t P.Value adj.P.Val B name description
TC01005830.hg.1 2.3585666 4.780776 17.804118 0.0000000 0.0012271 8.5286610 FLG filaggrin
TC06002615.hg.1 2.3109740 4.613586 15.927529 0.0000001 0.0012271 7.9038618 SOX4 SRY (sex determining region Y)-box 4
TC08002280.hg.1 2.1631742 4.123272 15.921472 0.0000001 0.0012271 7.9016402 — —
TC11003279.hg.1 2.0773213 4.848495 15.309617 0.0000001 0.0012271 7.6697078 SYTL2 synaptotagmin-like 2
TC01005829.hg.1 2.0995817 5.733445 15.056257 0.0000001 0.0012271 7.5691285 FLG filaggrin
47424360_st -3.4200134 3.161489 -19.521044 0.0000001 0.0012271 7.4982561 — —
TC0X001624.hg.1 1.8038748 8.308845 14.803925 0.0000001 0.0012271 7.4661837 SAT1 spermidine/spermine N1-acetyltransferase 1
TC01005828.hg.1 1.8760731 6.247690 14.727581 0.0000001 0.0012271 7.4344777 FLG filaggrin
TC06001902.hg.1 2.0420860 5.022374 14.507516 0.0000002 0.0012271 7.3415938 ELOVL4 ELOVL fatty acid elongase 4
TC20000876.hg.1 1.8558444 7.018695 14.324119 0.0000002 0.0012271 7.2624601 SLPI secretory leukocyte peptidase inhibitor
TC11002205.hg.1 1.8116107 5.813469 14.214422 0.0000002 0.0012271 7.2143595 SESN3 sestrin 3
TC05000084.hg.1 1.9104125 3.917529 14.128940 0.0000002 0.0012271 7.1764716 FAM105A family with sequence similarity 105, member A
TC08001062.hg.1 1.8387860 4.182372 13.556656 0.0000003 0.0013170 6.9133626 STC1 stanniocalcin 1
TC02001238.hg.1 2.0801281 4.744114 13.634140 0.0000003 0.0013170 6.9051976 MAP2 microtubule-associated protein 2
TC02000927.hg.1 1.7636937 5.119798 13.452586 0.0000003 0.0013170 6.8636856 KIF5C kinesin family member 5C
TC05001641.hg.1 1.8026916 3.668985 13.375908 0.0000003 0.0013170 6.8267114 SLCO4C1 solute carrier organic anion transporter family, member 4C1
TC01002163.hg.1 1.8621155 5.236414 13.316455 0.0000003 0.0013170 6.7978226 TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TC13000634.hg.1 1.7374540 5.212456 13.287701 0.0000004 0.0013170 6.7837814 SLC25A30 solute carrier family 25, member 30
TC08001988.hg.1 1.7558348 5.592345 13.274774 0.0000004 0.0013170 6.7774541 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
47424061_st -1.5085819 2.177214 -13.199365 0.0000004 0.0013170 6.7403588 — —
TC11002081.hg.1 1.7939923 4.779255 12.997425 0.0000004 0.0013258 6.6394508 PGM2L1 phosphoglucomutase 2-like 1
TC20001333.hg.1 -1.6434615 6.046572 -12.974343 0.0000004 0.0013258 6.6277692 — —
TC01003245.hg.1 1.9526026 6.223859 13.286926 0.0000004 0.0013258 6.6048643 FLG filaggrin
TC02001101.hg.1 1.5665874 6.831020 12.610458 0.0000006 0.0016180 6.4394959 FAM171B family with sequence similarity 171, member B
TC02002499.hg.1 1.7081966 3.471731 12.491788 0.0000006 0.0016829 6.3763834 SCN9A sodium channel, voltage-gated, type IX, alpha subunit
TC12002256.hg.1 1.5633745 6.631446 12.415539 0.0000006 0.0017044 6.3353760 — —
TC04002753.hg.1 1.5477578 5.768439 12.087722 0.0000008 0.0018274 6.1549075 CLGN calmegin
TC6_cox_hap2000143.hg.1 1.5030121 6.483575 12.005750 0.0000008 0.0018274 6.1087000 IER3 immediate early response 3
TC6_dbb_hap3000132.hg.1 1.5030121 6.483575 12.005750 0.0000008 0.0018274 6.1087000 IER3 immediate early response 3
TC6_mann_hap4000121.hg.1 1.5030121 6.483575 12.005750 0.0000008 0.0018274 6.1087000 IER3 immediate early response 3
TC6_ssto_hap7000123.hg.1 1.5030121 6.483575 12.005750 0.0000008 0.0018274 6.1087000 IER3 immediate early response 3
TC18000564.hg.1 1.7399870 5.062335 11.965659 0.0000009 0.0018274 6.0859399 DSEL dermatan sulfate epimerase-like
TC02002628.hg.1 1.5813303 3.860705 11.906668 0.0000009 0.0018274 6.0522567 TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2
TC08001361.hg.1 1.6819262 5.589945 11.862686 0.0000009 0.0018274 6.0269920 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
TC12002778.hg.1 1.5935818 4.318916 11.860149 0.0000009 0.0018274 6.0255309 MGP matrix Gla protein
TC0X000112.hg.1 1.5001454 6.103617 11.848438 0.0000009 0.0018274 6.0187801 SAT1 spermidine/spermine N1-acetyltransferase 1
TC12002734.hg.1 1.3941863 9.873849 11.751730 0.0000010 0.0018696 5.9626773 SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TC04002616.hg.1 1.8666303 3.867494 12.052606 0.0000010 0.0018696 5.9370383 — —
TC0X000948.hg.1 1.5300655 5.278410 11.704658 0.0000010 0.0018696 5.9351389 TMEM47 transmembrane protein 47
TC06002062.hg.1 1.5012447 5.519194 11.631709 0.0000011 0.0019214 5.8921613 MAN1A1 mannosidase, alpha, class 1A, member 1
TC07000111.hg.1 1.4459902 7.080392 11.553753 0.0000012 0.0019836 5.8458253 TSPAN13 tetraspanin 13
TC12001170.hg.1 1.3561466 8.711011 11.397103 0.0000013 0.0021687 5.7514202 SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TC17000720.hg.1 1.4994818 4.977655 11.364156 0.0000013 0.0021687 5.7313415 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1
TC02002747.hg.1 1.4400900 5.879644 11.332819 0.0000014 0.0021687 5.7121720 FN1 fibronectin 1
TC19002526.hg.1 1.4784393 5.181348 11.305613 0.0000014 0.0021687 5.6954711 — —
TC18000610.hg.1 1.4959294 5.188536 11.255600 0.0000014 0.0022019 5.6646302 — —
TC16000258.hg.1 -1.3148308 8.949581 -11.153960 0.0000015 0.0023252 5.6013869 PLK1 polo-like kinase 1
TC12002552.hg.1 1.7291533 5.586519 11.354895 0.0000017 0.0024570 5.5067181 — —
TC06002990.hg.1 -1.3792417 6.884828 -10.992667 0.0000018 0.0024690 5.4994450 GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa
TC12000182.hg.1 1.4335149 6.375921 10.869818 0.0000019 0.0026076 5.4204760 GPRC5A G protein-coupled receptor, class C, group 5, member A
TC08001612.hg.1 -2.3465551 3.784128 -12.934729 0.0000017 0.0024570 5.4155047 — —
TC06003084.hg.1 1.5968342 9.009437 11.381657 0.0000019 0.0026076 5.4124397 TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TC07002501.hg.1 -1.3612603 6.225083 -10.798261 0.0000020 0.0026093 5.3739413 CUX1 cut-like homeobox 1
TC01000745.hg.1 1.7090529 8.471756 11.493698 0.0000020 0.0026093 5.3537512 GADD45A growth arrest and DNA-damage-inducible, alpha
TC05000262.hg.1 1.3442519 7.147076 10.760397 0.0000021 0.0026346 5.3491556 ZSWIM6 zinc finger, SWIM-type containing 6
TC12001282.hg.1 1.8556019 5.315932 11.478362 0.0000020 0.0026093 5.3451070 EPS8 epidermal growth factor receptor pathway substrate 8
47420725_st -1.3557761 2.417068 -10.721676 0.0000022 0.0026673 5.3236922 — —
TC18000674.hg.1 1.3037562 7.937280 10.615247 0.0000023 0.0028484 5.2530910 — —
TC6_qbl_hap6000133.hg.1 1.4161565 6.481972 10.510845 0.0000025 0.0030399 5.1829509 IER3 immediate early response 3
TC04001589.hg.1 1.3623999 5.241676 10.440012 0.0000027 0.0031620 5.1348571 CLGN calmegin
TC07001611.hg.1 1.3530455 7.153714 10.418269 0.0000027 0.0031644 5.1200121 TFPI2 tissue factor pathway inhibitor 2
3676043_st -1.2829071 8.869132 -10.355143 0.0000029 0.0032744 5.0766894 — —
TC07003064.hg.1 1.3225313 8.084958 10.270321 0.0000031 0.0034497 5.0179534 TFPI2 tissue factor pathway inhibitor 2
TC05003028.hg.1 1.3234164 5.259048 10.136506 0.0000034 0.0037852 4.9240522 — —
TC12002858.hg.1 1.2839280 5.933975 10.079530 0.0000036 0.0038007 4.8836048 VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
TC07000810.hg.1 1.8433487 6.246602 11.157884 0.0000035 0.0037978 4.8797413 CPA4 carboxypeptidase A4
TC19000439.hg.1 -1.3690234 6.660306 -10.063326 0.0000036 0.0038007 4.8720502 KCTD15 potassium channel tetramerization domain containing 15
TC07000999.hg.1 -1.3636093 7.963591 -10.044836 0.0000037 0.0038007 4.8588373 ZBED6CL ZBED6 C-terminal like
TC04000462.hg.1 1.2985303 6.012808 10.039654 0.0000037 0.0038007 4.8551295 CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
3676041_st -1.1631640 8.943373 -10.009666 0.0000038 0.0038401 4.8336227 — —
TC01001306.hg.1 1.3055667 3.276795 9.987687 0.0000039 0.0038553 4.8178101 SYT11 synaptotagmin XI
TC05001411.hg.1 1.2276782 6.477901 9.815025 0.0000045 0.0038696 4.6921004 SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
47421298_st -1.1030246 1.970200 -9.805949 0.0000045 0.0038696 4.6854184 — —
TC11003298.hg.1 2.5023031 6.317955 12.909164 0.0000041 0.0038696 4.6447884 SESN3 sestrin 3
TC07001873.hg.1 1.4418017 5.081390 9.736116 0.0000048 0.0038696 4.6337570 MKLN1-AS MKLN1 antisense RNA
TC12001208.hg.1 -1.2270328 6.805837 -9.716557 0.0000049 0.0038696 4.6192082 CLEC2B C-type lectin domain family 2, member B
TC19000688.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A1 small ILF3/NF90-associated RNA A1
TC19000689.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19000691.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A1 small ILF3/NF90-associated RNA A1
TC19001731.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001732.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001733.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001734.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001735.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001736.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001737.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001738.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC19001739.hg.1 1.3015379 7.933630 9.712917 0.0000049 0.0038696 4.6164970 SNAR-A3 small ILF3/NF90-associated RNA A3
TC02004676.hg.1 2.0304212 4.752040 11.185021 0.0000047 0.0038696 4.6096804 SCN9A sodium channel, voltage-gated, type IX, alpha subunit
47422282_st -1.0555930 1.410995 -9.694916 0.0000050 0.0038853 4.6030691 — —
3671548_st -1.4759132 4.212463 -9.695797 0.0000051 0.0039251 4.5796658 — —
TC12001907.hg.1 1.3550207 5.697815 9.657009 0.0000051 0.0039251 4.5746962 — —
TC03000768.hg.1 1.7193198 6.236189 10.510369 0.0000052 0.0039318 4.5546444 PLS1 plastin 1
3676060_st -1.1991995 7.332052 -9.560130 0.0000056 0.0041728 4.5015791 — —
TC06001510.hg.1 1.2672720 6.026106 9.546954 0.0000056 0.0041758 4.4915665 IER3 immediate early response 3
TC01003017.hg.1 1.3824824 5.519782 9.516520 0.0000058 0.0041842 4.4683788 TSPAN2 tetraspanin 2
TC0X000544.hg.1 1.2795482 3.584735 9.514040 0.0000058 0.0041842 4.4664850 — —
TC17002655.hg.1 -1.2837079 7.561171 -9.508435 0.0000058 0.0041842 4.4622041 UBTF upstream binding transcription factor, RNA polymerase I
TC10002572.hg.1 1.2044414 7.506922 9.493891 0.0000059 0.0041942 4.4510806 — —
TC04001347.hg.1 1.2519575 4.942725 9.481393 0.0000060 0.0041972 4.4415061 HPSE heparanase
PSR05023580.hg.1 -1.1863848 2.761535 -9.460161 0.0000061 0.0042326 4.4252068 — —
TC07002670.hg.1 -1.2356097 5.353293 -9.444517 0.0000061 0.0042482 4.4131695 — —
TC01002654.hg.1 1.2058406 5.310344 9.256360 0.0000072 0.0049582 4.2665509 RAB3B RAB3B, member RAS oncogene family
TC03000892.hg.1 1.3343086 5.629290 9.172838 0.0000078 0.0052817 4.2003608 SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
TC13001686.hg.1 1.2066875 3.720103 9.163139 0.0000079 0.0052817 4.1926301 — —
TC0X002342.hg.1 1.2206151 3.568012 9.125141 0.0000081 0.0053808 4.1622515 SPANXC SPANX family, member C
TC03000026.hg.1 1.1957377 5.686441 9.114198 0.0000082 0.0053808 4.1534760 LMCD1 LIM and cysteine-rich domains 1
TC05001205.hg.1 -1.1271463 7.195126 -9.110599 0.0000082 0.0053808 4.1505877 CDH10 cadherin 10, type 2 (T2-cadherin)
TC10002092.hg.1 1.1302841 7.177654 9.087608 0.0000084 0.0054013 4.1321040 ARID5B AT rich interactive domain 5B (MRF1-like)
TC01002205.hg.1 0.9580574 10.582865 9.084390 0.0000084 0.0054013 4.1295120 NPPB natriuretic peptide B
TC12001755.hg.1 1.1385946 6.451162 9.060016 0.0000086 0.0054013 4.1098503 CSRP2 cysteine and glycine-rich protein 2
TC10000483.hg.1 -1.2079016 4.790106 -9.051553 0.0000087 0.0054013 4.1030095 KAT6B K(lysine) acetyltransferase 6B
TC07000718.hg.1 1.4648923 6.708815 9.505403 0.0000088 0.0054013 4.1008111 TES testis derived transcript (3 LIM domains)
TC10002843.hg.1 -1.5773409 8.000380 -9.865433 0.0000089 0.0054013 4.0917032 GFRA1 GDNF family receptor alpha 1
TC02004734.hg.1 -1.2031899 3.605814 -9.028645 0.0000089 0.0054013 4.0844557 PDE1A phosphodiesterase 1A, calmodulin-dependent
TC03000865.hg.1 1.2039883 7.877590 8.982978 0.0000092 0.0055696 4.0473099 MLF1 myeloid leukemia factor 1
47419903_st 1.1155079 2.784691 8.966052 0.0000094 0.0056075 4.0334885 — —
TC03000565.hg.1 2.4191435 5.798915 11.881649 0.0000089 0.0054013 4.0291543 — —
TC01005541.hg.1 1.2234518 2.593993 8.898147 0.0000100 0.0058844 3.9777429 — —
TC14001710.hg.1 1.2299094 5.893012 8.894376 0.0000100 0.0058844 3.9746332 ARID4A AT rich interactive domain 4A (RBP1-like)
TC16000266.hg.1 1.1842423 5.228008 8.862291 0.0000103 0.0060089 3.9481150 LOC554206 leucine carboxyl methyltransferase 1 pseudogene
3671544_st -1.1250916 5.849342 -8.836526 0.0000106 0.0061017 3.9267439 — —
3662452_st -1.1150538 6.560390 -8.796630 0.0000109 0.0062190 3.8935133 — —
TC08001816.hg.1 1.2229273 5.104902 8.786375 0.0000111 0.0062190 3.8849453 SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
TC12001276.hg.1 1.1721905 3.591874 8.781293 0.0000111 0.0062190 3.8806949 MGP matrix Gla protein
TC05002066.hg.1 1.1954451 7.058286 8.780587 0.0000111 0.0062190 3.8801041 DUSP1 dual specificity phosphatase 1
TC17000551.hg.1 1.1457813 6.784635 8.770594 0.0000112 0.0062221 3.8717377 ARL4D ADP-ribosylation factor-like 4D
PSR17013958.hg.1 -1.0630981 8.102072 -8.762936 0.0000113 0.0062221 3.8653196 — —
TC14001140.hg.1 1.2230304 5.363965 8.737333 0.0000116 0.0062836 3.8438152 TXNDC16 thioredoxin domain containing 16
TC06000010.hg.1 -1.1098311 6.037272 -8.735456 0.0000116 0.0062836 3.8422362 FOXF2 forkhead box F2
TC15000270.hg.1 1.9916363 6.083402 10.586908 0.0000121 0.0064493 3.8126938 THBS1 thrombospondin 1
TC06002112.hg.1 1.0868575 7.182241 8.694021 0.0000120 0.0064493 3.8072794 CTGF connective tissue growth factor
TC07001206.hg.1 1.4237986 4.601046 8.918107 0.0000125 0.0064550 3.7831530 OSBPL3 oxysterol binding protein-like 3
47423115_st 0.9683046 2.046834 8.660095 0.0000124 0.0064550 3.7785218 — —
TC12002937.hg.1 -1.4557260 5.545274 -9.085987 0.0000127 0.0064550 3.7760615 GRIP1 glutamate receptor interacting protein 1
TC05000697.hg.1 -1.1662051 7.681611 -8.632035 0.0000127 0.0064550 3.7546431 KIF20A kinesin family member 20A
TC21000025.hg.1 1.2420732 4.315076 8.630494 0.0000128 0.0064550 3.7533297 RBM11 RNA binding motif protein 11
47422029_st 1.1504357 3.962426 8.628083 0.0000128 0.0064550 3.7512736 — —
TC01001372.hg.1 1.1373164 5.294449 8.627387 0.0000128 0.0064550 3.7506797 SLAMF7 SLAM family member 7
TC04002625.hg.1 1.1884944 6.405247 8.625870 0.0000128 0.0064550 3.7493857 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2
TC08002539.hg.1 1.1500787 6.741129 8.618981 0.0000129 0.0064550 3.7435057 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
TC19000686.hg.1 1.0675069 7.336557 8.593549 0.0000132 0.0065179 3.7217547 SNAR-A12 small ILF3/NF90-associated RNA A12
TC19000693.hg.1 1.0675069 7.336557 8.593549 0.0000132 0.0065179 3.7217547 SNAR-A12 small ILF3/NF90-associated RNA A12
TC06000135.hg.1 1.1007752 5.574145 8.550119 0.0000138 0.0066972 3.6844489 SOX4 SRY (sex determining region Y)-box 4
TC19001740.hg.1 1.1615658 6.756644 8.542470 0.0000139 0.0066972 3.6778573 SNAR-B2 small ILF3/NF90-associated RNA B2
TC19001741.hg.1 1.1615658 6.756644 8.542470 0.0000139 0.0066972 3.6778573 SNAR-B2 small ILF3/NF90-associated RNA B2
TC09001842.hg.1 1.1379284 4.364611 8.532833 0.0000140 0.0067123 3.6695442 — —
TC07000998.hg.1 -1.0441037 7.846193 -8.518843 0.0000142 0.0067553 3.6574571 LRRC61 leucine rich repeat containing 61
TC08001440.hg.1 1.1521365 4.565680 8.503394 0.0000144 0.0067829 3.6440845 TP53INP1 tumor protein p53 inducible nuclear protein 1
TC01005049.hg.1 -1.1154840 6.706177 -8.500294 0.0000144 0.0067829 3.6413973 BROX BRO1 domain and CAAX motif containing
TC03002108.hg.1 1.4302520 7.940357 9.105083 0.0000150 0.0069536 3.6297439 CLDN1 claudin 1
TC12001689.hg.1 -1.2214820 5.395768 -8.461535 0.0000150 0.0069536 3.6077201 GRIP1 glutamate receptor interacting protein 1
TC12000189.hg.1 1.5101630 5.757045 9.099817 0.0000154 0.0070398 3.6075972 EMP1 epithelial membrane protein 1
47424278_st 0.8530666 1.128356 8.452727 0.0000151 0.0069560 3.6000431 — —
TC16001464.hg.1 1.1498940 5.213752 8.369010 0.0000163 0.0074359 3.5266534 LOC554206 leucine carboxyl methyltransferase 1 pseudogene
TC06000758.hg.1 1.0891894 5.188803 8.324113 0.0000171 0.0076945 3.4869727 SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
TC05002418.hg.1 -0.9497168 9.311286 -8.319938 0.0000171 0.0076945 3.4832708 CCNB1 cyclin B1
TC15002198.hg.1 1.3614852 2.547238 8.807987 0.0000178 0.0078123 3.4701497 TMOD2 tropomodulin 2 (neuronal)
TC19000694.hg.1 1.0517188 6.783431 8.303742 0.0000174 0.0077198 3.4688935 SNAR-C3 small ILF3/NF90-associated RNA C3
TC20000481.hg.1 -1.0595905 6.635584 -8.303353 0.0000174 0.0077198 3.4685482 CDH4 cadherin 4, type 1, R-cadherin (retinal)
TC07003174.hg.1 1.2089421 4.644248 8.293719 0.0000176 0.0077430 3.4599811 MKLN1-AS MKLN1 antisense RNA
TC01002772.hg.1 1.1989654 8.302093 8.456684 0.0000179 0.0078123 3.4504647 RP11-180O5.2 putative novel transcript
47419722_st 1.0337032 1.350257 8.440332 0.0000183 0.0079037 3.4320204 — —
TC05003094.hg.1 -1.2267202 6.666424 -8.399346 0.0000184 0.0079037 3.4268526 — —
TC13001320.hg.1 1.0280194 2.774623 8.227517 0.0000187 0.0079598 3.4008295 GAS6-AS2 GAS6 antisense RNA 2 (head to head)
TC08002303.hg.1 1.0235748 2.496484 8.227012 0.0000187 0.0079598 3.4003761 SFRP1 secreted frizzled-related protein 1
TC07000112.hg.1 1.3143762 7.871421 8.610696 0.0000192 0.0080808 3.3976306 AHR aryl hydrocarbon receptor
TC05001854.hg.1 1.1226400 5.240789 8.199108 0.0000193 0.0080808 3.3752932 HBEGF heparin-binding EGF-like growth factor
TC01000863.hg.1 1.2583620 7.310026 8.436836 0.0000198 0.0081938 3.3664048 FNBP1L formin binding protein 1-like
TC0Y000117.hg.1 1.1371523 6.838315 8.177732 0.0000197 0.0081938 3.3560175 ASMTL acetylserotonin O-methyltransferase-like
TC05002611.hg.1 1.0126672 6.937758 8.163718 0.0000199 0.0081938 3.3433521 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TC10001193.hg.1 1.0874792 6.595662 8.160670 0.0000200 0.0081938 3.3405945 CCNYL2 cyclin Y-like 2
TC16000823.hg.1 -1.0031590 7.771926 -8.148017 0.0000202 0.0082476 3.3291347 CREBBP CREB binding protein
TC16000455.hg.1 1.0225720 6.671837 8.136308 0.0000205 0.0082945 3.3185142 LPCAT2 lysophosphatidylcholine acyltransferase 2
TC16000479.hg.1 -1.1463304 9.016500 -8.305463 0.0000211 0.0084116 3.3021758 SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
TC03001812.hg.1 -1.1337075 5.979577 -8.111939 0.0000210 0.0084116 3.2963590 STAG1 stromal antigen 1
TC12003271.hg.1 1.0989414 4.584809 8.105338 0.0000211 0.0084116 3.2903464 KLRC3 killer cell lectin-like receptor subfamily C, member 3
TC05001610.hg.1 1.1115027 7.053117 8.085889 0.0000215 0.0085187 3.2725999 ELL2 elongation factor, RNA polymerase II, 2
TC22000350.hg.1 1.0641857 5.343226 8.042545 0.0000224 0.0088111 3.2328916 SEPT3 septin 3
TC05001268.hg.1 1.0806848 7.033865 8.037489 0.0000226 0.0088111 3.2282458 LMBRD2 LMBR1 domain containing 2
3015381_st -1.0369975 6.205012 -8.034646 0.0000226 0.0088111 3.2256320 — —
TC03000465.hg.1 1.1178342 6.634103 7.994396 0.0000235 0.0090002 3.1885240 ZNF654 zinc finger protein 654
TC03003361.hg.1 1.1756243 4.353448 7.991797 0.0000236 0.0090002 3.1861216 PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2
TC02001974.hg.1 1.0486129 5.619701 7.986306 0.0000237 0.0090002 3.1810430 PAIP2B poly(A) binding protein interacting protein 2B
TC20001661.hg.1 -0.9803798 8.623732 -7.984380 0.0000238 0.0090002 3.1792602 AURKA aurora kinase A
TC12000495.hg.1 1.0469627 5.528818 7.980286 0.0000239 0.0090002 3.1754702 DGKA diacylglycerol kinase, alpha 80kDa
TC01005517.hg.1 -1.0781741 4.239178 -7.980231 0.0000239 0.0090002 3.1754193 DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
TC03000534.hg.1 1.0702596 6.733300 7.969198 0.0000241 0.0090510 3.1651964 ALCAM activated leukocyte cell adhesion molecule
47421529_st -1.1574379 2.349595 -8.179516 0.0000251 0.0092667 3.1464114 — —
TC05002634.hg.1 -0.9942890 6.572281 -7.938839 0.0000249 0.0092667 3.1369900 JADE2 jade family PHD finger 2
TC19001563.hg.1 1.0134289 6.076180 7.929619 0.0000251 0.0092667 3.1284023 ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
TC05000604.hg.1 -0.9797874 7.339381 -7.919703 0.0000253 0.0092893 3.1191556 LMNB1 lamin B1
TC08000505.hg.1 1.0779127 4.985943 7.916744 0.0000254 0.0092893 3.1163932 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
TC19000692.hg.1 0.9853916 6.793011 7.909261 0.0000256 0.0093107 3.1094050 SNAR-C4 small ILF3/NF90-associated RNA C4
TC13000748.hg.1 -0.9290589 9.014346 -7.886339 0.0000262 0.0094778 3.0879550 EDNRB endothelin receptor type B
TC0X000800.hg.1 1.1334166 6.607121 7.896517 0.0000267 0.0096093 3.0725689 ASMTL acetylserotonin O-methyltransferase-like
TC11002162.hg.1 1.1081564 4.134794 7.856382 0.0000270 0.0096257 3.0598278 SYTL2 synaptotagmin-like 2
TC18000208.hg.1 -0.9874586 6.267054 -7.855678 0.0000270 0.0096257 3.0591656 ZNF532 zinc finger protein 532
TC17001711.hg.1 0.9954665 6.023914 7.847203 0.0000273 0.0096593 3.0511875 MMD monocyte to macrophage differentiation-associated
TC06002124.hg.1 1.0454856 3.184260 7.840860 0.0000274 0.0096725 3.0452108 SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12
PSR17016921.hg.1 -0.9418244 8.321454 -7.833332 0.0000276 0.0096976 3.0381112 — —
TC0X000829.hg.1 0.9842545 6.453555 7.814727 0.0000282 0.0097920 3.0205367 KAL1 Kallmann syndrome 1 sequence
TC02002425.hg.1 -1.0811355 5.836464 -7.813890 0.0000282 0.0097920 3.0197447 NMI N-myc (and STAT) interactor
TC05000298.hg.1 -0.9441888 8.271861 -7.788242 0.0000289 0.0099739 2.9954460 CCNB1 cyclin B1
TC11001642.hg.1 -1.0797303 2.840642 -7.782644 0.0000291 0.0099739 2.9901311 — —
TC02003749.hg.1 1.0246639 3.776096 7.780580 0.0000292 0.0099739 2.9881709 — —
TC03002690.hg.1 0.9909101 3.007660 7.775828 0.0000293 0.0099739 2.9836560 — —
TC02002574.hg.1 1.0274322 5.296881 7.771605 0.0000294 0.0099739 2.9796405 FKBP7 FK506 binding protein 7
TC08002129.hg.1 -0.9816444 6.799001 -7.755403 0.0000299 0.0100393 2.9642171 CHRAC1 chromatin accessibility complex 1
TC05002954.hg.1 1.0524280 7.160288 7.753151 0.0000300 0.0100393 2.9620706 — —
47419787_st 0.8259243 1.300042 7.746511 0.0000302 0.0100393 2.9557385 — —
TC01004733.hg.1 -1.0373226 4.262875 -7.746375 0.0000302 0.0100393 2.9556087 RP11-107M16.2 novel transcript
TC01001777.hg.1 1.4550516 5.554707 8.442625 0.0000320 0.0102449 2.9518731 ATF3 activating transcription factor 3
TC0X001522.hg.1 -1.1429648 7.321343 -7.873508 0.0000310 0.0101575 2.9440696 HCFC1 host cell factor C1
TC12002835.hg.1 1.0248755 3.872234 7.728996 0.0000307 0.0101575 2.9390093 — —
TC12001168.hg.1 0.9743631 6.168199 7.724116 0.0000309 0.0101575 2.9343413 SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14
TC04000469.hg.1 1.1798226 5.429519 7.806890 0.0000317 0.0102449 2.9174648 PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
TC11000808.hg.1 0.9059914 9.336893 7.705720 0.0000315 0.0102449 2.9167197 SNORD15B small nucleolar RNA, C/D box 15B
TC08002364.hg.1 0.9397643 8.221075 7.699164 0.0000317 0.0102449 2.9104290 MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
TC13001585.hg.1 -0.9249354 8.803455 -7.690744 0.0000319 0.0102449 2.9023432 EDNRB endothelin receptor type B
TC07000688.hg.1 1.0178187 6.180303 7.680437 0.0000323 0.0102449 2.8924329 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
TC10002196.hg.1 1.0400069 4.469154 7.678721 0.0000323 0.0102449 2.8907810 FAS Fas cell surface death receptor
47422171_st -1.0209658 2.359884 -7.676829 0.0000324 0.0102449 2.8889605 — —
TC22000551.hg.1 1.2549308 3.072774 7.951240 0.0000344 0.0107040 2.8602079 ZNF280A zinc finger protein 280A
TC02000270.hg.1 1.0574654 3.356992 7.635444 0.0000338 0.0106349 2.8490171 PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
TC08000146.hg.1 -0.9585274 7.129051 -7.631655 0.0000339 0.0106349 2.8453494 SH2D4A SH2 domain containing 4A
TC04002094.hg.1 1.1776946 5.662757 7.774321 0.0000346 0.0107040 2.8410928 PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
TC04002014.hg.1 -0.9990497 5.685802 -7.616018 0.0000345 0.0107040 2.8301943 DANCR differentiation antagonizing non-protein coding RNA
TC02000281.hg.1 0.9651030 6.739660 7.573378 0.0000360 0.0110861 2.7887149 EPAS1 endothelial PAS domain protein 1
TC0X001186.hg.1 1.0070607 3.685201 7.569989 0.0000362 0.0110861 2.7854073 RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
TC04001402.hg.1 1.0220474 4.475462 7.561248 0.0000365 0.0111383 2.7768730 TSPAN5 tetraspanin 5
TC13000445.hg.1 -1.4195052 1.977393 -8.724166 0.0000404 0.0117240 2.7637902 — —
3670236_st -0.9480204 9.302448 -7.546933 0.0000370 0.0112559 2.7628742 — —
TC12001197.hg.1 0.9153539 2.041815 7.542027 0.0000372 0.0112647 2.7580713 — —
TC09002903.hg.1 0.9520645 6.084231 7.535865 0.0000375 0.0112884 2.7520335 TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TC06002863.hg.1 1.0017331 3.583564 7.529178 0.0000377 0.0113186 2.7454760 OGFRL1 opioid growth factor receptor-like 1
TC10001678.hg.1 -1.0063516 8.271878 -7.502172 0.0000388 0.0115499 2.7189377 GFRA1 GDNF family receptor alpha 1
TC13000749.hg.1 -0.9589048 9.583745 -7.508926 0.0000390 0.0115499 2.7143122 RP11-318G21.4 putative novel transcript
TC13000234.hg.1 1.0425796 4.144968 7.493457 0.0000391 0.0115499 2.7103531 PCDH17 protocadherin 17
PSR17016934.hg.1 -0.9638365 9.087834 -7.492271 0.0000392 0.0115499 2.7091848 — —
TC22000575.hg.1 -0.9666629 3.247220 -7.489469 0.0000393 0.0115499 2.7064225 — —
TC17001742.hg.1 0.9961865 4.540229 7.477114 0.0000398 0.0116075 2.6942301 RNU1-85P RNA, U1 small nuclear 85, pseudogene
47420069_st -1.0013373 4.892952 -7.476739 0.0000398 0.0116075 2.6938594 — —
TC20001236.hg.1 1.0073467 6.181838 7.443449 0.0000412 0.0119198 2.6609104 SEMG1 semenogelin I
TC12001226.hg.1 1.0553201 4.137911 7.426166 0.0000420 0.0120880 2.6437495 STYK1 serine/threonine/tyrosine kinase 1
TC15001420.hg.1 -0.9883288 1.459456 -7.696024 0.0000435 0.0122211 2.6394796 — —
TC03000482.hg.1 0.9778338 3.255679 7.419885 0.0000423 0.0121065 2.6375031 OR5AC2 olfactory receptor, family 5, subfamily AC, member 2
3662477_st -0.9371198 6.498695 -7.416956 0.0000424 0.0121065 2.6345884 — —
47419841_st 0.8470807 2.162300 7.410305 0.0000427 0.0121422 2.6279659 — —
TC07000306.hg.1 1.0166667 4.922665 7.403256 0.0000430 0.0121833 2.6209412 C7orf57 chromosome 7 open reading frame 57
TC05001289.hg.1 1.0366513 4.910985 7.397599 0.0000433 0.0122070 2.6152993 LIFR leukemia inhibitory factor receptor alpha
3671554_st -0.9245574 8.044584 -7.388924 0.0000437 0.0122211 2.6066391 — —
TC11002293.hg.1 1.0104722 6.911212 7.374259 0.0000443 0.0123622 2.5919768 IL18 interleukin 18
TC06000110.hg.1 0.9632652 6.390734 7.361849 0.0000449 0.0124758 2.5795481 GMPR guanosine monophosphate reductase
TC08001156.hg.1 0.9612525 7.714370 7.354160 0.0000453 0.0125281 2.5718372 TM2D2 TM2 domain containing 2
TC05001011.hg.1 -0.9224573 6.267106 -7.326241 0.0000467 0.0127923 2.5437753 NSD1 nuclear receptor binding SET domain protein 1
TC15000769.hg.1 0.9802423 5.556451 7.316092 0.0000472 0.0127923 2.5335494 — —
TC15000782.hg.1 0.9802423 5.556451 7.316092 0.0000472 0.0127923 2.5335494 — —
TC15000804.hg.1 0.9802423 5.556451 7.316092 0.0000472 0.0127923 2.5335494 — —
TC15001780.hg.1 0.9802423 5.556451 7.316092 0.0000472 0.0127923 2.5335494 — —
TC06001770.hg.1 1.1430903 5.319004 7.433773 0.0000487 0.0131122 2.5186755 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
47424705_st -0.8923420 1.918045 -7.297895 0.0000481 0.0129917 2.5151813 — —
TC04000297.hg.1 -1.0249016 5.657033 -7.272759 0.0000494 0.0132422 2.4897376 DANCR differentiation antagonizing non-protein coding RNA
TC05000736.hg.1 0.9610288 4.848933 7.259757 0.0000501 0.0133761 2.4765442 VTRNA1-3 vault RNA 1-3
TC03001175.hg.1 0.9193101 6.007341 7.246574 0.0000508 0.0134844 2.4631444 TMEM40 transmembrane protein 40
TC07000329.hg.1 -0.9206718 6.489265 -7.245126 0.0000509 0.0134844 2.4616714 LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
TC15001883.hg.1 0.7890630 1.849292 7.241084 0.0000511 0.0134920 2.4575575 — —
TC15000449.hg.1 -0.8960890 7.205334 -7.228345 0.0000518 0.0135554 2.4445776 CCNB2 cyclin B2
TC08000459.hg.1 0.9552926 3.825022 7.227302 0.0000518 0.0135554 2.4435139 LOC101929759 uncharacterized LOC101929759
TC13000741.hg.1 0.9545038 4.931910 7.225452 0.0000519 0.0135554 2.4416278 KCTD12 potassium channel tetramerization domain containing 12
TC06000628.hg.1 0.9703747 4.935704 7.222797 0.0000521 0.0135554 2.4389190 SLC25A27 solute carrier family 25, member 27
TC08000531.hg.1 0.9609660 4.847929 7.213298 0.0000526 0.0136325 2.4292201 CA2 carbonic anhydrase II
TC08001683.hg.1 -0.8972434 6.754549 -7.208757 0.0000529 0.0136325 2.4245787 CASC7 cancer susceptibility candidate 7 (non-protein coding)
3671550_st -0.9488700 7.107070 -7.204735 0.0000531 0.0136325 2.4204666 — —
TC01004481.hg.1 -0.9071079 7.416082 -7.203515 0.0000532 0.0136325 2.4192182 TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
TC16000274.hg.1 1.1619052 4.304336 7.328939 0.0000542 0.0136325 2.4165120 — —
TC09002901.hg.1 0.9776100 6.158525 7.197027 0.0000535 0.0136325 2.4125792 S1PR3 sphingosine-1-phosphate receptor 3
TC10002135.hg.1 -1.0345410 4.355830 -7.186769 0.0000541 0.0136325 2.4020693 ZNF503-AS1 novel transcript (LOC253264)
TC15001476.hg.1 0.8790749 7.830915 7.183820 0.0000543 0.0136325 2.3990459 MNS1 meiosis-specific nuclear structural 1
TC10000639.hg.1 1.1001553 3.585678 7.235101 0.0000548 0.0136325 2.3982375 IFIT1 interferon-induced protein with tetratricopeptide repeats 1
47424420_st -0.9158648 1.843772 -7.238886 0.0000549 0.0136325 2.3964144 — —
TC12002388.hg.1 1.0035416 4.027157 7.177689 0.0000547 0.0136325 2.3927559 ERBB3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
TC16001862.hg.1 -0.9437881 6.291493 -7.177099 0.0000547 0.0136325 2.3921502 — —
TC07000562.hg.1 0.8956719 6.777595 7.175060 0.0000548 0.0136325 2.3900572 PEG10 paternally expressed 10
TC18000213.hg.1 1.3314699 7.747921 7.888939 0.0000596 0.0141158 2.3877788 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
47419721_st 0.7356327 1.217580 7.163353 0.0000555 0.0136732 2.3780281 — —
TC12001807.hg.1 1.1038898 6.094805 7.305710 0.0000568 0.0137681 2.3758518 BTG1 B-cell translocation gene 1, anti-proliferative
3672407_st -0.9125639 7.805064 -7.158739 0.0000558 0.0136732 2.3732821 — —
TC08001286.hg.1 0.8943167 7.792909 7.157455 0.0000559 0.0136732 2.3719610 MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
TC19002244.hg.1 -0.8164257 9.594225 -7.156939 0.0000559 0.0136732 2.3714303 — —
3015385_st -0.9382686 6.024389 -7.154864 0.0000560 0.0136732 2.3692948 — —
TC02001350.hg.1 0.8772283 8.597799 7.139455 0.0000570 0.0137681 2.3534174 ACSL3 acyl-CoA synthetase long-chain family member 3
TC04000135.hg.1 -0.8863366 7.201327 -7.138877 0.0000570 0.0137681 2.3528212 LINC01085 long intergenic non-protein coding RNA 1085
TC08001112.hg.1 1.2268133 4.671153 7.400905 0.0000595 0.0141158 2.3464979 TEX15 testis expressed 15
TC06002708.hg.1 0.8754800 7.611197 7.115409 0.0000585 0.0140218 2.3285774 — —
TC0X000082.hg.1 1.0679060 4.581157 7.113525 0.0000586 0.0140218 2.3266279 REPS2 RALBP1 associated Eps domain containing 2
PSR17008059.hg.1 -0.9776022 6.624990 -7.112529 0.0000587 0.0140218 2.3255966 — —
TC01001505.hg.1 0.9568747 6.349016 7.097021 0.0000596 0.0141158 2.3095298 SUCO SUN domain containing ossification factor
TC01000814.hg.1 1.0014819 3.112301 7.085343 0.0000604 0.0142479 2.2974096 WDR63 WD repeat domain 63
TC13000161.hg.1 1.1077139 6.339688 7.270810 0.0000624 0.0144322 2.2917340 LACC1 laccase (multicopper oxidoreductase) domain containing 1
TC06002832.hg.1 1.0247620 5.318102 7.074312 0.0000611 0.0143183 2.2859440 LOC730101 uncharacterized LOC730101
TC19001657.hg.1 0.9075829 6.736186 7.073340 0.0000612 0.0143183 2.2849338 SNAR-E small ILF3/NF90-associated RNA E
TC01001212.hg.1 1.1879263 7.501996 7.469401 0.0000646 0.0147082 2.2840498 TUFT1 tuftelin 1
TC02004895.hg.1 -0.9533081 4.949992 -7.071620 0.0000613 0.0143183 2.2831439 — —
TC17000461.hg.1 -0.9157995 7.063747 -7.067740 0.0000616 0.0143313 2.2791057 ARHGAP23 Rho GTPase activating protein 23
PSR17014493.hg.1 -0.8591766 7.988025 -7.058533 0.0000622 0.0144280 2.2695153 — —
3671552_st -0.9613746 6.782430 -7.040003 0.0000635 0.0146260 2.2501804 — —
TC12001798.hg.1 1.3955832 7.512443 7.936107 0.0000704 0.0150499 2.2495829 ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
TC18000142.hg.1 0.8957767 6.206246 7.033376 0.0000639 0.0146614 2.2432536 MAPRE2 microtubule-associated protein, RP/EB family, member 2
TC08001864.hg.1 -0.8685652 7.376177 -7.031815 0.0000640 0.0146614 2.2416220 RBPMS RNA binding protein with multiple splicing
TC16000392.hg.1 -1.1898738 4.401374 -7.263551 0.0000668 0.0148233 2.2335939 — —
TC16001068.hg.1 -1.1898738 4.401374 -7.263551 0.0000668 0.0148233 2.2335939 — —
TC05001021.hg.1 1.1263875 4.053606 7.142527 0.0000659 0.0148233 2.2313628 RP11-1101H11.1 putative novel transcript
TC10000377.hg.1 0.9192229 5.907415 7.020267 0.0000648 0.0147082 2.2295352 ARID5B AT rich interactive domain 5B (MRF1-like)
TC12002059.hg.1 1.0121134 6.127728 7.025780 0.0000651 0.0147082 2.2273212 OASL 2-5-oligoadenylate synthetase-like
TC11002283.hg.1 -0.8350770 2.111434 -7.017172 0.0000651 0.0147082 2.2262930 — —
TC12000694.hg.1 0.9767741 8.878207 7.124147 0.0000664 0.0148233 2.2230513 TMTC3 transmembrane and tetratricopeptide repeat containing 3
TC08002532.hg.1 -0.9144186 6.525814 -7.001687 0.0000662 0.0148233 2.2100522 — —
PSR17013956.hg.1 -0.8799355 6.266341 -6.988556 0.0000671 0.0148233 2.1962543 — —
TC19000687.hg.1 0.8784562 6.708902 6.983995 0.0000675 0.0148233 2.1914562 SNAR-C2 small ILF3/NF90-associated RNA C2
TC19000690.hg.1 0.8784562 6.708902 6.983995 0.0000675 0.0148233 2.1914562 SNAR-C2 small ILF3/NF90-associated RNA C2
TC19000695.hg.1 0.8784562 6.708902 6.983995 0.0000675 0.0148233 2.1914562 SNAR-C2 small ILF3/NF90-associated RNA C2
TC06000684.hg.1 -0.9030224 8.393135 -6.980876 0.0000677 0.0148279 2.1881739 BAG2 BCL2-associated athanogene 2
47419687_st -0.8892489 1.429520 -7.127736 0.0000695 0.0149968 2.1842138 — —
TC04001919.hg.1 -0.9237542 7.339689 -6.966181 0.0000688 0.0149968 2.1726892 — —
TC06000658.hg.1 0.8568790 7.951566 6.959354 0.0000693 0.0149968 2.1654856 TMEM14A transmembrane protein 14A
TC05000232.hg.1 -0.8840520 7.203530 -6.957333 0.0000695 0.0149968 2.1633522 GPX8 glutathione peroxidase 8 (putative)
TC03002443.hg.1 -0.9262848 5.216925 -6.956707 0.0000695 0.0149968 2.1626906 — —
TC06000886.hg.1 -0.9329205 6.207015 -6.953025 0.0000698 0.0150091 2.1588017 GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa
3670189_st -0.7780999 9.548257 -6.947624 0.0000702 0.0150499 2.1530934 — —
TC12001296.hg.1 1.0272381 8.354567 7.108834 0.0000724 0.0152050 2.1477503 RECQL RecQ helicase-like
TC01000411.hg.1 0.8818057 6.025880 6.935538 0.0000712 0.0151112 2.1403061 TINAGL1 tubulointerstitial nephritis antigen-like 1
TC05000612.hg.1 0.8731229 6.735623 6.934394 0.0000713 0.0151112 2.1390948 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
PSR17014498.hg.1 -0.8645088 7.152412 -6.933137 0.0000714 0.0151112 2.1377633 — —
TC12003243.hg.1 0.9113116 5.018339 6.923215 0.0000721 0.0152050 2.1272471 ERBB3 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
PSR17014497.hg.1 -0.8874877 7.616414 -6.919397 0.0000724 0.0152050 2.1231975 — —
47419820_st -0.7143336 1.357886 -6.915387 0.0000728 0.0152272 2.1189409 — —
47424018_st 0.9011529 3.000567 6.895197 0.0000744 0.0155249 2.0974796 — —
TC05003439.hg.1 0.9428012 5.183238 6.873950 0.0000762 0.0158480 2.0748332 ITGA1 integrin, alpha 1
TC08001532.hg.1 0.9145945 4.438779 6.867621 0.0000767 0.0159127 2.0680759 KCNV1 potassium channel, subfamily V, member 1
47420566_st -0.8314094 1.671952 -6.863861 0.0000770 0.0159324 2.0640586 — —
3662462_st -1.0665811 7.579340 -7.076169 0.0000800 0.0164441 2.0604884 — —
TC22000758.hg.1 -0.9058083 3.703252 -6.847426 0.0000785 0.0161787 2.0464763 — —
PSR17008066.hg.1 -0.8243152 8.203475 -6.827068 0.0000803 0.0164535 2.0246447 — —
TC17002878.hg.1 1.1274281 5.919001 7.081171 0.0000836 0.0168967 2.0238444 ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
TC07000741.hg.1 0.9310357 4.491591 6.821727 0.0000807 0.0165039 2.0189079 FEZF1-AS1 FEZF1 antisense RNA 1
TC12002824.hg.1 1.0962804 6.112693 7.044320 0.0000837 0.0168967 2.0183666 AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae)
TC09000899.hg.1 0.8961552 5.317213 6.811625 0.0000817 0.0166428 2.0080458 GLDC glycine dehydrogenase (decarboxylating)
TC19000081.hg.1 0.9666685 4.969630 6.803207 0.0000824 0.0167516 1.9989847 CREB3L3 cAMP responsive element binding protein 3-like 3
TC0X002243.hg.1 -0.8196852 8.687916 -6.787802 0.0000839 0.0168967 1.9823757 RBMX RNA binding motif protein, X-linked
TC06001027.hg.1 1.4665315 7.784285 7.884469 0.0000966 0.0188644 1.9793697 TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TC17001341.hg.1 -1.1417293 4.585554 -6.997567 0.0000877 0.0175113 1.9739109 EVI2B ecotropic viral integration site 2B
TC06000985.hg.1 1.1615806 5.667111 7.085081 0.0000894 0.0178036 1.9685874 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
TC07003166.hg.1 0.9319279 7.429226 6.773513 0.0000852 0.0171204 1.9669404 — —
TC04001698.hg.1 0.9141764 4.627617 6.768338 0.0000857 0.0171711 1.9613439 NPY1R neuropeptide Y receptor Y1
TC19002497.hg.1 1.5928633 5.614173 7.953693 0.0001020 0.0193808 1.9383793 — —
TC05002612.hg.1 0.9580927 5.428937 6.728371 0.0000896 0.0178084 1.9179915 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
TC07001189.hg.1 0.8665499 3.027404 6.719105 0.0000906 0.0179448 1.9079086 LOC541472 uncharacterized LOC541472
TC06000779.hg.1 0.8834436 5.424527 6.715756 0.0000909 0.0179622 1.9042619 NT5E 5-nucleotidase, ecto (CD73)
TC02002445.hg.1 0.8978188 4.926196 6.710124 0.0000915 0.0180263 1.8981247 NR4A2 nuclear receptor subfamily 4, group A, member 2
TC08002291.hg.1 1.2098479 6.899834 7.222079 0.0000996 0.0190813 1.8939896 RAB11FIP1 RAB11 family interacting protein 1 (class I)
TC06000185.hg.1 0.8654129 6.293170 6.697434 0.0000928 0.0182355 1.8842801 BTN2A2 butyrophilin, subfamily 2, member A2
47424374_st -1.0921439 2.515149 -7.040069 0.0000984 0.0190536 1.8823379 — —
TC19000906.hg.1 -0.7515474 9.493367 -6.688995 0.0000937 0.0183592 1.8750615 U2AF2 U2 small nuclear RNA auxiliary factor 2
2985876_st -2.0820121 5.566762 -9.016372 0.0001172 0.0207755 1.8652090 — —
TC17000871.hg.1 0.8001822 8.750838 6.659979 0.0000969 0.0188679 1.8432868 RNU6-24P RNA, U6 small nuclear 24, pseudogene
3670232_st -0.7921697 8.805243 -6.653687 0.0000975 0.0189508 1.8363814 — —
TC07001192.hg.1 1.2119981 7.544207 7.209717 0.0001066 0.0196716 1.8359004 FAM126A family with sequence similarity 126, member A
TC08001199.hg.1 0.9014046 5.782640 6.641996 0.0000988 0.0190536 1.8235348 SNAI2 snail family zinc finger 2
TC02002419.hg.1 1.0698978 7.406608 6.883676 0.0001033 0.0194999 1.8214640 RND3 Rho family GTPase 3
3662464_st -0.8638584 5.763020 -6.639988 0.0000991 0.0190536 1.8213265 — —
TC01002911.hg.1 0.8460958 6.554818 6.639277 0.0000992 0.0190536 1.8205449 FRRS1 ferric-chelate reductase 1
TC0X001832.hg.1 0.9449658 3.138005 6.633170 0.0000998 0.0190825 1.8138240 — —
TC02003747.hg.1 1.1553796 9.183296 7.260832 0.0001110 0.0200124 1.8076489 — —
47424053_st -1.0295694 1.540964 -7.173883 0.0001099 0.0199690 1.8063210 — —
TC16001513.hg.1 -0.8856068 7.192833 -6.624933 0.0001008 0.0192101 1.8047515 — —
47419608_st 0.9797622 2.217515 6.839764 0.0001058 0.0196180 1.7957701 — —
TC0X002051.hg.1 0.9542663 5.229751 6.609842 0.0001025 0.0194383 1.7881038 — —
TC20000896.hg.1 -0.8426933 6.315232 -6.602372 0.0001034 0.0194999 1.7798510 NCOA5 nuclear receptor coactivator 5
TC02001071.hg.1 1.0034627 6.251417 6.701530 0.0001059 0.0196180 1.7749824 OSBPL6 oxysterol binding protein-like 6
TC08002373.hg.1 -1.3421655 4.519787 -7.234521 0.0001159 0.0206492 1.7680234 — —
TC17001576.hg.1 -0.9041881 7.437390 -6.591268 0.0001047 0.0196180 1.7675696 UBTF upstream binding transcription factor, RNA polymerase I
47424532_st 0.7803095 1.978689 6.588907 0.0001050 0.0196180 1.7649563 — —
47424027_st -0.6915098 1.510418 -6.586759 0.0001053 0.0196180 1.7625774 — —
PSR17008062.hg.1 -0.8002833 8.171306 -6.583973 0.0001056 0.0196180 1.7594913 — —
TC18001000.hg.1 0.8674608 6.415416 6.580861 0.0001060 0.0196180 1.7560436 HMSD histocompatibility (minor) serpin domain containing
TC10000967.hg.1 0.8214665 7.202761 6.569707 0.0001073 0.0197663 1.7436720 IDI1 isopentenyl-diphosphate delta isomerase 1
TC06000759.hg.1 0.8741224 4.348033 6.563436 0.0001081 0.0198403 1.7367094 RNY4 RNA, Ro-associated Y4
PSR17013142.hg.1 -0.7326914 9.954654 -6.561901 0.0001083 0.0198403 1.7350039 — —
TC08002410.hg.1 0.7907970 2.078596 6.556950 0.0001089 0.0199016 1.7295018 — —
TC19001622.hg.1 1.0601662 6.233834 6.773487 0.0001135 0.0203206 1.7279751 — —
TC01005585.hg.1 0.8431780 5.637881 6.554057 0.0001093 0.0199161 1.7262843 — —
TC06001952.hg.1 0.8330956 2.962426 6.542438 0.0001108 0.0200124 1.7133532 EPHA7 EPH receptor A7
TC01003745.hg.1 0.8954550 7.042844 6.541373 0.0001109 0.0200124 1.7121666 NUAK2 NUAK family, SNF1-like kinase, 2
TC03003059.hg.1 0.8315871 7.430483 6.529469 0.0001124 0.0202254 1.6988962 — —
TC12003080.hg.1 1.2828220 3.821430 7.087438 0.0001238 0.0212994 1.6969280 GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
TC0Y000020.hg.1 0.9475214 3.970771 6.525941 0.0001129 0.0202560 1.6949593 AC010084.1 putative novel transcript
TC08002551.hg.1 -0.8077840 7.093055 -6.510186 0.0001149 0.0205224 1.6773558 — —
3676056_st -0.8270841 9.807115 -6.514038 0.0001172 0.0207755 1.6615803 — —
TC02002539.hg.1 0.8615119 4.848260 6.488512 0.0001179 0.0208312 1.6530808 GPR155 G protein-coupled receptor 155
TC08000324.hg.1 0.9508553 6.168502 6.520954 0.0001187 0.0208760 1.6525006 AP3M2 adaptor-related protein complex 3, mu 2 subunit
TC03000149.hg.1 0.9784041 4.198463 6.484171 0.0001185 0.0208760 1.6482104 TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TC07002488.hg.1 1.1344643 6.867308 6.879893 0.0001293 0.0217627 1.6345556 — —
TC10001674.hg.1 0.8411927 5.993151 6.471591 0.0001202 0.0210636 1.6340821 CCDC186 coiled-coil domain containing 186
3662440_st -0.8587825 8.662251 -6.468972 0.0001206 0.0210636 1.6311379 — —
TC01003796.hg.1 1.0224497 6.992302 6.668204 0.0001257 0.0214077 1.6282686 SLC30A1 solute carrier family 30 (zinc transporter), member 1
PSR17013131.hg.1 -0.7510879 8.943174 -6.466310 0.0001209 0.0210636 1.6281452 — —
TC06002168.hg.1 0.8046484 7.767712 6.466017 0.0001210 0.0210636 1.6278149 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
47419191_st -0.7000773 1.799735 -6.462436 0.0001215 0.0210990 1.6237869 — —
TC19000306.hg.1 -0.8274637 5.699970 -6.457192 0.0001222 0.0211755 1.6178835 — —
TC12000822.hg.1 0.8970200 4.091275 6.448282 0.0001235 0.0212994 1.6078444 TCP11L2 t-complex 11, testis-specific-like 2
TC07003105.hg.1 0.8284063 2.375067 6.445828 0.0001238 0.0212994 1.6050771 CCDC71L coiled-coil domain containing 71-like
TC14000211.hg.1 -0.8517639 5.083474 -6.438590 0.0001249 0.0213906 1.5969107 NPAS3 neuronal PAS domain protein 3
TC05001316.hg.1 0.7184963 9.771434 6.435903 0.0001253 0.0213906 1.5938779 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
TC06000117.hg.1 0.8193236 7.245536 6.435872 0.0001253 0.0213906 1.5938425 KDM1B lysine (K)-specific demethylase 1B
TC02002218.hg.1 2.5965332 4.875176 9.816667 0.0001649 0.0232694 1.5817642 IL1A interleukin 1, alpha
TC12000263.hg.1 0.9274135 6.863213 6.455780 0.0001279 0.0216836 1.5799898 STK38L serine/threonine kinase 38 like
TC03001077.hg.1 0.8911266 5.568738 6.421784 0.0001273 0.0216390 1.5779203 FAM43A family with sequence similarity 43, member A
PSR17013959.hg.1 -0.9718719 4.608242 -6.412651 0.0001291 0.0217627 1.5652215 — —
TC02004510.hg.1 0.8230102 5.662208 6.409380 0.0001292 0.0217627 1.5638779 — —
TC12000656.hg.1 -0.8771442 5.077381 -6.402157 0.0001303 0.0218758 1.5556905 NAV3 neuron navigator 3
TC21000594.hg.1 0.9974558 2.228124 6.709166 0.0001387 0.0224780 1.5529229 — —
TC03001663.hg.1 -0.8123661 6.042540 -6.398552 0.0001308 0.0218792 1.5516012 KIAA2018 KIAA2018
TC04000868.hg.1 1.2963363 5.207165 7.044969 0.0001466 0.0225897 1.5512052 WDR17 WD repeat domain 17
TC03001169.hg.1 0.8426862 4.988377 6.396987 0.0001311 0.0218792 1.5498258 TIMP4 TIMP metallopeptidase inhibitor 4
TC03000584.hg.1 0.8392701 3.645752 6.394590 0.0001314 0.0218792 1.5471057 GRAMD1C GRAM domain containing 1C
TC04000816.hg.1 0.8561575 3.546801 6.393897 0.0001315 0.0218792 1.5463190 AC005150.1 novel transcript
3672409_st -0.8240947 7.068396 -6.385789 0.0001328 0.0220353 1.5371094 — —
TC01002815.hg.1 0.8929899 4.848239 6.382454 0.0001333 0.0220694 1.5333188 TTLL7 tubulin tyrosine ligase-like family, member 7
47420711_st -0.7465450 1.944349 -6.379842 0.0001337 0.0220850 1.5303481 — —
TC06000062.hg.1 0.8658941 5.299124 6.375476 0.0001344 0.0221461 1.5253817 BMP6 bone morphogenetic protein 6
TC09001287.hg.1 0.8107340 7.386857 6.368034 0.0001356 0.0222526 1.5169092 AGTPBP1 ATP/GTP binding protein 1
TC22000139.hg.1 -0.8548400 6.471856 -6.367392 0.0001357 0.0222526 1.5161773 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
47424625_st -1.1335318 3.415271 -6.681419 0.0001458 0.0225897 1.5074103 — —
TC0X002141.hg.1 0.7968700 2.562584 6.357964 0.0001372 0.0224473 1.5054319 RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
TC09000680.hg.1 -1.0235286 2.820390 -6.558142 0.0001443 0.0225897 1.4968504 — —
TC20000968.hg.1 -0.8451528 7.433984 -6.349322 0.0001386 0.0224780 1.4955695 AURKA aurora kinase A
TC04002673.hg.1 0.8113567 5.812093 6.348849 0.0001387 0.0224780 1.4950297 — —
TC02000628.hg.1 -0.8134943 5.703659 -6.348182 0.0001388 0.0224780 1.4942685 SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
TC17000702.hg.1 0.7878023 7.045144 6.346958 0.0001390 0.0224780 1.4928699 SCPEP1 serine carboxypeptidase 1
TC06000657.hg.1 1.1754313 4.978163 6.728576 0.0001501 0.0228092 1.4899254 LOC730101 uncharacterized LOC730101
TC08000788.hg.1 -0.8009179 6.277855 -6.340889 0.0001400 0.0225507 1.4859361 CHRAC1 chromatin accessibility complex 1
TC02004263.hg.1 0.8550858 4.797572 6.339069 0.0001403 0.0225507 1.4838562 FAM161A family with sequence similarity 161, member A
TC08001253.hg.1 0.8771173 4.394583 6.335201 0.0001409 0.0225507 1.4794324 CA8 carbonic anhydrase VIII
TC07002826.hg.1 1.0413314 4.728426 6.474810 0.0001454 0.0225897 1.4773060 KLHL7-AS1 KLHL7 antisense RNA 1 (head to head)
TC01004558.hg.1 -0.6816482 1.705215 -6.333251 0.0001412 0.0225507 1.4772017 RP5-1070A16.1 novel transcript
TC03003091.hg.1 -0.8349747 3.441166 -6.332665 0.0001413 0.0225507 1.4765311 — —
TC03002941.hg.1 0.8734152 4.528359 6.332561 0.0001413 0.0225507 1.4764128 PTPRG-AS1 PTPRG antisense RNA 1
TC12000234.hg.1 0.7900411 9.436170 6.326149 0.0001424 0.0225857 1.4690724 SPX spexin hormone
TC03002832.hg.1 -0.8170220 5.647993 -6.326128 0.0001424 0.0225857 1.4690481 TBC1D5 TBC1 domain family, member 5
TC18000741.hg.1 1.5352322 7.519204 7.624255 0.0001735 0.0235964 1.4685092 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
3670264_st -0.8393577 5.784409 -6.324656 0.0001427 0.0225857 1.4673623 — —
TC0X001197.hg.1 0.9233410 5.216296 6.323576 0.0001428 0.0225857 1.4661262 NAP1L3 nucleosome assembly protein 1-like 3
TC07000707.hg.1 0.9493970 6.649041 6.414826 0.0001460 0.0225897 1.4638581 ZNF277 zinc finger protein 277
TC07002602.hg.1 0.8200867 6.579639 6.320874 0.0001433 0.0225897 1.4630297 — —
TC06002829.hg.1 1.2746738 6.379526 7.028538 0.0001652 0.0232694 1.4502235 EFHC1 EF-hand domain (C-terminal) containing 1
TC01003751.hg.1 -0.7536129 8.580953 -6.309678 0.0001452 0.0225897 1.4501915 NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
TC08001310.hg.1 -0.7953055 6.204316 -6.309063 0.0001453 0.0225897 1.4494856 NCOA2 nuclear receptor coactivator 2
TC02001911.hg.1 0.9636676 4.100054 6.323510 0.0001460 0.0225897 1.4481388 PELI1 pellino E3 ubiquitin protein ligase 1
TC07001605.hg.1 0.8005984 7.404430 6.302173 0.0001465 0.0225897 1.4415742 SAMD9 sterile alpha motif domain containing 9
TC06000978.hg.1 0.8741367 4.925149 6.301449 0.0001466 0.0225897 1.4407423 L3MBTL3 l(3)mbt-like 3 (Drosophila)
TC01003613.hg.1 0.8280757 8.350710 6.300634 0.0001467 0.0225897 1.4398069 RNU6-41P RNA, U6 small nuclear 41, pseudogene
TC10001050.hg.1 -0.7849300 7.026653 -6.299017 0.0001470 0.0225897 1.4379482 SEPHS1 selenophosphate synthetase 1
TC19000429.hg.1 -0.8308621 6.939163 -6.296179 0.0001475 0.0226162 1.4346865 NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19
TC04000881.hg.1 -0.7665194 8.141150 -6.291408 0.0001484 0.0226945 1.4292000 TENM3 teneurin transmembrane protein 3
PSR17016926.hg.1 -0.9035588 9.445533 -6.477488 0.0001547 0.0232164 1.4266238 — —
TC6_mann_hap4000215.hg.1 0.7806525 7.477235 6.286612 0.0001492 0.0227739 1.4236817 MICA MHC class I polypeptide-related sequence A
TC0X000424.hg.1 0.8466126 5.077216 6.283614 0.0001497 0.0228052 1.4202313 ATP7A ATPase, Cu++ transporting, alpha polypeptide
TC07001363.hg.1 -0.7840732 6.561337 -6.279815 0.0001504 0.0228092 1.4158557 TNS3 tensin 3
TC01006052.hg.1 0.8294788 6.837237 6.274788 0.0001513 0.0228673 1.4100629 PLEKHA6 pleckstrin homology domain containing, family A member 6
TC04002799.hg.1 0.8332220 4.655941 6.272789 0.0001516 0.0228673 1.4077585 PDGFC platelet derived growth factor C
TC15000391.hg.1 0.9147848 4.603100 6.272221 0.0001518 0.0228673 1.4071033 SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TC12002894.hg.1 0.7895781 7.081595 6.268690 0.0001524 0.0229140 1.4030316 CALCOCO1 calcium binding and coiled-coil domain 1
TC02001128.hg.1 1.2080262 7.857924 6.922105 0.0001741 0.0235964 1.3934028 NABP1 nucleic acid binding protein 1
TC07000874.hg.1 -0.7825377 2.245862 -6.252201 0.0001554 0.0232664 1.3839895 PP12708 —
TC02004641.hg.1 0.9049147 4.118041 6.248953 0.0001560 0.0232694 1.3802333 CACNB4 calcium channel, voltage-dependent, beta 4 subunit
TC01002892.hg.1 -0.8307453 6.088873 -6.244670 0.0001568 0.0232694 1.3752790 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit
TC14000348.hg.1 0.9727225 5.193360 6.327394 0.0001597 0.0232694 1.3751326 ARID4A AT rich interactive domain 4A (RBP1-like)
TC03003402.hg.1 -0.7763234 7.639378 -6.238826 0.0001579 0.0232694 1.3685146 TM4SF19 transmembrane 4 L six family member 19
TC03001074.hg.1 0.8670309 4.547796 6.225967 0.0001603 0.0232694 1.3536112 LINC00884 long intergenic non-protein coding RNA 884
TC02000608.hg.1 -0.8028716 6.285455 -6.225104 0.0001605 0.0232694 1.3526104 PDCL3 phosducin-like 3
TC14000897.hg.1 0.8197941 3.583013 6.224294 0.0001606 0.0232694 1.3516699 — —
47422105_st -0.8691359 1.358315 -6.508163 0.0001715 0.0234421 1.3467888 — —
TC04000649.hg.1 0.9306334 3.471114 6.230289 0.0001620 0.0232694 1.3456129 LOC101927184 uncharacterized LOC101927184
TC09001261.hg.1 -0.9063579 2.543582 -6.308190 0.0001649 0.0232694 1.3451392 — —
TC09001267.hg.1 -0.9063579 2.543582 -6.308190 0.0001649 0.0232694 1.3451392 — —
TC09001271.hg.1 -0.9063579 2.543582 -6.308190 0.0001649 0.0232694 1.3451392 — —
TC03003151.hg.1 0.8180339 5.113958 6.218481 0.0001617 0.0232694 1.3449233 — —
TC06003411.hg.1 0.8023756 5.561107 6.218387 0.0001618 0.0232694 1.3448144 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
TC11001173.hg.1 -0.7790341 6.941346 -6.211250 0.0001631 0.0232694 1.3365240 DCPS decapping enzyme, scavenger
TC01000128.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-37P RNA, U6 small nuclear 37, pseudogene
TC02002540.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC03000967.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC07001824.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-11P RNA, U6 small nuclear 11, pseudogene
TC0X001437.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC14000206.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-1 RNA, U6 small nuclear 1
TC14001020.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-1 RNA, U6 small nuclear 1
TC15001590.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC19000021.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC19000026.hg.1 0.6902075 10.059433 6.209132 0.0001635 0.0232694 1.3340626 RNU6-2 RNA, U6 small nuclear 2
TC19002500.hg.1 0.7800583 6.974569 6.207260 0.0001639 0.0232694 1.3318867 ETHE1 ethylmalonic encephalopathy 1
3662446_st -0.8625114 7.262263 -6.206738 0.0001640 0.0232694 1.3312793 — —
TC06001548.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_apd_hap1000089.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_dbb_hap3000164.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_mann_hap4000146.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_mcf_hap5000150.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_qbl_hap6000165.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC6_ssto_hap7000144.hg.1 0.9250786 7.339375 6.289130 0.0001686 0.0232694 1.3237456 NEU1 sialidase 1 (lysosomal sialidase)
TC12003272.hg.1 0.8257022 3.990190 6.197579 0.0001658 0.0232694 1.3206231 KLRC2 killer cell lectin-like receptor subfamily C, member 2
TC0X000442.hg.1 1.0835496 4.130368 6.425860 0.0001743 0.0235964 1.3200500 ZNF711 zinc finger protein 711
TC19000805.hg.1 1.0969567 4.332434 6.443537 0.0001753 0.0236042 1.3181819 ERVV-2 endogenous retrovirus group V, member 2
TC08001138.hg.1 0.8388635 4.942103 6.193017 0.0001667 0.0232694 1.3153119 RAB11FIP1 RAB11 family interacting protein 1 (class I)
TC04000611.hg.1 1.5153855 7.685640 7.485131 0.0002058 0.0258355 1.3150324 USP53 ubiquitin specific peptidase 53
TC20000621.hg.1 0.9013200 5.549372 6.191525 0.0001670 0.0232694 1.3135735 JAG1 jagged 1
TC14001578.hg.1 0.8621136 7.414580 6.186626 0.0001680 0.0232694 1.3078644 — —
TC11001686.hg.1 0.7367942 1.717111 6.185168 0.0001683 0.0232694 1.3061647 — —
TC06001769.hg.1 0.8010289 5.486794 6.177163 0.0001699 0.0233421 1.2968259 RP1-8B1.4 novel transcript
TC05000458.hg.1 0.8723092 6.337631 6.176500 0.0001700 0.0233421 1.2960514 ARSK arylsulfatase family, member K
TC01001427.hg.1 0.9089515 3.701087 6.176020 0.0001701 0.0233421 1.2954915 RGS4 regulator of G-protein signaling 4
TC01000704.hg.1 0.8415878 4.042341 6.171968 0.0001710 0.0234098 1.2907608 RNU6-414P RNA, U6 small nuclear 414, pseudogene
TC17000550.hg.1 0.9922196 6.334829 6.356892 0.0001787 0.0236919 1.2879033 — —
TC03001083.hg.1 0.7006451 9.393099 6.156073 0.0001742 0.0235964 1.2721772 RNU6-25P RNA, U6 small nuclear 25, pseudogene
TC08002503.hg.1 1.3055573 3.509722 6.834548 0.0001989 0.0253572 1.2721573 FBXO32 F-box protein 32
TC02000046.hg.1 0.8040990 5.551992 6.155935 0.0001743 0.0235964 1.2720154 ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
TC09000781.hg.1 -0.7648674 7.283637 -6.147618 0.0001760 0.0236042 1.2622763 WDR5 WD repeat domain 5
TC10002146.hg.1 -0.8080162 5.099256 -6.145948 0.0001764 0.0236042 1.2603206 — —
TC04001128.hg.1 0.6916258 9.798247 6.143870 0.0001768 0.0236042 1.2578851 RNU6-32P RNA, U6 small nuclear 32, pseudogene
TC08000390.hg.1 0.6916258 9.798247 6.143870 0.0001768 0.0236042 1.2578851 RNU6-13P RNA, U6 small nuclear 13, pseudogene
TC08000693.hg.1 0.6916258 9.798247 6.143870 0.0001768 0.0236042 1.2578851 RNU6-12P RNA, U6 small nuclear 12, pseudogene
TC11003270.hg.1 0.8701088 5.057714 6.142303 0.0001771 0.0236042 1.2560481 RAB30 RAB30, member RAS oncogene family
TC04001378.hg.1 0.6903876 9.987950 6.141636 0.0001773 0.0236042 1.2552659 RNU6-33P RNA, U6 small nuclear 33, pseudogene
TC03003146.hg.1 0.8204455 3.275715 6.141073 0.0001774 0.0236042 1.2546058 — —
TC08001590.hg.1 0.9455031 4.402599 6.157196 0.0001794 0.0237379 1.2484781 FBXO32 F-box protein 32
TC06002880.hg.1 0.8070056 5.448943 6.135749 0.0001785 0.0236919 1.2483611 MYO6 myosin VI
TC09000934.hg.1 0.9366221 5.389028 6.188372 0.0001817 0.0240014 1.2438370 SCARNA8 small Cajal body-specific RNA 8
TC15000410.hg.1 1.1332729 4.858607 6.474835 0.0001936 0.0249440 1.2421668 TMOD2 tropomodulin 2 (neuronal)
TC12001151.hg.1 -0.8010770 5.430675 -6.118805 0.0001822 0.0240170 1.2284579 CDCA3 cell division cycle associated 3
TC16001861.hg.1 -0.7912799 7.012441 -6.116442 0.0001827 0.0240403 1.2256795 — —
TC0X001419.hg.1 -0.7720865 7.589141 -6.112044 0.0001837 0.0240732 1.2205043 RBMX RNA binding motif protein, X-linked
TC02004703.hg.1 0.7755225 7.337408 6.111683 0.0001838 0.0240732 1.2200796 CHN1 chimerin 1
PSR17013141.hg.1 -0.6524367 10.422445 -6.110662 0.0001840 0.0240732 1.2188784 — —
TC16000660.hg.1 0.8605745 5.482508 6.105596 0.0001851 0.0241534 1.2129135 CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
TC10000099.hg.1 0.6804812 9.884111 6.104820 0.0001853 0.0241534 1.2119985 RNU6-1 RNA, U6 small nuclear 1
TC02004860.hg.1 1.2910890 5.920296 6.836952 0.0002159 0.0263890 1.2050977 — —
TC11002269.hg.1 0.8069522 4.893070 6.091265 0.0001883 0.0244714 1.1960181 EXPH5 exophilin 5
TC12001324.hg.1 0.8607523 4.172550 6.090196 0.0001886 0.0244714 1.1947563 BHLHE41 basic helix-loop-helix family, member e41
47424102_st -0.6607292 1.484512 -6.089368 0.0001888 0.0244714 1.1937785 — —
TC10001744.hg.1 -0.7722290 7.980079 -6.080738 0.0001907 0.0246821 1.1835879 ADAM12 ADAM metallopeptidase domain 12
TC01000772.hg.1 -0.7779901 5.827681 -6.077246 0.0001915 0.0247409 1.1794599 TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae)
TC01004988.hg.1 0.9145245 2.938647 6.154492 0.0001954 0.0250603 1.1780656 CR2 complement component (3d/Epstein Barr virus) receptor 2
TC6_cox_hap2000175.hg.1 0.9170805 7.338070 6.180717 0.0001977 0.0252541 1.1737785 NEU1 sialidase 1 (lysosomal sialidase)
TC07001184.hg.1 1.4508544 4.422780 6.975897 0.0002307 0.0271191 1.1678774 CDCA7L cell division cycle associated 7-like
TC12000406.hg.1 0.8045376 4.039221 6.066684 0.0001940 0.0249440 1.1669659 SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
TC0X000172.hg.1 0.7650966 6.199438 6.065942 0.0001942 0.0249440 1.1660882 RNU6-49P RNA, U6 small nuclear 49, pseudogene
PSR17008064.hg.1 -0.7497554 8.190741 -6.058410 0.0001960 0.0250808 1.1571670 — —
TC08002279.hg.1 1.1508431 5.055110 6.469462 0.0002155 0.0263889 1.1532110 — —
TC17000489.hg.1 -0.9284106 6.623536 -6.172272 0.0002027 0.0256233 1.1515328 MSL1 male-specific lethal 1 homolog (Drosophila)
TC14001079.hg.1 0.9407750 5.816956 6.152314 0.0002038 0.0257085 1.1435919 KLHL28 kelch-like family member 28
PSR04018328.hg.1 -0.6671723 9.973765 -6.044317 0.0001993 0.0253572 1.1404532 — —
TC12000569.hg.1 -0.7029192 9.035384 -6.042899 0.0001997 0.0253572 1.1387693 XPOT exportin, tRNA
TC04001517.hg.1 0.9811845 6.621009 6.239934 0.0002094 0.0259089 1.1376291 BBS7 Bardet-Biedl syndrome 7
TC05002704.hg.1 -0.7767161 9.234008 -6.041891 0.0001999 0.0253572 1.1375729 — —
TC06004073.hg.1 0.7514394 7.152954 6.039917 0.0002004 0.0253723 1.1352287 MICA MHC class I polypeptide-related sequence A
3581324_st -0.9736911 5.122250 -6.157424 0.0002063 0.0258355 1.1347332 — —
TC01002708.hg.1 1.3681070 6.015487 6.929694 0.0002402 0.0277219 1.1292425 JUN jun proto-oncogene
TC01003497.hg.1 0.9555914 6.777789 6.198099 0.0002127 0.0262414 1.1172663 SLC19A2 solute carrier family 19 (thiamine transporter), member 2
TC21000345.hg.1 1.0299759 7.113086 6.326633 0.0002190 0.0264003 1.1164293 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
PSR17013127.hg.1 -0.7684844 9.429407 -6.018788 0.0002056 0.0258355 1.1100988 — —
PSR17013957.hg.1 -0.7691935 6.912605 -6.016337 0.0002062 0.0258355 1.1071794 — —
TC09002604.hg.1 0.8564029 5.135836 6.010014 0.0002078 0.0259089 1.0996438 NMRK1 nicotinamide riboside kinase 1
TC03002106.hg.1 0.8741823 4.255126 6.008783 0.0002081 0.0259089 1.0981762 LEPREL1 leprecan-like 1
TC07001734.hg.1 -0.7486999 6.882906 -6.008038 0.0002083 0.0259089 1.0972870 PUS7 pseudouridylate synthase 7 (putative)
TC07001761.hg.1 0.9576597 4.454658 6.087754 0.0002132 0.0262414 1.0944464 DOCK4 dedicator of cytokinesis 4
3670218_st -0.7268222 9.253683 -6.004871 0.0002091 0.0259089 1.0935094 — —
TC6_cox_hap2000234.hg.1 0.7448214 7.328507 6.004763 0.0002091 0.0259089 1.0933812 MICA MHC class I polypeptide-related sequence A
TC6_ssto_hap7000188.hg.1 0.7448214 7.328507 6.004763 0.0002091 0.0259089 1.0933812 MICA MHC class I polypeptide-related sequence A
TC02002458.hg.1 1.0265021 4.120743 6.181258 0.0002201 0.0264934 1.0861023 CCDC148 coiled-coil domain containing 148
3670208_st -0.6830254 9.687588 -5.988897 0.0002132 0.0262414 1.0744326 — —
TC0X001016.hg.1 0.6799766 9.391945 5.983777 0.0002145 0.0263467 1.0683105 RNU6-29P RNA, U6 small nuclear 29, pseudogene
2839528_st -0.6758431 9.874062 -5.982754 0.0002148 0.0263467 1.0670863 — —
2839515_st -0.7101297 8.561953 -5.975975 0.0002166 0.0264003 1.0589722 — —
TC09000696.hg.1 -0.7853581 8.499060 -5.973336 0.0002173 0.0264003 1.0558119 SET SET nuclear oncogene
TC08002335.hg.1 0.7965139 4.603982 5.973126 0.0002174 0.0264003 1.0555599 PLAG1 pleiomorphic adenoma gene 1
TC19002243.hg.1 -0.7638527 6.658449 -5.972494 0.0002175 0.0264003 1.0548033 U2AF2 U2 small nuclear RNA auxiliary factor 2
TC17002532.hg.1 0.7834372 6.649371 5.968800 0.0002185 0.0264003 1.0503766 CCDC144B coiled-coil domain containing 144B (pseudogene)
TC15001189.hg.1 -0.7818844 5.170014 -5.968622 0.0002186 0.0264003 1.0501632 AVEN apoptosis, caspase activation inhibitor
3670234_st -0.6982206 10.333231 -5.967050 0.0002190 0.0264003 1.0482796 — —
TC19000228.hg.1 0.7481056 6.323005 5.960091 0.0002208 0.0265321 1.0399342 JUNB jun B proto-oncogene
TC21000801.hg.1 -0.7911588 4.796602 -5.955918 0.0002220 0.0266225 1.0349251 — —
TC01005133.hg.1 -0.7860432 4.892716 -5.951916 0.0002231 0.0267077 1.0301201 MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
TC13000855.hg.1 0.7589472 6.042127 5.950227 0.0002235 0.0267176 1.0280911 KDELC1 KDEL (Lys-Asp-Glu-Leu) containing 1
TC19002341.hg.1 0.8158276 4.681387 5.948723 0.0002239 0.0267215 1.0262836 ZNF709 zinc finger protein 709
TC06001088.hg.1 0.7777430 5.179912 5.946794 0.0002245 0.0267394 1.0239664 ULBP2 UL16 binding protein 2
47423158_st -2.2596315 3.663166 -8.585358 0.0003163 0.0331923 1.0224629 — —
TC08000709.hg.1 -0.8044231 5.379164 -5.944439 0.0002251 0.0267714 1.0211348 ZHX2 zinc fingers and homeoboxes 2
TC06001089.hg.1 0.8833559 5.405574 5.951497 0.0002265 0.0268942 1.0174930 ULBP1 UL16 binding protein 1
TC05001418.hg.1 0.7872888 3.038712 5.937952 0.0002269 0.0268942 1.0133331 MAST4-AS1 MAST4 antisense RNA 1
TC01005825.hg.1 0.8732831 4.651250 5.935942 0.0002275 0.0268967 1.0109143 — —
TC16000960.hg.1 -0.7465073 6.235365 -5.935055 0.0002277 0.0268967 1.0098468 COG7 component of oligomeric golgi complex 7
TC02004469.hg.1 -0.7596232 5.994564 -5.933774 0.0002281 0.0268967 1.0083053 — —
PSR02023907.hg.1 -0.7594053 5.699715 -5.927987 0.0002297 0.0270430 1.0013355 — —
TC01002166.hg.1 1.1023211 6.961197 6.399540 0.0002571 0.0290587 0.9977987 ERRFI1 ERBB receptor feedback inhibitor 1
TC0X000911.hg.1 0.7984521 6.849198 5.919186 0.0002322 0.0272457 0.9907269 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
3581363_st -0.7248191 7.796457 -5.913726 0.0002338 0.0273778 0.9841400 — —
TC0X002341.hg.1 0.8455191 4.492786 5.912542 0.0002341 0.0273778 0.9827109 SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1
TC03003320.hg.1 0.8277077 5.750451 5.905986 0.0002360 0.0275536 0.9747933 NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
TC06000747.hg.1 0.7594619 5.577592 5.903709 0.0002366 0.0275851 0.9720431 MYO6 myosin VI
TC08002074.hg.1 0.7747031 3.425062 5.901746 0.0002372 0.0276062 0.9696697 — —
TC02002436.hg.1 -0.7783649 5.078311 -5.897750 0.0002384 0.0276965 0.9648390 AC012501.2 putative novel transcript
TC21000891.hg.1 0.8695222 6.143700 5.933148 0.0002409 0.0277243 0.9639485 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
TC01005709.hg.1 -0.8356774 4.105343 -5.893302 0.0002397 0.0277219 0.9594578 — —
TC15000581.hg.1 0.7286829 7.222950 5.892752 0.0002399 0.0277219 0.9587933 RAB8B RAB8B, member RAS oncogene family
TC05001688.hg.1 0.8635229 4.943385 5.892289 0.0002400 0.0277219 0.9582323 CCDC112 coiled-coil domain containing 112
TC0X001257.hg.1 0.7552662 5.765386 5.888947 0.0002410 0.0277243 0.9541877 MORC4 MORC family CW-type zinc finger 4
TC05001393.hg.1 0.8132856 4.395716 5.886323 0.0002418 0.0277688 0.9510096 ELOVL7 ELOVL fatty acid elongase 7
TC16001433.hg.1 -0.8608740 5.793987 -5.885590 0.0002468 0.0282988 0.9342536 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2
TC09000495.hg.1 -0.8262805 7.312481 -5.866438 0.0002484 0.0284373 0.9248636 ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
TC04001325.hg.1 0.7808751 5.047712 5.858479 0.0002502 0.0285996 0.9172287 PAQR3 progestin and adipoQ receptor family member III
TC12001705.hg.1 0.9994315 4.469713 6.022707 0.0002611 0.0293716 0.9169075 CPM carboxypeptidase M
TC19000711.hg.1 0.7555695 6.484784 5.856015 0.0002510 0.0286204 0.9142340 PPP1R15A protein phosphatase 1, regulatory subunit 15A
TC02000357.hg.1 0.7530791 5.620150 5.855273 0.0002512 0.0286204 0.9133318 B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
3615331_st -0.7383111 6.440903 -5.847997 0.0002535 0.0288325 0.9044814 — —
TC16001990.hg.1 0.7675854 6.395130 5.843423 0.0002549 0.0289495 0.8989132 — —
3670193_st -0.6727677 9.156301 -5.840959 0.0002557 0.0289517 0.8959125 — —
47420823_st -0.6700464 1.895196 -5.840763 0.0002558 0.0289517 0.8956735 — —
3670195_st -0.8252584 6.482494 -5.830622 0.0002590 0.0292239 0.8833133 — —
TC13000431.hg.1 1.0005726 5.205236 6.022876 0.0002738 0.0303415 0.8784774 GAS6-AS2 GAS6 antisense RNA 2 (head to head)
TC10000673.hg.1 0.8242484 5.958795 5.824580 0.0002609 0.0293716 0.8759420 HELLS helicase, lymphoid-specific
TC07000137.hg.1 0.7992565 4.788430 5.819612 0.0002626 0.0294842 0.8698767 IL6 interleukin 6
TC09001482.hg.1 -0.7191760 7.206481 -5.815220 0.0002640 0.0295982 0.8645110 KIAA0368 KIAA0368
47421983_st 0.7532848 2.873791 5.811452 0.0002652 0.0296898 0.8599055 — —
TC04001211.hg.1 -0.7277500 6.457808 -5.807121 0.0002667 0.0298027 0.8546092 CLOCK clock circadian regulator
47423091_st -0.8144015 1.740932 -5.987628 0.0002817 0.0308986 0.8485182 — —
TC15001612.hg.1 0.7494871 5.939014 5.798771 0.0002694 0.0300660 0.8443898 UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
2995641_st -0.9508534 8.169497 -6.044820 0.0002887 0.0312893 0.8400097 — —
TC20001325.hg.1 -0.8385374 5.914300 -5.792259 0.0002723 0.0303234 0.8344237 FAM217B family with sequence similarity 217, member B
TC08001248.hg.1 -0.7869705 8.236273 -5.789382 0.0002726 0.0303234 0.8328855 TOX thymocyte selection-associated high mobility group box
TC07002911.hg.1 0.6546126 1.988247 5.787139 0.0002734 0.0303415 0.8301354 — —
TC0X001817.hg.1 0.7899817 7.218708 5.785113 0.0002741 0.0303415 0.8276505 CXorf57 chromosome X open reading frame 57
TC19002226.hg.1 0.8766628 6.667325 5.872705 0.0002812 0.0308986 0.8262158 ZNF331 zinc finger protein 331
TC01000377.hg.1 0.7389395 6.321245 5.777398 0.0002767 0.0305865 0.8181825 SESN2 sestrin 2
TC10000148.hg.1 0.6305846 10.067894 5.772415 0.0002784 0.0307290 0.8120630 RNU6-15P RNA, U6 small nuclear 15, pseudogene
TC20000956.hg.1 0.7172982 6.808577 5.770804 0.0002790 0.0307427 0.8100837 ZNF217 zinc finger protein 217
TC10000002.hg.1 -0.7267605 7.046912 -5.763503 0.0002815 0.0308986 0.8011073 ZMYND11 zinc finger, MYND-type containing 11
TC04001940.hg.1 -0.7583076 3.182329 -5.761361 0.0002823 0.0309140 0.7984720 — —
TC01001934.hg.1 -0.7673371 6.570784 -5.759512 0.0002830 0.0309259 0.7961979 COA6 cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)
3672401_st -0.7193834 6.554615 -5.758570 0.0002833 0.0309259 0.7950383 — —
TC02001388.hg.1 0.7636758 5.193729 5.754346 0.0002848 0.0310165 0.7898383 ARMC9 armadillo repeat containing 9
TC16000209.hg.1 -0.7229097 6.312844 -5.753753 0.0002850 0.0310165 0.7891080 COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
TC07003301.hg.1 0.7320708 7.099435 5.749509 0.0002865 0.0311335 0.7838800 PNPLA8 patatin-like phospholipase domain containing 8
TC09002195.hg.1 -0.8323735 3.822080 -5.743059 0.0002888 0.0312893 0.7759294 ZNF618 zinc finger protein 618
TC01002884.hg.1 0.9466535 5.919200 5.913666 0.0003040 0.0324868 0.7718806 ARHGAP29 Rho GTPase activating protein 29
TC04002090.hg.1 -0.7228280 6.883279 -5.737414 0.0002909 0.0314277 0.7689671 — —
TC17001370.hg.1 0.7896186 5.849923 5.737082 0.0002910 0.0314277 0.7685565 SLFN12 schlafen family member 12
TC03000624.hg.1 0.9431567 4.202349 5.847056 0.0003015 0.0322642 0.7645122 EAF2 ELL associated factor 2
TC20001764.hg.1 0.8739477 4.597613 5.741311 0.0002936 0.0316595 0.7623917 SEMG1 semenogelin I
TC16001872.hg.1 -0.7363164 7.977771 -5.726625 0.0002948 0.0317148 0.7556440 — —
TC13001318.hg.1 -0.7100196 8.351679 -5.725493 0.0002953 0.0317148 0.7542451 TFDP1 transcription factor Dp-1
TC12002878.hg.1 0.7733492 6.565850 5.724948 0.0002955 0.0317148 0.7535719 CSRNP2 cysteine-serine-rich nuclear protein 2
TC06001123.hg.1 -0.7407793 5.417190 -5.717443 0.0002983 0.0319661 0.7442911 ARID1B AT rich interactive domain 1B (SWI1-like)
TC05000184.hg.1 0.9937318 5.742348 5.957588 0.0003243 0.0337321 0.7289573 PTGER4 prostaglandin E receptor 4 (subtype EP4)
TC02001943.hg.1 0.9246995 5.318194 5.827310 0.0003144 0.0331013 0.7265318 FBXO48 F-box protein 48
3371080_st -0.7727050 2.754444 -5.695083 0.0003067 0.0326806 0.7165920 — —
TC22000728.hg.1 -0.7886213 4.184480 -5.695022 0.0003068 0.0326806 0.7165154 — —
TC17002366.hg.1 -0.7496912 6.427590 -5.693010 0.0003075 0.0327139 0.7140200 UNK unkempt family zinc finger
TC03002737.hg.1 0.7847330 4.225084 5.689708 0.0003088 0.0328007 0.7099214 LINC00884 long intergenic non-protein coding RNA 884
TC22000381.hg.1 0.7672600 5.258074 5.686269 0.0003102 0.0328934 0.7056507 — —
TC12001106.hg.1 -1.0446382 8.083244 -6.144591 0.0003502 0.0348732 0.7031235 FOXM1 forkhead box M1
TC01000619.hg.1 -0.7268537 5.816805 -5.683984 0.0003111 0.0329387 0.7028124 CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
TC07000159.hg.1 0.7257104 6.977594 5.682076 0.0003118 0.0329684 0.7004430 NFE2L3 nuclear factor, erythroid 2-like 3
47419401_st -0.6277635 1.950194 -5.676964 0.0003138 0.0331013 0.6940889 — —
TC0X000515.hg.1 0.7068816 6.849945 5.675322 0.0003145 0.0331013 0.6920466 — —
TC15000945.hg.1 1.0697486 5.443667 6.047407 0.0003472 0.0347302 0.6918025 ARRDC4 arrestin domain containing 4
TC12000757.hg.1 0.6425029 9.978124 5.671278 0.0003161 0.0331923 0.6870160 RNU6-36P RNA, U6 small nuclear 36, pseudogene
TC18000240.hg.1 0.6538935 9.918933 5.665541 0.0003184 0.0333627 0.6798757 RNU6-39P RNA, U6 small nuclear 39, pseudogene
TC18000187.hg.1 0.7329503 7.582946 5.663821 0.0003191 0.0333856 0.6777330 C18orf54 chromosome 18 open reading frame 54
TC10000636.hg.1 1.0137751 5.150534 5.913426 0.0003444 0.0346800 0.6715911 IFIT2 interferon-induced protein with tetratricopeptide repeats 2
TC01003044.hg.1 -0.7732568 5.999274 -5.658111 0.0003214 0.0335650 0.6706193 WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
TC20000819.hg.1 -0.7158801 6.064780 -5.657227 0.0003217 0.0335650 0.6695179 SOGA1 suppressor of glucose, autophagy associated 1
TC03003398.hg.1 0.7314411 6.189643 5.652313 0.0003237 0.0337242 0.6633906 IFT80 intraflagellar transport 80 homolog (Chlamydomonas)
TC17002246.hg.1 -0.7170495 3.012189 -5.649793 0.0003248 0.0337321 0.6602471 — —
TC03001570.hg.1 0.8151761 6.299492 5.656806 0.0003279 0.0340085 0.6542012 ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
TC07003396.hg.1 -0.7106712 6.725415 -5.637553 0.0003298 0.0341577 0.6449652 TRRAP transformation/transcription domain-associated protein
TC11000720.hg.1 0.7602140 7.131396 5.635929 0.0003305 0.0341778 0.6429363 RNU6-1175P RNA, U6 small nuclear 1175, pseudogene
TC03000836.hg.1 0.6778435 2.257730 5.633188 0.0003317 0.0342464 0.6395094 RP11-38P22.2 novel transcript
PSR17016929.hg.1 -1.0500264 9.866775 -6.298454 0.0003922 0.0373455 0.6387092 — —
TC12001751.hg.1 0.9420094 4.901291 5.774291 0.0003462 0.0346800 0.6376465 PHLDA1 pleckstrin homology-like domain, family A, member 1
TC09000560.hg.1 0.6506910 9.069329 5.630957 0.0003326 0.0342931 0.6367203 UGCG UDP-glucose ceramide glucosyltransferase
TC07002600.hg.1 0.7437995 3.792856 5.626396 0.0003345 0.0344414 0.6310146 AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
TC15000348.hg.1 0.7140959 7.869614 5.621868 0.0003365 0.0345891 0.6253476 RNU6-1332P RNA, U6 small nuclear 1332, pseudogene
TC01003084.hg.1 0.7562335 5.077340 5.618804 0.0003378 0.0346389 0.6215112 — —
TC15000701.hg.1 0.6784102 8.781960 5.618160 0.0003380 0.0346389 0.6207049 — —
PSR17008082.hg.1 -0.6863690 7.882351 -5.615236 0.0003393 0.0346389 0.6170415 — —
TC18000218.hg.1 0.6520072 9.377676 5.615128 0.0003393 0.0346389 0.6169057 RNU6-116P RNA, U6 small nuclear 116, pseudogene
TC10001505.hg.1 0.7321572 5.316882 5.615007 0.0003394 0.0346389 0.6167547 LIPA lipase A, lysosomal acid, cholesterol esterase
47420867_st -0.7756056 3.334404 -5.613430 0.0003401 0.0346582 0.6147778 — —
TC15000611.hg.1 -0.7733815 5.686940 -5.610915 0.0003412 0.0346800 0.6116254 DIS3L DIS3 like exosome 3-5 exoribonuclease
TC19002567.hg.1 1.0105337 6.334690 5.944069 0.0003777 0.0365987 0.6038380 ZNF600 zinc finger protein 600
TC01002618.hg.1 -0.7132200 5.845326 -5.602686 0.0003448 0.0346800 0.6013047 LRRC41 leucine rich repeat containing 41
TC04001370.hg.1 0.7654106 6.290996 5.600999 0.0003455 0.0346800 0.5991866 ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2
TC20000106.hg.1 0.6929306 8.000357 5.600803 0.0003456 0.0346800 0.5989415 RNU6-27P RNA, U6 small nuclear 27, pseudogene
TC03002386.hg.1 -0.6768237 2.082288 -5.600583 0.0003457 0.0346800 0.5986645 — —
TC06000375.hg.1 0.7270503 6.732309 5.599553 0.0003461 0.0346800 0.5973714 SNORA38 small nucleolar RNA, H/ACA box 38
TC6_cox_hap2000071.hg.1 0.7270503 6.732309 5.599553 0.0003461 0.0346800 0.5973714 SNORA38 small nucleolar RNA, H/ACA box 38
TC6_mann_hap4000062.hg.1 0.7270503 6.732309 5.599553 0.0003461 0.0346800 0.5973714 SNORA38 small nucleolar RNA, H/ACA box 38
TC6_qbl_hap6000062.hg.1 0.7270503 6.732309 5.599553 0.0003461 0.0346800 0.5973714 SNORA38 small nucleolar RNA, H/ACA box 38
TC6_ssto_hap7000058.hg.1 0.7270503 6.732309 5.599553 0.0003461 0.0346800 0.5973714 SNORA38 small nucleolar RNA, H/ACA box 38
TC19001806.hg.1 0.8584646 8.706335 5.763790 0.0003669 0.0360882 0.5888270 ZNF468 zinc finger protein 468
TC11002832.hg.1 0.7034613 7.763544 5.592305 0.0003493 0.0348732 0.5882688 — —
TC07003027.hg.1 -0.7223177 7.521138 -5.590947 0.0003499 0.0348732 0.5865617 LOC100093631 general transcription factor II, i, pseudogene
TC04000569.hg.1 0.7372118 5.933097 5.589458 0.0003506 0.0348732 0.5846906 RNU6-35P RNA, U6 small nuclear 35, pseudogene
TC17002107.hg.1 0.7443815 5.935505 5.586221 0.0003520 0.0349678 0.5806207 CCDC144CP coiled-coil domain containing 144C, pseudogene
TC04002614.hg.1 1.2441502 7.094855 6.351331 0.0004270 0.0390550 0.5788604 THAP9-AS1 THAP9 antisense RNA 1
TC03002656.hg.1 0.8324489 4.648974 5.580378 0.0003547 0.0351794 0.5732700 SKIL SKI-like proto-oncogene
TC09001343.hg.1 1.0436360 6.427102 5.986968 0.0003986 0.0374049 0.5690524 — —
TC10001535.hg.1 -0.6830156 7.945867 -5.575104 0.0003571 0.0353667 0.5666311 MYOF myoferlin
TC01000729.hg.1 0.7558668 6.234159 5.573851 0.0003576 0.0353736 0.5650531 DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
TC03000814.hg.1 0.7337817 7.878897 5.564137 0.0003621 0.0357642 0.5528111 TSC22D2 TSC22 domain family, member 2
TC0Y000233.hg.1 0.7367356 3.972672 5.559468 0.0003643 0.0359276 0.5469231 — —
TC05000462.hg.1 1.0441869 4.754120 5.863672 0.0003975 0.0373767 0.5463733 C5orf27 chromosome 5 open reading frame 27
TC0X000188.hg.1 -0.7277997 6.121591 -5.555139 0.0003663 0.0360763 0.5414588 — —
TC11000956.hg.1 1.8628150 6.661703 7.570414 0.0005357 0.0442035 0.5353362 BIRC3 baculoviral IAP repeat containing 3
TC06001326.hg.1 0.7392370 4.453129 5.549093 0.0003691 0.0362546 0.5338243 KIAA0319 KIAA0319
TC01003286.hg.1 0.7565328 2.534339 5.542760 0.0003721 0.0364527 0.5258208 RNU6-179P RNA, U6 small nuclear 179, pseudogene
TC10002885.hg.1 -0.8497464 7.820410 -5.669281 0.0003865 0.0370884 0.5258015 — —
TC08000647.hg.1 0.7470687 8.290776 5.542654 0.0003722 0.0364527 0.5256869 RNU6-1011P RNA, U6 small nuclear 1011, pseudogene
TC01003185.hg.1 0.8340929 4.834406 5.542070 0.0003733 0.0365135 0.5231115 — —
47422984_st -0.8135249 2.722691 -5.601314 0.0003805 0.0367609 0.5222381 — —
TC04002346.hg.1 -0.7039452 8.350223 -5.539079 0.0003739 0.0365183 0.5211652 TENM3 teneurin transmembrane protein 3
TC06002022.hg.1 0.7523963 4.760957 5.536406 0.0003751 0.0365679 0.5177833 FYN FYN proto-oncogene, Src family tyrosine kinase
TC02002430.hg.1 0.7280151 5.070479 5.535533 0.0003756 0.0365679 0.5166797 CACNB4 calcium channel, voltage-dependent, beta 4 subunit
TC6_mann_hap4000216.hg.1 0.7144928 8.110210 5.534776 0.0003759 0.0365679 0.5157214 MICB MHC class I polypeptide-related sequence B
PSR17008080.hg.1 -0.6819098 7.648125 -5.530918 0.0003778 0.0365987 0.5108370 — —
TC02003138.hg.1 0.6386630 9.240613 5.530893 0.0003778 0.0365987 0.5108063 YPEL5 yippee-like 5 (Drosophila)
TC02001690.hg.1 0.6998004 2.885208 5.526009 0.0003802 0.0367609 0.5046194 — —
TC10000550.hg.1 -0.9341612 4.851915 -5.666294 0.0003975 0.0373767 0.5028436 — —
TC08001850.hg.1 -0.6949507 6.605105 -5.524229 0.0003810 0.0367609 0.5023641 PTK2B protein tyrosine kinase 2 beta
TC18000522.hg.1 0.6719114 8.128173 5.522215 0.0003820 0.0368055 0.4998124 SNORA37 small nucleolar RNA, H/ACA box 37
PSR17008061.hg.1 -0.6645217 8.294793 -5.520137 0.0003830 0.0368534 0.4971773 — —
TC05002062.hg.1 0.7116420 6.081620 5.518843 0.0003837 0.0368642 0.4955366 SH3PXD2B SH3 and PX domains 2B
TC07002793.hg.1 0.9951520 5.231137 5.770715 0.0004145 0.0383141 0.4928906 — —
TC03000632.hg.1 -0.6962182 7.272123 -5.511965 0.0003871 0.0370897 0.4868122 DTX3L deltex 3 like, E3 ubiquitin ligase
TC01003614.hg.1 0.6983554 5.958164 5.509148 0.0003885 0.0371735 0.4832360 NMNAT2 nicotinamide nucleotide adenylyltransferase 2
TC17002317.hg.1 0.7294064 3.834452 5.507579 0.0003893 0.0371867 0.4812437 — —
TC15002760.hg.1 -0.6929854 7.163482 -5.506761 0.0003897 0.0371867 0.4802049 ARHGAP11B Rho GTPase activating protein 11B
TC17001263.hg.1 -0.7431620 8.368163 -5.501337 0.0003924 0.0373455 0.4733148 USP22 ubiquitin specific peptidase 22
TC10000801.hg.1 0.7796438 5.965823 5.500048 0.0003930 0.0373569 0.4716758 DUSP5 dual specificity phosphatase 5
TC22001157.hg.1 -0.7673856 5.962739 -5.495948 0.0003951 0.0373767 0.4664635 — —
TC06001955.hg.1 0.7350681 4.857947 5.494660 0.0003958 0.0373767 0.4648256 GPR63 G protein-coupled receptor 63
TC03001624.hg.1 0.6943105 6.067247 5.494074 0.0003961 0.0373767 0.4640800 CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
TC19001967.hg.1 -0.7402085 7.636963 -5.492946 0.0003967 0.0373767 0.4626450 RAB11B RAB11B, member RAS oncogene family
TC06000640.hg.1 0.7672901 6.019079 5.491466 0.0003974 0.0373767 0.4607630 CENPQ centromere protein Q
2960249_st -0.7485832 3.747535 -5.491457 0.0003974 0.0373767 0.4607512 — —
3670214_st -0.7314855 8.888415 -5.495214 0.0003989 0.0374049 0.4588183 — —
47420802_st -0.9725349 1.295716 -6.153932 0.0004760 0.0412875 0.4581020 — —
TC03001047.hg.1 0.8042189 4.732478 5.482052 0.0004022 0.0376728 0.4487785 IL1RAP interleukin 1 receptor accessory protein
TC04000075.hg.1 -0.7092415 7.305822 -5.479620 0.0004035 0.0377409 0.4456796 TBC1D14 TBC1 domain family, member 14
TC02000748.hg.1 0.7302508 6.615530 5.474597 0.0004061 0.0379354 0.4392776 INSIG2 insulin induced gene 2
TC15001667.hg.1 -0.6844846 6.514600 -5.471015 0.0004080 0.0380605 0.4347089 PTPN9 protein tyrosine phosphatase, non-receptor type 9
TC07001858.hg.1 0.7247801 7.250901 5.466108 0.0004106 0.0382514 0.4284478 UBE2H ubiquitin-conjugating enzyme E2H
TC07002985.hg.1 0.7129653 6.832955 5.464046 0.0004117 0.0382573 0.4258161 ZNF117 zinc finger protein 117
TC06001400.hg.1 0.7438141 4.749608 5.463941 0.0004117 0.0382573 0.4256812 ZNF204P zinc finger protein 204, pseudogene
TC07000971.hg.1 0.7557806 5.571279 5.462539 0.0004125 0.0382761 0.4238918 RNY5 RNA, Ro-associated Y5
PSR12005973.hg.1 -0.5867126 10.665717 -5.460248 0.0004137 0.0383141 0.4209657 — —
TC10002643.hg.1 -0.7828985 4.206689 -5.459153 0.0004143 0.0383141 0.4195669 A1CF APOBEC1 complementation factor
TC19002572.hg.1 0.8681268 7.225062 5.601115 0.0004351 0.0394997 0.4156412 ZNF160 zinc finger protein 160
TC12003131.hg.1 -0.6867045 8.262518 -5.454152 0.0004170 0.0384900 0.4131768 CLIP1 CAP-GLY domain containing linker protein 1
TC08000545.hg.1 0.6972675 8.618341 5.450239 0.0004191 0.0386344 0.4081738 RIPK2 receptor-interacting serine-threonine kinase 2
TC10002067.hg.1 -0.7086050 2.027936 -5.474314 0.0004242 0.0389728 0.4046481 — —
TC01002195.hg.1 -0.7440525 8.031792 -5.444794 0.0004220 0.0388563 0.4012086 SRM spermidine synthase
PSR17016932.hg.1 -0.7146260 9.908902 -5.504147 0.0004334 0.0394853 0.3952960 — —
TC15000279.hg.1 0.8033851 4.806394 5.439836 0.0004248 0.0389728 0.3948610 LINC00984 long intergenic non-protein coding RNA 984
PSR04018301.hg.1 -0.7432946 5.186648 -5.438781 0.0004253 0.0389728 0.3935099 — —
TC03002739.hg.1 0.7087258 6.873384 5.438448 0.0004255 0.0389728 0.3930848 — —
TC07002222.hg.1 1.9468190 5.488268 7.477693 0.0006354 0.0479290 0.3892360 CREB5 cAMP responsive element binding protein 5
TC20000582.hg.1 0.7398803 5.307251 5.431460 0.0004294 0.0392203 0.3841310 RNF24 ring finger protein 24
TC12001393.hg.1 0.7612940 5.839445 5.430548 0.0004299 0.0392203 0.3829619 SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13
TC10000979.hg.1 0.8415621 7.578248 5.549909 0.0004510 0.0400544 0.3750092 KLF6 Kruppel-like factor 6
TC01000987.hg.1 0.6812688 6.967639 5.420508 0.0004355 0.0394997 0.3700831 CTTNBP2NL CTTNBP2 N-terminal like
TC03000419.hg.1 0.7761853 5.011619 5.420445 0.0004356 0.0394997 0.3700026 MITF microphthalmia-associated transcription factor
TC15001668.hg.1 -0.6895220 6.910496 -5.419532 0.0004361 0.0394997 0.3688302 SNUPN snurportin 1
TC0X001836.hg.1 -0.6495086 2.372587 -5.419096 0.0004363 0.0394997 0.3682703 — —
TC12001803.hg.1 0.7021768 5.592219 5.411495 0.0004406 0.0397911 0.3585085 LUM lumican
TC11000580.hg.1 0.6970598 7.239100 5.410604 0.0004411 0.0397911 0.3573636 RNU6-45P RNA, U6 small nuclear 45, pseudogene
PSR17013102.hg.1 -0.6652450 7.627404 -5.410460 0.0004412 0.0397911 0.3571787 — —
TC09000999.hg.1 1.1830701 6.057024 6.048783 0.0005277 0.0439869 0.3565262 DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
TC08000700.hg.1 0.7204365 4.268152 5.407691 0.0004428 0.0398833 0.3536197 COL14A1 collagen, type XIV, alpha 1
TC11003331.hg.1 0.7226234 4.876086 5.405656 0.0004440 0.0399050 0.3510027 EXPH5 exophilin 5
TC03002936.hg.1 -0.6339352 1.949066 -5.405305 0.0004442 0.0399050 0.3505518 — —
TC14001370.hg.1 0.7362067 5.920962 5.403910 0.0004450 0.0399265 0.3487580 STON2 stonin 2
TC16001270.hg.1 -0.7056125 5.818315 -5.402773 0.0004456 0.0399347 0.3472954 MLKL mixed lineage kinase domain-like
TC11003329.hg.1 0.7960132 6.883468 5.457862 0.0004555 0.0402647 0.3441656 NPAT nuclear protein, ataxia-telangiectasia locus
2839538_st -0.6077333 9.712720 -5.398102 0.0004484 0.0400544 0.3412856 — —
TC15000633.hg.1 0.7470489 6.783702 5.395710 0.0004498 0.0400544 0.3382063 GLCE glucuronic acid epimerase
TC11003466.hg.1 0.6688664 2.589277 5.394884 0.0004502 0.0400544 0.3371426 BCO2 beta-carotene oxygenase 2
TC03000835.hg.1 0.7320515 4.606913 5.394639 0.0004504 0.0400544 0.3368272 P2RY1 purinergic receptor P2Y, G-protein coupled, 1
TC06000468.hg.1 -0.6669244 2.397823 -5.394375 0.0004505 0.0400544 0.3364872 — —
TC04000585.hg.1 0.6487674 2.462329 5.394044 0.0004507 0.0400544 0.3360614 — —
TC01003974.hg.1 0.7305543 4.037078 5.391219 0.0004524 0.0400987 0.3324222 SIPA1L2 signal-induced proliferation-associated 1 like 2
TC11000412.hg.1 -0.7034745 6.717872 -5.390863 0.0004526 0.0400987 0.3319643 PTPRJ protein tyrosine phosphatase, receptor type, J
TC17000728.hg.1 1.2344796 4.156853 6.023481 0.0005410 0.0442913 0.3318508 MIR21 microRNA 21
TC08000571.hg.1 0.7800276 8.400241 5.455095 0.0004653 0.0407377 0.3266852 PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
TC08001120.hg.1 0.7479245 5.365815 5.384438 0.0004564 0.0402647 0.3236842 RNF122 ring finger protein 122
TC06001509.hg.1 0.6247610 2.014744 5.383854 0.0004567 0.0402647 0.3229309 — —
TC04000274.hg.1 0.7273332 7.241646 5.383829 0.0004568 0.0402647 0.3228992 ATP10D ATPase, class V, type 10D
TC12000054.hg.1 -0.5454149 1.191052 -5.378161 0.0004601 0.0404857 0.3155887 — —
TC07000969.hg.1 -0.6701616 8.095978 -5.377704 0.0004604 0.0404857 0.3149994 CUL1 cullin 1
TC0X000222.hg.1 0.6654374 7.185481 5.375251 0.0004619 0.0405646 0.3118333 RP2 retinitis pigmentosa 2 (X-linked recessive)
TC06000655.hg.1 1.0125933 5.579815 5.715702 0.0005129 0.0433147 0.3115203 EFHC1 EF-hand domain (C-terminal) containing 1
TC07000307.hg.1 0.6698822 7.029804 5.373866 0.0004627 0.0405872 0.3100461 UPP1 uridine phosphorylase 1
TC14001127.hg.1 0.7142719 4.206589 5.368945 0.0004657 0.0407377 0.3036920 TRIM9 tripartite motif containing 9
2909162_st -0.6658809 7.703047 -5.368165 0.0004662 0.0407377 0.3026845 — —
TC05002340.hg.1 0.6482976 2.417323 5.365918 0.0004675 0.0408067 0.2997802 — —
TC04002310.hg.1 0.7311832 2.793388 5.364369 0.0004685 0.0408386 0.2977792 — —
TC09000916.hg.1 -0.6810496 7.332738 -5.359165 0.0004717 0.0410613 0.2910519 NFIB nuclear factor I/B
TC04001174.hg.1 0.7241454 4.012537 5.358304 0.0004722 0.0410613 0.2899378 RNU6-838P RNA, U6 small nuclear 838, pseudogene
TC20000642.hg.1 0.9138778 2.736411 5.593326 0.0005091 0.0431745 0.2894815 FLRT3 fibronectin leucine rich transmembrane protein 3
TC22000571.hg.1 -0.8898834 2.152323 -5.693143 0.0005259 0.0439869 0.2865335 — —
TC0X000472.hg.1 0.6681149 7.091565 5.355650 0.0004738 0.0411529 0.2865045 — —
TC12000585.hg.1 0.7127530 3.717153 5.348444 0.0004783 0.0413818 0.2771785 — —
TC01005279.hg.1 0.7878105 5.097443 5.348301 0.0004784 0.0413818 0.2769928 — —
TC01001050.hg.1 0.6917360 9.265268 5.347635 0.0004788 0.0413818 0.2761307 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
47421979_st 0.8091825 3.336698 5.369398 0.0004859 0.0417898 0.2703524 — —
TC03000479.hg.1 0.7861708 5.894436 5.359686 0.0004844 0.0417635 0.2701886 ARL6 ADP-ribosylation factor-like 6
TC10001701.hg.1 -0.6671691 6.769607 -5.342933 0.0004818 0.0415858 0.2700392 SFXN4 sideroflexin 4
3670228_st -0.6311862 10.617707 -5.336385 0.0004859 0.0417898 0.2615509 — —
TC15000433.hg.1 0.8592470 4.123583 5.403997 0.0005008 0.0429122 0.2556504 TEX9 testis expressed 9
TC09001540.hg.1 -0.6909695 5.693262 -5.321549 0.0004954 0.0425569 0.2422951 PHF19 PHD finger protein 19
TC0X001752.hg.1 -0.6709753 7.250297 -5.317949 0.0004978 0.0427061 0.2376166 MED12 mediator complex subunit 12
TC11000482.hg.1 0.7801424 7.223166 5.369454 0.0005097 0.0431745 0.2328129 FAM111B family with sequence similarity 111, member B
TC0X000872.hg.1 1.1000626 5.887803 5.822139 0.0005848 0.0460258 0.2303104 FANCB Fanconi anemia, complementation group B
PSR16019785.hg.1 -0.5550467 10.727039 -5.311092 0.0005023 0.0429579 0.2287017 — —
TC17000396.hg.1 0.6894190 6.813506 5.310683 0.0005025 0.0429579 0.2281692 SLFN5 schlafen family member 5
TC08001399.hg.1 0.7033801 4.969504 5.307422 0.0005047 0.0430897 0.2239258 RNU6-925P RNA, U6 small nuclear 925, pseudogene
TC18000100.hg.1 0.6647839 8.661406 5.306459 0.0005053 0.0430920 0.2226728 RIOK3 RIO kinase 3
TC11000809.hg.1 -0.6815911 6.440725 -5.305017 0.0005063 0.0431214 0.2207953 SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
TC02000183.hg.1 0.7236798 5.942075 5.304029 0.0005069 0.0431253 0.2195099 FOSL2 FOS-like antigen 2
TC08001549.hg.1 0.9094152 4.853946 5.448117 0.0005319 0.0442035 0.2194522 — —
TC04001688.hg.1 0.6999942 5.363471 5.300829 0.0005091 0.0431745 0.2153432 RNU6-128P RNA, U6 small nuclear 128, pseudogene
PSR04018304.hg.1 -0.7361363 6.601280 -5.299297 0.0005101 0.0431745 0.2133474 — —
TC18000202.hg.1 1.1385932 7.238020 5.919651 0.0006126 0.0472346 0.2131424 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
TC09002909.hg.1 -0.6741538 7.277860 -5.298578 0.0005106 0.0431745 0.2124100 NUP188 nucleoporin 188kDa
TC05000664.hg.1 -0.7169951 6.287288 -5.293113 0.0005143 0.0433814 0.2052882 JADE2 jade family PHD finger 2
TC02004675.hg.1 0.7587974 1.927830 5.442520 0.0005414 0.0442913 0.2041695 SCN9A sodium channel, voltage-gated, type IX, alpha subunit
TC04001397.hg.1 0.6239772 8.897339 5.292052 0.0005150 0.0433899 0.2039054 RNU6-34P RNA, U6 small nuclear 34, pseudogene
TC02002166.hg.1 -0.6576997 6.784451 -5.290655 0.0005159 0.0434178 0.2020842 TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TC01002616.hg.1 0.6850081 5.519958 5.289222 0.0005169 0.0434478 0.2002148 PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PSR17016933.hg.1 -0.7340519 8.897056 -5.346582 0.0005273 0.0439869 0.2000982 — —
TC01001378.hg.1 -0.6776614 6.985387 -5.285211 0.0005196 0.0436254 0.1949825 UFC1 ubiquitin-fold modifier conjugating enzyme 1
TC08001511.hg.1 0.7419399 6.413635 5.282653 0.0005214 0.0437203 0.1916437 LRP12 low density lipoprotein receptor-related protein 12
TC18000246.hg.1 -0.6483234 7.689765 -5.278597 0.0005242 0.0439020 0.1863482 TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast)
PSR04018330.hg.1 -0.6729372 8.197176 -5.274728 0.0005268 0.0439869 0.1812949 — —
PSR17008083.hg.1 -0.7243291 4.615975 -5.267066 0.0005322 0.0442035 0.1712792 — —
TC01003327.hg.1 0.9804897 7.129665 5.643758 0.0006025 0.0469013 0.1680287 SCARNA4 small Cajal body-specific RNA 4
TC11003304.hg.1 -0.6970825 3.294207 -5.264548 0.0005339 0.0442035 0.1679854 — —
3670204_st -0.5894090 10.052455 -5.263998 0.0005343 0.0442035 0.1672653 — —
3670248_st -0.6008015 9.795011 -5.263414 0.0005347 0.0442035 0.1665025 — —
TC01004674.hg.1 0.6837347 9.147621 5.263148 0.0005349 0.0442035 0.1661536 — —
TC07001193.hg.1 0.7405416 5.037515 5.262473 0.0005354 0.0442035 0.1652710 KLHL7-AS1 KLHL7 antisense RNA 1 (head to head)
TC11002664.hg.1 -0.6985874 4.691751 -5.261762 0.0005359 0.0442035 0.1643409 PTPRJ protein tyrosine phosphatase, receptor type, J
TC08000326.hg.1 0.7040726 5.627653 5.258742 0.0005380 0.0442913 0.1603880 POLB polymerase (DNA directed), beta
PSR12005970.hg.1 -0.5265634 11.595743 -5.257166 0.0005392 0.0442913 0.1583240 — —
TC10000350.hg.1 1.0021476 9.165609 5.791213 0.0006365 0.0479538 0.1568476 DKK1 dickkopf WNT signaling pathway inhibitor 1
TC03003286.hg.1 -0.7275355 3.545942 -5.256015 0.0005400 0.0442913 0.1568176 — —
TC0X000517.hg.1 0.6703096 6.226476 5.255979 0.0005400 0.0442913 0.1567705 CXorf57 chromosome X open reading frame 57
TC16000223.hg.1 0.7558860 3.644948 5.254614 0.0005410 0.0442913 0.1549820 ACSM3 acyl-CoA synthetase medium-chain family member 3
3670220_st -0.6703555 9.435371 -5.251913 0.0005429 0.0443662 0.1514446 — —
TC11002727.hg.1 0.8109395 8.337436 5.381948 0.0005690 0.0453330 0.1496139 NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
TC01001186.hg.1 -0.6883879 6.989413 -5.249492 0.0005447 0.0444566 0.1482715 RPRD2 regulation of nuclear pre-mRNA domain containing 2
TC08000809.hg.1 -0.6585153 6.446792 -5.247535 0.0005461 0.0444773 0.1457062 LY6K lymphocyte antigen 6 complex, locus K
TC08000695.hg.1 0.6358050 8.141492 5.246628 0.0005467 0.0444773 0.1445176 MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene)
TC0X000530.hg.1 0.6705472 6.557116 5.246174 0.0005470 0.0444773 0.1439224 ATG4A autophagy related 4A, cysteine peptidase
TC04001516.hg.1 -0.6475954 9.331232 -5.245620 0.0005474 0.0444773 0.1431967 CCNA2 cyclin A2
PSR17013108.hg.1 -0.6381416 9.226407 -5.244768 0.0005481 0.0444773 0.1420795 — —
TC05000999.hg.1 -0.6268768 8.492043 -5.243840 0.0005487 0.0444807 0.1408617 HIGD2A HIG1 hypoxia inducible domain family, member 2A
3672403_st -0.6077609 9.783228 -5.241047 0.0005508 0.0445937 0.1371992 — —
TC17000752.hg.1 0.8537198 2.400141 5.462901 0.0005936 0.0464136 0.1368287 — —
TC17001046.hg.1 0.8537198 2.400141 5.462901 0.0005936 0.0464136 0.1368287 — —
TC6_ssto_hap7000189.hg.1 0.6552772 8.117950 5.236969 0.0005537 0.0447565 0.1318481 MICB MHC class I polypeptide-related sequence B
TC16001156.hg.1 0.6129997 9.091417 5.236554 0.0005540 0.0447565 0.1313028 SNORA76A small nucleolar RNA, H/ACA box 76A
TC12000159.hg.1 0.6503148 7.307374 5.231865 0.0005575 0.0449316 0.1251458 GABARAPL1 GABA(A) receptor-associated protein like 1
TC07000430.hg.1 -0.6957190 7.276184 -5.230374 0.0005586 0.0449316 0.1231875 POM121 POM121 transmembrane nucleoporin
TC08001736.hg.1 0.7828860 4.650255 5.230191 0.0005587 0.0449316 0.1229471 EPPK1 epiplakin 1
PSR12029411.hg.1 -0.5486775 10.747461 -5.230143 0.0005588 0.0449316 0.1228838 — —
PSR17013132.hg.1 -0.6452584 8.744392 -5.227088 0.0005610 0.0450621 0.1188703 — —
TC05000698.hg.1 0.7240770 5.994995 5.225153 0.0005625 0.0451187 0.1163275 FAM53C family with sequence similarity 53, member C
TC02002067.hg.1 -0.6844069 5.331310 -5.224419 0.0005630 0.0451187 0.1153623 KRCC1 lysine-rich coiled-coil 1
TC10000418.hg.1 1.0480675 7.037001 5.703193 0.0006551 0.0483513 0.1152532 HKDC1 hexokinase domain containing 1
TC14001022.hg.1 0.7113202 4.287802 5.222159 0.0005647 0.0451659 0.1123920 EGLN3 egl-9 family hypoxia-inducible factor 3
TC03003298.hg.1 -0.6679960 7.613215 -5.221913 0.0005649 0.0451659 0.1120683 TCTEX1D2 Tctex1 domain containing 2
3196675_st -0.5625276 10.252940 -5.220543 0.0005659 0.0451966 0.1102671 — —
TC21000302.hg.1 0.7039264 5.102519 5.219683 0.0005665 0.0451970 0.1091350 C21orf91 chromosome 21 open reading frame 91
TC6_apd_hap1000034.hg.1 0.6503457 7.862543 5.215706 0.0005695 0.0453330 0.1039040 MICB MHC class I polypeptide-related sequence B
TC16001494.hg.1 -0.5957840 9.234018 -5.214260 0.0005706 0.0453687 0.1020006 FUS FUS RNA binding protein
TC14000356.hg.1 0.7558878 7.423384 5.250175 0.0005803 0.0457248 0.0989044 DAAM1 dishevelled associated activator of morphogenesis 1
TC18000149.hg.1 -0.6812962 6.623720 -5.210755 0.0005733 0.0455286 0.0973864 MOCOS molybdenum cofactor sulfurase
PSR17013128.hg.1 -0.6448122 10.088452 -5.210939 0.0005743 0.0455615 0.0959945 — —
3475642_st 0.5638925 10.256285 5.208420 0.0005751 0.0455670 0.0943117 — —
TC0X001223.hg.1 0.6881298 8.757763 5.205551 0.0005772 0.0456894 0.0905319 RNU6-30P RNA, U6 small nuclear 30, pseudogene
3670250_st -0.5824898 10.591247 -5.204082 0.0005784 0.0457101 0.0885961 — —
47424037_st -0.6313303 1.833969 -5.203517 0.0005788 0.0457101 0.0878521 — —
TC15002424.hg.1 0.7562749 5.817208 5.203613 0.0005799 0.0457248 0.0863483 NBEAP1 neurobeachin pseudogene 1
TC03001845.hg.1 -0.6247726 8.924756 -5.194140 0.0005861 0.0460589 0.0754876 HMGN2P25 high mobility group nucleosomal binding domain 2 pseudogene 25
TC06001325.hg.1 -0.7345856 6.502434 -5.193581 0.0005865 0.0460589 0.0747498 GPLD1 glycosylphosphatidylinositol specific phospholipase D1
TC15001553.hg.1 -0.9102281 6.484260 -5.444739 0.0006406 0.0479566 0.0725479 RBPMS2 RNA binding protein with multiple splicing 2
TC02001372.hg.1 0.6344487 1.919016 5.191521 0.0005881 0.0461336 0.0720320 FBXO36-IT1 FBXO36 intronic transcript 1 (non-protein coding)
TC03002693.hg.1 -0.6865123 8.777954 -5.187715 0.0005911 0.0463159 0.0670080 EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
TC03000822.hg.1 0.8348531 3.881000 5.259933 0.0006086 0.0470585 0.0644424 MED12L mediator complex subunit 12-like
TC11002370.hg.1 0.7097490 5.029623 5.182326 0.0005953 0.0464937 0.0598908 USP2 ubiquitin specific peptidase 2
TC15001107.hg.1 -0.6616513 5.765161 -5.180753 0.0005966 0.0465396 0.0578115 FAM189A1 family with sequence similarity 189, member A1
TC04001578.hg.1 -0.7563284 9.049697 -5.292997 0.0006236 0.0475066 0.0543613 PPP1R14BP3 protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 3
47419845_st 0.5680333 1.600919 5.173134 0.0006026 0.0469013 0.0477397 — —
TC10000374.hg.1 -0.5536352 1.603920 -5.172441 0.0006032 0.0469013 0.0468223 LINC00845 long intergenic non-protein coding RNA 845
TC14000585.hg.1 0.6352638 2.559513 5.170954 0.0006044 0.0469424 0.0448548 PPP4R4 protein phosphatase 4, regulatory subunit 4
TC14001693.hg.1 0.6151426 9.013685 5.167669 0.0006070 0.0470585 0.0405080 LGALS3 lectin, galactoside-binding, soluble, 3
TC11000910.hg.1 0.6537938 7.615912 5.166638 0.0006079 0.0470585 0.0391434 SCARNA9 small Cajal body-specific RNA 9
TC17001542.hg.1 -0.6338382 8.840155 -5.166227 0.0006082 0.0470585 0.0385996 HMGN2P15 high mobility group nucleosomal binding domain 2 pseudogene 15
TC16000269.hg.1 0.7342975 3.621872 5.162335 0.0006114 0.0472241 0.0334466 — —
TC03003038.hg.1 -0.6497215 6.765180 -5.158968 0.0006141 0.0472346 0.0289870 ZBTB20 zinc finger and BTB domain containing 20
TC18000282.hg.1 -0.6531185 6.405964 -5.158932 0.0006141 0.0472346 0.0289396 METTL4 methyltransferase like 4
TC06001260.hg.1 -0.6450758 6.575543 -5.158887 0.0006142 0.0472346 0.0288790 TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TC6_mann_hap4000173.hg.1 -0.7071006 6.922520 -5.155798 0.0006167 0.0473778 0.0247853 VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
TC15002568.hg.1 0.7346602 4.472006 5.154059 0.0006181 0.0473860 0.0224805 — —
TC01005437.hg.1 -0.6837151 6.051114 -5.154036 0.0006182 0.0473860 0.0224499 SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
TC17000821.hg.1 0.7352864 5.481838 5.151315 0.0006204 0.0475066 0.0188429 SSTR2 somatostatin receptor 2
TC04001201.hg.1 0.8165378 5.987945 5.257811 0.0006450 0.0480305 0.0185394 CHIC2 cysteine-rich hydrophobic domain 2
TC19001583.hg.1 0.6935413 4.731917 5.149434 0.0006220 0.0475066 0.0163482 LOC284344 uncharacterized LOC284344
TC6_cox_hap2000145.hg.1 -0.6193342 2.453333 -5.148188 0.0006230 0.0475066 0.0146944 XXbac-BPG27H4.8 novel transcript
TC06002224.hg.1 0.6860443 4.830861 5.147324 0.0006237 0.0475066 0.0135482 ULBP3 UL16 binding protein 3
TC12002267.hg.1 -0.7219289 3.567305 -5.147107 0.0006239 0.0475066 0.0132614 — —
TC07001245.hg.1 0.6916772 6.685575 5.146448 0.0006245 0.0475066 0.0123859 FKBP14 FK506 binding protein 14, 22 kDa
TC05002014.hg.1 0.6909968 4.264729 5.144706 0.0006259 0.0475522 0.0100750 GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
TC6_dbb_hap3000053.hg.1 0.6444953 7.847643 5.143342 0.0006271 0.0475522 0.0082638 MICB MHC class I polypeptide-related sequence B
TC6_dbb_hap3000062.hg.1 0.6453122 6.415960 5.142501 0.0006278 0.0475522 0.0071486 SNORA38 small nucleolar RNA, H/ACA box 38
TC6_mcf_hap5000057.hg.1 0.6453122 6.415960 5.142501 0.0006278 0.0475522 0.0071486 SNORA38 small nucleolar RNA, H/ACA box 38
TC11000146.hg.1 0.5462824 1.630041 5.141317 0.0006287 0.0475764 0.0055755 — —
TC15001877.hg.1 -0.7009467 4.479048 -5.138322 0.0006313 0.0476919 0.0015992 — —
PSR14007791.hg.1 -0.6402663 6.935289 -5.137896 0.0006316 0.0476919 0.0010328 — —
PSR17008084.hg.1 -0.8598424 6.913900 -5.321518 0.0006766 0.0489493 -0.0016755 — —
TC18000535.hg.1 0.6272938 7.849934 5.130640 0.0006378 0.0479566 -0.0086086 RNU6-737P RNA, U6 small nuclear 737, pseudogene
TC06001454.hg.1 0.6632139 5.733151 5.129162 0.0006390 0.0479566 -0.0105735 — —
TC04001565.hg.1 0.7435475 3.430401 5.128726 0.0006394 0.0479566 -0.0111536 PCDH18 protocadherin 18
TC11002177.hg.1 0.6453394 9.867409 5.134825 0.0006409 0.0479566 -0.0112409 RNU6-16P RNA, U6 small nuclear 16, pseudogene
TC0X002222.hg.1 0.7712667 2.517970 5.230195 0.0006647 0.0485247 -0.0124689 TENM1 teneurin transmembrane protein 1
TC15001907.hg.1 0.6266444 2.225332 5.126439 0.0006414 0.0479566 -0.0141945 — —
3670244_st -0.6113646 8.653613 -5.126430 0.0006414 0.0479566 -0.0142067 — —
TC0X001230.hg.1 0.7554295 3.962339 5.125457 0.0006422 0.0479566 -0.0155016 TMSB15A thymosin beta 15a
TC04001465.hg.1 0.6506668 6.514989 5.124993 0.0006426 0.0479566 -0.0161190 PLA2G12A phospholipase A2, group XIIA
TC15000070.hg.1 0.6896810 4.321921 5.122784 0.0006445 0.0480305 -0.0190574 SNORD116-27 small nucleolar RNA, C/D box 116-27
TC10002327.hg.1 0.6849932 5.401344 5.119287 0.0006475 0.0481711 -0.0237111 — —
TC02000116.hg.1 0.7171633 5.826736 5.117511 0.0006491 0.0482349 -0.0260765 RHOB ras homolog family member B
TC15001571.hg.1 0.8506532 5.738701 5.253610 0.0006837 0.0492002 -0.0280209 DENND4A DENN/MADD domain containing 4A
TC08002607.hg.1 0.7763028 4.896833 5.125017 0.0006528 0.0483258 -0.0283677 SGK3 serum/glucocorticoid regulated kinase family, member 3
TC11001451.hg.1 0.6530688 8.752407 5.114595 0.0006516 0.0483258 -0.0299595 — —
TC16001143.hg.1 0.7206189 7.969936 5.128071 0.0006549 0.0483513 -0.0299704 RNU6-20P RNA, U6 small nuclear 20, pseudogene
TC03002165.hg.1 0.6334740 7.182044 5.113212 0.0006528 0.0483258 -0.0318018 CEP19 centrosomal protein 19kDa
TC11002237.hg.1 0.6400483 2.278797 5.112963 0.0006530 0.0483258 -0.0321328 MMP12 matrix metallopeptidase 12 (macrophage elastase)
TC17002724.hg.1 -0.5923782 9.739159 -5.108939 0.0006566 0.0483513 -0.0374950 SRSF1 serine/arginine-rich splicing factor 1
TC05000855.hg.1 -0.6728632 8.555496 -5.107829 0.0006575 0.0483513 -0.0389751 LARP1 La ribonucleoprotein domain family, member 1
TC07000467.hg.1 -0.6540509 7.121709 -5.106925 0.0006583 0.0483513 -0.0401801 WBSCR16 Williams-Beuren syndrome chromosome region 16
TC12001439.hg.1 0.6764317 4.984266 5.105951 0.0006592 0.0483513 -0.0414785 VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
TC21001012.hg.1 -0.7110689 4.500177 -5.105550 0.0006596 0.0483513 -0.0420136 — —
TC10000702.hg.1 -0.7215925 5.516363 -5.105431 0.0006597 0.0483513 -0.0421712 MARVELD1 MARVEL domain containing 1
TC12000049.hg.1 -0.7205812 3.945164 -5.105002 0.0006600 0.0483513 -0.0427434 — —
PSR17014494.hg.1 -0.6926177 7.124228 -5.104777 0.0006602 0.0483513 -0.0430433 — —
TC01003229.hg.1 0.6576515 5.522222 5.099995 0.0006645 0.0485247 -0.0494220 TDRKH tudor and KH domain containing
TC15001370.hg.1 -0.5757439 1.455523 -5.099786 0.0006647 0.0485247 -0.0497013 — —
PSR17013130.hg.1 -0.6338747 9.176639 -5.096950 0.0006672 0.0486593 -0.0534865 — —
TC01005527.hg.1 0.6471076 2.963555 5.095895 0.0006682 0.0486779 -0.0548943 — —
TC15000223.hg.1 -0.6297671 7.733676 -5.091615 0.0006720 0.0489077 -0.0606097 ARHGAP11A Rho GTPase activating protein 11A
TC0X001453.hg.1 -0.6131689 1.723375 -5.090260 0.0006732 0.0489462 -0.0624193 MIR892A microRNA 892a
TC09000037.hg.1 0.6792739 6.524201 5.089266 0.0006741 0.0489493 -0.0637465 CD274 CD274 molecule
TC07001091.hg.1 -0.6881723 4.997400 -5.087333 0.0006759 0.0489493 -0.0663296 ELFN1-AS1 ELFN1 antisense RNA 1
TC22000624.hg.1 -0.6454155 5.958491 -5.087303 0.0006759 0.0489493 -0.0663692 TTC28 tetratricopeptide repeat domain 28
TC03002111.hg.1 0.5619362 1.951381 5.085624 0.0006774 0.0489493 -0.0686128 GMNC geminin coiled-coil domain containing
TC02000978.hg.1 0.6771128 4.895244 5.085620 0.0006774 0.0489493 -0.0686190 GCA grancalcin, EF-hand calcium binding protein
TC01006233.hg.1 0.6548643 6.762195 5.083814 0.0006791 0.0490180 -0.0710327 CHML choroideremia-like (Rab escort protein 2)
TC12001103.hg.1 -0.7396541 6.061012 -5.091531 0.0006827 0.0491772 -0.0728445 — —
TC19002498.hg.1 -0.6541274 5.696695 -5.080457 0.0006821 0.0491772 -0.0755208 — —
TC02002891.hg.1 0.7678438 6.124086 5.133089 0.0006970 0.0496668 -0.0768200 ARL4C ADP-ribosylation factor-like 4C
TC18000608.hg.1 0.6760245 5.938170 5.076084 0.0006862 0.0493068 -0.0813716 — —
TC07002048.hg.1 -0.6469662 5.816250 -5.075493 0.0006867 0.0493068 -0.0821614 AC073236.3 novel transcript
TC02002486.hg.1 0.7203731 4.204384 5.074887 0.0006873 0.0493068 -0.0829734 GRB14 growth factor receptor-bound protein 14
TC13000500.hg.1 0.6636844 5.789762 5.071481 0.0006904 0.0494526 -0.0875323 SHISA2 shisa family member 2
TC05003402.hg.1 0.6741180 4.059613 5.071180 0.0006907 0.0494526 -0.0879340 ZDHHC11B zinc finger, DHHC-type containing 11B
TC01005963.hg.1 0.6720276 7.405366 5.068338 0.0006934 0.0495917 -0.0917405 — —
TC08001074.hg.1 0.6700636 5.336592 5.067462 0.0006942 0.0495999 -0.0929141 SDAD1P1 SDA1 domain containing 1 pseudogene 1
TC14001706.hg.1 -0.6386725 7.210467 -5.066603 0.0006950 0.0496070 -0.0940642 AP5M1 adaptor-related protein complex 5, mu 1 subunit
TC18000094.hg.1 0.6888000 6.220613 5.063793 0.0006976 0.0496668 -0.0978293 GATA6 GATA binding protein 6
TC0X000520.hg.1 0.6475889 2.607930 5.063414 0.0006980 0.0496668 -0.0983364 TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
TC16000215.hg.1 0.6840004 7.103697 5.061976 0.0006993 0.0496668 -0.1002637 CCP110 centriolar coiled coil protein 110kDa
TC03002169.hg.1 0.5860867 8.986725 5.061958 0.0006993 0.0496668 -0.1002879 RNU6-42P RNA, U6 small nuclear 42, pseudogene
PSR17008081.hg.1 -0.6649450 5.908766 -5.057958 0.0007031 0.0498848 -0.1056498 — —
3615298_st -0.6808324 8.036502 -5.056689 0.0007043 0.0499199 -0.1073517 — —
47423090_st -0.5329187 1.325029 -5.055861 0.0007051 0.0499255 -0.1084631 — —

This table can be regarded as a final output of the pairwise differential expression pipeline.

9.split this into up- and down-regulated gene tables and lists for analysis and pathway mapping

up <- diff[diff$logFC > 0,]
write.csv(up,"pairwise_test_results/tGF.cGF/up.tGF.cGF",row.names = F,quote = F)
write.csv(up$name,"pairwise_test_results/tGF.cGF/up.tGF.cGF.gene.list",row.names = F,quote = F)
down <- diff[diff$logFC < 0,]
write.csv(down,"pairwise_test_results/tGF.cGF/down.tGF.cGF",row.names = F,quote = F)
write.csv(down$name,"pairwise_test_results/tGF.cGF/down.tGF.cGF.gene.list",row.names = F,quote = F)

10. Plotting intensity and variance, highlighting significant differences (plot shown at start of document also)

png("pairwise_test_results/tGF.cGF/tGF.cGF.MD.png")
plotMD(fit,status = results[,3], legend = F, hl.col = c("red","blue"), main = "tGF vs. cGF", xlim=c(0,14))
abline(0,0,col="red",lty=3)
dev.off()
## png 
##   2
plotMD(fit,status = results[,3], legend = F, hl.col = c("red","blue"), main = "tGF vs. cGF", xlim=c(0,14))
abline(0,0,col="red",lty=3)

We now have full tables for differentially expressed genes. We can also generate tables of up- and down-regulated pathways via the Reactome.db. These will be handled in a separate script.

11. Linking to GO enrichment analysis: step 1, gather a set of background genes to compare

This pipeline is adapted from https://bioconductor.org/packages/devel/workflows/vignettes/maEndToEnd/inst/doc/MA-Workflow.html (this required a good deal of modification to current pipeline)

First, we get a “control set” of genes, those which have similar expression levels but are not differentially expressed. this is handled by a package “genefilter”.

library(genefilter)
library(Biobase)
#make a list of diff genes
diff.probe <- subset(x = diff)$probe
background.genes <- genefilter::genefinder(eset, as.character(diff.probe), method = "manhattan", scale = "none")
background.genes <- sapply(background.genes, function(x) x$indices)
background.genes <- as.vector(background.genes)
back.genes <- featureNames(project.bgcorrect.norm.avg)[background.genes]

We now remove any differentially expressed genes from the background gene set and verify that it is correct: the diff set and the background set should have nothing in common.

back.genes <- setdiff(back.genes, diff.probe)
intersect(back.genes, diff.probe)
## character(0)

12. Examine mean intensity of the diff set, background set and all probes

library(cancerTiming)
multidensity(list(
    all = fit.tGF.cGF[,"AveExpr"],
    fore = diff[,"AveExpr"],  
    back = fit.tGF.cGF[rownames(fit.tGF.cGF) %in% back.genes, "AveExpr"]),
  col = c("#e46981", "#ae7ee2", "#a7ad4a"),
  xlab = "mean expression",
  main = "cGFR vs cGF: Differentially Expressed, Background, and All gene expression levels"
)

13. GO enrichment analysis

Is the differential expression set enriched in particular functional categories? This is why we have created a background gene set, so that we know the “typical” functional distribution of genes expressed at similar levels. We will connect the probe names to GO categories and run a few tests for pathway enrichment.

library(topGO)

gene.IDs <- rownames(eset)
in.universe <- gene.IDs %in% c(diff.probe,back.genes)
in.selection <- gene.IDs %in% diff.probe

all.genes <- in.selection[in.universe]
all.genes <- factor(as.integer(in.selection[in.universe]))
names(all.genes) <- gene.IDs[in.universe]

#this builds a database with all GO information related to our two test sets AND whether the gene is differentially expressed
top_GO_data <- new("topGOdata", ontology = "BP", allGenes = all.genes,
 nodeSize = 10, annot = annFUN.db, affyLib = "hta20transcriptcluster.db")

result_top_GO_elim <- 
  runTest(top_GO_data, algorithm = "elim", statistic = "Fisher")
result_top_GO_classic <- 
  runTest(top_GO_data, algorithm = "classic", statistic = "Fisher")
library(stringr)
res_top_GO <- GenTable(top_GO_data, Fisher.elim = result_top_GO_elim,
        Fisher.classic = result_top_GO_classic,
        orderBy = "Fisher.elim" , topNodes = 100)

genes_top_GO <- printGenes(top_GO_data, whichTerms = res_top_GO$GO.ID,
    chip = "hta20transcriptcluster.db", geneCutOff = 1000)

res_top_GO$sig_genes <- sapply(genes_top_GO, function(x){
                str_c(paste0(x[x$'raw p-value' == 2, "Symbol.id"],";"), 
                      collapse = "")
    })
kable(res_top_GO) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")
GO.ID Term Annotated Significant Expected Rank in Fisher.classic Fisher.elim Fisher.classic sig_genes
GO:0014066 regulation of phosphatidylinositol 3-kin… 22 15 5.77 1 4.1e-05 4.1e-05 PTPN13;PTPN13;PDGFC;BTN2A2;IER3;FYN;IL18;ERBB3;ERBB3;MIR21;IER3;IER3;IER3;IER3;IER3;
GO:0042271 susceptibility to natural killer cell me… 17 12 4.46 2 0.00015 0.00015 ULBP2;ULBP1;ULBP3;MICA;MICA;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0019835 cytolysis 16 11 4.19 4 0.00042 0.00042 GPLD1;MICA;MICA;MMD;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0001573 ganglioside metabolic process 10 8 2.62 6 0.00057 0.00057 NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
GO:0030101 natural killer cell activation 26 15 6.82 7 0.00062 0.00062 SLAMF7;ULBP2;ULBP1;ULBP3;MICA;MICA;TOX;IL18;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0051250 negative regulation of lymphocyte activa… 26 15 6.82 8 0.00062 0.00062 PELI1;BTN2A2;TNFAIP3;MICA;TNFAIP3;MICA;INHBA;PAG1;SFRP1;CD274;LGALS3;MIR21;MICA;MICA;MICA;
GO:0030330 DNA damage response, signal transduction… 32 17 8.39 11 0.00099 0.00099 SESN2;GADD45A;CCNB1;CCNB1;SOX4;MYO6;SOX4;MYO6;SNAI2;RPS6KA6;RPS6KA6;FOXM1;TFDP1;PMAIP1;PMAIP1;AURKA;AURKA;
GO:1901655 cellular response to ketone 13 9 3.41 15 0.00138 0.00138 ERRFI1;PTGER4;LARP1;AHR;FBXO32;SFRP1;FBXO32;DCPS;ATP2B1;
GO:0030278 regulation of ossification 25 14 6.55 16 0.00142 0.00142 SUCO;PTGER4;BMP6;ENPP1;TFAP2A;IL6;SNAI2;PTK2B;SFRP1;DKK1;MGP;MGP;MIR21;JAG1;
GO:0030149 sphingolipid catabolic process 11 8 2.88 17 0.00162 0.00162 NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
GO:0055067 monovalent inorganic cation homeostasis 23 13 6.03 21 0.00188 0.00188 NPPB;SLC9A2;SLC12A2;SLC12A2;SLC12A2;CA2;SPX;SLC4A8;EDNRB;EDNRB;SLC12A3;NEDD4L;ATP1A3;
GO:0050691 regulation of defense response to virus … 16 10 4.19 24 0.00234 0.00234 DTX3L;TNFAIP3;TNFAIP3;DDX58;IFIT1;MMP12;MICB;MICB;MICB;MICB;
GO:1901136 carbohydrate derivative catabolic proces… 26 14 6.82 25 0.00235 0.00235 PDE1A;HPSE;NT5E;NEU1;UPP1;MMP12;LUM;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
GO:0019233 sensory perception of pain 14 9 3.67 28 0.00298 0.00298 SCN9A;SCN9A;SCN9A;P2RY1;NPY1R;FYN;SPX;EDNRB;EDNRB;
GO:0050852 T cell receptor signaling pathway 19 11 4.98 29 0.00330 0.00330 NFKBIZ;BTN2A2;FYN;HLA-DQB1;RIPK2;PAG1;PAK3;PAK3;PTPRJ;PTPRJ;LGALS3;
GO:0062012 regulation of small molecule metabolic p… 52 23 13.63 30 0.00337 0.00337 SESN2;INSIG2;P2RY1;ZBTB20;CCNB1;HMGCS1;CCNB1;BMP6;ENPP1;GPLD1;PDP1;SNAI2;NCOA2;PTK2B;WDR5;ATP7A;IDI1;VDR;VDR;MIR21;PMAIP1;PMAIP1;SOGA1;
GO:0001933 negative regulation of protein phosphory… 76 31 19.92 31 0.00340 0.00340 CDKN2C;GADD45A;RGS4;ATF3;ERRFI1;JUN;CBLB;EIF4G1;PAQR3;CCNB1;DUSP1;CCNB1;BTN2A2;ENPP1;TNFAIP3;TNFAIP3;PRKAR2B;PKIA;PKIA;SFRP1;RPS6KA6;RPS6KA6;ZMYND11;DKK1;DUSP5;PTPRJ;PTPRJ;NA;FOXM1;PLK1;MIR21;
GO:0071456 cellular response to hypoxia 27 14 7.08 33 0.00373 0.00373 EPAS1;CCNA2;CCNB1;CCNB1;CITED2;STC1;SFRP1;ATP7A;EGLN3;CREBBP;MIR21;GATA6;PMAIP1;PMAIP1;
GO:0043086 negative regulation of catalytic activit… 118 44 30.93 37 0.00428 0.00428 CDKN2C;GADD45A;RGS4;ERRFI1;MAP2;DTX3L;SERPINI1;TIMP4;CBLB;PAQR3;DUSP1;BAG2;TNFAIP3;TNFAIP3;PRKAR2B;TFPI2;TFPI2;SH2D4A;PKIA;PKIA;SFRP1;ATP7A;ANOS1;RPS6KA3;IFIT1;DUSP5;PTPRJ;SERPINH1;BIRC3;SYTL2;PTPRJ;SYTL2;NA;CSRNP2;EDNRB;EDNRB;PPP4R4;LGALS3;THBS1;PLK1;MIR21;HMSD;PPP1R15A;SLPI;
GO:0044106 cellular amine metabolic process 10 7 2.62 39 0.00460 0.00460 SRM;NR4A2;SAT1;ATP7A;SAT1;GDPD1;MIR21;
GO:0043331 response to dsRNA 10 7 2.62 40 0.00460 0.00460 PELI1;RIPK2;DDX58;IFIT1;RIOK3;PMAIP1;PMAIP1;
GO:2000146 negative regulation of cell motility 45 20 11.80 43 0.00574 0.00574 NA;RHOB;TMEFF2;MITF;ROBO1;PTGER4;DUSP1;CITED2;STC1;TP53INP1;EPPK1;SFRP1;PTPRJ;PTPRJ;NAV3;THBS1;MIR21;JAG1;SEMG1;SEMG1;
GO:0046629 gamma-delta T cell activation 15 9 3.93 44 0.00575 0.00575 MICA;MICA;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0043967 histone H4 acetylation 15 9 3.93 45 0.00575 0.00575 JADE2;JADE2;TRRAP;WDR5;HCFC1;KAT6B;MSL1;USP22;SMARCB1;
GO:0035335 peptidyl-tyrosine dephosphorylation 13 8 3.41 50 0.00754 0.00754 NA;PTPN13;PTPN13;DUSP1;DUSP5;PTPRJ;PTPRJ;PTPN9;
GO:0009311 oligosaccharide metabolic process 13 8 3.41 51 0.00754 0.00754 NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
GO:0072422 signal transduction involved in DNA dama… 18 10 4.72 52 0.00755 0.00755 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;PLK1;MIR21;AURKA;AURKA;
GO:0097306 cellular response to alcohol 18 10 4.72 53 0.00755 0.00755 PTGER4;LARP1;HMGCS1;GPLD1;AHR;LANCL2;INHBA;TP53INP1;SFRP1;ATP2B1;
GO:0051216 cartilage development 32 15 8.39 57 0.00902 0.00902 TGFBR2;IFT80;BMP6;GPLD1;CTGF;COL14A1;STC1;SNAI2;NFIB;ATP7A;SERPINH1;MGP;LUM;MGP;MIR21;
GO:0016052 carbohydrate catabolic process 21 11 5.50 61 0.00908 0.00908 ZBTB20;NEU1;HKDC1;PGM2L1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;NEU1;
GO:0048705 skeletal system morphogenesis 35 16 9.17 62 0.00947 0.00947 INSIG2;TGFBR2;IFT80;SH3PXD2B;BMP6;TFAP2A;CTGF;COL14A1;STC1;SFRP1;MED12;ARID5B;ARID5B;SERPINH1;MGP;MGP;
GO:0046850 regulation of bone remodeling 11 7 2.88 64 0.00981 0.00981 SUCO;TNFAIP3;TNFAIP3;IL6;CA2;SFRP1;ITGB3;
GO:0030104 water homeostasis 11 7 2.88 65 0.00981 0.00981 FLG;FLG;FLG;FLG;CLDN1;PRKAR2B;NEDD4L;
GO:0042493 response to drug 156 54 40.89 67 0.00982 0.00982 SYT11;RGS4;ERRFI1;RAB3B;JUN;SLC19A2;MTR;SLC6A9;DAB1;RHOB;NR4A2;TGFBR2;P2RY1;TIMP4;CLDN1;ABCG2;CCNA2;ABCG2;CCNB1;LARP1;HMGCS1;DUSP1;CCNB1;MYO6;TNFAIP3;GPLD1;FYN;MYO6;TNFAIP3;AHR;IL6;PRKAR2B;ZNF277;INHBA;POLB;CA2;RIPK2;NCOA2;TP53INP1;FBXO32;SLC7A2;PTK2B;SFRP1;FBXO32;ACER2;DCPS;EPS8;SLC25A30;THBS1;COQ7;MIR21;GATA6;JUNB;JAG1;
GO:0001101 response to acid chemical 59 24 15.47 69 0.00992 0.00992 SESN2;INSIG2;CLDN1;PDGFC;PTGER4;CCNB1;DUSP1;CCNB1;BMP6;FYN;CTGF;LANCL2;PTK2B;SFRP1;GLDC;ACER2;ATP7A;DKK1;SESN3;SESN3;MICB;MICB;MICB;MICB;
GO:0072413 signal transduction involved in mitotic … 16 9 4.19 70 0.01013 0.01013 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;MIR21;AURKA;AURKA;
GO:1902402 signal transduction involved in mitotic … 16 9 4.19 71 0.01013 0.01013 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;MIR21;AURKA;AURKA;
GO:1902403 signal transduction involved in mitotic … 16 9 4.19 72 0.01013 0.01013 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;MIR21;AURKA;AURKA;
GO:0062013 positive regulation of small molecule me… 16 9 4.19 73 0.01013 0.01013 P2RY1;ZBTB20;CCNB1;CCNB1;BMP6;GPLD1;WDR5;PMAIP1;PMAIP1;
GO:0007409 axonogenesis 50 21 13.11 75 0.01022 0.01022 DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;EPHA7;FYN;NFIB;PAK3;ANOS1;PAK3;GFRA1;GFRA1;CDH4;FLRT3;
GO:0021953 central nervous system neuron differenti… 24 12 6.29 76 0.01033 0.01033 MAP2;NR4A2;ROBO1;SOX4;SOX4;INHBA;SFRP1;NFIB;AGTPBP1;ATP7A;DKK1;C21orf91;
GO:0090066 regulation of anatomical structure size 75 29 19.66 78 0.01096 0.01096 NPPB;RAB3B;PLEKHH2;MAP2;FN1;PLS1;P2RY1;SLC12A2;SLC12A2;SLC12A2;ITGA1;EPHA7;DOCK4;PTK2B;ATP7A;PAK3;TMSB15A;PAK3;TENM1;EPS8;EDNRB;EDNRB;TMOD2;TMOD2;SLC12A3;SCPEP1;MIR21;PPP1R15A;CDH4;
GO:0052547 regulation of peptidase activity 66 26 17.30 80 0.01197 0.01197 FN1;SERPINI1;TIMP4;ROBO1;EPHA7;FYN;CTGF;TFPI2;TFPI2;RIPK2;ANP32B;ACER2;ANOS1;RPS6KA3;FAS;SERPINH1;BIRC3;EGLN3;THBS1;MIR21;PMAIP1;PMAIP1;HMSD;SLPI;SEMG1;SEMG1;
GO:0043491 protein kinase B signaling 33 15 8.65 81 0.01263 0.01263 SESN2;PIK3R3;HPSE;HBEGF;BTN2A2;FYN;PTPRJ;SESN3;IL18;PTPRJ;SESN3;ERBB3;ERBB3;THBS1;MIR21;
GO:0043409 negative regulation of MAPK cascade 33 15 8.65 82 0.01263 0.01263 RGS4;ATF3;ERRFI1;PAQR3;DUSP1;BTN2A2;SFRP1;RPS6KA6;RPS6KA6;ZMYND11;DUSP5;PTPRJ;PTPRJ;FOXM1;MIR21;
GO:0014070 response to organic cyclic compound 159 58 41.68 22 0.01294 0.00196 RGS4;ERRFI1;JUN;ACSL3;PELI1;NR4A2;TGFBR2;P2RY1;CLDN1;CLOCK;CCNA2;CCNB1;LARP1;HMGCS1;GABRB2;DUSP1;CCNB1;BMP6;GPLD1;CTGF;AHR;IL6;PRKAR2B;INHBA;CA2;RIPK2;STC1;SNAI2;NCOA2;FBXO32;PTK2B;SFRP1;FBXO32;GLDC;DDX58;PAK3;HCFC1;MED12;PAK3;IFIT1;IL18;VDR;GRIP1;ATP2B1;LUM;VDR;CALCOCO1;GRIP1;EDNRB;EDNRB;THBS1;MIR21;SSTR2;RIOK3;PMAIP1;PMAIP1;JUNB;ATP1A3;
GO:2001020 regulation of response to DNA damage sti… 39 17 10.22 88 0.01326 0.01326 DTX3L;SKIL;IER3;TEX15;SNAI2;RADX;FANCB;RADX;FOXM1;MIR21;PMAIP1;PMAIP1;IER3;IER3;IER3;IER3;IER3;
GO:0007050 cell cycle arrest 48 20 12.58 90 0.01335 0.01335 CDKN2C;GADD45A;MLF1;SKIL;CCNB1;DUSP1;CCNB1;SOX4;SOX4;CUL1;INHBA;TP53INP1;FOXM1;TFDP1;THBS1;EVI2B;GATA6;PPP1R15A;AURKA;AURKA;
GO:0030336 negative regulation of cell migration 42 18 11.01 92 0.01339 0.01339 NA;RHOB;TMEFF2;MITF;ROBO1;PTGER4;DUSP1;CITED2;STC1;TP53INP1;EPPK1;SFRP1;PTPRJ;PTPRJ;NAV3;THBS1;MIR21;JAG1;
GO:0032091 negative regulation of protein binding 14 8 3.67 94 0.01360 0.01360 MAP2;BAG2;DKK1;IFIT2;IFIT1;SLPI;AURKA;AURKA;
GO:0033993 response to lipid 172 58 45.09 96 0.01381 0.01381 ERRFI1;JUN;INSIG2;PELI1;NR4A2;TGFBR2;TIMP4;CLDN1;CLOCK;CCNA2;PTGER4;CCNB1;HMGCS1;DUSP1;CCNB1;BMP6;TNFAIP3;GPLD1;CTGF;TNFAIP3;AHR;IL6;LANCL2;INHBA;CA2;RIPK2;STC1;SNAI2;NCOA2;FBXO32;PTK2B;SFRP1;FBXO32;CD274;GLDC;ACER2;RPS6KA3;MED12;DKK1;IL18;VDR;GRIP1;ATP2B1;VDR;CALCOCO1;GRIP1;EDNRB;EDNRB;THBS1;MIR21;SSTR2;JUNB;ATP1A3;SLPI;MICB;MICB;MICB;MICB;
GO:0050770 regulation of axonogenesis 22 11 5.77 97 0.01395 0.01395 DAB1;MAP2;FN1;CHN1;ROBO1;SKIL;ZSWIM6;EPHA7;PAK3;PAK3;CDH4;
GO:0007169 transmembrane receptor protein tyrosine … 112 40 29.36 98 0.01440 0.01440 ERRFI1;PIK3R3;NUCKS1;GRB14;CHN1;ROBO1;CBLB;PDGFC;HBEGF;ITGA1;ENPP1;GPLD1;EPHA7;FYN;CTGF;PTK2B;REPS2;PAK3;ANOS1;PAK3;ARID5B;MYOF;GFRA1;ARID5B;GFRA1;PTPRJ;SESN3;PTPRJ;SESN3;NA;EPS8;ERBB3;ERBB3;SHISA2;THBS1;MIR21;ITGB3;FLRT3;SOGA1;NCOA5;
GO:0050707 regulation of cytokine secretion 25 12 6.55 100 0.01524 0.01524 SYT11;IL1A;FN1;IL1RAP;PTGER4;BTN2A2;TNFAIP3;TNFAIP3;RIPK2;CD274;DDX58;MMP12;
GO:0052548 regulation of endopeptidase activity 64 25 16.78 103 0.01530 0.01530 SERPINI1;TIMP4;ROBO1;EPHA7;FYN;CTGF;TFPI2;TFPI2;RIPK2;ANP32B;ACER2;ANOS1;RPS6KA3;FAS;SERPINH1;BIRC3;EGLN3;THBS1;MIR21;PMAIP1;PMAIP1;HMSD;SLPI;SEMG1;SEMG1;
GO:0061564 axon development 61 24 15.99 105 0.01574 0.01574 JUN;TSPAN2;MTR;DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;EPHA7;FYN;NFIB;PAK3;ANOS1;PAK3;GFRA1;GFRA1;CDH4;FLRT3;
GO:0048812 neuron projection morphogenesis 80 30 20.97 106 0.01574 0.01574 NA;DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;ITGA1;EPHA7;FYN;CUX1;NFIB;ATP7A;PAK3;ANOS1;PAK3;GFRA1;GFRA1;GRIP1;GRIP1;NEDD4L;CDH4;FLRT3;AURKA;AURKA;
GO:0030154 cell differentiation 554 165 145.22 107 0.01583 0.01583 CDKN2C;NA;RGS4;SUCO;ATF3;ERRFI1;JUN;TTLL7;TSPAN2;WARS2;TDRKH;FLG;CR2;MTR;DAB1;TTLL7;FLG;FLG;FLG;RHOB;FOSL2;EPAS1;B3GNT2;KIF5C;MAP2;IL1A;NR4A2;FN1;CHN1;TGFBR2;MITF;ARL6;ALCAM;P2RY1;MLF1;SERPINI1;ROBO1;USF3;CLDN1;SKIL;EIF4G1;NFKBIZ;IFT80;TENM3;CLOCK;PAQR3;BBS7;TENM3;PTGER4;ZSWIM6;CCNB1;SLCO4C1;GABRB2;SH3PXD2B;CCNB1;ITGA1;FOXF2;BMP6;SOX4;BTN2A2;L3MBTL3;ENPP1;TFAP2A;GPLD1;KIAA0319;EPHA7;FYN;CTGF;CITED2;SOX4;IL6;PEG10;PUS7;CUX1;INHBA;CCDC71L;CA2;RIPK2;COL14A1;ZHX2;STC1;TEX15;SNAI2;TOX;MYBL1;TP53INP1;LRP12;PTK2B;SFRP1;PLAG1;MYBL1;ANP32B;WDR5;NFIB;AGTPBP1;S1PR3;ATP7A;PAK3;ANOS1;RPS6KA3;RBMX;MED12;PAK3;TENM1;RBMX;DKK1;ARID5B;KLF6;MYOF;GFRA1;ADAM12;ARID5B;GFRA1;PTPRJ;SERPINH1;EXPH5;IL18;PTPRJ;EXPH5;NAV3;SLC2A14;MGP;BHLHE41;VDR;GRIP1;CSRP2;BTG1;ERBB3;MGP;VDR;GRIP1;ERBB3;EDNRB;EDNRB;ARID4A;STON2;LGALS3;ARID4A;THBS1;TMOD2;RBPMS2;PTPN9;TMOD2;CREBBP;SLFN5;MIR21;EVI2B;MMD;UNK;SRSF1;ITGB3;GATA6;NEDD4L;JUNB;CDH4;JAG1;FLRT3;AURKA;SEMG1;AURKA;SEMG1;RBM11;C21orf91;SMARCB1;VPS52;
GO:0098742 cell-cell adhesion via plasma-membrane a… 31 14 8.13 108 0.01686 0.01686 DAB1;TGFBR2;ALCAM;IL1RAP;ROBO1;CLDN1;TENM3;PCDH18;TENM3;CDH10;TENM1;PCDH17;CDH4;FLRT3;
GO:0032535 regulation of cellular component size 52 21 13.63 111 0.01689 0.01689 RAB3B;PLEKHH2;MAP2;FN1;PLS1;SLC12A2;SLC12A2;SLC12A2;EPHA7;PTK2B;ATP7A;PAK3;TMSB15A;PAK3;TENM1;EPS8;TMOD2;TMOD2;SLC12A3;PPP1R15A;CDH4;
GO:0097485 neuron projection guidance 34 15 8.91 113 0.01729 0.01729 DAB1;B3GNT2;KIF5C;CHN1;ALCAM;ROBO1;ZSWIM6;EPHA7;FYN;NFIB;ANOS1;GFRA1;GFRA1;CDH4;FLRT3;
GO:0007411 axon guidance 34 15 8.91 114 0.01729 0.01729 DAB1;B3GNT2;KIF5C;CHN1;ALCAM;ROBO1;ZSWIM6;EPHA7;FYN;NFIB;ANOS1;GFRA1;GFRA1;CDH4;FLRT3;
GO:0110053 regulation of actin filament organizatio… 37 16 9.70 116 0.01752 0.01752 RGS4;PLEKHH2;TMEFF2;PTGER4;SH3PXD2B;CTGF;PTK2B;SFRP1;PAK3;TMSB15A;PAK3;TENM1;EPS8;TMOD2;TMOD2;MIR21;
GO:0043588 skin development 37 16 9.70 117 0.01752 0.01752 ERRFI1;FLG;FLG;FLG;FLG;FOSL2;CLDN1;HPSE;INHBA;ATP7A;DKK1;EXPH5;EXPH5;VDR;VDR;JAG1;
GO:0051048 negative regulation of secretion 37 16 9.70 118 0.01752 0.01752 SYT11;SLC30A1;FN1;P2RY1;PTGER4;BTN2A2;TNFAIP3;TNFAIP3;INHBA;RAB11FIP1;RAB11FIP1;SFRP1;SPX;ERBB3;ERBB3;TRIM9;
GO:0001818 negative regulation of cytokine producti… 37 16 9.70 119 0.01752 0.01752 SYT11;ERRFI1;NMI;FN1;PTGER4;BTN2A2;TNFAIP3;TNFAIP3;IL6;INHBA;CD274;DDX58;NAV3;THBS1;MIR21;GATA6;
GO:0031348 negative regulation of defense response 43 18 11.27 120 0.01756 0.01756 NMI;PTGER4;NT5E;TNFAIP3;MICA;TNFAIP3;MICA;IFIT1;MMP12;MIR21;RIOK3;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0051051 negative regulation of transport 84 31 22.02 121 0.01819 0.01819 CTTNBP2NL;SYT11;RGS4;SLC30A1;FN1;P2RY1;PTGER4;BTN2A2;TMEM14A;ENPP1;TNFAIP3;TNFAIP3;INHBA;PKIA;STC1;RAB11FIP1;PTK2B;PKIA;RAB11FIP1;SFRP1;ATP7A;SPX;ERBB3;ERBB3;TRIM9;LGALS3;THBS1;ITGB3;NEDD4L;SEMG1;SEMG1;
GO:0031670 cellular response to nutrient 12 7 3.15 122 0.01829 0.01829 P2RY1;FYN;SNAI2;SFRP1;VDR;ATP2B1;VDR;
GO:0032623 interleukin-2 production 12 7 3.15 123 0.01829 0.01829 IL1A;IL1RAP;TNFAIP3;TNFAIP3;RIPK2;IL18;NAV3;
GO:0007422 peripheral nervous system development 12 7 3.15 124 0.01829 0.01829 SERPINI1;CLDN1;MED12;ERBB3;ERBB3;EDNRB;EDNRB;
GO:0007167 enzyme linked receptor protein signaling… 164 55 42.99 125 0.01834 0.01834 ERRFI1;NPPB;PIK3R3;JUN;NUCKS1;TGFBRAP1;GRB14;CHN1;TGFBR2;ROBO1;CBLB;SKIL;PDGFC;LIFR;HBEGF;ITGA1;BMP6;ENPP1;GPLD1;EPHA7;FYN;CTGF;CITED2;PEG10;INHBA;PTK2B;RBPMS;SFRP1;REPS2;PAK3;ANOS1;PAK3;DKK1;ARID5B;MYOF;GFRA1;ARID5B;GFRA1;PTPRJ;SESN3;PTPRJ;SESN3;NA;EPS8;ERBB3;ERBB3;SHISA2;THBS1;RBPMS2;CREBBP;MIR21;ITGB3;FLRT3;SOGA1;NCOA5;
GO:1902041 regulation of extrinsic apoptotic signal… 20 10 5.24 126 0.01890 0.01890 ATF3;SKIL;TNFAIP3;TNFAIP3;SFRP1;FAS;LGALS3;THBS1;PMAIP1;PMAIP1;
GO:0071804 cellular potassium ion transport 20 10 5.24 127 0.01890 0.01890 RGS4;SLC9A2;SLC12A2;SLC12A2;SLC12A2;KCNV1;SLC12A3;MIR21;NEDD4L;ATP1A3;
GO:0071805 potassium ion transmembrane transport 20 10 5.24 128 0.01890 0.01890 RGS4;SLC9A2;SLC12A2;SLC12A2;SLC12A2;KCNV1;SLC12A3;MIR21;NEDD4L;ATP1A3;
GO:0032990 cell part morphogenesis 81 30 21.23 129 0.01897 0.01897 NA;DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;ITGA1;EPHA7;FYN;CUX1;NFIB;ATP7A;PAK3;ANOS1;PAK3;GFRA1;GFRA1;GRIP1;GRIP1;NEDD4L;CDH4;FLRT3;AURKA;AURKA;
GO:0120039 plasma membrane bounded cell projection … 81 30 21.23 130 0.01897 0.01897 NA;DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;ITGA1;EPHA7;FYN;CUX1;NFIB;ATP7A;PAK3;ANOS1;PAK3;GFRA1;GFRA1;GRIP1;GRIP1;NEDD4L;CDH4;FLRT3;AURKA;AURKA;
GO:0048858 cell projection morphogenesis 81 30 21.23 131 0.01897 0.01897 NA;DAB1;B3GNT2;KIF5C;MAP2;NR4A2;FN1;CHN1;ALCAM;ROBO1;SKIL;ZSWIM6;ITGA1;EPHA7;FYN;CUX1;NFIB;ATP7A;PAK3;ANOS1;PAK3;GFRA1;GFRA1;GRIP1;GRIP1;NEDD4L;CDH4;FLRT3;AURKA;AURKA;
GO:0006508 proteolysis 241 77 63.17 135 0.02047 0.02047 TINAGL1;CR2;PDCL3;PELI1;FBXO48;FN1;DTX3L;SERPINI1;TIMP4;ROBO1;USP53;TENM3;CLOCK;CCNA2;BBS7;TENM3;CCNB1;SGTB;CCNB1;SGTB;KDM1B;BAG2;TNFAIP3;GPLD1;EPHA7;FYN;CTGF;TNFAIP3;CPA4;CUL1;TFPI2;UBE2H;TFPI2;TRRAP;POLB;RIPK2;PTK2B;SFRP1;ANP32B;DDX58;AGTPBP1;ECPAS;ACER2;ATG4A;ANOS1;RPS6KA3;RBMX;HCFC1;RBMX;ADAM12;FAS;SERPINH1;BIRC3;MMP12;USP2;TMTC3;CPM;AMN1;EGLN3;TRIM9;THBS1;CCP110;PLK1;SCPEP1;MIR21;USP22;NEDD4L;PMAIP1;PMAIP1;HMSD;SLPI;AURKA;SEMG1;AURKA;SEMG1;ADAMTS1;ADAMTS1;
GO:0071156 regulation of cell cycle arrest 23 11 6.03 136 0.02057 0.02057 GADD45A;CCNB1;CCNB1;SOX4;SOX4;FOXM1;TFDP1;EVI2B;GATA6;AURKA;AURKA;
GO:0006813 potassium ion transport 23 11 6.03 137 0.02057 0.02057 RGS4;SLC9A2;SLC12A2;SLC12A2;SLC12A2;KCNV1;PTK2B;SLC12A3;MIR21;NEDD4L;ATP1A3;
GO:0048869 cellular developmental process 580 171 152.03 139 0.02120 0.02120 CDKN2C;NA;RGS4;SUCO;ATF3;ERRFI1;JUN;TTLL7;TSPAN2;WARS2;TDRKH;FLG;CR2;MTR;DAB1;TTLL7;FLG;FLG;FLG;RHOB;FOSL2;EPAS1;B3GNT2;KIF5C;MAP2;IL1A;RND3;NR4A2;FN1;CHN1;TGFBR2;MITF;ARL6;ALCAM;P2RY1;MLF1;SERPINI1;ROBO1;USF3;CLDN1;SKIL;EIF4G1;NFKBIZ;IFT80;TENM3;CLOCK;PAQR3;BBS7;TENM3;PTGER4;ZSWIM6;CCNB1;SLCO4C1;GABRB2;SH3PXD2B;CCNB1;ITGA1;FOXF2;BMP6;SOX4;BTN2A2;L3MBTL3;ENPP1;TFAP2A;GPLD1;KIAA0319;EPHA7;FYN;CTGF;CITED2;SOX4;IL6;PEG10;ZNF277;PUS7;CUX1;INHBA;CCDC71L;CA2;RIPK2;COL14A1;ZHX2;STC1;TEX15;SNAI2;TOX;MYBL1;TP53INP1;LRP12;PTK2B;SFRP1;PLAG1;MYBL1;ANP32B;WDR5;NFIB;AGTPBP1;S1PR3;RP2;ATP7A;PAK3;ANOS1;RPS6KA3;RBMX;MED12;PAK3;TENM1;RBMX;DKK1;ARID5B;KLF6;NA;MYOF;GFRA1;ADAM12;ARID5B;GFRA1;PTPRJ;SERPINH1;EXPH5;IL18;PTPRJ;EXPH5;NAV3;FOXM1;SLC2A14;MGP;EPS8;BHLHE41;VDR;GRIP1;CSRP2;BTG1;ERBB3;MGP;VDR;GRIP1;ERBB3;EDNRB;EDNRB;ARID4A;STON2;LGALS3;ARID4A;THBS1;TMOD2;RBPMS2;PTPN9;TMOD2;CREBBP;SLFN5;MIR21;EVI2B;MMD;UNK;SRSF1;ITGB3;GATA6;NEDD4L;JUNB;CDH4;JAG1;FLRT3;AURKA;SEMG1;AURKA;SEMG1;RBM11;C21orf91;SMARCB1;VPS52;
GO:0042330 taxis 85 31 22.28 140 0.02172 0.02172 DAB1;B3GNT2;KIF5C;CHN1;ALCAM;ROBO1;ZSWIM6;SLC12A2;HBEGF;DUSP1;SLC12A2;SLC12A2;ITGA1;EPHA7;FYN;IL6;DOCK4;PTK2B;NFIB;ANOS1;GFRA1;GFRA1;PTPRJ;PTPRJ;EDNRB;EDNRB;LGALS3;THBS1;ITGB3;CDH4;FLRT3;
GO:0006935 chemotaxis 85 31 22.28 141 0.02172 0.02172 DAB1;B3GNT2;KIF5C;CHN1;ALCAM;ROBO1;ZSWIM6;SLC12A2;HBEGF;DUSP1;SLC12A2;SLC12A2;ITGA1;EPHA7;FYN;IL6;DOCK4;PTK2B;NFIB;ANOS1;GFRA1;GFRA1;PTPRJ;PTPRJ;EDNRB;EDNRB;LGALS3;THBS1;ITGB3;CDH4;FLRT3;
GO:0051046 regulation of secretion 118 41 30.93 142 0.02174 0.02174 SYT11;NPPB;RAB3B;SLC30A1;ACSL3;IL1A;FN1;P2RY1;IL1RAP;CLOCK;PTGER4;BMP6;SOX4;BTN2A2;MYO6;TNFAIP3;GPLD1;SOX4;MYO6;TNFAIP3;IL6;INHBA;RIPK2;STC1;RAB11FIP1;RAB11FIP1;SFRP1;CD274;DDX58;SYTL2;MMP12;EXPH5;SYTL2;EXPH5;SPX;ERBB3;ERBB3;EDNRB;EDNRB;TRIM9;RAB8B;
GO:0043902 positive regulation of multi-organism pr… 29 13 7.60 145 0.02251 0.02251 JUN;NUCKS1;P2RY1;LARP1;BMP6;INHBA;RIPK2;IFIT1;EDNRB;EDNRB;AURKA;AURKA;SMARCB1;
GO:0010906 regulation of glucose metabolic process 15 8 3.93 149 0.02259 0.02259 SESN2;ENPP1;GPLD1;NCOA2;WDR5;PMAIP1;PMAIP1;SOGA1;
GO:0072431 signal transduction involved in mitotic … 15 8 3.93 150 0.02259 0.02259 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;AURKA;AURKA;
GO:0006977 DNA damage response, signal transduction… 15 8 3.93 151 0.02259 0.02259 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;AURKA;AURKA;
GO:1902400 intracellular signal transduction involv… 15 8 3.93 152 0.02259 0.02259 GADD45A;CCNB1;CCNB1;SOX4;SOX4;TFDP1;AURKA;AURKA;
GO:0033555 multicellular organismal response to str… 15 8 3.93 153 0.02259 0.02259 NR4A2;SCN9A;SCN9A;SCN9A;EIF4G1;EDNRB;EDNRB;THBS1;
GO:0043473 pigmentation 15 8 3.93 154 0.02259 0.02259 MITF;ARL6;BBS7;SNAI2;ATP7A;EDNRB;EDNRB;RAB11B;
GO:0009628 response to abiotic stimulus 181 65 47.44 19 0.02293 0.00167 GADD45A;ERRFI1;JUN;NUCKS1;RHOB;EPAS1;NABP1;IL1A;NR4A2;TGFBR2;TSC22D2;P2RY1;CLDN1;CDS1;USP53;CLOCK;CCNA2;PTGER4;CCNB1;SLC12A2;HMGCS1;DUSP1;CCNB1;SLC12A2;SLC12A2;BMP6;GMPR;SLC25A27;BAG2;GPLD1;ELOVL4;FYN;CTGF;CITED2;MICA;MICA;POLB;CA2;STC1;SNAI2;TP53INP1;PTK2B;SFRP1;ATP7A;MYOF;FAS;MMP12;USP2;ATP2B1;EGLN3;THBS1;CREBBP;MIR21;GATA6;PMAIP1;PMAIP1;JUNB;RAB11B;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0005996 monosaccharide metabolic process 32 14 8.39 156 0.02295 0.02295 SESN2;ATF3;NPY1R;ENPP1;GPLD1;NCOA2;WDR5;HKDC1;PGM2L1;SLC2A3;SLC2A3;PMAIP1;PMAIP1;SOGA1;
GO:0002456 T cell mediated immunity 35 15 9.17 157 0.02315 0.02315 ULBP2;ULBP1;ULBP3;MICA;MICA;IL6;IL18;JAG1;MICB;MICA;MICB;MICA;MICB;MICA;MICB;
GO:0042127 regulation of cell proliferation 281 88 73.66 158 0.02324 0.02324 CDKN2C;ATF3;TNFRSF9;ERRFI1;JUN;FOSL2;PDCL3;PELI1;IL1A;FN1;PDE1A;TGFBR2;MITF;EAF2;ROBO1;P3H2;EIF4G1;IFT80;HPSE;CCNA2;PDGFC;CCNB1;LIFR;HBEGF;DUSP1;CCNB1;ITGA1;BMP6;SOX4;BTN2A2;SLC25A27;TNFAIP3;TFAP2A;GPLD1;CTGF;SOX4;TNFAIP3;AHR;IL6;TES;CUL1;CDCA7L;TNS3;INHBA;RIPK2;SNAI2;TP53INP1;EPPK1;PTK2B;SFRP1;PLAG1;SGK3;CD274;NFIB;ACER2;S1PR3;SAT1;ATP7A;SAT1;TENM1;PTPRJ;MMP12;IL18;PTPRJ;FOXM1;STYK1;VDR;BTG1;ERBB3;VDR;ERBB3;EDNRB;TFDP1;EDNRB;EGLN3;LGALS3;THBS1;CCNB2;RBPMS2;MIR21;SSTR2;ITGB3;GATA6;C18orf54;JAG1;ADAMTS1;ADAMTS1;SMARCB1;
GO:0014068 positive regulation of phosphatidylinosi… 10 6 2.62 162 0.02460 0.02460 PDGFC;FYN;IL18;ERBB3;ERBB3;MIR21;
GO:1901185 negative regulation of ERBB signaling pa… 10 6 2.62 163 0.02460 0.02460 ERRFI1;CBLB;ITGA1;PTPRJ;PTPRJ;NA;
GO:0002347 response to tumor cell 10 6 2.62 164 0.02460 0.02460 MICA;MICA;CD274;MICA;MICA;MICA;
GO:0055078 sodium ion homeostasis 10 6 2.62 165 0.02460 0.02460 NPPB;SPX;EDNRB;EDNRB;NEDD4L;ATP1A3; 
write.csv(res_top_GO, "pairwise_test_results/tGF.cGF/tGF.cGF.GO.enrichment.csv")

This is a ranking of which GO terms are enriched according to two different testing strategies, elim and Fisher.classic. these are, roughly, probability scores and can be broadly interpreted the same way as p-scores.

14. Visualizing the results:

nodes <- showSigOfNodes(top_GO_data, score(result_top_GO_elim), firstSigNodes = 3,
               useInfo = 'def')

png("pairwise_test_results/tGF.cGF/tGFR.tGFC.GO.nodes.png")
nodes
## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 59 
## Number of Edges = 122 
## 
## $complete.dag
## [1] "A graph with 59 nodes."
dev.off()
## png 
##   2
nodes
## $dag
## A graphNEL graph with directed edges
## Number of Nodes = 59 
## Number of Edges = 122 
## 
## $complete.dag
## [1] "A graph with 59 nodes."

15. Pathway enrichment analysis via Reactome

Reactome maps

library(reactome.db)
library(DOSE)
library(ReactomePA)
entrez_ids <- mapIds(hta20transcriptcluster.db, 
      keys = rownames(eset), 
      keytype = "PROBEID",
      column = "ENTREZID",
      multiVals = "first")

reactome_enrich <- enrichPathway(gene = entrez_ids[diff.probe], 
                                universe = entrez_ids[c(diff.probe, 
                                                        back.genes)],
                                organism = "human",
                                pvalueCutoff = 1,
                                qvalueCutoff = 1, 
                                readable = TRUE)

reactome_enrich@result$Description <- paste0(str_sub(
                                    reactome_enrich@result$Description, 1, 20),
                                    "...")

write.csv(as.data.frame(reactome_enrich), "pairwise_test_results/tGF.cGF/tGF.cGF.reactome.enrichment.csv")

kable(reactome_enrich) %>%
  kable_styling() %>%
  scroll_box(width = "100%", height = "400px")
ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
R-HSA-196849 R-HSA-196849 Metabolism of water-… 8/311 13/1154 0.0088672 0.9985851 0.9985851 SLC2A3/ENPP1/NT5E/SLC19A2/NMRK1/MTR/NMNAT2/MOCOS 8
R-HSA-196854 R-HSA-196854 Metabolism of vitami… 12/311 24/1154 0.0126278 0.9985851 0.9985851 SLC2A3/ENPP1/NT5E/SLC19A2/NMRK1/MTR/COQ7/AKR1B10/NMNAT2/BCO2/LRP12/MOCOS 12
R-HSA-2565942 R-HSA-2565942 Regulation of PLK1 A… 7/311 12/1154 0.0210717 0.9985851 0.9985851 PLK1/CCNB1/AURKA/PRKAR2B/CCNB2/CUL1/CCP110 7
R-HSA-6811558 R-HSA-6811558 PI5P, PP2A and IER3 … 6/311 11/1154 0.0477284 0.9985851 0.9985851 IER3/HBEGF/ERBB3/FYN/IL1RAP/PIK3R3 6
R-HSA-3214847 R-HSA-3214847 HATs acetylate histo… 10/311 23/1154 0.0629562 0.9985851 0.9985851 KAT6B/CREBBP/JADE2/HCFC1/NCOA2/WDR5/MSL1/CLOCK/TRRAP/USP22 10
R-HSA-198933 R-HSA-198933 Immunoregulatory int… 6/311 13/1154 0.1078776 0.9985851 0.9985851 CLEC2B/SLAMF7/MICA/ULBP1/MICB/ULBP3 6
R-HSA-199418 R-HSA-199418 Negative regulation … 6/311 13/1154 0.1078776 0.9985851 0.9985851 IER3/HBEGF/ERBB3/FYN/IL1RAP/PIK3R3 6
R-HSA-202403 R-HSA-202403 TCR signaling… 6/311 13/1154 0.1078776 0.9985851 0.9985851 PAG1/PAK3/HLA-DQB1/RIPK2/PTPRJ/CUL1 6
R-HSA-1655829 R-HSA-1655829 Regulation of choles… 5/311 11/1154 0.1472988 0.9985851 0.9985851 CREBBP/IDI1/HMGCS1/NCOA2/INSIG2 5
R-HSA-170834 R-HSA-170834 Signaling by TGF-bet… 6/311 14/1154 0.1477545 0.9985851 0.9985851 TGFBR2/JUNB/PPP1R15A/TFDP1/SKIL/NEDD4L 6
R-HSA-2980766 R-HSA-2980766 Nuclear Envelope Bre… 6/311 14/1154 0.1477545 0.9985851 0.9985851 PLK1/CCNB1/LMNB1/CCNB2/NUP188/POM121 6
R-HSA-425407 R-HSA-425407 SLC-mediated transme… 12/311 33/1154 0.1498729 0.9985851 0.9985851 SLCO4C1/SLC2A3/SLC7A2/SLC12A2/SLC12A3/SLC2A12/SLC2A14/SLC30A1/SLC9A2/SLC4A8/SLC2A13/SLC6A9 12
R-HSA-453274 R-HSA-453274 Mitotic G2-G2/M phas… 10/311 27/1154 0.1638475 0.9985851 0.9985851 PLK1/CCNB1/AURKA/PRKAR2B/CCNB2/FOXM1/PHLDA1/CUL1/CCNA2/CCP110 10
R-HSA-69275 R-HSA-69275 G2/M Transition… 10/311 27/1154 0.1638475 0.9985851 0.9985851 PLK1/CCNB1/AURKA/PRKAR2B/CCNB2/FOXM1/PHLDA1/CUL1/CCNA2/CCP110 10
R-HSA-8957322 R-HSA-8957322 Metabolism of steroi… 9/311 24/1154 0.1711709 0.9985851 0.9985851 VDR/OSBPL3/CREBBP/OSBPL6/IDI1/HMGCS1/NCOA2/SLC27A2/INSIG2 9
R-HSA-446652 R-HSA-446652 Interleukin-1 family… 8/311 21/1154 0.1786275 0.9985851 0.9985851 PTPN13/IL18/IL1A/PELI1/IL1RAP/PTPN9/RIPK2/CUL1 8
R-HSA-194840 R-HSA-194840 Rho GTPase cycle… 7/311 18/1154 0.1860662 0.9985851 0.9985851 ARHGAP23/CHN1/ARHGAP29/ARHGAP11B/SRGAP2/RHOB/ARHGAP11A 7
R-HSA-373760 R-HSA-373760 L1CAM interactions… 6/311 15/1154 0.1931894 0.9985851 0.9985851 SCN9A/ALCAM/RPS6KA6/ITGA1/ITGB3/RPS6KA3 6
R-HSA-416476 R-HSA-416476 G alpha (q) signalli… 6/311 15/1154 0.1931894 0.9985851 0.9985851 HBEGF/DGKA/EDNRB/RPS6KA3/P2RY1/PIK3R3 6
R-HSA-174143 R-HSA-174143 APC/C-mediated degra… 5/311 12/1154 0.1993801 0.9985851 0.9985851 PLK1/CCNB1/AURKA/CUL1/CCNA2 5
R-HSA-453276 R-HSA-453276 Regulation of mitoti… 5/311 12/1154 0.1993801 0.9985851 0.9985851 PLK1/CCNB1/AURKA/CUL1/CCNA2 5
R-HSA-556833 R-HSA-556833 Metabolism of lipids… 29/311 94/1154 0.2193159 0.9985851 0.9985851 ELOVL4/GDPD1/VDR/CDS1/OSBPL3/ACER2/AHR/CREBBP/LPCAT2/PTPN13/ACSL3/OSBPL6/IDI1/HMGCS1/NCOA2/NUDT19/PLEKHA6/SLC27A2/NEU1/ARSK/ELOVL7/CLOCK/PNPLA8/UGCG/INSIG2/MED12/PIK3R3/ACSM3/PLA2G12A 29
R-HSA-449147 R-HSA-449147 Signaling by Interle… 18/311 56/1154 0.2257459 0.9985851 0.9985851 FN1/LMNB1/PTPN13/LIFR/IL18/IL1A/PELI1/JUN/JUNB/RPS6KA3/IL6/FYN/PTK2B/IL1RAP/PTPN9/RIPK2/CUL1/PIK3R3 18
R-HSA-9006936 R-HSA-9006936 Signaling by TGF-bet… 7/311 19/1154 0.2304298 0.9985851 0.9985851 TGFBR2/JUNB/PPP1R15A/INHBA/TFDP1/SKIL/NEDD4L 7
R-HSA-373076 R-HSA-373076 Class A/1 (Rhodopsin… 6/311 16/1154 0.2430919 0.9985851 0.9985851 EDNRB/S1PR3/NPY1R/PTGER4/P2RY1/SSTR2 6
R-HSA-597592 R-HSA-597592 Post-translational p… 51/311 174/1154 0.2500822 0.9985851 0.9985851 MAN1A1/FN1/TNFAIP3/VDR/RAB3B/THBS1/ST3GAL1/CREBBP/STAG1/AURKA/HCFC1/EPAS1/NR4A2/TTLL7/TGFBR2/KDM1B/AGTPBP1/NCOA2/ALG14/NEU1/ARSK/FBXO32/WDR5/RAB30/ADAMTS1/ULBP2/COG7/RAB8B/CPM/B3GNT2/IL6/TRRAP/LRRC41/BIRC3/USP22/RAB11B/UBE2H/RIPK2/MITF/DDX58/CUL1/NUP188/POLB/LY6K/CCNA2/POM121/GPLD1/USP2/TFAP2A/CHML/CCP110 51
R-HSA-3247509 R-HSA-3247509 Chromatin modifying … 16/311 50/1154 0.2506381 0.9985851 0.9985851 ARID5B/KAT6B/ARID4A/CREBBP/JADE2/HCFC1/NSD1/KDM1B/SMARCB1/NCOA2/WDR5/MSL1/CLOCK/ARID1B/TRRAP/USP22 16
R-HSA-4839726 R-HSA-4839726 Chromatin organizati… 16/311 50/1154 0.2506381 0.9985851 0.9985851 ARID5B/KAT6B/ARID4A/CREBBP/JADE2/HCFC1/NSD1/KDM1B/SMARCB1/NCOA2/WDR5/MSL1/CLOCK/ARID1B/TRRAP/USP22 16
R-HSA-422475 R-HSA-422475 Axon guidance… 18/311 57/1154 0.2525164 0.9985851 0.9985851 SCN9A/PAK3/GFRA1/DAB1/ALCAM/RPS6KA6/ITGA1/ITGB3/EPHA7/CACNB4/RPS6KA3/ROBO1/FYN/FLRT3/SRGAP2/PIK3R3/EIF4G1/RHOB 18
R-HSA-388841 R-HSA-388841 Costimulation by the… 5/311 13/1154 0.2565691 0.9985851 0.9985851 PAK3/HLA-DQB1/FYN/PIK3R3/CD274 5
R-HSA-425393 R-HSA-425393 Transport of inorgan… 5/311 13/1154 0.2565691 0.9985851 0.9985851 SLC7A2/SLC12A2/SLC12A3/SLC9A2/SLC4A8 5
R-HSA-1483257 R-HSA-1483257 Phospholipid metabol… 8/311 23/1154 0.2614981 0.9985851 0.9985851 GDPD1/CDS1/LPCAT2/PTPN13/PLEKHA6/PNPLA8/PIK3R3/PLA2G12A 8
R-HSA-1234174 R-HSA-1234174 Regulation of Hypoxi… 4/311 10/1154 0.2706930 0.9985851 0.9985851 CREBBP/EPAS1/CITED2/EGLN3 4
R-HSA-1483255 R-HSA-1483255 PI Metabolism… 4/311 10/1154 0.2706930 0.9985851 0.9985851 GDPD1/PTPN13/PLEKHA6/PIK3R3 4
R-HSA-2262749 R-HSA-2262749 Cellular response to… 4/311 10/1154 0.2706930 0.9985851 0.9985851 CREBBP/EPAS1/CITED2/EGLN3 4
R-HSA-448424 R-HSA-448424 Interleukin-17 signa… 4/311 10/1154 0.2706930 0.9985851 0.9985851 JUN/RPS6KA3/RIPK2/CUL1 4
R-HSA-450294 R-HSA-450294 MAP kinase activatio… 4/311 10/1154 0.2706930 0.9985851 0.9985851 JUN/RPS6KA3/RIPK2/CUL1 4
R-HSA-8854518 R-HSA-8854518 AURKA Activation by … 4/311 10/1154 0.2706930 0.9985851 0.9985851 PLK1/AURKA/PRKAR2B/CCP110 4
R-HSA-8864260 R-HSA-8864260 Transcriptional regu… 4/311 10/1154 0.2706930 0.9985851 0.9985851 KCTD15/CREBBP/CITED2/TFAP2A 4
R-HSA-1474244 R-HSA-1474244 Extracellular matrix… 11/311 34/1154 0.2930413 0.9985851 0.9985851 FN1/THBS1/ITGA1/ITGB3/ADAM12/ADAMTS1/P3H2/LUM/COL14A1/SERPINH1/MMP12 11
R-HSA-1630316 R-HSA-1630316 Glycosaminoglycan me… 6/311 17/1154 0.2962235 0.9985851 0.9985851 DSEL/HPSE/ST3GAL1/B3GNT2/LUM/GLCE 6
R-HSA-2559582 R-HSA-2559582 Senescence-Associate… 6/311 17/1154 0.2962235 0.9985851 0.9985851 IL1A/JUN/RPS6KA3/IL6/CDKN2C/CCNA2 6
R-HSA-112314 R-HSA-112314 Neurotransmitter rec… 5/311 14/1154 0.3170217 0.9985851 0.9985851 GRIP1/RPS6KA6/MYO6/RPS6KA3/GABRB2 5
R-HSA-168142 R-HSA-168142 Toll Like Receptor 1… 5/311 14/1154 0.3170217 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-168176 R-HSA-168176 Toll Like Receptor 5… 5/311 14/1154 0.3170217 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-72306 R-HSA-72306 tRNA processing… 5/311 14/1154 0.3170217 0.9985851 0.9985851 TYW3/XPOT/PUS7/NUP188/POM121 5
R-HSA-975871 R-HSA-975871 MyD88 cascade initia… 5/311 14/1154 0.3170217 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-1280218 R-HSA-1280218 Adaptive Immune Syst… 24/311 81/1154 0.3272504 0.9985851 0.9985851 PAG1/CLEC2B/PAK3/KIF20A/SLAMF7/MICA/BTN2A2/HLA-DQB1/FBXO32/ULBP1/LRRC41/FYN/MICB/DTX3L/CBLB/UBE2H/RIPK2/PTPRJ/CUL1/TRIM9/NEDD4L/PIK3R3/ULBP3/CD274 24
R-HSA-176408 R-HSA-176408 Regulation of APC/C … 4/311 11/1154 0.3412040 0.9985851 0.9985851 PLK1/CCNB1/CUL1/CCNA2 4
R-HSA-936837 R-HSA-936837 Ion transport by P-t… 4/311 11/1154 0.3412040 0.9985851 0.9985851 ATP1A3/ATP2B1/ATP7A/ATP10D 4
R-HSA-1169410 R-HSA-1169410 Antiviral mechanism … 6/311 18/1154 0.3513022 0.9985851 0.9985851 IFIT1/OASL/DDX58/NUP188/POM121/EIF4G1 6
R-HSA-8856828 R-HSA-8856828 Clathrin-mediated en… 6/311 18/1154 0.3513022 0.9985851 0.9985851 SYT11/FNBP1L/REPS2/DNAJC6/KIAA0319/STON2 6
R-HSA-8978868 R-HSA-8978868 Fatty acid metabolis… 6/311 18/1154 0.3513022 0.9985851 0.9985851 ELOVL4/ACSL3/NUDT19/SLC27A2/ELOVL7/ACSM3 6
R-HSA-3108232 R-HSA-3108232 SUMO E3 ligases SUMO… 10/311 32/1154 0.3523036 0.9985851 0.9985851 VDR/CREBBP/STAG1/AURKA/NR4A2/NCOA2/MITF/NUP188/POM121/TFAP2A 10
R-HSA-5684996 R-HSA-5684996 MAPK1/MAPK3 signalin… 10/311 32/1154 0.3523036 0.9985851 0.9985851 FN1/GFRA1/DUSP1/HBEGF/ERBB3/ITGB3/PAQR3/IL6/FYN/DUSP5 10
R-HSA-68877 R-HSA-68877 Mitotic Prometaphase… 8/311 25/1154 0.3533253 0.9985851 0.9985851 PLK1/CCNB1/STAG1/PRKAR2B/CCNB2/CENPQ/CLIP1/CCP110 8
R-HSA-5688426 R-HSA-5688426 Deubiquitination… 13/311 43/1154 0.3664324 0.9985851 0.9985851 TNFAIP3/HCFC1/TGFBR2/KDM1B/TRRAP/BIRC3/USP22/RIPK2/DDX58/POLB/CCNA2/USP2/CCP110 13
R-HSA-5673001 R-HSA-5673001 RAF/MAP kinase casca… 9/311 29/1154 0.3752111 0.9985851 0.9985851 FN1/GFRA1/DUSP1/HBEGF/ERBB3/ITGB3/PAQR3/FYN/DUSP5 9
R-HSA-166058 R-HSA-166058 MyD88:MAL(TIRAP) cas… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-168138 R-HSA-168138 Toll Like Receptor 9… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-168164 R-HSA-168164 Toll Like Receptor 3… 5/311 15/1154 0.3789378 0.9985851 0.9985851 JUN/RPS6KA3/BIRC3/RIPK2/CUL1 5
R-HSA-168179 R-HSA-168179 Toll Like Receptor T… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-168181 R-HSA-168181 Toll Like Receptor 7… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-168188 R-HSA-168188 Toll Like Receptor T… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-181438 R-HSA-181438 Toll Like Receptor 2… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-9020702 R-HSA-9020702 Interleukin-1 signal… 5/311 15/1154 0.3789378 0.9985851 0.9985851 IL1A/PELI1/IL1RAP/RIPK2/CUL1 5
R-HSA-975138 R-HSA-975138 TRAF6 mediated induc… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-975155 R-HSA-975155 MyD88 dependent casc… 5/311 15/1154 0.3789378 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/RIPK2/CUL1 5
R-HSA-1280215 R-HSA-1280215 Cytokine Signaling i… 28/311 98/1154 0.3923311 0.9985851 0.9985851 TNFRSF9/FN1/LMNB1/PTPN13/LIFR/IL18/IFIT1/OASL/IL1A/PELI1/HLA-DQB1/JUN/JUNB/RPS6KA3/IL6/IFIT2/BIRC3/FYN/PTK2B/IL1RAP/PTPN9/RIPK2/DDX58/CUL1/NUP188/PIK3R3/POM121/EIF4G1 28
R-HSA-2990846 R-HSA-2990846 SUMOylation… 10/311 33/1154 0.3942171 0.9985851 0.9985851 VDR/CREBBP/STAG1/AURKA/NR4A2/NCOA2/MITF/NUP188/POM121/TFAP2A 10
R-HSA-166016 R-HSA-166016 Toll Like Receptor 4… 6/311 19/1154 0.4070895 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/BIRC3/RIPK2/CUL1 6
R-HSA-2500257 R-HSA-2500257 Resolution of Sister… 6/311 19/1154 0.4070895 0.9985851 0.9985851 PLK1/CCNB1/STAG1/CCNB2/CENPQ/CLIP1 6
R-HSA-397014 R-HSA-397014 Muscle contraction… 6/311 19/1154 0.4070895 0.9985851 0.9985851 SCN9A/TMOD2/ATP1A3/ATP2B1/ITGA1/CACNB4 6
R-HSA-5663220 R-HSA-5663220 RHO GTPases Activate… 6/311 19/1154 0.4070895 0.9985851 0.9985851 PLK1/CENPQ/CLIP1/SRGAP2/DAAM1/RHOB 6
R-HSA-163125 R-HSA-163125 Post-translational m… 4/311 12/1154 0.4121159 0.9985851 0.9985851 ULBP2/CPM/LY6K/GPLD1 4
R-HSA-5173105 R-HSA-5173105 O-linked glycosylati… 4/311 12/1154 0.4121159 0.9985851 0.9985851 THBS1/ST3GAL1/ADAMTS1/B3GNT2 4
R-HSA-5576891 R-HSA-5576891 Cardiac conduction… 4/311 12/1154 0.4121159 0.9985851 0.9985851 SCN9A/ATP1A3/ATP2B1/CACNB4 4
R-HSA-418594 R-HSA-418594 G alpha (i) signalli… 9/311 30/1154 0.4197800 0.9985851 0.9985851 PDE1A/PRKAR2B/S1PR3/NPY1R/RGS4/AKR1B10/BCO2/LRP12/SSTR2 9
R-HSA-166166 R-HSA-166166 MyD88-independent TL… 5/311 16/1154 0.4406859 0.9985851 0.9985851 JUN/RPS6KA3/BIRC3/RIPK2/CUL1 5
R-HSA-937061 R-HSA-937061 TRIF(TICAM1)-mediate… 5/311 16/1154 0.4406859 0.9985851 0.9985851 JUN/RPS6KA3/BIRC3/RIPK2/CUL1 5
R-HSA-112316 R-HSA-112316 Neuronal System… 8/311 27/1154 0.4481986 0.9985851 0.9985851 GRIP1/RPS6KA6/KCNV1/CACNB4/MYO6/RPS6KA3/IL1RAP/GABRB2 8
R-HSA-9006934 R-HSA-9006934 Signaling by Recepto… 17/311 60/1154 0.4526135 0.9985851 0.9985851 PAG1/FN1/PAK3/THBS1/HBEGF/ANOS1/ERBB3/ITGB3/TNS3/PDGFC/ADAM12/RPS6KA3/FYN/PTK2B/PTPRJ/FLRT3/PIK3R3 17
R-HSA-168898 R-HSA-168898 Toll-like Receptor C… 6/311 20/1154 0.4624555 0.9985851 0.9985851 PELI1/JUN/RPS6KA3/BIRC3/RIPK2/CUL1 6
R-HSA-5683057 R-HSA-5683057 MAPK family signalin… 12/311 42/1154 0.4643526 0.9985851 0.9985851 FN1/PAK3/GFRA1/DUSP1/HBEGF/ERBB3/ITGB3/JUN/PAQR3/IL6/FYN/DUSP5 12
R-HSA-382551 R-HSA-382551 Transport of small m… 25/311 90/1154 0.4694318 0.9985851 0.9985851 SLCO4C1/SLC2A3/SLC7A2/ABCG2/SLC12A2/SLC12A3/ATP1A3/SLC2A12/SLC2A14/PRKAR2B/CA2/ATP2B1/CREB3L3/SLC30A1/SLC9A2/ATP7A/SLC4A8/LIPA/SLC2A13/MLKL/ATP10D/CUL1/NEDD4L/SLC6A9/SGK3 25
R-HSA-1483206 R-HSA-1483206 Glycerophospholipid … 4/311 13/1154 0.4812478 0.9985851 0.9985851 CDS1/LPCAT2/PNPLA8/PLA2G12A 4
R-HSA-983168 R-HSA-983168 Antigen processing: … 8/311 28/1154 0.4950403 0.9985851 0.9985851 FBXO32/LRRC41/DTX3L/CBLB/UBE2H/CUL1/TRIM9/NEDD4L 8
R-HSA-1169408 R-HSA-1169408 ISG15 antiviral mech… 5/311 17/1154 0.5008786 0.9985851 0.9985851 IFIT1/DDX58/NUP188/POM121/EIF4G1 5
R-HSA-400253 R-HSA-400253 Circadian Clock… 5/311 17/1154 0.5008786 0.9985851 0.9985851 CREBBP/NCOA2/BHLHE41/CLOCK/CUL1 5
R-HSA-9007101 R-HSA-9007101 Rab regulation of tr… 5/311 17/1154 0.5008786 0.9985851 0.9985851 RAB8B/RAB11B/TBC1D14/DENND4A/CHML 5
R-HSA-112315 R-HSA-112315 Transmission across … 6/311 21/1154 0.5164219 0.9985851 0.9985851 GRIP1/RPS6KA6/CACNB4/MYO6/RPS6KA3/GABRB2 6
R-HSA-1989781 R-HSA-1989781 PPARA activates gene… 6/311 21/1154 0.5164219 0.9985851 0.9985851 AHR/CREBBP/HMGCS1/NCOA2/CLOCK/MED12 6
R-HSA-400206 R-HSA-400206 Regulation of lipid … 6/311 21/1154 0.5164219 0.9985851 0.9985851 AHR/CREBBP/HMGCS1/NCOA2/CLOCK/MED12 6
R-HSA-1474290 R-HSA-1474290 Collagen formation… 3/311 10/1154 0.5325909 0.9985851 0.9985851 P3H2/COL14A1/SERPINH1 3
R-HSA-1650814 R-HSA-1650814 Collagen biosynthesi… 3/311 10/1154 0.5325909 0.9985851 0.9985851 P3H2/COL14A1/SERPINH1 3
R-HSA-176814 R-HSA-176814 Activation of APC/C … 3/311 10/1154 0.5325909 0.9985851 0.9985851 PLK1/CCNB1/CCNA2 3
R-HSA-202424 R-HSA-202424 Downstream TCR signa… 3/311 10/1154 0.5325909 0.9985851 0.9985851 HLA-DQB1/RIPK2/CUL1 3
R-HSA-3000171 R-HSA-3000171 Non-integrin membran… 3/311 10/1154 0.5325909 0.9985851 0.9985851 FN1/THBS1/ITGB3 3
R-HSA-380320 R-HSA-380320 Recruitment of NuMA … 3/311 10/1154 0.5325909 0.9985851 0.9985851 PLK1/PRKAR2B/CCP110 3
R-HSA-425366 R-HSA-425366 Transport of bile sa… 3/311 10/1154 0.5325909 0.9985851 0.9985851 SLC30A1/SLC2A13/SLC6A9 3
R-HSA-4615885 R-HSA-4615885 SUMOylation of DNA r… 3/311 10/1154 0.5325909 0.9985851 0.9985851 AURKA/NUP188/POM121 3
R-HSA-69231 R-HSA-69231 Cyclin D associated … 3/311 10/1154 0.5325909 0.9985851 0.9985851 TFDP1/CDKN2C/CUL1 3
R-HSA-69236 R-HSA-69236 G1 Phase… 3/311 10/1154 0.5325909 0.9985851 0.9985851 TFDP1/CDKN2C/CUL1 3
R-HSA-199991 R-HSA-199991 Membrane Trafficking… 19/311 70/1154 0.5328799 0.9985851 0.9985851 MAN1A1/CUX1/SYT11/KIF20A/FNBP1L/REPS2/RAB30/MYO6/COG7/RAB8B/DNAJC6/KIAA0319/RAB11B/TBC1D14/STON2/VPS52/DENND4A/CHML/TBC1D8B 19
R-HSA-392499 R-HSA-392499 Metabolism of protei… 61/311 227/1154 0.5418379 0.9985851 0.9985851 KIF5C/MAN1A1/FN1/TNFAIP3/VDR/RAB3B/LMCD1/THBS1/ST3GAL1/CREBBP/STAG1/AURKA/ATF3/HCFC1/EPAS1/SEMG1/CREB3L3/NR4A2/TTLL7/TGFBR2/KDM1B/AGTPBP1/NCOA2/ALG14/NEU1/ARSK/FBXO32/WDR5/RAB30/ADAMTS1/ULBP2/COG7/RAB8B/CPM/B3GNT2/IL6/INHBA/WARS2/TRRAP/LRRC41/BIRC3/USP22/RAB11B/UBE2H/RIPK2/MITF/DDX58/CUL1/NUP188/POLB/LY6K/CCNA2/POM121/GPLD1/EIF4G1/USP2/TFAP2A/FKBP14/CHML/GATA6/CCP110 61
R-HSA-2262752 R-HSA-2262752 Cellular responses t… 17/311 63/1154 0.5476261 0.9985851 0.9985851 CREBBP/LMNB1/EPAS1/BAG2/GPX8/CITED2/IL1A/ATP7A/JUN/RPS6KA3/IL6/TFDP1/CDKN2C/NUP188/CCNA2/POM121/EGLN3 17
R-HSA-168256 R-HSA-168256 Immune System… 63/311 235/1154 0.5515663 0.9985851 0.9985851 SLPI/SLCO4C1/TNFRSF9/PAG1/SLC2A3/FN1/TNFAIP3/CLEC2B/PAK3/HPSE/KIF20A/SLAMF7/CREBBP/LMNB1/PTPN13/SEMG1/LIFR/IL18/IFIT1/MICA/OASL/BTN2A2/IL1A/PELI1/ATP7A/SLC27A2/HLA-DQB1/NEU1/KLRC2/FBXO32/CRISPLD2/CR2/JUN/JUNB/ULBP1/RPS6KA3/IL6/IFIT2/LRRC41/BIRC3/FYN/MICB/YPEL5/PTK2B/DTX3L/CBLB/IL1RAP/PTPN9/UBE2H/RIPK2/DDX58/PTPRJ/CUL1/TRIM9/NEDD4L/NUP188/PIK3R3/POM121/EIF4G1/LGALS3/ULBP3/CD274/GCA 63
R-HSA-388396 R-HSA-388396 GPCR downstream sign… 18/311 67/1154 0.5551262 0.9985851 0.9985851 PDE1A/HBEGF/DGKA/EDNRB/PRKAR2B/OR5AC2/S1PR3/NPY1R/RGS4/RPS6KA3/PTGER4/AKR1B10/BCO2/P2RY1/PIK3R3/LRP12/SSTR2/RHOB 18
R-HSA-162582 R-HSA-162582 Signal Transduction… 75/311 280/1154 0.5566258 0.9985851 0.9985851 SOX4/IER3/PAG1/FN1/PLK1/TNFAIP3/PAK3/GFRA1/PDE1A/DUSP1/THBS1/SFRP1/HBEGF/CREBBP/STAG1/DGKA/EDNRB/ANOS1/PRKAR2B/FAS/EPAS1/OR5AC2/S1PR3/ERBB3/ARHGAP23/ITGB3/NPY1R/SNAI2/TGFBR2/NCOA2/TNS3/PDGFC/JAG1/RGS4/CHN1/ADAM12/JUN/JUNB/RPS6KA3/PAQR3/PPP1R15A/IL6/INHBA/ZNF217/ARHGAP29/TFDP1/PTGER4/TRRAP/AKR1B10/SKIL/BIRC3/FYN/PTK2B/ARHGAP11B/DUSP5/CENPQ/IL1RAP/CLIP1/RIPK2/BCO2/P2RY1/PTPRJ/CUL1/FLRT3/SRGAP2/NEDD4L/PIK3R3/LRP12/DKK1/DAAM1/EIF4G1/USP2/SSTR2/RHOB/ARHGAP11A 75
R-HSA-3781865 R-HSA-3781865 Diseases of glycosyl… 5/311 18/1154 0.5584080 0.9985851 0.9985851 THBS1/ALG14/NEU1/ADAMTS1/LUM 5
R-HSA-6785807 R-HSA-6785807 Interleukin-4 and In… 5/311 18/1154 0.5584080 0.9985851 0.9985851 FN1/IL18/IL1A/JUNB/IL6 5
R-HSA-5653656 R-HSA-5653656 Vesicle-mediated tra… 19/311 71/1154 0.5622552 0.9985851 0.9985851 MAN1A1/CUX1/SYT11/KIF20A/FNBP1L/REPS2/RAB30/MYO6/COG7/RAB8B/DNAJC6/KIAA0319/RAB11B/TBC1D14/STON2/VPS52/DENND4A/CHML/TBC1D8B 19
R-HSA-500792 R-HSA-500792 GPCR ligand binding… 6/311 22/1154 0.5681853 0.9985851 0.9985851 EDNRB/S1PR3/NPY1R/PTGER4/P2RY1/SSTR2 6
R-HSA-6811442 R-HSA-6811442 Intra-Golgi and retr… 6/311 22/1154 0.5681853 0.9985851 0.9985851 MAN1A1/CUX1/KIF20A/RAB30/COG7/VPS52 6
R-HSA-983712 R-HSA-983712 Ion channel transpor… 7/311 26/1154 0.5768308 0.9985851 0.9985851 ATP1A3/ATP2B1/ATP7A/MLKL/ATP10D/NEDD4L/SGK3 7
R-HSA-194315 R-HSA-194315 Signaling by Rho GTP… 13/311 49/1154 0.5829403 0.9985851 0.9985851 PLK1/PAK3/ARHGAP23/NCOA2/CHN1/ARHGAP29/ARHGAP11B/CENPQ/CLIP1/SRGAP2/DAAM1/RHOB/ARHGAP11A 13
R-HSA-2559583 R-HSA-2559583 Cellular Senescence… 8/311 30/1154 0.5846567 0.9985851 0.9985851 LMNB1/IL1A/JUN/RPS6KA3/IL6/TFDP1/CDKN2C/CCNA2 8
R-HSA-5689880 R-HSA-5689880 Ub-specific processi… 8/311 30/1154 0.5846567 0.9985851 0.9985851 TRRAP/BIRC3/USP22/DDX58/POLB/CCNA2/USP2/CCP110 8
R-HSA-76002 R-HSA-76002 Platelet activation,… 8/311 30/1154 0.5846567 0.9985851 0.9985851 FN1/THBS1/DGKA/ITGB3/FYN/P2RY1/PIK3R3/RHOB 8
R-HSA-8953897 R-HSA-8953897 Cellular responses t… 19/311 72/1154 0.5909970 0.9985851 0.9985851 CREBBP/LMNB1/EPAS1/BAG2/GPX8/CITED2/IL1A/ATP7A/JUN/RPS6KA3/IL6/TFDP1/CDKN2C/NUP188/ATG4A/CCNA2/GABARAPL1/POM121/EGLN3 19
R-HSA-2644602 R-HSA-2644602 Signaling by NOTCH1 … 3/311 11/1154 0.6043610 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-2644603 R-HSA-2644603 Signaling by NOTCH1 … 3/311 11/1154 0.6043610 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-2644606 R-HSA-2644606 Constitutive Signali… 3/311 11/1154 0.6043610 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-2672351 R-HSA-2672351 Stimuli-sensing chan… 3/311 11/1154 0.6043610 0.9985851 0.9985851 MLKL/NEDD4L/SGK3 3
R-HSA-2894858 R-HSA-2894858 Signaling by NOTCH1 … 3/311 11/1154 0.6043610 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-2894862 R-HSA-2894862 Constitutive Signali… 3/311 11/1154 0.6043610 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-6806834 R-HSA-6806834 Signaling by MET… 3/311 11/1154 0.6043610 0.9985851 0.9985851 FN1/TNS3/PTPRJ 3
R-HSA-428157 R-HSA-428157 Sphingolipid metabol… 4/311 15/1154 0.6080294 0.9985851 0.9985851 ACER2/NEU1/ARSK/UGCG 4
R-HSA-4420097 R-HSA-4420097 VEGFA-VEGFR2 Pathway… 4/311 15/1154 0.6080294 0.9985851 0.9985851 PAK3/ITGB3/FYN/PTK2B 4
R-HSA-8856825 R-HSA-8856825 Cargo recognition fo… 4/311 15/1154 0.6080294 0.9985851 0.9985851 SYT11/REPS2/KIAA0319/STON2 4
R-HSA-9609507 R-HSA-9609507 Protein localization… 4/311 15/1154 0.6080294 0.9985851 0.9985851 NUDT19/SLC27A2/COA6/TIMM21 4
R-HSA-68875 R-HSA-68875 Mitotic Prophase… 6/311 23/1154 0.6171244 0.9985851 0.9985851 PLK1/CCNB1/LMNB1/CCNB2/NUP188/POM121 6
R-HSA-1430728 R-HSA-1430728 Metabolism… 61/311 232/1154 0.6285712 0.9985851 0.9985851 SAT1/ELOVL4/PGM2L1/DSEL/SLC2A3/GDPD1/VDR/CDS1/HPSE/OSBPL3/ABCG2/ST3GAL1/ACER2/AHR/CREBBP/LPCAT2/PTPN13/PRKAR2B/GMPR/SLC25A27/CA2/ACSL3/GLDC/ENPP1/NT5E/OSBPL6/IDI1/HMGCS1/NCOA2/NUDT19/PLEKHA6/SLC27A2/ETHE1/NEU1/ARSK/SLC19A2/NMRK1/MTR/ELOVL7/B3GNT2/CLOCK/COQ7/PNPLA8/UGCG/AKR1B10/NMNAT2/INSIG2/SRM/LUM/GLCE/BCO2/PDP1/UPP1/MED12/NUP188/PIK3R3/LRP12/ACSM3/POM121/MOCOS/PLA2G12A 61
R-HSA-71387 R-HSA-71387 Metabolism of carboh… 9/311 35/1154 0.6311645 0.9985851 0.9985851 PGM2L1/DSEL/HPSE/ST3GAL1/B3GNT2/LUM/GLCE/NUP188/POM121 9
R-HSA-372790 R-HSA-372790 Signaling by GPCR… 18/311 70/1154 0.6415587 0.9985851 0.9985851 PDE1A/HBEGF/DGKA/EDNRB/PRKAR2B/OR5AC2/S1PR3/NPY1R/RGS4/RPS6KA3/PTGER4/AKR1B10/BCO2/P2RY1/PIK3R3/LRP12/SSTR2/RHOB 18
R-HSA-73887 R-HSA-73887 Death Receptor Signa… 5/311 20/1154 0.6624485 0.9985851 0.9985851 TNFAIP3/FAS/BIRC3/RIPK2/USP2 5
R-HSA-8951664 R-HSA-8951664 Neddylation… 5/311 20/1154 0.6624485 0.9985851 0.9985851 EPAS1/FBXO32/WDR5/LRRC41/CUL1 5
R-HSA-159236 R-HSA-159236 Transport of Mature … 4/311 16/1154 0.6638105 0.9985851 0.9985851 U2AF2/NUP188/POM121/SRSF1 4
R-HSA-2219528 R-HSA-2219528 PI3K/AKT Signaling i… 4/311 16/1154 0.6638105 0.9985851 0.9985851 HBEGF/ERBB3/FYN/PIK3R3 4
R-HSA-168928 R-HSA-168928 DDX58/IFIH1-mediated… 3/311 12/1154 0.6684427 0.9985851 0.9985851 TNFAIP3/CREBBP/DDX58 3
R-HSA-1980143 R-HSA-1980143 Signaling by NOTCH1… 3/311 12/1154 0.6684427 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-3371453 R-HSA-3371453 Regulation of HSF1-m… 3/311 12/1154 0.6684427 0.9985851 0.9985851 BAG2/NUP188/POM121 3
R-HSA-375276 R-HSA-375276 Peptide ligand-bindi… 3/311 12/1154 0.6684427 0.9985851 0.9985851 EDNRB/NPY1R/SSTR2 3
R-HSA-5620912 R-HSA-5620912 Anchoring of the bas… 3/311 12/1154 0.6684427 0.9985851 0.9985851 PLK1/PRKAR2B/CCP110 3
R-HSA-69202 R-HSA-69202 Cyclin E associated … 3/311 12/1154 0.6684427 0.9985851 0.9985851 TFDP1/CUL1/CCNA2 3
R-HSA-69656 R-HSA-69656 Cyclin A:Cdk2-associ… 3/311 12/1154 0.6684427 0.9985851 0.9985851 TFDP1/CUL1/CCNA2 3
R-HSA-70171 R-HSA-70171 Glycolysis… 3/311 12/1154 0.6684427 0.9985851 0.9985851 PGM2L1/NUP188/POM121 3
R-HSA-8852276 R-HSA-8852276 The role of GTSE1 in… 3/311 12/1154 0.6684427 0.9985851 0.9985851 PLK1/CCNB1/CCNB2 3
R-HSA-1266738 R-HSA-1266738 Developmental Biolog… 26/311 102/1154 0.6746529 0.9985851 0.9985851 FLG/SCN9A/PAK3/GFRA1/CDH4/CREBBP/DAB1/ALCAM/EPAS1/RPS6KA6/ITGA1/ITGB3/EPHA7/NCOA2/CACNB4/WDR5/JUN/RPS6KA3/ROBO1/FYN/FLRT3/SRGAP2/MED12/PIK3R3/EIF4G1/RHOB 26
R-HSA-69278 R-HSA-69278 Cell Cycle, Mitotic… 19/311 76/1154 0.6972988 0.9985851 0.9985851 PLK1/KIF20A/CCNB1/STAG1/AURKA/LMNB1/PRKAR2B/CCNB2/TFDP1/FOXM1/CDKN2C/PHLDA1/CENPQ/CLIP1/CUL1/NUP188/CCNA2/POM121/CCP110 19
R-HSA-195258 R-HSA-195258 RHO GTPase Effectors… 8/311 33/1154 0.7029667 0.9985851 0.9985851 PLK1/PAK3/NCOA2/CENPQ/CLIP1/SRGAP2/DAAM1/RHOB 8
R-HSA-5617833 R-HSA-5617833 Cilium Assembly… 8/311 33/1154 0.7029667 0.9985851 0.9985851 PLK1/PRKAR2B/BBS7/IFT80/RP2/ARL6/TCTEX1D2/CCP110 8
R-HSA-376176 R-HSA-376176 Signaling by ROBO re… 5/311 21/1154 0.7080819 0.9985851 0.9985851 PAK3/ROBO1/FLRT3/SRGAP2/EIF4G1 5
R-HSA-72202 R-HSA-72202 Transport of Mature … 4/311 17/1154 0.7139434 0.9985851 0.9985851 U2AF2/NUP188/POM121/SRSF1 4
R-HSA-381340 R-HSA-381340 Transcriptional regu… 3/311 13/1154 0.7246011 0.9985851 0.9985851 CREBBP/NCOA2/MED12 3
R-HSA-5620920 R-HSA-5620920 Cargo trafficking to… 3/311 13/1154 0.7246011 0.9985851 0.9985851 BBS7/RP2/ARL6 3
R-HSA-5668541 R-HSA-5668541 TNFR2 non-canonical … 3/311 13/1154 0.7246011 0.9985851 0.9985851 TNFRSF9/BIRC3/CUL1 3
R-HSA-6804756 R-HSA-6804756 Regulation of TP53 A… 3/311 13/1154 0.7246011 0.9985851 0.9985851 TP53INP1/AURKA/CCNA2 3
R-HSA-70326 R-HSA-70326 Glucose metabolism… 3/311 13/1154 0.7246011 0.9985851 0.9985851 PGM2L1/NUP188/POM121 3
R-HSA-9013694 R-HSA-9013694 Signaling by NOTCH4… 3/311 13/1154 0.7246011 0.9985851 0.9985851 CREBBP/JAG1/CUL1 3
R-HSA-68886 R-HSA-68886 M Phase… 12/311 50/1154 0.7353918 0.9985851 0.9985851 PLK1/KIF20A/CCNB1/STAG1/LMNB1/PRKAR2B/CCNB2/CENPQ/CLIP1/NUP188/POM121/CCP110 12
R-HSA-8939211 R-HSA-8939211 ESR-mediated signali… 5/311 22/1154 0.7492279 0.9985851 0.9985851 CREBBP/STAG1/NCOA2/JUN/ZNF217 5
R-HSA-9018519 R-HSA-9018519 Estrogen-dependent g… 5/311 22/1154 0.7492279 0.9985851 0.9985851 CREBBP/STAG1/NCOA2/JUN/ZNF217 5
R-HSA-194138 R-HSA-194138 Signaling by VEGF… 4/311 18/1154 0.7583821 0.9985851 0.9985851 PAK3/ITGB3/FYN/PTK2B 4
R-HSA-5621481 R-HSA-5621481 C-type lectin recept… 4/311 18/1154 0.7583821 0.9985851 0.9985851 PAK3/CREBBP/FYN/CUL1 4
R-HSA-983231 R-HSA-983231 Factors involved in … 4/311 18/1154 0.7583821 0.9985851 0.9985851 KIF20A/PRKAR2B/DOCK4/GATA6 4
R-HSA-3700989 R-HSA-3700989 Transcriptional Regu… 13/311 55/1154 0.7618252 0.9985851 0.9985851 SESN3/GADD45A/TP53INP1/CCNB1/CREBBP/AURKA/FAS/PMAIP1/JUN/SESN2/TFDP1/CCNA2/USP2 13
R-HSA-141424 R-HSA-141424 Amplification of sig… 3/311 14/1154 0.7730546 0.9985851 0.9985851 PLK1/CENPQ/CLIP1 3
R-HSA-141444 R-HSA-141444 Amplification of si… 3/311 14/1154 0.7730546 0.9985851 0.9985851 PLK1/CENPQ/CLIP1 3
R-HSA-15869 R-HSA-15869 Metabolism of nucleo… 3/311 14/1154 0.7730546 0.9985851 0.9985851 GMPR/NT5E/UPP1 3
R-HSA-162599 R-HSA-162599 Late Phase of HIV Li… 3/311 14/1154 0.7730546 0.9985851 0.9985851 NEDD4L/NUP188/POM121 3
R-HSA-2454202 R-HSA-2454202 Fc epsilon receptor … 3/311 14/1154 0.7730546 0.9985851 0.9985851 JUN/FYN/CUL1 3
R-HSA-3108214 R-HSA-3108214 SUMOylation of DNA d… 3/311 14/1154 0.7730546 0.9985851 0.9985851 STAG1/NUP188/POM121 3
R-HSA-3214858 R-HSA-3214858 RMTs methylate histo… 3/311 14/1154 0.7730546 0.9985851 0.9985851 SMARCB1/WDR5/ARID1B 3
R-HSA-8876198 R-HSA-8876198 RAB GEFs exchange GT… 3/311 14/1154 0.7730546 0.9985851 0.9985851 RAB8B/DENND4A/CHML 3
R-HSA-5357801 R-HSA-5357801 Programmed Cell Deat… 6/311 27/1154 0.7780454 0.9985851 0.9985851 LMNB1/FAS/PMAIP1/TFDP1/BIRC3/MLKL 6
R-HSA-9006925 R-HSA-9006925 Intracellular signal… 10/311 44/1154 0.7904859 0.9985851 0.9985851 IER3/PDE1A/HBEGF/PRKAR2B/ERBB3/SNAI2/JUN/FYN/IL1RAP/PIK3R3 10
R-HSA-3371556 R-HSA-3371556 Cellular response to… 4/311 19/1154 0.7972972 0.9985851 0.9985851 CREBBP/BAG2/NUP188/POM121 4
R-HSA-69206 R-HSA-69206 G1/S Transition… 4/311 19/1154 0.7972972 0.9985851 0.9985851 CCNB1/TFDP1/CUL1/CCNA2 4
R-HSA-168274 R-HSA-168274 Export of Viral Ribo… 2/311 10/1154 0.7983028 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-211945 R-HSA-211945 Phase I - Functional… 2/311 10/1154 0.7983028 0.9985851 0.9985851 AHR/NCOA2 2
R-HSA-2122947 R-HSA-2122947 NOTCH1 Intracellular… 2/311 10/1154 0.7983028 0.9985851 0.9985851 CREBBP/CUL1 2
R-HSA-3214841 R-HSA-3214841 PKMTs methylate hist… 2/311 10/1154 0.7983028 0.9985851 0.9985851 NSD1/WDR5 2
R-HSA-3214842 R-HSA-3214842 HDMs demethylate his… 2/311 10/1154 0.7983028 0.9985851 0.9985851 ARID5B/KDM1B 2
R-HSA-418346 R-HSA-418346 Platelet homeostasis… 2/311 10/1154 0.7983028 0.9985851 0.9985851 PDE1A/ATP2B1 2
R-HSA-6802952 R-HSA-6802952 Signaling by BRAF an… 2/311 10/1154 0.7983028 0.9985851 0.9985851 FN1/ITGB3 2
R-HSA-6804757 R-HSA-6804757 Regulation of TP53 D… 2/311 10/1154 0.7983028 0.9985851 0.9985851 CCNA2/USP2 2
R-HSA-6806003 R-HSA-6806003 Regulation of TP53 E… 2/311 10/1154 0.7983028 0.9985851 0.9985851 CCNA2/USP2 2
R-HSA-68949 R-HSA-68949 Orc1 removal from ch… 2/311 10/1154 0.7983028 0.9985851 0.9985851 CUL1/CCNA2 2
R-HSA-162587 R-HSA-162587 HIV Life Cycle… 3/311 15/1154 0.8143109 0.9985851 0.9985851 NEDD4L/NUP188/POM121 3
R-HSA-1912408 R-HSA-1912408 Pre-NOTCH Transcript… 3/311 15/1154 0.8143109 0.9985851 0.9985851 CREBBP/JUN/TFDP1 3
R-HSA-2151201 R-HSA-2151201 Transcriptional acti… 3/311 15/1154 0.8143109 0.9985851 0.9985851 CREBBP/HCFC1/NCOA2 3
R-HSA-69618 R-HSA-69618 Mitotic Spindle Chec… 3/311 15/1154 0.8143109 0.9985851 0.9985851 PLK1/CENPQ/CLIP1 3
R-HSA-453279 R-HSA-453279 Mitotic G1-G1/S phas… 5/311 24/1154 0.8183258 0.9985851 0.9985851 CCNB1/TFDP1/CDKN2C/CUL1/CCNA2 5
R-HSA-195721 R-HSA-195721 Signaling by WNT… 7/311 33/1154 0.8290345 0.9985851 0.9985851 SOX4/SFRP1/CREBBP/TRRAP/CUL1/DKK1/DAAM1 7
R-HSA-202733 R-HSA-202733 Cell surface interac… 4/311 20/1154 0.8310094 0.9985851 0.9985851 FN1/ITGB3/FYN/GRB14 4
R-HSA-1640170 R-HSA-1640170 Cell Cycle… 19/311 83/1154 0.8397509 0.9985851 0.9985851 PLK1/KIF20A/CCNB1/STAG1/AURKA/LMNB1/PRKAR2B/CCNB2/TFDP1/FOXM1/CDKN2C/PHLDA1/CENPQ/CLIP1/CUL1/NUP188/CCNA2/POM121/CCP110 19
R-HSA-109688 R-HSA-109688 Cleavage of Growing … 2/311 11/1154 0.8414010 0.9985851 0.9985851 U2AF2/SRSF1 2
R-HSA-1268020 R-HSA-1268020 Mitochondrial protei… 2/311 11/1154 0.8414010 0.9985851 0.9985851 COA6/TIMM21 2
R-HSA-166520 R-HSA-166520 Signaling by NTRKs… 2/311 11/1154 0.8414010 0.9985851 0.9985851 RPS6KA3/FYN 2
R-HSA-168273 R-HSA-168273 Influenza Viral RNA … 2/311 11/1154 0.8414010 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-168276 R-HSA-168276 NS1 Mediated Effects… 2/311 11/1154 0.8414010 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-199992 R-HSA-199992 trans-Golgi Network … 2/311 11/1154 0.8414010 0.9985851 0.9985851 DNAJC6/TBC1D8B 2
R-HSA-201722 R-HSA-201722 Formation of the bet… 2/311 11/1154 0.8414010 0.9985851 0.9985851 CREBBP/TRRAP 2
R-HSA-3899300 R-HSA-3899300 SUMOylation of trans… 2/311 11/1154 0.8414010 0.9985851 0.9985851 CREBBP/NCOA2 2
R-HSA-421837 R-HSA-421837 Clathrin derived ves… 2/311 11/1154 0.8414010 0.9985851 0.9985851 DNAJC6/TBC1D8B 2
R-HSA-6802957 R-HSA-6802957 Oncogenic MAPK signa… 2/311 11/1154 0.8414010 0.9985851 0.9985851 FN1/ITGB3 2
R-HSA-69052 R-HSA-69052 Switching of origins… 2/311 11/1154 0.8414010 0.9985851 0.9985851 CUL1/CCNA2 2
R-HSA-72187 R-HSA-72187 mRNA 3’-end processi… 2/311 11/1154 0.8414010 0.9985851 0.9985851 U2AF2/SRSF1 2
R-HSA-73856 R-HSA-73856 RNA Polymerase II Tr… 2/311 11/1154 0.8414010 0.9985851 0.9985851 U2AF2/SRSF1 2
R-HSA-9010553 R-HSA-9010553 Regulation of expres… 2/311 11/1154 0.8414010 0.9985851 0.9985851 ROBO1/EIF4G1 2
R-HSA-948021 R-HSA-948021 Transport to the Gol… 2/311 11/1154 0.8414010 0.9985851 0.9985851 MAN1A1/COG7 2
R-HSA-983169 R-HSA-983169 Class I MHC mediated… 8/311 38/1154 0.8463727 0.9985851 0.9985851 FBXO32/LRRC41/DTX3L/CBLB/UBE2H/CUL1/TRIM9/NEDD4L 8
R-HSA-2555396 R-HSA-2555396 Mitotic Metaphase an… 5/311 25/1154 0.8466793 0.9985851 0.9985851 PLK1/STAG1/LMNB1/CENPQ/CLIP1 5
R-HSA-68882 R-HSA-68882 Mitotic Anaphase… 5/311 25/1154 0.8466793 0.9985851 0.9985851 PLK1/STAG1/LMNB1/CENPQ/CLIP1 5
R-HSA-1912422 R-HSA-1912422 Pre-NOTCH Expression… 3/311 16/1154 0.8490418 0.9985851 0.9985851 CREBBP/JUN/TFDP1 3
R-HSA-446193 R-HSA-446193 Biosynthesis of the … 3/311 16/1154 0.8490418 0.9985851 0.9985851 ST3GAL1/ALG14/NEU1 3
R-HSA-909733 R-HSA-909733 Interferon alpha/bet… 3/311 16/1154 0.8490418 0.9985851 0.9985851 IFIT1/OASL/IFIT2 3
R-HSA-1852241 R-HSA-1852241 Organelle biogenesis… 11/311 51/1154 0.8532435 0.9985851 0.9985851 PLK1/CREBBP/HCFC1/PRKAR2B/NCOA2/BBS7/IFT80/RP2/ARL6/TCTEX1D2/CCP110 11
R-HSA-211000 R-HSA-211000 Gene Silencing by RN… 4/311 21/1154 0.8599336 0.9985851 0.9985851 MYBL1/NUP188/POM121/TDRKH 4
R-HSA-69242 R-HSA-69242 S Phase… 4/311 21/1154 0.8599336 0.9985851 0.9985851 STAG1/TFDP1/CUL1/CCNA2 4
R-HSA-1257604 R-HSA-1257604 PIP3 activates AKT s… 8/311 39/1154 0.8671640 0.9985851 0.9985851 IER3/HBEGF/ERBB3/SNAI2/JUN/FYN/IL1RAP/PIK3R3 8
R-HSA-913531 R-HSA-913531 Interferon Signaling… 8/311 39/1154 0.8671640 0.9985851 0.9985851 IFIT1/OASL/HLA-DQB1/IFIT2/DDX58/NUP188/POM121/EIF4G1 8
R-HSA-5663202 R-HSA-5663202 Diseases of signal t… 12/311 56/1154 0.8676436 0.9985851 0.9985851 FN1/CUX1/HBEGF/CREBBP/ERBB3/ITGB3/TGFBR2/JAG1/FYN/CUL1/PIK3R3/DKK1 12
R-HSA-201681 R-HSA-201681 TCF dependent signal… 5/311 26/1154 0.8712849 0.9985851 0.9985851 SOX4/SFRP1/CREBBP/TRRAP/DKK1 5
R-HSA-9006931 R-HSA-9006931 Signaling by Nuclear… 5/311 26/1154 0.8712849 0.9985851 0.9985851 CREBBP/STAG1/NCOA2/JUN/ZNF217 5
R-HSA-168253 R-HSA-168253 Host Interactions wi… 2/311 12/1154 0.8759927 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-446219 R-HSA-446219 Synthesis of substra… 2/311 12/1154 0.8759927 0.9985851 0.9985851 ST3GAL1/NEU1 2
R-HSA-8943724 R-HSA-8943724 Regulation of PTEN g… 2/311 12/1154 0.8759927 0.9985851 0.9985851 SNAI2/JUN 2
R-HSA-2559580 R-HSA-2559580 Oxidative Stress Ind… 3/311 17/1154 0.8779914 0.9985851 0.9985851 JUN/TFDP1/CDKN2C 3
R-HSA-381119 R-HSA-381119 Unfolded Protein Res… 3/311 17/1154 0.8779914 0.9985851 0.9985851 ATF3/CREB3L3/FKBP14 3
R-HSA-5689603 R-HSA-5689603 UCH proteinases… 3/311 17/1154 0.8779914 0.9985851 0.9985851 HCFC1/TGFBR2/KDM1B 3
R-HSA-8878171 R-HSA-8878171 Transcriptional regu… 7/311 36/1154 0.8924537 0.9985851 0.9985851 THBS1/CREBBP/LIFR/SMARCB1/WDR5/ARID1B/LGALS3 7
R-HSA-114608 R-HSA-114608 Platelet degranulati… 3/311 18/1154 0.9019133 0.9985851 0.9985851 FN1/THBS1/ITGB3 3
R-HSA-1592230 R-HSA-1592230 Mitochondrial biogen… 3/311 18/1154 0.9019133 0.9985851 0.9985851 CREBBP/HCFC1/NCOA2 3
R-HSA-5617472 R-HSA-5617472 Activation of anteri… 3/311 18/1154 0.9019133 0.9985851 0.9985851 CREBBP/WDR5/JUN 3
R-HSA-5619507 R-HSA-5619507 Activation of HOX ge… 3/311 18/1154 0.9019133 0.9985851 0.9985851 CREBBP/WDR5/JUN 3
R-HSA-8878159 R-HSA-8878159 Transcriptional regu… 3/311 18/1154 0.9019133 0.9985851 0.9985851 CTGF/CREBBP/JAG1 3
R-HSA-8878166 R-HSA-8878166 Transcriptional regu… 3/311 18/1154 0.9019133 0.9985851 0.9985851 CCNB1/CUL1/LGALS3 3
R-HSA-1428517 R-HSA-1428517 The citric acid (TCA… 2/311 13/1154 0.9035184 0.9985851 0.9985851 SLC25A27/PDP1 2
R-HSA-1474165 R-HSA-1474165 Reproduction… 2/311 13/1154 0.9035184 0.9985851 0.9985851 STAG1/LMNB1 2
R-HSA-1500620 R-HSA-1500620 Meiosis… 2/311 13/1154 0.9035184 0.9985851 0.9985851 STAG1/LMNB1 2
R-HSA-212165 R-HSA-212165 Epigenetic regulatio… 2/311 13/1154 0.9035184 0.9985851 0.9985851 UBTF/PHF19 2
R-HSA-2132295 R-HSA-2132295 MHC class II antigen… 2/311 13/1154 0.9035184 0.9985851 0.9985851 KIF20A/HLA-DQB1 2
R-HSA-2559586 R-HSA-2559586 DNA Damage/Telomere … 2/311 13/1154 0.9035184 0.9985851 0.9985851 LMNB1/CCNA2 2
R-HSA-5610787 R-HSA-5610787 Hedgehog ‘off’ state… 2/311 13/1154 0.9035184 0.9985851 0.9985851 PRKAR2B/CUL1 2
R-HSA-5628897 R-HSA-5628897 TP53 Regulates Metab… 2/311 13/1154 0.9035184 0.9985851 0.9985851 SESN3/SESN2 2
R-HSA-69239 R-HSA-69239 Synthesis of DNA… 2/311 13/1154 0.9035184 0.9985851 0.9985851 CUL1/CCNA2 2
R-HSA-69306 R-HSA-69306 DNA Replication… 2/311 13/1154 0.9035184 0.9985851 0.9985851 CUL1/CCNA2 2
R-HSA-983705 R-HSA-983705 Signaling by the B C… 2/311 13/1154 0.9035184 0.9985851 0.9985851 FYN/CUL1 2
R-HSA-2467813 R-HSA-2467813 Separation of Sister… 4/311 23/1154 0.9052951 0.9985851 0.9985851 PLK1/STAG1/CENPQ/CLIP1 4
R-HSA-162909 R-HSA-162909 Host Interactions of… 3/311 19/1154 0.9215288 0.9985851 0.9985851 FYN/NUP188/POM121 3
R-HSA-211859 R-HSA-211859 Biological oxidation… 3/311 19/1154 0.9215288 0.9985851 0.9985851 AHR/NCOA2/MTR 3
R-HSA-76005 R-HSA-76005 Response to elevated… 3/311 19/1154 0.9215288 0.9985851 0.9985851 FN1/THBS1/ITGB3 3
R-HSA-109582 R-HSA-109582 Hemostasis… 16/311 77/1154 0.9216620 0.9985851 0.9985851 FN1/PDE1A/THBS1/KIF20A/DGKA/PRKAR2B/ATP2B1/ITGA1/ITGB3/DOCK4/FYN/P2RY1/PIK3R3/RHOB/GRB14/GATA6 16
R-HSA-162906 R-HSA-162906 HIV Infection… 4/311 24/1154 0.9226890 0.9985851 0.9985851 FYN/NEDD4L/NUP188/POM121 4
R-HSA-351202 R-HSA-351202 Metabolism of polyam… 2/311 14/1154 0.9252624 0.9985851 0.9985851 SAT1/SRM 2
R-HSA-8936459 R-HSA-8936459 RUNX1 regulates gene… 2/311 14/1154 0.9252624 0.9985851 0.9985851 THBS1/WDR5 2
R-HSA-109581 R-HSA-109581 Apoptosis… 4/311 25/1154 0.9371671 0.9985851 0.9985851 LMNB1/FAS/PMAIP1/TFDP1 4
R-HSA-418555 R-HSA-418555 G alpha (s) signalli… 3/311 20/1154 0.9375028 0.9985851 0.9985851 PDE1A/OR5AC2/PTGER4 3
R-HSA-168249 R-HSA-168249 Innate Immune System… 26/311 121/1154 0.9406788 0.9985851 0.9985851 SLPI/SLCO4C1/SLC2A3/TNFAIP3/PAK3/HPSE/CREBBP/SEMG1/PELI1/ATP7A/SLC27A2/NEU1/KLRC2/CRISPLD2/CR2/JUN/RPS6KA3/BIRC3/FYN/YPEL5/RIPK2/DDX58/PTPRJ/CUL1/LGALS3/GCA 26
R-HSA-72203 R-HSA-72203 Processing of Capped… 6/311 35/1154 0.9418928 0.9985851 0.9985851 RBMX/U2AF2/NUP188/POM121/FUS/SRSF1 6
R-HSA-168255 R-HSA-168255 Influenza Life Cycle… 2/311 15/1154 0.9423318 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-4551638 R-HSA-4551638 SUMOylation of chrom… 2/311 15/1154 0.9423318 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-5358351 R-HSA-5358351 Signaling by Hedgeho… 2/311 15/1154 0.9423318 0.9985851 0.9985851 PRKAR2B/CUL1 2
R-HSA-5687128 R-HSA-5687128 MAPK6/MAPK4 signalin… 2/311 15/1154 0.9423318 0.9985851 0.9985851 PAK3/JUN 2
R-HSA-74160 R-HSA-74160 Gene expression (Tra… 52/311 226/1154 0.9435636 0.9985851 0.9985851 SESN3/SLC2A3/GTF3C6/GADD45A/VDR/KCTD15/UBTF/THBS1/CTGF/TP53INP1/CCNB1/CREBBP/ELL2/AURKA/MYBL1/FAS/LIFR/PMAIP1/NR4A2/U2AF2/CITED2/SMARCB1/NABP1/ZNF711/JAG1/WDR5/JUN/JUNB/ZNF709/ZNF331/SESN2/EAF2/TFDP1/ARID1B/ZNF600/ZNF468/SKIL/ZNF160/CUL1/NFIB/PHF19/MED12/NEDD4L/NUP188/RPRD2/CCNA2/POM121/USP2/LGALS3/TFAP2A/SRSF1/TDRKH 52
R-HSA-6798695 R-HSA-6798695 Neutrophil degranula… 11/311 58/1154 0.9447306 0.9985851 0.9985851 SLPI/SLCO4C1/SLC2A3/HPSE/SLC27A2/NEU1/CRISPLD2/YPEL5/PTPRJ/LGALS3/GCA 11
R-HSA-72163 R-HSA-72163 mRNA Splicing - Majo… 4/311 26/1154 0.9491456 0.9985851 0.9985851 RBMX/U2AF2/FUS/SRSF1 4
R-HSA-72172 R-HSA-72172 mRNA Splicing… 4/311 26/1154 0.9491456 0.9985851 0.9985851 RBMX/U2AF2/FUS/SRSF1 4
R-HSA-157118 R-HSA-157118 Signaling by NOTCH… 5/311 31/1154 0.9499145 0.9985851 0.9985851 CREBBP/JAG1/JUN/TFDP1/CUL1 5
R-HSA-69620 R-HSA-69620 Cell Cycle Checkpoin… 6/311 36/1154 0.9517806 0.9985851 0.9985851 PLK1/CCNB1/CCNB2/CENPQ/CLIP1/CCNA2 6
R-HSA-5578749 R-HSA-5578749 Transcriptional regu… 2/311 16/1154 0.9556590 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-1168372 R-HSA-1168372 Downstream signaling… 1/311 10/1154 0.9573490 0.9985851 0.9985851 CUL1 1
R-HSA-163685 R-HSA-163685 Integration of energ… 1/311 10/1154 0.9573490 0.9985851 0.9985851 PRKAR2B 1
R-HSA-1834949 R-HSA-1834949 Cytosolic sensors of… 1/311 10/1154 0.9573490 0.9985851 0.9985851 CREBBP 1
R-HSA-193704 R-HSA-193704 p75 NTR receptor-med… 1/311 10/1154 0.9573490 0.9985851 0.9985851 RIPK2 1
R-HSA-195253 R-HSA-195253 Degradation of beta-… 1/311 10/1154 0.9573490 0.9985851 0.9985851 CUL1 1
R-HSA-3214815 R-HSA-3214815 HDACs deacetylate hi… 1/311 10/1154 0.9573490 0.9985851 0.9985851 ARID4A 1
R-HSA-381070 R-HSA-381070 IRE1alpha activates … 1/311 10/1154 0.9573490 0.9985851 0.9985851 FKBP14 1
R-HSA-4086400 R-HSA-4086400 PCP/CE pathway… 1/311 10/1154 0.9573490 0.9985851 0.9985851 DAAM1 1
R-HSA-447115 R-HSA-447115 Interleukin-12 famil… 1/311 10/1154 0.9573490 0.9985851 0.9985851 LMNB1 1
R-HSA-5668914 R-HSA-5668914 Diseases of metaboli… 1/311 10/1154 0.9573490 0.9985851 0.9985851 MTR 1
R-HSA-5693567 R-HSA-5693567 HDR through Homologo… 1/311 10/1154 0.9573490 0.9985851 0.9985851 CCNA2 1
R-HSA-73886 R-HSA-73886 Chromosome Maintenan… 1/311 10/1154 0.9573490 0.9985851 0.9985851 CENPQ 1
R-HSA-8986944 R-HSA-8986944 Transcriptional Regu… 1/311 10/1154 0.9573490 0.9985851 0.9985851 SLC2A3 1
R-HSA-977225 R-HSA-977225 Amyloid fiber format… 1/311 10/1154 0.9573490 0.9985851 0.9985851 SEMG1 1
R-HSA-877300 R-HSA-877300 Interferon gamma sig… 2/311 17/1154 0.9660146 0.9985851 0.9985851 OASL/HLA-DQB1 2
R-HSA-5633007 R-HSA-5633007 Regulation of TP53 A… 4/311 28/1154 0.9670685 0.9985851 0.9985851 TP53INP1/AURKA/CCNA2/USP2 4
R-HSA-5693538 R-HSA-5693538 Homology Directed Re… 1/311 11/1154 0.9689438 0.9985851 0.9985851 CCNA2 1
R-HSA-72312 R-HSA-72312 rRNA processing… 1/311 11/1154 0.9689438 0.9985851 0.9985851 RIOK3 1
R-HSA-8868773 R-HSA-8868773 rRNA processing in t… 1/311 11/1154 0.9689438 0.9985851 0.9985851 RIOK3 1
R-HSA-446203 R-HSA-446203 Asparagine N-linked … 5/311 34/1154 0.9728857 0.9985851 0.9985851 MAN1A1/ST3GAL1/ALG14/NEU1/COG7 5
R-HSA-8856688 R-HSA-8856688 Golgi-to-ER retrogra… 1/311 12/1154 0.9773939 0.9985851 0.9985851 KIF20A 1
R-HSA-73857 R-HSA-73857 RNA Polymerase II Tr… 44/311 204/1154 0.9786059 0.9985851 0.9985851 SESN3/SLC2A3/GADD45A/VDR/KCTD15/THBS1/CTGF/TP53INP1/CCNB1/CREBBP/ELL2/AURKA/FAS/LIFR/PMAIP1/NR4A2/U2AF2/CITED2/SMARCB1/NABP1/ZNF711/JAG1/WDR5/JUN/JUNB/ZNF709/ZNF331/SESN2/EAF2/TFDP1/ARID1B/ZNF600/ZNF468/SKIL/ZNF160/CUL1/MED12/NEDD4L/RPRD2/CCNA2/USP2/LGALS3/TFAP2A/SRSF1 44
R-HSA-8953854 R-HSA-8953854 Metabolism of RNA… 14/311 78/1154 0.9799843 0.9985851 0.9985851 TYW3/RBMX/U2AF2/DCPS/XPOT/PUS7/A1CF/SNUPN/RIOK3/NUP188/POM121/FUS/EIF4G1/SRSF1 14
R-HSA-168254 R-HSA-168254 Influenza Infection… 2/311 19/1154 0.9802036 0.9985851 0.9985851 NUP188/POM121 2
R-HSA-69481 R-HSA-69481 G2/M Checkpoints… 2/311 19/1154 0.9802036 0.9985851 0.9985851 CCNB1/CCNB2 2
R-HSA-72766 R-HSA-72766 Translation… 2/311 19/1154 0.9802036 0.9985851 0.9985851 WARS2/EIF4G1 2
R-HSA-5663205 R-HSA-5663205 Infectious disease… 5/311 36/1154 0.9822883 0.9985851 0.9985851 HBEGF/FYN/NEDD4L/NUP188/POM121 5
R-HSA-3858494 R-HSA-3858494 Beta-catenin indepen… 1/311 13/1154 0.9835502 0.9985851 0.9985851 DAAM1 1
R-HSA-212436 R-HSA-212436 Generic Transcriptio… 38/311 182/1154 0.9838412 0.9985851 0.9985851 SESN3/SLC2A3/GADD45A/VDR/KCTD15/THBS1/CTGF/TP53INP1/CCNB1/CREBBP/AURKA/FAS/LIFR/PMAIP1/NR4A2/CITED2/SMARCB1/ZNF711/JAG1/WDR5/JUN/JUNB/ZNF709/ZNF331/SESN2/TFDP1/ARID1B/ZNF600/ZNF468/SKIL/ZNF160/CUL1/MED12/NEDD4L/CCNA2/USP2/LGALS3/TFAP2A 38
R-HSA-71291 R-HSA-71291 Metabolism of amino … 5/311 37/1154 0.9857505 0.9985851 0.9985851 SAT1/GLDC/ETHE1/MTR/SRM 5
R-HSA-381753 R-HSA-381753 Olfactory Signaling … 1/311 14/1154 0.9880339 0.9985851 0.9985851 OR5AC2 1
R-HSA-5619115 R-HSA-5619115 Disorders of transme… 1/311 14/1154 0.9880339 0.9985851 0.9985851 SLC12A3 1
R-HSA-6807070 R-HSA-6807070 PTEN Regulation… 2/311 21/1154 0.9885815 0.9985851 0.9985851 SNAI2/JUN 2
R-HSA-1643685 R-HSA-1643685 Disease… 24/311 129/1154 0.9927325 0.9985851 0.9985851 FN1/CUX1/THBS1/HBEGF/CREBBP/SLC12A3/LMNB1/ERBB3/ITGB3/TGFBR2/ALG14/NEU1/JAG1/JUN/ADAMTS1/MTR/FYN/LUM/CUL1/NEDD4L/NUP188/PIK3R3/DKK1/POM121 24
R-HSA-450531 R-HSA-450531 Regulation of mRNA s… 1/311 16/1154 0.9936743 0.9985851 0.9985851 EIF4G1 1
R-HSA-5693532 R-HSA-5693532 DNA Double-Strand Br… 1/311 17/1154 0.9954030 0.9985851 0.9985851 CCNA2 1
R-HSA-73894 R-HSA-73894 DNA Repair… 3/311 35/1154 0.9985851 0.9985851 0.9985851 FANCB/POLB/CCNA2 3

16. Visualizing reactome results

Barplots, showing reaction categories represented and their respective p-values:

png("pairwise_test_results/tGF.cGF/tGF.cGF.reactome.barplot.png")
barplot(reactome_enrich)
dev.off()
## png 
##   2
barplot(reactome_enrich)

png("pairwise_test_results/tGF.cGF/tGF.cGF.reactome.emapplot.png")
emapplot(reactome_enrich, showCategory = 10)
dev.off()
## png 
##   2
emapplot(reactome_enrich, showCategory = 10)

In this plot, color is p-value, size is proportional to the number of DE genes that mapped to the pathway, and the edge thickness is proportional to the number of shared genes between the units. This is useful for examining the interdependence of the pathways; which results should be taken more serioiusly, are independent? This particular plot shows the top ten most significant pathways, regardless of their p-values