Patients Analysis

The following table showing the number and the percentages of patients splitted into first (initial) visit and his remaining visits:

Table 1
[ALL] N
N=9149
IDD: 9149
Initial Visit 1628 (17.8%)
Remaining Visit(s) 7521 (82.2%)

The next table shows the percentages of

Table 2
[ALL] N
N=1573
Gender: 1573
female 977 (62.1%)
male 596 (37.9%)
age_years 53.3 (12.5) 1557
age_Diagnosis 8.49 (6.64) 1358
RF: 1447
Negative 330 (22.8%)
Positive 1117 (77.2%)
CCP: 1252
Negative 435 (34.7%)
Positive 817 (65.3%) 
plot(r2, n.breaks = "Sturges", perc = FALSE)

Nationality

## tbfs$nationality.G : 
##               Frequency Percent Cum. percent
## non-Kuwaiti's       819    50.1         50.1
## Kuwaiti's           816    49.9        100.0
##   Total            1635   100.0        100.0
## Warning in data(tbfs): data set 'tbfs' not found

Distribution of DMARD’s

DMARDS Freq bar_label highlight_bar
MTX 1037 1,037, 48.1% 1037
SSZ 275 275, 12.8% 0
LEF 240 240, 11.1% 0
HCQ 566 566, 26.3% 0
IMUR 36 36, 1.7% 0
CYC 1 1, 0.0% 0

Biologics

A caption

A caption 

## 
## Attaching package: 'summarytools'
## The following objects are masked from 'package:xtable':
## 
##     label, label<-
## The following objects are masked from 'package:Hmisc':
## 
##     label, label<-
## tbl$onbio : 
##         Frequency Percent Cum. percent
## No            978    62.2         62.2
## Yes           595    37.8        100.0
##   Total      1573   100.0        100.0

Biologics Frequancies from Last visit

Biologics Freq bar_label highlight_bar
RIT 160 160, 26.8% 160
ADA 122 122, 20.4% 0
TOC 90 90, 15.1% 0
ETA 85 85, 14.2% 0
ABA 49 49, 8.2% 0
INF 28 28, 4.7% 0
TOF 24 24, 4.0% 0
CER 26 26, 4.4% 0
GOL 13 13, 2.2% 0

Biologics usage by Nationality level

Table 3
Kuwaiti’s non-Kuwaiti’s p.overall
N=780 N=793
BioMono: <0.001
Combination 318 (40.8%) 93 (11.7%)
Monotherapy 170 (21.8%) 14 (1.77%)
No 292 (37.4%) 686 (86.5%)
BioMono2: <0.001
Combination 318 (65.2%) 93 (86.9%)
Monotherapy 170 (34.8%) 14 (13.1%)
RIT 133 (17.1%) 27 (3.40%) <0.001
ADA 99 (12.7%) 23 (2.90%) <0.001
TOC 79 (10.1%) 11 (1.39%) <0.001
ETA 58 (7.44%) 27 (3.40%) 0.001
ABA 46 (5.90%) 3 (0.38%) <0.001
INF 27 (3.46%) 1 (0.13%) <0.001
TOF 20 (2.56%) 4 (0.50%) 0.002
CER 23 (2.95%) 3 (0.38%) <0.001
GOL 5 (0.64%) 8 (1.01%) 0.598
Table 4
[ALL] N
N=1573
DAS28 2.76 (1.24) 1566
SDAI 6.52 (9.98) 1478
CDAI 6.52 (9.98) 1478
VAS 1.74 (2.45) 1573
CRP 6.58 (13.5) 617
ESR 17.8 (25.2) 253
Hgb 108 (56.2) 1465
MorningS 9.53 (17.5) 850
Tender 3.03 (5.70) 1573
Swollen 0.75 (2.42) 1573
HAQ2 0.78 (0.73) 652
Table 4
Kuwaiti’s non-Kuwaiti’s p.overall
N=780 N=793
DAS28 2.71 (1.23) 2.81 (1.24) 0.109
SDAI 6.62 (10.5) 6.42 (9.47) 0.701
CDAI 6.62 (10.5) 6.42 (9.47) 0.701
VAS 1.86 (2.54) 1.62 (2.35) 0.051
CRP 5.84 (10.6) 7.30 (15.8) 0.177
ESR 17.1 (23.2) 18.5 (27.1) 0.662
Hgb 108 (62.6) 108 (48.8) 0.957
MorningS 8.13 (14.9) 11.5 (20.5) 0.008
Tender 3.31 (6.25) 2.77 (5.09) 0.059
Swollen 0.43 (1.74) 1.06 (2.91) <0.001
Gender: <0.001
female 561 (71.9%) 416 (52.5%)
male 219 (28.1%) 377 (47.5%)
age_years 55.9 (13.3) 50.9 (11.2) <0.001
age_Diagnosis 9.74 (7.46) 7.21 (5.39) <0.001
HAQ2 0.88 (0.76) 0.57 (0.62) <0.001 

## 
## ========================================================
##                      tbl$BioMono2
## tbl$nationality.G    Combination   Monotherapy     Total
## --------------------------------------------------------
## Kuwaiti's                   318           170       488 
## chisq                     1.081         2.415           
## row %                    65.164%       34.836%   82.017%
## col %                    77.372%       92.391%          
## table %                  53.445%       28.571%          
## --------------------------------------------------------
## non-Kuwaiti's                93            14       107 
## chisq                     4.930        11.012           
## row %                    86.916%       13.084%   17.983%
## col %                    22.628%        7.609%          
## table %                  15.630%        2.353%          
## --------------------------------------------------------
## Total                       411           184       595 
##                          69.076%       30.924%          
## ========================================================
## 
## Statistics for All Table Factors
## 
## Pearson's Chi-squared test 
## ------------------------------------------------------------
## Chi^2 = 19.43826      d.f. = 1      p = 1.04e-05 
## 
## Pearson's Chi-squared test with Yates' continuity correction 
## ------------------------------------------------------------
## Chi^2 = 18.43331      d.f. = 1      p = 1.76e-05 
##         Minimum expected frequency: 33.08908

Table 3
Combination Monotherapy No p.overall
N=411 N=184 N=978
RIT 107 (26.0%) 53 (28.8%) 0 (0.00%) <0.001
ADA 107 (26.0%) 15 (8.15%) 0 (0.00%) <0.001
TOC 47 (11.4%) 43 (23.4%) 0 (0.00%) <0.001
ETA 62 (15.1%) 23 (12.5%) 0 (0.00%) <0.001
ABA 31 (7.54%) 18 (9.78%) 0 (0.00%) <0.001
INF 20 (4.87%) 8 (4.35%) 0 (0.00%) <0.001
TOF 13 (3.16%) 11 (5.98%) 0 (0.00%) <0.001
CER 15 (3.65%) 11 (5.98%) 0 (0.00%) <0.001
GOL 11 (2.68%) 2 (1.09%) 0 (0.00%) <0.001
Table 3
Combination Monotherapy p.overall
N=411 N=184
RIT 107 (26.0%) 53 (28.8%) 0.546
ADA 107 (26.0%) 15 (8.15%) <0.001
TOC 47 (11.4%) 43 (23.4%) <0.001
ETA 62 (15.1%) 23 (12.5%) 0.480
ABA 31 (7.54%) 18 (9.78%) 0.449
INF 20 (4.87%) 8 (4.35%) 0.947
TOF 13 (3.16%) 11 (5.98%) 0.165
CER 15 (3.65%) 11 (5.98%) 0.286
GOL 11 (2.68%) 2 (1.09%) 0.363
Table 3
Combination Monotherapy p.overall
N=411 N=184
DAS28 2.72 (1.25) 2.67 (1.25) 0.677
SDAI 6.75 (10.4) 7.72 (11.4) 0.337
CDAI 6.75 (10.4) 7.72 (11.4) 0.337
VAS 1.89 (2.51) 2.23 (2.85) 0.161
CRP 6.39 (12.6) 3.68 (5.41) 0.014
ESR 16.3 (21.8) 14.7 (19.8) 0.752
Hgb 104 (45.7) 114 (95.3) 0.190
MorningS 7.39 (14.5) 6.78 (12.0) 0.666
Tender 3.12 (5.67) 3.80 (7.74) 0.280
Swollen 0.63 (2.11) 0.35 (1.21) 0.043
Gender: 0.581
female 284 (69.1%) 132 (71.7%)
male 127 (30.9%) 52 (28.3%)
age_years 55.9 (12.6) 54.3 (13.8) 0.168
age_Diagnosis 10.5 (7.44) 10.5 (8.19) 0.992
HAQ2 0.94 (0.75) 0.96 (0.81) 0.851

Cross Table between Biologics and On Biologics Status

RIT ADA TOC ETA ABA INF TOF CER GOL
Combination 107 107 47 62 31 20 13 15 11
Monotherapy 53 15 43 23 18 8 11 11 2
RIT ADA TOC ETA ABA INF TOF CER GOL
Combination 17.922948 17.922948 7.872697 10.385260 5.192630 3.350084 2.177554 2.512563 1.8425461
Monotherapy 8.877722 2.512563 7.202680 3.852596 3.015075 1.340034 1.842546 1.842546 0.3350084