1.8 Smoking habits of UK residents

(a) What does each row if the data matrix represent?

Each row represents a case or observation.

(b) How may participants were included in the survey?

The survey included 1691 participants.

(c) Indicate if each variable in the study is numerical or categorical

1. sex - categorical
2. age - numerical (discrete), though if placed in bins could be categorical (ordinal)
3. marital - categorical
4. gross income - categorical (ordinal)
5. smoke - categorical
6. amtWeekdays - Numerical (discrete) 7. amtWeekdays - Numerical (discrete)

1.10 Smoking habits of UK residents

(a) Identify the population of interest and the sample in the study?

The population is children between 5 and 15. The sample is comprised of 160 male and female children between 5 and 15

(b) Commment on if the results can be generalized to the population and if the findings of the study can be used to establish causal relationships.

The difference in the study could be random fluctation or they could be statistically meaningful. Not enough information is provided to make this assessment. Even if an association or associations were determined to exist, this does not mean there is a causal relationship, though one could exist.

1.28 Reading the paper

(a) Based on the study, can we conclude that smoking causes dementia later in life? Explain your answer

No, association does not mean a causal relationship exists. Additionally, it might be the case that the onset of dementia increases with age. Also, its possible the the sampling utilized could have introduced bias. Finally, causation can only be infered from a random experimental study - which this was not.

(b) A friend of yours who read the article says, the study shows that sleep disorders lead to bullying in school children. Is this statement justified? If not, how best can describe the conclusion that can be drawn from the study.

No, this was an observational study and therefore no causal association cna be determined. Additionally, it’s not clear if sleep disorder or bullying is the explanatory or response.

1.36 Exercise and Mental Health

(a)What type of study is this

experiment.

(b) What are the treatment and control groups in the study.

Treatment = exercise | Control = no exercise

(c) Does this study make use of blocking?.

Yes, the study is blocking with age.

(d) Does this study make use of blinding?.

If subjects knew it was a study that looked at the impact of exercise on mental health and some subjects were told not to exercise I would say no, blinding was not used. Though its not totally clear from reading the question.

(e) Comment on whether the results of the study can be used to estabish a causal relationship between exercise and mental health, and indicate whether or not the conclusions can be generalized to the population.

The study was an experiment and was random, so the study could establish a causal relationship and can be generalized to the population.

(f) Suppose you are given the task of determining if this study should get funding. Would you have any reservations about the study proposal?

No, the study appears to be designed well. It has a control group, its been randomized, there is replication and blocking.

1.48 Stat Scores

(a) Create a boxplot of the distribution of theses scores of twenty introductory statistics students.

stat_scores <- data.frame("scores" =c(57,66,69,71,72,73,74,77,78,78,79,79,81,81,82,83,83,88,89,94))

summary(stat_scores)
##      scores     
##  Min.   :57.00  
##  1st Qu.:72.75  
##  Median :78.50  
##  Mean   :77.70  
##  3rd Qu.:82.25  
##  Max.   :94.00
boxplot(stat_scores$scores, ylab='Student Scores', main='Distribution of Student Scores')

fivenum(stat_scores$scores)
## [1] 57.0 72.5 78.5 82.5 94.0

Question - Why does the summary command indicate that the 1st quartile is 72.75 and the fivenum indicates 72.5?

1.50 Mix and Match - Describe the distribution in the histograms below and match them to the box plots.

(a) Histogram a approximates a normal distribution and is fairly symetric and unimodal. It has a mean and median close to 60 and has some outliers. It matches to boxplot = 2

(b) Histogram, b appears to be multi-modal and without left or right tails. Histogram b matches to boxplot = 3

(c) Histogram c is right skewed (long right tail)and unimodal. It matches to boxplot = 1.

1.56 For each of the following state whether you expect the distribution to be symetric, right skewed, or left skewed. Also state if the mean or median would be the best representation of a typical observation in the data and whether the variability of the observations would be best represented by the standard deviation or IQR

(a) The distribution appears to be right skewed owing to the outlier homes with values over $6,000,000. This skew would make the median more representative than the mean. The large number of outliers, however, make the standard deviation more representative of the variability because IQR ignores outliers.

(b) This distribution appears to be more symetetric. Accordingly both median and mean should be close to one another and representive of typical observation. The lack of may outliers would make the IQR more representative of the variability.

(c) This distribution would be right skewed. Median and IQR since the number of outliers is small (only a few drink excessively)

(d) This is also right skewed. Median and standard deviation (sincer there would be more outliers)

1.70 Heart Transplants

library(openintro);data("heartTr")
## Please visit openintro.org for free statistics materials
## 
## Attaching package: 'openintro'
## The following objects are masked from 'package:datasets':
## 
##     cars, trees
heartTr
##      id acceptyear age survived survtime prior transplant wait
## 1    15         68  53     dead        1    no    control   NA
## 2    43         70  43     dead        2    no    control   NA
## 3    61         71  52     dead        2    no    control   NA
## 4    75         72  52     dead        2    no    control   NA
## 5     6         68  54     dead        3    no    control   NA
## 6    42         70  36     dead        3    no    control   NA
## 7    54         71  47     dead        3    no    control   NA
## 8    38         70  41     dead        5    no  treatment    5
## 9    85         73  47     dead        5    no    control   NA
## 10    2         68  51     dead        6    no    control   NA
## 11  103         67  39     dead        6    no    control   NA
## 12   12         68  53     dead        8    no    control   NA
## 13   48         71  56     dead        9    no    control   NA
## 14  102         74  40    alive       11    no    control   NA
## 15   35         70  43     dead       12    no    control   NA
## 16   95         73  40     dead       16    no  treatment    2
## 17   31         69  54     dead       16    no    control   NA
## 18    3         68  54     dead       16    no  treatment    1
## 19   74         72  29     dead       17    no  treatment    5
## 20    5         68  20     dead       18    no    control   NA
## 21   77         72  41     dead       21    no    control   NA
## 22   99         73  49     dead       21    no    control   NA
## 23   20         69  55     dead       28    no  treatment    1
## 24   70         72  52     dead       30    no  treatment    5
## 25  101         74  49    alive       31    no    control   NA
## 26   66         72  53     dead       32    no    control   NA
## 27   29         69  50     dead       35    no    control   NA
## 28   17         68  20     dead       36    no    control   NA
## 29   19         68  59     dead       37    no    control   NA
## 30    4         68  40     dead       39    no  treatment   36
## 31  100         74  35    alive       39   yes  treatment   38
## 32    8         68  45     dead       40    no    control   NA
## 33   44         70  42     dead       40    no    control   NA
## 34   16         68  56     dead       43    no  treatment   20
## 35   45         71  36     dead       45    no  treatment    1
## 36    1         67  30     dead       50    no    control   NA
## 37   22         69  42     dead       51    no  treatment   12
## 38   39         70  50     dead       53    no  treatment    2
## 39   10         68  42     dead       58    no  treatment   12
## 40   35         71  52     dead       61    no  treatment   10
## 41   37         70  61     dead       66    no  treatment   19
## 42   68         72  45     dead       68    no  treatment    3
## 43   60         71  49     dead       68    no  treatment    3
## 44   62         71  39     dead       69    no    control   NA
## 45   28         69  53     dead       72    no  treatment   71
## 46   47         71  47     dead       72    no  treatment   21
## 47   32         69  64     dead       77    no  treatment   17
## 48   65         72  51     dead       78    no  treatment   12
## 49   83         73  53     dead       80    no  treatment   32
## 50   13         68  54     dead       81    no  treatment   17
## 51    9         68  47     dead       85    no    control   NA
## 52   73         72  56     dead       90    no  treatment   27
## 53   79         72  53     dead       96    no  treatment   67
## 54   36         70  48     dead      100    no  treatment   46
## 55   32         71  41     dead      102    no    control   NA
## 56   98         73  28    alive      109    no  treatment   96
## 57   87         73  46     dead      110    no  treatment   60
## 58   97         73  23    alive      131    no  treatment   21
## 59   37         71  41     dead      149    no    control   NA
## 60   11         68  47     dead      153    no  treatment   26
## 61   94         73  43     dead      165   yes  treatment    4
## 62   96         73  26    alive      180    no  treatment   13
## 63   90         73  52     dead      186   yes  treatment  160
## 64   53         71  47     dead      188    no  treatment   41
## 65   89         73  51     dead      207    no  treatment  139
## 66   24         69  51     dead      219    no  treatment   83
## 67   27         69   8     dead      263    no    control   NA
## 68   93         73  47    alive      265    no  treatment   28
## 69   51         71  48     dead      285    no  treatment   32
## 70   67         73  19     dead      285    no  treatment   57
## 71   16         68  49     dead      308    no  treatment   28
## 72   84         73  42     dead      334    no  treatment   37
## 73   91         73  47     dead      340    no    control   NA
## 74   92         73  44    alive      340    no  treatment  310
## 75   58         71  47     dead      342   yes  treatment   21
## 76   88         73  54    alive      370    no  treatment   31
## 77   86         73  48    alive      397    no  treatment    8
## 78   82         71  29    alive      427    no    control   NA
## 79   81         73  52    alive      445    no  treatment    6
## 80   80         72  46    alive      482   yes  treatment   26
## 81   78         72  48    alive      515    no  treatment  210
## 82   76         72  52    alive      545   yes  treatment   46
## 83   64         72  48     dead      583   yes  treatment   32
## 84   72         72  26    alive      596    no  treatment    4
## 85   71         72  47    alive      630    no  treatment   31
## 86   69         72  47    alive      670    no  treatment   10
## 87    7         68  50     dead      675    no  treatment   51
## 88   23         69  58     dead      733    no  treatment    3
## 89   63         71  32    alive      841    no  treatment   27
## 90   30         69  44     dead      852    no  treatment   16
## 91   59         71  41    alive      915    no  treatment   78
## 92   56         71  38    alive      941    no  treatment   67
## 93   50         71  45     dead      979   yes  treatment   83
## 94   46         71  48     dead      995   yes  treatment    2
## 95   21         69  43     dead     1032    no  treatment    8
## 96   49         71  36    alive     1141   yes  treatment   36
## 97   41         70  45    alive     1321   yes  treatment   58
## 98   14         68  53     dead     1386    no  treatment   37
## 99   26         69  30    alive     1400    no    control   NA
## 100  40         70  48    alive     1407   yes  treatment   41
## 101  34         69  40    alive     1571    no  treatment   23
## 102  33         69  48    alive     1586    no  treatment   51
## 103  25         69  33    alive     1799    no  treatment   25
str(heartTr)
## 'data.frame':    103 obs. of  8 variables:
##  $ id        : int  15 43 61 75 6 42 54 38 85 2 ...
##  $ acceptyear: int  68 70 71 72 68 70 71 70 73 68 ...
##  $ age       : int  53 43 52 52 54 36 47 41 47 51 ...
##  $ survived  : Factor w/ 2 levels "alive","dead": 2 2 2 2 2 2 2 2 2 2 ...
##  $ survtime  : int  1 2 2 2 3 3 3 5 5 6 ...
##  $ prior     : Factor w/ 2 levels "no","yes": 1 1 1 1 1 1 1 1 1 1 ...
##  $ transplant: Factor w/ 2 levels "control","treatment": 1 1 1 1 1 1 1 2 1 1 ...
##  $ wait      : int  NA NA NA NA NA NA NA 5 NA NA ...
levels(heartTr$transplant)
## [1] "control"   "treatment"
levels(heartTr$survived)
## [1] "alive" "dead"

(a) Based in the mosaic plot, is survival independent of whether or not the patient got a transplant?

No, based upon the mosaic plot survival does not appear to independent of whether the patient got a transplat. The mosaic plot show a higher survival rate for the Treatment group vs the Control group.

(b)What do the boxplots below suggest about the efficacy of the heart transplant treatment?

The box plot suggest that the transplant has a high efficacy rate. In the Control most of the patients died before 200 days. In the Treatment group the median survival days was higher than the Control and Treatment group member had a substantially better chance to survive more than 500 days

(c) What proportion of patients in the treatment group and what proportion of patients in the control group died?

treatment_dead_prop <- nrow(subset(heartTr, heartTr$transplant=="treatment" & heartTr$survived=="dead")) / nrow(subset(heartTr, heartTr$transplant=="treatment"))

treatment_dead_prop
## [1] 0.6521739
control_dead_prop <- nrow(subset(heartTr, heartTr$transplant=="control" & heartTr$survived=="dead")) / nrow(subset(heartTr, heartTr$transplant=="control"))
 
control_dead_prop
## [1] 0.8823529

(d) One approach for investigating whether or not the treatment is effective is to use a randomization technique.

i. What are the claims being tested?

Null Hypoth - current state transplants have no bearing on lifespan.

Alternative - heart transplats increase lifespan.

ii. The paragraph below describes the set up for such approach, if we were to do it without using statistical software. Fill in the blanks with a number or phrase, whichever is appropriate.

We write alive on 28 cards representing patients who were alive at the end of the study, and dead on 75 cards representing patients who were not. Then, we shuffle these cards and split them into two groups: one group of size 69 representing treatment, and another group of size 34 representing control. We calculate the difference between the proportion of dead cards in the treatment and control groups (treatment - control) and record this value. We repeat this 100 times to build a distribution centered at -0.230179. If this fraction is low, we conclude that it is unlikely to have observed such an outcome by chance and that the null hypothesis should be rejected in favor of the alternative.

iii. What do the simulation results shown below suggest about the effectiveness of the transplant program?

Per item (ii) above, the fraction was low. Only 2% of the simulation results were in the range of -.230179. Therefore, we would conclude its not a random event and transplants do increase lifespan.