1.Description

2. Height

Height_Wood - INTERVAL significant gene:

IV Gene Presso.b Presso.se Presso.p
64 14 ASIP, AGTI, AGTIL, ASP -0.0525823 0.0052562 0.0000016
66 10 ASPN, PLAP1, SLRR1C, UNQ215, PRO241 0.0507841 0.0024229 0.0000000
108 16 C1QTNF5, CTRP5, UNQ303, PRO344 -0.1359245 0.0061050 0.0000000
112 33 C4A, CO4, CPAMD2, C4B, CPAMD3;, C4B_2 -0.0533380 0.0029739 0.0000000
173 29 CD96 -0.0673960 0.0026591 0.0000000
190 10 CFB, BF, BFD 0.0140583 0.0010780 0.0000036
283 26 DEFB119, DEFB120, DEFB19, DEFB20, UNQ2449, PRO5729 -0.0569561 0.0043716 0.0000000
457 36 GRIA4, GLUR4 -0.0508216 0.0021849 0.0000000
489 18 HLA-DQA2, HLA-DXA -0.0594165 0.0078578 0.0000192
546 14 IL21 -0.0757810 0.0082321 0.0000034
576 12 JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2 -0.0292033 0.0018751 0.0000011
593 17 KIR2DS2, CD158J, NKAT5 0.0955146 0.0045906 0.0000000
617 22 LCT, LPH 0.0238408 0.0014351 0.0000000
639 10 LRPAP1, A2MRAP -0.0307323 0.0036628 0.0000151
640 10 LRPAP1, A2MRAP -0.0347050 0.0040139 0.0000118
684 40 MICB, PERB11.2 -0.0335453 0.0020493 0.0000000
784 10 PAM 0.0196422 0.0037870 0.0008359
801 34 PDE4D, DPDE3 -0.0437420 0.0030413 0.0000000
867 23 PRSS3, PRSS4, TRY3, TRY4 0.0402373 0.0070988 0.0000349
894 22 RACGAP1, KIAA1478, MGCRACGAP 0.0531465 0.0065270 0.0000002

Height_Woods Overlap of INTERVAL to GTEx, Cage, Gevidas

Each gene as exposure data to each trait as outcome has little instrumental variables, as you can see the column ‘IV>5’. So here we take wald test if there are only 1 IV, inverse variance weighted test if there are only 2 or 3 IVs, Presso for more then 3 IVs for gene expression data here.

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 708 9 3 ACP2, MAPKAPK3, MSRA 37 PAM
Gevadis 91 0 0 13 MICB MICB
Prostate 41 0 0 6
Nerve_Tibial 354 1 0 28 C4A, HLA-DQA2 C4A, HLA-DQA2
Minor_Salivary_Gland 23 0 0 6
Brain_Nucleus_accumbens_basal_ganglia 55 0 0 6
Small_Intestine_Terminal_Ileum 31 0 0 4 C4A C4A
Pituitary 88 0 0 6 C4A C4A, LRPAP1
Adipose_Subcutaneous 272 1 1 C4A C4A 22 C4A C4A
Skin_Sun_Exposed_Lower_leg 304 0 0 22 C4A, C4B C4A, C4B, LRPAP1, MICB
Esophagus_Mucosa 263 0 0 32 C4A, C4B C4A, C4B
Brain_Hypothalamus 33 0 0 4
Breast_Mammary_Tissue 101 0 0 13 C4A C4A
Brain_Anterior_cingulate_cortex_BA24 33 0 0 8 C4A C4A
Adrenal_Gland 112 0 0 10 C4A, C4B C4A, C4B
Artery_Aorta 191 0 0 23 C4A, MICB C4A, MICB
Brain_Substantia_nigra 27 0 0 6
Cells_EBV-transformed_lymphocytes 51 1 1 C4A C4A 6 C4A C4A
Pancreas 151 0 0 17 C4A C4A, GRIA4
Brain_Cortex 72 0 0 8 C4A C4A, LRPAP1
Brain_Hippocampus 45 0 0 5
Brain_Frontal_Cortex_BA9 47 0 0 7 C4A C4A
Artery_Tibial 277 0 0 23 C4A, MICB C4A, MICB
Uterus 25 0 0 5
Adipose_Visceral_Omentum 174 0 0 17 C4A C4A
Artery_Coronary 50 0 0 7
Colon_Transverse 122 0 0 11 C4A C4A
Stomach 98 0 0 17 C4A C4A
Vagina 22 0 0 4 HLA-DQA2
Heart_Atrial_Appendage 155 1 1 C4A C4A 18 C4A
Brain_Putamen_basal_ganglia 52 0 0 4
Brain_Spinal_cord_cervical_c-1 41 0 0 4
Skin_Not_Sun_Exposed_Suprapubic 210 1 1 C4A C4A 20 ASIP, C4B, MICB ASIP, C4A, C4B, LRPAP1, MICB
Testis 201 0 0 14 C4A C4A
Ovary 45 0 0 11 C4A C4A
Heart_Left_Ventricle 146 1 1 C4A C4A 14 HLA-DQA2 C4A, HLA-DQA2
Cells_Transformed_fibroblasts 254 0 0 29 C4A, C4B C4A, C4B, LRPAP1
Brain_Cerebellar_Hemisphere 102 0 0 10 C4A, MICB C4A, LRPAP1, MICB, PAM
Esophagus_Muscularis 236 0 0 20 C4A C4A
Spleen 113 0 0 10 C4A C4A
Brain_Caudate_basal_ganglia 77 0 0 6 C4A C4A
Muscle_Skeletal 234 0 0 28 C4A C4A
Brain_Cerebellum 152 0 0 19 C4A, MICB C4A, LRPAP1, MICB, PAM
Esophagus_Gastroesophageal_Junction 114 0 0 14 C4A C4A
Lung 243 1 1 C4A C4A 23 C4B C4A, C4B
Thyroid 307 0 0 28 C4A C4A
Liver 72 0 0 10 C4A C4A
Brain_Amygdala 23 0 0 3 C4A C4A
Colon_Sigmoid 110 0 0 12 C4A C4A
Whole_Blood 197 1 1 C4A C4A 18 C4A, C4B, HLA-DQA2 C4A, C4B, HLA-DQA2

Height_UKBB - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to Height_ukbb : 324 
## ## Significant by Presso after bonferroni correction: 96
IV Gene Presso.b Presso.se Presso.p
11 11 ACP1 0.0853030 0.0110947 0.0000304
28 31 ADH1B, ADH2 -0.1016654 0.0230741 0.0001403
37 19 AGRP, AGRT, ART -0.7075295 0.0100163 0.0000000
76 13 AP4M1, MUARP2 0.6353577 0.0342015 0.0000083
96 18 APOL1, APOL 0.0650684 0.0088435 0.0000055
133 61 ASIP, AGTI, AGTIL, ASP -0.2919370 0.0088443 0.0000000
137 20 ASPN, PLAP1, SLRR1C, UNQ215, PRO241 0.2607313 0.0101087 0.0000000
214 19 C1QTNF1, CTRP1, UNQ310, PRO353 -0.1357619 0.0221609 0.0000745
216 33 C1QTNF5, CTRP5, UNQ303, PRO344 -0.7693720 0.0214456 0.0000000
221 141 C4A, CO4, CPAMD2, C4B, CPAMD3;, C4B_2 -0.4045397 0.0196537 0.0000000
273 13 CCL19, ELC, MIP3B, SCYA19 -0.3000614 0.0288238 0.0000002
312 20 CD34 0.2863126 0.0123350 0.0000000
318 10 CD55, CR, DAF 0.1267614 0.0146543 0.0000118
326 64 CD96 -0.6852881 0.0170240 0.0000000
420 22 CNTN2, AXT, TAG1, TAX1 0.0470309 0.0092250 0.0000475
438 13 COLGALT1, GLT25D1, PSEC0241 0.1036741 0.0142373 0.0000097
449 26 CPNE1, CPN1 -0.3942885 0.0120922 0.0000005
455 45 CREB3L4, AIBZIP, CREB4, JAL -0.3894651 0.0247741 0.0000000
458 21 CRELD1, CIRRIN, UNQ188, PRO214 -0.0947098 0.0117398 0.0000001
488 27 CTRB1, CTRB 0.0915132 0.0159463 0.0000056
495 29 CTSS 0.1110270 0.0112526 0.0000000
537 76 DEFB119, DEFB120, DEFB19, DEFB20, UNQ2449, PRO5729 -0.6534176 0.0272670 0.0000000
566 21 DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537, PRO1080 -0.7057006 0.0395346 0.0000000
576 16 DOCK9, KIAA1058, ZIZ1 -0.2588052 0.0299399 0.0000554
631 34 EMC4, TMEM85, HSPC184, PIG17 -0.0637861 0.0146227 0.0001323
646 14 ENTPD5, CD39L4, PCPH -0.0658643 0.0083148 0.0000072
701 24 FAM177A1, C14orf24 0.1132297 0.0219324 0.0000554
765 29 FTL, FTH1, FTH, FTHL6, OK, SW-cl.84, PIG15 0.1998263 0.0219761 0.0000001
770 11 FUT8 -0.0784870 0.0114992 0.0000459
783 25 GALNT1 1.1575076 0.0334019 0.0000000
829 13 GP1BA -0.4734893 0.0281666 0.0000000
845 15 GPX7, GPX6, UNQ469, PRO828 0.2832868 0.0280564 0.0000003
853 107 GRIA4, GLUR4 -0.4934953 0.0146159 0.0000000
870 17 GZMA, CTLA3, HFSP -0.9999864 0.0478061 0.0000000
878 11 HAAO 0.0981061 0.0080136 0.0000018
883 14 HBEGF, DTR, DTS, HEGFL 0.5074406 0.0397473 0.0000002
889 12 HDHD2 0.1247473 0.0177295 0.0000217
898 15 HINT1, HINT, PKCI1, PRKCNH1 -0.6312086 0.0494003 0.0000000
905 47 HLA-DQA2, HLA-DXA -0.6931452 0.0441885 0.0000000
918 62 HP 0.1068693 0.0120975 0.0000000
992 11 IL18R1, IL1RRP -0.0836007 0.0116718 0.0000306
993 20 IL18R1, IL1RRP -0.0561720 0.0096492 0.0000131
997 18 IL1R2, IL1RB -0.1608579 0.0172547 0.0000000
1004 46 IL21 -0.3974309 0.0419819 0.0000000
1045 27 ISG15, G1P2, UCRP 1.2162112 0.0385695 0.0000000
1054 24 ITIH1, IGHEP1 0.2173910 0.0111957 0.0000000
1062 19 JAK2 0.1258182 0.0227856 0.0000373
1063 31 JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2 -0.1955496 0.0155334 0.0000000
1077 11 KDR, FLK1, VEGFR2 0.2380059 0.0246051 0.0000266
1090 42 KIR2DS2, CD158J, NKAT5 0.6924007 0.0282779 0.0000000
1113 10 KPNA2, RCH1, SRP1 -0.2502898 0.0208409 0.0000202
1177 83 LRPAP1, A2MRAP -0.2758180 0.0144683 0.0000000
1178 69 LRPAP1, A2MRAP -0.3138183 0.0180123 0.0000000
1213 16 MANBA, MANB1 0.0822194 0.0132485 0.0000319
1214 19 MANEA -0.0493708 0.0070480 0.0000015
1256 127 MICB, PERB11.2 -0.3030967 0.0115782 0.0000000
1265 18 MMP12, HME -0.0528137 0.0107447 0.0001309
1270 78 MMP8, CLG1 -0.0881189 0.0148705 0.0000001
1318 35 NAALAD2 -0.5757001 0.0312264 0.0000000
1325 15 NAT1, AAC1 0.4319155 0.0272441 0.0000000
1336 19 NCR3, 1C7, LY117 0.2991087 0.0390719 0.0000015
1354 16 NFASC, KIAA0756 0.0678419 0.0108019 0.0000147
1366 12 NMES1, C15orf48 -0.4969976 0.0247819 0.0000000
1383 26 NQO1, DIA4, NMOR1 0.1859149 0.0111097 0.0000000
1401 17 NSF -1.2668920 0.0633915 0.0000000
1448 44 PAM 0.1758587 0.0076819 0.0000000
1456 10 PATE4 -0.1694572 0.0232990 0.0000470
1472 16 PCSK1, NEC1 -0.1102017 0.0100940 0.0000000
1480 117 PDE4D, DPDE3 -0.4493851 0.0148662 0.0000000
1488 29 PDGFRL, PRLTS 0.0803869 0.0153942 0.0000485
1535 21 PLG 0.1351455 0.0150482 0.0000000
1547 25 POFUT1, FUT12, KIAA0180 -0.1617250 0.0322023 0.0000499
1548 13 POFUT2, C21orf80, FUT13, KIAA0958 -0.1270411 0.0195635 0.0001123
1552 12 POMC 0.1139919 0.0140345 0.0000057
1573 84 PRDM1, BLIMP1 -0.0605448 0.0133310 0.0000275
1576 24 PRELP, SLRR2A -0.0917562 0.0127404 0.0000006
1599 73 PRSS3, PRSS4, TRY3, TRY4 0.3469734 0.0285418 0.0000000
1617 13 PTH2, TIP39, TIPF39 -1.0178344 0.0709204 0.0000000
1652 75 RACGAP1, KIAA1478, MGCRACGAP 0.4972673 0.0247099 0.0000000
1656 26 RAD51D, RAD51L3 -0.3276186 0.0164907 0.0000000
1661 33 RARRES1, PEIG1, TIG1 -0.0781926 0.0043099 0.0000000
1787 19 SEMA4D, C9orf164, CD100, SEMAJ 0.0310105 0.0064482 0.0001406
1808 19 SERPING1, C1IN, C1NH 0.0842552 0.0127689 0.0000034
1823 39 SIGIRR, UNQ301, PRO342 -0.1849882 0.0127886 0.0000000
1838 10 SIRT5, SIR2L5 0.6102202 0.0542157 0.0000098
1844 11 SLC14A2, HUT2, UT2 0.0558934 0.0077696 0.0000512
1909 52 ST3GAL6, SIAT10 -0.0820813 0.0085128 0.0000000
1992 18 THSD1, TMTSP, UNQ3010, PRO9769 0.2846264 0.0166113 0.0000000
2050 110 TNXB, HXBL, TNX, TNXB1, TNXB2, XB 0.0718068 0.0057539 0.0000000
2062 12 TPST1 -0.4700928 0.0074356 0.0000000
2068 10 TREML2, C6orf76, TLT2, UNQ6268, PRO20473 -0.0767804 0.0100803 0.0000327
2089 13 UAP1, SPAG2 1.2720127 0.0839182 0.0000000
2116 56 USP25, USP21 -0.2042950 0.0075630 0.0000000
2121 14 VCAM1 -0.4487614 0.0154536 0.0000000
2130 19 VPS29, DC15, DC7, MDS007 0.0696404 0.0089178 0.0000003
2139 28 VTN 0.0526054 0.0107138 0.0000522

Overlaps of Height_woods and Height_ukbb

##  [1] "ASIP, AGTI, AGTIL, ASP"                            
##  [2] "ASPN, PLAP1, SLRR1C, UNQ215, PRO241"               
##  [3] "C1QTNF5, CTRP5, UNQ303, PRO344"                    
##  [4] "C4A, CO4, CPAMD2, C4B, CPAMD3;, C4B_2"             
##  [5] "CD96"                                              
##  [6] "DEFB119, DEFB120, DEFB19, DEFB20, UNQ2449, PRO5729"
##  [7] "GRIA4, GLUR4"                                      
##  [8] "HLA-DQA2, HLA-DXA"                                 
##  [9] "IL21"                                              
## [10] "JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2"        
## [11] "KIR2DS2, CD158J, NKAT5"                            
## [12] "LRPAP1, A2MRAP"                                    
## [13] "MICB, PERB11.2"                                    
## [14] "PAM"                                               
## [15] "PDE4D, DPDE3"                                      
## [16] "PRSS3, PRSS4, TRY3, TRY4"                          
## [17] "RACGAP1, KIAA1478, MGCRACGAP"

Height_Woods Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1350 155 9 ABHD12, ACP2, ARFGAP2, HINT1, IER3, LRRC37A2, MSRA, TPST1, VARS2 HINT1, TPST1 102 ACP1, AGRP, FUT8, HINT1, NCR3, NQO1, TPST1 ACP1, AGRP, CD55, CPNE1, CRELD1, FAM177A1, FUT8, GPX6, GPX7, HBEGF, HDHD2, HINT1, IL18R1, IL1R2, MANBA, NAT1, NCR3, NQO1, PAM, TPST1, VPS29
Gevadis 232 1 1 LRRC37A2 39 CPNE1, MICB, POMC CPNE1, CTSS, HLA-DQA2, MICB, POMC
Prostate 98 1 1 LRRC37A2 20 CPNE1, CRELD1 CPNE1, CRELD1, GPX7
Nerve_Tibial 818 12 4 C4A, FOLH1, LRRC37A2, MICB C4A, MICB 117 C4A, CRELD1, CTSS, DOCK9, HDHD2, MICB, TPST1 ADH1B, C4A, CREB3L4, CRELD1, CTSS, DOCK9, GPX7, HAAO, HDHD2, HP, IL18R1, JAK2, MANEA, MICB, NQO1, PCSK1, POFUT2, SEMA4D, TPST1, VPS29
Minor_Salivary_Gland 63 0 0 14 CPNE1 CPNE1, CTSS
Brain_Nucleus_accumbens_basal_ganglia 159 1 1 LRRC37A2 20 CPNE1, HAAO CPNE1, HAAO
Small_Intestine_Terminal_Ileum 108 2 2 C4A, LRRC37A2 C4A 18 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, GPX7, HLA-DQA2
Pituitary 212 1 1 C4A C4A 36 C4A, CPNE1, HAAO, HLA-DQA2 C4A, CPNE1, CTSS, HAAO, HLA-DQA2, LRPAP1
Adipose_Subcutaneous 617 11 4 C4A, LRRC37A2, MICB, TPST1 C4A, MICB, TPST1 77 C4A, CRELD1, FAM177A1, GALNT1, HINT1, MICB ADH1B, C4A, CREB3L4, CRELD1, CTSS, ENTPD5, FAM177A1, GALNT1, GPX7, HAAO, HDHD2, HINT1, ISG15, MICB, PDGFRL, SIRT5, TPST1
Skin_Sun_Exposed_Lower_leg 704 14 7 ASIP, ASL, C4A, C4B, FOLH1, HLA-DMA, LRRC37A2 ASIP, C4A, C4B 92 ASIP, C4A, C4B, CRELD1, FAM177A1, PAM, RARRES1, ST3GAL6 ASIP, C4A, C4B, CD55, CRELD1, CTSS, DOCK9, FAM177A1, HAAO, IL1R2, LRPAP1, MANEA, MICB, PAM, RARRES1, ST3GAL6, VPS29
Esophagus_Mucosa 641 10 6 ACP2, C4A, CROT, LRRC37A2, P4HA2, TPST1 C4A, TPST1 83 C4A, CPNE1, CRELD1, HLA-DQA2, NSF C4A, C4B, CD55, CPNE1, CRELD1, DOCK9, GPX7, HAAO, HLA-DQA2, NSF, ST3GAL6, TPST1, VPS29
Brain_Hypothalamus 92 1 1 LRRC37A2 14 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HAAO, HLA-DQA2
Breast_Mammary_Tissue 304 2 2 C4A, LRRC37A2 C4A 43 C4A, CPNE1, CRELD1, GALNT1 C4A, CPNE1, CRELD1, CTSS, GALNT1, GPX7, HAAO, HDHD2, MANEA, MICB, TPST1
Brain_Anterior_cingulate_cortex_BA24 119 0 0 18 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HLA-DQA2, SIRT5
Adrenal_Gland 282 2 2 C4A, LRRC37A2 C4A 35 C4A, C4B, CD55, CPNE1, CRELD1, HLA-DQA2, TNXB C4A, C4B, CD55, CPNE1, CRELD1, GPX7, HLA-DQA2, MANEA, ST3GAL6, TNXB
Artery_Aorta 490 5 3 C4A, FOLH1, MICB C4A, MICB 67 C4A, CRELD1, CTSS, HLA-DQA2, ST3GAL6 C4A, CPNE1, CREB3L4, CRELD1, CTSS, GPX7, HLA-DQA2, MANEA, MICB, ST3GAL6
Brain_Substantia_nigra 64 0 0 10 CPNE1 CPNE1
Cells_EBV-transformed_lymphocytes 133 2 2 C4A, LRRC37A2 C4A 20 C4A C4A, CPNE1, HDHD2
Pancreas 382 4 4 C4A, HLA-DMA, LRRC37A2, VARS2 C4A 48 C4A, CPNE1, HAAO, HLA-DQA2 C4A, CPNE1, CTRB1, GPX7, HAAO, HLA-DQA2, MANEA, ST3GAL6
Brain_Cortex 209 1 1 LRRC37A2 35 C4A, C4B, CPNE1, HLA-DQA2 C4A, C4B, CPNE1, HLA-DQA2, LRPAP1, SIRT5
Brain_Hippocampus 108 0 0 16 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HLA-DQA2
Brain_Frontal_Cortex_BA9 151 0 0 21 C4A, CPNE1 C4A, CPNE1, HLA-DQA2, RARRES1
Artery_Tibial 672 10 6 ABHD12, C4A, CTSS, FOLH1, P4HA2, SERPINC1 C4A, CTSS 92 ACP1, CD55, CRELD1, DOCK9, ISG15, PCSK1 ACP1, ADH1B, AP4M1, C4A, C4B, CD55, CPNE1, CRELD1, CTSS, DOCK9, GPX7, HDHD2, ISG15, PCSK1, SEMA4D, ST3GAL6, VPS29
Uterus 70 0 0 12 CPNE1, CRELD1, HLA-DQA2 CPNE1, CRELD1, GPX7, HLA-DQA2
Adipose_Visceral_Omentum 426 7 3 C4A, LRRC37A2, MICB C4A, MICB 53 C4A, CRELD1, GALNT1, HLA-DQA2 C4A, CD55, CPNE1, CRELD1, CTSS, GALNT1, GPX7, HAAO, HDHD2, HLA-DQA2, MICB, TPST1, VPS29
Artery_Coronary 159 2 2 C4A, LRRC37A2 C4A 31 C4A, CPNE1, CRELD1, HLA-DQA2, MICB C4A, CPNE1, CRELD1, GPX7, HLA-DQA2, MICB
Colon_Transverse 313 3 2 C4A, LRRC37A2 C4A 42 C4A, CPNE1, CRELD1, CTSS C4A, CPNE1, CRELD1, CTSS, GPX7, NQO1, VPS29
Stomach 248 3 3 C4A, CSDC2, LRRC37A2 C4A 33 C4A, CPNE1 C4A, CPNE1, GPX7, HLA-DQA2, ST3GAL6
Vagina 60 1 1 LRRC37A2 10 CPNE1, CRELD1, GPX7, HLA-DQA2 CPNE1, CRELD1, GPX7, HLA-DQA2
Heart_Atrial_Appendage 398 3 3 C4A, CPNE1, FOLH1 C4A, CPNE1 60 ACP1, C4A, CRELD1, HAAO, PCSK1, POMC ACP1, C4A, CPNE1, CRELD1, EMC4, FAM177A1, GPX7, HAAO, HLA-DQA2, PCSK1, PDGFRL, POMC, SIRT5, TPST1, VPS29
Brain_Putamen_basal_ganglia 139 0 0 20 CPNE1, HLA-DQA2 CPNE1, HLA-DQA2
Brain_Spinal_cord_cervical_c-1 89 1 1 LRRC37A2 14 CPNE1, NAALAD2 CPNE1, HAAO, NAALAD2
Skin_Not_Sun_Exposed_Suprapubic 530 9 8 ASIP, ASL, C4A, C4B, CPNE1, CROT, FOLH1, LRRC37A2 ASIP, C4A, C4B, CPNE1 72 C4A, C4B, CRELD1, RARRES1, ST3GAL6 ASIP, C4A, C4B, CD55, CPNE1, CRELD1, EMC4, HAAO, HLA-DQA2, IL1R2, LRPAP1, RARRES1, ST3GAL6
Testis 504 4 1 C4A C4A 69 C4A, C4B, CPN1, CPNE1, CRELD1, HLA-DQA2, NQO1 C4A, C4B, CPN1, CPNE1, CRELD1, GPX7, HAAO, HLA-DQA2, NQO1
Ovary 124 1 1 LRRC37A2 27 C4A, CPNE1, CRELD1, HLA-DQA2 C4A, CPNE1, CRELD1, GPX7, HLA-DQA2
Heart_Left_Ventricle 377 8 5 C4A, CPNE1, LRRC37A2, MICB, TPST1 C4A, CPNE1, MICB, TPST1 64 C4A, CRELD1, HINT1, MICB, NSF C4A, CPNE1, CRELD1, FAM177A1, GPX7, HINT1, MICB, NSF, TPST1
Cells_Transformed_fibroblasts 598 4 3 C4A, C4B, LRRC37A2 C4A, C4B 79 C4A, C4B, CPNE1, CRELD1, ST3GAL6 ADH1B, C4A, C4B, CPNE1, CREB3L4, CRELD1, GPX7, HDHD2, LRPAP1, MANEA, POFUT2, SEMA4D, ST3GAL6, THSD1, USP25, VPS29
Brain_Cerebellar_Hemisphere 252 2 2 C4A, LRRC37A2 C4A 41 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HLA-DQA2, LRPAP1, MANEA, PAM
Esophagus_Muscularis 601 8 4 C4A, FOLH1, MICB, VARS2 C4A, MICB 74 C4A, CPNE1, CRELD1, POMC C4A, CPNE1, CREB3L4, CRELD1, CTSS, FAM177A1, GP1BA, GPX7, HAAO, HDHD2, HLA-DQA2, MICB, POMC, TPST1, VPS29
Spleen 251 3 2 C4A, LRRC37A2 C4A 35 C4A, CPNE1, CRELD1, DOCK9, HLA-DQA2, MICB, VPS29 C4A, CPNE1, CRELD1, DOCK9, GPX7, HLA-DQA2, MICB, VPS29
Brain_Caudate_basal_ganglia 206 1 1 C4A C4A 32 C4A, CPNE1, CTSS, HLA-DQA2 C4A, CPNE1, CTSS, HAAO, HLA-DQA2
Muscle_Skeletal 617 8 4 ARPC3, C4A, MAPKAPK3, TPST1 C4A, TPST1 83 C4A, CPNE1, HDHD2, NSF ACP1, C4A, CD55, CPNE1, CREB3L4, FAM177A1, HDHD2, IL18R1, MANEA, MICB, NQO1, NSF, ST3GAL6, TPST1, VPS29
Brain_Cerebellum 385 3 2 C4A, LRRC37A2 C4A 57 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HLA-DQA2, LRPAP1, MANEA, PAM, RARRES1
Esophagus_Gastroesophageal_Junction 298 2 2 C4A, LRRC37A2 C4A 37 C4A, CPNE1, CRELD1, HLA-DQA2 C4A, CPNE1, CRELD1, CTSS, GPX7, HLA-DQA2
Lung 592 7 4 ACP2, C4A, LRRC37A2, TPST1 C4A, TPST1 88 C4A, C4B, CPNE1, CRELD1, CTSS, FAM177A1, HDHD2, HLA-DQA2, TPST1 C4A, C4B, CPNE1, CREB3L4, CRELD1, CTSS, EMC4, FAM177A1, FUT8, HAAO, HDHD2, HLA-DQA2, SEMA4D, SIRT5, TPST1
Thyroid 756 14 4 C4A, MICB, P4HA2, SERPINC1 C4A, MICB 83 C4A, HAAO, MICB C4A, CD55, CPNE1, CREB3L4, GPX7, HAAO, HLA-DQA2, MICB, SEMA4D, ST3GAL6, TPST1, VPS29
Liver 164 2 2 C4A, HLA-DMA C4A 29 C4A, CPNE1 C4A, CPNE1, GPX7, HLA-DQA2
Brain_Amygdala 66 2 2 C4A, LRRC37A2 C4A 8 C4A, CPNE1, HLA-DQA2 C4A, CPNE1, HLA-DQA2
Colon_Sigmoid 302 3 2 C4A, LRRC37A2 C4A 45 C4A, CPNE1, CRELD1, HLA-DQA2 C4A, CPNE1, CREB3L4, CRELD1, CTSS, HAAO, HLA-DQA2
Whole_Blood 532 5 5 C4A, C4B, CPNE1, LRRC37A2, MICB C4A, C4B, CPNE1, MICB 71 C4A, C4B, CRELD1, HINT1, MICB C4A, C4B, CD55, CPNE1, CRELD1, FAM177A1, GPX7, HINT1, LRPAP1, MICB, PAM, VPS29

3. BMI

BMI_MEN - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to BMI_MEN : 22 
## ## Significant by Presso after bonferroni correction: 5
IV Gene Presso.b Presso.se Presso.p
66 10 ASPN, PLAP1, SLRR1C, UNQ215, PRO241 -0.0144072 0.0031697 0.0013953
578 11 JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2 0.0218822 0.0029526 0.0000229
620 21 LCT, LPH 0.0268072 0.0032970 0.0000001
731 11 NDUFS4 -0.0093656 0.0022771 0.0021008
992 10 SIGIRR, UNQ301, PRO342 0.0250127 0.0048944 0.0006360

BMI_MEN Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 721 12 0 3
Gevadis 92 0 0 0
Prostate 40 0 0 0
Nerve_Tibial 356 1 0 0
Minor_Salivary_Gland 22 0 0 1
Brain_Nucleus_accumbens_basal_ganglia 55 0 0 1
Small_Intestine_Terminal_Ileum 32 0 0 0
Pituitary 89 0 0 0
Adipose_Subcutaneous 272 0 0 0
Skin_Sun_Exposed_Lower_leg 302 0 0 0
Esophagus_Mucosa 263 0 0 0
Brain_Hypothalamus 31 0 0 1
Breast_Mammary_Tissue 102 0 0 1
Brain_Anterior_cingulate_cortex_BA24 34 0 0 0
Adrenal_Gland 112 0 0 2
Artery_Aorta 194 0 0 1
Brain_Substantia_nigra 25 0 0 1
Cells_EBV-transformed_lymphocytes 50 0 0 1
Pancreas 151 0 0 1
Brain_Cortex 72 0 0 1
Brain_Hippocampus 45 0 0 1
Brain_Frontal_Cortex_BA9 46 0 0 0
Artery_Tibial 277 0 0 0
Uterus 24 0 0 1
Adipose_Visceral_Omentum 177 0 0 2
Artery_Coronary 53 0 0 0
Colon_Transverse 122 0 0 1
Stomach 97 0 0 1
Vagina 21 0 0 0
Heart_Atrial_Appendage 156 0 0 0
Brain_Putamen_basal_ganglia 53 0 0 1
Brain_Spinal_cord_cervical_c-1 40 0 0 0
Skin_Not_Sun_Exposed_Suprapubic 213 0 0 1
Testis 204 0 0 0
Ovary 44 0 0 1
Heart_Left_Ventricle 147 0 0 0
Cells_Transformed_fibroblasts 259 0 0 0
Brain_Cerebellar_Hemisphere 103 0 0 1
Esophagus_Muscularis 239 0 0 1
Spleen 112 0 0 2
Brain_Caudate_basal_ganglia 76 0 0 1
Muscle_Skeletal 234 0 0 1
Brain_Cerebellum 151 0 0 1
Esophagus_Gastroesophageal_Junction 116 0 0 2
Lung 240 0 0 0
Thyroid 308 0 0 1
Liver 72 0 0 0
Brain_Amygdala 23 0 0 0
Colon_Sigmoid 117 0 0 1
Whole_Blood 195 0 0 3

BMI_WOMEN - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to BMI_WOMEN : 22 
## ## Significant by Presso after bonferroni correction: 9
IV Gene Presso.b Presso.se Presso.p
64 17 ASIP, AGTI, AGTIL, ASP -0.0318178 0.0020668 0.0000000
460 12 GRIA4, GLUR4 -0.0260399 0.0051677 0.0003786
578 11 JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2 0.0210848 0.0027257 0.0000158
620 21 LCT, LPH 0.0133769 0.0022805 0.0000097
687 12 MICB, PERB11.2 -0.0261753 0.0026737 0.0000009
806 13 PDE4D, DPDE3 -0.0293677 0.0043056 0.0000185
992 10 SIGIRR, UNQ301, PRO342 0.0226637 0.0042359 0.0004621
1050 14 STOM, BND7, EPB72 0.0272593 0.0054014 0.0002237
1096 12 TMPRSS11D, HAT 0.0221837 0.0046152 0.0005475

Overlaps of Height_woods and Height_ukbb

## [1] "JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2"
## [2] "LCT, LPH"                                  
## [3] "SIGIRR, UNQ301, PRO342"

BMI_WOMEN Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 723 12 3 MAPKAPK3, MSRA, VARS2 2
Gevadis 93 0 0 0 MICB
Prostate 40 0 0 0
Nerve_Tibial 356 1 1 CKAP2 0
Minor_Salivary_Gland 22 0 0 1
Brain_Nucleus_accumbens_basal_ganglia 55 0 0 0
Small_Intestine_Terminal_Ileum 32 0 0 0
Pituitary 89 0 0 0
Adipose_Subcutaneous 273 0 0 2
Skin_Sun_Exposed_Lower_leg 302 0 0 1
Esophagus_Mucosa 264 0 0 0
Brain_Hypothalamus 31 0 0 0
Breast_Mammary_Tissue 102 0 0 1
Brain_Anterior_cingulate_cortex_BA24 34 0 0 0
Adrenal_Gland 112 0 0 0
Artery_Aorta 194 0 0 0
Brain_Substantia_nigra 25 0 0 0
Cells_EBV-transformed_lymphocytes 50 0 0 0
Pancreas 151 0 0 0
Brain_Cortex 72 0 0 0
Brain_Hippocampus 45 0 0 0
Brain_Frontal_Cortex_BA9 46 0 0 0
Artery_Tibial 277 0 0 1
Uterus 25 0 0 0
Adipose_Visceral_Omentum 178 0 0 2
Artery_Coronary 53 0 0 0
Colon_Transverse 122 0 0 0
Stomach 97 0 0 0
Vagina 21 0 0 0
Heart_Atrial_Appendage 157 0 0 1
Brain_Putamen_basal_ganglia 53 0 0 0
Brain_Spinal_cord_cervical_c-1 40 0 0 0
Skin_Not_Sun_Exposed_Suprapubic 212 0 0 0 ASIP
Testis 204 0 0 0
Ovary 44 0 0 0
Heart_Left_Ventricle 148 0 0 0
Cells_Transformed_fibroblasts 259 0 0 0
Brain_Cerebellar_Hemisphere 103 0 0 0
Esophagus_Muscularis 240 0 0 0
Spleen 112 0 0 0
Brain_Caudate_basal_ganglia 76 0 0 1
Muscle_Skeletal 234 0 0 0
Brain_Cerebellum 151 0 0 1
Esophagus_Gastroesophageal_Junction 116 0 0 1
Lung 240 0 0 0
Thyroid 308 0 0 0
Liver 72 0 0 0
Brain_Amygdala 23 0 0 0
Colon_Sigmoid 117 0 0 0
Whole_Blood 195 0 0 1

4. T2D

T2D_Met - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to T2D_met : 308 
## ## Significant by Presso after bonferroni correction: 39
IV Gene Presso.b Presso.se Presso.p
33 37 AGER, RAGE -0.0747336 0.0146821 0.0000114
37 18 AGRP, AGRT, ART 0.0787034 0.0091098 0.0000001
96 18 APOL1, APOL 0.0368602 0.0073682 0.0001090
137 20 ASPN, PLAP1, SLRR1C, UNQ215, PRO241 0.0457977 0.0051805 0.0000000
273 13 CCL19, ELC, MIP3B, SCYA19 -0.0498743 0.0076178 0.0000274
296 35 CD177, NB1, PRV1, UNQ595, PRO1181 0.0435306 0.0097732 0.0000866
312 20 CD34 0.0455711 0.0065557 0.0000013
437 12 COLGALT1, GLT25D1, PSEC0241 0.1699666 0.0141615 0.0000003
460 51 CRISP2, GAPDL5, TPX1 0.0785846 0.0054246 0.0000000
494 28 CTSS 0.0733858 0.0079269 0.0000000
549 22 DHX8, DDX8 0.0515221 0.0105912 0.0000826
564 20 DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537, PRO1080 0.0806861 0.0074106 0.0000000
751 20 FLT4, VEGFR3 -0.0557962 0.0104383 0.0000370
824 13 GP1BA 0.1851738 0.0200169 0.0000008
865 16 GZMA, CTLA3, HFSP 0.2417913 0.0214658 0.0000000
884 12 HDHD2 -0.1158133 0.0097306 0.0000001
999 46 IL21 -0.0703808 0.0111054 0.0000001
1048 24 ITIH1, IGHEP1 0.0489892 0.0096174 0.0000370
1057 31 JAKMIP3, C10orf14, C10orf39, JAMIP3, NECC2 -0.0505625 0.0083343 0.0000012
1084 40 KIR2DS2, CD158J, NKAT5 -0.2003950 0.0145387 0.0000000
1117 11 LAMB1, LAMC1, LAMB2, LAMA1, LAMA -0.1506338 0.0254961 0.0001494
1308 18 NAAA, ASAHL, PLT 0.0570978 0.0110907 0.0000804
1309 41 NAALAD2 -0.0838812 0.0122442 0.0000000
1316 14 NAT1, AAC1 0.0988337 0.0163049 0.0000402
1357 12 NMES1, C15orf48 -0.1259888 0.0187019 0.0000321
1391 19 NSF 0.2312855 0.0296101 0.0000005
1438 43 PAM -0.1174716 0.0088944 0.0000000
1446 13 PAXIP1, PAXIP1L, PTIP, CAGF28 0.0982232 0.0143369 0.0000177
1468 111 PDE4D, DPDE3 -0.0141801 0.0030814 0.0000112
1474 20 PDGFRA, PDGFR2, RHEPDGFRA 0.0507123 0.0095025 0.0000377
1586 74 PRSS3, PRSS4, TRY3, TRY4 -0.0525105 0.0113532 0.0000156
1593 19 PSG3 -0.0273863 0.0053434 0.0000709
1606 12 PTH2, TIP39, TIPF39 0.2559822 0.0341956 0.0000122
1736 13 S100A13 0.0701567 0.0090005 0.0000049
1812 38 SIGIRR, UNQ301, PRO342 -0.0478582 0.0086223 0.0000033
1896 49 ST3GAL6, SIAT10 0.0358571 0.0062201 0.0000006
1969 36 TFF3, ITF, TFI 0.0947433 0.0147395 0.0000002
2047 11 TPST1 0.0807894 0.0081959 0.0000018
2106 14 VCAM1 0.1620857 0.0251913 0.0000222

T2D_Met Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1269 133 5 ARFGAP2, MSRA, RBM39, SERPINC1, TPM2 7 HDHD2, LAMC1, NAT1, PAM, TPST1
Gevadis 205 1 0 4 HDHD2
Prostate 83 1 0 0
Nerve_Tibial 725 10 3 MDH1, SERPINC1, ZAP70 5 CTSS, HDHD2, LAMC1
Minor_Salivary_Gland 61 0 0 0
Brain_Nucleus_accumbens_basal_ganglia 138 0 0 0
Small_Intestine_Terminal_Ileum 91 2 1 C4A 1
Pituitary 192 1 0 2
Adipose_Subcutaneous 551 12 2 CTSS, SERPINC1 CTSS 5 CTSS, GP1BA, S100A13
Skin_Sun_Exposed_Lower_leg 619 14 1 CTSS CTSS 6 CTSS, PAM, S100A13, SIGIRR
Esophagus_Mucosa 565 9 1 SERPINC1 5 LAMA1, TPST1
Brain_Hypothalamus 83 1 0 0
Breast_Mammary_Tissue 272 2 0 2 HDHD2
Brain_Anterior_cingulate_cortex_BA24 100 0 0 1
Adrenal_Gland 246 2 0 1
Artery_Aorta 423 4 1 CPNE1 3 CTSS
Brain_Substantia_nigra 59 0 0 0
Cells_EBV-transformed_lymphocytes 128 2 0 0 HDHD2, S100A13
Pancreas 340 2 0 1
Brain_Cortex 188 1 0 0 PRSS3
Brain_Hippocampus 98 0 0 1
Brain_Frontal_Cortex_BA9 131 1 0 1 S100A13
Artery_Tibial 584 6 1 CTSS CTSS 5 CTSS, HDHD2, S100A13, ST3GAL6
Uterus 58 0 0 0
Adipose_Visceral_Omentum 363 7 2 MDH1, SERPINC1 4 CTSS, HDHD2
Artery_Coronary 141 2 0 0
Colon_Transverse 270 2 0 2 CTSS
Stomach 224 1 0 1
Vagina 51 1 0 0
Heart_Atrial_Appendage 351 3 0 2
Brain_Putamen_basal_ganglia 125 0 0 1
Brain_Spinal_cord_cervical_c-1 78 1 0 0
Skin_Not_Sun_Exposed_Suprapubic 460 7 0 4
Testis 441 1 0 0 TFF3
Ovary 102 1 0 1
Heart_Left_Ventricle 327 5 1 HLA-DQA2 2 LAMC1
Cells_Transformed_fibroblasts 531 2 0 3 HDHD2
Brain_Cerebellar_Hemisphere 225 2 0 0 LAMC1, PAM
Esophagus_Muscularis 519 7 1 SERPINC1 4 HDHD2
Spleen 217 2 0 0
Brain_Caudate_basal_ganglia 176 1 0 1 CTSS
Muscle_Skeletal 547 6 1 RHOA 1
Brain_Cerebellum 351 3 0 0 PAM
Esophagus_Gastroesophageal_Junction 259 1 0 2 GP1BA
Lung 526 5 0 5 CTSS, HDHD2, LAMC1
Thyroid 668 11 0 4 PAM, S100A13, TFF3
Liver 148 2 0 1
Brain_Amygdala 56 1 0 0 S100A13
Colon_Sigmoid 271 1 0 1 CTSS, S100A13
Whole_Blood 473 5 0 1 LAMC1, PAM, S100A13

T2D_DIA - INTERVAL significant gene:

## ## IVs>= 8 INTERVAL proteins to T2D_dia : 58 
## ## Significant by Presso after bonferroni correction: 4
IV Gene Presso.b Presso.se Presso.p
222 8 CPNE1, CPN1 -0.0673918 0.0079645 0.0000636
432 8 GZMA, CTLA3, HFSP 0.2777327 0.0420137 0.0003013
541 16 KIR2DS2, CD158J, NKAT5 -0.2574434 0.0160225 0.0000000
716 9 PAM -0.0870273 0.0167204 0.0008175

Overlaps of T2D_DIA and T2D_MET

## [1] "GZMA, CTLA3, HFSP"      "KIR2DS2, CD158J, NKAT5"
## [3] "PAM"

T2D_DIA Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 639 9 0 3
Gevadis 73 0 0 1
Prostate 67 0 0 0
Nerve_Tibial 292 1 1 CKAP2 1 CPNE1
Minor_Salivary_Gland 19 0 0 0
Brain_Nucleus_accumbens_basal_ganglia 46 0 0 0
Small_Intestine_Terminal_Ileum 28 0 0 0
Pituitary 78 0 0 1
Adipose_Subcutaneous 236 0 0 1 CPNE1
Skin_Sun_Exposed_Lower_leg 254 0 0 0
Esophagus_Mucosa 228 0 0 0 CPNE1
Brain_Hypothalamus 27 0 0 0
Breast_Mammary_Tissue 87 0 0 1
Brain_Anterior_cingulate_cortex_BA24 28 0 0 0
Adrenal_Gland 96 0 0 0 CPNE1
Artery_Aorta 160 0 0 0 CPNE1
Brain_Substantia_nigra 22 0 0 0
Cells_EBV-transformed_lymphocytes 45 0 0 0
Pancreas 134 0 0 0 CPNE1
Brain_Cortex 60 0 0 0
Brain_Hippocampus 40 0 0 0
Brain_Frontal_Cortex_BA9 39 0 0 0
Artery_Tibial 231 0 0 2 CPNE1
Uterus 19 0 0 0 CPNE1
Adipose_Visceral_Omentum 140 0 0 0 CPNE1
Artery_Coronary 39 0 0 0
Colon_Transverse 103 0 0 0
Stomach 82 0 0 0
Vagina 18 0 0 0
Heart_Atrial_Appendage 131 1 0 1
Brain_Putamen_basal_ganglia 45 0 0 0
Brain_Spinal_cord_cervical_c-1 34 0 0 0
Skin_Not_Sun_Exposed_Suprapubic 176 0 0 1 CPNE1
Testis 175 0 0 0 CPN1
Ovary 37 0 0 1
Heart_Left_Ventricle 129 0 0 0 CPNE1
Cells_Transformed_fibroblasts 210 0 0 1
Brain_Cerebellar_Hemisphere 93 0 0 0 PAM
Esophagus_Muscularis 200 0 0 0 CPNE1
Spleen 95 0 0 0
Brain_Caudate_basal_ganglia 67 0 0 0
Muscle_Skeletal 197 0 0 0
Brain_Cerebellum 133 0 0 0 PAM
Esophagus_Gastroesophageal_Junction 94 0 0 0
Lung 197 0 0 0 CPNE1
Thyroid 263 0 0 1 CPNE1
Liver 58 0 0 0
Brain_Amygdala 20 0 0 0
Colon_Sigmoid 101 0 0 1
Whole_Blood 162 1 0 0

6. CHD

CHD_C4 - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to CHD_c4 : 267 
## ## Significant by Presso after bonferroni correction: 44
IV Gene Presso.b Presso.se Presso.p
28 31 ADH1B, ADH2 0.0927309 0.0091695 0.0000000
37 19 AGRP, AGRT, ART -0.0529032 0.0058976 0.0000000
64 15 ANGPTL1, ANG3, ANGPT3, ARP1, PSEC0154, UNQ162, PRO188 -0.0389463 0.0075649 0.0001479
131 62 ASIP, AGTI, AGTIL, ASP -0.0233817 0.0038123 0.0000001
210 18 C1QTNF1, CTRP1, UNQ310, PRO353 0.1526396 0.0153273 0.0000000
218 12 C5orf38, CEI 0.1549084 0.0160150 0.0000010
351 16 CFH, HF, HF1, HF2 -0.0406936 0.0074853 0.0000688
443 17 CREB3L4, AIBZIP, CREB4, JAL 0.0815637 0.0079811 0.0000000
474 11 CTF1 0.1576206 0.0171541 0.0000034
478 16 CTSA, PPGB 0.0647963 0.0115751 0.0000509
556 15 DOCK9, KIAA1058, ZIZ1 0.1662622 0.0184016 0.0000003
637 13 ERAP2, LRAP 0.0250633 0.0019636 0.0000000
674 13 FAM171B, KIAA1946, NPD019 0.0926614 0.0052068 0.0000000
722 30 FKBP6, FKBP36 0.0295802 0.0053557 0.0000059
747 15 FYN -0.0331431 0.0053045 0.0000213
771 22 GEM, KIR 0.0348027 0.0053329 0.0000018
799 13 GP1BA 0.3671448 0.0215462 0.0000000
823 51 GRIA4, GLUR4 0.0428945 0.0050624 0.0000000
825 17 GRN 0.1260438 0.0140150 0.0000002
867 15 HINT1, HINT, PKCI1, PRKCNH1 0.0388076 0.0047533 0.0000011
887 54 HP -0.0242721 0.0041649 0.0000003
992 17 IL6R -0.0481572 0.0069325 0.0000033
993 16 IL6R -0.0489270 0.0059611 0.0000006
1039 11 KDELC2, UNQ1904, PRO4350 0.0468832 0.0077925 0.0001292
1076 10 KPNA2, RCH1, SRP1 0.0998455 0.0108013 0.0000069
1215 50 MICB, PERB11.2 0.0293890 0.0038996 0.0000000
1218 30 MINOS1, C1orf151, MIC10 0.0260709 0.0044101 0.0000020
1275 36 NAALAD2 0.0662920 0.0071979 0.0000000
1300 11 NDUFB4 0.0452489 0.0072556 0.0000967
1402 41 PAM 0.0290441 0.0041902 0.0000000
1431 52 PDE4D, DPDE3 0.0347472 0.0053095 0.0000000
1458 13 PGRMC2, DG6, PMBP -0.0256843 0.0047303 0.0001526
1522 77 PRDM1, BLIMP1 0.0384850 0.0064470 0.0000001
1594 18 RAB26 0.0612444 0.0099812 0.0000110
1785 10 SIRT5, SIR2L5 0.0724080 0.0119321 0.0001863
1876 40 STOM, BND7, EPB72 0.0631337 0.0098119 0.0000002
1920 58 TDGF1, CRIPTO -0.0349072 0.0059989 0.0000003
1934 18 THSD1, TMTSP, UNQ3010, PRO9769 -0.0847102 0.0125833 0.0000067
1961 46 TMPRSS11D, HAT 0.0491787 0.0073868 0.0000000
1986 34 TNS2, KIAA1075, TENC1 0.0676435 0.0106540 0.0000005
2000 11 TPST1 -0.0489370 0.0057968 0.0000073
2057 14 VCAM1 0.3491490 0.0095018 0.0000000
2064 18 VPS29, DC15, DC7, MDS007 -0.0937039 0.0111719 0.0000002
2073 28 VTN 0.0269593 0.0042382 0.0000008

CHD_C4 Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1281 135 5 ARFGAP2, IER3, LRRC37A2, TPST1, VARS2 TPST1 9 ERAP2, HP, TPST1, VPS29
Gevadis 206 1 1 LRRC37A2 2 ERAP2, MICB
Prostate 81 0 0 0 ERAP2
Nerve_Tibial 714 7 3 CKAP2, CPNE1, FOLH1 2 ADH1B, CREB3L4, ERAP2, TPST1, VPS29
Minor_Salivary_Gland 57 0 0 1 ERAP2
Brain_Nucleus_accumbens_basal_ganglia 136 0 0 0 ERAP2
Small_Intestine_Terminal_Ileum 87 0 0 1 ERAP2
Pituitary 189 0 0 0 ERAP2
Adipose_Subcutaneous 542 8 1 TPST1 TPST1 2 ADH1B, CREB3L4, ERAP2, FAM171B, TPST1
Skin_Sun_Exposed_Lower_leg 615 7 2 CPNE1, FOLH1 2 ASIP, ERAP2, FAM171B, VPS29
Esophagus_Mucosa 549 5 0 5 ERAP2, TPST1, VPS29
Brain_Hypothalamus 79 0 0 0 ERAP2
Breast_Mammary_Tissue 268 0 0 5 ERAP2, FAM171B
Brain_Anterior_cingulate_cortex_BA24 96 0 0 2 ERAP2
Adrenal_Gland 242 0 0 2 ERAP2
Artery_Aorta 419 1 0 5 CREB3L4, ERAP2
Brain_Substantia_nigra 56 0 0 0 ERAP2
Cells_EBV-transformed_lymphocytes 123 0 0 0 ERAP2
Pancreas 338 0 0 2 ERAP2, GRIA4
Brain_Cortex 176 0 0 0 ERAP2
Brain_Hippocampus 94 0 0 1 ERAP2
Brain_Frontal_Cortex_BA9 123 0 0 0 ERAP2
Artery_Tibial 573 3 2 ABHD12, FOLH1 6 IL6R ADH1B, CREB3L4, ERAP2, IL6R
Uterus 55 0 0 0 ERAP2
Adipose_Visceral_Omentum 362 4 2 CPNE1, TPST1 TPST1 2 ERAP2, TPST1, VPS29
Artery_Coronary 138 0 0 0 ERAP2
Colon_Transverse 266 1 1 CKAP2 2 IL6R ERAP2, IL6R
Stomach 221 0 0 0 ERAP2, FAM171B
Vagina 49 0 0 1 ERAP2
Heart_Atrial_Appendage 345 2 0 1 ERAP2
Brain_Putamen_basal_ganglia 122 0 0 1 ERAP2
Brain_Spinal_cord_cervical_c-1 75 0 0 2 ERAP2, NAALAD2
Skin_Not_Sun_Exposed_Suprapubic 454 5 1 CPNE1 2 ERAP2
Testis 431 0 0 3 IL6R ERAP2, IL6R
Ovary 98 0 0 0 ERAP2
Heart_Left_Ventricle 324 3 1 TPST1 TPST1 2 ERAP2, HP, TPST1
Cells_Transformed_fibroblasts 519 0 0 1 ADH1B, CREB3L4, DOCK9, ERAP2, FAM171B, VPS29
Brain_Cerebellar_Hemisphere 223 0 0 1 ERAP2
Esophagus_Muscularis 510 4 0 0 CREB3L4, ERAP2, VPS29
Spleen 218 0 0 2 ERAP2, VPS29
Brain_Caudate_basal_ganglia 171 0 0 1 ERAP2
Muscle_Skeletal 535 3 2 RHOA, TPST1 TPST1 4 CREB3L4, ERAP2, TPST1
Brain_Cerebellum 343 1 1 NRG4 1 ERAP2
Esophagus_Gastroesophageal_Junction 252 0 0 2 ERAP2
Lung 520 2 1 TPST1 TPST1 3 CREB3L4, ERAP2, FAM171B, HP, TPST1
Thyroid 660 8 2 CKAP2, TPST1 TPST1 1 CREB3L4, ERAP2, FAM171B, TPST1, VPS29
Liver 148 0 0 3 ERAP2
Brain_Amygdala 53 0 0 0 ERAP2
Colon_Sigmoid 266 0 0 5 CREB3L4, ERAP2, FAM171B
Whole_Blood 459 2 0 2 IL6R ERAP2, IL6R

CHD_UKBB - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to CHD_ukbb : 324 
## ## Significant by Presso after bonferroni correction: 71
IV Gene Presso.b Presso.se Presso.p
33 32 AGER, RAGE 0.0462800 0.0060081 0.0000000
94 29 APOL1, APOL 0.0311648 0.0041439 0.0000000
132 59 ASIP, AGTI, AGTIL, ASP 0.0154328 0.0022839 0.0000000
251 9 CAST 0.0317079 0.0042317 0.0000697
367 8 CGREF1, CGR11 0.0398491 0.0027637 0.0000018
480 31 CST7 -0.0142405 0.0026403 0.0000077
487 15 CTSA, PPGB -0.0566558 0.0096566 0.0000410
492 25 CTSS -0.0113475 0.0015525 0.0000002
547 10 DKK1, UNQ492, PRO1008 -0.0895504 0.0119308 0.0000367
622 26 EMC4, TMEM85, HSPC184, PIG17 0.0126554 0.0017504 0.0000001
690 11 FAM174A, NS5ATP6, TMEM157, UNQ1912, PRO4371 0.0269426 0.0040262 0.0000542
719 8 FCRL3, FCRH3, IFGP3, IRTA3, SPAP2 -0.0473361 0.0046887 0.0000201
720 10 FCRL4, FCRH4, IFGP2, IRTA1 -0.0284559 0.0043477 0.0001058
974 11 IL18R1, IL1RRP -0.0259104 0.0040228 0.0000743
975 19 IL18R1, IL1RRP -0.0206047 0.0030100 0.0000021
983 15 IL1RL1, DER4, ST2, T1 -0.0197263 0.0036694 0.0000978
986 40 IL21 0.0148517 0.0025277 0.0000008
1069 39 KIR2DS2, CD158J, NKAT5 0.0313033 0.0036965 0.0000000
1091 10 KPNA2, RCH1, SRP1 -0.0453481 0.0069550 0.0001089
1111 44 LCT, LPH -0.0341371 0.0039539 0.0000000
1244 76 MMP8, CLG1 0.0083660 0.0013384 0.0000000
1290 38 NAALAD2 0.0107424 0.0025017 0.0001217
1430 11 PCDHA7, CNRS4 -0.0219447 0.0024592 0.0000045
1492 21 PLA2R1, CLEC13C 0.0142203 0.0022967 0.0000048
1560 66 PRSS3, PRSS4, TRY3, TRY4 0.0245068 0.0036879 0.0000000
1580 11 PTH2, TIP39, TIPF39 -0.0858435 0.0088452 0.0000021
1614 65 RACGAP1, KIAA1478, MGCRACGAP 0.0320492 0.0044361 0.0000000
1708 12 S100A13 -0.1397919 0.0043315 0.0000055
1724 11 SCG3, UNQ2502, PRO5990 -0.0222204 0.0034876 0.0000813
1796 10 SIRT5, SIR2L5 -0.1101308 0.0081618 0.0000003
1847 9 SPINK6, UNQ844, PRO1782 0.0126312 0.0011920 0.0000055
1866 49 ST3GAL6, SIAT10 -0.0061126 0.0011161 0.0000016
1921 13 TAPBP, NGS17, TAPA 0.0171565 0.0012825 0.0000000
1924 10 TBCA -0.1231192 0.0051444 0.0000181
1938 36 TFF3, ITF, TFI -0.0178671 0.0019702 0.0000000
1952 8 TIMP4 0.0746565 0.0078725 0.0000783
2001 56 TNXB, HXBL, TNX, TNXB1, TNXB2, XB -0.0057139 0.0009379 0.0000001
2064 53 USP25, USP21 0.0160504 0.0013941 0.0000000
2078 20 VPS29, DC15, DC7, MDS007 -0.0468907 0.0044969 0.0000000

Overlaps of CHD_ukbb and CHD_C4

##  [1] "ADH1B, ADH2"                    "AGRP, AGRT, ART"               
##  [3] "ASIP, AGTI, AGTIL, ASP"         "C1QTNF1, CTRP1, UNQ310, PRO353"
##  [5] "C5orf38, CEI"                   "CTF1"                          
##  [7] "DOCK9, KIAA1058, ZIZ1"          "ERAP2, LRAP"                   
##  [9] "FAM171B, KIAA1946, NPD019"      "FYN"                           
## [11] "GP1BA"                          "GRIA4, GLUR4"                  
## [13] "GRN"                            "KDELC2, UNQ1904, PRO4350"      
## [15] "KPNA2, RCH1, SRP1"              "MICB, PERB11.2"                
## [17] "NAALAD2"                        "PAM"                           
## [19] "PDE4D, DPDE3"                   "PRDM1, BLIMP1"                 
## [21] "STOM, BND7, EPB72"              "TDGF1, CRIPTO"                 
## [23] "THSD1, TMTSP, UNQ3010, PRO9769" "TMPRSS11D, HAT"                
## [25] "TNS2, KIAA1075, TENC1"          "TPST1"                         
## [27] "VCAM1"                          "VPS29, DC15, DC7, MDS007"

CHD_UKBB Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1358 162 4 LRRC37A2, MAPKAPK5, SERPINC1, TNFSF4 4 C4A, CD34, CPNE1, ERAP2, GPX7, JAKMIP3, NQO1, VPS29
Gevadis 232 1 1 LRRC37A2 1 CPNE1, ERAP2, HLA-DQA2, MICB
Prostate 100 1 1 LRRC37A2 1 CPNE1, ERAP2
Nerve_Tibial 819 13 6 C4A, CLCF1, CPNE1, LRRC37A2, MDH1, SERPINC1 C4A, CPNE1 4 ADH1B, C4A, CPNE1, ERAP2, HLA-DQA2, NQO1, POFUT2, TAPBP, VPS29
Minor_Salivary_Gland 63 0 0 2 CPNE1, ERAP2
Brain_Nucleus_accumbens_basal_ganglia 159 1 1 LRRC37A2 2 CPNE1, ERAP2
Small_Intestine_Terminal_Ileum 108 2 2 C4A, LRRC37A2 C4A 3 C4A, CPNE1, ERAP2
Pituitary 212 1 1 C4A C4A 2 C4A C4A, CPNE1, ERAP2, HLA-DQA2, LRPAP1
Adipose_Subcutaneous 619 13 4 C4A, LRRC37A2, MDH1, SERPINC1 C4A 5 ADH1B, C4A, CPNE1, ERAP2, GPX7, HLA-DQA2
Skin_Sun_Exposed_Lower_leg 704 14 5 ASIP, C4A, C4B, CROT, LRRC37A2 ASIP, C4A, C4B 7 C4B ASIP, C4A, C4B, ERAP2, HLA-DQA2, LRPAP1, VPS29
Esophagus_Mucosa 643 12 5 C4A, CROT, LRRC37A2, SERPINC1, VARS2 C4A 8 C4A C4A, CPNE1, ERAP2, PLA2R1, TAPBP, TPST1, VPS29
Brain_Hypothalamus 92 1 1 LRRC37A2 1 CPNE1, ERAP2
Breast_Mammary_Tissue 304 2 2 C4A, LRRC37A2 C4A 6 C4A C4A, CPNE1, ERAP2, HLA-DQA2
Brain_Anterior_cingulate_cortex_BA24 119 0 0 1 CPNE1, ERAP2, HLA-DQA2
Adrenal_Gland 282 2 2 C4A, LRRC37A2 C4A 3 C4A, C4B, CPNE1, ERAP2, TFF3
Artery_Aorta 490 5 3 C4A, CPNE1, VARS2 C4A, CPNE1 4 C4A C4A, CPNE1, ERAP2, MICB, TAPBP
Brain_Substantia_nigra 64 0 0 0 CPNE1, ERAP2
Cells_EBV-transformed_lymphocytes 133 2 2 C4A, LRRC37A2 C4A 2 C4A, CPNE1, ERAP2
Pancreas 383 4 3 C4A, HLA-DMA, LRRC37A2 C4A 3 C4A C4A, CPNE1, ERAP2
Brain_Cortex 209 1 1 LRRC37A2 2 CPNE1, ERAP2, HLA-DQA2
Brain_Hippocampus 108 0 0 0 CPNE1, ERAP2, HLA-DQA2
Brain_Frontal_Cortex_BA9 151 0 0 1 CPNE1, ERAP2, HLA-DQA2
Artery_Tibial 672 10 4 ABHD12, C4A, P4HA2, SERPINC1 C4A 5 ADH1B, C1QTNF1, C4A, ERAP2, GPX7, NAALAD2, TAPBP, VPS29
Uterus 70 0 0 0 CPNE1, ERAP2, HLA-DQA2
Adipose_Visceral_Omentum 426 7 4 C4A, LRRC37A2, MDH1, SERPINC1 C4A 6 C4A, CPNE1, MICB, VPS29
Artery_Coronary 159 2 2 C4A, LRRC37A2 C4A 3 C4A, CPNE1, ERAP2, MICB
Colon_Transverse 313 3 2 C4A, LRRC37A2 C4A 2 C4A, CPNE1, ERAP2
Stomach 248 3 3 C4A, CSDC2, LRRC37A2 C4A 3 C4A C4A, CPNE1, ERAP2
Vagina 60 1 1 LRRC37A2 3 CPNE1, ERAP2
Heart_Atrial_Appendage 398 3 1 C4A C4A 4 C4A C4A, CPNE1, ERAP2, FRZB, GPX7, TAPBP
Brain_Putamen_basal_ganglia 139 0 0 1 CPNE1, ERAP2, HLA-DQA2
Brain_Spinal_cord_cervical_c-1 89 1 1 LRRC37A2 1 ERAP2
Skin_Not_Sun_Exposed_Suprapubic 531 10 4 ASIP, C4A, C4B, LRRC37A2 ASIP, C4A, C4B 5 ASIP, C4A, C4B, CPNE1, ERAP2, LRPAP1
Testis 505 5 2 C4A, VARS2 C4A 3 C4A, CPNE1, ERAP2
Ovary 124 1 1 LRRC37A2 2 ERAP2, HLA-DQA2
Heart_Left_Ventricle 378 9 3 C4A, LRRC37A2, SERPINC1 C4A 6 C4A, ERAP2, TAPBP
Cells_Transformed_fibroblasts 598 4 3 C4A, C4B, LRRC37A2 C4A, C4B 4 C4B ADH1B, C1QTNF1, C4A, C4B, CPNE1, ERAP2, LRPAP1, POFUT2, PRELP, TAPBP, VPS29
Brain_Cerebellar_Hemisphere 253 3 2 C4A, LRRC37A2 C4A 1 C4A, CPNE1, ERAP2, HLA-DQA2, LRPAP1
Esophagus_Muscularis 601 8 2 C4A, SERPINC1 C4A 3 C4A C4A, CPNE1, ERAP2, FAM171B, HLA-DQA2, TAPBP
Spleen 251 3 2 C4A, LRRC37A2 C4A 2 VPS29 C4A, CPNE1, ERAP2, VPS29
Brain_Caudate_basal_ganglia 206 1 1 C4A C4A 0 C4A, CPNE1, ERAP2
Muscle_Skeletal 618 9 4 ARPC3, C4A, MAPKAPK3, SERPINC1 C4A 6 C4A, CPNE1, DOCK9, NQO1, TAPBP, VPS29
Brain_Cerebellum 386 4 2 C4A, LRRC37A2 C4A 3 C4A, CPNE1, ERAP2, LRPAP1, PAM
Esophagus_Gastroesophageal_Junction 298 2 2 C4A, LRRC37A2 C4A 4 C4A C4A, CPNE1, ERAP2, HLA-DQA2
Lung 592 7 3 C4A, LRRC37A2, SERPINC1 C4A 6 C4A, C4B, CPNE1, ERAP2, GPX7
Thyroid 757 15 2 C4A, SERPINC1 C4A 5 C4A C4A, C4B, ERAP2, MICB, PLA2R1, TAPBP, VPS29
Liver 164 2 2 C4A, HLA-DMA C4A 5 C4A C4A, CPNE1, ERAP2
Brain_Amygdala 66 2 2 C4A, LRRC37A2 C4A 1 C4A, ERAP2, HLA-DQA2
Colon_Sigmoid 302 3 2 C4A, LRRC37A2 C4A 2 C4A, CPNE1, ERAP2, HLA-DQA2, PLA2R1, TAPBP
Whole_Blood 532 5 4 C4A, C4B, LRRC37A2, MICB C4A, C4B, MICB 2 C4A, C4B, DOCK9, ERAP2, HLA-DQA2, MICB, PAM, THSD1, VPS29

AF - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to AF : 323 
## ## Significant by Presso after bonferroni correction: 55
IV Gene Presso.b Presso.se Presso.p
37 20 AGRP, AGRT, ART 0.0659029 0.0033337 0.0000000
43 33 AKR1A1, ALDR1, ALR -0.0188700 0.0034949 0.0000062
133 62 ASIP, AGTI, AGTIL, ASP 0.0188288 0.0025924 0.0000000
137 20 ASPN, PLAP1, SLRR1C, UNQ215, PRO241 0.0475156 0.0030295 0.0000000
312 20 CD34 0.0543906 0.0037053 0.0000000
326 66 CD96 -0.0199295 0.0044024 0.0000261
449 27 CPNE1, CPN1 -0.0416447 0.0039925 0.0000000
454 45 CREB3L4, AIBZIP, CREB4, JAL -0.0228217 0.0043025 0.0000035
482 45 CST7 -0.0222730 0.0052681 0.0001208
489 16 CTSA, PPGB 0.1851425 0.0272441 0.0000087
553 10 DKK1, UNQ492, PRO1008 0.2128643 0.0293643 0.0000881
555 16 DKK4 0.1519108 0.0226640 0.0000219
565 21 DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537, PRO1080 -0.1238165 0.0101111 0.0000000
580 14 DRGX, PRRXL1 -0.1291591 0.0129241 0.0000002
596 18 EDA2R, TNFRSF27, XEDAR, UNQ2448, PRO5727, PRO34080 0.0657381 0.0034500 0.0000000
657 14 ERAP2, LRAP 0.0104789 0.0017486 0.0000450
696 13 FAM171B, KIAA1946, NPD019 -0.0351524 0.0046570 0.0000068
733 11 FGF7, KGF 0.0859127 0.0110473 0.0000151
771 16 FYN -0.0209227 0.0030288 0.0000050
781 26 GALNT1 0.0453595 0.0078500 0.0000051
784 19 GC 0.0270498 0.0052247 0.0000634
866 18 GZMA, CTLA3, HFSP -0.0616995 0.0099434 0.0000096
879 14 HBEGF, DTR, DTS, HEGFL 0.2276143 0.0181257 0.0000002
901 48 HLA-DQA2, HLA-DXA -0.0244846 0.0045416 0.0000022
1000 47 IL21 -0.0353309 0.0053429 0.0000000
1024 17 IL6R -0.0425121 0.0057415 0.0000015
1025 17 IL6R -0.0428407 0.0057446 0.0000014
1041 28 ISG15, G1P2, UCRP 0.0286005 0.0051747 0.0000074
1043 11 ISLR2, KIAA1465, LINX, UNQ1885, PRO4329 -0.0596973 0.0066597 0.0000043
1050 24 ITIH1, IGHEP1 -0.0175176 0.0032773 0.0000199
1086 43 KIR2DS2, CD158J, NKAT5 0.0449086 0.0042220 0.0000000
1109 10 KPNA2, RCH1, SRP1 0.1236100 0.0128495 0.0000049
1130 49 LCT, LPH 0.0176367 0.0028616 0.0000001
1174 86 LRPAP1, A2MRAP -0.0414968 0.0024880 0.0000000
1175 75 LRPAP1, A2MRAP -0.0474425 0.0026588 0.0000000
1209 15 MANBA, MANB1 0.0540204 0.0031396 0.0000000
1252 135 MICB, PERB11.2 0.0106241 0.0024936 0.0000381
1261 18 MMP12, HME -0.0326099 0.0043247 0.0000008
1266 83 MMP8, CLG1 -0.0224002 0.0028595 0.0000000
1314 42 NAALAD2 -0.0567233 0.0052880 0.0000000
1321 15 NAT1, AAC1 -0.0361318 0.0055089 0.0000127
1443 45 PAM -0.0382967 0.0027473 0.0000000
1466 15 PCSK1, NEC1 -0.0224138 0.0032285 0.0000068
1641 18 RAB26 0.0728577 0.0113049 0.0000060
1821 20 SIGLEC10, SLG2, UNQ477, PRO940 0.0257899 0.0052892 0.0001049
1835 10 SIRT5, SIR2L5 0.2339223 0.0267752 0.0000109
1906 52 ST3GAL6, SIAT10 -0.0190949 0.0024346 0.0000000
1946 16 SUSD2 0.0274083 0.0053446 0.0001237
1980 36 TFF3, ITF, TFI -0.0954270 0.0051758 0.0000000
1992 19 TIE1, TIE -0.0287228 0.0057636 0.0000962
2019 47 TMPRSS11D, HAT -0.0148402 0.0034631 0.0000922
2046 34 TNS2, KIAA1075, TENC1 -0.0209293 0.0045241 0.0000553
2048 116 TNXB, HXBL, TNX, TNXB1, TNXB2, XB 0.0131669 0.0029386 0.0000177
2060 12 TPST1 0.0859396 0.0075645 0.0000002
2114 61 USP25, USP21 0.0367120 0.0035704 0.0000000

Overlaps of CHD_ukbb or CHD_C4 and AF

##  [1] "AGRP, AGRT, ART"             "ASIP, AGTI, AGTIL, ASP"     
##  [3] "CREB3L4, AIBZIP, CREB4, JAL" "CTSA, PPGB"                 
##  [5] "ERAP2, LRAP"                 "FAM171B, KIAA1946, NPD019"  
##  [7] "FYN"                         "IL6R"                       
##  [9] "KPNA2, RCH1, SRP1"           "MICB, PERB11.2"             
## [11] "NAALAD2"                     "PAM"                        
## [13] "RAB26"                       "SIRT5, SIR2L5"              
## [15] "TMPRSS11D, HAT"              "TNS2, KIAA1075, TENC1"      
## [17] "TPST1"
##  [1] "AGRP, AGRT, ART"                                    
##  [2] "ASIP, AGTI, AGTIL, ASP"                             
##  [3] "ASPN, PLAP1, SLRR1C, UNQ215, PRO241"                
##  [4] "CD34"                                               
##  [5] "CD96"                                               
##  [6] "CPNE1, CPN1"                                        
##  [7] "DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537, PRO1080"
##  [8] "EDA2R, TNFRSF27, XEDAR, UNQ2448, PRO5727, PRO34080" 
##  [9] "ERAP2, LRAP"                                        
## [10] "FAM171B, KIAA1946, NPD019"                          
## [11] "FYN"                                                
## [12] "GALNT1"                                             
## [13] "GZMA, CTLA3, HFSP"                                  
## [14] "HLA-DQA2, HLA-DXA"                                  
## [15] "IL21"                                               
## [16] "ISG15, G1P2, UCRP"                                  
## [17] "KIR2DS2, CD158J, NKAT5"                             
## [18] "KPNA2, RCH1, SRP1"                                  
## [19] "LRPAP1, A2MRAP"                                     
## [20] "MICB, PERB11.2"                                     
## [21] "NAALAD2"                                            
## [22] "PAM"                                                
## [23] "ST3GAL6, SIAT10"                                    
## [24] "TFF3, ITF, TFI"                                     
## [25] "TMPRSS11D, HAT"                                     
## [26] "TNS2, KIAA1075, TENC1"                              
## [27] "TPST1"                                              
## [28] "USP25, USP21"
##  [1] "AGRP, AGRT, ART"           "ASIP, AGTI, AGTIL, ASP"   
##  [3] "ERAP2, LRAP"               "FAM171B, KIAA1946, NPD019"
##  [5] "FYN"                       "KPNA2, RCH1, SRP1"        
##  [7] "MICB, PERB11.2"            "NAALAD2"                  
##  [9] "PAM"                       "TMPRSS11D, HAT"           
## [11] "TNS2, KIAA1075, TENC1"     "TPST1"

AF Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1280 133 5 ACP2, GSTO1, LRRC37A2, MSRA, TPST1 TPST1 9 CPNE1, ERAP2, MANBA, PAM, SIRT5, TPST1
Gevadis 205 1 1 LRRC37A2 8 CPNE1, MICB CPNE1, MICB
Prostate 86 1 1 LRRC37A2 2 CPNE1 CPNE1
Nerve_Tibial 731 10 2 CPNE1, FOLH1 CPNE1 10 CPNE1, MICB
Minor_Salivary_Gland 62 0 0 2 CPNE1 CPNE1
Brain_Nucleus_accumbens_basal_ganglia 140 0 0 2 CPNE1 CPNE1
Small_Intestine_Terminal_Ileum 93 2 2 C4A, LRRC37A2 3 CPNE1 CPNE1
Pituitary 196 1 1 C4A 5 CPNE1 CPNE1
Adipose_Subcutaneous 562 13 1 LRRC37A2 6 CPNE1, GALNT1
Skin_Sun_Exposed_Lower_leg 632 15 5 ASIP, ASL, C4B, CPNE1, FOLH1 ASIP, CPNE1 6 ASIP, CPNE1, PAM
Esophagus_Mucosa 576 9 3 ACP2, C4A, TPST1 TPST1 7 CPNE1 CPNE1, TPST1
Brain_Hypothalamus 86 0 0 3 CPNE1 CPNE1
Breast_Mammary_Tissue 275 2 1 C4A 6 CPNE1, MICB CPNE1, GALNT1, MICB
Brain_Anterior_cingulate_cortex_BA24 101 0 0 1 CPNE1 CPNE1
Adrenal_Gland 252 2 2 C4A, LRRC37A2 3 CPNE1 CPNE1
Artery_Aorta 432 5 2 C4A, CPNE1 CPNE1 6 CPNE1
Brain_Substantia_nigra 59 0 0 4 CPNE1
Cells_EBV-transformed_lymphocytes 128 2 1 LRRC37A2 3 CPNE1 CPNE1
Pancreas 347 3 2 C4A, LRRC37A2 5 CPNE1 CPNE1
Brain_Cortex 192 1 1 LRRC37A2 2 CPNE1 CPNE1
Brain_Hippocampus 100 0 0 1 CPNE1
Brain_Frontal_Cortex_BA9 131 1 1 LRRC37A2 0 CPNE1
Artery_Tibial 589 7 3 C4A, FOLH1, HLA-DMA 12 CPNE1, IL6R CPNE1, IL6R
Uterus 59 0 0 1 CPNE1
Adipose_Visceral_Omentum 371 7 5 C4A, CPNE1, LRRC37A2, MICB, TPST1 CPNE1, MICB, TPST1 5 CPNE1, MICB, TPST1
Artery_Coronary 141 2 2 C4A, LRRC37A2 2 CPNE1
Colon_Transverse 275 3 2 C4A, LRRC37A2 6 CPNE1, IL6R CPNE1, IL6R
Stomach 229 1 1 C4A 3 CPNE1 CPNE1, FAM171B
Vagina 53 1 1 LRRC37A2 2 CPNE1 CPNE1
Heart_Atrial_Appendage 354 3 3 C4A, CPNE1, FOLH1 CPNE1 7 CPNE1, PCSK1
Brain_Putamen_basal_ganglia 128 0 0 1 CPNE1
Brain_Spinal_cord_cervical_c-1 79 1 1 LRRC37A2 1
Skin_Not_Sun_Exposed_Suprapubic 468 8 4 C4B, CPNE1, FOLH1, LRRC37A2 CPNE1 5 CPNE1 CPNE1, DRGX
Testis 450 2 0 6 CPNE1, IL6R CPNE1, IL6R
Ovary 103 1 1 LRRC37A2 2
Heart_Left_Ventricle 335 7 2 C4A, LRRC37A2 7 CPNE1, MICB, TPST1
Cells_Transformed_fibroblasts 533 2 2 C4A, C4B 6 CPNE1, MANBA CPNE1, FAM171B, MANBA
Brain_Cerebellar_Hemisphere 230 2 1 C4A 5 CPNE1 CPNE1
Esophagus_Muscularis 526 7 2 C4A, FOLH1 6 CPNE1 CPNE1
Spleen 224 2 2 C4A, LRRC37A2 4 CPNE1 CPNE1, MANBA, MICB
Brain_Caudate_basal_ganglia 177 1 1 C4A 4 CPNE1 CPNE1
Muscle_Skeletal 556 8 1 TPST1 TPST1 5 CPNE1 CPNE1, FGF7, TPST1
Brain_Cerebellum 355 4 2 C4A, LRRC37A2 5 MANBA CPNE1, MANBA
Esophagus_Gastroesophageal_Junction 263 1 1 C4A 1 CPNE1
Lung 535 4 2 C4A, TPST1 TPST1 8 CPNE1 CPNE1, TPST1
Thyroid 680 12 1 C4A 9 CPNE1, MICB, PAM, TPST1
Liver 150 2 1 C4A 3 CPNE1 CPNE1
Brain_Amygdala 57 1 1 C4A 1 CPNE1
Colon_Sigmoid 276 1 1 C4A 3 CPNE1 CPNE1
Whole_Blood 482 6 4 C4A, C4B, LRRC37A2, MICB MICB 7 IL6R CPNE1, IL6R, MICB, PAM

7. T1D

T1D_Dryad - INTERVAL significant gene:

## ## IVs>= 10 INTERVAL proteins to T1D_Dryad : 244 
## ## Significant by Presso after bonferroni correction: 58
IV Gene Presso.b Presso.se Presso.p
21 29 ADH1B, ADH2 0.1049114 0.0191930 0.0000078
25 34 AGER, RAGE 0.2106505 0.0464380 0.0001804
27 20 AGRP, AGRT, ART -0.0549933 0.0067294 0.0000001
43 18 AMY1A, AMY1;, AMY1B, AMY1C, AMY1 0.1010263 0.0193343 0.0000686
69 26 APOL1, APOL -0.2290176 0.0213107 0.0000000
98 54 ASIP, AGTI, AGTIL, ASP 0.0517480 0.0081871 0.0000001
172 111 C4A, CO4, CPAMD2, C4B, CPAMD3;, C4B_2 -1.6463593 0.0328239 0.0000000
213 13 CCL19, ELC, MIP3B, SCYA19 0.2697936 0.0278733 0.0000005
253 10 CD55, CR, DAF -0.1546611 0.0214365 0.0000500
261 40 CD96 -2.1736210 0.0514046 0.0000000
270 12 CDH5 -0.1063626 0.0159281 0.0000348
358 10 COX8A, COX8, COX8L 0.1839420 0.0225604 0.0000190
368 40 CREB3L4, AIBZIP, CREB4, JAL -0.2342126 0.0486945 0.0000610
390 16 CST7 -0.1006180 0.0140340 0.0000032
435 58 DEFB119, DEFB120, DEFB19, DEFB20, UNQ2449, PRO5729 -1.8920621 0.0428657 0.0000000
457 19 DNAJB11, EDJ, ERJ3, HDJ9, PSEC0121, UNQ537, PRO1080 -0.6371312 0.0551779 0.0000000
463 16 DOCK9, KIAA1058, ZIZ1 0.1719018 0.0236627 0.0000028
501 36 EMC4, TMEM85, HSPC184, PIG17 -1.7873461 0.0825593 0.0000000
559 11 FAM171B, KIAA1946, NPD019 0.0879104 0.0151125 0.0001690
605 18 FLT4, VEGFR3 0.0985814 0.0153853 0.0000065
615 30 FTL, FTH1, FTH, FTHL6, OK, SW-cl.84, PIG15 -0.1978685 0.0313652 0.0000008
617 12 FUT10 -0.1322921 0.0236199 0.0001601
630 20 GALNT1 3.7529365 0.0620498 0.0000000
650 18 GLCE, KIAA0836 -0.0791491 0.0119644 0.0000044
667 10 GP1BA 1.5410399 0.1004245 0.0000003
682 14 GPX7, GPX6, UNQ469, PRO828 -0.0721435 0.0129440 0.0000902
688 96 GRIA4, GLUR4 -1.6558821 0.0262963 0.0000000
704 12 GZMA, CTLA3, HFSP 1.9581243 0.2341121 0.0001588
713 11 HAVCR2, TIM3, TIMD3 0.0948943 0.0158113 0.0001318
715 13 HBEGF, DTR, DTS, HEGFL -0.1476513 0.0087202 0.0000000
736 11 HNF4A, HNF4, NR2A1, TCF14 -3.3381032 0.2262274 0.0001228
757 10 ICAM5, TLCN, TLN 0.2711859 0.0381052 0.0001908
758 15 ICAM5, TLCN, TLN 0.1937595 0.0295780 0.0000273
841 19 ISG15, G1P2, UCRP 4.2302588 0.1153729 0.0000000
874 34 KIR2DS2, CD158J, NKAT5 -1.6739753 0.0851041 0.0000000
943 46 LRPAP1, A2MRAP -0.3158784 0.0263770 0.0000000
944 40 LRPAP1, A2MRAP -0.3684436 0.0312746 0.0000000
974 15 MANBA, MANB1 -0.1012581 0.0128266 0.0000016
1008 109 MICB, PERB11.2 -1.0144193 0.0168596 0.0000000
1020 68 MMP8, CLG1 -0.3343516 0.0426607 0.0000000
1061 28 NAALAD2 0.5784678 0.0675157 0.0000000
1072 18 NCR3, 1C7, LY117 0.5449627 0.0721231 0.0000067
1162 40 PAM 0.1817875 0.0154003 0.0000000
1168 12 PAXIP1, PAXIP1L, PTIP, CAGF28 -3.2109124 0.2619658 0.0000180
1187 97 PDE4D, DPDE3 -1.4480330 0.0262709 0.0000000
1241 19 POFUT1, FUT12, KIAA0180 -0.0754372 0.0133949 0.0000242
1262 57 PRDM1, BLIMP1 0.0742682 0.0109887 0.0000000
1279 66 PRSS3, PRSS4, TRY3, TRY4 0.5743280 0.0541754 0.0000000
1322 63 RACGAP1, KIAA1478, MGCRACGAP 1.4077941 0.1066094 0.0000000
1538 38 STOM, BND7, EPB72 0.0680442 0.0134077 0.0000112
1565 12 TAPBP, NGS17, TAPA -0.2818980 0.0336822 0.0000042
1573 60 TDGF1, CRIPTO 0.0766929 0.0145721 0.0000021
1574 11 TEK, TIE2, VMCM, VMCM1 -0.2086298 0.0254538 0.0000182
1579 36 TFF3, ITF, TFI -1.1853991 0.0936474 0.0000000
1609 44 TMPRSS11D, HAT 0.0542103 0.0111343 0.0000155
1628 76 TNXB, HXBL, TNX, TNXB1, TNXB2, XB 0.6674024 0.0625420 0.0000052
1673 57 USP25, USP21 -1.8728055 0.0540611 0.0000000
1677 10 VCAM1 1.4192121 0.0956017 0.0000001

AD_igap Overlap of INTERVAL to GTEx, Cage, Gevidas

Tissue proteins.n IV>3 Sig.Presso.n Sig.Presso.genes Overlap by Presso Sig.All.n Overlap by All Overlap by nominal
Cage 1205 121 4 HLA-DPB1, IER3, MSRA, VARS2 19 TAPBP FLT4, FTH1, GZMA, HAVCR2, MANBA, PAM, TAPBP
Gevadis 187 1 1 LRRC37A2 4 MICB
Prostate 77 1 1 LRRC37A2 5 AGER, C4A AGER, C4A
Nerve_Tibial 680 5 0 9 AGER, C4A, C4B, MICB AGER, C4A, C4B, MICB
Minor_Salivary_Gland 56 0 0 4 TAPBP TAPBP
Brain_Nucleus_accumbens_basal_ganglia 124 0 0 1
Small_Intestine_Terminal_Ileum 80 1 1 LRRC37A2 2 C4A C4A
Pituitary 179 0 0 6 C4A C4A
Adipose_Subcutaneous 512 8 2 LRRC37A2, MDH1 5 AGER, C4A, C4B, TAPBP AGER, C4A, C4B, ICAM5, TAPBP
Skin_Sun_Exposed_Lower_leg 574 8 2 C4B, CROT C4B 11 AGER, C4A, C4B, TAPBP AGER, C4A, C4B, ICAM5, PAM, TAPBP
Esophagus_Mucosa 520 6 2 CROT, TPST1 9 C4A, C4B, TAPBP C4A, C4B, MICB, TAPBP
Brain_Hypothalamus 75 0 0 4 C4A C4A
Breast_Mammary_Tissue 249 1 1 C4A C4A 4 AGER, MICB AGER, C4A, MICB
Brain_Anterior_cingulate_cortex_BA24 94 0 0 3 C4A, MICB C4A, MICB
Adrenal_Gland 233 1 1 LRRC37A2 5 C4A C4A, CD55
Artery_Aorta 395 3 1 VARS2 7 AGER, C4A, MICB, TAPBP AGER, C4A, MICB, TAPBP
Brain_Substantia_nigra 54 0 0 2
Cells_EBV-transformed_lymphocytes 112 0 0 3 C4A C4A
Pancreas 321 1 0 6 C4A, MICB C4A, FUT10, GRIA4, MICB
Brain_Cortex 170 1 1 LRRC37A2 4 C4A, MICB, PRSS3 C4A, MICB, PRSS3
Brain_Hippocampus 89 0 0 4 C4A C4A
Brain_Frontal_Cortex_BA9 117 1 1 LRRC37A2 4 C4A, MICB C4A, MICB
Artery_Tibial 531 5 1 C4A C4A 8 AGER, C4B, MICB, TAPBP AGER, C4A, C4B, MICB, TAPBP
Uterus 55 0 0 2
Adipose_Visceral_Omentum 341 6 3 LRRC37A2, MDH1, MICB MICB 5 AGER, C4A AGER, C4A, ICAM5, MICB
Artery_Coronary 130 2 2 C4A, LRRC37A2 C4A 4 C4A, MICB C4A, MICB
Colon_Transverse 247 2 2 C4A, LRRC37A2 C4A 5 C4A C4A
Stomach 208 0 0 6 AGER, C4A, MICB AGER, C4A, MICB
Vagina 45 1 1 LRRC37A2 2 MICB MICB
Heart_Atrial_Appendage 328 1 1 FOLH1 8 C4A, MICB, TAPBP C4A, ICAM5, MICB, TAPBP
Brain_Putamen_basal_ganglia 112 0 0 2
Brain_Spinal_cord_cervical_c-1 70 1 1 LRRC37A2 2
Skin_Not_Sun_Exposed_Suprapubic 432 7 3 C4A, CROT, LRRC37A2 C4A 4 C4A, C4B C4A, C4B, MICB
Testis 417 2 1 VARS2 6 AGER, C4B, MICB AGER, C4B, HAVCR2, MICB
Ovary 97 1 1 LRRC37A2 2 AGER AGER
Heart_Left_Ventricle 314 4 3 C4A, LRRC37A2, MICB C4A, MICB 6 C4A, TAPBP C4A, ICAM5, MICB, TAPBP
Cells_Transformed_fibroblasts 485 0 0 9 AGER, C4A, C4B, MICB, TAPBP AGER, C4A, C4B, ICAM5, MANBA, MICB, TAPBP
Brain_Cerebellar_Hemisphere 213 0 0 5 C4A, MICB C4A, MICB
Esophagus_Muscularis 477 7 1 C4A C4A 7 AGER, C4A, TAPBP AGER, C4A, FAM171B, MICB, TAPBP
Spleen 208 1 1 LRRC37A2 4 C4A, MICB C4A, DOCK9, MICB
Brain_Caudate_basal_ganglia 165 0 0 2 C4A C4A, PRSS3
Muscle_Skeletal 502 5 3 C4A, PILRA, RHOA C4A 9 MICB, TAPBP C4A, MICB, TAPBP
Brain_Cerebellum 329 2 2 C4A, LRRC37A2 C4A 7 AGER, MICB AGER, C4A, MANBA, MICB
Esophagus_Gastroesophageal_Junction 240 0 0 4 C4A, MICB C4A, MICB
Lung 486 4 2 C4A, LRRC37A2 C4A 6 C4A, MICB, TAPBP AGER, C4A, CST7, MICB, TAPBP
Thyroid 609 5 1 MICB MICB 12 C4A, C4B, MICB, TAPBP C4A, C4B, MICB, PAM, TAPBP, TFF3
Liver 127 1 1 C4A C4A 4 MICB C4A, FUT10, MICB
Brain_Amygdala 54 0 0 3 C4A C4A
Colon_Sigmoid 251 0 0 6 C4A, MICB, TAPBP C4A, MICB, TAPBP
Whole_Blood 439 2 2 LRRC37A2, MICB MICB 8 C4A, C4B C4A, C4B, MICB

8. gene expression as exposure while interval as outcome

Tissue proteins.n IV>3 Presso.genes All.n All.genes
Cage 1109 24 ASL, CPNE1, LYZ, NAAA, OAS1, PAM 93 AGRP, ALDOC, ARFIP1, B4GALT1, BIN1, BPI, BST1, CBR3, CCDC126, CCDC134, CCL23, CCL5, CD200R1, CD209, CD48, CHI3L2, CLEC11A, CLN5, COL18A1, CPNE1, CRISPLD2, CST7, ERAP2, ESAM, ESD, FAM177A1, FAM3B, FCER2, FCRL3, FCRL3, FCRL6, FSTL1, FUT8, GABARAPL2, GLCE, GLO1, GNLY, GNMT, GNPTG, GSTA1, GZMA, GZMB, HAVCR2, HBZ, HDHD2, HSP90B1, HTATIP2, IDUA, IGFLR1, IL12RB2, IL15RA, IL1RAP, IL27RA, KIR2DS2, LCP1, LGALS2, LILRA5, LILRB2, MAN1A2, MANBA, MFGE8, MTHFS, MTRF1L, NAGK, NCR3, NPTX1, NQO2, NUDT9, PCSK7, PLAU, PLD3, PLXNB2, PPIE, PTGDS, PTPN11, QDPR, RBP7, SERPINE2, SIGLEC12, SIGLEC9, SLAMF6, SNCA, SPATA20, SPINT2, SPOCK2, STX7, STX8, TAPBPL, TCN2, TNFSF14, TPI1, TXNRD1, IGFLR1
Gevadis 219 0 51 ARFIP1, B4GALT1, CBR1, CCDC126, CCDC134, CCL5, CD48, CHI3L1, CPA4, CPNE1, CTSS, DHX58, ERAP1, ERAP2, FCGR2A, FCRL3, GNMT, H6PD, HDHD2, HLA-DQA2, IDUA, IGFLR1, IL1RN, LAMC2, MAPK13, MFGE8, MICB, MTHFS, NAAA, NEO1, NME2, NMRAL1, NQO2, NTNG1, NUDT12, OAS1, PDGFRB, POGLUT1, POMGNT2, PPT1, QDPR, QSOX2, RGMB, SLAMF7, SPATA20, SPINT2, SWAP70, TAPBPL, TNFSF14, IGFLR1, UROS
Prostate 93 0 25 BPI, COLEC11, CPNE1, CRELD1, CTSB, DNAJB12, ERAP2, FAM20B, GPX7, GSTT2B, GSTT2B, LRRC15, MICB, MSMB, NFASC, NQO2, OAF, PLA2G2A, PPIE, PSG4, SARS2, SIGLEC12, SPATA20, TAPBPL, TDGF1
Nerve_Tibial 769 1 HLA-DQA2 145 ABO, ADAM23, APOE, ARFIP1, ARHGAP1, ARSB, ATP1B2, B3GAT3, B3GNT8, B4GALT6, BOC, BPI, CBLN1, CBR1, CBR3, CCL14, CCL23, CCL25, CD55, CD59, CHI3L1, CLEC12A, CLN5, COL18A1, COLEC11, CREB3L4, CRELD1, CRHBP, CST6, CTSB, CTSS, DEFB1, DHX58, DKK3, DNAJA4, EGFR, ERAP1, ERAP2, FAM3B, FAP, FAS, FCER2, FKBP7, FLRT2, FRZB, GLO1, GNLY, GNMT, GNPTG, GP1BA, GPX7, GRN, GSTM1, GSTO1, GSTT2B, GSTT2B, GXYLT1, H6PD, HDHD2, HP, HS6ST1, HTATIP2, IDUA, IGDCC4, IGF2R, IGSF8, IL11RA, IL17RB, IL18R1, ITIH5, KLK7, LAMC2, LGALS2, LGALS9, LILRA6, LILRB2, LMAN2L, LRRC15, LYZ, MANEA, MAPK3, MBL2, MFAP2, MGAT4C, MIA, MTHFS, MXRA8, NAAA, NAGK, NOV, NQO2, NTNG1, NUDT12, NUDT9, PCBD1, PCSK1, PDCD1LG2, PIANP, PLA2R1, PLAU, PLD3, PLXNA1, PLXNB2, POGLUT1, PPIE, PRDX1, PTGFRN, PTGR1, PTN, QDPR, RELT, RMDN1, RNASE2, RNASE4, RPN1, RSPO4, SAA1, SCARA5, SECTM1, SELL, SEMA3E, SEMA5A, SERPINF1, SIGLEC12, SIGLEC14, SIGLEC7, SMPDL3A, SPARCL1, SPATA20, SPINT2, STX8, TAPBP, TAPBPL, TCN2, TDGF1, TIE1, TNC, TNFSF12, TPSB2, TPST1, TPST2, TXNDC5, VIT, WISP1, XXYLT1
Minor_Salivary_Gland 60 0 18 CBR3, CLEC12A, CPNE1, CSGALNACT2, CTSS, ERAP2, FUT10, GPX7, GSTT2B, GSTT2B, HLA-DQA2, HMBS, NQO2, PPIE, PSG4, SIGLEC12, SPATA20, TAPBPL
Brain_Nucleus_accumbens_basal_ganglia 153 0 32 CHST9, COLEC11, CPNE1, CTSB, CXCL16, ERAP1, ERAP2, FAM20B, FAS, GNLY, GNMT, GPNMB, GSTM1, GSTT2B, GSTT2B, HTATIP2, IL18R1, IL1RL1, IL1RL2, MAPK13, NQO2, NUDT12, PPIE, PTGR1, RMDN1, SAT2, SPATA20, SPINK2, TAPBPL, TDGF1, TPSB2, UROS
Small_Intestine_Terminal_Ileum 97 0 27 ABO, CCL14, CCL25, CLEC12A, CPNE1, DHX58, ERAP1, ERAP2, GNMT, GPX7, GSTO1, GSTT2B, GSTT2B, KLK12, LRRC15, MTHFS, NAAA, NQO2, PDCD5, PMEL, POGLUT1, PPIE, RSPO4, SIGLEC12, SPATA20, TAPBPL, TDGF1
Pituitary 212 0 45 ABO, ADAMTS13, ARHGAP1, BPI, CLEC12A, COL6A1, COLEC11, CPNE1, CTSB, CTSS, DCBLD2, DSG2, EGF, ERAP1, ERAP2, FAM20B, FAM3B, FUT10, GGH, GLO1, GNMT, GPX7, GSTT2B, GSTT2B, IGSF8, IL11RA, KDELC2, MXRA7, NAAA, NMRAL1, NQO2, PMEL, POGLUT1, PPIE, PTGR1, RMDN1, SCG3, SEMA4D, SIGLEC12, SIGLEC14, SPATA20, TAPBPL, TDGF1, UROS, XXYLT1
Adipose_Subcutaneous 590 1 HLA-DQA2 119 ABO, ADAMTS13, ARFIP1, ARHGAP1, ARSB, ART3, ATP1B2, CAT, CBR1, CBR3, CCL14, CCL23, CD200R1, CD59, CFH, CHI3L1, CHIT1, CHST15, CLEC12A, CLN5, CPXM1, CPZ, CREB3L4, CRELD1, CRHBP, CTSB, DCBLD2, DEFB1, DHX58, DKK3, ENTPD5, ERAP1, ERAP2, FAH, FAM177A1, FAM20B, FAM3B, FAS, FCER2, FCRL3, FKBP7, FRZB, FUT10, GNLY, GNMT, GNPTG, GRN, GSTM1, GSTT2B, GSTT2B, GXYLT1, HBZ, HDHD2, HINT1, HTATIP2, ICAM5, IDUA, IFNAR1, IGDCC4, IGF2R, IGSF8, IL11RA, IL17RA, IL17RB, IL27RA, ISG15, ISLR2, LAMC2, LEPR, LGALS2, LILRB2, LRRC15, LYZ, MFAP2, MRC2, MTHFS, NAAA, NAGPA, NCAM2, NQO2, NTNG1, NUDT12, OAS1, PCDH9, PDCD1LG2, PLA2R1, PLXNA1, PMEL, POGLUT1, PPIE, PRDX1, PSG4, PTGDS, PTGR1, QDPR, RET, RMDN1, RNASE6, RPN1, SCARA5, SECTM1, SEMA3E, SERPINF1, SIGLEC12, SIGLEC14, SMPDL3A, SPARCL1, SPATA20, SPINK2, SPINT2, SPOCK2, STX8, TAPBP, TAPBPL, TDGF1, TIE1, TNFSF12, TXNDC5, VIT
Skin_Sun_Exposed_Lower_leg 654 1 MICB 119 ABO, ACP5, ADAMTS13, ARFIP1, ARHGAP1, ARSB, B3GAT3, CBR3, CCL14, CCL23, CD59, CLEC12A, CLN5, COLEC11, CPXM1, CRELD1, CRHBP, CST7, CTSB, DHX58, DKK3, DNAJB12, DPT, EPHA1, ERAP1, ERAP2, FAM177A1, FAM20B, FAM213A, FAM3B, FAS, FCER2, FCGR2A, FCGR3B, FKBP7, FUT10, GABARAPL2, GNLY, GNMT, GP1BA, GPNMB, GPX7, GSTA1, GSTT2B, GSTT2B, GXYLT1, HBZ, ICAM5, ICOSLG, IDUA, IGFLR1, IL11RA, IL17RA, IL18R1, ISLR2, KLK7, KLK8, LAMC2, LGALS9, LIFR, LILRA6, LILRB2, LIPN, LMAN2L, LYZ, MANEA, MAPK13, MAPK3, MFAP2, MRC2, MSMB, MTHFS, NAAA, NAGK, NCAM1, GPNMB, NOV, NPTX1, NQO2, NTNG1, NUDT12, OAF, OAS1, OBP2B, PAM, PDCD1LG2, PLXNB2, POGLUT1, PPIE, PRDX1, PSAPL1, PSG4, PTGR1, RARRES1, RMDN1, RNASE4, RPN1, SECTM1, SERPINA12, SERPINF1, SIGLEC12, SIGLEC14, SMPDL3A, SPARCL1, SPATA20, SPINK2, SPINK5, SPINT3, ST3GAL6, STX8, TAPBP, TAPBPL, TCN2, TDGF1, TIE1, TXNDC5, IGFLR1, WFIKKN2, XXYLT1
Esophagus_Mucosa 601 1 MICB 106 ADAM23, ADAMTS13, ARFIP1, ARL3, B3GAT3, B4GALT1, CA3, CAT, CBLN1, CBR3, CCDC126, CCL14, CCL23, CLEC12A, CNTN2, COLEC11, CPNE1, CRELD1, DHX58, DKK3, DNAJB12, ENTPD5, EPHA1, EPHB6, ERAP1, ERAP2, FAM177A1, FAM213A, FAM3B, FCRL3, FGFR3, FRZB, FUT3, GFRA2, GNLY, GP1BA, GPX7, GSTA1, GSTT2B, GSTT2B, HTATIP2, IDUA, IGFLR1, IL11RA, IL15RA, IL17RA, IL17RB, IL27RA, ISLR2, KLK11, KLK12, KLK7, LGALS2, LGALS9, LILRB1, LMAN2L, LRRC15, LSAMP, LTF, LYZ, MAN1A2, MANEA, MAPK13, MFGE8, MTHFS, MXRA8, NAAA, NAGK, NDST1, NMRAL1, NSF, NTNG1, NUDT12, OAF, OAS1, PCBD1, PENK, PIANP, PLA2R1, POGLUT1, POMGNT2, PPIE, PSAPL1, PSG4, PTGFRN, PTN, QDPR, RGMB, RMDN1, SECTM1, SEMA3E, SERPINF1, SIGLEC12, SIGLEC14, SLAMF7, SMPDL3A, SPARCL1, SPATA20, SPINK6, STX8, TAPBP, TAPBPL, TDGF1, IGFLR1, UGT1A6, XXYLT1
Brain_Hypothalamus 90 0 25 CHST9, COLEC11, CPNE1, DLD, ERAP1, ERAP2, GNLY, GNMT, GPNMB, GSTT2B, GSTT2B, IL18R1, IL1RL1, LAMC2, LTF, MAPK13, PPIE, PTGR1, SIGLEC12, SIGLEC14, SPATA20, TAPBPL, TDGF1, TPSB2, UROS
Breast_Mammary_Tissue 285 0 68 ABO, ADAMTS13, ARFIP1, ARSB, BPI, CAT, CBR1, CBR3, CCL14, CCL23, CLEC12A, CLN5, CPNE1, CRELD1, CTSB, CTSS, DEFB1, DHX58, ERAP1, ERAP2, FAM20B, FAS, FCER2, FKBP7, FUT10, GPX7, GSTM1, GSTT2B, GSTT2B, HBZ, HDHD2, HTATIP2, IDUA, IGDCC4, IGF2R, IL17RA, IL27RA, LILRA6, LYZ, MANEA, MDH1, MICB, MRC2, MTHFS, NAAA, NAGPA, NQO2, NTNG1, NUDT12, PDCD1LG2, PMEL, POGLUT1, PPIE, PSG4, PTGR1, RMDN1, SECTM1, SEMA3E, SIGLEC12, SIGLEC14, SPARCL1, SPATA20, SPOCK2, STX8, TAPBPL, TDGF1, TIE1, UROS
Brain_Anterior_cingulate_cortex_BA24 115 0 26 ABO, CNDP2, COLEC11, CPNE1, ERAP1, ERAP2, FAS, GNMT, GPNMB, GSTT2B, GSTT2B, HTATIP2, IL18R1, IL1RL1, LAMC2, MICB, NAAA, NMRAL1, NUDT12, PTGR1, RMDN1, SPATA20, TAPBPL, TDGF1, TPSB2, UROS
Adrenal_Gland 267 0 63 ABO, AKR1C1, APMAP, ARFIP1, ATP1B2, BPI, CD55, CD59, CLEC12A, CPNE1, CRELD1, CRHBP, CTSS, DAPK2, DSC2, EPHB2, ERAP1, ERAP2, FAM177A1, FAM3B, FCN2, FSTL4, FUT10, GNMT, GPX7, GSTA1, GSTT2B, GSTT2B, HLA-DQA2, IGDCC4, IL11RA, LILRA6, LRRC15, LYZ, MANEA, MFAP2, MFGE8, MICB, MTHFS, MXRA7, NAAA, NDST1, NQO2, PDCD1LG2, PLA2R1, POGLUT1, PPIE, PPT1, PSG4, QDPR, RMDN1, RSPO4, SIGLEC12, SIGLEC14, SIGLEC7, SPATA20, SPOCK2, STX8, TAPBPL, TDGF1, TFF3, TNXB, UROS
Artery_Aorta 462 1 MICB 93 ADAM23, ADAMTS13, ARFIP1, ARL3, ARSB, B3GNT8, BIN1, BPI, CAT, CBR3, CCL23, CD109, CD59, CLEC12A, CREB3L4, CRELD1, CST6, CTSB, CTSS, DEFB1, DHX58, DKK3, DPT, ENPP5, ERAP2, F10, FAM3B, FGFR3, FKBP7, FUT10, GLO1, GNLY, GNMT, GNPTG, GPC5, GPX7, GRN, GSTT2B, GSTT2B, GXYLT1, H6PD, HAPLN1, HTATIP2, IDUA, IGDCC4, IGFLR1, IL17RA, LAMC2, LGALS2, LILRB1, LMAN2L, LYZ, MANEA, MFAP2, MICB, MTHFS, NAAA, NCAM1, NFASC, NOV, NQO2, NUDT12, PCBD1, PCOLCE2, PCSK7, PDCD1LG2, PIANP, POGLUT1, PPIE, PRDX1, PTGDS, PTGR1, QSOX2, RMDN1, RPN1, RSPO4, SIGLEC12, SIGLEC14, SMOC1, SPATA20, SPINK2, SPINT2, ST3GAL6, TAPBP, TAPBPL, TCN2, TIMP4, TNFSF12, TPSB2, IGFLR1, UNC5C, VWC2, XXYLT1
Brain_Substantia_nigra 64 0 18 ARFIP1, CHST9, COLEC11, CPNE1, ERAP1, ERAP2, GNLY, GNMT, GSTT2B, GSTT2B, HLA-DQA2, LTF, PPIE, SIGLEC14, SPATA20, TDGF1, TPSB2, UROS
Cells_EBV-transformed_lymphocytes 124 0 34 ARFIP1, CBR1, CCDC126, CCL5, CNDP2, CPA4, CPNE1, DHX58, ENPP7, ERAP1, ERAP2, FUT10, H6PD, HDHD2, IGFLR1, LILRB1, MAPK3, MTHFS, NAGK, NEO1, NMRAL1, NUDT12, POGLUT1, POMGNT2, PPIE, PPT1, QDPR, SIGLEC14, SPATA20, SPINT2, SWAP70, TAPBPL, IGFLR1, UROS
Pancreas 358 0 74 ABO, ACP5, AKR1C1, ARFIP1, ARHGAP1, CBLN1, CD59, CLEC12A, CLN5, CLPS, CPNE1, CREG1, CTRB1, CTSB, CTSS, CXCL11, DEFB1, EGF, ENPP5, ERAP1, ERAP2, FAM3B, FUT10, GNLY, GPX7, GSTO1, GSTT2B, GSTT2B, H6PD, HTATIP2, IDUA, IGDCC4, IGFLR1, IL17RA, LRPAP1, LYZ, MANEA, MAPK13, MATN4, MICB, NAAA, NAGK, NQO2, NUDT12, NUDT9, OAF, PDCD1LG2, PDCD5, PLXNC1, POGLUT1, POMGNT2, PPIE, PSG4, PTGR1, QDPR, RMDN1, ROR2, RPN1, RSPO4, SFRP1, SIGLEC12, SIGLEC14, SIRPA, SMPDL3A, SPATA20, SPINK2, SPOCK2, ST3GAL6, STX8, TAPBPL, TPSB2, IGFLR1, VTN, XXYLT1
Brain_Cortex 200 0 43 ABO, ADAMTS13, AKR1C1, ARFIP1, CBR3, CD59, CHIT1, CNDP2, COLEC11, CPNE1, DLD, ENPP5, ERAP1, ERAP2, FAS, GNMT, GPNMB, GSTT2B, GSTT2B, HTATIP2, IGSF8, IL18R1, IL1RL1, LAMC2, MAPK3, MICB, NAAA, NMRAL1, OAF, OLA1, POGLUT1, POMGNT2, PPIE, PRSS3, PTGR1, RMDN1, SIGLEC14, SPATA20, SPINK2, ST3GAL1, TAPBPL, TDGF1, TPSB2
Brain_Hippocampus 101 0 26 ADAMTS13, COLEC11, CPNE1, CXCL16, ERAP1, ERAP2, FAS, GNLY, GNMT, GPNMB, GSTT2B, GSTT2B, HTATIP2, IL18R1, IL1RL1, NMRAL1, NQO2, PPIE, RMDN1, SIGLEC14, SPATA20, TAPBPL, TDGF1, THBS2, TPSB2, UROS
Brain_Frontal_Cortex_BA9 146 0 34 ABO, CD59, COLEC11, CPNE1, DAPK2, ENPP5, ERAP1, ERAP2, FAM213A, FAS, GNMT, GPNMB, GSTA1, GSTT2B, GSTT2B, IL18R1, IL1RL1, LAMC2, MAPK3, MICB, NAAA, NMRAL1, NUDT12, PCOLCE2, POMGNT2, PPIE, PTGR1, RARRES1, SIGLEC14, SPATA20, TAPBPL, TDGF1, TPSB2, UROS
Artery_Tibial 627 0 112 ACP1, ADAM23, ADAMTS13, ARFIP1, ARL3, ARSB, B3GAT3, BPI, C1QTNF3, CAT, CBR1, CBR3, CCL14, CCL23, CD109, CD200R1, CD55, CD59, CHI3L1, CLEC12A, COL18A1, COLEC11, CREB3L4, CRELD1, CST6, DCBLD2, DEFB1, DHX58, DKK3, DNAJA4, ENPP5, ERAP2, F10, FAM20B, FAP, FKBP7, FLRT2, FUT10, GLO1, GNMT, GNPTG, GRN, GSTT2B, GSTT2B, GXYLT1, H6PD, HAPLN1, HDHD2, HTATIP2, IDUA, IFNAR1, IGDCC4, IGFLR1, IGSF8, IL11RA, IL17RB, IL27RA, IL6R, ISG15, ITIH5, LGALS2, LMAN2L, LRRC15, LYZ, MANEA, MFAP2, MTHFS, NAAA, NAGK, NCAM1, NCAM2, NFASC, NOV, NRXN3, NTNG1, NUDT12, PCSK1, PDCD1LG2, PDGFRB, PIANP, PMEL, POGLUT1, PPIE, PPT1, PRDX1, PTGDS, PTGR1, QDPR, RGMA, RMDN1, RPN1, SAA1, SEC11C, SERPINF1, SIGLEC12, SIGLEC14, SMOC1, SPARCL1, SPATA20, SPINK2, SPINT2, ST3GAL6, STX8, SWAP70, TAPBP, TAPBPL, TCN2, TIMP4, TNFSF12, TPSB2, IGFLR1, XXYLT1
Uterus 69 0 23 ARFIP1, BPI, CLEC12A, CPNE1, CRELD1, ERAP2, FUT10, GPX7, GSTT2B, GSTT2B, HTATIP2, MICB, MTHFS, NAAA, NQO2, PDCD1LG2, POGLUT1, PPIE, RSPO4, SIGLEC12, SPATA20, TAPBPL, TDGF1
Adipose_Visceral_Omentum 401 0 94 ABO, ARFIP1, ARHGAP1, BPI, CAT, CBR1, CBR3, CCL14, CCL23, CD59, CHIT1, CHST11, CLEC12A, CLN5, CPXM1, CRELD1, CTSB, CTSS, DEFB1, DHX58, ERAP1, ERAP2, FAM20B, FAM3B, FAS, FCER2, FGFR3, FKBP7, FUT10, GNMT, GPX7, GSTM1, GSTT2B, GSTT2B, GXYLT1, HDHD2, HTATIP2, ICAM5, IDUA, IFNAR1, IGDCC4, IL15RA, IL17RA, IL18R1, IL27RA, ISLR2, LAMC2, LEPR, LGALS9, LILRA6, LIPN, LYZ, MAN1A2, MANEA, MFAP2, MTHFS, NAAA, NAGK, NDST1, NMRAL1, NQO2, NTNG1, NUDT12, PDCD1LG2, PDCD5, PENK, PLD3, PLXNA1, PMEL, POGLUT1, PPIE, PTGDS, PTGR1, QDPR, RBP4, RMDN1, RPN1, RSPO4, SECTM1, SEMA3E, SIGLEC12, SIGLEC14, SIGLEC7, SPARCL1, SPATA20, SPOCK2, STX8, TAPBPL, TAX1BP3, TDGF1, TIE1, TIMP4, TXNDC5, UROS
Artery_Coronary 154 0 42 ABO, ARFIP1, BPI, CFH, CLEC12A, CPNE1, CRELD1, DHX58, DKK3, ERAP1, ERAP2, FGFR3, FKBP7, FUT10, GGH, GNMT, GPX7, GSTT2B, GSTT2B, HTATIP2, IL17RA, MFAP2, MICB, MTHFS, NAAA, NQO2, PDCD1LG2, POGLUT1, PPIE, PTGR1, RMDN1, SIGLEC12, SIGLEC14, SMOC1, SPATA20, SPINK2, TAPBP, TAPBPL, TDGF1, TXNDC5, UROS, XXYLT1
Colon_Transverse 301 0 74 ABO, ACYP2, ADH4, AKR1C1, APMAP, ARFIP1, BPI, CCL14, CLEC12A, CNTN2, CPNE1, CPXM1, CRELD1, CTSB, CTSS, DHX58, EGF, ENTPD5, ERAP1, ERAP2, FAM3B, FKBP7, FUT10, GFRA2, GNLY, GNMT, GPX7, GSTA1, GSTO1, GSTT2B, GSTT2B, H6PD, HAVCR1, IDUA, IL11RA, IL17RA, IL18R1, IL6R, LILRA6, LRRC15, LYZ, MICB, MTHFS, NAAA, NAGK, NDST1, NFASC, NID2, NOV, NQO1, NQO2, NTNG1, NUDT12, OAF, PDCD5, PLA2R1, PMEL, POGLUT1, PPIE, PPT1, PTGR1, QDPR, RSPO4, SECTM1, SIGLEC12, SIGLEC14, SORBS3, SPATA20, TAPBPL, TDGF1, TPSB2, UROS, VWC2, XXYLT1
Stomach 241 0 61 ABO, ARFIP1, ARHGAP1, ASAH2, B3GNT8, BPI, CBLN1, CCL14, CD59, CLEC12A, CLN5, COCH, CPNE1, CTSS, DEFB1, DHX58, ENTPD5, ERAP1, ERAP2, FAM3B, FAS, FUT10, GFRA2, GNLY, GPX7, GSTA1, GSTT2B, GSTT2B, IDUA, IL11RA, IL17RD, KDELC2, LRRC15, MAPK13, MICB, MSMB, NAAA, NMRAL1, NQO2, NTNG1, OAF, PCBD1, PDCD1LG2, POGLUT1, PPIE, PPT1, QDPR, RSPO4, SAT2, SIGLEC12, SIGLEC14, SPATA20, SPINK2, SPINT2, ST3GAL6, STX8, TAPBPL, TDGF1, TPSB2, UROS, XXYLT1
Vagina 62 0 24 ABO, BPI, CLEC12A, CPNE1, CRELD1, DHX58, ERAP1, ERAP2, FUT10, GNMT, GPX7, GSTT2B, GSTT2B, KLK12, MICB, MTHFS, NAAA, NQO2, PPIE, PSG4, SIGLEC12, SPATA20, TAPBPL, TDGF1
Heart_Atrial_Appendage 366 0 78 ACP1, ADAM23, AKR1C1, ARFIP1, BPI, CAT, CBR1, CD200R1, CD55, CD59, CHST9, CLEC12A, CLN5, CNTNAP2, CRELD1, CRHBP, CTSB, CTSS, DEFB1, DHX58, ERAP1, ERAP2, FAM3B, FKBP7, FLRT2, FRZB, FUT10, GFRA2, GNLY, GNMT, GNPTG, GPNMB, GRAMD1C, GRN, GSTT2B, GSTT2B, GXYLT1, H6PD, HTATIP2, ICAM5, ICOSLG, IDUA, IGF2R, IL17RA, LAMC2, LCN1, LILRB1, LRRC15, LYZ, MANEA, MFAP2, MFGE8, MICB, MTHFS, NAAA, NMRAL1, NUDT12, OAF, PCSK1, PDCD1LG2, PENK, PIANP, PLA2R1, PLAU, POGLUT1, PPIE, PTGFRN, PTGR1, SIGLEC12, SIGLEC14, SPATA20, SPON1, STX7, STX8, TAPBP, TAPBPL, TCN2, WISP1
Brain_Putamen_basal_ganglia 134 0 26 CNDP2, COLEC11, CPNE1, ERAP1, ERAP2, FAS, GNMT, GPNMB, GSTT2B, GSTT2B, HLA-DQA2, HTATIP2, IL18R1, IL1RL1, NMRAL1, NQO2, OAF, POGLUT1, POMGNT2, PPIE, RMDN1, SPATA20, SPINK2, TDGF1, TPSB2, UROS
Brain_Spinal_cord_cervical_c-1 82 0 19 AKR1C1, ARFIP1, B3GAT3, CPNE1, ENPP5, ERAP1, ERAP2, FSTL1, FUT10, GSTT2B, GSTT2B, HLA-DQA2, IL18R1, LTF, MXRA7, PPIE, SIGLEC14, SPATA20, TDGF1
Skin_Not_Sun_Exposed_Suprapubic 505 3 CPNE1, MICB 103 ABO, ACP5, ADAMTS13, ARFIP1, ARSB, B3GAT3, CBR3, CCL14, CCL23, CD109, CD59, CLEC12A, CLN5, CNTN2, COLEC11, CPNE1, CPXM1, CRELD1, CRHBP, CST7, CTSB, CTSS, DHX58, DKK3, ERAP1, ERAP2, FAM177A1, FAM20B, FAM213A, FAS, FCER2, FCGR3B, FUT10, GNLY, GNMT, GP1BA, GPNMB, GPX7, GSTA1, GSTT2B, GSTT2B, H6PD, HBZ, ICOSLG, IDUA, IFNAR1, IGFLR1, IL11RA, IL17RA, IL18R1, IL1RL2, ISLR2, KLK7, LILRB2, LMAN2L, LYZ, MAN1A2, MAPK13, MFAP2, MSMB, MTHFS, NAAA, NAGK, NCAM1, GPNMB, NPTX1, NQO2, NTNG1, NUDT12, NUDT9, OAF, OAS1, OBP2B, PDCD1LG2, POGLUT1, PPIE, PRDX1, PSAPL1, PSG4, PTGR1, RARRES1, RMDN1, RPN1, SERPINA12, SIGLEC12, SIGLEC14, SMPDL3A, SORBS3, SPARCL1, SPATA20, SPINT1, SPINT3, ST3GAL6, STX8, TAPBPL, TCN2, TDGF1, TIE1, TPSB2, TPST2, IGFLR1, VWC2, XXYLT1
Testis 473 0 84 A4GALT, ABO, AKR1C1, APOE, CAT, CBR1, CCL25, CD59, CHL1, CLEC12A, CLN5, CNTN4, CPNE1, CPNE1, CRELD1, CTSS, DHX58, DUSP13, ERAP1, ERAP2, FAM177A1, FAM213A, FUT10, FUT3, GALNT16, GFRA2, GGH, GNMT, GPNMB, GPX7, GSTT2B, GSTT2B, HAVCR1, HAVCR2, IDUA, IFNAR1, IGLL1, IL15RA, IL17RA, IL1RAP, IL6R, IL7R, IMPDH1, LAMC2, LIFR, LYZ, MANEA, MAPK13, MFGE8, MICB, MTRF1L, NAAA, NDNF, NID2, GPNMB, NPW, NQO1, NQO2, NUDT9, PCBD1, PCDH9, PCOLCE2, PIANP, PPIE, PRCP, QDPR, RMDN1, RNASE4, RPN1, SCG3, SEMA5A, SERPINF1, SIGLEC14, SIRPA, SMPDL3A, SPATA20, SPON1, STX8, TAPBPL, TDGF1, THBS2, TMEM190, TNC, TPSB2
Ovary 120 0 31 ABO, ADAMTS13, AKR1C1, APOE, ASPH, BPI, CD59, CLEC12A, CLMP, CPNE1, CRELD1, ERAP2, GNMT, GPX7, GSTT2B, GSTT2B, HTATIP2, MTHFS, NAAA, PDCD1LG2, PIANP, PPIE, PTGDS, PTGR1, RSPO4, SPATA20, SPINK2, SPOCK2, SPON1, TAPBPL, TDGF1
Heart_Left_Ventricle 345 1 HLA-DQA2 75 ADAMTS13, ARFIP1, BPI, CACNA2D3, CAT, CBLN1, CBR1, CD59, CHST9, CLEC12A, CLN5, COL15A1, CRELD1, CTSB, CTSS, DEFB1, DHX58, DLK1, ERAP1, ERAP2, F10, FAM177A1, FAM213A, FAS, FGFR3, FKBP7, FUT10, GFRA2, GNLY, GNMT, GPNMB, GPX7, GSTT2B, GSTT2B, H6PD, HINT1, HLA-DQA2, HTATIP2, ICAM5, IDUA, IGFBP3, IL17RA, IL27RA, LAMC2, LGALS2, LYZ, MFAP2, MTHFS, NAAA, NDST1, NFU1, NQO2, OBP2B, PDCD1LG2, PENK, PIANP, POGLUT1, PPIE, PRDX1, PTGR1, RSPO4, SEMA3C, SIGLEC12, SIGLEC14, SNCA, SPATA20, SPOCK2, SPON1, STX7, TAPBP, TAPBPL, TDGF1, TIE1, TPSB2, WISP1
Cells_Transformed_fibroblasts 565 0 109 ADAM23, ADAMTS13, ADH4, ARFIP1, BST1, CAT, CBR1, CBR3, CD55, CD59, CHI3L1, CLEC12A, CLN5, COLEC11, COLGALT1, CPA4, CPNE1, CPXM1, CREB3L4, CRELD1, CST6, CTSB, CTSS, DHX58, DKK3, ENPP5, ERAP1, ERAP2, FAM177A1, FAP, FKBP7, FUT10, GNMT, GNPTG, GP1BA, GP5, GPX7, GRN, GSTM1, GSTT2B, GSTT2B, GXYLT1, H6PD, HAVCR1, HDHD2, HSP90B1, HTATIP2, ICAM5, IFNAR1, IGDCC4, IGFBP7, IGFLR1, IL12RB2, IL15RA, IL17RA, IL17RB, IL27RA, LMAN2L, LRRC15, MANBA, MANEA, MAPK3, MFAP2, MFGE8, MICB, MTHFS, NAAA, NAGK, NCAM1, NEO1, NFASC, NFU1, NMRAL1, NTNG1, NUDT12, NUDT9, OAF, PCSK7, PDCD1LG2, PENK, PF4V1, PLA2R1, PLXNA1, PMEL, POGLUT1, POMGNT2, PPIE, PPT1, PRDX1, PSG4, PSG4, PTGR1, QDPR, QPCT, QSOX2, RMDN1, SAA1, SECTM1, SERPINF1, SIRPA, SMAP1, SPATA20, TAPBP, TAPBPL, TCN2, TNFAIP6, TNFSF12, IGFLR1, XXYLT1
Brain_Cerebellar_Hemisphere 242 0 44 AKR1C1, ART3, B3GNT8, CA3, CD209, CD274, CNDP2, COL11A2, COL6A1, COLEC11, CPNE1, CST6, ENPP5, ERAP2, GALNT16, GNLY, GNMT, GPNMB, GSTM1, GSTT2B, GSTT2B, H6PD, HLA-DQA2, IGSF8, IL11RA, IL18R1, IL1RL1, LAMC2, LRP8, MANEA, MANSC4, NAAA, NMRAL1, PAM, POGLUT1, PPIE, RARRES1, RMDN1, SCG3, SIGLEC14, SPOCK2, TAPBPL, TDGF1, UROS
Esophagus_Muscularis 565 0 112 ABO, ARFIP1, B3GAT3, B3GNT8, B4GALT6, BIN1, BPI, CAT, CBLN1, CBR1, CBR3, CCL14, CCL23, CD55, CD59, CFH, CHI3L1, CLEC12A, CLN5, COCH, COLEC11, COLGALT1, CPNE1, CREB3L4, CRELD1, CRHBP, CTSB, CXCL16, DEFB1, DHX58, DKK3, DLL1, EMILIN3, ERAP1, ERAP2, ESD, FAM177A1, FAM3B, FAS, FKBP7, FUT10, GALNT16, GFRA2, GGH, GNLY, GNMT, GNPTG, GP1BA, GPX7, GRN, GSTO1, GSTT2B, GSTT2B, GXYLT1, H6PD, HDHD2, HTATIP2, IDUA, IFNAR1, IGDCC4, IGF2R, IGSF8, IL17RA, LAMC2, LGALS9, LILRA6, LILRB1, LMAN2L, LRRC15, LYZ, MANEA, MFAP2, MTHFS, NAAA, NAGK, NFASC, NMRAL1, NOV, NQO2, NRXN3, NTNG1, NUDT12, OAF, PDCD1LG2, PIANP, PLXNB2, POGLUT1, PPIE, PRDX1, PTGR1, QDPR, RGMB, RMDN1, RPN1, SECTM1, SEMA3E, SIGLEC12, SIGLEC14, SMOC1, SPATA20, SPOCK2, STX8, TAPBP, TAPBPL, TCN2, TDGF1, TIE1, TPSB2, TPST1, TPST2, VTN, XXYLT1
Spleen 241 0 61 ADAMTS13, ADH4, ARFIP1, CCDC126, CD59, CLEC12A, CNTN2, CPNE1, CRELD1, ENPP7, ERAP1, ERAP2, FABP4, FAM3B, FCRL3, GNLY, GNMT, GPX7, GSTT2B, GSTT2B, IGFLR1, IGSF8, IL11RA, IL15RA, IL17RB, KDELC2, LGALS2, LRIG3, LILRA6, LIPN, LRIG3, LRRC15, LYZ, MANBA, MANEA, MFAP2, MFGE8, MICB, MTHFS, NAGK, NQO2, NTNG1, NUDT12, PDCD1LG2, PF4V1, POGLUT1, PPIE, PTGR1, QDPR, RMDN1, RNASE6, RSPO4, SCARA5, SIGLEC12, SIGLEC14, SPATA20, TAPBPL, TDGF1, TPST2, IGFLR1, UROS
Brain_Caudate_basal_ganglia 193 0 38 ADAMTS13, B3GAT3, CNDP2, COLEC11, CPNE1, CTSS, DLD, ERAP1, ERAP2, FAM213A, FAS, GNLY, GNMT, GPNMB, GSTT2B, GSTT2B, HTATIP2, IGFBP7, IL18R1, IL1RL1, LAMC2, LYZ, NMRAL1, NQO2, POGLUT1, POMGNT2, PPIE, PTGR1, RMDN1, SCG3, SELL, SIGLEC14, SPATA20, TAPBPL, TDGF1, TNFRSF17, TPSB2, VTN
Muscle_Skeletal 572 1 HLA-DQA2 103 ACP1, ACYP2, ADAM23, ADAMTS13, ANGPTL1, APOM, ARHGAP1, B4GALT1, B4GALT6, CA3, CACNA2D3, CAT, CBLN1, CCL14, CCL23, CD59, CHI3L1, CHL1, CLEC12A, CNP, COL15A1, COLEC11, CPNE1, CREB3L4, CRHBP, CTSS, DEFB1, DHX58, DKK3, ENPP5, ERAP1, ERAP2, ESM1, EVL, FAH, FAS, FGF7, FGFR3, FKBP7, FRZB, FUT10, GLO1, GNLY, GNMT, GSTM1, GSTT2B, GSTT2B, H6PD, HS6ST1, HTATIP2, IDUA, IGDCC4, IGF2R, IL15RA, IL17RA, IL18R1, IL27RA, LILRA6, LMAN2L, LYZ, MANEA, MAPK3, MFAP2, MFGE8, MICB, MTHFS, MXRA7, NAAA, NCAM1, NFU1, NQO2, NUDT12, NUDT9, PCBD1, PDCD1LG2, PLXNB2, PMEL, POGLUT1, PPIE, PTGR1, PTPRU, RGMB, RMDN1, RPN1, RSPO4, SECTM1, SEMA3C, SEMA4D, SERPINF1, SIGLEC14, SPARCL1, SPATA20, SPOCK2, STX7, STX8, TAPBP, TAPBPL, TCN2, TDGF1, TIE1, TNFAIP6, VIT, WISP1
Brain_Cerebellum 369 0 53 ADAMTS13, AKR1C1, ARFIP1, ART3, B3GAT3, B3GNT8, C1QTNF3, CBR1, CD209, CD274, COL11A2, COL6A1, CPNE1, CST6, CTSS, CXCL16, DEFB1, ENPP5, ERAP1, ERAP2, GALNT16, GNLY, GNMT, GPNMB, GSTM1, GSTT2B, GSTT2B, H6PD, IFNAR1, IGSF8, IL11RA, IL17RB, IL18R1, IL1RL1, LAMC2, LRP8, MANBA, MANEA, NAAA, PAM, PDCD1LG2, POGLUT1, PPIE, PTGFRN, QSOX2, RARRES1, RMDN1, SCG3, SIGLEC9, SPATA20, SPOCK2, TAPBPL, TDGF1
Esophagus_Gastroesophageal_Junction 283 0 70 ABO, ACYP2, ARFIP1, BPI, CBR1, CBR3, CCL14, CD59, CLEC12A, CLN5, CNTN2, COLEC11, CPNE1, CRELD1, CRHBP, CST6, CTSB, CTSS, DEFB1, DHX58, DKK3, EMILIN3, ERAP1, ERAP2, FAM3B, FAS, FGFR3, FUT10, GFRA2, GLO1, GNLY, GNMT, GPX7, GSTT2B, GSTT2B, H6PD, HLA-DQA2, HTATIP2, IGF2R, IL17RA, LAMC2, LRRC15, MANEA, MICB, MTHFS, NAAA, NFASC, NMRAL1, NOV, NQO2, NTNG1, OAF, PDCD1LG2, PDCD5, PLA2R1, POGLUT1, PPIE, PPT1, PRDX1, PTGR1, RGMB, RMDN1, RPN1, SEMA3E, SIGLEC12, SIGLEC14, SPATA20, TAPBPL, TDGF1, TIE1
Lung 558 0 121 ABO, AGER, AKR1C1, ARFIP1, ARHGAP1, ARSB, ART3, ATP1B2, B3GNT8, B4GALT6, BIN1, CBR1, CCDC134, CCL14, CCL15, CD59, CHI3L1, CHIT1, CLEC12A, COL11A2, COLEC10, COLEC11, CPNE1, CPZ, CREB3L4, CRELD1, CTSB, CTSS, DEFB1, DHX58, ENPP5, ENPP7, ERAP1, ERAP2, F10, FAM177A1, FAM3B, FAS, FCER2, FCRL3, FKBP7, FUT10, FUT8, GNLY, GNMT, GNPTG, GPX7, GSTA1, GSTM1, GSTT2B, GSTT2B, H6PD, HAPLN1, HBZ, HDHD2, HTATIP2, ICAM5, IDUA, IGDCC4, IGFLR1, IGSF8, IL11RA, IL17RA, IL17RD, IL18R1, IL1RL1, ISLR2, LGALS2, LGALS9, LILRB1, LILRB2, LIPN, LRRC15, LYZ, MANEA, MFAP2, MFGE8, MRC2, MTHFS, NAAA, NAGK, NDST1, NMRAL1, NOV, NPW, NTNG1, NUDT12, OAF, PDCD1LG2, PDCD5, PEX14, PF4V1, PIANP, PLD3, PMEL, POGLUT1, PPIE, PTGR1, QDPR, RET, RMDN1, RNASE4, RPN1, RSPO4, SECTM1, SEMA4D, SIGLEC12, SIGLEC14, SPATA20, SPINK6, STX8, TAPBP, TAPBPL, TAX1BP3, TDGF1, TIE1, TMEM190, TMEM2, TPSB2, IGFLR1, XXYLT1
Thyroid 702 0 112 ABO, ADAM23, ADAMTS13, ARFIP1, ATP1B2, B3GAT3, B4GALT6, BPI, CA3, CACNA2D3, CCL14, CD200R1, CD59, CDH5, CHI3L1, CHI3L2, CHST15, CLEC12A, CLN5, CNTN2, COCH, CPZ, CREB3L4, CST6, CTSS, CXCL16, DEFB1, DHX58, DKK3, DLD, DLK2, DNAJB12, ENDOU, ENPP5, EPHA1, EPHB6, ERAP1, ERAP2, ESD, F10, FAM213A, FAM3B, FAM3D, FKBP7, FLRT2, FUT10, GNLY, GNMT, GP5, GPX7, GRN, GSTT2B, GSTT2B, GXYLT1, H6PD, ICAM5, IDUA, IGSF8, IL11RA, IL17RA, IL1RN, ISLR2, LGALS2, LMAN2L, LRRC15, LYZ, MANEA, MAPK3, MFAP2, MTHFS, NAAA, NAGPA, NDST1, NID2, NQO2, NTNG1, NUDT12, PAM, PDCD1LG2, PDGFRL, PLA2R1, PLXNB2, PMEL, POGLUT1, PPIE, PRDX1, PRSS22, PTGDS, PTGR1, PTN, QDPR, RMDN1, RNASE4, ROR2, RPN1, SEMA3E, SIGLEC12, SIGLEC14, SMPDL3A, SPARCL1, SPATA20, SPINK2, SPON1, STX8, TAPBP, TAPBPL, TCN2, TIE1, TPST2, TXNDC5, VTN, XXYLT1
Liver 160 0 44 AFP, APMAP, ARFIP1, ARSB, CBLN1, CCL15, CLEC12A, CPNE1, CTSS, ENPP7, EPHA2, ERAP1, ERAP2, FUT10, FUT3, GNMT, GNPNAT1, GPX7, GSTT2B, GSTT2B, IGFLR1, MBL2, MICB, MXRA7, NAAA, NID2, NMRAL1, NQO2, PDCD5, PEX14, PLA2G2A, POGLUT1, PPIE, PROC, RMDN1, SEC11C, SERPINA12, SIGLEC12, SIGLEC14, SPATA20, SPON1, TAPBPL, TGFBI, IGFLR1
Brain_Amygdala 62 0 19 CPNE1, ERAP1, ERAP2, FAS, GNMT, GPNMB, GSTT2B, GSTT2B, HLA-DQA2, HTATIP2, IL18R1, LAMC2, PPIE, SIGLEC14, SPATA20, TAPBPL, TDGF1, TPSB2, UROS
Colon_Sigmoid 289 0 68 ABO, ACYP2, ADAMTS13, ARFIP1, BPI, CAT, CBR3, CCL14, CCL23, CD59, CLEC12A, CNTN2, CPNE1, CREB3L4, CRELD1, CTSB, CTSS, DEFB1, DHX58, EMILIN3, ERAP1, ERAP2, FAS, FGFR3, FUT10, GFRA2, GNMT, GPX7, GSTO1, GSTT2B, GSTT2B, H6PD, HLA-DQA2, HTATIP2, IDUA, IGDCC4, IL17RA, LAMC2, LRRC15, LYZ, MANEA, MFAP2, MICB, MTHFS, NAAA, NDST1, NFASC, NOV, NQO2, NTNG1, NUDT12, OAF, PDCD1LG2, PLA2R1, POGLUT1, PPIE, PTGR1, RMDN1, RSPO4, SIGLEC12, SIGLEC14, SPATA20, SPINK2, TAPBP, TAPBPL, TCN2, TDGF1, UROS
Whole_Blood 503 1 MICB 106 ABO, ADAMTS13, AKR1C1, APMAP, ARFIP1, ARSB, BIN1, BPI, BST1, CBR1, CBR3, CD177, CD300A, CD33, CHI3L2, CHIT1, CLEC11A, CLEC12A, CNP, COCH, COL18A1, CRELD1, CRISPLD2, CST7, CTSB, CXCL5, DHX58, DPEP2, EPHB2, ERAP1, ERAP2, FAM177A1, FAM213A, FAM3B, FAS, FCER2, FCGR2B, FCN1, FCRL1, FCRL3, FUT10, GDF15, GLO1, GNLY, GNMT, GPX7, H6PD, HBZ, HTATIP2, ICAM1, IDUA, IGFLR1, IGSF8, IL12RB2, IL15RA, IL17RA, IL17RB, IL6R, LEPR, LGALS2, LGALS9, LILRA5, LILRB2, LIPN, LYZ, MANEA, MAPK3, MFGE8, MGAT4B, MICB, MPO, MTHFS, NAGK, NMRAL1, NQO2, NUDT12, OAS1, PCBD1, PDCD5, PF4V1, PI3, POGLUT1, PPIE, PTGDS, QDPR, RELT, RMDN1, RNASE2, RNASE4, RNASE6, RSPO4, SELL, SEMA4D, SERPINE2, SIGLEC12, SIGLEC14, SMAP1, SPATA20, STX8, TAPBPL, TNFAIP6, TNFSF12, TREM1, IGFLR1, UROS, XCL1