Dynamin report for checking simulation results (4.1)
Simulation setting: 2, number of simulation 50
True mean Progression Free Time (PFT)
$mi_gx
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
-+++ 5.317362 5.317362 15.95208 5.317362 5.317362
--++ 5.317362 5.317362 15.95208 5.317362 5.317362
++-+ 5.317362 5.317362 15.95208 5.317362 5.317362
-+-+ 5.317362 5.317362 15.95208 5.317362 5.317362
+--+ 5.317362 5.317362 15.95208 5.317362 5.317362
---+ 5.317362 5.317362 15.95208 5.317362 5.317362
-++- 5.317362 5.317362 15.95208 5.317362 5.317362
--+- 5.317362 5.317362 15.95208 5.317362 5.317362
++-- 5.317362 5.317362 15.95208 5.317362 5.317362
-+-- 5.317362 5.317362 15.95208 5.317362 5.317362
+--- 5.317362 5.317362 15.95208 5.317362 5.317362
---- 5.317362 5.317362 15.95208 5.317362 5.317362
$p_ctr
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
0.3333333 0.3333333 0.1111111 0.1111111 0.1111111
Graduation output
$superiority
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
all 0 0 1 0 0
ARA+ 0 0 1 0 0
ARA- 0 0 1 0 0
DRD+ 0 0 1 0 0
DRD- 0 0 1 0 0
TP53+ 0 0 1 0 0
TP53- 0 0 1 0 0
TEfus+ 0 0 1 0 0
TEfus- 0 0 1 0 0
$inferiority
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
all 0 0 0 0 0
ARA+ 1 1 0 1 0
ARA- 0 0 0 0 0
DRD+ 0 0 0 0 0
DRD- 0 0 0 0 0
TP53+ 0 0 0 0 0
TP53- 0 0 0 0 0
TEfus+ 0 0 0 0 0
TEfus- 1 1 0 1 1
Final probability of superioriry by signatures and biomarkers subtypes
$p_sign
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
all 0.000 0.000 0.993 0.000 0.000
ARA+ 0.000 0.000 0.595 0.000 0.000
ARA- 0.000 0.000 0.994 0.000 0.001
DRD+ 0.000 0.000 0.340 0.000 0.000
DRD- 0.000 0.000 1.000 0.000 0.000
TP53+ 0.070 0.009 1.000 0.010 0.013
TP53- 0.000 0.000 0.480 0.000 0.000
TEfus+ 0.084 0.007 0.971 0.005 0.046
TEfus- 0.000 0.000 0.938 0.000 0.000
$p_type
Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
-+++ 0.386 0.274 0.314 0.274 0.273
--++ 0.854 0.510 1.000 0.068 0.307
++-+ 0.067 0.028 0.494 0.025 0.075
-+-+ 0.379 0.341 0.866 0.345 0.305
+--+ 0.058 0.022 0.402 0.022 0.334
---+ 0.141 0.105 0.447 0.107 0.124
-++- 0.044 0.029 0.283 0.007 0.025
--+- 0.038 0.005 1.000 0.086 0.000
++-- 0.002 0.001 0.136 0.003 0.000
-+-- 0.007 0.003 0.393 0.004 0.001
+--- 0.000 0.000 0.960 0.000 0.000
---- 0.015 0.028 0.051 0.013 0.029
Probabilities of superiority over time
Randomization probabilities over time
Number of enrolled participants (over time)
Control Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
-+++ 4 1 0 1 0 0
--++ 76 25 33 45 10 6
++-+ 33 5 7 1 6 26
-+-+ 2 0 0 2 0 1
+--+ 38 10 7 5 11 29
---+ 17 1 2 2 10 11
-++- 25 3 4 1 11 7
--+- 132 1 16 38 15 63
++-- 46 7 17 4 22 10
-+-- 23 4 6 10 3 6
+--- 229 77 53 51 40 11
---- 39 12 9 2 10 6
Control Enzalutamide Abiraterone Radium 223 Cabazitaxel Docetaxel
all 664 146 154 162 138 176
ARA+ 346 99 84 61 79 76
ARA- 318 47 70 101 59 100
DRD+ 346 99 84 61 79 76
DRD- 318 47 70 101 59 100
TP53+ 237 30 53 85 36 76
TP53- 427 116 101 77 102 100
TEfus+ 170 42 49 56 37 73
TEfus- 494 104 105 106 101 103