1. General Results (Actemra) - Slide no. 2

Summary descriptives table by groups of `IDD’
Initial Visit N=1511 Remaining Visit(s) N=6382 p.overall
Gender: 0.183
    female 917 (60.7%) 3751 (58.8%)
    male 594 (39.3%) 2631 (41.2%)
AGE.years 52.5 (12.4) 53.6 (12.2) 0.002
DOD.years 7.68 (6.72) 8.31 (6.67) 0.003
ANA: <0.001
    Negative 868 (73.1%) 4388 (79.6%)
    Positive 320 (26.9%) 1125 (20.4%)
RF: 0.012
    Negative 311 (22.9%) 1565 (26.2%)
    Positive 1048 (77.1%) 4404 (73.8%)
SICCA.Symptoms 215 (18.1%) 895 (17.1%) 0.459
Smoking 114 (10.8%) 335 (8.50%) 0.025
Current.Steroid 295 (21.3%) 593 (9.63%) <0.001
ANTI.CCP: <0.001
    Negative 420 (35.4%) 2242 (41.8%)
    Positive 768 (64.6%) 3124 (58.2%)
Summary descriptives table by groups of `IDD’
Initial Visit N=1511 Remaining Visit(s) N=6382 p.overall N
Gender: female 917 (60.7%) 3751 (58.8%) 0.183 7893
AGE.years 52.5 (12.4) 53.6 (12.2) 0.002 7828
DOD.years 7.68 (6.72) 8.31 (6.67) 0.003 6454
ANA: Positive 320 (26.9%) 1125 (20.4%) <0.001 6701
RF: Positive 1048 (77.1%) 4404 (73.8%) 0.012 7328
SICCA.Symptoms: Yes 215 (18.1%) 895 (17.1%) 0.459 6408
Smoking 114 (10.8%) 335 (8.50%) 0.025 4998
Current.Steroid 295 (21.3%) 593 (9.63%) <0.001 7546
ANTI.CCP: Positive 768 (64.6%) 3124 (58.2%) <0.001 6554

2. General Results (Actemra) - Slide no. 2 - Comparison between Kuwaiti’s and non-Kuwaiti’s

Summary descriptives table by groups of `nationality.G’
Kuwaiti’s N=795 non-Kuwaiti’s N=716 p.overall
Gender: <0.001
    female 555 (69.8%) 361 (50.4%)
    male 240 (30.2%) 355 (49.6%)
AGE.years 54.5 (13.2) 50.3 (11.0) <0.001
DOD.years 8.88 (7.46) 6.33 (5.46) <0.001
ANA: 0.677
    Negative 433 (72.4%) 436 (73.6%)
    Positive 165 (27.6%) 156 (26.4%)
RF: 0.001
    Negative 187 (26.5%) 124 (18.9%)
    Positive 519 (73.5%) 533 (81.1%)
SICCA.Symptoms 162 (24.8%) 54 (10.0%) <0.001
Smoking 42 (7.72%) 72 (14.0%) 0.001
Current.Steroid 72 (9.76%) 114 (17.4%) <0.001
ANTI.CCP: <0.001
    Negative 247 (41.1%) 175 (29.7%)
    Positive 354 (58.9%) 415 (70.3%)
Summary descriptives table by groups of `nationality.G’
Kuwaiti’s N=795 non-Kuwaiti’s N=716 p.overall N
Gender: female 555 (69.8%) 361 (50.4%) <0.001 1511
AGE.years 54.5 (13.2) 50.3 (11.0) <0.001 1493
DOD.years 8.88 (7.46) 6.33 (5.46) <0.001 1266
ANA: Positive 165 (27.6%) 156 (26.4%) 0.677 1190
RF: Positive 519 (73.5%) 533 (81.1%) 0.001 1363
SICCA.Symptoms: Yes 162 (24.8%) 54 (10.0%) <0.001 1192
Smoking 42 (7.72%) 72 (14.0%) 0.001 1059
Current.Steroid 72 (9.76%) 114 (17.4%) <0.001 1393
ANTI.CCP: Positive 354 (58.9%) 415 (70.3%) <0.001 1191

3. DMARDs Usage (Actemra) - Slide no. 3 - Results from last visit of the patient(s)

Summary descriptives table by groups of `nationality.G’
Kuwaiti’s N=795 non-Kuwaiti’s N=716 p.overall
MTX 446 (56.1%) 536 (74.9%) <0.001
SSZ 63 (7.92%) 199 (27.8%) <0.001
LEF 70 (8.81%) 161 (22.5%) <0.001
HCQ 182 (22.9%) 353 (49.3%) <0.001
IMUR 16 (2.01%) 18 (2.51%) 0.629
CYC 1 (0.13%) 0 (0.00%) 1.000

4. Biologics Usage (Actemra) - Slide no. 9 - Results from last visit of the patient(s)

Summary descriptives table by groups of `nationality.G’
Kuwaiti’s N=795 non-Kuwaiti’s N=716 p.overall
RIT 121 (15.2%) 20 (2.79%) <0.001
ADA 100 (12.6%) 13 (1.82%) <0.001
TOC 18 (2.26%) 3 (0.42%) 0.005
ETA 59 (7.42%) 16 (2.23%) <0.001
ABA 42 (5.28%) 4 (0.56%) <0.001
INF 27 (3.40%) 1 (0.14%) <0.001
TOF: No 795 (100%) 716 (100%) .
CER 19 (2.39%) 1 (0.14%) <0.001
GOL 3 (0.38%) 6 (0.84%) 0.322

4. Monotherpy and Combination (Actemra) - Slide no. 11 - Results from last visit of the patient(s)

## Warning in createTable(ACT5, hide = c(MTX = "No", SSZ = "No", LEF = "No", :
## variables MTX, SSZ, LEF, HCQ, IMUR, CYC specified in 'hide' not found
Summary descriptives table by groups of `BioMono2’
Combination N=325 Monotherapy N=127 p.overall N
Gender: 1.000 452
    female 224 (68.9%) 88 (69.3%)
    male 101 (31.1%) 39 (30.7%)
AGE.years 55.9 (12.1) 54.5 (13.4) 0.320 442
DOD.years 9.70 (7.31) 9.93 (9.07) 0.816 388
ANA: 0.996 359
    Negative 187 (73.3%) 77 (74.0%)
    Positive 68 (26.7%) 27 (26.0%)
RF: 0.251 412
    Negative 68 (23.1%) 34 (29.1%)
    Positive 227 (76.9%) 83 (70.9%)
SICCA.Symptoms 65 (24.2%) 31 (30.1%) 0.299 372
Smoking 26 (11.5%) 5 (6.33%) 0.278 306
Current.Steroid 26 (8.12%) 9 (7.38%) 0.950 442
ANTI.CCP: 0.193 350
    Negative 105 (42.2%) 51 (50.5%)
    Positive 144 (57.8%) 50 (49.5%) 

## tbl$BioMono2 : 
##             Frequency   %(NA+) cum.%(NA+)   %(NA-) cum.%(NA-)
## <NA>             1059     70.1      100.0      0.0      100.0
## Combination       325     21.5       21.5     71.9       71.9
## Monotherapy       127      8.4       29.9     28.1      100.0
##   Total          1511    100.0      100.0    100.0      100.0

5. On Biologics (Actemra) - Slide no. 8 - Results from last visit of the patient(s)

## Warning in createTable(ACT6, hide = c(MTX = "No", SSZ = "No", LEF = "No", :
## variables MTX, SSZ, LEF, HCQ, IMUR, CYC specified in 'hide' not found
Summary descriptives table by groups of `nationality.G’
Kuwaiti’s N=795 non-Kuwaiti’s N=716 p.overall N
Gender: <0.001 1511
    female 555 (69.8%) 361 (50.4%)
    male 240 (30.2%) 355 (49.6%)
AGE.years 54.5 (13.2) 50.3 (11.0) <0.001 1493
DOD.years 8.88 (7.46) 6.33 (5.46) <0.001 1266
ANA: 0.677 1190
    Negative 433 (72.4%) 436 (73.6%)
    Positive 165 (27.6%) 156 (26.4%)
RF: 0.001 1363
    Negative 187 (26.5%) 124 (18.9%)
    Positive 519 (73.5%) 533 (81.1%)
SICCA.Symptoms: <0.001 1192
    No 492 (75.2%) 484 (90.0%)
    Yes 162 (24.8%) 54 (10.0%)
Smoking: 0.001 1059
    No 502 (92.3%) 443 (86.0%)
    Yes 42 (7.72%) 72 (14.0%)
Current.Steroid: <0.001 1393
    No 666 (90.2%) 541 (82.6%)
    Yes 72 (9.76%) 114 (17.4%)
ANTI.CCP: <0.001 1191
    Negative 247 (41.1%) 175 (29.7%)
    Positive 354 (58.9%) 415 (70.3%)
onbio: <0.001 1511
    No 407 (51.2%) 652 (91.1%)
    Yes 388 (48.8%) 64 (8.94%) 

## tbl$onbio : 
##         Frequency Percent Cum. percent
## No           1059    70.1         70.1
## Yes           452    29.9        100.0
##   Total      1511   100.0        100.0

6. Comaprison between Mono and Combination (Actemra) - Slide no. 12 - Results from last visit of the patient(s)

## Warning in createTable(ACT7, hide = c(MTX = "No", SSZ = "No", LEF = "No", :
## variables MTX, SSZ, LEF, HCQ, IMUR, CYC specified in 'hide' not found
Summary descriptives table by groups of `BioMono2’
Combination N=325 Monotherapy N=127 p.overall N
RIT 93 (28.6%) 48 (37.8%) 0.075 452
ADA 99 (30.5%) 14 (11.0%) <0.001 452
TOC 11 (3.38%) 10 (7.87%) 0.074 452
ETA 50 (15.4%) 25 (19.7%) 0.335 452
ABA 31 (9.54%) 15 (11.8%) 0.586 452
INF 21 (6.46%) 7 (5.51%) 0.873 452
TOF: No 325 (100%) 127 (100%) . 452
CER 12 (3.69%) 8 (6.30%) 0.339 452
GOL 9 (2.77%) 0 (0.00%) 0.067 452

7. Comaprison between Mono and Combination (Actemra) - Slide no. 12 - Results from last visit of the (Only Kuwaiti’s) patient(s)

## Warning in createTable(ACT8, hide = c(MTX = "No", SSZ = "No", LEF = "No", :
## variables MTX, SSZ, LEF, HCQ, IMUR, CYC specified in 'hide' not found
Summary descriptives table by groups of `BioMono2’
Combination N=264 Monotherapy N=124 p.overall N
RIT 73 (27.7%) 48 (38.7%) 0.038 388
ADA 87 (33.0%) 13 (10.5%) <0.001 388
TOC 8 (3.03%) 10 (8.06%) 0.052 388
ETA 36 (13.6%) 23 (18.5%) 0.269 388
ABA 27 (10.2%) 15 (12.1%) 0.706 388
INF 20 (7.58%) 7 (5.65%) 0.629 388
TOF: No 264 (100%) 124 (100%) . 388
CER 11 (4.17%) 8 (6.45%) 0.471 388
GOL 3 (1.14%) 0 (0.00%) 0.554 388

7. Comaprison between Mono and Combination based on DAS28 (Actemra) - Slide no. 14 - Results from last visit of the (Only Kuwaiti’s) patient(s)

BioMono2 INF N mean sd se
Combination Yes 20 3.362550 1.620169 0.3622809
Monotherapy Yes 7 2.425286 1.085025 0.4101007
BioMono2 ETA N mean sd se
Combination Yes 35 2.586029 0.9320379 0.1575432
Monotherapy Yes 23 2.697000 1.0441089 0.2177118
BioMono2 ADA N mean sd se
Combination Yes 87 2.841977 1.101717 0.1181164
Monotherapy Yes 13 2.757077 0.893437 0.2477949
BioMono2 RIT N mean sd se
Combination Yes 73 2.399822 1.082578 0.1267062
Monotherapy Yes 48 2.610083 1.246750 0.1799529
BioMono2 ABA N mean sd se
Combination Yes 27 2.981111 1.417600 0.2728172
Monotherapy Yes 15 3.728267 1.383728 0.3572770
BioMono2 TOC N mean sd se
Combination Yes 8 2.55375 0.8977912 0.3174171
Monotherapy Yes 10 2.25630 1.3716234 0.4337454
BioMono2 CER N mean sd se
Combination Yes 11 2.862727 0.9813155 0.2958777
Monotherapy Yes 8 2.678125 1.2584212 0.4449191
BioMono2 GOL N mean sd se
Combination Yes 3 3.272 0.6083593 0.3512364