Pan-cancer patterns of somatic copy number alteration

Travis I Zack, Steven E Schumacher, Scott L Carter, Andrew D Cherniack, Gordon Saksena, Barbara Tabak, Michael S Lawrence, Cheng-Zhong Zhang, Jeremiah Wala, Craig H Mermel, Carrie Sougnez, Stacey B Gabriel, Bryan Hernandez, Hui Shen, Peter W Laird, Gad Getz, Matthew Meyerson & Rameen Beroukhim.

Nature Genetics 45, 1134–1140 (2013) doi:10.1038/ng.2760

Published online 26 September 2013

Determining how somatic copy number alterations (SCNAs) promote cancer is an important goal. We characterized SCNA patterns in 4,934 cancers from The Cancer Genome Atlas Pan-Cancer data set.

Disease Samples %
Bladder 136 2.8%
Breast 872 17.7%
Colorectal 585 11.9%
GBM 580 11.8%
Head and neck 310 6.3%
Kidney clear cell 497 10.1%
AML 194 3.9%
Lung adeno 357 7.2%
Lung squamous 344 7%
Ovarian 563 11.4%
Endometrial 496 10.1%
pan-cancer 4934 100%

Supplementary Table 2: Pan-cancer regions of significant SCNA: Deletions

Peak Name Rank Genomic location Peak region GISTIC q-value Gene count Target(s) Frequently mutated genesB
CDKN2A 1 9p21.3 chr9:21865498-22448737 0 4 CDKN2AK CDKN2A = 4.4e-15
STK11 2 19p13.3 chr19:1103715-1272039 1,46E-238 7 STK11K STK11 = 2.5e-13
PDE4D 3 5q11.2 chr5:58260298-59787985 2,02E-143 3 PDE4D
PARK2 4 6q26 chr6:161693099-163153207 5,85E-137 1 PARK2K
LRP1B 5 2q22.1 chr2:139655617-143637838 4,25E-107 1 LRP1B
CSMD1 6 8p23.2 chr8:2079140-6262191 2,39E-96 1 CSMD1
1p36.23 7 1p36.23 chr1:7829287-8925111 1,23E-93 8
ARID1A 8 1p36.11 chr1:26900639-27155421 5,74E-87 2 ARID1AK ARID1A = 1.5e-14
PTEN 9 10q23.31 chr10:89615138-90034038 1,12E-79 2 PTENK PTEN = 2.2e-15
WWOX 10 16q23.1 chr16:78129058-79627770 8,14E-76 1 WWOX WWOX = 0.092
RB1 11 13q14.2 chr13:48833767-49064807 3,88E-75 2 RB1K RB1 = 1.7e-13
FAM190A 12 4q22.1 chr4:90844993-93240505 9,26E-75 1 FAM190A
2q37.3 13 2q37.3T chr2:241544527-243199373 1,77E-70 29 ING5E
22q13.32 14 22q13.32T chr22:48026910-51304566 8,20E-65 45 BRD1E, HDAC10E
11p15.5 15 11p15.5T chr11:1-709860 1,02E-62 34 SIRT3E, PHRF1E HRAS = 7.8e-13
LINC00290 16 4q34.3 chr4:178911874-183060693 1,21E-55 1 LINC00290
FHIT 17 3p14.2 chr3:59034763-61547330 3,01E-55 1 FHIT
RBFOX1 18 16p13.3 chr16:5144019-7771745 1,00E-45 1 RBFOX1
PTPRD 19 9p24.1 chr9:8310705-12693402 3,24E-38 1 PTPRD
18q23 20 18q23T chr18:74979706-78077248 1,69E-37 12
FAT1 21 4q35.2 chr4:187475875-188227950 6,81E-36 1 FAT1K FAT1 = 2.4e-15
MPHOSPH8 22 13q12.11T chr13:1-20535070 2,57E-31 10 MPHOSPH8E
15q15.1 23 15q15.1 chr15:41795901-42068054 2,71E-29 4 MGA = 0.0083, RPAP1=0.035
11q25 24 11q25T chr11:133400280-135006516 4,93E-26 14
1p13.2 25 1p13.2 chr1:110048528-117687124 1,69E-25 100 TRIM33E NRAS=1.8e-13, CD58=0.079
NF1 26 17q11.2 chr17:29326736-29722618 6,59E-23 5 NF1K NF1 = 3.3e-13
MACROD2 27 20p12.1 chr20:14302876-16036135 9,00E-19 3 MACROD2
7p22.3 28 7p22.3T chr7:1-1496620 1,04E-17 18
6p25.3 29 6p25.3 chr6:1608837-2252425 3,01E-17 2
21q11.2 30 21q11.2T chr21:1-15482604 2,34E-14 14
9p13.1 31 9p13.1 chr9:38619152-71152237 9,75E-14 48
ZNF132 32 19q13.43T chr19:58661582-59128983 3,77E-13 24 TRIM28E, ZNF132
5q15 33 5q15 chr5:73236070-114508587 8,15E-13 156 APCK, CHD1K APC=2.6e-13, RASA1=0.0029
MLL3 34 7q36.1 chr7:151817415-152136074 9,26E-13 1 MLL3K,E MLL3 = 1.1e-05
19q13.32 35 19q13.32 chr19:47332686-47763284 2,38E-12 10
15q12 36 15q12T chr15:1-32929863 3,40E-11 155 OTUD7A = 0.027
12q24.33 37 12q24.33T chr12:131692956-133851895 1,24E-10 27 POLE=3.9e-05, PGAM5=0.038
10q26.3 38 10q26.3T chr10:135190263-135534747 2,09E-10 14
6q21 39 6q21 chr6:86319089-117076132 4,56E-10 141 PRDM1E, HDAC2E, PRDM13E PRDM1 = 0.00054
PPP2R2A 40 8p21.2 chr8:25896447-26250295 1,78E-09 1 PPP2R2A
IKZF2 41 2q34 chr2:211542637-214143899 3,24E-09 4 IKZF2K, ERBB4 ERBB4 = 0.00058
CNTN4 42 3p26.3T chr3:1-3100786 6,44E-09 3 CNTN4
3p12.2 43 3p12.2 chr3:75363575-86988125 1,22E-07 12 ROBO1, CADM2
RAD51B 44 14q24.1 chr14:68275375-69288431 1,38E-07 2 RAD51B ZFP36L1 = 0.0016
11q23.1 45 11q23.1 chr11:105849158-117024891 5,31E-07 84 ATMK ATM=1.4e-06, POU2AF1=0.082
IMMP2L 46 7q31.1 chr7:109599468-111366370 5,74E-07 2 IMMP2L
NEGR1 47 1p31.1 chr1:71699756-74522473 7,25E-07 2 NEGR1
BRCA1 48 17q21.31 chr17:41178765-41336147 7,25E-07 2 BRCA1K BRCA1 = 3.5e-08
9q34.3 49 9q34.3 chr9:135441810-139646221 8,73E-06 94 NOTCH1K, BRD3E, GTF3C4E NOTCH1=1e-08, RXRA=2.1e-05, COL5A1=0.0022, TSC1=0.012
ANKS1B 50 12q23.1 chr12:99124001-100431272 8,73E-06 2 ANKS1B
DMD 51 Xp21.2 chrX:30865118-34644819 5,15E-05 4 DMD
ZMYND11 52 10p15.3T chr10:1-857150 7,12E-05 4 ZMYND11E
PRKG1 53 10q11.23 chr10:52644085-54061437 9,79E-05 3 PRKG1
FOXK2 54 17q25.3 chr17:80443432-80574531 0,00019271 1 FOXK2
AGBL4 55 1p33 chr1:48935280-50514967 0,000219 2 AGBL4
CDKN1B 56 12p13.1 chr12:12710990-12966966 0,00035777 5 CDKN1BK CDKN1B = 2.2e-06
14q32.33 57 14q32.33T chr14:94381429-107349540 0,00074358 227 SETD3E, TDRD9E AKT1=2.1e-13, TRAF3=9.7e-05
14q11.2 58 14q11.2T chr14:1-30047530 0,0010181 162 PRMT5E, CHD8E CHD8 = 0.034
2p25.3 59 2p25.3T chr2:1-20072169 0,0011137 86 MYCNK MYCN=0.068
5q35.3 60 5q35.3T chr5:153840473-180915260 0,0028515 212 NSD1E, ODZ2 NPM1=3.5e-13, NSD1=1.9e-09, ZNF454=0.0019, UBLCP1=0.03, GABRB2=0.07
PTTG1IP 61 21q22.3 chr21:46230687-46306160 0,012227 1 PTTG1IP
22q11.1 62 22q11.1T chr22:1-17960585 0,020332 15
SMAD4 63 18q21.2 chr18:48472083-48920689 0,036866 3 SMAD4K SMAD4 = 6.6e-15
17p13.3 64 17p13.3T chr17:1-1180022 0,040814 16
4p16.3 65 4p16.3T chr4:1-1243876 0,056345 27
9p21.2 66 9p21.2 chr9:27572512-28982153 0,091742 3
10q25.1 67 10q25.1 chr10:99340084-113910615 0,11879 137 HPSE2, SMNDC1E SMC3=0.00031, GSTO2=0.086
SMYD3 68 1q44 chr1:245282267-247110824 0,15417 8 SMYD3E
8p11.21 69 8p11.21 chr8:42883855-47753079 0,17382 4
Xp22.33 70 Xp22.33T chrX:1-11137490 0,21462 52 MXRA5 = 0.031

Notes

Supplementary Table 3

ng.2760-S5.xlsx del_genes.All_cancer

cytoband q value residual q value wide peak boundaries genes in wide peak
9p21.3 0 0 chr9:21865498-22448737 CDKN2A,CDKN2B,C9orf53,CDKN2B-AS1
19p13.3 1.46E-238 1.46E-238 chr19:1103715-1272039 ATP5D,GPX4,STK11,SBNO2,MIDN,CIRBP-AS1,C19orf26
5q11.2 3.18E-156 2.02E-143 chr5:58260298-59787985 hsa-mir-582,PDE4D,PART1
6q26 5.85E-137 5.85E-137 chr6:161693099-163153207 PARK2
2q22.1 4.25E-107 4.25E-107 chr2:139655617-143637838 LRP1B
8p23.2 2.39E-96 2.39E-96 chr8:2079140-6262191 CSMD1
1p36.23 1.67E-178 1.23E-93 chr1:7829287-8925111 RERE,TNFRSF9,PER3,VAMP3,UTS2,PARK7,SLC45A1,ERRFI1
1p36.11 1.93E-173 5.74E-87 chr1:26900639-27155421 ARID1A,PIGV
10q23.31 1.55E-86 1.12E-79 chr10:89615138-90034038 PTEN,KLLN
16q23.1 8.14E-76 8.14E-76 chr16:78129058-79627770 WWOX
13q14.2 3.01E-91 3.88E-75 chr13:48833767-49064807 RB1,LPAR6
4q22.1 9.16E-75 9.26E-75 chr4:90844993-93240505 FAM190A
2q37.3 8.65E-100 1.77E-70 chr2:241544527-243199373 hsa-mir-3133,AGXT,KIF1A,BOK,DTYMK,GPR35,HDLBP,2-Sep,PDCD1,PPP1R7,FARP2,STK25,PASK,ATG4B,SNED1,ANO7,THAP4,GAL3ST2,C2orf54,ING5,NEU4,MTERFD2,LOC200772,CXXC11,AQP12A,AQP12B,D2HGDH,LOC728323,BOK-AS1
22q13.32 8.20E-65 8.20E-65 chr22:48026910-51304566 ACR,ARSA,CHKB,CPT1B,TYMP,MAPK11,MAPK12,SBF1,PPP6R2,ZBED4,SCO2,RABL2B,MLC1,MAPK8IP2,PLXNB2,BRD1,FAM19A5,NCAPH2,MOV10L1,MIOX,PANX2,ALG12,CRELD2,ADM2,TRABD,SELO,HDAC10,SHANK3,TUBGCP6,LOC90834,LMF2,KLHDC7B,LOC284933,RPL23AP82,C22orf34,CHKB-CPT1B,IL17REL,FAM116B,PIM3,ODF3B,SYCE3,LOC100128946,LOC100144603,MIR3201,MIR4535
11p15.5 1.02E-62 1.02E-62 chr11:1-709860 DRD4,HRAS,IRF7,PSMD13,RNH1,SCT,RASSF7,IFITM1,IFITM3,DEAF1,IFITM2,PKP3,SIRT3,BET1L,CDHR5,PHRF1,SIGIRR,RIC8A,ATHL1,PTDSS2,ODF3,LRRC56,LOC143666,SCGB1C1,NLRP6,C11orf35,TMEM80,ANO9,B4GALNT4,IFITM5,MIR210,LOC653486,LOC100133161,MIR210HG
4q34.3 3.63E-136 1.21E-55 chr4:178911874-183060693 LINC00290
3p14.2 6.98E-65 3.01E-55 chr3:59034763-61547330 FHIT
16p13.3 9.88E-46 1.00E-45 chr16:5144019-7771745 RBFOX1
9p24.1 2.85E-40 3.24E-38 chr9:8310705-12693402 PTPRD
18q23 1.92E-43 1.69E-37 chr18:74979706-78077248 NFATC1,CTDP1,TXNL4A,ADNP2,KCNG2,SALL3,RBFA,PQLC1,PARD6G,ATP9B,HSBP1L1,LOC100130522
4q35.2 2.65E-117 6.81E-36 chr4:187475875-188227950 FAT1
13q12.11 1.59E-50 2.57E-31 chr13:1-20535070 TUBA3C,ZMYM5,MPHOSPH8,PSPC1,TPTE2,PHF2P1,ANKRD20A9P,LINC00442,ANKRD26P3,LINC00421
15q15.1 7.94E-54 2.71E-29 chr15:41795901-42068054 TYRO3,MGA,RPAP1,MIR626
11q25 2.77E-40 4.93E-26 chr11:133400280-135006516 IGSF9B,NCAPD3,ACAD8,B3GAT1,THYN1,JAM3,GLB1L2,VPS26B,GLB1L3,SPATA19,LOC283174,LOC283177,LOC100128239,MIR4697
1p13.2 1.04E-28 1.69E-25 chr1:110048528-117687124 ADORA3,ALX3,AMPD1,AMPD2,RHOC,ATP1A1,ATP5F1,CAPZA1,CASQ2,CD2,CD53,CD58,CHI3L2,CSF1,GNAI3,GNAT2,GSTM1,GSTM2,GSTM3,GSTM4,GSTM5,IGSF3,KCNA2,KCNA3,KCNA10,KCNC4,KCND3,MOV10,NGF,NHLH2,NRAS,OVGP1,PTGFRN,RAP1A,SLC16A1,SYCP1,TSHB,WNT2B,CSDE1,TTF2,SLC16A4,CD101,LRIG2,TSPAN2,BCAS2,CEPT1,HBXIP,AP4B1,PHTF1,AHCYL1,DDX20,PTPN22,CHIA,TRIM33,RSBN1,ST7L,SLC22A15,LRIF1,CTTNBP2NL,FAM212B,OLFML3,AMIGO1,RBM15,DCLRE1B,WDR77,EPS8L3,DENND2D,SIKE1,TRIM45,VANGL1,GPR61,PROK1,ATP1A1OS,FAM40A,MAB21L3,DRAM2,C1orf88,C1orf162,SYT6,RP11-165H20.1,DENND2C,UBL4B,HIPK1,AKR7A2P1,MAGI3,FAM19A3,PPM1J,SLC6A17,MIR197,LOC440600,BCL2L15,PGCP1,CYMP,LOC643441,MIR942,LOC100129269,LOC100287722,MIR320B1,MIR4256,LOC100506343
17q11.2 1.40E-27 6.59E-23 chr17:29326736-29722618 EVI2A,EVI2B,NF1,OMG,MIR4733
20p12.1 9.00E-19 9.00E-19 chr20:14302876-16036135 FLRT3,MACROD2,MACROD2-AS1
7p22.3 1.04E-17 1.04E-17 chr7:1-1496620 GPER,PDGFA,PRKAR1B,ADAP1,SUN1,GET4,CYP2W1,HEATR2,FAM20C,C7orf50,ZFAND2A,COX19,GPR146,UNCX,FLJ44511,LOC442497,MIR339,LOC100288524
6p25.3 3.01E-17 3.01E-17 chr6:1608837-2252425 FOXC1,GMDS
21q11.2 2.34E-14 2.34E-14 chr21:1-15482604 hsa-mir-3118-5,BAGE,TPTE,C21orf15,BAGE4,BAGE3,BAGE2,ANKRD30BP2,POTED,ANKRD20A11P,TEKT4P2,MIR3156-3,MIR3687,MIR3648
9p13.1 1.76E-16 9.75E-14 chr9:38619152-71152237 hsa-mir-1299,PGM5,ZNF658,FAM75A7,CNTNAP3,ANKRD20A1,FAM201A,CBWD5,LOC286297,FOXD4L3,AQP7P1,KGFLP1,FAM75A6,MGC21881,FAM74A1,FAM74A4,ZNF658B,LOC440896,ANKRD20A3,ANKRD20A2,AQP7P3,LOC442421,CBWD3,FAM27A,LOC572558,PGM5P2,LOC642236,FAM75A2,FAM75A4,LOC642929,LOC643648,CBWD6,FAM75A1,FOXD4L6,FOXD4L5,LOC653501,KGFLP2,FAM75A3,FAM75A5,FAM74A3,CNTNAP3B,ANKRD20A4,FOXD4L2,LOC100132352,FAM27C,FAM95B1,FAM27B,LOC100133920
19q13.43 1.06E-24 3.77E-13 chr19:58661582-59128983 A1BG,RPS5,ZNF8,MZF1,ZNF132,UBE2M,TRIM28,ZNF274,SLC27A5,ZNF324,CHMP2A,ZNF544,ZNF446,MGC2752,ZBTB45,ZNF837,ZNF497,ZNF584,ZSCAN22,ZNF324B,A1BG-AS1,LOC646862,LOC100131691,MIR4754
5q15 3.32E-37 8.15E-13 chr5:73236070-114508587 hsa-mir-548f-3,hsa-mir-548p,APC,ARSB,BHMT,CAMK4,CAST,CCNH,CETN3,CHD1,CKMT2,COX7C,CRHBP,HAPLN1,VCAN,DHFR,EFNA5,F2R,F2RL1,F2RL2,FER,GLRX,HEXB,HMGCR,KCNN2,LNPEP,MAN2A1,MCC,MEF2C,MSH3,PAM,PCSK1,RASA1,RASGRF2,RPS23,SRP19,TBCA,NR2F1,THBS4,XRCC4,ST8SIA4,REEP5,ENC1,AP3B1,PDE8B,NREP,RAB9BP1,HOMER1,SCAMP1,TTC37,ZFYVE16,PJA2,EDIL3,COL4A3BP,LHFPL2,NSA2,POLR3G,IQGAP2,RHOBTB3,ELL2,SV2C,PPIP5K2,OTP,SSBP2,BHMT2,FAM169A,RNU5E-1,RNU5D-1,DMGDH,GCNT4,POLK,ERAP1,FLJ11235,GIN1,AGGF1,WDR41,RIOK2,ARRDC3,EPB41L4A,ERAP2,FBXL17,YTHDC2,MCTP1,NUDT12,ATG10,SPATA9,TSSK1B,FAM172A,GPR98,ZCCHC9,ANKRD32,ZBED3,GFM2,SPZ1,TSLP,C5orf30,SLC25A46,ATP6AP1L,EPB41L4A-AS1,LYSMD3,SLCO6A1,JMY,POU5F2,POC5,STARD4,WDR36,ACOT12,TMEM167A,MBLAC2,TMEM161B,ARSK,FAM81B,PAPD4,DCP2,LIX1,FAM151B,S100Z,C5orf27,CMYA5,ANKRD31,SERINC5,KIAA0825,GPR150,NBPF22P,RGMB,RFESD,ANKRD34B,FAM174A,MTX3,SLCO4C1,MIR9-2,CRSP8P,FLJ42709,FLJ35946,TMEM232,LOC644936,LINC00461,SNORA13,SCARNA18,SNORA47,MIR583,LOC728723,LOC100129716,LOC100131067,LOC100133050,LOC100289230,LOC100289673,NCRUPAR,MIR2277,MIR4280,MTRNR2L2,MIR3607,MIR3660,LOC100505678,LOC100505894,MIR3977
7q36.1 5.74E-13 9.26E-13 chr7:151817415-152136074 MLL3
19q13.32 1.12E-23 2.38E-12 chr19:47332686-47763284 AP2S1,ARHGAP35,NPAS1,SAE1,ZC3H4,BBC3,TMEM160,SNAR-E,MIR3191,MIR3190
15q12 6.05E-52 3.40E-11 chr15:1-32929863 hsa-mir-1268,hsa-mir-3118-6,hsa-mir-3118-4,APBA2,NBEAP1,CHRNA7,GABRA5,GABRB3,GABRG3,IPW,TRPM1,NDN,OCA2,SNRPN,TJP1,UBE3A,MKRN3,PAR5,HERC2,SNURF,ARHGAP11A,FAN1,CYFIP1,FAM189A1,C15orf2,DKFZP434L187,KLF13,MAGEL2,MTMR10,NDNL2,ATP10A,NIPA2,CHRFAM7A,ULK4P3,ULK4P1,ARHGAP11B,SNORD107,TUBGCP5,NIPA1,PAR1,OTUD7A,LOC283683,OR4N4,LOC283710,HERC2P3,GOLGA6L1,GOLGA8G,GOLGA8IP,SNORD108,SNORD109B,SNORD115-1,WHAMMP3,POTEB,SNORD64,PAR4,PAR-SN,LOC348120,GOLGA8E,OR4M2,OR4N3P,HERC2P2,MIR211,NF1P2,HERC2P9,WHAMMP2,LOC503519,CHEK2P2,LOC646214,CXADRP2,LOC646278,REREP3,LOC653061,LOC653075,SNORD116-19,GOLGA6L6,LOC727924,GOLGA8C,PWRN1,PWRN2,SNORD116-1,SNORD116-2,SNORD116-3,SNORD116-4,SNORD116-5,SNORD116-8,SNORD116-10,SNORD116-11,SNORD116-12,SNORD116-13,SNORD116-14,SNORD116-15,SNORD116-16,SNORD116-18,SNORD116-20,SNORD116-21,SNORD116-22,SNORD116-23,SNORD116-24,SNORD116-25,SNORD115-2,SNORD116-26,SNORD116-27,SNORD115-3,SNORD115-4,SNORD115-5,SNORD115-6,SNORD115-7,SNORD115-8,SNORD115-9,SNORD115-10,SNORD115-11,SNORD115-13,SNORD115-14,SNORD115-15,SNORD115-16,SNORD115-17,SNORD115-18,SNORD115-20,SNORD115-22,SNORD115-23,SNORD115-25,SNORD115-26,SNORD115-29,SNORD115-30,SNORD115-31,SNORD115-32,SNORD115-33,SNORD115-34,SNORD115-35,SNORD115-36,SNORD115-37,SNORD115-38,SNORD115-39,SNORD115-40,SNORD115-41,SNORD115-44,SNORD116-28,SNORD116-29,SNORD115-48,SNORD115-24,SNORD115-27,SNORD115-28,SNORD115-45,SNORD115-47,LOC100128714,HERC2P7,GOLGA8F,GOLGA8DP,LOC100288615,LOC100288637,LOC100289656,MIR4509-1,MIR4509-2,MIR4508,MIR4715
12q24.33 1.40E-14 1.24E-10 chr12:131692956-133851895 GOLGA3,MMP17,POLE,PXMP2,SFSWAP,ZNF10,ZNF26,ZNF84,ZNF140,ULK1,ZNF268,P2RX2,ANKLE2,GALNT9,CHFR,EP400,FBRSL1,NOC4L,PUS1,PGAM5,DDX51,EP400NL,LOC647589,SNORA49,LOC100130238,ZNF605,LOC100507055
10q26.3 7.21E-15 2.09E-10 chr10:135190263-135534747 CYP2E1,DUX4,DUX2,MTG1,SYCE1,PAOX,SPRNP1,FRG2B,SPRN,LOC619207,DUX4L7,DUX4L6,DUX4L5,DUX4L2
6q21 4.61E-10 4.56E-10 chr6:86319089-117076132 hsa-mir-587,hsa-mir-2113,AIM1,AMD1,PRDM1,CCNC,CGA,CNR1,COL10A1,EPHA7,FOXO3,FRK,FYN,GABRR1,GABRR2,GPR6,GRIK2,HDAC2,HTR1E,KPNA5,LAMA4,MARCKS,POU3F2,PREP,REV3L,SIM1,SMPD2,MAP3K7,NR2E1,TSPYL1,DDO,SNX3,RNGTT,CD164,WISP3,WASF1,FHL5,ATG5,ZBTB24,FIG4,CASP8AP2,SYNCRIP,SLC35A1,FUT9,TRAF3IP2,PNRC1,ASCC3,BVES,SEC63,ANKRD6,ZNF292,CDK19,MDN1,TSPYL4,UFL1,ORC3,PNISR,FBXL4,SNORD50A,SESN1,OSTM1,NDUFAF4,DSE,TUBE1,C6orf203,CDC40,RWDD1,UBE2J1,COQ3,SOBP,AKIRIN2,QRSL1,AKIRIN2-AS1,RARS2,PDSS2,C6orf162,LYRM2,HACE1,BEND3,RRAGD,PRDM13,BACH2,C6orf164,POPDC3,MICAL1,MANEA,GPR63,SPACA1,ARMC2,RPF2,MCHR2,FAXC,GJA10,RTN4IP1,USP45,SLC22A16,KIAA1919,GTF3C6,KLHL32,SLC16A10,PM20D2,SRSF12,C6orf165,BVES-AS1,C6orf163,CCDC162P,AKD1,NT5DC1,FAM26D,ZUFSP,HS3ST5,LACE1,MMS22L,FAM26E,SCML4,CEP57L1,PPIL6,LOC285758,FLJ34503,RSPH4A,GJB7,SNHG5,LINC00222,LIN28B,FAM26F,GSTM2P1,RFPL4B,C6orf225,TSG1,TRAF3IP2-AS1,SNORD50B,LOC728012,TPI1P3,C6orf186,BET3L,LOC100130890,MIR2113,MIR548H3,LOC100422737,MIR4464,MIR4643
8p21.2 1.01E-09 1.78E-09 chr8:25896447-26250295 PPP2R2A
2q34 1.16E-36 3.24E-09 chr2:211542637-214143899 ERBB4,IKZF2,MIR548F2,MIR4776-1
3p26.3 6.44E-09 6.44E-09 chr3:1-3100786 CHL1,CNTN6,CNTN4
3p12.2 1.29E-21 1.22E-07 chr3:75363575-86988125 GBE1,ROBO1,ROBO2,CADM2,LOC401074,LOC440970,FLJ20518,FAM86DP,ZNF717,FRG2C,MIR1324,MIR4273
14q24.1 1.86E-08 1.38E-07 chr14:68275375-69288431 ZFP36L1,RAD51B
11q23.1 6.09E-21 5.31E-07 chr11:105849158-117024891 ACAT1,APOA1,APOA4,APOC3,ATM,CRYAB,DDX10,DLAT,DRD2,FDX1,GUCY1A2,HSPB2,HTR3A,IL18,NCAM1,NNMT,NPAT,POU2AF1,PPP2R1B,PTS,RDX,SDHD,SLN,ZBTB16,CUL5,ZNF259,HTR3B,ZW10,RBM7,EXPH5,SIK2,SIK3,CADM1,REXO2,TIMM8B,C11orf71,SLC35F2,RAB39A,BTG4,FAM55D,TTC12,C11orf57,ELMOD1,TEX12,ARHGAP20,USP28,AASDHPPT,C11orf1,ALG9,TMPRSS5,BCO2,KIAA1826,BUD13,DIXDC1,ZC3H12C,ALKBH8,FDXACB1,C11orf52,APOA5,C11orf93,PIH1D2,FAM55A,FAM55B,KBTBD3,CWF19L2,KDELC2,LAYN,C11orf65,ANKK1,LOC283143,C11orf53,C11orf34,C11orf87,C11orf92,C11orf88,MIR34B,MIR34C,LOC643923,CLDN25,LOC100132078,LOC100288346,MIR4301,HSPB2-C11orf52,MIR4491
7q31.1 4.03E-07 5.74E-07 chr7:109599468-111366370 LRRN3,IMMP2L
1p31.1 1.92E-10 7.25E-07 chr1:71699756-74522473 NEGR1,NEGR1-IT1
17q21.31 4.31E-11 7.25E-07 chr17:41178765-41336147 BRCA1,NBR2
9q34.3 8.73E-06 8.73E-06 chr9:135441810-139646221 ABO,CEL,CELP,COL5A1,DBH,SARDH,FCN1,FCN2,LCN1,NOTCH1,PAEP,RALGDS,RPL7A,RXRA,SNAPC4,SURF1,SURF2,SURF4,MED22,SURF6,TSC1,VAV2,BRD3,LHX3,GFI1B,GTF3C5,GTF3C4,ADAMTSL2,PPP1R26,SEC16A,UBAC1,OLFM1,AGPAT2,SDCCAG3,WDR5,C9orf9,ADAMTS13,C9orf7,SLC2A6,PMPCA,GPSM1,DKFZP434A062,GBGT1,SNORD36C,SNORD36B,SNORD36A,SNORD24,OBP2B,OBP2A,MRPS2,EGFL7,INPP5E,BARHL1,REXO4,KCNT1,CARD9,DDX31,SNHG7,C9orf69,NACC2,C9orf116,FAM69B,CAMSAP1,C9orf163,LCN6,AK8,C9orf96,QSOX2,LINC00094,GLT6D1,TMEM8C,LCN9,LOC401557,SOHLH1,MIR126,LCN10,FAM163B,SNORA17,SNORA43,DNLZ,LOC100128593,LOC100130954,RNU6ATAC,MIR3689A,MIR3689B,LOC100506599,MIR3689D1,MIR3689F,MIR4669,MIR4673,MIR4674,MIR3689C,MIR3689D2,MIR3689E
12q23.1 5.27E-08 8.73E-06 chr12:99124001-100431272 ANKS1B,FAM71C
Xp21.2 5.11E-05 5.15E-05 chrX:30865118-34644819 hsa-mir-548f-5,DMD,FTHL17,FAM47A
10p15.3 7.17E-05 7.12E-05 chr10:1-857150 ZMYND11,DIP2C,TUBB8,C10orf108
10q11.23 6.80E-05 9.79E-05 chr10:52644085-54061437 PRKG1,CSTF2T,MIR605
17q25.3 0.00019483 0.00019271 chr17:80443432-80574531 FOXK2
1p33 1.07E-07 0.000219 chr1:48935280-50514967 BEND5,AGBL4
12p13.1 0.00036433 0.00035777 chr12:12710990-12966966 CDKN1B,CREBL2,GPR19,APOLD1,MIR61
14q32.33 9.45E-05 0.00074358 chr14:94381429-107349540 hsa-mir-544,hsa-mir-370,hsa-mir-342,SERPINA3,AKT1,BDKRB1,BDKRB2,SERPINA6,CKB,CRIP1,CRIP2,DIO3,DYNC1H1,EIF5,ELK2AP,EML1,BRF1,HSP90AA1,IFI27,JAG2,KLC1,MARK3,SERPINA5,SERPINA1,SERPINA4,PPP2R5C,MOK,TNFAIP2,TRAF3,VRK1,WARS,XRCC3,YY1,TCL1A,ADAM6,DLK1,CCNK,MTA1,BAG5,C14orf2,CDC42BPB,TCL1B,KIAA0125,TECPR2,SIVA1,CYP46A1,PAPOLA,RCOR1,PACS2,PPP1R13B,DICER1,KIF26A,TCL6,GPR132,SERPINA10,GLRX5,EVL,C14orf129,CINP,ASB2,CDCA4,ATG2B,MEG3,ZNF839,C14orf132,DDX24,BEGAIN,PPP4R4,DIO3OS,INF2,BCL11B,OTUB2,ZFYVE21,MEG8,WDR25,LINC00341,CLMN,TMEM121,AMN,IFI27L2,SETD3,APOPT1,HHIPL1,FAM181A,BTBD6,EXOC3L4,WDR20,AHNAK2,TRMT61A,TDRD9,ANKRD9,AK7,IFI27L1,C14orf79,PLD4,ADSSL1,SLC25A29,DEGS2,LINC00239,LOC145216,GSC,SERPINA12,C14orf49,MGC23270,NUDT14,LINC00521,SERPINA11,SNHG10,C14orf177,SLC25A47,LINC00523,KIAA0284,C14orf80,CCDC85C,SERPINA9,LINC00226,LINC00221,ASPG,SERPINA13,C14orf64,RTL1,TMEM179,DICER1-AS1,C14orf180,MIR127,MIR134,MIR136,MIR154,MIR203,MIR299,MIR323A,MIR337,MIR345,MIR376C,MIR369,MIR376A1,MIR377,MIR379,MIR380,MIR381,MIR382,MIR433,MIR431,MIR329-1,MIR329-2,MIR323B,MIR409,MIR412,MIR410,MIR376B,MIR485,MIR493,MIR432,MIR494,MIR495,MIR496,MIR487A,TEX22,MIR539,MIR376A2,MIR487B,SCARNA13,SNORA28,MIR411,MIR654,MIR655,MIR656,SNORD113-1,SNORD113-2,SNORD113-4,SNORD113-5,SNORD113-6,SNORD113-7,SNORD113-9,SNORD114-1,SNORD114-2,SNORD114-3,SNORD114-4,SNORD114-5,SNORD114-6,SNORD114-7,SNORD114-8,SNORD114-9,SNORD114-10,SNORD114-11,SNORD114-12,SNORD114-13,SNORD114-14,SNORD114-15,SNORD114-16,SNORD114-17,SNORD114-18,SNORD114-19,SNORD114-20,SNORD114-21,SNORD114-22,SNORD114-23,SNORD114-24,SNORD114-25,SNORD114-26,SNORD114-27,SNORD114-28,SNORD114-29,SNORD114-30,SNORD114-31,MIR758,MIR668,MIR770,MIR300,MIR541,MIR665,MIR543,MIR889,ZBTB42,LOC100129345,LOC100131366,MIR1247,MIR1185-1,MIR1185-2,MIR1197,MIR1193,MIR4309,MIR3173,LOC100507043,MIR3545,MIR4710,MIR2392
14q11.2 0.0010181 0.0010181 chr14:1-30047530 hsa-mir-3171,hsa-mir-1201,ANG,APEX1,BCL2L2,CEBPE,CMA1,LTB4R,CTSG,DAD1,FOXG1,GZMH,GZMB,HNRNPC,MMP14,MYH6,MYH7,NEDD8,NFATC4,NOVA1,PNP,NRL,OXA1L,PCK2,PSMB5,PSME1,PSME2,RABGGTA,RNASE1,RNASE2,RNASE3,RNASE4,RNASE6,SALL2,TEP1,TGM1,PABPN1,AP1G2,SLC7A7,CPNE6,TOX4,REC8,PARP2,DHRS2,EFS,IRF9,PRMT5,TM9SF1,EDDM3A,DHRS4,RIPK3,SUPT16H,ACIN1,KHNYN,SLC7A8,NGDN,LRP10,TINF2,OR10G3,OR10G2,OR4E2,CIDEB,CHMP4A,STXBP6,SLC39A2,FAM158A,ZNF219,GMPR2,SLC22A17,HAUS4,C14orf119,RNF31,RBM23,C14orf167,OSGEP,ARHGEF40,METTL3,LTB4R2,SDR39U1,RPGRIP1,NDRG2,NYNRIN,HOMEZ,CHD8,CCNB1IP1,C14orf93,ABHD4,EDDM3B,CDH24,METTL17,IL25,THTPA,OR4K5,OR11H2,OR4K1,IPO4,DCAF11,OR4K15,JPH4,RNASE7,RAB2B,AJUBA,ZFHX2,RPPH1,LRRC16B,PPP1R3E,TMEM55B,TTC5,DHRS1,CMTM5,RNASE11,TPPP2,RNASE8,MRPL52,PSMB11,OR4K14,OR4L1,OR11H6,KLHL33,MDP1,FITM1,REM2,C14orf21,ADCY4,LOC283624,TSSK4,DHRS4L2,SNORD8,RNASE10,OR6S1,C14orf23,OR4N2,OR4K2,OR4K13,OR4K17,OR4N5,OR11G2,OR11H4,RNASE9,OR5AU1,POTEG,MIR208A,C14orf165,OR11H12,RNASE13,OR4Q3,OR4M1,RNASE12,POTEM,LOC642426,ECRP,C14orf176,CBLN3,SNORD9,DHRS4L1,SNORD126,MIR208B,MIR4307,LOC100505967,NEDD8-MDP1,BCL2L2-PABPN1,MIR4707
2p25.3 0.0011137 0.0011137 chr2:1-20072169 hsa-mir-548s,ACP1,DDX1,E2F6,HPCAL1,ID2,KCNF1,KCNS3,MYCN,ODC1,RPS7,RRM2,SOX11,ADAM17,TPO,TSSC1,VSNL1,PXDN,KLF11,ASAP2,TAF1B,ITGB1BP1,ROCK2,GREB1,RNF144A,PDIA6,MYCNOS,YWHAQ,MYT1L,LPIN1,NTSR2,SH3YL1,TRIB2,GRHL1,TRAPPC12,NBAS,CPSF3,SNTG2,ADI1,ALLC,KIDINS220,RDH14,COLEC11,SMC6,NOL10,FAM49A,RSAD2,NT5C1B,CMPK2,MBOAT2,TMEM18,OSR1,C2orf50,PQLC3,LOC150622,FAM84A,CYS1,ATP6V1C2,RNASEH1,FAM150B,IAH1,FLJ33534,LOC339788,LINC00299,LOC339822,MSGN1,GEN1,C2orf48,LOC386597,LOC400940,LINC00487,FAM110C,LOC727982,RAD51AP2,LOC730811,SNORA80B,MIR4261,MIR3125,MIR4262,LOC100505964,LOC100506054,LOC100506274,LOC100506474,NT5C1B-RDH14,MIR4757,MIR4429
5q35.3 0.0028515 0.0028515 chr5:153840473-180915260 hsa-mir-1271,hsa-mir-1303,ADRA1B,BNIP1,CANX,CCNG1,CLTB,NKX2-5,DBN1,DOCK2,DRD1,DUSP1,EBF1,F12,FABP6,FGFR4,FOXI1,FLT4,GABRA1,GABRA6,GABRB2,GABRG2,GABRP,GRK6,GRM6,HK3,HMMR,HNRNPAB,HNRNPH1,HRH2,IL12B,ITK,KCNMB1,LCP2,LTC4S,MGAT1,MSX2,NPM1,MAPK9,PROP1,RARS,SGCD,SLC34A1,SLIT3,SNCB,STK10,ZNF354A,TTC1,STC2,ADAM19,FGF18,SQSTM1,ATP6V0E1,PTTG1,PDLIM7,CNOT8,HAND1,MED7,ADAMTS2,CLINT1,MAML1,GFPT2,GNB2L1,SLU7,RGS14,CPLX2,C5orf4,BTNL3,LMAN2,SOX30,MGAT4B,B4GALT7,RNF44,TBC1D9B,ATP10B,N4BP3,FAF2,WWC1,FBXW11,LARP1,ZNF346,GEMIN5,TSPAN17,OR4F3,HAVCR1,CYFIP2,PRELID1,MAT2B,MRPL22,TLX3,KCNIP1,ZNF354C,RPL26L1,C5orf45,DDX41,NOP16,HMP19,UIMC1,RAB24,NEURL1B,FAM193B,TMED9,CDHR2,CCDC99,THG1L,NHP2,RNF130,KIAA1191,ERGIC1,CLK4,ODZ2,CNOT6,C5orf54,NSD1,GMCL1P1,RMND5B,RANBP17,CCNJL,PANK3,BTNL8,DOK3,ZFP2,RUFY1,CPEB4,PRR7,TRIM7,MXD3,THOC3,TRIM52,HAVCR2,AGXT2L2,UNC5A,TRIM41,BOD1,COL23A1,TIMD4,UBTD2,SCGB3A1,SFXN1,GPRIN1,PWWP2A,C1QTNF2,ZNF354B,C5orf47,C5orf58,OR2Y1,LSM11,NUDCD2,UBLCP1,C5orf41,BTNL9,PPP1R2P3,FAM71B,RNF145,HIGD2A,FAM153B,LOC202181,EIF4E1B,RASGEF1C,LOC257358,EFCAB9,SH3PXD2B,LOC285593,FAM153A,ARL10,LOC285626,LOC285627,LOC285629,KIF4B,OR2V2,ZNF454,C5orf60,LOC340037,PFN3,ZNF879,FBLL1,NIPAL4,C5orf25,MIR103A1,MIR146A,MIR218-2,FNDC9,FLJ16171,MIR340,SNORD95,SNORD96A,LOC643201,ZFP62,CBY3,FAM153C,SNORA74B,MIR585,LOC728554,AACSP1,LOC729678,OR4F29,FAM196B,LOC100132062,LOC100132287,C5orf52,LOC100268168,MIR1229,MIR103B1,MIR3142,MIR3141,MIR4281,MIR3912,LOC100507387,MIR4634,MIR4638,MIR378E,LOC100859930
21q22.3 0.012351 0.012227 chr21:46230687-46306160 PTTG1IP
22q11.1 0.020332 0.020332 chr22:1-17960585 IL17RA,ANKRD62P1-PARP4P3,POTEH,HSFY1P1,CECR6,CECR5,CECR3,CECR1,OR11H1,GAB4,CCT8L2,XKR3,TPTEP1,CECR7,CECR5-AS1
18q21.2 6.39E-06 0.036866 chr18:48472083-48920689 SMAD4,MEX3C,ELAC1
17p13.3 0.040633 0.040814 chr17:1-1180022 ABR,DOC2B,RPH3AL,TIMM22,GEMIN4,GLOD4,RNMTL1,VPS53,NXN,FAM57A,FAM101B,C17orf97,BHLHA9,DBIL5P,MIR3183,LOC100506388
4p16.3 0.056345 0.056345 chr4:1-1243876 hsa-mir-571,ATP5I,CTBP1,DGKQ,GAK,IDUA,MYL5,PDE6B,ZNF141,PCGF3,SPON2,CPLX1,SLC26A1,FGFRL1,PIGG,ABCA11P,MFSD7,TMEM175,ZNF595,ZNF721,ZNF718,RNF212,ZNF876P,ZNF732,LOC100129917,LOC100130872,TMED11P
9p21.2 4.44E-25 0.091742 chr9:27572512-28982153 LINGO2,MIR876,MIR873
10q25.1 7.54E-17 0.11879 chr10:99340084-113910615 hsa-mir-548e,hsa-mir-3158-2,ADD3,ADRA2A,ARL3,CHUK,ABCC2,COL17A1,COX15,CPN1,CYP17A1,DUSP5,FGF8,GOT1,TLX1,HPS1,MXI1,NDUFB8,NFKB2,PAX2,PITX3,PSD,SCD,SFRP5,FBXW4,TAF5,WNT8B,XPNPEP1,SHOC2,GBF1,LDB1,BTRC,PKD2L1,INA,SMC3,NEURL,NOLC1,GSTO1,SH3PXD2A,SLK,ACTR1A,SMNDC1,NPM3,ERLIN1,LBX1,MGEA5,NT5C2,PDCD11,SORCS3,PPRC1,DNMBP,DPCD,SEC31B,CNNM1,PDCD4,C10orf28,POLL,KCNIP2,CALHM2,CUTC,SUFU,CNNM2,C10orf26,CRTAC1,CWF19L1,PI4K2A,HIF1AN,FAM178A,C10orf2,ENTPD7,AS3MT,SEMA4G,AVPI1,HPSE2,CUEDC2,FBXL15,C10orf76,HPS6,TMEM180,C10orf95,PDZD7,OBFC1,WDR96,TRIM8,KAZALD1,SFXN3,SLC25A28,ELOVL3,MARVELD1,PCGF6,LOXL4,LZTS2,MRPL43,PYROXD2,USMG5,ITPRIP,LINC00263,BBIP1,HOGA1,SORCS1,MORN4,ZFYVE27,SFXN2,C10orf32,GSTO2,SFR1,CALHM3,NKX2-3,CCDC147,CALHM1,BLOC1S2,RBM20,LOC282997,FLJ41350,GOLGA7B,C10orf62,MIR146B,RPL13AP6,SNORA12,MIR608,MIR609,LOC729020,TLX1NB,MIR936,DNMBP-AS1,LOC100289509,MIR1287,MIR1307,MIR3158-1,MIR3158-2,LOC100505761,LOC100505839,LOC100505933,C10orf32-AS3MT,MIR4680,MIR4482-1,MIR4685
1q44 0.15417 0.15417 chr1:245282267-247110824 AHCTF1,SCCPDH,KIF26B,TFB2M,SMYD3,LOC149134,CNST,LOC255654
8p11.21 0.1289 0.17382 chr8:42883855-47753079 FNTA,SGK196,HGSNAT,POTEA
Xp22.33 0.21375 0.21462 chrX:1-11137490 SLC25A6,SHROOM2,STS,ARSD,ARSE,ARSF,ASMT,CLCN4,CSF2RA,IL3RA,KAL1,CD99,MID1,GPR143,PRKX,SHOX,TBL1X,XG,GTPBP6,HDHD1,AKAP17A,PNPLA4,ASMTL,GYG2,ZBED1,MXRA5,VCX,PPP2R3B,VCX2,VCX3A,PLCXD1,WWC3,NLGN4X,CRLF2,ASMTL-AS1,FAM9A,FAM9B,DHRSX,PPP2R3B-AS1,P2RY8,ARSH,LOC389906,CD99P1,VCX3B,MIR651,CXorf28,XGPY2,LOC100288814,LINC00102,MIR3690,MIR4770,MIR4767