There are 80 participants in these data.
HNDid DOB Age0 Age0grp Age0med Sex Race PovStat
Min. :8031107802 Min. :1945-12-28 Min. :50.0 30-34: 0 Below: 0 Women:80 White:40 Above:57
1st Qu.:8139538326 1st Qu.:1949-01-04 1st Qu.:53.0 35-39: 0 Above:80 Men : 0 AfrAm:40 Below:23
Median :8154425602 Median :1951-03-30 Median :55.0 40-44: 0
Mean :8163593397 Mean :1951-06-25 Mean :54.8 45-49: 0
3rd Qu.:8191917627 3rd Qu.:1953-11-17 3rd Qu.:57.0 50-54:37
Max. :8223284501 Max. :1957-07-05 Max. :59.0 55-59:43
60-64: 0
Hyperten Smoker drawDate DRUnumber miR.30c.5p miR.20a.5p miR.4763.5p
No :39 Never:80 Min. :2004-10-16 Min. : 93 Min. : 0.148 Min. : 0.088 Min. : 0.012
Yes:41 Ever : 0 1st Qu.:2005-11-03 1st Qu.: 722 1st Qu.: 0.545 1st Qu.: 0.468 1st Qu.: 0.611
Median :2006-12-09 Median :1226 Median : 0.729 Median : 0.815 Median : 1.365
Mean :2006-11-04 Mean :1238 Mean : 1.667 Mean : 1.752 Mean : 2.014
3rd Qu.:2007-09-21 3rd Qu.:1708 3rd Qu.: 1.632 3rd Qu.: 2.056 3rd Qu.: 2.308
Max. :2008-12-18 Max. :2460 Max. :15.499 Max. :10.611 Max. :18.274
miR.103a.2.5p CMVplus PhysBMI Chol HDL LDLcalc Triglyc CRP
Min. :0.000 No : 8 Min. :20.1 Min. :114 Min. :30.0 Min. : 15.8 Min. : 39.0 Min. : 0.15
1st Qu.:0.202 Yes :31 1st Qu.:26.8 1st Qu.:176 1st Qu.:45.8 1st Qu.: 99.6 1st Qu.: 74.8 1st Qu.: 1.22
Median :0.388 NA's:41 Median :30.5 Median :197 Median :54.5 Median :116.6 Median : 98.0 Median : 3.45
Mean :0.433 Mean :31.7 Mean :198 Mean :56.3 Mean :116.3 Mean : 125.5 Mean : 6.66
3rd Qu.:0.655 3rd Qu.:35.8 3rd Qu.:214 3rd Qu.:65.0 3rd Qu.:131.8 3rd Qu.: 127.0 3rd Qu.: 7.67
Max. :0.992 Max. :54.6 Max. :363 Max. :92.0 Max. :226.0 Max. :1110.0 Max. :48.70
NA's :2
heartDis Menopause rxHRT BPdia BPsys PhysRespRate PhysPulseRadial rxHypercholesterolemia
No :74 No : 6 No :76 Min. :50.0 Min. : 93 Min. :12.0 Min. : 56.0 Min. :0.000
Yes : 3 Yes :69 Yes : 2 1st Qu.:66.8 1st Qu.:111 1st Qu.:12.0 1st Qu.: 66.0 1st Qu.:0.000
NA's: 3 NA's: 5 NA's: 2 Median :73.0 Median :120 Median :16.0 Median : 72.0 Median :0.000
Mean :72.3 Mean :123 Mean :15.4 Mean : 73.4 Mean :0.179
3rd Qu.:78.0 3rd Qu.:130 3rd Qu.:16.0 3rd Qu.: 78.0 3rd Qu.:0.000
Max. :96.0 Max. :171 Max. :20.0 Max. :100.0 Max. :1.000
NA's :4 NA's :3 NA's :4 NA's :5 NA's :2
Perform regression of expression levels on race, poverty status, age, and selected interactions.
(1) All interactions
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.050 0.114 0.091 0.108
RaceAfrAm -2.064 -6.528 -5.252 -1.611
PovStatBelow 5.502 -3.129 31.453 -5.575 *
Age0 -0.018 0.015 0.073 -0.026
RaceAfrAm:PovStatBelow -14.805 -8.233 -9.526 3.538
RaceAfrAm:Age0 0.050 0.142 0.111 0.029
PovStatBelow:Age0 -0.095 0.066 -0.569 0.102 *
RaceAfrAm:PovStatBelow:Age0 0.241 0.118 0.153 -0.064
(2) Eliminate 3-way because none of them were significant
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.046 0.112 0.089 0.091
RaceAfrAm -5.614 -8.275 -7.511 -0.662
PovStatBelow -1.281 -6.467 27.137 * -3.761 *
Age0 -0.050 0.000 0.053 -0.018
RaceAfrAm:PovStatBelow -1.563 -1.717 -1.100 -0.003
RaceAfrAm:Age0 0.115 0.174 0.153 0.012
PovStatBelow:Age0 0.028 0.127 -0.491 * 0.069 *
(3) Analyze just main effects and significant interactions
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.018 0.070 0.074 0.087
RaceAfrAm 0.263 0.786 0.541 0.002
PovStatBelow -3.175 -8.652 25.647 * -3.791 *
Age0 0.006 0.084 0.127 -0.012
PovStatBelow:Age0 0.046 0.149 -0.475 * 0.069 *
(4) Add covariates to (3)
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.022 0.083 0.102 0.106
RaceAfrAm 0.276 0.872 0.385 0.024
PovStatBelow -3.247 -10.527 26.907 * -4.249 **
Age0 0.016 0.097 0.150 -0.012
HypertenYes -0.212 -0.329 -0.503 -0.007
PhysBMI 0.020 0.033 -0.032 0.004
Chol -0.000 0.003 -0.006 0.001
PovStatBelow:Age0 0.047 0.183 -0.497 * 0.078 **
There are differences in miR.4763.5p and miR.103a.2.5p associated with poverty status and its interaction with age, but no significant effects for miR.30c.5p and miR.20a.5p.
These plots illustrate the direction of the effects.
An outlier is apparent in the analyses for miR.4763.5p that may be responsible for the significant effects. Excluding the potential outlier makes little difference in the results when the 4 regressions were re-run.
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.048 0.111 0.130 0.116
RaceAfrAm -1.592 -6.937 12.582 -2.140
PovStatBelow 5.502 -3.129 31.453 * -5.575 **
Age0 -0.018 0.015 0.073 -0.026
RaceAfrAm:PovStatBelow -15.277 -7.824 -27.360 4.067
RaceAfrAm:Age0 0.041 0.150 -0.226 0.040
PovStatBelow:Age0 -0.095 0.066 -0.569 * 0.102 **
RaceAfrAm:PovStatBelow:Age0 0.249 0.111 0.491 -0.074
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.043 0.110 0.100 0.092
RaceAfrAm -5.403 -8.627 5.084 -1.004
PovStatBelow -1.437 -6.206 17.801 * -3.508 *
Age0 -0.050 0.001 0.010 -0.017
RaceAfrAm:PovStatBelow -1.550 -1.738 -0.354 -0.023
RaceAfrAm:Age0 0.111 0.181 -0.089 0.019
PovStatBelow:Age0 0.030 0.122 -0.322 * 0.064 *
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.017 0.067 0.093 0.084
RaceAfrAm 0.242 0.780 0.107 0.013
PovStatBelow -3.554 -8.766 17.697 * -3.596 *
Age0 -0.001 0.082 -0.031 -0.008
PovStatBelow:Age0 0.054 0.152 -0.323 * 0.065 *
miR.30c.5p miR.20a.5p miR.4763.5p miR.103a.2.5p
Rsq 0.021 0.080 0.104 0.101
RaceAfrAm 0.259 0.867 0.026 0.033
PovStatBelow -3.605 -10.635 19.161 * -4.066 *
Age0 0.008 0.094 -0.030 -0.008
HypertenYes -0.186 -0.321 0.056 -0.021
PhysBMI 0.021 0.033 -0.024 0.004
Chol 0.000 0.003 -0.003 0.001
PovStatBelow:Age0 0.054 0.185 -0.350 * 0.074 *