class: center, middle 
# Contextualizing Sensitivity Analysis in Observational Studies

Lucy D'Agostino McGowan  
Robert A Greevy, Jr

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## data

 
 
 Right Heart Catheterization

30-day Mortality

50 Covariates
.footnote[Connors, A F, T Speroff, N V Dawson, and C Thomas. 1996. "The effectiveness of right heart catheterization in the initial care of critically III patients. Jama.]
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.footnote[Lucy D'Agostino McGowan \#JSM2017]
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## recommended components

Include content-matter expertise

Anchor a sensitivity analysis with your data

Calculate a hypothetical "**tipping point**" confounder

---

## recommended components

 
 
 Include content matter expertise

Anchor a sensitivity analysis with your data

Calculate a hypothetical "**tipping point**" confounder

---

Anchor a sensitivity analysis with your data

Calculate a hypothetical "**tipping point**" confounder

---

Anchor a sensitivity analysis with your data

Calculate a hypothetical ["**tipping point**"](http://rpubs.com/lucymcgowan/enar2017) confounder

```r
devtools::install_github("LucyMcGowan/tipr")
tip_with_binary(p1 = .5, p0 = 0, lb = 1.2, ub = 1.5)
```
---

## anchor your sensitivity analysis

Imbalance of **exposure**

Predictive of **outcome**

Independent of **other covariates**

---

## anchor your sensitivity analysis

Imbalance of **exposure**

Predictive of **outcome**

Independent of **other covariates**
---
![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.001.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.002.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.003.png)
---

## anchor your sensitivity analysis

Imbalance of **exposure**

Predictive of **outcome**

Independent of **other covariates**
---
![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.004.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.005.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.006.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.007.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.008.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.005.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.009.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.010.png)
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![](https://raw.githubusercontent.com/LucyMcGowan/talks/master/2017-08_jsm/img/keynote/keynote.011.png)
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## Lucy D'Agostino McGowan

 
 
 Poster #34 Baltimore Convention Center Halls A&B 10:30a

[http://rpubs.com/lucymcgowan/jsm2017_poster](http://rpubs.com/lucymcgowan/jsm2017_poster)

[http://rpubs.com/lucymcgowan/jsm2017](http://rpubs.com/lucymcgowan/jsm2017)

[@LucyStats](https://twitter.com/LucyStats)

.footnote[Slides created via the R package [**xaringan**](https://github.com/yihui/xaringan).]