Current nationally reportable major congenital anomalies (N=47)
| Defect | 2004-2008* | 2005-2009* | 2006-2010* | 2007-2011 | 2008-2012 | p-value |
|---|---|---|---|---|---|---|
| Cardiovascular | ||||||
| Aortic valve stenosis | 1.3 | - | 1.1 | 1.4 | 2.0 | 0.3027 |
| Atrail spetal defect | 139.2 | 148.6 | 157.4 | 158.0 | 160.2 | 0.0256 |
| Atrioventricular septal defect | 5.4 | 6.2 | 6.1 | 7.3 | 6.4 | 0.1779 |
| Coarctation of the aorta | 5.4 | 4.6 | 5.4 | 5.3 | 4.4 | 0.5386 |
| Common truncus | 2.0 | 2.2 | 1.8 | 2.5 | 2.8 | 0.1439 |
| Double outlet right ventricle | - | - | - | 2.1 | 1.8 | - |
| Ebstein anomaly | - | - | 1.4 | 1.2 | 1.6 | 0.6893 |
| Hypoplastic left heart syndrome | 2.6 | 2.6 | 2.7 | 2.0 | 1.2 | 0.0922 |
| Inerrupted aortic arch | - | - | - | 4.3 | 4.4 | - |
| Pulmonary valve atresia and stenosis | 13.9 | 14.6 | 15.1 | 14.4 | 14.0 | 0.9832 |
| Single ventricle | - | - | - | 1.4 | 0.9 | - |
| Teratology of fallot | 5.9 | 5.5 | 5.6 | 6.0 | 5.3 | 0.5854 |
| Total anomalous pulmonary venous connection | - | 2.0 | 2.2 | 1.8 | 1.8 | 0.2496 |
| Transposition of the great arteries | 4.6 | 4.4 | 4.7 | 4.6 | 3.7 | 0.2631 |
| Tricuspid valve atresia and stenosis | 1.9 | 1.6 | 1.1 | 1.1 | - | 0.0530 |
| Ventricular septal defect | 98.7 | 102.0 | 99.1 | 101.9 | 101.2 | 0.3909 |
| Central Nervous System | ||||||
| Anencephalus | - | - | 2.0 | 2.5 | 2.1 | 0.8086 |
| Spina bifida without anencephalus | 7.6 | 6.4 | 5.6 | 3.7 | 2.7 | 0.0045 |
| Encephalocele | 4.8 | 4.4 | 4.1 | 3.2 | 2.8 | 0.0051 |
| Holoprosencephaly | - | - | - | 9.2 | 10.1 | - |
| Chromosomal | ||||||
| Deletion 22 q11 | - | - | - | 0.9 | - | - |
| Trisomy 13 | 1.5 | 1.5 | 1.3 | 1.2 | 1.6 | 0.9765 |
| Trisomy 18 | 2.2 | 2.2 | 1.8 | 2.1 | 2.1 | 0.7222 |
| Trisomy 21 (Down syndrome) | 15.8 | 15.9 | 15.6 | 16.2 | 17.8 | 0.1228 |
| Turner syndrome* | - | - | - | - | 2.6 | - |
| Ear | ||||||
| Anotia / microtia | 2.2 | 3.3 | 3.9 | 3.7 | 4.1 | 0.0730 |
| Eye | ||||||
| Anophthalmia / microphthalmia | 4.1 | 2.7 | 2.0 | 1.4 | 1.6 | 0.0135 |
| Congenital cataract | 5.2 | 5.5 | 5.7 | 5.2 | 5.5 | 0.7660 |
| Gastrointestinal | ||||||
| Biliary atresia | 3.0 | 2.9 | 3.2 | 2.3 | 2.5 | 0.2249 |
| Esophageal atresia / tracheoesophageal fistula | 2.6 | 2.9 | 2.7 | 2.7 | 2.7 | 0.7821 |
| Rectal and large intestinal atresia / stenosis | 8.9 | 9.5 | 10.4 | 10.5 | 9.9 | 0.1631 |
| Small intestinal atresia / stenosis | - | - | - | 7.5 | 6.6 | - |
| Genitourinary | ||||||
| Bladder exstrophy | - | 1.1 | - | - | - | - |
| Cloacal exstrophy | - | - | - | - | - | - |
| Congenital posterior urethral valves | - | - | - | 7.5 | 8.7 | - |
| Hypospadias** | 99.9 | 104.6 | 105.6 | 112.6 | 113.6 | 0.0063 |
| Renal agenesis / hypoplasia | 7.2 | - | 7.5 | 7.8 | 9.1 | 0.1220 |
| Musculoskeletal | ||||||
| Clubfoot | - | - | - | 35.8 | 36.9 | - |
| Craniosynostosis | - | - | - | - | - | - |
| Diaphragmatic hernia | 6.3 | 6.6 | 5.7 | 5.7 | 5.5 | 0.0534 |
| Gastroschisis | - | - | - | 3.9 | 5.2 | - |
| Limb deficiencies | - | - | - | 11.9 | 11.7 | - |
| Omphalocele | - | - | - | 13.9 | 12.4 | - |
| Orofacial | ||||||
| Choanal atresia | 2.6 | 2.2 | 2.7 | 3.0 | 3.2 | 0.0916 |
| Cleft lip with celft palate | - | - | - | 7.8 | 8.7 | - |
| Cleft lip alone | - | - | - | 4.1 | 3.9 | - |
| Cleft palate alone | 17.7 | 15.3 | 17.7 | 14.1 | 13.1 | 0.1220 |
|
Ref: 95% CI = 95% Confidence Interval; g = grams *per 10,000 live female births **per 10,000 live male births |
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Table Notes:
Missing data is the result of suppression and/or non-data collection in early years.
Five-year estimates are based on historical estimates reported to the National Birth Defects Prevention Network. Although p-value estimates are provided to assess the trend (increasing or decreasing) over time, caution should be used in interpretation as data collection methods and data aggregation may vary leading to systematic differences. Further, from the 2007-2011 estimate and on reports are only included if reported before the age of three years. For conditions that tend to have a later diagnosis and reporting estimates in the more recent years may be systematically lower.
The p-value estimates the probability that the observed slope is different from a slope of zero. By convention an alpha of 0.05 is used to determine significance; p-values are only calculated for defects with 3 or more data points. The p-value estimate is calculated to model the observed rates over time using a generalized linear model with a Poisson distribution and offset of the natural log (ln) of the birth population size under the form:
\[ ln \frac a n = \beta_0 + \beta_1 X_1 + \ln(n) \]
Resources
National Birth Defects Prevention Network
Centers for Diesase Control and Prevention
Contact
Alaska Birth Defects Registry (ABDR)
3601 C Street, Suite 358
Anchorage, AK 99503
(907) 269-3400 phone
(907) 754-3529 fax
hssbirthdefreg@alaska.gov
Updated: March 16, 2017
Code source: R:\ABDR\Analysis_New\Published Data\trend04_12.Rmd