Compare Nedocromil sodium with placebo for preventing exercise-induced bronchoconstriction

Spooner, C., Saunders, L.D., Rowe, B.H.: Nedocromil sodium for preventing exercise induced bronchoconstriction. Cochrane Database Syst. Rev. (1) (2002). Art. No. CD001183. http://dx.doi.org/10.1002/14651858.CD001183

Include meta-analysis library

library (meta)
## Loading 'meta' package (version 4.7-0).
## Type 'help("meta-package")' for a brief overview.

Read data from file

author,
year of publication,
Ne, Number of patients (sample size) in the experimental treatment group,
Me, Mean response among the patients in the experimental group,
Se, Standard deviation of the response in the experimental group, and
Nc, Mc and Sc – sample size, mean response and standard deviation in the control patients.

data1 <- read.csv ("dataset01.csv", as.is = TRUE)

View data table

data1
##          author  year Ne    Me    Se Nc    Mc    Sc
## 1         Boner  1988 13 13.54 13.85 13 20.77 21.46
## 2         Boner  1989 20 15.70 13.10 20 22.70 16.47
## 3        Chudry  1987 12 21.30 13.10 12 39.70 12.90
## 4         Comis  1993 12 14.50 12.20 12 31.30 15.10
## 5  DeBenedictis 1994a 17 14.40 11.10 17 27.40 17.30
## 6  DeBenedictis 1994b  8 14.80 18.60  8 31.40 20.60
## 7  DeBenedictis  1995 13 15.70 16.80 13 29.60 18.90
## 8       Debelic  1986 12 29.83 15.95 12 48.08 15.08
## 9     Henriksen  1988 12 17.50 13.10 12 47.20 16.47
## 10        Konig  1987 12 12.00 14.60 12 26.20 12.30
## 11       Morton  1992 16 15.83 13.43 16 38.36 18.01
## 12     Novembre 1994f 24 15.42  8.35 24 28.46 13.84
## 13     Novembre 1994s 19 11.00 12.40 19 26.10 14.90
## 14        Oseid  1995 20 14.10  9.50 20 28.90 18.00
## 15      Roberts  1985  9 18.90 17.70  9 38.90 18.90
## 16         Shaw  1985  8 10.27  7.02  8 34.43 10.96
## 17       Todaro  1993 13 10.10  8.90 13 23.50  4.00

Meta-analysis

mc1 <- metacont (Ne, Me, Se, Nc, Mc, Sc, data=data1, studlab=paste(author, year))

Forest plot

forest (mc1, prediction=TRUE, col.predict="black")