PRACTICAL
Charleen D. Adams
16 January 2017
install.packages('Rserve',
repos='http://cran.r-project.org')
install.packages('MASS',
repos='http://cran.r-project.org')
install.packages('metafor',
repos='http://cran.r-project.org')
install.packages('AER',
repos='http://cran.r-project.org')
install.packages('RColorBrewer',
repos='http://cran.r-project.org')
install.packages('aod',
repos='http://cran.r-project.org')
install.packages('ggplot2',
repos='http://cran.r-project.org')
install.packages('Rcpp',
repos='http://cran.r-project.org')
install.packages('data.table',
repos='http://cran.r-project.org') # Data merging and cleaning
setwd("C:/Users/ca16591/Dropbox/Bristol") #oakfield
rm(list=ls())
data <- read.table("brainshake.txt", header=TRUE, na.strings=c("NDEF","NA","TAG"))
dim(data)
# Sort by sampleid (smallest to largest)
attach(data)
newdata <- data[order(sampleid),]
# Read in map file with subject and sampleids
map <- read.delim("Z:/data/protect/metabolomic/brainshake/released/2016-07-07/data/data.id_map.tsv")
# Read in demographics data
PCa_demo <- read.csv("C:/Users/ca16591/Dropbox/Bristol/Michael_PCa2.demo/PCa2_demo.csv")
dim(PCa_demo)
# Identify overlap in sampleids from map and PCa_demo
mydata <- merge(PCa_demo, map, by=c("subjectid"))
write.csv(mydata, "mydata.csv")
library(data.table)
mydata$subjectid <- factor(mydata$subjectid)
levels(mydata$subjectid)
test <- mydata[order(mydata$subjectid), ]
DT <- data.table(test, key = 'subjectid')
new<- do.call(rbind, lapply(split(test, test$subjectid), `[`, 1, ))
dim(new)
new2 <- as.data.frame(new)
write.csv(new2, "new2.csv")
# Merge the metabolomic data ('data') with the demographic data (new2)
metab_demo <- merge(new2, data, by=c("sampleid"))
data <- metab_demo
write.csv(data, "metabol.data.clean.demo.tsv") #I resaved this as 12-15_cleaned_met3.txt
# Look in Excel and delete extra columns from merging
# Read in cleaned data
# Counted number of columns not needed for the metabolite variables list: 26*3+12
cleaned_met3 <- read.delim("C:/Users/ca16591/Dropbox/Bristol/12-15_cleaned_met3.txt")
data <- cleaned_met3
# Create metabolite name lists for use in loops
mname=colnames(data)[-c(1:90)]
sname=scan('mininames.txt',what='')
mname=colnames(data)[-c(1:90)]
smname=mname[-c(228:230)]
# Create age variable
data$p1pccattdate2 <- as.Date(data$p1pccattdate.y)
data$p0dob.y2 <- as.Date(data$p0dob.y)
data$age <- (data$p1pccattdate2-data$p0dob.y2)/365
# Function to loop through the associations
logRegress<-function(outcome.name,metabolite.name,dataset,covariate.name=NULL,
metabolite.log='F',subset=NULL)
{
##subseting
tx=dataset
if(!is.null(subset)) {ind=with(tx,eval(parse(text=subset))); tx=tx[ind,]}
##log-transform and scaling the metabolites
logname=metabolite.name
scalename=metabolite.name
if (metabolite.log=='T') {tx=logtransform(tx,logname)}
tx[,scalename]=scale(tx[,scalename])
##logistic regression of exposure with metabolites
add=numeric()
fom=formula(paste('casecontrol.y~',paste(c('met', covariate.name),collapse='+')))
for (j in 1:length(metabolite.name))
{
met=tx[,metabolite.name[j]];
fit=glm(fom,data=tx, family="binomial")
temp=c(summary(fit)$coef['met',],confint(fit)['met',]);
add=rbind(add,temp);
}
rownames(add)=metabolite.name
add=data.frame(add,check.names = F)
add
}
result=logRegress('casecontrol.y',smname,data,covariate.name=c('age', 'centre.y'))
result$Estimate = exp(result$Estimate)
result$`2.5 %` = exp(result$`2.5 %`)
result$`97.5 %` = exp(result$`97.5 %`)
copy_result <- result
## null device
## 1PCA for multiple-testing correction
data <- cleaned_met3
mname=colnames(data)[-c(1:90)]
ncomp<-function(data,metabolite.name)
{
tx=data;
ptx=scale(tx[,metabolite.name])
pca=princomp(~.,data=data.frame(ptx),na.action=na.exclude)
var=pca$sdev^2 / sum(pca$sdev^2)
cumvar=cumsum(var)
n=which(cumvar>=0.99)[1]
n
}
ncomp(data,mname)## Comp.37
## 370.05/39## [1] 0.001282051newp <- round(0.001282051,4)
copy_result = copy_result[order(copy_result$'Pr(>|z|)'),]
head(copy_result)## Estimate Std. Error z value Pr(>|z|) 2.5 %
## Glol 0.6768921 0.05923904 -6.587605 4.469787e-11 0.6020223
## M_VLDL_PL_. 0.8741126 0.02851107 -4.719083 2.369100e-06 0.8265087
## S_HDL_C 0.8731400 0.02902072 -4.674570 2.945703e-06 0.8246227
## S_HDL_CE 0.8770255 0.02889313 -4.541538 5.584531e-06 0.8285314
## Tyr 1.1355432 0.02879179 4.414841 1.010844e-05 1.0734096
## Ile 1.1350815 0.02875469 4.406394 1.051058e-05 1.0730497
## 97.5 %
## Glol 0.7595052
## M_VLDL_PL_. 0.9242666
## S_HDL_C 0.9240081
## S_HDL_CE 0.9279242
## Tyr 1.2016918
## Ile 1.2011138copy_result$sig <- ifelse(copy_result$'Pr(>|z|)'<0.0013,"yes","no")
# List of PCa results sorted by p-value
copy_result## Estimate Std. Error z value Pr(>|z|) 2.5 %
## Glol 0.6768921 0.05923904 -6.587604711 4.469787e-11 0.6020223
## M_VLDL_PL_. 0.8741126 0.02851107 -4.719083099 2.369100e-06 0.8265087
## S_HDL_C 0.8731400 0.02902072 -4.674569930 2.945703e-06 0.8246227
## S_HDL_CE 0.8770255 0.02889313 -4.541538033 5.584531e-06 0.8285314
## Tyr 1.1355432 0.02879179 4.414840775 1.010844e-05 1.0734096
## Ile 1.1350815 0.02875469 4.406393808 1.051058e-05 1.0730497
## SFA.FA 1.1273697 0.02876072 4.168436031 3.066968e-05 1.0657474
## Leu 1.1256486 0.02885456 4.101930615 4.097171e-05 1.0639841
## M_HDL_FC_. 0.8908335 0.02914966 -3.965665805 7.319135e-05 0.8410357
## XS_VLDL_PL_. 0.8967647 0.02897095 -3.761070327 1.691878e-04 0.8469586
## XXL_VLDL_TG 1.1105930 0.02911863 3.602301891 3.154118e-04 1.0493243
## M_LDL_PL_. 1.1104049 0.02909489 3.599419363 3.189285e-04 1.0492575
## VLDL_D 1.1080266 0.02851464 3.597470302 3.213272e-04 1.0478807
## S_VLDL_TG_. 1.1059541 0.02847409 3.536844137 4.049386e-04 1.0460018
## M_HDL_FC 0.9044344 0.02848167 -3.526674007 4.208145e-04 0.8552427
## XL_VLDL_TG 1.1077416 0.02901793 3.526210333 4.215520e-04 1.0467989
## XXL_VLDL_L 1.1074178 0.02906549 3.510381605 4.474640e-04 1.0464155
## IDL_FC 0.9050898 0.02848089 -3.501333081 4.629369e-04 0.8558657
## XXL_VLDL_FC 1.1068099 0.02904131 3.494398027 4.751321e-04 1.0458895
## XXL_VLDL_PL 1.1063088 0.02905729 3.476893648 5.072590e-04 1.0453871
## XL_VLDL_P 1.1053078 0.02898962 3.453782594 5.527828e-04 1.0445477
## FAw6.FA 0.9061120 0.02861173 -3.445871923 5.692201e-04 0.8565751
## S_LDL_C_. 0.9052552 0.02893749 -3.439771466 5.822056e-04 0.8550233
## XL_VLDL_L 1.1047272 0.02898280 3.436467331 5.893534e-04 1.0440106
## M_LDL_CE_. 0.9056247 0.02897494 -3.421242777 6.233566e-04 0.8552919
## M_VLDL_TG_. 1.1020565 0.02841647 3.419776960 6.267250e-04 1.0424333
## S_LDL_CE_. 0.9060884 0.02888218 -3.414505477 6.389791e-04 0.8559354
## L_LDL_FC 0.9078318 0.02849073 -3.393951007 6.889202e-04 0.8584477
## L_VLDL_TG 1.1029099 0.02891171 3.387970725 7.041178e-04 1.0424058
## PUFA.FA 0.9080985 0.02859461 -3.371349596 7.480087e-04 0.8584902
## Val 1.1010931 0.02856868 3.370943536 7.491121e-04 1.0412454
## M_LDL_C_. 0.9071151 0.02902466 -3.358725652 7.830276e-04 0.8565744
## S_VLDL_C_. 0.9088598 0.02845679 -3.358228853 7.844364e-04 0.8594702
## S_HDL_C_. 0.9095193 0.02867740 -3.307099677 9.426734e-04 0.8596238
## S_HDL_CE_. 0.9096188 0.02866886 -3.304271557 9.522355e-04 0.8597342
## S_HDL_L 0.9077973 0.02928005 -3.303756464 9.539867e-04 0.8567168
## UnSat 0.9101088 0.02852848 -3.301650535 9.611774e-04 0.8605178
## L_VLDL_P 1.0999319 0.02887759 3.298343909 9.725694e-04 1.0396486
## XL_VLDL_PL 1.1000694 0.02895794 3.293511286 9.894437e-04 1.0396530
## S_VLDL_CE_. 0.9108808 0.02844924 -3.281043322 1.034239e-03 0.8613931
## IDL_PL 0.9108410 0.02849154 -3.277708700 1.046533e-03 0.8612914
## S_LDL_PL_. 1.0990085 0.02881148 3.276761802 1.050049e-03 1.0389281
## TG.PG 1.0984018 0.02865089 3.275857979 1.053415e-03 1.0385687
## Alb 0.9103058 0.02869120 -3.275385147 1.055180e-03 0.8604031
## L_VLDL_L 1.0991207 0.02887095 3.273549314 1.062059e-03 1.0388933
## L_VLDL_FC 1.0990895 0.02888790 3.270646995 1.073018e-03 1.0388392
## XL_VLDL_FC 1.0989121 0.02893517 3.259724233 1.115206e-03 1.0385989
## IDL_FC_. 0.9103021 0.02890716 -3.251054695 1.149777e-03 0.8598323
## XL_VLDL_C 1.0973633 0.02887978 3.217140937 1.294750e-03 1.0372253
## L_VLDL_PL 1.0962122 0.02885118 3.183954008 1.452781e-03 1.0361749
## S_LDL_TG_. 1.0956579 0.02886737 3.164645701 1.552719e-03 1.0356865
## XL_VLDL_CE 1.0954542 0.02882469 3.162880968 1.562162e-03 1.0355085
## S_LDL_CE 0.9149427 0.02848835 -3.120355139 1.806331e-03 0.8651856
## HDL3_C 0.9151965 0.02844349 -3.115526176 1.836171e-03 0.8655042
## M_VLDL_CE_. 0.9153951 0.02840994 -3.111568765 1.860961e-03 0.8657184
## S_HDL_P 0.9132832 0.02921287 -3.105111427 1.902074e-03 0.8620030
## XS_VLDL_TG_. 1.0930033 0.02865002 3.103986822 1.909318e-03 1.0335164
## XXL_VLDL_C 1.0936224 0.02885753 3.101287675 1.926810e-03 1.0337237
## S_LDL_C 0.9155920 0.02849536 -3.094694664 1.970156e-03 0.8657856
## M_LDL_CE 0.9164239 0.02848580 -3.063849716 2.185086e-03 0.8665939
## L_LDL_PL 0.9166828 0.02851009 -3.051333316 2.278275e-03 0.8667966
## M_VLDL_TG 1.0916222 0.02874543 3.049697630 2.290719e-03 1.0320049
## XS_VLDL_PL 0.9173003 0.02843660 -3.035538038 2.401069e-03 0.8675070
## M_LDL_C 0.9174159 0.02849069 -3.025353270 2.483429e-03 0.8675222
## L_VLDL_C 1.0908030 0.02877373 3.020607120 2.522685e-03 1.0311904
## VLDL_TG 1.0907111 0.02874636 3.020552883 2.523136e-03 1.0311447
## M_LDL_FC_. 1.0903509 0.02870529 3.013366874 2.583664e-03 1.0308780
## LDL_C 0.9188245 0.02848720 -2.971866199 2.959956e-03 0.8688656
## M_HDL_PL 0.9192489 0.02843569 -2.961009938 3.066320e-03 0.8693284
## L_LDL_L 0.9191699 0.02848096 -2.959319205 3.083196e-03 0.8692033
## L_LDL_C 0.9193039 0.02848632 -2.953647687 3.140423e-03 0.8693210
## EstC 0.9196254 0.02850777 -2.939159037 3.291042e-03 0.8695910
## S_HDL_PL_. 1.0871347 0.02855175 2.926107780 3.432320e-03 1.0280949
## M_HDL_L 0.9201515 0.02844513 -2.925523679 3.438770e-03 0.8701722
## L_LDL_P 0.9201680 0.02847779 -2.921539533 3.483061e-03 0.8701536
## XS_VLDL_FC 0.9203660 0.02841169 -2.920765547 3.491725e-03 0.8704458
## M_VLDL_C_. 0.9205900 0.02838855 -2.914572573 3.561760e-03 0.8706766
## M_HDL_C 0.9211114 0.02844412 -2.888972122 3.865033e-03 0.8710919
## M_LDL_L 0.9213741 0.02849431 -2.873875405 4.054689e-03 0.8712593
## M_HDL_P 0.9215134 0.02844432 -2.873611859 4.058073e-03 0.8714601
## IDL_L 0.9215928 0.02845966 -2.869035354 4.117258e-03 0.8715357
## IDL_C 0.9215884 0.02847814 -2.867343548 4.139334e-03 0.8714923
## M_LDL_P 0.9217500 0.02849127 -2.859865611 4.238206e-03 0.8716206
## M_LDL_FC 0.9219557 0.02853901 -2.847265660 4.409655e-03 0.8717065
## S_LDL_FC 0.9220007 0.02855126 -2.844332703 4.450455e-03 0.8717199
## Serum_C 0.9230880 0.02847877 -2.810189296 4.951237e-03 0.8729176
## IDL_P 0.9234278 0.02845548 -2.799554797 5.117313e-03 0.8732804
## L_LDL_CE 0.9234317 0.02848903 -2.796111055 5.172162e-03 0.8732247
## S_LDL_L 0.9233986 0.02850810 -2.795494455 5.182039e-03 0.8731451
## M_VLDL_P 1.0834693 0.02868769 2.794515586 5.197754e-03 1.0243899
## XL_HDL_TG 1.0825009 0.02867858 2.764222513 5.705861e-03 1.0235097
## S_HDL_TG_. 1.0821782 0.02857543 2.763768578 5.713805e-03 1.0233606
## XL_HDL_PL_. 0.9240949 0.02868462 -2.752015350 5.922974e-03 0.8733965
## M_VLDL_L 1.0817179 0.02867558 2.739278788 6.157414e-03 1.0227534
## Glc 1.0827224 0.02909380 2.731804758 6.298846e-03 1.0231564
## S_LDL_P 0.9251740 0.02850602 -2.728315453 6.365870e-03 0.8748288
## L_VLDL_CE 1.0806851 0.02866943 2.706547458 6.798686e-03 1.0217947
## S_HDL_FC_. 1.0800681 0.02849873 2.702718757 6.877491e-03 1.0214820
## XL_HDL_TG_. 1.0804054 0.02870273 2.694388358 7.051795e-03 1.0214954
## M_HDL_CE 0.9265440 0.02843679 -2.682923354 7.298171e-03 0.8762454
## M_VLDL_FC 1.0795855 0.02865595 2.672294880 7.533442e-03 1.0207730
## XXL_VLDL_CE 1.0794092 0.02871062 2.661520551 7.778859e-03 1.0205240
## Serum_TG 1.0785098 0.02865693 2.637416527 8.354018e-03 1.0197572
## S_VLDL_FC_. 0.9284211 0.02843118 -2.612269422 8.994334e-03 0.8780364
## XS_VLDL_FC_. 0.9283477 0.02878914 -2.582533632 9.807780e-03 0.8771442
## HDL_C 0.9299569 0.02838293 -2.558475818 1.051321e-02 0.8795825
## M_VLDL_PL 1.0760255 0.02864305 2.558183433 1.052206e-02 1.0174234
## XS_VLDL_C 0.9301688 0.02840176 -2.548756433 1.081078e-02 0.8797499
## IDL_CE 0.9300999 0.02848432 -2.543969013 1.096008e-02 0.8795385
## L_VLDL_CE_. 0.9308202 0.02853174 -2.512611634 1.198412e-02 0.8801166
## FreeC 0.9314252 0.02846333 -2.495823051 1.256653e-02 0.8808315
## XL_HDL_C_. 1.0731589 0.02860881 2.468000997 1.358699e-02 1.0147580
## L_LDL_PL_. 1.0728844 0.02867164 2.453668452 1.414073e-02 1.0144853
## HDL2_C 0.9331092 0.02837444 -2.439980608 1.468805e-02 0.8825818
## SM 0.9333039 0.02848481 -2.423199035 1.538450e-02 0.8825582
## XL_HDL_CE_. 1.0709893 0.02858719 2.399072869 1.643664e-02 1.0127537
## L_HDL_PL 0.9342998 0.02838523 -2.394129610 1.665986e-02 0.8836830
## S_LDL_FC_. 1.0705925 0.02858944 2.385925228 1.703621e-02 1.0123619
## IDL_PL_. 0.9351702 0.02856895 -2.346141046 1.896893e-02 0.8840805
## L_LDL_C_. 0.9355948 0.02875072 -2.315519366 2.058453e-02 0.8840165
## XS_VLDL_CE 0.9368995 0.02840417 -2.294708255 2.174985e-02 0.8861170
## LA.FA 0.9372747 0.02850066 -2.272890943 2.303275e-02 0.8862465
## S_VLDL_TG 1.0645333 0.02851398 2.193186779 2.829392e-02 1.0067702
## bOHBut 0.9387960 0.02915786 -2.166040563 3.030809e-02 0.8859118
## S_VLDL_PL_. 0.9405078 0.02836914 -2.162044036 3.061478e-02 0.8895775
## XS_VLDL_L 0.9411773 0.02838711 -2.135609343 3.271127e-02 0.8901990
## M_LDL_PL 0.9409561 0.02853999 -2.132405435 3.297353e-02 0.8896902
## IDL_TG_. 1.0627602 0.02859031 2.129023565 3.325231e-02 1.0049854
## ApoA1 0.9422090 0.02837520 -2.097893635 3.591454e-02 0.8911952
## S_LDL_PL 0.9425044 0.02858048 -2.071856744 3.827880e-02 0.8910505
## L_VLDL_PL_. 0.9423357 0.02874543 -2.066197176 3.880987e-02 0.8904535
## L_LDL_FC_. 0.9427978 0.02868464 -2.053485359 4.002553e-02 0.8909779
## M_VLDL_C 1.0602802 0.02855748 2.049663042 4.039732e-02 1.0026674
## M_LDL_TG_. 1.0604638 0.02865889 2.048451639 4.051577e-02 1.0027433
## L_HDL_CE_. 1.0594130 0.02850182 2.024957941 4.287168e-02 1.0018854
## XXL_VLDL_CE_. 0.9443738 0.02926796 -1.955492221 5.052500e-02 0.8912229
## L_LDL_TG 0.9466320 0.02831783 -1.936761827 5.277446e-02 0.8954761
## L_HDL_P 0.9466124 0.02836927 -1.933978485 5.311577e-02 0.8953704
## L_HDL_L 0.9473531 0.02836814 -1.906484608 5.658736e-02 0.8960744
## L_HDL_PL_. 0.9470553 0.02855752 -1.904851696 5.679935e-02 0.8954448
## XS_VLDL_P 0.9478139 0.02838181 -1.888431564 5.896804e-02 0.8964911
## MUFA.FA 1.0545957 0.02843370 1.869524186 6.154992e-02 0.9975042
## M_LDL_TG 0.9491905 0.02833461 -1.840355650 6.571604e-02 0.8978615
## XS_VLDL_C_. 0.9493315 0.02840438 -1.830604839 6.715955e-02 0.8978137
## S_HDL_TG 1.0511069 0.02841369 1.754216457 7.939342e-02 0.9942336
## M_HDL_TG_. 1.0504567 0.02848675 1.727996976 8.398877e-02 0.9935003
## Gln 0.9529277 0.02844953 -1.694800635 9.011325e-02 0.9011932
## L_LDL_TG_. 1.0492689 0.02859667 1.681791310 9.260931e-02 0.9922618
## L_HDL_FC_. 0.9530716 0.02858162 -1.681682382 9.263045e-02 0.9010091
## L_HDL_TG_. 1.0484161 0.02858316 1.654139665 9.809914e-02 0.9914429
## M_HDL_C_. 0.9540493 0.02847099 -1.652207052 9.849235e-02 0.9021467
## S_HDL_FC 0.9541003 0.02851277 -1.647910292 9.937108e-02 0.9020266
## L_HDL_FC 0.9555246 0.02836270 -1.604036082 1.087061e-01 0.9038258
## Crea 0.9559761 0.02854324 -1.577339362 1.147175e-01 0.9037960
## XXL_VLDL_C_. 0.9560533 0.02913716 -1.542414684 1.229729e-01 0.9026315
## L_VLDL_TG_. 1.0446789 0.02856437 1.530213536 1.259639e-01 0.9879342
## L_LDL_CE_. 0.9571922 0.02864796 -1.527196610 1.267121e-01 0.9047222
## Ala 1.0442329 0.02837586 1.525328948 1.271771e-01 0.9878002
## TotCho 0.9578073 0.02843077 -1.516269475 1.294512e-01 0.9058185
## FAw6 0.9582934 0.02849863 -1.494855241 1.349522e-01 0.9062039
## XL_VLDL_TG_. 1.0439747 0.02889865 1.489180396 1.364399e-01 0.9866008
## XXL_VLDL_FC_. 1.0449086 0.02952300 1.487973978 1.367578e-01 0.9865440
## L_HDL_C 0.9588429 0.02836211 -1.481837886 1.383834e-01 0.9069681
## IDL_C_. 0.9588613 0.02857241 -1.470258319 1.414918e-01 0.9065224
## L_HDL_CE 0.9599664 0.02836187 -1.440559525 1.497092e-01 0.9080320
## XL_VLDL_PL_. 0.9597829 0.02902140 -1.414410915 1.572413e-01 0.9064737
## LDL_TG 0.9611027 0.02831996 -1.400919671 1.612381e-01 0.9091820
## IDL_CE_. 1.0401081 0.02867225 1.371522877 1.702120e-01 0.9833052
## S_VLDL_CE 0.9619966 0.02838250 -1.365078369 1.722284e-01 0.9099162
## M_VLDL_CE 1.0393904 0.02848347 1.356380781 1.749780e-01 0.9830197
## PUFA 0.9629685 0.02846514 -1.325642090 1.849583e-01 0.9106896
## HDL_TG 1.0383413 0.02843992 1.322947883 1.858527e-01 0.9821127
## S_VLDL_P 1.0378454 0.02844094 1.306102597 1.915177e-01 0.9816274
## SFA 1.0376046 0.02857379 1.291911179 1.963879e-01 0.9811597
## M_VLDL_FC_. 1.0368144 0.02829267 1.277821284 2.013124e-01 0.9808748
## IDL_TG 0.9647436 0.02830110 -1.268252228 2.047079e-01 0.9126536
## XXL_VLDL_TG_. 1.0371113 0.02910546 1.251973463 2.105795e-01 0.9796654
## DHA.FA 0.9651458 0.02845158 -1.246892321 2.124370e-01 0.9127529
## L_VLDL_C_. 0.9652610 0.02852262 -1.239602961 2.151223e-01 0.9126120
## L_VLDL_FC_. 1.0357058 0.02844795 1.233237561 2.174871e-01 0.9795076
## PC 0.9660234 0.02843629 -1.215601502 2.241368e-01 0.9136150
## LDL_D 0.9666511 0.02832283 -1.197537990 2.310969e-01 0.9144072
## TotPG 0.9669728 0.02843231 -1.181224357 2.375136e-01 0.9145220
## MUFA 1.0333747 0.02853851 1.150371488 2.499909e-01 0.9772317
## Gly 0.9681000 0.02833562 -1.144138114 2.525664e-01 0.9157279
## S_VLDL_L 1.0319009 0.02842897 1.104599479 2.693332e-01 0.9760199
## VLDL_C 1.0295206 0.02847161 1.021835301 3.068589e-01 0.9736874
## M_HDL_PL_. 1.0294689 0.02854693 1.017378021 3.089736e-01 0.9735905
## Lac 1.0292487 0.02895813 0.995544838 3.194713e-01 0.9727392
## LA 0.9721281 0.02849423 -0.992049792 3.211732e-01 0.9193038
## XL_HDL_PL 0.9738271 0.02831610 -0.936623737 3.489521e-01 0.9212382
## XL_VLDL_C_. 0.9745527 0.02881191 -0.894652882 3.709727e-01 0.9208596
## HDL_D 0.9758850 0.02834517 -0.861189085 3.891339e-01 0.9231348
## FAw3.FA 0.9763658 0.02842725 -0.841374984 4.001379e-01 0.9234309
## XS_VLDL_CE_. 0.9764764 0.02832945 -0.840279412 4.007517e-01 0.9236817
## XL_VLDL_FC_. 0.9762122 0.02886484 -0.834070417 4.042413e-01 0.9223664
## XL_HDL_FC_. 1.0238403 0.02836498 0.830620035 4.061883e-01 0.9684548
## XXL_VLDL_PL_. 1.0247666 0.02954899 0.827941897 4.077034e-01 0.9677235
## S_VLDL_PL 1.0230346 0.02841078 0.801572391 4.228004e-01 0.9676597
## DHA 0.9786646 0.02832457 -0.761400077 4.464181e-01 0.9257906
## S_HDL_PL 0.9797455 0.02835427 -0.721671882 4.704962e-01 0.9266749
## ApoB.ApoA1 1.0204461 0.02847442 0.710809518 4.772023e-01 0.9650701
## His 1.0191149 0.02851252 0.664075473 5.066420e-01 0.9637699
## L_HDL_TG 0.9820382 0.02836104 -0.639084887 5.227677e-01 0.9289290
## S_VLDL_C 0.9821396 0.02838290 -0.634954494 5.254581e-01 0.9289858
## S_VLDL_FC 1.0181715 0.02839501 0.634209096 5.259444e-01 0.9630842
## Remnant_C 0.9824068 0.02846144 -0.623643673 5.328616e-01 0.9290977
## L_HDL_C_. 1.0176107 0.02847873 0.612999286 5.398768e-01 0.9623381
## XS_VLDL_TG 1.0173893 0.02835626 0.607972617 5.432056e-01 0.9624212
## Phe 1.0173121 0.02849000 0.602453915 5.468720e-01 0.9620961
## TotFA 1.0155099 0.02851678 0.539712181 5.893955e-01 0.9603408
## XL_VLDL_CE_. 0.9848801 0.02879929 -0.529019635 5.967918e-01 0.9307406
## M_HDL_CE_. 0.9862227 0.02836844 -0.489033320 6.248181e-01 0.9327920
## XL_HDL_CE 1.0136140 0.02830550 0.477722342 6.328478e-01 0.9589323
## Cit 0.9866570 0.02866766 -0.468569825 6.393772e-01 0.9327370
## Ace 1.0132993 0.02850742 0.463446512 6.430443e-01 0.9585656
## AcAce 0.9884754 0.02834003 -0.409017656 6.825267e-01 0.9350169
## Pyr 1.0102013 0.02859032 0.355002132 7.225880e-01 0.9553072
## XL_HDL_C 1.0098745 0.02830233 0.347183603 7.284534e-01 0.9553992
## ApoB 0.9906459 0.02849486 -0.329816454 7.415387e-01 0.9368352
## Gp 1.0091119 0.02840483 0.319332892 7.494741e-01 0.9544928
## FAw3 0.9935777 0.02835618 -0.227216867 8.202551e-01 0.9398752
## XL_HDL_P 0.9938019 0.02830029 -0.219692279 8.261108e-01 0.9401859
## XL_HDL_L 0.9939699 0.02829927 -0.213729650 8.307579e-01 0.9403466
## S_LDL_TG 1.0050338 0.02837415 0.176963149 8.595373e-01 0.9506800
## M_HDL_TG 1.0049466 0.02838560 0.173836536 8.619939e-01 0.9505751
## XL_HDL_FC 1.0002044 0.02829500 0.007222495 9.942373e-01 0.9462585
## 97.5 % sig
## Glol 0.7595052 yes
## M_VLDL_PL_. 0.9242666 yes
## S_HDL_C 0.9240081 yes
## S_HDL_CE 0.9279242 yes
## Tyr 1.2016918 yes
## Ile 1.2011138 yes
## SFA.FA 1.1929761 yes
## Leu 1.1914374 yes
## M_HDL_FC_. 0.9428876 yes
## XS_VLDL_PL_. 0.9488671 yes
## XXL_VLDL_TG 1.1762658 yes
## M_LDL_PL_. 1.1761039 yes
## VLDL_D 1.1718313 yes
## S_VLDL_TG_. 1.1695458 yes
## M_HDL_FC 0.9562880 yes
## XL_VLDL_TG 1.1729668 yes
## XXL_VLDL_L 1.1727603 yes
## IDL_FC 0.9569798 yes
## XXL_VLDL_FC 1.1720599 yes
## XXL_VLDL_PL 1.1715715 yes
## XL_VLDL_P 1.1703146 yes
## FAw6.FA 0.9582680 yes
## S_LDL_C_. 0.9577877 yes
## XL_VLDL_L 1.1696816 yes
## M_LDL_CE_. 0.9582322 yes
## M_VLDL_TG_. 1.1653008 yes
## S_LDL_CE_. 0.9585960 yes
## L_LDL_FC 0.9599033 yes
## L_VLDL_TG 1.1675530 yes
## PUFA.FA 0.9603454 yes
## Val 1.1646653 yes
## M_LDL_C_. 0.9598650 yes
## S_VLDL_C_. 0.9609184 yes
## S_HDL_C_. 0.9619407 yes
## S_HDL_CE_. 0.9620318 yes
## S_HDL_L 0.9609541 yes
## UnSat 0.9623648 yes
## L_VLDL_P 1.1643087 yes
## XL_VLDL_PL 1.1646879 yes
## S_VLDL_CE_. 0.9630403 yes
## IDL_PL 0.9630872 yes
## S_LDL_PL_. 1.1632110 yes
## TG.PG 1.1620539 yes
## Alb 0.9628548 yes
## L_VLDL_L 1.1634326 yes
## L_VLDL_FC 1.1634514 yes
## XL_VLDL_FC 1.1634033 yes
## IDL_FC_. 0.9630643 yes
## XL_VLDL_C 1.1616091 yes
## L_VLDL_PL 1.1603066 no
## S_LDL_TG_. 1.1598472 no
## XL_VLDL_CE 1.1594407 no
## S_LDL_CE 0.9674275 no
## HDL3_C 0.9676132 no
## M_VLDL_CE_. 0.9677368 no
## S_HDL_P 0.9666384 no
## XS_VLDL_TG_. 1.1564119 no
## XXL_VLDL_C 1.1575953 no
## S_LDL_C 0.9681256 no
## M_LDL_CE 0.9689923 no
## L_LDL_PL 0.9693120 no
## M_VLDL_TG 1.1551487 no
## XS_VLDL_PL 0.9698285 no
## M_LDL_C 0.9700494 no
## L_VLDL_C 1.1543702 no
## VLDL_TG 1.1541913 no
## M_LDL_FC_. 1.1537075 no
## LDL_C 0.9715375 no
## M_HDL_PL 0.9718678 no
## L_LDL_L 0.9718918 no
## L_LDL_C 0.9720436 no
## EstC 0.9724267 no
## S_HDL_PL_. 1.1498892 no
## M_HDL_L 0.9728452 no
## L_LDL_P 0.9729424 no
## XS_VLDL_FC 0.9730206 no
## M_VLDL_C_. 0.9731959 no
## M_HDL_C 0.9738663 no
## M_LDL_L 0.9742430 no
## M_HDL_P 0.9742829 no
## IDL_L 0.9744182 no
## IDL_C 0.9744411 no
## M_LDL_P 0.9746355 no
## M_LDL_FC 0.9749192 no
## S_LDL_FC 0.9749826 no
## Serum_C 0.9760359 no
## IDL_P 0.9763528 no
## L_LDL_CE 0.9764186 no
## S_LDL_L 0.9764058 no
## M_VLDL_P 1.1463628 no
## XL_HDL_TG 1.1453425 no
## S_HDL_TG_. 1.1446997 no
## XL_HDL_PL_. 0.9773820 no
## M_VLDL_L 1.1444766 no
## Glc 1.1468943 no
## S_LDL_P 0.9782808 no
## L_VLDL_CE 1.1433785 no
## S_HDL_FC_. 1.1422490 no
## XL_HDL_TG_. 1.1432028 no
## M_HDL_CE 0.9796000 no
## M_VLDL_FC 1.1421724 no
## XXL_VLDL_CE 1.1421469 no
## Serum_TG 1.1410416 no
## S_VLDL_FC_. 0.9815828 no
## XS_VLDL_FC_. 0.9819995 no
## HDL_C 0.9831220 no
## M_VLDL_PL 1.1383658 no
## XS_VLDL_C 0.9833807 no
## IDL_CE 0.9834615 no
## L_VLDL_CE_. 0.9843009 no
## FreeC 0.9848272 no
## XL_HDL_C_. 1.1352285 no
## L_LDL_PL_. 1.1352379 no
## HDL2_C 0.9864418 no
## SM 0.9868421 no
## XL_HDL_CE_. 1.1328918 no
## L_HDL_PL 0.9877173 no
## S_LDL_FC_. 1.1324585 no
## IDL_PL_. 0.9888921 no
## L_LDL_C_. 0.9895637 no
## XS_VLDL_CE 0.9905068 no
## LA.FA 0.9910346 no
## S_VLDL_TG 1.1258688 no
## bOHBut 0.9934837 no
## S_VLDL_PL_. 0.9942559 no
## XS_VLDL_L 0.9950045 no
## M_LDL_PL 0.9950370 no
## IDL_TG_. 1.1242268 no
## ApoA1 0.9960707 no
## S_LDL_PL 0.9967257 no
## L_VLDL_PL_. 0.9967447 no
## L_LDL_FC_. 0.9970922 no
## M_VLDL_C 1.1214745 no
## M_LDL_TG_. 1.1220472 no
## L_HDL_CE_. 1.1203573 no
## XXL_VLDL_CE_. 0.9998496 no
## L_LDL_TG 1.0006397 no
## L_HDL_P 1.0007200 no
## L_HDL_L 1.0015024 no
## L_HDL_PL_. 1.0015437 no
## XS_VLDL_P 1.0020171 no
## MUFA.FA 1.1151541 no
## M_LDL_TG 1.0033716 no
## XS_VLDL_C_. 1.0035942 no
## S_HDL_TG 1.1114079 no
## M_HDL_TG_. 1.1109132 no
## Gln 1.0075397 no
## L_LDL_TG_. 1.1100580 no
## L_HDL_FC_. 1.0078764 no
## L_HDL_TG_. 1.1090642 no
## M_HDL_C_. 1.0087057 no
## S_HDL_FC 1.0087769 no
## L_HDL_FC 1.0101437 no
## Crea 1.0109093 no
## XXL_VLDL_C_. 1.0121138 no
## L_VLDL_TG_. 1.1050595 no
## L_LDL_CE_. 1.0123197 no
## Ala 1.1040553 no
## TotCho 1.0126471 no
## FAw6 1.0133337 no
## XL_VLDL_TG_. 1.1050472 no
## XXL_VLDL_FC_. 1.1078404 no
## L_HDL_C 1.0136545 no
## IDL_C_. 1.0140011 no
## L_HDL_CE 1.0148430 no
## XL_VLDL_PL_. 1.0157786 no
## LDL_TG 1.0159619 no
## IDL_CE_. 1.1003120 no
## S_VLDL_CE 1.0170237 no
## M_VLDL_CE 1.0991756 no
## PUFA 1.0182166 no
## HDL_TG 1.0979754 no
## S_VLDL_P 1.0974328 no
## SFA 1.0974873 no
## M_VLDL_FC_. 1.0960062 no
## IDL_TG 1.0197711 no
## XXL_VLDL_TG_. 1.0983671 no
## DHA.FA 1.0205007 no
## L_VLDL_C_. 1.0206411 no
## L_VLDL_FC_. 1.0951253 no
## PC 1.0213756 no
## LDL_D 1.0218146 no
## TotPG 1.0223736 no
## MUFA 1.0929471 no
## Gly 1.0233893 no
## S_VLDL_L 1.0911118 no
## VLDL_C 1.0886855 no
## M_HDL_PL_. 1.0889824 no
## Lac 1.0899246 no
## LA 1.0279651 no
## XL_HDL_PL 1.0294217 no
## XL_VLDL_C_. 1.0311647 no
## HDL_D 1.0316488 no
## FAw3.FA 1.0323403 no
## XS_VLDL_CE_. 1.0321999 no
## XL_VLDL_FC_. 1.0329316 no
## XL_HDL_FC_. 1.0824141 no
## XXL_VLDL_PL_. 1.0875150 no
## S_VLDL_PL 1.0816894 no
## DHA 1.0345784 no
## S_HDL_PL 1.0356912 no
## ApoB.ApoA1 1.0790545 no
## His 1.0778242 no
## L_HDL_TG 1.0382013 no
## S_VLDL_C 1.0383414 no
## S_VLDL_FC 1.0765078 no
## Remnant_C 1.0387828 no
## L_HDL_C_. 1.0760367 no
## XS_VLDL_TG 1.0756067 no
## Phe 1.0758153 no
## TotFA 1.0739551 no
## XL_VLDL_CE_. 1.0421950 no
## M_HDL_CE_. 1.0425629 no
## XL_HDL_CE 1.0714934 no
## Cit 1.0436982 no
## Ace 1.0729927 no
## AcAce 1.0450823 no
## Pyr 1.0702785 no
## XL_HDL_C 1.0675335 no
## ApoB 1.0475714 no
## Gp 1.0669487 no
## FAw3 1.0504256 no
## XL_HDL_P 1.0505310 no
## XL_HDL_L 1.0507061 no
## S_LDL_TG 1.0625591 no
## M_HDL_TG 1.0624843 no
## XL_HDL_FC 1.0572925 no# Results after PCA correction
p.Funk <-function(Dat){
p.Dat <-subset(Dat,Dat$'Pr(>|z|)'<0.0013)
return(p.Dat)
}
TEST <-p.Funk(copy_result)
TEST$sig <- "yes"
p.Funk2 <-function(Dat){
p.Dat <-subset(Dat,Dat$'Pr(>|z|)'>=0.0013)
return(p.Dat)
}
TEST2 <-p.Funk2(copy_result)
TEST2$sig <- "no"
178+49## [1] 227Analysis by stage (odds of localized advanced)
# Sorted list of stage results
copy_result2 = copy_result2[order(copy_result2$'Pr(>|z|)'),]
# head(copy_result2)
copy_result2$sig <- ifelse(copy_result2$'Pr(>|z|)'<0.0013,"yes","no")
# List of PCa results sorted by p-value
copy_result2## Estimate Std. Error z value Pr(>|z|) 2.5 %
## S_HDL_PL_. 1.2720512 0.06839641 3.51817797 0.0004345208 1.1110754
## M_LDL_C_. 0.8116783 0.06360146 -3.28060442 0.0010358492 0.7183537
## S_HDL_CE_. 0.8017128 0.06759059 -3.26975714 0.0010763986 0.7032337
## M_LDL_PL_. 1.2304860 0.06355657 3.26337918 0.0011009212 1.0826594
## S_LDL_PL_. 1.2312158 0.06374104 3.26323782 0.0011014705 1.0834819
## S_HDL_C_. 0.8032518 0.06753112 -3.24423758 0.0011776547 0.7047022
## S_LDL_C_. 0.8149478 0.06333128 -3.23112308 0.0012330483 0.7215504
## S_LDL_CE_. 0.8141056 0.06370565 -3.22836695 0.0012449916 0.7201967
## M_LDL_CE_. 0.8162726 0.06423405 -3.16042466 0.0015753934 0.7215156
## PUFA.FA 0.8146370 0.06815294 -3.00812622 0.0026286394 0.7134240
## XS_VLDL_FC_. 0.8216553 0.06704624 -2.92983260 0.0033914465 0.7219893
## S_HDL_FC_. 1.2262456 0.07039304 2.89740449 0.0037626428 1.0675066
## DHA.FA 0.8028080 0.07871376 -2.79035912 0.0052649608 0.6857874
## XS_VLDL_PL_. 0.8288511 0.06738787 -2.78558631 0.0053431014 0.7281503
## L_VLDL_CE_. 0.8200058 0.07264342 -2.73175362 0.0062998233 0.7104430
## UnSat 0.8268142 0.07027164 -2.70628689 0.0068040237 0.7204406
## S_HDL_CE 0.8320790 0.06839935 -2.68756796 0.0071974455 0.7287497
## SFA.FA 1.2041275 0.06916880 2.68553522 0.0072413743 1.0508241
## FAw3.FA 0.8125778 0.07811322 -2.65695950 0.0078848915 0.6947628
## S_LDL_TG_. 1.1847070 0.06533134 2.59439842 0.0094756611 1.0386050
## M_LDL_TG_. 1.1858638 0.06590555 2.58660218 0.0096927428 1.0387497
## LDL_D 1.1905098 0.06948072 2.50978384 0.0120805085 1.0383424
## S_HDL_PL 1.1903855 0.07063744 2.46720736 0.0136171478 1.0358283
## FAw6.FA 0.8488473 0.06863173 -2.38775860 0.0169514723 0.7428381
## XL_VLDL_CE_. 0.8178215 0.08594273 -2.34006006 0.0192806389 0.6878369
## Leu 1.1825883 0.07175869 2.33707636 0.0194352141 1.0256460
## Ile 1.1784486 0.07059652 2.32587765 0.0200250784 1.0244425
## S_LDL_FC_. 1.1713778 0.06818982 2.31971022 0.0203565586 1.0227831
## S_HDL_C 0.8540557 0.06853028 -2.30203072 0.0213334398 0.7479322
## IDL_FC_. 0.8602245 0.06582608 -2.28726842 0.0221801604 0.7584225
## S_LDL_CE 0.8501120 0.07104870 -2.28557612 0.0222790684 0.7391046
## M_LDL_FC_. 1.1672181 0.06771416 2.28346951 0.0224027271 1.0194354
## M_HDL_PL 1.1652887 0.06753878 2.26490359 0.0235185966 1.0192946
## Alb 1.1747404 0.07114983 2.26349354 0.0236052823 1.0227088
## XXL_VLDL_CE_. 0.8111310 0.09272563 -2.25747426 0.0239784560 0.6703212
## M_VLDL_FC_. 1.1962509 0.07946723 2.25492179 0.0241382381 1.0287365
## M_HDL_P 1.1647030 0.06785779 2.24684779 0.0246497566 1.0182373
## L_LDL_C_. 0.8738574 0.06044349 -2.23081223 0.0256935692 0.7784143
## S_VLDL_CE_. 0.8579857 0.06929998 -2.21021399 0.0270903146 0.7491901
## M_HDL_TG 1.1666090 0.07002652 2.20061316 0.0277634211 1.0157528
## MUFA.FA 1.1614373 0.06822128 2.19371859 0.0282556468 1.0144777
## HDL_TG 1.1598041 0.06815592 2.17517542 0.0296169731 1.0128467
## S_LDL_C 0.8577587 0.07081715 -2.16660062 0.0302653200 0.7461506
## Val 1.1662990 0.07111485 2.16319730 0.0305260075 1.0134759
## M_LDL_CE 0.8590457 0.07107230 -2.13772614 0.0325389769 0.7467649
## M_HDL_L 1.1562231 0.06798247 2.13523771 0.0327415981 1.0105975
## VLDL_D 1.1652908 0.07164502 2.13511962 0.0327512408 1.0123772
## XXL_VLDL_FC 1.1554785 0.06857994 2.10724267 0.0350965496 1.0062687
## S_VLDL_C_. 0.8643646 0.06967896 -2.09188926 0.0364484229 0.7541333
## L_VLDL_FC_. 1.1856885 0.08182025 2.08168002 0.0373717069 1.0163898
## M_LDL_C 0.8643900 0.07081855 -2.05781196 0.0396081880 0.7518471
## XXL_VLDL_PL 1.1522962 0.06891284 2.05704267 0.0396821220 1.0027819
## XXL_VLDL_TG 1.1522365 0.06900223 2.05362658 0.0400118477 1.0025165
## XL_VLDL_TG 1.1495904 0.06889090 2.02357176 0.0430142331 1.0006862
## XXL_VLDL_L 1.1489791 0.06901324 2.01227827 0.0441906113 0.9997204
## XL_HDL_TG 1.1466945 0.06816987 2.00797621 0.0446458200 1.0006562
## IDL_PL_. 0.8703295 0.06917513 -2.00770760 0.0446743727 0.7614127
## L_LDL_TG_. 1.1344269 0.06287888 2.00588157 0.0448688851 0.9984313
## LA.FA 0.8735707 0.06764711 -1.99810816 0.0457049351 0.7662539
## XS_VLDL_TG_. 1.1443588 0.06796275 1.98409328 0.0472454417 0.9990652
## XL_VLDL_P 1.1448451 0.06900324 1.96033273 0.0499569125 0.9963399
## XXL_VLDL_C_. 0.8409262 0.08852319 -1.95712969 0.0503322221 0.7007926
## XL_VLDL_L 1.1440815 0.06900775 1.95053693 0.0511121557 0.9956715
## L_LDL_PL_. 1.1268185 0.06187527 1.92965895 0.0536491095 0.9938335
## XL_VLDL_PL 1.1414027 0.06909910 1.91403254 0.0556159977 0.9931064
## AcAce 1.1201582 0.06036151 1.87983827 0.0601301228 0.9886802
## XL_VLDL_FC 1.1385702 0.06905741 1.87920774 0.0602161330 0.9907407
## L_LDL_FC_. 0.8816092 0.06718053 -1.87563955 0.0607047915 0.7753204
## L_VLDL_FC 1.1364063 0.06916658 1.84873819 0.0644956256 0.9888952
## L_VLDL_TG 1.1365218 0.06928494 1.84704672 0.0647403697 0.9888191
## XL_HDL_TG_. 1.1328438 0.06763343 1.84422207 0.0651507827 0.9887874
## S_VLDL_TG_. 1.1385554 0.07042828 1.84244586 0.0654099595 0.9917475
## Tyr 1.1363312 0.06961366 1.83591592 0.0663700927 0.9895471
## LDL_C 0.8803561 0.07082213 -1.79927985 0.0719744231 0.7656106
## S_LDL_L 0.8812356 0.07043382 -1.79502269 0.0726500842 0.7672279
## M_LDL_L 0.8815265 0.07049069 -1.78889190 0.0736322261 0.7672784
## L_VLDL_P 1.1318930 0.06938140 1.78565856 0.0741545582 0.9846488
## L_VLDL_L 1.1314659 0.06939402 1.77989419 0.0750932779 0.9842653
## XS_VLDL_FC 0.8812982 0.07154850 -1.76606322 0.0773852433 0.7650886
## L_VLDL_PL 1.1299600 0.06941434 1.76018734 0.0783760480 0.9829080
## M_LDL_P 0.8836236 0.07051724 -1.75452332 0.0793408775 0.7690471
## M_HDL_CE 1.1278402 0.06880627 1.74845239 0.0803857223 0.9844653
## XXL_VLDL_C 1.1285512 0.06917694 1.74819373 0.0804304877 0.9819341
## S_LDL_P 0.8846591 0.07044018 -1.73981605 0.0818913240 0.7701841
## S_HDL_FC 1.1329088 0.07205126 1.73194012 0.0832842241 0.9840540
## L_HDL_TG 1.1244281 0.06774191 1.73119600 0.0834168128 0.9825717
## XL_VLDL_C 1.1268110 0.06924450 1.72420226 0.0846713368 0.9802809
## M_HDL_C 1.1242211 0.06881333 1.70156671 0.0888366233 0.9812916
## L_LDL_FC 0.8889475 0.07077484 -1.66326119 0.0962601633 0.7733473
## Gln 1.1209824 0.06889462 1.65768282 0.0973815023 0.9793112
## IDL_FC 0.8909620 0.07072537 -1.63241997 0.1025910440 0.7753041
## M_LDL_FC 0.8932690 0.06927271 -1.62932123 0.1032450331 0.7799437
## M_VLDL_PL_. 0.8907248 0.07148570 -1.61878157 0.1054942682 0.7724415
## L_VLDL_C 1.1188814 0.06952458 1.61567940 0.1061636479 0.9732427
## S_LDL_FC 0.8944585 0.06944039 -1.60622273 0.1082249801 0.7808043
## DHA 0.8862797 0.07616230 -1.58507085 0.1129502368 0.7601660
## L_LDL_CE_. 0.9050774 0.06295685 -1.58417696 0.1131534553 0.8026205
## XL_VLDL_CE 1.1157605 0.06938821 1.57860019 0.1144277905 0.9705375
## XL_HDL_FC_. 1.1210777 0.07292415 1.56725093 0.1170560495 0.9743582
## XXL_VLDL_PL_. 1.1494481 0.08915834 1.56218554 0.1182442854 0.9693192
## XS_VLDL_PL 0.8942251 0.07160164 -1.56138482 0.1184329813 0.7761901
## TG.PG 1.1160075 0.07113968 1.54284620 0.1228680960 0.9687251
## XXL_VLDL_TG_. 1.1369370 0.08341774 1.53849585 0.1239274215 0.9729371
## VLDL_TG 1.1122624 0.06998668 1.52023382 0.1284522193 0.9668314
## L_LDL_C 0.9011020 0.07074827 -1.47193510 0.1410384036 0.7837293
## MUFA 1.1072183 0.06921022 1.47161516 0.1411248307 0.9644417
## Serum_TG 1.1074997 0.06981237 1.46256272 0.1435870697 0.9631698
## M_HDL_FC 1.1063881 0.06922645 1.46043532 0.1441704729 0.9650980
## XL_VLDL_PL_. 1.1244663 0.08041881 1.45871965 0.1446422850 0.9678007
## M_VLDL_TG 1.1073079 0.07019589 1.45210382 0.1464727389 0.9621813
## XL_VLDL_FC_. 1.1192741 0.07819333 1.44104818 0.1495710716 0.9654303
## Cit 1.1049243 0.06980373 1.42939073 0.1528919612 0.9628115
## SFA 1.1043575 0.06970458 1.42406333 0.1544281399 0.9612881
## L_LDL_CE 0.9048063 0.07070283 -1.41485680 0.1571104859 0.7869695
## Glc 1.1020437 0.06976558 1.39275469 0.1636939849 0.9548649
## XXL_VLDL_CE 1.1014224 0.06952455 1.38947168 0.1646893653 0.9579601
## M_VLDL_CE_. 0.9064855 0.07088393 -1.38508532 0.1660263789 0.7877946
## IDL_CE_. 1.1077938 0.07393218 1.38465314 0.1661585530 0.9585693
## IDL_PL 0.9067948 0.07075669 -1.38275340 0.1667404930 0.7888434
## M_VLDL_FC 1.1009337 0.07004406 1.37283133 0.1698047876 0.9571066
## L_LDL_L 0.9079338 0.07083676 -1.36347083 0.1727341704 0.7894631
## L_VLDL_CE 1.0980649 0.06977882 1.34065658 0.1800319795 0.9549284
## M_VLDL_P 1.0985482 0.07029863 1.33700332 0.1812215544 0.9545185
## XL_VLDL_C_. 0.9038024 0.07661884 -1.32010029 0.1868015359 0.7772285
## M_VLDL_L 1.0968504 0.07029257 1.31511455 0.1884714089 0.9530804
## L_LDL_P 0.9113317 0.07085301 -1.31043640 0.1900482454 0.7923566
## M_VLDL_PL 1.0924738 0.07035659 1.25709088 0.2087207283 0.9492281
## IDL_TG_. 1.0886122 0.06838423 1.24156866 0.2143957491 0.9489664
## L_LDL_PL 0.9187329 0.07090134 -1.19546189 0.2319066180 0.7987421
## FAw3 0.9161623 0.07371959 -1.18776828 0.2349247143 0.7902585
## Glol 1.2044942 0.15940836 1.16718912 0.2431340030 0.8799034
## XXL_VLDL_FC_. 1.0807181 0.06999452 1.10902526 0.2674192866 0.9387274
## M_VLDL_TG_. 1.0798041 0.06993584 1.09785854 0.2722662629 0.9426745
## S_VLDL_CE 0.9259310 0.07044185 -1.09246944 0.2746268171 0.8054124
## IDL_C 0.9263745 0.07035228 -1.08705310 0.2770133413 0.8064291
## XS_VLDL_C 0.9267132 0.07051251 -1.07939944 0.2804097005 0.8061818
## His 1.0807132 0.07231380 1.07339345 0.2830946231 0.9368966
## IDL_L 0.9292416 0.07038028 -1.04271445 0.2970805623 0.8086960
## L_HDL_CE 1.0732816 0.06943647 1.01849767 0.3084415079 0.9346884
## M_VLDL_C 1.0737109 0.07018557 1.01332435 0.3109052593 0.9334491
## ApoA1 1.0724755 0.06948899 1.00691588 0.3139751982 0.9347682
## L_HDL_P 1.0721181 0.06966483 0.99958965 0.3175091349 0.9334517
## Gp 1.0725926 0.07025757 0.99745455 0.3185439257 0.9330612
## L_HDL_FC_. 0.9312600 0.07225846 -0.98558361 0.3243374821 0.8104626
## L_HDL_L 1.0697383 0.06970825 0.96708804 0.3335000243 0.9312865
## TotFA 1.0699170 0.07020484 0.96262687 0.3357348097 0.9306888
## S_VLDL_TG 1.0698755 0.07029427 0.96085078 0.3366272008 0.9302079
## IDL_P 0.9348380 0.07033693 -0.95799005 0.3380677772 0.8135934
## XS_VLDL_L 0.9343895 0.07086731 -0.95759157 0.3382687527 0.8119998
## XS_VLDL_C_. 0.9358488 0.06935474 -0.95597466 0.3390850373 0.8183687
## L_HDL_CE_. 1.0691986 0.07285607 0.91837733 0.3584213562 0.9288590
## L_HDL_C 1.0658853 0.06968528 0.91562636 0.3598629025 0.9277941
## M_VLDL_C_. 0.9384469 0.06964845 -0.91213781 0.3616961756 0.8178686
## M_LDL_PL 0.9388115 0.06945128 -0.90913408 0.3632793547 0.8193108
## L_HDL_PL 1.0655480 0.07000150 0.90696941 0.3644229729 0.9274392
## S_HDL_TG 1.0648806 0.07078068 0.88813349 0.3744689494 0.9254884
## Serum_C 0.9395019 0.07029368 -0.88778116 0.3746584806 0.8178658
## XL_HDL_FC 1.0602300 0.06968914 0.83923963 0.4013348552 0.9231209
## IDL_CE 0.9429775 0.07016719 -0.83675604 0.4027297145 0.8211456
## M_HDL_TG_. 1.0599202 0.07022225 0.82870630 0.4072706177 0.9213212
## XS_VLDL_P 0.9438553 0.07078675 -0.81628830 0.4143352638 0.8203181
## L_VLDL_C_. 0.9469697 0.06862596 -0.79398731 0.4272028213 0.8303904
## S_LDL_PL 0.9464532 0.06953942 -0.79140413 0.4287081991 0.8263706
## PC 1.0562893 0.07025405 0.77948619 0.4356933697 0.9198186
## XL_HDL_PL_. 0.9454098 0.07251650 -0.77412388 0.4388575367 0.8224859
## EstC 0.9476839 0.07042788 -0.76296892 0.4454819330 0.8248028
## HDL3_C 0.9489776 0.07060789 -0.74170238 0.4582676784 0.8257922
## S_HDL_TG_. 1.0534507 0.07078881 0.73558446 0.4619836249 0.9147691
## XS_VLDL_CE 0.9508993 0.07007511 -0.71847318 0.4724655762 0.8280600
## Lac 1.0481189 0.06567822 0.71556434 0.4742604006 0.9133350
## FreeC 0.9524669 0.07068855 -0.68893627 0.4908633727 0.8284385
## HDL2_C 1.0483644 0.07010824 0.67368971 0.5005086053 0.9123884
## IDL_C_. 0.9556629 0.06938257 -0.65362366 0.5133542966 0.8364077
## TotPG 1.0470816 0.07067707 0.65094421 0.5150824999 0.9110198
## L_HDL_PL_. 0.9554434 0.07154242 -0.63710139 0.5240588004 0.8292921
## M_VLDL_CE 1.0455467 0.07009088 0.63545931 0.5251288984 0.9092974
## S_VLDL_C 0.9572521 0.07031750 -0.62130318 0.5344001615 0.8327333
## Phe 1.0446412 0.07168888 0.60920875 0.5423860834 0.9062475
## M_HDL_FC_. 0.9586033 0.06986605 -0.60512815 0.5450938525 0.8401527
## L_HDL_FC 1.0427330 0.07047970 0.59371927 0.5526998951 0.9062650
## L_HDL_TG_. 1.0440903 0.07285629 0.59220713 0.5537118968 0.9020228
## S_HDL_P 1.0428197 0.07272326 0.57654558 0.5642464678 0.9069641
## Pyr 0.9565933 0.07880856 -0.56309749 0.5733685006 0.7992380
## HDL_C 1.0401311 0.07033803 0.55939552 0.5758918191 0.9048850
## ApoB.ApoA1 0.9611606 0.07096771 -0.55819387 0.5767120088 0.8357539
## XL_HDL_P 1.0371618 0.07007961 0.52066474 0.6026003387 0.9021118
## XL_HDL_L 1.0367783 0.07009828 0.51524934 0.6063787929 0.9017756
## L_VLDL_TG_. 1.0360135 0.06909432 0.51205627 0.6086116287 0.9015137
## S_VLDL_P 1.0352540 0.07044605 0.49182001 0.6228465924 0.9001230
## M_HDL_C_. 0.9659219 0.07091320 -0.48894019 0.6248840425 0.8424642
## S_VLDL_PL 1.0348087 0.07027589 0.48688985 0.6263363901 0.9000169
## PUFA 0.9677128 0.07036624 -0.46641594 0.6409178035 0.8420772
## S_VLDL_FC_. 0.9671031 0.07217352 -0.46346852 0.6430285774 0.8385226
## VLDL_C 1.0329856 0.07053984 0.46006939 0.6454664134 0.8979688
## XL_HDL_C 1.0326520 0.07040162 0.45638551 0.6481127866 0.8982938
## HDL_D 1.0315643 0.07091303 0.43823301 0.6612173782 0.8963323
## M_LDL_TG 0.9697489 0.07017947 -0.43770756 0.6615982892 0.8438614
## TotCho 1.0314329 0.07085432 0.43679789 0.6622579309 0.8974250
## IDL_TG 0.9710313 0.07117092 -0.41304236 0.6795755789 0.8426600
## S_VLDL_PL_. 1.0287524 0.06871204 0.41254514 0.6799398999 0.8964114
## S_HDL_L 1.0295712 0.07235618 0.40276382 0.6871219761 0.8962481
## Ace 1.0262474 0.06486438 0.39943073 0.6895758526 0.8812998
## M_HDL_CE_. 0.9730323 0.07090723 -0.38554584 0.6998330516 0.8487361
## S_VLDL_L 1.0275020 0.07044136 0.38515207 0.7001247521 0.8934384
## XS_VLDL_TG 1.0269677 0.06992485 0.38055812 0.7035311646 0.8935623
## L_VLDL_PL_. 1.0273198 0.07203291 0.37417941 0.7082708387 0.8960688
## XL_HDL_PL 1.0254813 0.07059806 0.35641280 0.7215314464 0.8908739
## XL_HDL_CE 1.0223285 0.07061428 0.31272524 0.7544894163 0.8891535
## XS_VLDL_CE_. 1.0206976 0.07064132 0.29000471 0.7718126336 0.8898600
## Crea 1.0193018 0.07115610 0.26867539 0.7881794922 0.8845866
## S_LDL_TG 1.0186270 0.07017191 0.26300642 0.7925456283 0.8862853
## S_VLDL_FC 1.0182151 0.07007102 0.25761211 0.7967062800 0.8859433
## FAw6 0.9826252 0.07000296 -0.25038236 0.8022916661 0.8557952
## SM 0.9829757 0.07111637 -0.24144793 0.8092079701 0.8548078
## XL_VLDL_TG_. 1.0174163 0.07196318 0.23993365 0.8103816925 0.8818192
## Ala 1.0160140 0.06938103 0.22898374 0.8188815552 0.8855694
## L_HDL_C_. 1.0159048 0.07191819 0.21941142 0.8263295721 0.8842423
## M_HDL_PL_. 0.9840732 0.07374158 -0.21771908 0.8276479941 0.8492078
## ApoB 0.9857305 0.07048802 -0.20389694 0.8384340388 0.8573957
## Gly 0.9858102 0.07151121 -0.19984867 0.8415989343 0.8539962
## L_LDL_TG 0.9860798 0.07061017 -0.19852695 0.8426327997 0.8566759
## LA 0.9878156 0.06950054 -0.17639119 0.8599866249 0.8612650
## Remnant_C 0.9877969 0.07015711 -0.17500910 0.8610724864 0.8597854
## XL_HDL_C_. 1.0123843 0.07357616 0.16728640 0.8671447081 0.8743794
## XL_HDL_CE_. 0.9883775 0.07403835 -0.15789876 0.8745365743 0.8526868
## LDL_TG 0.9935902 0.07005635 -0.09179002 0.9268648765 0.8642334
## bOHBut 1.0017780 0.07132848 0.02490526 0.9801305304 0.8611909
## 97.5 % p sig
## S_HDL_PL_. 1.4531919 0.0004345208 yes
## M_LDL_C_. 0.9225448 0.0010358492 yes
## S_HDL_CE_. 0.9169738 0.0010763986 yes
## M_LDL_PL_. 1.3902346 0.0011009212 yes
## S_LDL_PL_. 1.3919638 0.0011014705 yes
## S_HDL_C_. 0.9186881 0.0011776547 yes
## S_LDL_C_. 0.9256064 0.0012330483 yes
## S_LDL_CE_. 0.9251480 0.0012449916 yes
## M_LDL_CE_. 0.9288166 0.0015753934 no
## PUFA.FA 0.9321204 0.0026286394 no
## XS_VLDL_FC_. 0.9397299 0.0033914465 no
## S_HDL_FC_. 1.4069679 0.0037626428 no
## DHA.FA 0.9334814 0.0052649608 no
## XS_VLDL_PL_. 0.9488961 0.0053431014 no
## L_VLDL_CE_. 0.9445851 0.0062998233 no
## UnSat 0.9490082 0.0068040237 no
## S_HDL_CE 0.9531692 0.0071974455 no
## SFA.FA 1.3781593 0.0072413743 no
## FAw3.FA 0.9434999 0.0078848915 no
## S_LDL_TG_. 1.3427806 0.0094756611 no
## M_LDL_TG_. 1.3458232 0.0096927428 no
## LDL_D 1.3635372 0.0120805085 no
## S_HDL_PL 1.3662946 0.0136171478 no
## FAw6.FA 0.9723767 0.0169514723 no
## XL_VLDL_CE_. 0.9629818 0.0192806389 no
## Leu 1.3591917 0.0194352141 no
## Ile 1.3514185 0.0200250784 no
## S_LDL_FC_. 1.3365781 0.0203565586 no
## S_HDL_C 0.9788394 0.0213334398 no
## IDL_FC_. 0.9828196 0.0221801604 no
## S_LDL_CE 0.9765737 0.0222790684 no
## M_LDL_FC_. 1.3298733 0.0224027271 no
## M_HDL_PL 1.3287028 0.0235185966 no
## Alb 1.3516372 0.0236052823 no
## XXL_VLDL_CE_. 0.9619682 0.0239784560 no
## M_VLDL_FC_. 1.4048086 0.0241382381 no
## M_HDL_P 1.3289465 0.0246497566 no
## L_LDL_C_. 0.9882131 0.0256935692 no
## S_VLDL_CE_. 0.9831714 0.0270903146 no
## M_HDL_TG 1.3369343 0.0277634211 no
## MUFA.FA 1.3257431 0.0282556468 no
## HDL_TG 1.3234657 0.0296169731 no
## S_LDL_C 0.9849828 0.0302653200 no
## Val 1.3395657 0.0305260075 no
## M_LDL_CE 0.9867880 0.0325389769 no
## M_HDL_L 1.3195865 0.0327415981 no
## VLDL_D 1.3408742 0.0327512408 no
## XXL_VLDL_FC 1.3176780 0.0350965496 no
## S_VLDL_C_. 0.9911246 0.0364484229 no
## L_VLDL_FC_. 1.4012405 0.0373717069 no
## M_LDL_C 0.9925091 0.0396081880 no
## XXL_VLDL_PL 1.3148224 0.0396821220 no
## XXL_VLDL_TG 1.3149674 0.0400118477 no
## XL_VLDL_TG 1.3118930 0.0430142331 no
## XXL_VLDL_L 1.3112999 0.0441906113 no
## XL_HDL_TG 1.3077034 0.0446458200 no
## IDL_PL_. 0.9990023 0.0446743727 no
## L_LDL_TG_. 1.2789870 0.0448688851 no
## LA.FA 0.9990912 0.0457049351 no
## XS_VLDL_TG_. 1.3045362 0.0472454417 no
## XL_VLDL_P 1.3067239 0.0499569125 no
## XXL_VLDL_C_. 0.9896736 0.0503322221 no
## XL_VLDL_L 1.3058604 0.0511121557 no
## L_LDL_PL_. 1.2681981 0.0536491095 no
## XL_VLDL_PL 1.3029561 0.0556159977 no
## AcAce 1.2559779 0.0601301228 no
## XL_VLDL_FC 1.2996040 0.0602161330 no
## L_LDL_FC_. 1.0101790 0.0607047915 no
## L_VLDL_FC 1.2976542 0.0644956256 no
## L_VLDL_TG 1.2981506 0.0647403697 no
## XL_HDL_TG_. 1.2896022 0.0651507827 no
## S_VLDL_TG_. 1.3072368 0.0654099595 no
## Tyr 1.3003710 0.0663700927 no
## LDL_C 1.0107007 0.0719744231 no
## S_LDL_L 1.0112640 0.0726500842 no
## M_LDL_L 1.0115634 0.0736322261 no
## L_VLDL_P 1.2931188 0.0741545582 no
## L_VLDL_L 1.2926710 0.0750932779 no
## XS_VLDL_FC 1.0128628 0.0773852433 no
## L_VLDL_PL 1.2909829 0.0783760480 no
## M_LDL_P 1.0140006 0.0793408775 no
## M_HDL_CE 1.2895035 0.0803857223 no
## XXL_VLDL_C 1.2885417 0.0804304877 no
## S_LDL_P 1.0151828 0.0818913240 no
## S_HDL_FC 1.3046268 0.0832842241 no
## L_HDL_TG 1.2817249 0.0834168128 no
## XL_VLDL_C 1.2867109 0.0846713368 no
## M_HDL_C 1.2853760 0.0888366233 no
## L_LDL_FC 1.0207157 0.0962601633 no
## Gln 1.2830503 0.0973815023 no
## IDL_FC 1.0230946 0.1025910440 no
## M_LDL_FC 1.0233392 0.1032450331 no
## M_VLDL_PL_. 1.0223934 0.1054942682 no
## L_VLDL_C 1.2787261 0.1061636479 no
## S_LDL_FC 1.0251421 0.1082249801 no
## DHA 1.0245135 0.1129502368 no
## L_LDL_CE_. 1.0287318 0.1131534553 no
## XL_VLDL_CE 1.2745393 0.1144277905 no
## XL_HDL_FC_. 1.2965743 0.1170560495 no
## XXL_VLDL_PL_. 1.3733147 0.1182442854 no
## XS_VLDL_PL 1.0277956 0.1184329813 no
## TG.PG 1.2806269 0.1228680960 no
## XXL_VLDL_TG_. 1.3468347 0.1239274215 no
## VLDL_TG 1.2725249 0.1284522193 no
## L_LDL_C 1.0343237 0.1410384036 no
## MUFA 1.2654139 0.1411248307 no
## Serum_TG 1.2667874 0.1435870697 no
## M_HDL_FC 1.2661464 0.1441704729 no
## XL_VLDL_PL_. 1.3269302 0.1446422850 no
## M_VLDL_TG 1.2674167 0.1464727389 no
## XL_VLDL_FC_. 1.3119714 0.1495710716 no
## Cit 1.2659920 0.1528919612 no
## SFA 1.2636667 0.1544281399 no
## L_LDL_CE 1.0384182 0.1571104859 no
## Glc 1.2565407 0.1636939849 no
## XXL_VLDL_CE 1.2586015 0.1646893653 no
## M_VLDL_CE_. 1.0400150 0.1660263789 no
## IDL_CE_. 1.2809013 0.1661585530 no
## IDL_PL 1.0410809 0.1667404930 no
## M_VLDL_FC 1.2599250 0.1698047876 no
## L_LDL_L 1.0422556 0.1727341704 no
## L_VLDL_CE 1.2557777 0.1800319795 no
## M_VLDL_P 1.2577732 0.1812215544 no
## XL_VLDL_C_. 1.0490234 0.1868015359 no
## M_VLDL_L 1.2558395 0.1884714089 no
## L_LDL_P 1.0461440 0.1900482454 no
## M_VLDL_PL 1.2510531 0.2087207283 no
## IDL_TG_. 1.2411189 0.2143957491 no
## L_LDL_PL 1.0547762 0.2319066180 no
## FAw3 1.0550226 0.2349247143 no
## Glol 1.6467243 0.2431340030 no
## XXL_VLDL_FC_. 1.2359714 0.2674192866 no
## M_VLDL_TG_. 1.2400206 0.2722662629 no
## S_VLDL_CE 1.0616510 0.2746268171 no
## IDL_C 1.0626171 0.2770133413 no
## XS_VLDL_C 1.0629847 0.2804097005 no
## His 1.2440749 0.2830946231 no
## IDL_L 1.0657435 0.2970805623 no
## L_HDL_CE 1.2273432 0.3084415079 no
## M_VLDL_C 1.2293686 0.3109052593 no
## ApoA1 1.2276313 0.3139751982 no
## L_HDL_P 1.2267845 0.3175091349 no
## Gp 1.2291078 0.3185439257 no
## L_HDL_FC_. 1.0761308 0.3243374821 no
## L_HDL_L 1.2241492 0.3335000243 no
## TotFA 1.2257668 0.3357348097 no
## S_VLDL_TG 1.2255662 0.3366272008 no
## IDL_P 1.0720183 0.3380677772 no
## XS_VLDL_L 1.0721440 0.3382687527 no
## XS_VLDL_C_. 1.0741953 0.3390850373 no
## L_HDL_CE_. 1.2360100 0.3584213562 no
## L_HDL_C 1.2194739 0.3598629025 no
## M_VLDL_C_. 1.0745758 0.3616961756 no
## M_LDL_PL 1.0756804 0.3632793547 no
## L_HDL_PL 1.2204546 0.3644229729 no
## S_HDL_TG 1.2216000 0.3744689494 no
## Serum_C 1.0774558 0.3746584806 no
## XL_HDL_FC 1.2132420 0.4013348552 no
## IDL_CE 1.0812282 0.4027297145 no
## M_HDL_TG_. 1.2134894 0.4072706177 no
## XS_VLDL_P 1.0827805 0.4143352638 no
## L_VLDL_C_. 1.0869619 0.4272028213 no
## S_LDL_PL 1.0852603 0.4287081991 no
## PC 1.2115622 0.4356933697 no
## XL_HDL_PL_. 1.0931832 0.4388575367 no
## EstC 1.0871671 0.4454819330 no
## HDL3_C 1.0892476 0.4582676784 no
## S_HDL_TG_. 1.2075469 0.4619836249 no
## XS_VLDL_CE 1.0899655 0.4724655762 no
## Lac 1.1832949 0.4742604006 no
## FreeC 1.0930804 0.4908633727 no
## HDL2_C 1.2011638 0.5005086053 no
## IDL_C_. 1.0981402 0.5133542966 no
## TotPG 1.2019833 0.5150824999 no
## L_HDL_PL_. 1.0977386 0.5240588004 no
## M_VLDL_CE 1.1970500 0.5251288984 no
## S_VLDL_C 1.0971153 0.5344001615 no
## Phe 1.2004717 0.5423860834 no
## M_HDL_FC_. 1.1052401 0.5450938525 no
## L_HDL_FC 1.1948737 0.5526998951 no
## L_HDL_TG_. 1.2005404 0.5537118968 no
## S_HDL_P 1.2043084 0.5642464678 no
## Pyr 1.0812870 0.5733685006 no
## HDL_C 1.1923492 0.5758918191 no
## ApoB.ApoA1 1.1039690 0.5767120088 no
## XL_HDL_P 1.1874437 0.6026003387 no
## XL_HDL_L 1.1870837 0.6063787929 no
## L_VLDL_TG_. 1.1821972 0.6086116287 no
## S_VLDL_P 1.1865592 0.6228465924 no
## M_HDL_C_. 1.1125496 0.6248840425 no
## S_VLDL_PL 1.1856182 0.6263363901 no
## PUFA 1.1096824 0.6409178035 no
## S_VLDL_FC_. 1.1128460 0.6430285774 no
## VLDL_C 1.1841892 0.6454664134 no
## XL_HDL_C 1.1838419 0.6481127866 no
## HDL_D 1.1837322 0.6612173782 no
## M_LDL_TG 1.1110784 0.6615982892 no
## TotCho 1.1847208 0.6622579309 no
## IDL_TG 1.1138309 0.6795755789 no
## S_VLDL_PL_. 1.1737861 0.6799398999 no
## S_HDL_L 1.1884594 0.6871219761 no
## Ace 1.1481694 0.6895758526 no
## M_HDL_CE_. 1.1207456 0.6998330516 no
## S_VLDL_L 1.1777124 0.7001247521 no
## XS_VLDL_TG 1.1754754 0.7035311646 no
## L_VLDL_PL_. 1.1883175 0.7082708387 no
## XL_HDL_PL 1.1750816 0.7215314464 no
## XL_HDL_CE 1.1727524 0.7544894163 no
## XS_VLDL_CE_. 1.1738576 0.7718126336 no
## Crea 1.1692258 0.7881794922 no
## S_LDL_TG 1.1669765 0.7925456283 no
## S_VLDL_FC 1.1661177 0.7967062800 no
## FAw6 1.1261543 0.8022916661 no
## SM 1.1297075 0.8092079701 no
## XL_VLDL_TG_. 1.1689489 0.8103816925 no
## Ala 1.1624033 0.8188815552 no
## L_HDL_C_. 1.1723792 0.8263295721 no
## M_HDL_PL_. 1.1337552 0.8276479941 no
## ApoB 1.1304286 0.8384340388 no
## Gly 1.1301098 0.8415989343 no
## L_LDL_TG 1.1299856 0.8426327997 no
## LA 1.1311079 0.8599866249 no
## Remnant_C 1.1321081 0.8610724864 no
## XL_HDL_C_. 1.1668472 0.8671447081 no
## XL_HDL_CE_. 1.1399344 0.8745365743 no
## LDL_TG 1.1374846 0.9268648765 no
## bOHBut 1.1392566 0.9801305304 no
# Sorted list of stage results
copy_result3 = copy_result3[order(copy_result3$'Pr(>|z|)'),]
# head(copy_result3)
copy_result3$sig <- ifelse(copy_result3$'Pr(>|z|)'<0.0013,"yes","no")
copy_result3 ## Estimate Std. Error z value Pr(>|z|) 2.5 %
## S_LDL_C_. 0.7639523 0.05932285 -4.53872150 5.659633e-06 0.6811385
## M_LDL_C_. 0.7652463 0.05968286 -4.48298744 7.360526e-06 0.6818871
## S_LDL_PL_. 1.3013115 0.06009095 4.38289885 1.171105e-05 1.1542833
## M_LDL_PL_. 1.2984614 0.05974801 4.37135887 1.234757e-05 1.1521289
## S_LDL_CE_. 0.7694895 0.05997692 -4.36881408 1.249231e-05 0.6852225
## M_LDL_CE_. 0.7720106 0.06037951 -4.28550964 1.823207e-05 0.6870158
## S_LDL_TG_. 1.2786234 0.06059602 4.05610781 4.989724e-05 1.1326712
## S_HDL_PL_. 1.2903603 0.06524938 3.90687905 9.349592e-05 1.1342000
## S_HDL_CE_. 0.7779636 0.06429221 -3.90522427 9.413804e-05 0.6866474
## S_HDL_C_. 0.7784841 0.06424440 -3.89772134 9.710206e-05 0.6871992
## M_LDL_TG_. 1.2654739 0.06169939 3.81602965 1.356162e-04 1.1187111
## IDL_FC_. 0.7948662 0.06056813 -3.79046691 1.503644e-04 0.7068951
## FAw6.FA 0.7857382 0.06532815 -3.69108290 2.233013e-04 0.6918132
## XS_VLDL_FC_. 0.7925606 0.06349580 -3.66144276 2.507989e-04 0.7009618
## LA.FA 0.7991341 0.06343831 -3.53455949 4.084555e-04 0.7063140
## S_LDL_CE 0.7842965 0.06901247 -3.52064018 4.305064e-04 0.6845348
## IDL_FC 0.7866382 0.06878193 -3.48909815 4.846532e-04 0.6870092
## PUFA.FA 0.7965040 0.06556092 -3.47040707 5.196701e-04 0.7009758
## XS_VLDL_PL_. 0.8023853 0.06352426 -3.46586369 5.285312e-04 0.7098743
## S_HDL_PL 1.2626128 0.06728461 3.46562517 5.290002e-04 1.1059736
## M_LDL_CE 0.7890932 0.06913931 -3.42599366 6.125547e-04 0.6884841
## S_LDL_C 0.7919632 0.06871678 -3.39422637 6.882278e-04 0.6916745
## L_LDL_FC 0.7921062 0.06897827 -3.37874323 7.281798e-04 0.6914165
## S_VLDL_CE_. 0.8000750 0.06646889 -3.35570180 7.916388e-04 0.7023492
## M_LDL_C 0.7960383 0.06881429 -3.31483396 9.169757e-04 0.6950391
## LDL_C 0.7990626 0.06905622 -3.24830882 1.160932e-03 0.6972372
## S_VLDL_C_. 0.8054295 0.06688101 -3.23529236 1.215182e-03 0.7064406
## S_HDL_FC_. 1.2358747 0.06715104 3.15377055 1.611758e-03 1.0828322
## XS_VLDL_TG_. 1.2202620 0.06411581 3.10478133 1.904197e-03 1.0740198
## L_VLDL_CE_. 0.8044192 0.07029413 -3.09605829 1.961118e-03 0.7001920
## IDL_PL 0.8075341 0.06908791 -3.09417380 1.973618e-03 0.7046888
## Glc 1.2070744 0.06090142 3.09023357 1.999991e-03 1.0669014
## L_LDL_C 0.8077402 0.06915800 -3.08734736 2.019515e-03 0.7046240
## XS_VLDL_FC 0.8070293 0.06982955 -3.07026720 2.138673e-03 0.7029685
## L_LDL_C_. 0.8389205 0.05734985 -3.06259456 2.194271e-03 0.7507106
## S_HDL_CE 0.8208022 0.06575724 -3.00306211 2.672779e-03 0.7225033
## M_LDL_FC_. 1.2109301 0.06409014 2.98624237 2.824287e-03 1.0657041
## L_LDL_CE 0.8143519 0.06912583 -2.97085292 2.969740e-03 0.7103973
## M_LDL_L 0.8179774 0.06838810 -2.93794548 3.303951e-03 0.7148270
## L_LDL_TG_. 1.1892544 0.05900418 2.93753010 3.308381e-03 1.0561622
## IDL_TG_. 1.2012576 0.06256925 2.93065733 3.382457e-03 1.0601781
## L_LDL_L 0.8166586 0.06926834 -2.92390658 3.456685e-03 0.7121971
## IDL_PL_. 0.8261515 0.06532900 -2.92331194 3.463294e-03 0.7278254
## M_LDL_P 0.8204981 0.06841237 -2.89192936 3.828840e-03 0.7169840
## Tyr 1.2077866 0.06532840 2.88985263 3.854225e-03 1.0612038
## L_LDL_P 0.8211624 0.06928985 -2.84362494 4.460352e-03 0.7160680
## IDL_C 0.8224276 0.06882602 -2.84042094 4.505404e-03 0.7179753
## S_LDL_L 0.8242195 0.06815142 -2.83660087 4.559657e-03 0.7207191
## S_VLDL_TG_. 1.2115757 0.06770158 2.83481958 4.585157e-03 1.0611453
## L_LDL_PL 0.8219225 0.06938892 -2.82623157 4.709920e-03 0.7166043
## UnSat 0.8265575 0.06752248 -2.82107266 4.786336e-03 0.7240975
## XS_VLDL_PL 0.8217563 0.06986864 -2.80972026 4.958458e-03 0.7156976
## IDL_L 0.8251374 0.06900599 -2.78534316 5.347110e-03 0.7199322
## XL_VLDL_TG 1.2005352 0.06581148 2.77713591 5.484024e-03 1.0520105
## M_LDL_FC 0.8319114 0.06672747 -2.75792406 5.816971e-03 0.7298170
## XXL_VLDL_FC 1.1982009 0.06563201 2.75507689 5.867834e-03 1.0501235
## S_LDL_FC 0.8324992 0.06673771 -2.74691720 6.015832e-03 0.7303769
## VLDL_D 1.2073774 0.06880768 2.73880186 6.166352e-03 1.0549310
## S_LDL_P 0.8302084 0.06814240 -2.73073013 6.319420e-03 0.7259619
## MUFA.FA 1.1925912 0.06488970 2.71427330 6.642134e-03 1.0487779
## XXL_VLDL_TG 1.1940293 0.06604746 2.68494107 7.254259e-03 1.0455133
## S_HDL_FC 1.2020542 0.06875973 2.67644885 7.440692e-03 1.0503336
## SFA.FA 1.1945693 0.06642657 2.67642414 7.441241e-03 1.0483269
## XXL_VLDL_PL 1.1930262 0.06595493 2.67596573 7.451427e-03 1.0448484
## XL_VLDL_P 1.1919277 0.06602216 2.65928794 7.830601e-03 1.0440008
## IDL_P 0.8326936 0.06897332 -2.65449845 7.942640e-03 0.7265414
## L_VLDL_TG 1.1910539 0.06613800 2.64354140 8.204373e-03 1.0432920
## XL_VLDL_L 1.1895298 0.06607336 2.62674853 8.620501e-03 1.0417860
## XXL_VLDL_L 1.1869212 0.06619721 2.58867028 9.634730e-03 1.0390010
## XS_VLDL_C 0.8374291 0.06907885 -2.56834936 1.021841e-02 0.7304852
## L_VLDL_FC 1.1843857 0.06618083 2.55699806 1.055798e-02 1.0372661
## XL_VLDL_PL 1.1825178 0.06626821 2.52980842 1.141248e-02 1.0351579
## Serum_C 0.8410361 0.06850368 -2.52717452 1.149843e-02 0.7346284
## L_VLDL_P 1.1822015 0.06634726 2.52276196 1.164372e-02 1.0351183
## IDL_CE 0.8414479 0.06865466 -2.51448534 1.192063e-02 0.7348037
## L_VLDL_L 1.1810882 0.06638118 2.50728079 1.216640e-02 1.0340804
## L_LDL_PL_. 1.1583036 0.05895952 2.49249790 1.268481e-02 1.0284866
## TG.PG 1.1819934 0.06747138 2.47812254 1.320758e-02 1.0338216
## XL_HDL_TG_. 1.1702039 0.06392345 2.45884719 1.393839e-02 1.0294055
## L_VLDL_PL 1.1771303 0.06645679 2.45391804 1.413092e-02 1.0304372
## XL_VLDL_CE_. 0.8173584 0.08319408 -2.42418162 1.534293e-02 0.6914043
## EstC 0.8471917 0.06856496 -2.41855742 1.558219e-02 0.7399407
## S_LDL_FC_. 1.1716347 0.06549751 2.41841223 1.558841e-02 1.0286809
## Ile 1.1777450 0.06771108 2.41617185 1.568466e-02 1.0298165
## S_HDL_C 0.8526251 0.06629499 -2.40493747 1.617523e-02 0.7498942
## L_LDL_FC_. 0.8575064 0.06425767 -2.39234599 1.674105e-02 0.7579471
## XL_VLDL_FC 1.1718091 0.06644105 2.38630853 1.701847e-02 1.0253911
## M_VLDL_CE_. 0.8508716 0.06872868 -2.34973360 1.878685e-02 0.7426727
## Leu 1.1745178 0.06861587 2.34432166 1.906172e-02 1.0251013
## FreeC 0.8514607 0.06898305 -2.33103569 1.975148e-02 0.7429756
## Val 1.1688087 0.06744616 2.31273453 2.073724e-02 1.0231450
## M_VLDL_TG_. 1.1687471 0.06802312 2.29234259 2.188588e-02 1.0241112
## S_HDL_TG 1.1653941 0.06697092 2.28545914 2.228592e-02 1.0208062
## VLDL_TG 1.1650236 0.06684583 2.28497904 2.231406e-02 1.0194469
## L_LDL_CE_. 0.8731384 0.05949027 -2.28039260 2.258441e-02 0.7784846
## XS_VLDL_CE 0.8563791 0.06854781 -2.26181021 2.370913e-02 0.7478890
## M_VLDL_TG 1.1630760 0.06699724 2.25484237 2.414322e-02 1.0174957
## M_VLDL_C_. 0.8593399 0.06750009 -2.24578522 2.471777e-02 0.7521300
## XL_VLDL_C_. 0.8475054 0.07454475 -2.21958078 2.644724e-02 0.7319539
## XL_VLDL_C 1.1567680 0.06674068 2.18202662 2.910757e-02 1.0117446
## Gln 0.8650689 0.06651756 -2.17906629 2.932674e-02 0.7590987
## IDL_C_. 0.8703159 0.06397409 -2.17117560 2.991790e-02 0.7692086
## L_VLDL_C 1.1558223 0.06685306 2.16612384 3.030172e-02 1.0111052
## XS_VLDL_C_. 0.8697314 0.06552408 -2.13006919 3.316590e-02 0.7659367
## L_VLDL_C_. 0.8745096 0.06323269 -2.12061306 3.395438e-02 0.7743820
## XXL_VLDL_CE_. 0.8306350 0.08786671 -2.11188995 3.469589e-02 0.6929862
## Serum_TG 1.1508441 0.06685552 2.10148226 3.559865e-02 1.0071237
## S_VLDL_CE 0.8660373 0.06864848 -2.09512646 3.615975e-02 0.7559892
## XXL_VLDL_C_. 0.8352124 0.08600183 -2.09378339 3.627928e-02 0.6999717
## XXL_VLDL_C 1.1479790 0.06701798 2.05919351 3.947570e-02 1.0034497
## XS_VLDL_L 0.8674010 0.06921942 -2.05511568 3.986783e-02 0.7562371
## XL_VLDL_CE 1.1422882 0.06697567 1.98629487 4.700059e-02 0.9987443
## M_VLDL_P 1.1427281 0.06738106 1.98005931 4.769687e-02 0.9990248
## M_HDL_TG 1.1433637 0.06783700 1.97494749 4.827411e-02 0.9998972
## M_VLDL_FC 1.1413257 0.06718712 1.96749779 4.912585e-02 0.9982030
## Gly 0.8686245 0.07269674 -1.93742400 5.269354e-02 0.7511558
## XXL_VLDL_TG_. 1.1695693 0.08092322 1.93560677 5.291588e-02 1.0040764
## HDL_TG 1.1368854 0.06648466 1.92965391 5.364973e-02 0.9962151
## M_VLDL_L 1.1386794 0.06742541 1.92611653 5.408982e-02 0.9954145
## M_LDL_PL 0.8838967 0.06692771 -1.84400623 6.518223e-02 0.7751098
## SM 0.8830059 0.06847485 -1.81706774 6.920674e-02 0.7717653
## S_HDL_TG_. 1.1288218 0.06669913 1.81673133 6.925826e-02 0.9885764
## M_VLDL_PL 1.1304719 0.06754851 1.81551206 6.944526e-02 0.9880537
## XS_VLDL_P 0.8839338 0.06901294 -1.78768044 7.382758e-02 0.7709553
## L_HDL_FC_. 0.8875640 0.06693163 -1.78203762 7.474310e-02 0.7802080
## M_VLDL_PL_. 0.8851901 0.06874607 -1.77396186 7.606946e-02 0.7719546
## L_VLDL_CE 1.1215249 0.06739420 1.70176838 8.879880e-02 0.9802605
## L_VLDL_TG_. 1.1137485 0.06350105 1.69652919 8.978571e-02 0.9804615
## Gp 1.1191993 0.06722014 1.67529386 9.387659e-02 0.9796932
## S_VLDL_TG 1.1172335 0.06717411 1.65027130 9.888746e-02 0.9776900
## L_HDL_CE_. 1.1214585 0.07048706 1.62625672 1.038951e-01 0.9787167
## MUFA 1.1106471 0.06720303 1.56157906 1.183872e-01 0.9714929
## M_HDL_FC_. 0.9044161 0.06507481 -1.54385048 1.226246e-01 0.7991586
## S_HDL_P 1.1145195 0.07052045 1.53747440 1.241772e-01 0.9715454
## HDL3_C 0.9030561 0.06771115 -1.50596475 1.320762e-01 0.7902463
## XL_HDL_TG 1.1055426 0.06726209 1.49172063 1.357724e-01 0.9665356
## S_LDL_PL 0.9081990 0.06665824 -1.44455901 1.485818e-01 0.7973032
## M_HDL_P 1.0969790 0.06554286 1.41220578 1.578894e-01 0.9633787
## XXL_VLDL_CE 1.0990540 0.06796403 1.38970262 1.646192e-01 0.9590891
## M_HDL_PL 1.0944723 0.06540724 1.38015793 1.675380e-01 0.9613339
## LA 0.9120817 0.06745083 -1.36433823 1.724611e-01 0.7984064
## XL_HDL_PL_. 0.9137359 0.06795340 -1.32758172 1.843163e-01 0.8017629
## FAw6 0.9141513 0.06799657 -1.32005457 1.868168e-01 0.7992635
## XL_VLDL_TG_. 1.0922372 0.06774760 1.30230587 1.928118e-01 0.9545094
## Phe 1.0906158 0.06745905 1.28585452 1.984938e-01 0.9542800
## S_HDL_L 1.0944301 0.07037550 1.28217638 1.997808e-01 0.9545793
## AcAce 1.0798931 0.06037472 1.27308400 2.029882e-01 0.9531123
## M_HDL_L 1.0868063 0.06567477 1.26750877 2.049734e-01 0.9542202
## Remnant_C 0.9177778 0.06854283 -1.25177220 2.106529e-01 0.8013639
## S_VLDL_C 0.9183044 0.06823580 -1.24899713 2.116661e-01 0.8022122
## LDL_D 1.0862373 0.06704848 1.23372967 2.173037e-01 0.9519502
## SFA 1.0863278 0.06793815 1.21880028 2.229200e-01 0.9490593
## M_VLDL_C 1.0852834 0.06793422 1.20471232 2.283144e-01 0.9479600
## PUFA 0.9275101 0.06808760 -1.10521700 2.690656e-01 0.8107279
## S_VLDL_FC_. 0.9278339 0.06967096 -1.07509005 2.823344e-01 0.8084480
## ApoB 0.9298526 0.06870052 -1.05864113 2.897632e-01 0.8116567
## IDL_CE_. 1.0779410 0.07103394 1.05657526 2.907055e-01 0.9380689
## M_HDL_CE 1.0704457 0.06616338 1.02889437 3.035293e-01 0.9392354
## Crea 0.9322973 0.06927565 -1.01194999 3.115620e-01 0.8115533
## M_HDL_TG_. 1.0693108 0.06781024 0.98826319 3.230238e-01 0.9341895
## Pyr 1.0472539 0.04893236 0.94357685 3.453859e-01 0.9356037
## M_HDL_C 1.0621012 0.06623558 0.90962022 3.630228e-01 0.9317702
## TotCho 0.9429591 0.06809321 -0.86252948 3.883962e-01 0.8248550
## M_VLDL_FC_. 1.0593946 0.06861087 0.84093949 4.003818e-01 0.9299260
## XXL_VLDL_PL_. 1.0701529 0.08232871 0.82354619 4.101975e-01 0.9148121
## M_HDL_C_. 0.9465630 0.06771342 -0.81103250 4.173470e-01 0.8305115
## ApoB.ApoA1 0.9461123 0.06833622 -0.81060978 4.175898e-01 0.8269628
## XL_HDL_PL 0.9458448 0.06916011 -0.80504164 4.207956e-01 0.8241113
## L_HDL_PL_. 0.9462202 0.06871611 -0.80446810 4.211267e-01 0.8258823
## S_LDL_TG 1.0546779 0.06704078 0.79407534 4.271516e-01 0.9235084
## XL_HDL_FC_. 1.0546812 0.06889510 0.77274798 4.396715e-01 0.9237603
## L_VLDL_FC_. 1.0562200 0.07101981 0.77015809 4.412061e-01 0.9234073
## XL_VLDL_PL_. 1.0575203 0.07368309 0.75901835 4.478416e-01 0.9210114
## S_VLDL_P 1.0526257 0.06772132 0.75733514 4.488491e-01 0.9203601
## DHA.FA 0.9495403 0.06995273 -0.74017614 4.591931e-01 0.8252652
## TotFA 1.0510824 0.06824129 0.73006325 4.653515e-01 0.9179885
## Cit 1.0486937 0.06767962 0.70250528 4.823641e-01 0.9175733
## XS_VLDL_TG 1.0479160 0.06687517 0.69986259 4.840131e-01 0.9175341
## PC 0.9536396 0.06795504 -0.69854229 4.848381e-01 0.8341014
## S_VLDL_PL 1.0468423 0.06755802 0.67761479 4.980160e-01 0.9155712
## XS_VLDL_CE_. 0.9557436 0.06681616 -0.67746443 4.981113e-01 0.8393023
## XL_HDL_CE 0.9555393 0.06800458 -0.66876943 5.036426e-01 0.8353759
## XL_HDL_L 0.9553166 0.06852065 -0.66713399 5.046865e-01 0.8335937
## XL_HDL_P 0.9562489 0.06852207 -0.65288559 5.138300e-01 0.8343789
## XL_HDL_C 0.9576835 0.06810994 -0.63482556 5.255422e-01 0.8368916
## S_VLDL_PL_. 1.0419581 0.06525163 0.62989554 5.287629e-01 0.9144425
## XL_HDL_C_. 1.0437952 0.06923414 0.61910687 5.358460e-01 0.9094023
## HDL_D 0.9590222 0.06866987 -0.60930763 5.423205e-01 0.8370303
## L_HDL_TG_. 1.0432493 0.07003980 0.60451554 5.455009e-01 0.9065445
## L_LDL_TG 0.9598365 0.06832770 -0.59993648 5.485486e-01 0.8378069
## S_VLDL_L 1.0391216 0.06777042 0.56626055 5.712167e-01 0.9084990
## Lac 1.0368246 0.06529491 0.55383761 5.796900e-01 0.9045855
## XL_HDL_FC 0.9664029 0.06823633 -0.50082494 6.164943e-01 0.8438905
## L_HDL_FC 0.9661583 0.06892244 -0.49951175 6.174189e-01 0.8423297
## XL_HDL_CE_. 1.0344005 0.06922285 0.48859577 6.251279e-01 0.9011068
## Ace 1.0303853 0.06210287 0.48198687 6.298153e-01 0.8921344
## Alb 1.0319539 0.06672289 0.47141244 6.373462e-01 0.9062222
## HDL_C 0.9692909 0.06808600 -0.45810444 6.468774e-01 0.8469944
## M_HDL_FC 1.0309078 0.06676398 0.45593163 6.484391e-01 0.9035821
## M_LDL_TG 0.9707020 0.06734267 -0.44155965 6.588079e-01 0.8495259
## M_VLDL_CE 1.0303112 0.06828889 0.43727298 6.619134e-01 0.8994085
## M_HDL_CE_. 0.9713475 0.06798617 -0.42760100 6.689416e-01 0.8518992
## bOHBut 1.0251210 0.06251837 0.39685386 6.914752e-01 0.8975608
## FAw3.FA 0.9738794 0.06856616 -0.38601864 6.994829e-01 0.8486516
## LDL_TG 0.9751724 0.06759727 -0.37192372 7.099496e-01 0.8525108
## HDL2_C 0.9753906 0.06796820 -0.36660151 7.139163e-01 0.8524604
## L_HDL_TG 1.0224163 0.06752243 0.32831611 7.426727e-01 0.8937832
## S_VLDL_FC 1.0223055 0.06742602 0.32717941 7.435322e-01 0.8943362
## L_HDL_C_. 1.0219106 0.06868872 0.31553934 7.523522e-01 0.8950103
## M_HDL_PL_. 1.0218202 0.06941470 0.31096471 7.558275e-01 0.8895294
## Glol 1.0391628 0.13450210 0.28561206 7.751753e-01 0.7965224
## His 1.0194013 0.06972151 0.27560372 7.828525e-01 0.8882859
## L_HDL_PL 0.9817815 0.06827081 -0.26931686 7.876859e-01 0.8574614
## Ala 0.9841388 0.06694464 -0.23882942 8.112379e-01 0.8620124
## DHA 0.9847780 0.06884432 -0.22280710 8.236856e-01 0.8572353
## ApoA1 0.9858269 0.06715381 -0.21256379 8.316672e-01 0.8631490
## TotPG 0.9886056 0.06805200 -0.16839727 8.662708e-01 0.8645472
## L_HDL_L 0.9888672 0.06821739 -0.16411137 8.696435e-01 0.8634397
## VLDL_C 1.0112660 0.06857461 0.16336934 8.702276e-01 0.8826296
## L_HDL_P 0.9892384 0.06821752 -0.15860951 8.739765e-01 0.8637738
## FAw3 1.0104323 0.06771941 0.15325421 8.781978e-01 0.8822674
## IDL_TG 0.9911058 0.06788137 -0.13161239 8.952909e-01 0.8658771
## XL_VLDL_FC_. 0.9920529 0.06880488 -0.11596372 9.076813e-01 0.8704947
## L_HDL_C 0.9926431 0.06815051 -0.10834958 9.137184e-01 0.8666984
## L_VLDL_PL_. 0.9957722 0.06704896 -0.06318925 9.496158e-01 0.8766279
## XXL_VLDL_FC_. 1.0015526 0.07039294 0.02203903 9.824168e-01 0.8703843
## L_HDL_CE 1.0009518 0.06790502 0.01400953 9.888224e-01 0.8743745
## 97.5 % p sig
## S_LDL_C_. 0.8600558 5.659633e-06 yes
## M_LDL_C_. 0.8622633 7.360526e-06 yes
## S_LDL_PL_. 1.4617465 1.171105e-05 yes
## M_LDL_PL_. 1.4573381 1.234757e-05 yes
## S_LDL_CE_. 0.8673766 1.249231e-05 yes
## M_LDL_CE_. 0.8710630 1.823207e-05 yes
## S_LDL_TG_. 1.4373642 4.989724e-05 yes
## S_HDL_PL_. 1.4652186 9.349592e-05 yes
## S_HDL_CE_. 0.8838201 9.413804e-05 yes
## S_HDL_C_. 0.8843732 9.710206e-05 yes
## M_LDL_TG_. 1.4256524 1.356162e-04 yes
## IDL_FC_. 0.8972368 1.503644e-04 yes
## FAw6.FA 0.8939304 2.233013e-04 yes
## XS_VLDL_FC_. 0.8996783 2.507989e-04 yes
## LA.FA 0.9060084 4.084555e-04 yes
## S_LDL_CE 0.8972779 4.305064e-04 yes
## IDL_FC 0.8997045 4.846532e-04 yes
## PUFA.FA 0.9065772 5.196701e-04 yes
## XS_VLDL_PL_. 0.9111469 5.285312e-04 yes
## S_HDL_PL 1.4400597 5.290002e-04 yes
## M_LDL_CE 0.9029035 6.125547e-04 yes
## S_LDL_C 0.9055863 6.882278e-04 yes
## L_LDL_FC 0.9061724 7.281798e-04 yes
## S_VLDL_CE_. 0.9115413 7.916388e-04 yes
## M_LDL_C 0.9103385 9.169757e-04 yes
## LDL_C 0.9140845 1.160932e-03 yes
## S_VLDL_C_. 0.9183202 1.215182e-03 yes
## S_HDL_FC_. 1.4091415 1.611758e-03 no
## XS_VLDL_TG_. 1.3814594 1.904197e-03 no
## L_VLDL_CE_. 0.9224074 1.961118e-03 no
## IDL_PL 0.9239553 1.973618e-03 no
## Glc 1.3559202 1.999991e-03 no
## L_LDL_C 0.9241379 2.019515e-03 no
## XS_VLDL_FC 0.9243731 2.138673e-03 no
## L_LDL_C_. 0.9414123 2.194271e-03 no
## S_HDL_CE 0.9352106 2.672779e-03 no
## M_LDL_FC_. 1.3705852 2.824287e-03 no
## L_LDL_CE 0.9315939 2.969740e-03 no
## M_LDL_L 0.9346887 3.303951e-03 no
## L_LDL_TG_. 1.3326071 3.308381e-03 no
## IDL_TG_. 1.3554476 3.382457e-03 no
## L_LDL_L 0.9344746 3.456685e-03 no
## IDL_PL_. 0.9406952 3.463294e-03 no
## M_LDL_P 0.9375974 3.828840e-03 no
## Tyr 1.3713850 3.854225e-03 no
## L_LDL_P 0.9396334 4.460352e-03 no
## IDL_C 0.9404126 4.505404e-03 no
## S_LDL_L 0.9415211 4.559657e-03 no
## S_VLDL_TG_. 1.3838309 4.585157e-03 no
## L_LDL_PL 0.9407029 4.709920e-03 no
## UnSat 0.9435909 4.786336e-03 no
## XS_VLDL_PL 0.9412678 4.958458e-03 no
## IDL_L 0.9436537 5.347110e-03 no
## XL_VLDL_TG 1.3625545 5.484024e-03 no
## M_LDL_FC 0.9481465 5.816971e-03 no
## XXL_VLDL_FC 1.3591896 5.867834e-03 no
## S_LDL_FC 0.9489181 6.015832e-03 no
## VLDL_D 1.3817527 6.166352e-03 no
## S_LDL_P 0.9483333 6.319420e-03 no
## MUFA.FA 1.3528946 6.642134e-03 no
## XXL_VLDL_TG 1.3554495 7.254259e-03 no
## S_HDL_FC 1.3751330 7.440692e-03 no
## SFA.FA 1.3601601 7.441241e-03 no
## XXL_VLDL_PL 1.3540638 7.451427e-03 no
## XL_VLDL_P 1.3532436 7.830601e-03 no
## IDL_P 0.9521962 7.942640e-03 no
## L_VLDL_TG 1.3528318 8.204373e-03 no
## XL_VLDL_L 1.3506295 8.620501e-03 no
## XXL_VLDL_L 1.3477378 9.634730e-03 no
## XS_VLDL_C 0.9577620 1.021841e-02 no
## L_VLDL_FC 1.3452273 1.055798e-02 no
## XL_VLDL_PL 1.3430422 1.141248e-02 no
## Serum_C 0.9610188 1.149843e-02 no
## L_VLDL_P 1.3432792 1.164372e-02 no
## IDL_CE 0.9618087 1.192063e-02 no
## L_VLDL_L 1.3421004 1.216640e-02 no
## L_LDL_PL_. 1.2974302 1.268481e-02 no
## TG.PG 1.3471563 1.320758e-02 no
## XL_HDL_TG_. 1.3232012 1.393839e-02 no
## L_VLDL_PL 1.3377535 1.413092e-02 no
## XL_VLDL_CE_. 0.9576651 1.534293e-02 no
## EstC 0.9682009 1.558219e-02 no
## S_LDL_FC_. 1.3301199 1.558841e-02 no
## Ile 1.3431683 1.568466e-02 no
## S_HDL_C 0.9727112 1.617523e-02 no
## L_LDL_FC_. 0.9762066 1.674105e-02 no
## XL_VLDL_FC 1.3312191 1.701847e-02 no
## M_VLDL_CE_. 0.9722352 1.878685e-02 no
## Leu 1.3417787 1.906172e-02 no
## FreeC 0.9737689 1.975148e-02 no
## Val 1.3330118 2.073724e-02 no
## M_VLDL_TG_. 1.3370859 2.188588e-02 no
## S_HDL_TG 1.3275098 2.228592e-02 no
## VLDL_TG 1.3253323 2.231406e-02 no
## L_LDL_CE_. 0.9844225 2.258441e-02 no
## XS_VLDL_CE 0.9785450 2.370913e-02 no
## M_VLDL_TG 1.3235645 2.414322e-02 no
## M_VLDL_C_. 0.9799431 2.471777e-02 no
## XL_VLDL_C_. 0.9801183 2.644724e-02 no
## XL_VLDL_C 1.3149358 2.910757e-02 no
## Gln 0.9852994 2.932674e-02 no
## IDL_C_. 0.9887663 2.991790e-02 no
## L_VLDL_C 1.3145665 3.030172e-02 no
## XS_VLDL_C_. 0.9904178 3.316590e-02 no
## L_VLDL_C_. 0.9925795 3.395438e-02 no
## XXL_VLDL_CE_. 0.9760231 3.469589e-02 no
## Serum_TG 1.3092918 3.559865e-02 no
## S_VLDL_CE 0.9895133 3.615975e-02 no
## XXL_VLDL_C_. 0.9789995 3.627928e-02 no
## XXL_VLDL_C 1.3055508 3.947570e-02 no
## XS_VLDL_L 0.9920686 3.986783e-02 no
## XL_VLDL_CE 1.2991415 4.700059e-02 no
## M_VLDL_P 1.3014157 4.769687e-02 no
## M_HDL_TG 1.3047365 4.827411e-02 no
## M_VLDL_FC 1.2993495 4.912585e-02 no
## Gly 0.9986646 5.269354e-02 no
## XXL_VLDL_TG_. 1.3767507 5.291588e-02 no
## HDL_TG 1.2931270 5.364973e-02 no
## M_VLDL_L 1.2969255 5.408982e-02 no
## M_LDL_PL 1.0076948 6.518223e-02 no
## SM 1.0094565 6.920674e-02 no
## S_HDL_TG_. 1.2842882 6.925826e-02 no
## M_VLDL_PL 1.2879278 6.944526e-02 no
## XS_VLDL_P 1.0105537 7.382758e-02 no
## L_HDL_FC_. 1.0146001 7.474310e-02 no
## M_VLDL_PL_. 1.0108271 7.606946e-02 no
## L_VLDL_CE 1.2770297 8.879880e-02 no
## L_VLDL_TG_. 1.2580012 8.978571e-02 no
## Gp 1.2752522 9.387659e-02 no
## S_VLDL_TG 1.2724646 9.888746e-02 no
## L_HDL_CE_. 1.2902824 1.038951e-01 no
## MUFA 1.2645885 1.183872e-01 no
## M_HDL_FC_. 1.0320935 1.226246e-01 no
## S_HDL_P 1.2798986 1.241772e-01 no
## HDL3_C 1.0305787 1.320762e-01 no
## XL_HDL_TG 1.2584428 1.357724e-01 no
## S_LDL_PL 1.0354261 1.485818e-01 no
## M_HDL_P 1.2458523 1.578894e-01 no
## XXL_VLDL_CE 1.2522745 1.646192e-01 no
## M_HDL_PL 1.2425601 1.675380e-01 no
## LA 1.0401469 1.724611e-01 no
## XL_HDL_PL_. 1.0467637 1.843163e-01 no
## FAw6 1.0435044 1.868168e-01 no
## XL_VLDL_TG_. 1.2448711 1.928118e-01 no
## Phe 1.2433527 1.984938e-01 no
## S_HDL_L 1.2567004 1.997808e-01 no
## AcAce 1.2096159 2.029882e-01 no
## M_HDL_L 1.2346235 2.049734e-01 no
## Remnant_C 1.0484985 2.106529e-01 no
## S_VLDL_C 1.0483005 2.116661e-01 no
## LDL_D 1.2381520 2.173037e-01 no
## SFA 1.2388923 2.229200e-01 no
## M_VLDL_C 1.2374535 2.283144e-01 no
## PUFA 1.0588527 2.690656e-01 no
## S_VLDL_FC_. 1.0624466 2.823344e-01 no
## ApoB 1.0626232 2.897632e-01 no
## IDL_CE_. 1.2392997 2.907055e-01 no
## M_HDL_CE 1.2175122 3.035293e-01 no
## Crea 1.0636087 3.115620e-01 no
## M_HDL_TG_. 1.2188164 3.230238e-01 no
## Pyr 1.1486584 3.453859e-01 no
## M_HDL_C 1.2081695 3.630228e-01 no
## TotCho 1.0772208 3.883962e-01 no
## M_VLDL_FC_. 1.2171579 4.003818e-01 no
## XXL_VLDL_PL_. 1.2623100 4.101975e-01 no
## M_HDL_C_. 1.0831093 4.173470e-01 no
## ApoB.ApoA1 1.0811299 4.175898e-01 no
## XL_HDL_PL 1.0808573 4.207956e-01 no
## L_HDL_PL_. 1.0811861 4.211267e-01 no
## S_LDL_TG 1.2011807 4.271516e-01 no
## XL_HDL_FC_. 1.2100761 4.396715e-01 no
## L_VLDL_FC_. 1.2203880 4.412061e-01 no
## XL_VLDL_PL_. 1.2300214 4.478416e-01 no
## S_VLDL_P 1.2003300 4.488491e-01 no
## DHA.FA 1.0856365 4.591931e-01 no
## TotFA 1.1997111 4.653515e-01 no
## Cit 1.1964870 4.823641e-01 no
## XS_VLDL_TG 1.1926720 4.840131e-01 no
## PC 1.0887814 4.848381e-01 no
## S_VLDL_PL 1.1933093 4.980160e-01 no
## XS_VLDL_CE_. 1.0907055 4.981113e-01 no
## XL_HDL_CE 1.0906046 5.036426e-01 no
## XL_HDL_L 1.0905169 5.046865e-01 no
## XL_HDL_P 1.0915531 5.138300e-01 no
## XL_HDL_C 1.0930411 5.255422e-01 no
## S_VLDL_PL_. 1.1812706 5.287629e-01 no
## XL_HDL_C_. 1.1931248 5.358460e-01 no
## HDL_D 1.0957105 5.423205e-01 no
## L_HDL_TG_. 1.1932788 5.455009e-01 no
## L_LDL_TG 1.0952220 5.485486e-01 no
## S_VLDL_L 1.1850732 5.712167e-01 no
## Lac 1.1697298 5.796900e-01 no
## XL_HDL_FC 1.1027574 6.164943e-01 no
## L_HDL_FC 1.1037748 6.174189e-01 no
## XL_HDL_CE_. 1.1821922 6.251279e-01 no
## Ace 1.1487395 6.298153e-01 no
## Alb 1.1770841 6.373462e-01 no
## HDL_C 1.1062258 6.468774e-01 no
## M_HDL_FC 1.1739956 6.484391e-01 no
## M_LDL_TG 1.1061807 6.588079e-01 no
## M_VLDL_CE 1.1756357 6.619134e-01 no
## M_HDL_CE_. 1.1121225 6.689416e-01 no
## bOHBut 1.1485064 6.914752e-01 no
## FAw3.FA 1.1104212 6.994829e-01 no
## LDL_TG 1.1112626 7.099496e-01 no
## HDL2_C 1.1128564 7.139163e-01 no
## L_HDL_TG 1.1647604 7.426727e-01 no
## S_VLDL_FC 1.1650027 7.435322e-01 no
## L_HDL_C_. 1.1717255 7.523522e-01 no
## M_HDL_PL_. 1.1677707 7.558275e-01 no
## Glol 1.3512396 7.751753e-01 no
## His 1.1675715 7.828525e-01 no
## L_HDL_PL 1.1206904 7.876859e-01 no
## Ala 1.1207107 8.112379e-01 no
## DHA 1.1229111 8.236856e-01 no
## ApoA1 1.1232070 8.316672e-01 no
## TotPG 1.1289733 8.662708e-01 no
## L_HDL_L 1.1283010 8.696435e-01 no
## VLDL_C 1.1549815 8.702276e-01 no
## L_HDL_P 1.1287340 8.739765e-01 no
## FAw3 1.1506410 8.781978e-01 no
## IDL_TG 1.1298812 8.952909e-01 no
## XL_VLDL_FC_. 1.1404212 9.076813e-01 no
## L_HDL_C 1.1322897 9.137184e-01 no
## L_VLDL_PL_. 1.1402808 9.496158e-01 no
## XXL_VLDL_FC_. 1.1458515 9.824168e-01 no
## L_HDL_CE 1.1412230 9.888224e-01 no
## [[1]]
## [[1]]$`024MDF.m9oCLq`
##
## [[1]]$`0lNgML.m9oCLq`
##
## [[1]]$`0puWor.m9oCLq`
##
## [[1]]$`0tV55U.m9oCLq`
##
## [[1]]$`0ZrS6h.m9oCLq`
##
## [[1]]$`1fHIdc.m9oCLq`
##
## [[1]]$`1GbArZ.m9oCLq`
##
## [[1]]$`1Ph07B.m9oCLq`
##
## [[1]]$`1t6vRx.m9oCLq`
##
## [[1]]$`230WW0.m9oCLq`
##
## [[1]]$`2JUw80.m9oCLq`
##
## [[1]]$`3GaVRa.m9oCLq`
##
## [[1]]$`3MNLVl.m9oCLq`
##
## [[1]]$`3Q956t.m9oCLq`
##
## [[1]]$`4izNmd.m9oCLq`
##
## [[1]]$`4qbGKG.m9oCLq`
##
## [[1]]$`4V86dY.m9oCLq`
##
## [[1]]$`52XACa.m9oCLq`
##
## [[1]]$`5mmaIe.m9oCLq`
##
## [[1]]$`5tCFbV.m9oCLq`
##
## [[1]]$`7bWiH8.m9oCLq`
##
## [[1]]$`7vxvBj.m9oCLq`
##
## [[1]]$`7YFiAn.m9oCLq`
##
## [[1]]$`8bgjc9.m9oCLq`
##
## [[1]]$`8G9Knn.m9oCLq`
##
## [[1]]$`91Pjqu.m9oCLq`
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## [[1]]$`92WdbN.m9oCLq`
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## [[1]]$gzdreo.m9oCLq
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## [[1]]$MIC3vI.m9oCLq
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## [[1]]$muqBZb.m9oCLq
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## [[1]]$Nv3f2x.m9oCLq
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## [[1]]$O52owj.m9oCLq
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## [[1]]$Oo7HEZ.m9oCLq
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## [[1]]$OtW0rc.m9oCLq
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## [[1]]$P1CEJx.m9oCLq
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## [[1]]$WZoDbF.m9oCLq
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## [[1]]$x4EzD4.m9oCLq
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## [[1]]$xiI00u.m9oCLq
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## [[1]]$XqJLv6.m9oCLq
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## [[1]]$YMPGNM.m9oCLq
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## [[1]]$YpgGoc.m9oCLq
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## [[1]]$YYGssD.m9oCLq
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## [[1]]$z2RiJF.m9oCLq
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## [[1]]$ZFCRbQ.m9oCLq
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## [[1]]$zIAnYa.m9oCLq
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