A Futile Cycle in the Folate usage pathway

J. Enrique Salcedo-Sora

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Copasi 2016, Manchester
12 May 2016

The Folate cycle: a Biochemist perspective

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The Folate cycle: the simple version

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The Folinic acid futile cycle

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The folinic acid futile cycle

  • Drives the total flux of the Folate cycle
  • Sustain a steady folate (“specific”) mass of Folate metabolites
  • Feeds out anabolic mass precursors (NADPH)

Specific versus total mass

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