Time dependent covariate model - Infection vs. No Infection
## Call:
## coxph(formula = Surv(tstart, tstop, tech.failure.or.death) ~
## infection, data = tdata)
##
## n= 13835, number of events= 4556
##
## coef exp(coef) se(coef) z Pr(>|z|)
## infection 0.99547 2.70598 0.03315 30.03 <2e-16 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef) lower .95 upper .95
## infection 2.706 0.3696 2.536 2.888
##
## Concordance= 0.598 (se = 0.003 )
## Rsquare= 0.065 (max possible= 0.996 )
## Likelihood ratio test= 930.1 on 1 df, p=0
## Wald test = 901.9 on 1 df, p=0
## Score (logrank) test = 952.2 on 1 df, p=0
Time dependent covariate model for death - Infection vs. No Infection
## Call:
## coxph(formula = Surv(tstart, tstop, death) ~ infection, data = tdata5)
##
## n= 13835, number of events= 2008
##
## coef exp(coef) se(coef) z Pr(>|z|)
## infection 0.62846 1.87472 0.04833 13 <2e-16 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef) lower .95 upper .95
## infection 1.875 0.5334 1.705 2.061
##
## Concordance= 0.558 (se = 0.005 )
## Rsquare= 0.012 (max possible= 0.911 )
## Likelihood ratio test= 170.1 on 1 df, p=0
## Wald test = 169.1 on 1 df, p=0
## Score (logrank) test = 173.1 on 1 df, p=0
Time to Tech Failure by Early/Late Groups; Time 0 set at 1st Infection
## Call: survfit(formula = Surv(Time2Fu - Time2Infection.1, Event) ~ group,
## data = dat3, start.time = cut.day)
##
## n events median 0.95LCL 0.95UCL
## group=Early (<0.5yr) 1601 748 2.95 2.77 3.26
## group=Late (>0.5yr) 722 326 2.97 2.71 3.53
## yr1 yr2 yr3 yr4 yr5 yr6 yr7 yr8 yr9 yr10
## group=Early (<0.5yr) 1228 753 410 241 150 91 52 24 5 0
## group=Late (>0.5yr) 549 306 184 98 60 33 18 7 0 0
## Call:
## coxph(formula = Surv(Time2Fu - Time2Infection.1, Event) ~ group,
## data = dat3)
##
## n= 2714, number of events= 1390
##
## coef exp(coef) se(coef) z Pr(>|z|)
## groupLate (>0.5yr) 0.32712 1.38697 0.05531 5.914 3.34e-09 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef) lower .95 upper .95
## groupLate (>0.5yr) 1.387 0.721 1.244 1.546
##
## Concordance= 0.561 (se = 0.007 )
## Rsquare= 0.012 (max possible= 0.999 )
## Likelihood ratio test= 33.94 on 1 df, p=5.693e-09
## Wald test = 34.98 on 1 df, p=3.338e-09
## Score (logrank) test = 35.29 on 1 df, p=2.844e-09
Time to Death by Early/Late Groups; Time 0 set at 1st Infection
## Call: survfit(formula = Surv(Time2Fu - Time2Infection.1, Event.Death) ~
## group, data = dat3, start.time = cut.day)
##
## n events median 0.95LCL 0.95UCL
## group=Early (<0.5yr) 1601 328 NA 7.04 NA
## group=Late (>0.5yr) 722 139 NA NA NA
## yr1 yr2 yr3 yr4 yr5 yr6 yr7 yr8 yr9 yr10
## group=Early (<0.5yr) 1228 753 410 241 150 91 52 24 5 0
## group=Late (>0.5yr) 549 306 184 98 60 33 18 7 0 0
## Call:
## coxph(formula = Surv(Time2Fu - Time2Infection.1, Event.Death) ~
## group, data = dat3)
##
## n= 2714, number of events= 582
##
## coef exp(coef) se(coef) z Pr(>|z|)
## groupLate (>0.5yr) 0.18865 1.20761 0.08722 2.163 0.0305 *
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## exp(coef) exp(-coef) lower .95 upper .95
## groupLate (>0.5yr) 1.208 0.8281 1.018 1.433
##
## Concordance= 0.54 (se = 0.011 )
## Rsquare= 0.002 (max possible= 0.954 )
## Likelihood ratio test= 4.58 on 1 df, p=0.03229
## Wald test = 4.68 on 1 df, p=0.03055
## Score (logrank) test = 4.69 on 1 df, p=0.0303