M. Drew LaMar
January 29, 2016
Penzes P, Cahill ME, Jones KA, VanLeeuwen J-E, Woolfrey KM. Dendritic spine pathology in neuropsychiatric disorders. Nat Neurosci. 2011 Mar;14(3):285–93.
“Schizophrenia’s strongest genetic association…arises in part from many structurally diverse alleles of the complement component 4 (C4) genes. We found that these alleles generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C4A… In mice, C4 mediated synapse elimination during postnatal development.”
Sekar A et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Jan 27.
Sekar A et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016 Jan 27.
Definition:
Variables are characteristics that differ among objects of interest.
Definition:
Data are the measurements of one or more variables made on a sample of objects of interest.
Data, essentially, is any measurement of the real world since
Discuss: Would the fraction of birds in a large sample infected with avian flu virus be a discrete or continuous numerical variable?
Frequency distributions of univariate data
Type of data | Graphical method |
---|---|
Categorical | Bar graph |
Numerical | Histogram |
Showing association of bivariate data
Type of data | Graphical method |
---|---|
Two numerical | Scatter plot |
“ | Line plot |
” | Map |
Two categorical | Grouped bar graph |
“ | Mosaic plot |
Mixed | Strip chart |
” | Box plot |
“ | Multiple histograms |
” | Cumulative frequency distributions |