Overview: progress towards the PET targets

How this is counted. Each participant is counted once, at the furthest point they have reached: enrolled (has a SPINAPS record), eligible (Eligibility Checklist says eligible), PET done (PET Scan Information form completed), then PET usable on QC. A PET whose QC form is still empty is shown as QC pending rather than unusable, because no QC decision has been made yet. Targets count usable PETs only, because the protocol replaces participants whose PET cannot be used. The pilot target (Aim 1) is 10 per group; the full sample (Aim 2) is 28 ASD-Impaired, 27 ASD-Intact and 29 TDC (config/targets.csv).

Group	Enrolled	Eligible	PET done	QC pending	PET usable	Withdrawn	Pilot (Aim 1)		Full sample (Aim 2)
Group	Enrolled	Eligible	PET done	QC pending	PET usable	Withdrawn	Pilot target	Pilot met	Full target	Full met	Still needed
ASD-Impaired	22	22	21	0	21	0	10	210%	28	75%	7
ASD-Intact	1	1	1	0	1	0	10	10%	27	4%	26
TDC	19	19	19	9	10	0	10	100%	29	34%	19
Not assigned	7	2	2	2	0	1
TOTAL	49	44	43	11	32	1	30	107%	84	38%	52
Notes. Counts are participants. PET usable = reconstructed image judged usable on QC; QC pending = PET done but the QC form is not filled in yet. Targets count usable PETs only. Not assigned = no group recorded on the Eligibility Checklist (no target).

Recruitment

By month

How this is counted. There is no e-consent project for SPINAPS, so a participant is counted as recruited in the month of their eligibility assessment (elg_doa, Eligibility Checklist), the first study procedure after consent. Participants without an eligibility date are left out of these plots (5 at present).

Where participants came from

How this is counted. The protocol recruits mainly from SPIN-ASD and SPIN-R, and also from TAY, SYNAPSIS, a cannabis and alcohol PET study, CAMH clinics and referrals, and advertising. REDCap records only the first three: a participant is counted under SPIN-ASD or SPIN-R when they are linked to a record there (the IDs on the Shared Data Availability form, checked against the origin project, or the matching SPN40 number; see Data Quality, Origin IDs). Participants in both are shown once, under SPIN-ASD and SPIN-R. TAY is not pulled (no API access), so TAY participants are counted only when the Shared Data form ticks TAY. Not linked covers everyone else: other studies, clinics, advertising, or an origin ID that is missing or wrong. The source of those participants is not recorded in REDCap.

Source	ASD			TDC	Not assigned	Total
Source	ASD-Impaired	ASD-Intact	All ASD	TDC	Not assigned	Total
SPIN-R	9	0	9	12	5	26
SPIN-ASD	6	0	6	6	0	12
SPIN-ASD and SPIN-R	7	1	8	1	0	9
Not linked to SPIN-ASD or SPIN-R	0	0	0	0	2	2

Withdrawals

How this is counted. A participant is withdrawn when the Early Termination/Withdrawal Checklist says they were prematurely withdrawn (term_premature_yn); the reason is the one ticked on that form. This includes participants who never received a group, so they appear under Not assigned.

Reason	Not assigned
Lost to follow-up	1

Participant Flow

Summary of who is in the study, where they came from and whether they completed it, for the SPINAPS paper.

What REDCap can and cannot show. The flow starts at a SPINAPS record, which is created at consent. Who was contacted, who was interested and why people did not consent are recorded only in the screening log, which is not in REDCap, so those boxes of a CONSORT diagram cannot be filled from here.

How each step is counted.

Enrolled: recorded as eligible on the Eligibility Checklist. Not enrolled shows the criteria answered the ineligible way (config/eligibility_criteria.csv), or that the checklist is not filled in.
PET scan done: a PET date is entered or the PET Scan Information form is marked completed.
Withdrawn: the Early Termination/Withdrawal Checklist says the participant was prematurely withdrawn; before or after PET depends on whether the PET scan was done.
Completed: enrolled, PET scan done and not withdrawn. This counts what the participant did, not what has been entered: PET QC and data entry run behind the visits.
Data still in progress (grey box): for completed participants, what is not in REDCap yet: PET QC form, an MRI on the Shared Data Availability form (SPINAPS REDCap has no MRI form of its own), and IQ, MATRICS composite or RMET in SPINAPS or the origin study. These are not dropouts.

Flow

Each column follows the participants who came from one study. When a participant was in both SPIN-ASD and SPIN-R, they are counted under SPIN-R (the later study, and the preferred source on the Shared Data form). Beside each arrow: who dropped out at that point and why, or who is still waiting.

Please note : PET data missing refers to pending QC. The final completed number is calculated based on having all data points completed - from cog scales, PET QC, etc.

ASD in SPINAPS (consented)

n = 23

ASD-Impaired 22 · ASD-Intact 1

From SPIN-R

n = 17

ASD-Impaired 16 · ASD-Intact 1

Enrolled (eligible)

n = 17

ASD-Impaired 16 · ASD-Intact 1

PET scan done

n = 17

ASD-Impaired 16 · ASD-Intact 1

Completed

n = 17

ASD-Impaired 16 · ASD-Intact 1

Data still in progress (not dropouts)

IQ not yet entered: 9

From SPIN-ASD

n = 6

ASD-Impaired 6 · ASD-Intact 0

Enrolled (eligible)

n = 6

ASD-Impaired 6 · ASD-Intact 0

Still waiting for PET: 1

PET scan done

n = 5

ASD-Impaired 5 · ASD-Intact 0

Completed

n = 5

ASD-Impaired 5 · ASD-Intact 0

Data still in progress (not dropouts)

All data in

Controls (TDC) in SPINAPS (consented)

n = 19

From SPIN-R

n = 13

Enrolled (eligible)

n = 13

PET scan done

n = 13

Completed

n = 13

Data still in progress (not dropouts)

PET QC pending: 5

MRI not yet on Shared Data form: 1

IQ not yet entered: 4

MATRICS not yet entered: 1

From SPIN-ASD

n = 6

Enrolled (eligible)

n = 6

PET scan done

n = 6

Completed

n = 6

Data still in progress (not dropouts)

PET QC pending: 4

MRI not yet on Shared Data form: 1

No group recorded (consented)

n = 7

From SPIN-R

n = 7

Not enrolled: 5

• Eligibility Checklist not completed (5)

Enrolled (eligible)

n = 2

PET scan done

n = 2

Completed

n = 2

Data still in progress (not dropouts)

PET QC pending: 2

IQ not yet entered: 2

MATRICS not yet entered: 1

From SPIN-ASD

n = 0

Enrolled (eligible)

n = 0

PET scan done

n = 0

Completed

n = 0

Data still in progress (not dropouts)

All data in

Participants

One row per participant: where they came from, their status, and the data still in progress for anyone scanned.

Participant	Group	Came from	Origin IDs	Status	Data still in progress	Withdrawal reason	Not enrolled because
SPN40_CMH_100104	Not assigned	SPIN-R	SPN31_CMH_100104	Not enrolled		Lost to follow-up	Eligibility Checklist not completed
SPN40_CMH_500010/90076	Not assigned	Not linked to SPIN-ASD or SPIN-R		Not enrolled			Eligibility Checklist not completed
SPN40_CMH_50010/90084	Not assigned	SPIN-R	SPN31_CMH_050010	Not enrolled			Eligibility Checklist not completed
SPN40_CMH_50016/90108	Not assigned	SPIN-R	SPN30_CMH_050016	Not enrolled			Eligibility Checklist not completed
SPN40_CMH_90037	Not assigned	Not linked to SPIN-ASD or SPIN-R		Not enrolled			Eligibility Checklist not completed
SPN40_CMH_100133	ASD-Impaired	SPIN-ASD	SPASD_CMP_0133	Enrolled, awaiting PET
SPN40_CMH_0116	ASD-Impaired	SPIN-ASD	SPASD_CMP_0116	Completed
SPN40_CMH_0118	ASD-Impaired	SPIN-ASD	SPASD_CMP_0118	Completed
SPN40_CMH_0142	ASD-Impaired	SPIN-ASD	SPASD_CMP_0142	Completed
SPN40_CMH_0146	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0146, SPN31_CMH_100146	Completed
SPN40_CMH_100002	ASD-Impaired	SPIN-R	SPN31_CMH_100002	Completed	IQ
SPN40_CMH_100003	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0003, SPN31_CMH_100003	Completed
SPN40_CMH_100006	ASD-Impaired	SPIN-R	SPN31_CMH_100006	Completed	IQ
SPN40_CMH_100020	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0020, SPN31_CMH_100020	Completed
SPN40_CMH_100029	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0029, SPN31_CMH_100029	Completed
SPN40_CMH_100035	ASD-Impaired	SPIN-R	SPN31_CMH_100035	Completed	IQ
SPN40_CMH_100036	ASD-Impaired	SPIN-R	SPN31_CMH_100036	Completed	IQ
SPN40_CMH_100047	ASD-Impaired	SPIN-R	SPN31_CMH_100047	Completed	IQ
SPN40_CMH_100056	ASD-Impaired	SPIN-R	SPN31_CMH_100056	Completed	IQ
SPN40_CMH_100060	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0060, SPN31_CMH_100060	Completed
SPN40_CMH_100068	ASD-Impaired	SPIN-R	SPN31_CMH_100068	Completed	IQ
SPN40_CMH_100070	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0070, SPN31_CMH_100070	Completed
SPN40_CMH_100091	ASD-Impaired	SPIN-R	SPN31_CMH_100091	Completed	IQ
SPN40_CMH_100113	ASD-Impaired	SPIN-ASD	SPASD_CMP_0113	Completed
SPN40_CMH_100115	ASD-Impaired	SPIN-ASD	SPASD_CMP_0115	Completed
SPN40_CMH_100125	ASD-Impaired	SPIN-ASD and SPIN-R	SPASD_CMP_0125, SPN31_CMH_100125	Completed
SPN40_CMH_60001	ASD-Impaired	SPIN-R	SPN31_CMH_060001	Completed	IQ
SPN40_CMH_100012	ASD-Intact	SPIN-ASD and SPIN-R	SPASD_CMP_0012, SPN31_CMH_100012	Completed
SPN40_CMH_0122	TDC	SPIN-ASD	SPASD_CMP_0122	Completed
SPN40_CMH_0135	TDC	SPIN-ASD	SPASD_CMP_0135	Completed
SPN40_CMH_0156/90102	TDC	SPIN-ASD	SPASD_CMP_0156	Completed	PET QC, MRI
SPN40_CMH_0157/90079	TDC	SPIN-ASD	SPASD_CMP_0157	Completed	PET QC
SPN40_CMH_0158/90080	TDC	SPIN-ASD	SPASD_CMP_0158	Completed	PET QC
SPN40_CMH_0159/90086	TDC	SPIN-ASD	SPASD_CMP_0159	Completed	PET QC
SPN40_CMH_100094	TDC	SPIN-ASD and SPIN-R	SPASD_CMP_0094, SPN31_CMH_100094	Completed
SPN40_CMH_100117	TDC	SPIN-R	SPN31_CMH_100117	Completed	IQ
SPN40_CMH_100119	TDC	SPIN-R	SPN31_CMH_100119	Completed	IQ
SPN40_CMH_100132	TDC	SPIN-R	SPN30_CMH_010158	Completed	IQ
SPN40_CMH_50001	TDC	SPIN-R	SPN30_CMH_050001	Completed
SPN40_CMH_50002/90073	TDC	SPIN-R	SPN30_CMH_050002	Completed	PET QC
SPN40_CMH_50004	TDC	SPIN-R	SPN30_CMH_050004	Completed
SPN40_CMH_50005	TDC	SPIN-R	SPN31_CMH_050005	Completed
SPN40_CMH_50006/90087	TDC	SPIN-R	SPN31_CMH_050006	Completed
SPN40_CMH_50007/90075	TDC	SPIN-R	SPN31_CMH_050007	Completed	PET QC
SPN40_CMH_50008/90081	TDC	SPIN-R	SPN31_CMH_050008	Completed	PET QC
SPN40_CMH_50013/90091	TDC	SPIN-R	SPN30_CMH_050013	Completed	PET QC
SPN40_CMH_50017/90105	TDC	SPIN-R	SPN30_CMH_050017	Completed	PET QC, MRI, IQ, MATRICS
SPN40_CMH_60003	Not assigned	SPIN-R	SPN31_CMH_060003	Completed	PET QC, IQ
SPN40_CMH_60004	Not assigned	SPIN-R	SPN31_CMH_060004	Completed	PET QC, IQ, MATRICS

Descriptive Statistics

SPINAPS REDCap

What is shown. Everyone with a SPINAPS record, by group, using the SPINAPS Demographics and Height/Weight/Vitals forms. Gender is shown as recorded (check all that apply; none of the current participants ticked more than one). Mother’s education has two fields on the form and either is used. Handedness and parental education are only filled in for a few participants in SPINAPS; the From origin study tab adds them from the study each participant came from. Values entered as REDCap missing-data codes (e.g. ASKU) or outside their valid range count as missing. Current SSRI and antipsychotic use are added because the protocol matches the groups on them (3.2.1, with age, sex, gender and handedness); they come from the psychotropic medication form and are missing when that form is not completed (see Medications).

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=7)	Overall (N=49)
Age at study entry (years)
Mean (SD)	24 (± 4.7)	28 (± NA)	25 (± 5.3)	21 (± 4.2)	25 (± 5.0)
Median [Min, Max]	24 [17, 35]	28 [28, 28]	23 [18, 33]	21 [16, 25]	23 [16, 35]
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Sex assigned at birth
Female	12 (55 %)	0 (0 %)	9 (47 %)	2 (29 %)	23 (47 %)
Male	10 (45 %)	1 (100 %)	10 (53 %)	2 (29 %)	23 (47 %)
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Gender identity
Gender fluid	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
Man	9 (41 %)	0 (0 %)	10 (53 %)	2 (29 %)	21 (43 %)
Non-binary	1 (5 %)	0 (0 %)	1 (5 %)	0 (0 %)	2 (4 %)
Not listed	1 (5 %)	0 (0 %)	0 (0 %)	1 (14 %)	2 (4 %)
Trans woman	0 (0 %)	1 (100 %)	0 (0 %)	0 (0 %)	1 (2 %)
Woman	9 (41 %)	0 (0 %)	8 (42 %)	1 (14 %)	18 (37 %)
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Handedness
Left	0 (0 %)	0 (0 %)	0 (0 %)	1 (14 %)	1 (2 %)
Right	0 (0 %)	0 (0 %)	4 (21 %)	2 (29 %)	6 (12 %)
Missing	22 (100%)	1 (100%)	15 (78.9%)	4 (57.1%)	42 (85.7%)
Education (years)
Mean (SD)	14 (± 2.0)	12 (± NA)	16 (± 2.1)	12 (± 2.6)	15 (± 2.4)
Median [Min, Max]	14 [10, 17]	12 [12, 12]	16 [12, 20]	12 [10, 16]	15 [10, 20]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	3 (42.9%)	5 (10.2%)
Mother's education (years)
Mean (SD)	NA (± NA)	NA (± NA)	14 (± 2.3)	19 (± 1.0)	16 (± 3.2)
Median [Min, Max]	NA [NA, NA]	NA [NA, NA]	14 [12, 16]	19 [18, 20]	16 [12, 20]
Missing	22 (100%)	1 (100%)	15 (78.9%)	4 (57.1%)	42 (85.7%)
Father's education (years)
Mean (SD)	NA (± NA)	NA (± NA)	15 (± 2.0)	18 (± 2.0)	16 (± 2.4)
Median [Min, Max]	NA [NA, NA]	NA [NA, NA]	16 [12, 16]	18 [16, 20]	16 [12, 20]
Missing	22 (100%)	1 (100%)	15 (78.9%)	4 (57.1%)	42 (85.7%)
BMI (kg/m²)
Mean (SD)	27 (± 7.1)	27 (± NA)	24 (± 3.4)	29 (± 11)	26 (± 6.0)
Median [Min, Max]	28 [15, 43]	27 [27, 27]	24 [19, 31]	29 [21, 36]	25 [15, 43]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	5 (71.4%)	7 (14.3%)
Current SSRI
Yes	7 (32 %)	0 (0 %)	1 (5 %)	2 (29 %)	10 (20 %)
No	15 (68 %)	1 (100 %)	18 (95 %)	1 (14 %)	35 (71 %)
Missing	0 (0%)	0 (0%)	0 (0%)	4 (57.1%)	4 (8.2%)
Current antipsychotic
Yes	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
No	20 (91 %)	1 (100 %)	19 (100 %)	3 (43 %)	43 (88 %)
Missing	0 (0%)	0 (0%)	0 (0%)	4 (57.1%)	4 (8.2%)

From origin study

What is shown. The SPINAPS demographics above, with the measures that come from the referring study (the assessment closest to the PET; see Data Sharing): IQ, handedness from the Edinburgh Handedness Inventory (laterality quotient from −1, fully left, to +1, fully right; ≥ 0.5 counted as right, ≤ −0.5 as left, in between as mixed) and parental education.

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=7)	Overall (N=49)
Age at study entry (years)
Mean (SD)	24 (± 4.7)	28 (± NA)	25 (± 5.3)	21 (± 4.2)	25 (± 5.0)
Median [Min, Max]	24 [17, 35]	28 [28, 28]	23 [18, 33]	21 [16, 25]	23 [16, 35]
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Sex assigned at birth
Female	12 (55 %)	0 (0 %)	9 (47 %)	2 (29 %)	23 (47 %)
Male	10 (45 %)	1 (100 %)	10 (53 %)	2 (29 %)	23 (47 %)
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Gender identity
Gender fluid	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
Man	9 (41 %)	0 (0 %)	10 (53 %)	2 (29 %)	21 (43 %)
Non-binary	1 (5 %)	0 (0 %)	1 (5 %)	0 (0 %)	2 (4 %)
Not listed	1 (5 %)	0 (0 %)	0 (0 %)	1 (14 %)	2 (4 %)
Trans woman	0 (0 %)	1 (100 %)	0 (0 %)	0 (0 %)	1 (2 %)
Woman	9 (41 %)	0 (0 %)	8 (42 %)	1 (14 %)	18 (37 %)
Missing	0 (0%)	0 (0%)	0 (0%)	3 (42.9%)	3 (6.1%)
Education (years)
Mean (SD)	14 (± 2.0)	12 (± NA)	16 (± 2.1)	12 (± 2.6)	15 (± 2.4)
Median [Min, Max]	14 [10, 17]	12 [12, 12]	16 [12, 20]	12 [10, 16]	15 [10, 20]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	3 (42.9%)	5 (10.2%)
Full-scale IQ
Mean (SD)	120 (± 15)	110 (± NA)	120 (± 14)	140 (± NA)	120 (± 14)
Median [Min, Max]	120 [89, 140]	110 [110, 110]	120 [84, 140]	140 [140, 140]	120 [84, 140]
Missing	9 (40.9%)	0 (0%)	4 (21.1%)	6 (85.7%)	19 (38.8%)
Handedness (Edinburgh)
Left	1 (5 %)	0 (0 %)	2 (11 %)	0 (0 %)	3 (6 %)
Mixed	4 (18 %)	0 (0 %)	2 (11 %)	1 (14 %)	7 (14 %)
Right	9 (41 %)	1 (100 %)	12 (63 %)	2 (29 %)	24 (49 %)
Missing	8 (36.4%)	0 (0%)	3 (15.8%)	4 (57.1%)	15 (30.6%)
Laterality quotient
Mean (SD)	0.48 (± 0.49)	0.87 (± NA)	0.55 (± 0.55)	0.23 (± 0.46)	0.51 (± 0.51)
Median [Min, Max]	0.69 [-0.67, 1.0]	0.87 [0.87, 0.87]	0.70 [-0.87, 1.0]	0.50 [-0.30, 0.50]	0.64 [-0.87, 1.0]
Missing	8 (36.4%)	0 (0%)	3 (15.8%)	4 (57.1%)	15 (30.6%)
Mother's education (years)
Mean (SD)	16 (± 2.2)	12 (± NA)	15 (± 2.6)	16 (± 2.5)	16 (± 2.4)
Median [Min, Max]	16 [12, 20]	12 [12, 12]	16 [11, 20]	16 [12, 19]	16 [11, 20]
Missing	0 (0%)	0 (0%)	0 (0%)	2 (28.6%)	2 (4.1%)
Father's education (years)
Mean (SD)	16 (± 2.2)	11 (± NA)	16 (± 2.4)	16 (± 0.89)	16 (± 2.3)
Median [Min, Max]	16 [12, 20]	11 [11, 11]	16 [12, 20]	16 [16, 18]	16 [11, 20]
Missing	0 (0%)	0 (0%)	0 (0%)	2 (28.6%)	2 (4.1%)
BMI (kg/m²)
Mean (SD)	27 (± 7.1)	27 (± NA)	24 (± 3.4)	29 (± 11)	26 (± 6.0)
Median [Min, Max]	28 [15, 43]	27 [27, 27]	24 [19, 31]	29 [21, 36]	25 [15, 43]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	5 (71.4%)	7 (14.3%)
Current SSRI
Yes	7 (32 %)	0 (0 %)	1 (5 %)	2 (29 %)	10 (20 %)
No	15 (68 %)	1 (100 %)	18 (95 %)	1 (14 %)	35 (71 %)
Missing	0 (0%)	0 (0%)	0 (0%)	4 (57.1%)	4 (8.2%)
Current antipsychotic
Yes	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
No	20 (91 %)	1 (100 %)	19 (100 %)	3 (43 %)	43 (88 %)
Missing	0 (0%)	0 (0%)	0 (0%)	4 (57.1%)	4 (8.2%)

Distributions

What is shown. The spread of the main descriptive variables by group, for everyone with a SPINAPS record (one bin = one year of age or education; 5 IQ points). Groups are overlaid, so where they overlap the colours mix. IQ comes from the origin studies (see Data Sharing), because no IQ has been entered in SPINAPS REDCap yet.

Age

Sex

Gender

Education

IQ (origin study)

Data Sharing

Most SPINAPS participants took part in SPIN-ASD or SPIN-R first, and the protocol reuses their assessments and MRI instead of repeating them. This section shows where each participant’s data came from, using the Shared Data Availability form and the origin studies’ REDCap projects.

Sources

How this is counted. The studies ticked on the Shared Data Availability form, separately for clinical data and MRI. A participant who was in SPIN-ASD and then SPIN-R can have both ticked.

Clinical data shared from	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
None recorded	0	0	2	4	6
SPIN-ASD	7	0	5	0	12
SPIN-ASD + SPIN-R	5	1	1	0	7
SPIN-R	10	0	11	3	24

MRI shared from	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
None recorded	0	0	2	4	6
SPIN-ASD	7	0	6	0	13
SPIN-R	15	1	11	3	30

Shared assessments

How this is read. One row per participant (sorted by group), one column per assessment on the form’s checklist. Green = ticked as shared from the referring study. Assessments not ticked were either done in SPINAPS or are not available.

MRI

Why it matters. SPINAPS does not repeat the MRI when a good-quality one exists from the referring study. Multi-shell diffusion is needed for the NODDI analyses in the exploratory aim, so it is counted separately.

Shared MRI quality	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
Good	7	0	4	0	11
OK	13	1	6	2	22
Poor	0	0	0	1	1
Not recorded	2	0	9	4	15

Multi-shell DWI available	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
No	22	1	19	6	48
Yes	0	0	0	1	1

Age of shared assessments

How this is chosen. For the From origin study tabs in this report, each participant’s score on each instrument comes from their linked origin visit (SPIN-ASD, or any SPIN-R visit) closest in time to their SPINAPS PET, or to their eligibility assessment if there is no PET yet. The protocol (3.4, version 5) reuses most assessments only if they are at most 6 months old, so the dashed line marks 6 months. IQ, ADOS-2, AQ, handedness and parental education (SES) are reused whatever their age; they are marked (no limit) and have no within / older counts. Within limit counts assessments up to 6 months either side of the PET. Hover over a point for the origin record and visit.

Instrument	Participants	From SPIN-ASD	From SPIN-R	Median months before PET	Protocol limit	Within limit	Older than limit	No date
ABAS-III	45	12	33	3.6	6 months	27	16	2
ADOS-2 (no limit)	15	14	1	16.2	None			0
AQ (no limit)	47	12	35	3.5	None			3
BPRS	25	6	19	5.9	6 months	12	12	1
Birchwood SFS	47	12	35	5.0	6 months	27	17	3
ER-40	47	12	35	3.5	6 months	28	16	3
Edinburgh Handedness (no limit)	34	21	13	3.6	None			1
MATRICS	44	12	32	3.8	6 months	26	16	2
Parental education (no limit)	47	12	35	5.1	None			3
RMET	47	12	35	3.5	6 months	28	16	3
TASIT-R	46	12	34	3.6	6 months	27	16	3
WASI-II (no limit)	30	21	9	7.2	None			1

Assessment Completion

SPINAPS REDCap

How this is read. One row per participant, one column per form given at the SPINAPS assessment event, in REDCap’s order, read from the REDCap project itself (no hand-kept form list). Each cell is the form’s “Was this form completed?” answer. Green = completed, gold = partly completed, red = recorded as not completed, grey = nothing entered. Forms without that question (AQ, ABAS-III) use REDCap’s own form status: “Incomplete” is gold when the form has answers and grey when it was never opened. Dates, rater, REDCap ID, notes, mode of administration, validity questions and calculated fields don’t count as answers, and an unticked checkbox doesn’t either. The two ABAS-III forms (summary scores and questionnaire) share one column. Logs (withdrawal checklist, progress notes, adverse events, change log) are left out. Hover over a cell for the recorded answer and, for forms marked not completed, the reason. Not shown: SCID-5. The REDCap API returns no fields from this form, which usually means the API user has no export rights on it.

ASD-Impaired

ASD-Intact

TDC

Not assigned

From origin study

How this is read. Whether a score for each instrument exists in the participant’s linked SPIN-ASD or SPIN-R records (see Data Sharing), and how old it is at the SPINAPS PET. Green = reusable under the protocol (3.4): within 6 months of the PET, or an instrument reused whatever its age (IQ, ADOS-2, AQ, handedness, parental education); gold = older than 6 months, or no assessment date; grey = no origin score. Each row is labelled with the SPN40 ID and the origin record(s) it is linked to (SPIN-ASD SPASD_..., SPIN-R SPN3x_...). Hover over a cell for the study, origin ID, visit and assessment date the score came from, or, for a grey cell, which linked records were searched. This is what could be uploaded to SPINAPS now, and what would need re-assessing.

ASD-Impaired

ASD-Intact

TDC

Not assigned

Group Assignment Check

What is checked. Whether each ASD participant’s recorded subgroup (Eligibility Checklist, elg_group) matches the protocol rule (3.3.2, version 5). ASD-Impaired means at least one of: MATRICS composite or RMET total at least 1 SD below the mean of the SPIN-ASD and SPINS typically developing controls aged 16-35, or IQ < 90. Otherwise ASD-Intact. The rule is applied to every participant, including those grouped before the protocol changed.

Why only cognition. Earlier, the rule also used the Birchwood SFS and ABAS-III; the protocol dropped them because too many participants were impaired on SFS. The REDCap Eligibility Checklist (elg_impaired, elg_comp_assess) still lists SFS and ABAS-III.

The cut-offs are the values the PI computed from those controls at the start of the study (config/group_cutoffs.csv). They are not recomputed here, because the control data have changed since.

Measure	Impaired if
Full-scale IQ (WASI-II / WAIS-IV)	< 90
MATRICS composite (T-score)	≤ 41.61391
RMET total	≤ 24.84015

SPINAPS REDCap

No IQ, MATRICS or RMET scores have been entered in SPINAPS REDCap yet.

From origin study

Recorded group	Group by the protocol rule
Recorded group	ASD-Impaired	ASD-Intact	ASD-Intact (incomplete scores)
ASD-Impaired	10	7	5
ASD-Intact	1	0	0

Participant	Recorded group	IQ	MATRICS (T)	RMET	Below cut-off	Group by rule	Agrees
SPN40_CMH_0118	ASD-Impaired	123	46	29		ASD-Intact	No
SPN40_CMH_0146	ASD-Impaired	133	65	28		ASD-Intact	No
SPN40_CMH_100002	ASD-Impaired		54	28		ASD-Intact (incomplete scores)	No
SPN40_CMH_100003	ASD-Impaired	137	62	29		ASD-Intact	No
SPN40_CMH_100047	ASD-Impaired		51	31		ASD-Intact (incomplete scores)	No
SPN40_CMH_100056	ASD-Impaired		47	27		ASD-Intact (incomplete scores)	No
SPN40_CMH_100060	ASD-Impaired	117	55	26		ASD-Intact	No
SPN40_CMH_100068	ASD-Impaired		49	32		ASD-Intact (incomplete scores)	No
SPN40_CMH_100070	ASD-Impaired	121	47	30		ASD-Intact	No
SPN40_CMH_100125	ASD-Impaired	127	62	29		ASD-Intact	No
SPN40_CMH_100133	ASD-Impaired	120	52	28		ASD-Intact	No
SPN40_CMH_60001	ASD-Impaired		55	26		ASD-Intact (incomplete scores)	No
SPN40_CMH_100012	ASD-Intact	113	49	23	RMET	ASD-Impaired	No
SPN40_CMH_0116	ASD-Impaired	89	49	27	IQ < 90	ASD-Impaired	Yes
SPN40_CMH_0142	ASD-Impaired	117	9	34	MATRICS	ASD-Impaired	Yes
SPN40_CMH_100006	ASD-Impaired		41	28	MATRICS	ASD-Impaired	Yes
SPN40_CMH_100020	ASD-Impaired	105	41	33	MATRICS	ASD-Impaired	Yes
SPN40_CMH_100029	ASD-Impaired	109	45	17	RMET	ASD-Impaired	Yes
SPN40_CMH_100035	ASD-Impaired		38	24	MATRICS, RMET	ASD-Impaired	Yes
SPN40_CMH_100036	ASD-Impaired		41	29	MATRICS	ASD-Impaired	Yes
SPN40_CMH_100091	ASD-Impaired		54	20	RMET	ASD-Impaired	Yes
SPN40_CMH_100113	ASD-Impaired	137	35	27	MATRICS	ASD-Impaired	Yes
SPN40_CMH_100115	ASD-Impaired	94	46	24	RMET	ASD-Impaired	Yes
Cut-offs: IQ < 90; MATRICS ≤ 41.6; RMET ≤ 24.8. Incomplete scores: no criterion is met but at least one score is missing, so impairment cannot be ruled out.

Structured Clinical Interview for DSM Disorders (SCID)

Bars show the number of participants in each group with each SCID-5 diagnosis. A participant with several diagnoses is counted once for each.

Current: meets symptomatic criteria within the time window the SCID-5 specifies for the disorder (the past month for most; up to the past 2 years for some).
Lifetime: has ever met diagnostic criteria (lifetime prevalence rated Threshold; in SPIN-ASD, any disorder recorded, since its form asks only for disorders meeting threshold criteria).
Past only: lifetime but not current. The hover says whether the current rating was absent or not entered, and whether the participant has another current diagnosis.

No current / lifetime diagnosis collects everyone with a SCID but no diagnosis meeting that tab’s definition; the hover gives the reason (the first that applies): no clinical disorder on the SCID; past disorder, no longer current; lifetime disorder, current rating not entered; below threshold only (subthreshold, absent or inadequate information); disorder selected, ratings not entered; disorder said to be present, but none selected. Gaps in data entry are also listed under Data Quality.

Known exceptions. In the SPINAPS / SPIN-R layout, disorders without a lifetime rating (e.g. premenstrual dysphoric, sleep-wake and somatic disorders, adult ADHD) use their current rating for both, so they never appear as Past only. In SPIN-ASD, Unspecified feeding or eating disorder has no current rating, so it is always Past only.

Rule	SPINAPS / SPIN-R layout	SPIN-ASD layout
Any disorder	`scid5_disorder_yn`: 1 Yes, 0 No	`scid5_dis_yn`: 1 Yes, 2 No
Which disorder	category `scid5_disorder_cat___1-12`; dropdowns (categories 1-3) or checkboxes (4-11); free text (12)	up to 10 slots: category `scid5_dis<k>`, disorder `scid5_dis<k>_cat_<category>`, chained by `scid5_cont<k>`
Lifetime	`scid5_cat<c>_<code>_lp` = 3 Threshold (`_pm` when there is no `_lp`)	any disorder recorded
Current	`scid5_cat<c>_<code>_pm` = 3 (3.1-3.4 for bipolar episodes); asked only when `_lp` = 3	any `scid5_dis<k>_past_1m/3m/6m/12m/2y` = 3

From origin study: the SCID closest in time to the participant’s SPINAPS PET among their linked SPIN-ASD and SPIN-R visits, decoded with that study’s score sheet. The protocol reuses the SCID history when it is older than 6 months but re-assesses current status, so Current from an old SCID may be out of date. Decoding is the same as in the SPIN-R dashboard (config/scid_codes_spinr.csv, config/scid_codes_spasd.csv).

SPINAPS REDCap

Current

The SCID-5 form is not exported by the REDCap API (no fields from it are returned, which usually means the API user has no export rights on it).

Lifetime

The SCID-5 form is not exported by the REDCap API (no fields from it are returned, which usually means the API user has no export rights on it).

Past only

The SCID-5 form is not exported by the REDCap API (no fields from it are returned, which usually means the API user has no export rights on it).

From origin study

Current

Lifetime

Past only

Clinical Scores

From origin study

PHQ-9 and GAD-7

Self-reported depression (PHQ-9, 0-27) and anxiety (GAD-7, 0-21) over the past two weeks. 5, 10 and 15 mark mild, moderate and (moderately) severe on both. These are SPINAPS-only questionnaires, so there is no origin tab content.

SPINAPS REDCap

Adaptive behaviour composites (standard scores, mean 100, SD 15): general adaptive composite (GAC) and the conceptual, social and practical domains. ABAS-III is no longer an ASD-Impaired criterion (protocol version 5).

SPINAPS REDCap

No scores entered in SPINAPS REDCap yet.

From origin study

PET Session

What is shown. Participants whose PET Scan Information form is completed, by group: injected dose and mass, the arm used for the arterial line, samples collected, and whether the participant had side effects or complications from the arterial line or the scan. Technician notes are from the PET QC form (notes recorded for the scan or the blood draw). These are SPINAPS procedures, so there is no origin-study tab.

Specific activity (at synthesis and at injection) is not shown: the REDCap fields have no units and the values recorded differ by orders of magnitude, which suggests more than one unit is in use (see Data Quality). Dose and mass values outside their valid range (see Data Quality, Values) are left out and listed there.

	ASD-Impaired (N=21)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=2)	Overall (N=43)
Injected dose (mCi)
Mean (SD)	5.1 (± 0.31)	5.1 (± NA)	5.1 (± 0.24)	NA (± NA)	5.1 (± 0.28)
Median [Min, Max]	5.2 [4.3, 5.6]	5.1 [5.1, 5.1]	5.1 [4.8, 5.6]	NA [NA, NA]	5.1 [4.3, 5.6]
Missing	0 (0%)	0 (0%)	8 (42.1%)	2 (100%)	10 (23.3%)
Injected mass (µg)
Mean (SD)	0.50 (± 0.34)	0.84 (± NA)	0.35 (± 0.086)	NA (± NA)	0.47 (± 0.30)
Median [Min, Max]	0.38 [0.14, 1.6]	0.84 [0.84, 0.84]	0.36 [0.23, 0.51]	NA [NA, NA]	0.38 [0.14, 1.6]
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)
Arterial line arm
Left	13 (62 %)	1 (100 %)	15 (79 %)	0 (0 %)	29 (67 %)
Right	8 (38 %)	0 (0 %)	2 (11 %)	2 (100 %)	12 (28 %)
Missing	0 (0%)	0 (0%)	2 (10.5%)	0 (0%)	2 (4.7%)
Arterial blood samples collected
Yes	21 (100 %)	1 (100 %)	19 (100 %)	2 (100 %)	43 (100 %)
No	0 (0 %)	0 (0 %)	0 (0 %)	0 (0 %)	0 (0 %)
Genetic blood sample collected
Yes	21 (100 %)	1 (100 %)	18 (95 %)	2 (100 %)	42 (98 %)
No	0 (0 %)	0 (0 %)	1 (5 %)	0 (0 %)	1 (2 %)
Side effects or complications
Yes	5 (24 %)	0 (0 %)	1 (5 %)	0 (0 %)	6 (14 %)
No	16 (76 %)	1 (100 %)	18 (95 %)	2 (100 %)	37 (86 %)
Technician notes: scan
Yes	18 (86 %)	1 (100 %)	7 (37 %)	0 (0 %)	26 (60 %)
No	3 (14 %)	0 (0 %)	3 (16 %)	0 (0 %)	6 (14 %)
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)
Technician notes: blood draw
Yes	9 (43 %)	1 (100 %)	2 (11 %)	0 (0 %)	12 (28 %)
No	12 (57 %)	0 (0 %)	8 (42 %)	0 (0 %)	20 (47 %)
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)

Safety

Adverse events

What is shown. Every adverse event recorded on the Adverse Events log, one row per event. 4 participants have at least one event recorded; 37 are recorded as having none.

Participant	Group	Event	Onset	Severity	Related to study	SAE	Outcome
SPN40_CMH_0142	ASD-Impaired	Pain at the arterial line insertion	2024-04-23	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100003	ASD-Impaired	pressure point pain	2023-02-09	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100035	ASD-Impaired	Pain at arterial and venous injection sites	2023-08-17	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100115	ASD-Impaired	sensitivity to local anesthesia and/or latex gloves	2022-11-17	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100115	ASD-Impaired	Client refused aftercare guidlines and experiences tingling due to excessive use of wrist	2022-11-18	Mild	Probably	No	Resolved without sequelae

Urine toxicology

What is shown. The urine drug screen taken on the PET day. Positive results list the drugs recorded.

Urine drug screen	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
Negative	18	1	15	0	34
Positive	1	0	3	2	6

Participant	Group	Positive for
SPN40_CMH_0142	ASD-Impaired	Only positive for drugs on conmed: Fluoxetine
SPN40_CMH_50006/90087	TDC	Diphenhydramine
SPN40_CMH_50013/90091	TDC	Certirzine (antihistamine, not on conmed)
SPN40_CMH_60003	Not assigned	All negative other than the known prescribed medication. This information is recorded on conmed.
SPN40_CMH_60004	Not assigned	Sertaline
SPN40_CMH_100094	TDC	Amphetamine, ephedrine, metformine, pantroprazole, Quetiapine, methylphenidate, venflaxine, hydromorphone

Medications

What is shown. Current psychotropic medications from the SPINAPS Concomitant Medication Record (Psychotropic), for participants whose form is completed. The protocol re-assesses medications in SPINAPS even when they were recorded in the referring study, so there is no origin-study tab. Medication names are free text; config/med_classes.csv maps each name (including the misspellings found) to a generic name and class. Entries with a discontinuation date or marked as not continuing are left out. SSRI and antipsychotic use are matching variables in the protocol.

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=3)	Overall (N=45)
Any psychotropic
Yes	11 (50 %)	0 (0 %)	1 (5 %)	2 (67 %)	14 (31 %)
No	11 (50 %)	1 (100 %)	18 (95 %)	1 (33 %)	31 (69 %)
SSRI
Yes	7 (32 %)	0 (0 %)	1 (5 %)	2 (67 %)	10 (22 %)
No	15 (68 %)	1 (100 %)	18 (95 %)	1 (33 %)	35 (78 %)
SNRI
Yes	1 (5 %)	0 (0 %)	0 (0 %)	0 (0 %)	1 (2 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	3 (100 %)	44 (98 %)
Other antidepressant
Yes	4 (18 %)	0 (0 %)	0 (0 %)	0 (0 %)	4 (9 %)
No	18 (82 %)	1 (100 %)	19 (100 %)	3 (100 %)	41 (91 %)
Antipsychotic
Yes	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
No	20 (91 %)	1 (100 %)	19 (100 %)	3 (100 %)	43 (96 %)
Stimulant
Yes	7 (32 %)	0 (0 %)	0 (0 %)	1 (33 %)	8 (18 %)
No	15 (68 %)	1 (100 %)	19 (100 %)	2 (67 %)	37 (82 %)
Non-stimulant ADHD
Yes	1 (5 %)	0 (0 %)	0 (0 %)	1 (33 %)	2 (4 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	2 (67 %)	43 (96 %)
Sleep
Yes	1 (5 %)	0 (0 %)	0 (0 %)	0 (0 %)	1 (2 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	3 (100 %)	44 (98 %)

Data Quality

Things to correct or confirm in REDCap, collected from every part of this report. Nothing here is changed in REDCap; values outside their valid range are left out of the tables and plots above, and typed IDs are corrected only for linking. The table counts the issues of each check (green = none); the tabs list them.

Check	Issues	Participants
Origin IDs
Typed IDs to correct on the Shared Data form	18	13
Candidate records not used	2	2
Date of birth or sex differs from the origin record	5	3
Participants with no linked origin record	2	2
Shared Data form
Ticked as shared, not found in origin records	21	9
Dates and PET QC
Impossible dates	5	4
PET QC not done 30+ days after the scan	11	11
Values
Values outside their range, not a number or a missing-data code	4	4
Scores of 0 treated as not administered	0	0
Specific activity on a different scale	9	9
Totals from forms not marked completed	0	0
REDCap forms
Marked completed, but no data entered	0	0
Data entered, but not marked completed	0	0
Marked not completed, but has data	0	0
Marked not completed, no reason given	0	0
Reason "Other" with no explanation	0	0
Eligibility
No group or eligibility recorded	7	7
Recorded ASD subgroup differs from the protocol rule	13	13
Enrolled outside age 16-35	0	0
Enrolled with IQ < 70	0	0
TDC with a diagnosis or psychotropic medication	4	3
SCID
SCID data entry gaps	1	1
REDCap setup
Forms not exported by the API	1
Medication names not classified	0	0

Origin IDs

Typed IDs to correct. IDs on the Shared Data Availability form that are not exactly an origin record ID. Most were corrected automatically for linking (the SOASD typo, CMH for CMP in SPIN-ASD, hyphens, a trailing . or /); some match no record. Please correct them on the form so the links do not depend on these fixes.

Participant	Study	Field	Typed ID	Record used	Issue
SPN40_CMH_0116	SPIN-ASD	MRI participant ID	SOASD_CMP_0116	SPASD_CMP_0116	Corrected automatically; please fix in REDCap
SPN40_CMH_0116	SPIN-ASD	Clinical participant ID	SOASD_CMP_0116	SPASD_CMP_0116	Corrected automatically; please fix in REDCap
SPN40_CMH_0135	SPIN-ASD	MRI participant ID	SPASD_CMH_0135	SPASD_CMP_0135	Corrected automatically; please fix in REDCap
SPN40_CMH_0135	SPIN-ASD	Clinical participant ID	SPASD_CMH_0135	SPASD_CMP_0135	Corrected automatically; please fix in REDCap
SPN40_CMH_0142	SPIN-ASD	MRI participant ID	SPASD_CMP_0142.	SPASD_CMP_0142	Corrected automatically; please fix in REDCap
SPN40_CMH_0142	SPIN-ASD	Clinical participant ID	SPASD_CMP_0142.	SPASD_CMP_0142	Corrected automatically; please fix in REDCap
SPN40_CMH_0158/90080	SPIN-ASD	MRI participant ID	SPASD_CMP_0158/	SPASD_CMP_0158	Corrected automatically; please fix in REDCap
SPN40_CMH_0159/90086	SPIN-ASD	MRI participant ID	SPASD_CMP_0159/ SYNAPSIS_CMH_0086	SPASD_CMP_0159	Corrected automatically; please fix in REDCap
SPN40_CMH_50002/90073	SPIN-R	MRI participant ID	SPN31_CMH_050002	SPN30_CMH_050002	Corrected automatically; please fix in REDCap
SPN40_CMH_60004	SPIN-R	MRI participant ID	SPN40_CMH_60004	none	Matches no record
SPN40_CMH_100003	SPIN-ASD	Clinical participant ID	SPASD-CMP-0003	SPASD_CMP_0003	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-ASD	Clinical participant ID	SPASD-CMH-0020	SPASD_CMP_0020	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-R	MRI participant ID	SPN31-CMH-100020	SPN31_CMH_100020	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-R	Clinical participant ID	SPN31-CMH-100020	SPN31_CMH_100020	Corrected automatically; please fix in REDCap
SPN40_CMH_100029	SPIN-R	Clinical participant ID	SPN31_CMH_10029	none	Matches no record
SPN40_CMH_100060	SPIN-R	Clinical participant ID	SPN31-CMH-100060	SPN31_CMH_100060	Corrected automatically; please fix in REDCap
SPN40_CMH_100091	SPIN-R	MRI participant ID	SPN31-CMH-100091	SPN31_CMH_100091	Corrected automatically; please fix in REDCap
SPN40_CMH_100104	SPIN-R	Clinical participant ID	SPN40_CMH_100104	none	Matches no record

Candidate records not used. The form and the SPN40 number point at different records of the same study; the record confirmed by both, then the one on the form, was used. Confirm the right record, then fix the form or add a line to config/id_overrides.csv.

Participant	Study	Record not used	Found by
SPN40_CMH_50002/90073	SPIN-R	SPN31_CMH_050008	form
SPN40_CMH_100132	SPIN-R	SPN31_CMH_100132	number

Date of birth or sex differs. SPINAPS demographics against each linked origin record. A difference means a typing error in one study, or a link to the wrong person. Dates of birth are entered as the 15th of the month, so differences up to 31 days are ignored.

Participant	Study	origin_id	SPINAPS DOB	Origin DOB	DOB differs by (days)	SPINAPS sex	Origin sex
SPN40_CMH_100020	SPIN-ASD	SPASD_CMP_0020	1996-05-15	1996-01-15	121	Female	Female
SPN40_CMH_100020	SPIN-R	SPN31_CMH_100020	1996-05-15	1996-01-15	121	Female	Female
SPN40_CMH_100068	SPIN-R	SPN31_CMH_100068	1997-09-15	1996-09-15	365	Female	Female
SPN40_CMH_100094	SPIN-ASD	SPASD_CMP_0094	1989-03-15	1987-04-15	700	Male	Male
SPN40_CMH_100094	SPIN-R	SPN31_CMH_100094	1989-03-15	1987-04-15	700	Male	Male

No linked origin record. These participants contribute nothing to the From origin study tabs.

Participant	Group
SPN40_CMH_90037	Not assigned
SPN40_CMH_500010/90076	Not assigned

All links. Every SPINAPS participant and the origin records used, with how each link was found: form + number (the Shared Data form and the SPN40 number agree), form or number only, or override.

Participant	Group	Study	Origin ID	Found by
SPN40_CMH_0116	ASD-Impaired	SPIN-ASD	SPASD_CMP_0116	form + number
SPN40_CMH_0118	ASD-Impaired	SPIN-ASD	SPASD_CMP_0118	form + number
SPN40_CMH_0122	TDC	SPIN-ASD	SPASD_CMP_0122	form + number
SPN40_CMH_0135	TDC	SPIN-ASD	SPASD_CMP_0135	form + number
SPN40_CMH_0142	ASD-Impaired	SPIN-ASD	SPASD_CMP_0142	form + number
SPN40_CMH_0146	ASD-Impaired	SPIN-ASD	SPASD_CMP_0146	number
SPN40_CMH_0146	ASD-Impaired	SPIN-R	SPN31_CMH_100146	form
SPN40_CMH_0156/90102	TDC	SPIN-ASD	SPASD_CMP_0156	number
SPN40_CMH_0157/90079	TDC	SPIN-ASD	SPASD_CMP_0157	form + number
SPN40_CMH_0158/90080	TDC	SPIN-ASD	SPASD_CMP_0158	form + number
SPN40_CMH_0159/90086	TDC	SPIN-ASD	SPASD_CMP_0159	form + number
SPN40_CMH_100002	ASD-Impaired	SPIN-R	SPN31_CMH_100002	form + number
SPN40_CMH_100003	ASD-Impaired	SPIN-ASD	SPASD_CMP_0003	form
SPN40_CMH_100003	ASD-Impaired	SPIN-R	SPN31_CMH_100003	form + number
SPN40_CMH_100006	ASD-Impaired	SPIN-R	SPN31_CMH_100006	form + number
SPN40_CMH_100012	ASD-Intact	SPIN-ASD	SPASD_CMP_0012	form
SPN40_CMH_100012	ASD-Intact	SPIN-R	SPN31_CMH_100012	form + number
SPN40_CMH_100020	ASD-Impaired	SPIN-ASD	SPASD_CMP_0020	form
SPN40_CMH_100020	ASD-Impaired	SPIN-R	SPN31_CMH_100020	form + number
SPN40_CMH_100029	ASD-Impaired	SPIN-ASD	SPASD_CMP_0029	form
SPN40_CMH_100029	ASD-Impaired	SPIN-R	SPN31_CMH_100029	form + number
SPN40_CMH_100035	ASD-Impaired	SPIN-R	SPN31_CMH_100035	form + number
SPN40_CMH_100036	ASD-Impaired	SPIN-R	SPN31_CMH_100036	form + number
SPN40_CMH_100047	ASD-Impaired	SPIN-R	SPN31_CMH_100047	form + number
SPN40_CMH_100056	ASD-Impaired	SPIN-R	SPN31_CMH_100056	form + number
SPN40_CMH_100060	ASD-Impaired	SPIN-ASD	SPASD_CMP_0060	form
SPN40_CMH_100060	ASD-Impaired	SPIN-R	SPN31_CMH_100060	form + number
SPN40_CMH_100068	ASD-Impaired	SPIN-R	SPN31_CMH_100068	form + number
SPN40_CMH_100070	ASD-Impaired	SPIN-ASD	SPASD_CMP_0070	form
SPN40_CMH_100070	ASD-Impaired	SPIN-R	SPN31_CMH_100070	form + number
SPN40_CMH_100091	ASD-Impaired	SPIN-R	SPN31_CMH_100091	form + number
SPN40_CMH_100094	TDC	SPIN-ASD	SPASD_CMP_0094	form
SPN40_CMH_100094	TDC	SPIN-R	SPN31_CMH_100094	form + number
SPN40_CMH_100104	Not assigned	SPIN-R	SPN31_CMH_100104	form + number
SPN40_CMH_100113	ASD-Impaired	SPIN-ASD	SPASD_CMP_0113	form
SPN40_CMH_100115	ASD-Impaired	SPIN-ASD	SPASD_CMP_0115	form
SPN40_CMH_100117	TDC	SPIN-R	SPN31_CMH_100117	form + number
SPN40_CMH_100119	TDC	SPIN-R	SPN31_CMH_100119	form + number
SPN40_CMH_100125	ASD-Impaired	SPIN-ASD	SPASD_CMP_0125	form
SPN40_CMH_100125	ASD-Impaired	SPIN-R	SPN31_CMH_100125	number
SPN40_CMH_100132	TDC	SPIN-R	SPN30_CMH_010158	form
SPN40_CMH_100133	ASD-Impaired	SPIN-ASD	SPASD_CMP_0133	form
SPN40_CMH_50001	TDC	SPIN-R	SPN30_CMH_050001	form + number
SPN40_CMH_50002/90073	TDC	SPIN-R	SPN30_CMH_050002	form + number
SPN40_CMH_50004	TDC	SPIN-R	SPN30_CMH_050004	form + number
SPN40_CMH_50005	TDC	SPIN-R	SPN31_CMH_050005	form + number
SPN40_CMH_50006/90087	TDC	SPIN-R	SPN31_CMH_050006	form + number
SPN40_CMH_50007/90075	TDC	SPIN-R	SPN31_CMH_050007	form + number
SPN40_CMH_50008/90081	TDC	SPIN-R	SPN31_CMH_050008	form + number
SPN40_CMH_50010/90084	Not assigned	SPIN-R	SPN31_CMH_050010	number
SPN40_CMH_50013/90091	TDC	SPIN-R	SPN30_CMH_050013	form + number
SPN40_CMH_50016/90108	Not assigned	SPIN-R	SPN30_CMH_050016	number
SPN40_CMH_50017/90105	TDC	SPIN-R	SPN30_CMH_050017	number
SPN40_CMH_60001	ASD-Impaired	SPIN-R	SPN31_CMH_060001	form + number
SPN40_CMH_60003	Not assigned	SPIN-R	SPN31_CMH_060003	form + number
SPN40_CMH_60004	Not assigned	SPIN-R	SPN31_CMH_060004	form + number

Shared Data form

Ticked as shared, not found. Assessments ticked on the Shared Data Availability checklist that none of the participant’s linked origin records contain. Either the assessment is in a study not linked here (e.g. TAY or SYNAPSIS), the link is wrong, or the tick is wrong.

Participant	Instrument	Records searched
SPN40_CMH_50006/90087	BPRS	SPN31_CMH_050006
SPN40_CMH_60001	WASI-II	SPN31_CMH_060001
SPN40_CMH_60003	ADOS-2	SPN31_CMH_060003
SPN40_CMH_60003	WASI-II	SPN31_CMH_060003
SPN40_CMH_60004	BPRS	SPN31_CMH_060004
SPN40_CMH_60004	MATRICS	SPN31_CMH_060004
SPN40_CMH_60004	WASI-II	SPN31_CMH_060004
SPN40_CMH_100002	ADOS-2	SPN31_CMH_100002
SPN40_CMH_100002	Edinburgh Handedness	SPN31_CMH_100002
SPN40_CMH_100002	WASI-II	SPN31_CMH_100002
SPN40_CMH_100036	ADOS-2	SPN31_CMH_100036
SPN40_CMH_100036	WASI-II	SPN31_CMH_100036
SPN40_CMH_100047	ADOS-2	SPN31_CMH_100047
SPN40_CMH_100047	Edinburgh Handedness	SPN31_CMH_100047
SPN40_CMH_100047	WASI-II	SPN31_CMH_100047
SPN40_CMH_100056	ADOS-2	SPN31_CMH_100056
SPN40_CMH_100056	Edinburgh Handedness	SPN31_CMH_100056
SPN40_CMH_100056	WASI-II	SPN31_CMH_100056
SPN40_CMH_100091	ADOS-2	SPN31_CMH_100091
SPN40_CMH_100091	Edinburgh Handedness	SPN31_CMH_100091
SPN40_CMH_100091	WASI-II	SPN31_CMH_100091

Checklist vs origin records, by instrument. Found, not ticked usually means the checklist was not completed in full; it matters if the assessment was meant to be repeated in SPINAPS instead.

Instrument	Ticked and found	Found, not ticked	Ticked, not found
Parental education	5	42	0
ER-40	26	21	0
Edinburgh Handedness	18	16	4
MATRICS	28	16	1
ABAS-III	31	14	0
Birchwood SFS	36	11	0
WASI-II	19	11	8
RMET	38	9	0
AQ	40	7	0
TASIT-R	39	7	0
ADOS-2	12	3	6
BPRS	24	1	2

Dates and PET QC

Impossible dates. Dates of assessment in the future, PETs dated before the eligibility assessment, and PET QC dated before the PET.

Participant	Issue	Detail
SPN40_CMH_100006	PET QC dated before the PET	pet_doa = 2023-05-26, pet_qc_doa = 2022-06-19
SPN40_CMH_100056	PET before eligibility assessment	elg_doa = 2022-11-10, pet_doa = 2022-10-13
SPN40_CMH_100115	PET before eligibility assessment	elg_doa = 2022-11-21, pet_doa = 2022-11-17
SPN40_CMH_60004	Date in the future	demo_doa = 2026-11-26
SPN40_CMH_60004	Date in the future	npmed_doa = 2026-11-26

PET QC backlog. PETs whose Reconstructed PET Image QC form is still empty more than 30 days after the scan. Until QC is done they cannot count towards the targets.

Participant	Group	PET date	Days waiting
SPN40_CMH_50007/90075	TDC	2025-05-09	535
SPN40_CMH_50002/90073	TDC	2025-05-23	521
SPN40_CMH_0157/90079	TDC	2025-06-10	503
SPN40_CMH_50008/90081	TDC	2025-06-18	495
SPN40_CMH_0158/90080	TDC	2025-07-31	452
SPN40_CMH_0159/90086	TDC	2025-08-29	423
SPN40_CMH_50013/90091	TDC	2025-09-16	405
SPN40_CMH_60004	Not assigned	2025-12-03	327
SPN40_CMH_60003	Not assigned	2026-02-27	241
SPN40_CMH_0156/90102	TDC	2026-05-06	173
SPN40_CMH_50017/90105	TDC	2026-06-10	138

Values

Outside the range, not a number, or a missing-data code. Scores from both sources, and the other checked SPINAPS fields, against their valid range (table below). These values are left out of every table and plot. REDCap missing-data codes (e.g. ASKU) are read as missing and listed for completeness. Source is SPINAPS REDCap, the origin scores used in this report, or the origin record where a value that is not a number was found.

Participant	Group	Source	Field	Value	Issue
SPN40_CMH_0158/90080	TDC	SPINAPS REDCap	BMI	10000	Outside 12 to 60
SPN40_CMH_100132	TDC	SPINAPS REDCap	PET injected mass (ug)	4584	Outside 0 to 10
SPN40_CMH_60001	ASD-Impaired	SPIN-R SPN31_CMH_060001	WASI-II: Composite Score	NI	REDCap missing-data code (read as missing)
SPN40_CMH_60003	Not assigned	SPIN-R SPN31_CMH_060003	WASI-II: Composite Score	NI	REDCap missing-data code (read as missing)

Scores of 0 treated as not administered. A TASIT-R part total of 0, or an ER-40 total, happy, angry or neutral score of 0, cannot come from a test that was taken (the same rule as the SPINR dashboard). These scores (for an ER-40 total of 0, all ER-40 scores) are left out; confirm the test was not given, or correct the score.

No scores of 0 treated as not administered.

Ranges used. From each field’s REDCap validation where it has one; otherwise from config/score_ranges.csv, which says how the range was worked out. Origin-study scores are checked under their SPINAPS names (the validation is the same in SPIN-ASD and SPIN-R).

Field	Measure	Min	Max	Source
er40_cr	ER-40: ER40_CR (column K)	0	40	REDCap validation
er40_crt	ER-40: ER40_RTCR (column L)	0	6000	REDCap validation
er40ang	ER-40: ER40_ANG (column R)	0	8	REDCap validation
er40fear	ER-40: ER40_FEAR (column S)	0	8	REDCap validation
er40hap	ER-40: ER40_HAP (column T)	0	8	REDCap validation
er40noe	ER-40: ER40_NOE (column U)	0	8	REDCap validation
er40sad	ER-40: ER40_SAD (column V)	0	8	REDCap validation
wasi_wais_fsiq	WASI-II: WAIS FSIQ	0	200	REDCap validation
wasi_fsiq4_cs	WASI-II: Composite Score	40	160	REDCap validation
wasi_fsiq2_cs	WASI-II: Composite Score	40	160	REDCap validation
np_domain_tscore_process_speed	MATRICS: Processing Speed	-10	100	REDCap validation
np_domain_tscore_att_vigilance	MATRICS: Attention/Vigilance	-10	100	REDCap validation
np_domain_tscore_work_mem	MATRICS: Working Memory	-10	100	REDCap validation
np_domain_tscore_visual_learning	MATRICS: Visual Learning	-10	100	REDCap validation
np_domain_tscore_reasoning_ps	MATRICS: Reasoning/PS	-10	100	REDCap validation
np_domain_tscore_social_cog	MATRICS: Social Cognition	-10	100	REDCap validation
np_composite_tscore	MATRICS: Overall (-10-100)	-10	100	REDCap validation
demo_age_study_entry	Age at study entry	16	35	Protocol inclusion criterion (calc; no REDCap validation)
hwv_bmi	BMI	12	60	Plausible adult range (calc; no REDCap validation)
pet_inject_amount	PET injected dose (mCi)	0	10	REDCap validation minimum 0; maximum set here (REDCap has none)
pet_inject_mass	PET injected mass (ug)	0	10	REDCap validation minimum 0; maximum set here (REDCap has none)
phq9_calc	PHQ-9 total	0	27	9 items scored 0-3 (calc)
gad_total	GAD-7 total	0	21	7 items scored 0-3 (calc)
np_domain_tscore_verbal_learning	MATRICS Verbal Learning (T-score)	-10	100	No REDCap validation in SPINAPS; same as the other MATRICS T-scores
rmet_total	RMET total	0	36	36 items scored 0/1 (calc)
tasit_correct_total	TASIT-R part 1 total	0	28	7 emotions x 4 items scored 0/1 (calc)
tasit_part2_grandtotal	TASIT-R part 2 total	0	60	15 vignettes x 4 questions scored 0/1 (calc)
tasit_part3_total	TASIT-R part 3 total (sarcasm + lies)	0	64	Sum of the part 3 sarcasm and lies totals; 0-64 as on the SPIN-ASD form
ados_css_overall	ADOS-2 overall CSS	1	10	Calibrated severity score: the calc maps the algorithm total to 1-10
ados_css_sa	ADOS-2 social affect CSS	1	10	Calibrated severity score: the calc maps the SA total to 1-10
ados_css_rrb	ADOS-2 RRB CSS	1	10	Calibrated severity score: the calc maps the RRB total to 1-10
ados_abd_tot	ADOS-2 SA + RRB total	0	30	15 algorithm items converted to 0-2 (calc)
aq_total	AQ total	0	50	50 items scored 0/1 (calc)
bprs_factor_total	BPRS total	18	126	18 items rated 1-7 (calc)
bprs_factor_pos_symp	BPRS positive symptoms	4	28	4 items rated 1-7 (calc)
bprs_factor_neg_symp	BPRS negative symptoms	3	21	3 items rated 1-7 (calc)
bprs_factor_anxiety_depression	BPRS anxiety/depression	4	28	4 items rated 1-7 (calc)
bprs_factor_activation	BPRS activation	3	21	3 items rated 1-7 (calc)
bprs_factor_hostility	BPRS hostility/suspiciousness	3	21	3 items rated 1-7 (calc)
bsfs_sec_grandtotal1	Birchwood SFS total (employed)	7	247	Sum of the section totals, ranges as labelled in REDCap (0-15, 0-30, 0-66, 0-48, 0-39, 0-39, employed 7-10)
bsfs_sec_grandtotal2	Birchwood SFS total (not employed)	0	243	Sum of the section totals, ranges as labelled in REDCap (0-15, 0-30, 0-66, 0-48, 0-39, 0-39, not employed 0-6)
abas_gac1	ABAS-III GAC	40	160	Standard score (mean 100, SD 15), 4 SD either side; no REDCap validation
abas_conc1	ABAS-III conceptual	40	160	Standard score (mean 100, SD 15), 4 SD either side; no REDCap validation
abas_social1	ABAS-III social	40	160	Standard score (mean 100, SD 15), 4 SD either side; no REDCap validation
abas_prac1	ABAS-III practical	40	160	Standard score (mean 100, SD 15), 4 SD either side; no REDCap validation
hand_laterality_quotient	Edinburgh laterality quotient	-1	1	(R - L) / (R + L) (calc)

Specific activity. The PET form’s specific-activity fields have no units, and the values span several orders of magnitude. Values more than 10 times away from the field’s median are listed: probably a different unit (e.g. GBq/µmol vs mCi/µmol). These fields are not used in this report until the unit is agreed.

Participant	Field	Value	Field median
SPN40_CMH_100029	Specific activity at synthesis	5.630	4168
SPN40_CMH_100117	Specific activity at synthesis	7.310	4168
SPN40_CMH_100119	Specific activity at synthesis	10.390	4168
SPN40_CMH_100132	Specific activity at synthesis	1.292	4168
SPN40_CMH_100002	Specific activity at injection	174.500	3768
SPN40_CMH_100006	Specific activity at injection	214.300	3768
SPN40_CMH_100012	Specific activity at injection	68.200	3768
SPN40_CMH_100070	Specific activity at injection	197.640	3768
SPN40_CMH_100125	Specific activity at injection	85.800	3768

Totals from forms not marked completed. REDCap’s total-score calculations add up whichever items were answered, so a total from a form that is partly filled in, or marked not completed, can be too low. Listed: calculated totals that are range-checked here, whose form is not marked completed. They are still used; complete or correct the form.

No totals from forms that are not marked completed.

REDCap forms

Checks on each form’s “Was this form completed?” answer (or REDCap’s own form status, for AQ and ABAS-III) against what is entered, from the same data as the Assessment Completion heatmaps. Dates, rater, notes and other administrative fields don’t count as entered data. A form version marked not completed is not checked when the other version of the same form (ABAS-III) is marked completed.

Marked completed, but no data entered. The form says it was completed, but none of its questions are answered. Enter the data, or correct the answer.

None.

Data entered, but not marked completed. Questions are answered, but “Was this form completed?” is empty (or REDCap’s status is Incomplete). Answer it.

None.

Marked not completed, but has data. The form says it was not completed, but has answers. If it was partly done, mark it Partial (where the form allows it).

None.

Marked not completed, no reason given. The form says it was not completed, but “Why was this form not completed?” is empty.

None.

Reason “Other” with no explanation. The reason is “Other”, but the explanation is empty.

None.

Eligibility

No group or eligibility. Participants with no group on the Eligibility Checklist, or not recorded as eligible. They are counted as Not assigned throughout.

Participant	Group	Eligible	Eligibility date	PET date	Withdrawn
SPN40_CMH_50010/90084	Not assigned	Not recorded			No
SPN40_CMH_50016/90108	Not assigned	Not recorded			No
SPN40_CMH_60003	Not assigned	Yes	2026-02-26	2026-02-27	No
SPN40_CMH_60004	Not assigned	Yes	2025-11-26	2025-12-03	No
SPN40_CMH_90037	Not assigned	Not recorded			No
SPN40_CMH_100104	Not assigned	Not recorded			Yes
SPN40_CMH_500010/90076	Not assigned	Not recorded			No

Recorded subgroup differs from the protocol rule. From the Group Assignment Check, using origin-study scores.

Participant	Recorded group	Group by rule	Below cut-off
SPN40_CMH_0118	ASD-Impaired	ASD-Intact
SPN40_CMH_0146	ASD-Impaired	ASD-Intact
SPN40_CMH_100003	ASD-Impaired	ASD-Intact
SPN40_CMH_100012	ASD-Intact	ASD-Impaired	RMET
SPN40_CMH_100060	ASD-Impaired	ASD-Intact
SPN40_CMH_100070	ASD-Impaired	ASD-Intact
SPN40_CMH_100125	ASD-Impaired	ASD-Intact
SPN40_CMH_100133	ASD-Impaired	ASD-Intact
SPN40_CMH_100002	ASD-Impaired	ASD-Intact (incomplete scores)
SPN40_CMH_100047	ASD-Impaired	ASD-Intact (incomplete scores)
SPN40_CMH_100056	ASD-Impaired	ASD-Intact (incomplete scores)
SPN40_CMH_100068	ASD-Impaired	ASD-Intact (incomplete scores)
SPN40_CMH_60001	ASD-Impaired	ASD-Intact (incomplete scores)

Enrolled outside age 16-35. The protocol includes participants aged 16-35. Age at the eligibility assessment, from the date of birth (or the Demographics age at study entry when a date is missing).

Every enrolled participant was 16-35 at eligibility.

Enrolled with IQ < 70. IQ < 70 (WASI-II or WAIS-IV) is an exclusion criterion for everyone. Listed: enrolled participants with a full-scale IQ below 70 in SPINAPS or the origin study.

No enrolled participant has IQ < 70.

TDC to confirm. Typically developing controls must have no DSM-5 disorder, except adjustment disorder, phobic disorder, or a single past major depressive episode at least two years ago and not currently treated. Listed: TDC with any lifetime diagnosis on their origin SCID, or a current psychotropic medication in SPINAPS. Whether an exception applies is for the study team to confirm.

Participant	Issue	Detail
SPN40_CMH_0135	SCID diagnosis (origin study, lifetime)	Major depressive disorder
SPN40_CMH_0156/90102	SCID diagnosis (origin study, lifetime)	Bulimia nervosa
SPN40_CMH_0157/90079	SCID diagnosis (origin study, lifetime)	Major depressive disorder
SPN40_CMH_0135	Current psychotropic medication	SSRI: fluoxetine

SCID

SCID data entry gaps. From the SCID section’s per-disorder tables, for each source: a disorder selected with its ratings left empty; a disorder at lifetime threshold whose current rating (asked because of that) is empty; “clinical disorder present” answered Yes with no disorder selected. For the origin study, the SCID used is the one closest to the PET.

Check	Participant	Group	Source	Disorder
Lifetime threshold, current rating not entered	SPN40_CMH_0116	ASD-Impaired	From origin study	Posttraumatic stress disorder

REDCap setup

Forms not exported. Forms in the data dictionary for which the REDCap API returns no fields. This usually means the API user has no export rights on the form; ask the REDCap administrator to grant them.

Form
SCID-5

Medication names not classified. Psychotropic medication names that match no pattern in config/med_classes.csv. Add a line there to classify them.

Every medication name is classified.

SPINAPS Study Tracking

Hassan Abdulrasul

2026-10-26

Overview: progress towards the PET targets

Recruitment

By month

Where participants came from

Withdrawals

Participant Flow

Flow

Participants

Descriptive Statistics

SPINAPS REDCap

From origin study

Distributions

Age

Sex

Gender

Education

IQ (origin study)

Data Sharing

Sources

Shared assessments

MRI

Age of shared assessments

Assessment Completion

SPINAPS REDCap

ASD-Impaired

ASD-Intact

TDC

Not assigned

From origin study

ASD-Impaired

ASD-Intact

TDC

Not assigned

Group Assignment Check

SPINAPS REDCap

From origin study

Structured Clinical Interview for DSM Disorders (SCID)

SPINAPS REDCap

Current

Lifetime

Past only

From origin study

Current

Lifetime

Past only

Clinical Scores

Autism-Spectrum Quotient (AQ)

SPINAPS REDCap

From origin study

ADOS-2

SPINAPS REDCap

From origin study

Brief Psychiatric Rating Scale (BPRS)

SPINAPS REDCap

From origin study

PHQ-9 and GAD-7

SPINAPS REDCap

From origin study

Cognition

IQ (WASI-II / WAIS-IV)

SPINAPS REDCap

From origin study

MATRICS Consensus Cognitive Battery

SPINAPS REDCap

From origin study

Reading the Mind in the Eyes Test (RMET)

SPINAPS REDCap

From origin study

The Awareness of Social Inference Test (TASIT-R)

SPINAPS REDCap

From origin study

Penn Emotion Recognition Test (ER-40)

SPINAPS REDCap

From origin study

Functioning

Birchwood Social Functioning Scale (SFS)

SPINAPS REDCap