Overview: progress towards the PET targets

How this is counted. Each participant is counted once, at the furthest point they have reached: enrolled (has a SPINAPS record), eligible (Eligibility Checklist says eligible), PET done (PET Scan Information form completed), then PET usable on QC. A PET whose QC form is still empty is shown as QC pending rather than unusable, because no QC decision has been made yet. Targets count usable PETs only, because the protocol replaces participants whose PET cannot be used. The pilot target (Aim 1) is 10 per group; the full sample (Aim 2) is 28 ASD-Impaired, 27 ASD-Intact and 29 TDC (config/targets.csv).

Group	Enrolled	Eligible	PET done	QC pending	PET usable	Withdrawn	Pilot (Aim 1)		Full sample (Aim 2)
Group	Enrolled	Eligible	PET done	QC pending	PET usable	Withdrawn	Pilot target	Pilot met	Full target	Full met	Still needed
ASD-Impaired	22	22	21	0	21	0	10	210%	28	75%	7
ASD-Intact	1	1	1	0	1	0	10	10%	27	4%	26
TDC	19	19	19	9	10	0	10	100%	29	34%	19
Not assigned	4	2	2	2	0	1
TOTAL	46	44	43	11	32	1	30	107%	84	38%	52
Notes. Counts are participants. PET usable = reconstructed image judged usable on QC; QC pending = PET done but the QC form is not filled in yet. Targets count usable PETs only. Not assigned = no group recorded on the Eligibility Checklist (no target).

Recruitment

How this is counted. There is no e-consent project for SPINAPS, so a participant is counted as recruited in the month of their eligibility assessment (elg_doa, Eligibility Checklist), the first study procedure after consent. Participants without an eligibility date are left out of these plots (2 at present).

Withdrawals

How this is counted. A participant is withdrawn when the Early Termination/Withdrawal Checklist says they were prematurely withdrawn (term_premature_yn); the reason is the one ticked on that form. This includes participants who never received a group, so they appear under Not assigned.

Reason	Not assigned
Lost to follow-up	1

Descriptive Statistics

SPINAPS REDCap

What is shown. Everyone with a SPINAPS record, by group, using the SPINAPS Demographics and Height/Weight/Vitals forms. Gender is shown as recorded (check all that apply; none of the current participants ticked more than one). Mother’s education has two fields on the form and either is used. Handedness and parental education are only filled in for a few participants in SPINAPS; the From origin study tab adds them from the study each participant came from. Values entered as REDCap missing-data codes (e.g. ASKU) or outside their valid range count as missing.

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=4)	Overall (N=46)
Age at study entry (years)
Mean (SD)	24 (± 4.7)	28 (± NA)	25 (± 5.3)	21 (± 4.2)	25 (± 5.0)
Median [Min, Max]	24 [17, 35]	28 [28, 28]	23 [18, 33]	21 [16, 25]	23 [16, 35]
Sex assigned at birth
Female	12 (55 %)	0 (0 %)	9 (47 %)	2 (50 %)	23 (50 %)
Male	10 (45 %)	1 (100 %)	10 (53 %)	2 (50 %)	23 (50 %)
Gender identity
Gender fluid	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
Man	9 (41 %)	0 (0 %)	10 (53 %)	2 (50 %)	21 (46 %)
Non-binary	1 (5 %)	0 (0 %)	1 (5 %)	0 (0 %)	2 (4 %)
Not listed	1 (5 %)	0 (0 %)	0 (0 %)	1 (25 %)	2 (4 %)
Trans woman	0 (0 %)	1 (100 %)	0 (0 %)	0 (0 %)	1 (2 %)
Woman	9 (41 %)	0 (0 %)	8 (42 %)	1 (25 %)	18 (39 %)
Handedness
Left	0 (0 %)	0 (0 %)	0 (0 %)	1 (25 %)	1 (2 %)
Right	0 (0 %)	0 (0 %)	4 (21 %)	2 (50 %)	6 (13 %)
Missing	22 (100%)	1 (100%)	15 (78.9%)	1 (25.0%)	39 (84.8%)
Education (years)
Mean (SD)	14 (± 2.0)	12 (± NA)	16 (± 2.1)	12 (± 2.6)	15 (± 2.4)
Median [Min, Max]	14 [10, 17]	12 [12, 12]	16 [12, 20]	12 [10, 16]	15 [10, 20]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	0 (0%)	2 (4.3%)
Mother's education (years)
Mean (SD)	NA (± NA)	NA (± NA)	14 (± 2.3)	19 (± 1.0)	16 (± 3.2)
Median [Min, Max]	NA [NA, NA]	NA [NA, NA]	14 [12, 16]	19 [18, 20]	16 [12, 20]
Missing	22 (100%)	1 (100%)	15 (78.9%)	1 (25.0%)	39 (84.8%)
Father's education (years)
Mean (SD)	NA (± NA)	NA (± NA)	15 (± 2.0)	18 (± 2.0)	16 (± 2.4)
Median [Min, Max]	NA [NA, NA]	NA [NA, NA]	16 [12, 16]	18 [16, 20]	16 [12, 20]
Missing	22 (100%)	1 (100%)	15 (78.9%)	1 (25.0%)	39 (84.8%)
BMI (kg/m²)
Mean (SD)	27 (± 7.1)	27 (± NA)	24 (± 3.4)	29 (± 11)	26 (± 6.0)
Median [Min, Max]	28 [15, 43]	27 [27, 27]	24 [19, 31]	29 [21, 36]	25 [15, 43]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	2 (50.0%)	4 (8.7%)

From origin study

What is shown. The SPINAPS demographics above, with the measures that come from the referring study (the assessment closest to the PET; see Data Sharing): IQ, handedness from the Edinburgh Handedness Inventory (laterality quotient from −1, fully left, to +1, fully right; ≥ 0.5 counted as right, ≤ −0.5 as left, in between as mixed) and parental education.

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=4)	Overall (N=46)
Age at study entry (years)
Mean (SD)	24 (± 4.7)	28 (± NA)	25 (± 5.3)	21 (± 4.2)	25 (± 5.0)
Median [Min, Max]	24 [17, 35]	28 [28, 28]	23 [18, 33]	21 [16, 25]	23 [16, 35]
Sex assigned at birth
Female	12 (55 %)	0 (0 %)	9 (47 %)	2 (50 %)	23 (50 %)
Male	10 (45 %)	1 (100 %)	10 (53 %)	2 (50 %)	23 (50 %)
Gender identity
Gender fluid	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
Man	9 (41 %)	0 (0 %)	10 (53 %)	2 (50 %)	21 (46 %)
Non-binary	1 (5 %)	0 (0 %)	1 (5 %)	0 (0 %)	2 (4 %)
Not listed	1 (5 %)	0 (0 %)	0 (0 %)	1 (25 %)	2 (4 %)
Trans woman	0 (0 %)	1 (100 %)	0 (0 %)	0 (0 %)	1 (2 %)
Woman	9 (41 %)	0 (0 %)	8 (42 %)	1 (25 %)	18 (39 %)
Education (years)
Mean (SD)	14 (± 2.0)	12 (± NA)	16 (± 2.1)	12 (± 2.6)	15 (± 2.4)
Median [Min, Max]	14 [10, 17]	12 [12, 12]	16 [12, 20]	12 [10, 16]	15 [10, 20]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	0 (0%)	2 (4.3%)
Full-scale IQ
Mean (SD)	120 (± 15)	110 (± NA)	120 (± 14)	NA (± NA)	120 (± 14)
Median [Min, Max]	120 [89, 140]	110 [110, 110]	120 [84, 140]	NA [NA, NA]	120 [84, 140]
Missing	9 (40.9%)	0 (0%)	4 (21.1%)	4 (100%)	17 (37.0%)
Handedness (Edinburgh)
Left	1 (5 %)	0 (0 %)	2 (11 %)	0 (0 %)	3 (7 %)
Mixed	4 (18 %)	0 (0 %)	2 (11 %)	1 (25 %)	7 (15 %)
Right	9 (41 %)	1 (100 %)	12 (63 %)	1 (25 %)	23 (50 %)
Missing	8 (36.4%)	0 (0%)	3 (15.8%)	2 (50.0%)	13 (28.3%)
Laterality quotient
Mean (SD)	0.48 (± 0.49)	0.87 (± NA)	0.55 (± 0.55)	0.10 (± 0.57)	0.51 (± 0.52)
Median [Min, Max]	0.69 [-0.67, 1.0]	0.87 [0.87, 0.87]	0.70 [-0.87, 1.0]	0.10 [-0.30, 0.50]	0.67 [-0.87, 1.0]
Missing	8 (36.4%)	0 (0%)	3 (15.8%)	2 (50.0%)	13 (28.3%)
Mother's education (years)
Mean (SD)	16 (± 2.2)	12 (± NA)	15 (± 2.6)	17 (± 2.1)	16 (± 2.4)
Median [Min, Max]	16 [12, 20]	12 [12, 12]	16 [11, 20]	16 [15, 19]	16 [11, 20]
Missing	0 (0%)	0 (0%)	0 (0%)	1 (25.0%)	1 (2.2%)
Father's education (years)
Mean (SD)	16 (± 2.2)	11 (± NA)	16 (± 2.4)	17 (± 1.2)	16 (± 2.3)
Median [Min, Max]	16 [12, 20]	11 [11, 11]	16 [12, 20]	16 [16, 18]	16 [11, 20]
Missing	0 (0%)	0 (0%)	0 (0%)	1 (25.0%)	1 (2.2%)
BMI (kg/m²)
Mean (SD)	27 (± 7.1)	27 (± NA)	24 (± 3.4)	29 (± 11)	26 (± 6.0)
Median [Min, Max]	28 [15, 43]	27 [27, 27]	24 [19, 31]	29 [21, 36]	25 [15, 43]
Missing	1 (4.5%)	0 (0%)	1 (5.3%)	2 (50.0%)	4 (8.7%)

Distributions

What is shown. The spread of the main descriptive variables by group, for everyone with a SPINAPS record (one bin = one year of age or education; 5 IQ points). Groups are overlaid, so where they overlap the colours mix. IQ comes from the origin studies (see Data Sharing), because no IQ has been entered in SPINAPS REDCap yet.

Age

Sex

Gender

Education

IQ (origin study)

Data Sharing

Most SPINAPS participants took part in SPIN-ASD or SPIN-R first, and the protocol reuses their assessments and MRI instead of repeating them. This section shows where each participant’s data came from, using the Shared Data Availability form and the origin studies’ REDCap projects.

Sources

How this is counted. The studies ticked on the Shared Data Availability form, separately for clinical data and MRI. A participant who was in SPIN-ASD and then SPIN-R can have both ticked.

Clinical data shared from	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
None recorded	0	0	2	1	3
SPIN-ASD	7	0	5	0	12
SPIN-ASD + SPIN-R	5	1	1	0	7
SPIN-R	10	0	11	3	24

MRI shared from	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
None recorded	0	0	2	1	3
SPIN-ASD	7	0	6	0	13
SPIN-R	15	1	11	3	30

Shared assessments

How this is read. One row per participant (sorted by group), one column per assessment on the form’s checklist. Green = ticked as shared from the referring study. Assessments not ticked were either done in SPINAPS or are not available.

MRI

Why it matters. SPINAPS does not repeat the MRI when a good-quality one exists from the referring study. Multi-shell diffusion is needed for the NODDI analyses in the exploratory aim, so it is counted separately.

Shared MRI quality	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
Good	7	0	4	0	11
OK	13	1	6	2	22
Poor	0	0	0	1	1
Not recorded	2	0	9	1	12

Multi-shell DWI available	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
No	22	1	19	3	45
Yes	0	0	0	1	1

Age of shared assessments

How this is chosen. For the From origin study tabs in this report, each participant’s score on each instrument comes from their linked origin visit (SPIN-ASD, or any SPIN-R visit) closest in time to their SPINAPS PET, or to their eligibility assessment if there is no PET yet. The protocol reuses an assessment only if it is at most 6 months old (no limit for IQ), so the dashed line marks 6 months. Within 6 months counts assessments up to 6 months either side of the PET. Hover over a point for the origin record and visit.

Instrument	Participants	From SPIN-ASD	From SPIN-R	Median months before PET	Within 6 months	Older than 6 months	No date
ABAS-III	44	12	32	4.0	27	16	1
ADOS-2	15	14	1	16.2	2	13	0
AQ	45	12	33	3.7	28	16	1
BPRS	25	6	19	5.9	12	12	1
Birchwood SFS	45	12	33	5.0	27	17	1
ER-40	45	12	33	3.5	28	16	1
Edinburgh Handedness	33	21	12	5.0	18	15	0
MATRICS	42	12	30	4.0	25	16	1
Parental education	45	12	33	5.1	27	17	1
RMET	45	12	33	3.5	28	16	1
TASIT-R	44	12	32	3.6	27	16	1
WASI-II	29	21	8	7.2	12	17	0

Assessment Completion

SPINAPS REDCap

How this is read. One row per participant, one column per form, from each form’s “Was this form completed?” question. Green = completed, gold = partly completed, red = recorded as not completed, grey = nothing entered. AQ and ABAS-III have no such question, so REDCap’s own form status is used: “Incomplete” is gold when the form has some answers and grey when it was never opened. The two ABAS-III forms (summary scores and questionnaire) share one column. Hover over a cell for the recorded answer and the reason a form was not completed. Not shown: SCID-5. The REDCap API returns no fields from this form, which usually means the API user has no export rights on it.

ASD-Impaired

ASD-Intact

TDC

Not assigned

From origin study

How this is read. Whether a score for each instrument exists in the participant’s linked SPIN-ASD or SPIN-R records (see Data Sharing), and how old it is at the SPINAPS PET. Green = within 6 months, the protocol’s limit for reusing an assessment; gold = older (reusable for IQ only); grey = no origin score. Each row is labelled with the SPN40 ID and the origin record(s) it is linked to (SPIN-ASD SPASD_..., SPIN-R SPN3x_...). Hover over a cell for the study, origin ID, visit and assessment date the score came from, or, for a grey cell, which linked records were searched. This is what could be uploaded to SPINAPS now, and what would need re-assessing.

ASD-Impaired

ASD-Intact

TDC

Not assigned

Group Assignment Check

What is checked. Whether each ASD participant’s recorded subgroup (Eligibility Checklist, elg_group) matches the rule written on the same checklist. ASD-Impaired means at least one of: MATRICS composite, RMET or Birchwood SFS total at least 1 SD below the mean of the SPIN-ASD and SPINS typically developing controls aged 16-35; IQ < 90; or ABAS-III general adaptive composite < 90. Otherwise ASD-Intact.

Why the checklist rule and not the protocol’s. The protocol (3.3.2) names only IQ, MATRICS and RMET; the checklist adds SFS and ABAS-III, and it is the rule staff apply. Most participants below the cut-offs are there on SFS or ABAS-III, so the difference matters.

The control norms are computed here from the SPIN-ASD control arm and the SPINS control arm (all sites), aged 16-35 at study entry:

Measure	Controls (n)	Mean	SD	Cut-off (mean − 1 SD)
MATRICS composite (T-score)	166	49.8	10.6	39.2
RMET total	130	27.9	4.2	23.7
Birchwood SFS total	181	172.1	20.5	151.6

SPINAPS REDCap

No IQ, ABAS-III, MATRICS, RMET or SFS scores have been entered in SPINAPS REDCap yet.

From origin study

Recorded group	Group by the checklist rule
Recorded group	ASD-Impaired	ASD-Intact	ASD-Intact (incomplete scores)
ASD-Impaired	20	1	1
ASD-Intact	1	0	0

Participant	Recorded group	IQ	ABAS GAC	MATRICS (T)	RMET	SFS	Below cut-off	Group by rule	Agrees
SPN40_CMH_100003	ASD-Impaired	137	97	62	29	153		ASD-Intact	No
SPN40_CMH_60001	ASD-Impaired		96	55	26	163		ASD-Intact (incomplete scores)	No
SPN40_CMH_100012	ASD-Intact	113	96	49	23	156	RMET	ASD-Impaired	No
SPN40_CMH_0116	ASD-Impaired	89	64	49	27	86	IQ < 90, ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_0118	ASD-Impaired	123	69	46	29	93	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_0142	ASD-Impaired	117	97	9	34	119	MATRICS, SFS	ASD-Impaired	Yes
SPN40_CMH_0146	ASD-Impaired	133	88	65	28	113	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100002	ASD-Impaired		120	54	28	148	SFS	ASD-Impaired	Yes
SPN40_CMH_100006	ASD-Impaired		67	41	28	97	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100020	ASD-Impaired	105	89	41	33	138	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100029	ASD-Impaired	109	94	45	17	146	RMET, SFS	ASD-Impaired	Yes
SPN40_CMH_100035	ASD-Impaired		106	38	24	139	MATRICS, SFS	ASD-Impaired	Yes
SPN40_CMH_100036	ASD-Impaired		89	41	29	130	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100047	ASD-Impaired		86	51	31	80	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100056	ASD-Impaired		96	47	27	107	SFS	ASD-Impaired	Yes
SPN40_CMH_100060	ASD-Impaired	117	71	55	26	97	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100068	ASD-Impaired		111	49	32	151	SFS	ASD-Impaired	Yes
SPN40_CMH_100070	ASD-Impaired	121	86	47	30	138	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100091	ASD-Impaired		75	54	20	95	ABAS GAC < 90, RMET, SFS	ASD-Impaired	Yes
SPN40_CMH_100113	ASD-Impaired	137	59	35	27	86	ABAS GAC < 90, MATRICS, SFS	ASD-Impaired	Yes
SPN40_CMH_100115	ASD-Impaired	94	86	46	24	142	ABAS GAC < 90, SFS	ASD-Impaired	Yes
SPN40_CMH_100125	ASD-Impaired	127	91	62	29	150	SFS	ASD-Impaired	Yes
SPN40_CMH_100133	ASD-Impaired	120	77	52	28	159	ABAS GAC < 90	ASD-Impaired	Yes
Cut-offs (TDC mean − 1 SD): MATRICS ≤ 39.2, RMET ≤ 23.7, SFS ≤ 151.6; IQ < 90; ABAS GAC < 90. Incomplete scores: no criterion is met but at least one score is missing, so impairment cannot be ruled out.

Structured Clinical Interview for DSM Disorders (SCID)

Bars show the number of participants in each group with each SCID-5 diagnosis. A participant with several diagnoses is counted once for each.

Current: meets symptomatic criteria within the time window the SCID-5 specifies for the disorder (the past month for most; up to the past 2 years for some). Lifetime: has ever met diagnostic criteria (lifetime prevalence rated Threshold; in SPIN-ASD, any disorder recorded as meeting criteria). No diagnosis: no clinical disorder recorded. No current / lifetime diagnosis: at least one disorder recorded, but none meeting that tab’s definition.

From origin study: the SCID closest in time to the participant’s SPINAPS PET among their linked SPIN-ASD and SPIN-R visits, decoded with that study’s score sheet. The protocol reuses the SCID history when it is older than 6 months but re-assesses current status, so Current from an old SCID may be out of date. Decoding is the same as in the SPIN-R dashboard (config/scid_codes_spinr.csv, config/scid_codes_spasd.csv).

SPINAPS REDCap

Current

The SCID-5 form is not exported by the REDCap API (no fields from it are returned, which usually means the API user has no export rights on it).

Lifetime

The SCID-5 form is not exported by the REDCap API (no fields from it are returned, which usually means the API user has no export rights on it).

From origin study

Current

Lifetime

Clinical Scores

From origin study

PHQ-9 and GAD-7

Self-reported depression (PHQ-9, 0-27) and anxiety (GAD-7, 0-21) over the past two weeks. 5, 10 and 15 mark mild, moderate and (moderately) severe on both. These are SPINAPS-only questionnaires, so there is no origin tab content.

SPINAPS REDCap

Adaptive behaviour composites (standard scores, mean 100, SD 15): general adaptive composite (GAC) and the conceptual, social and practical domains. GAC < 90 is one of the ASD-Impaired criteria.

SPINAPS REDCap

No scores entered in SPINAPS REDCap yet.

From origin study

PET Session

What is shown. Participants whose PET Scan Information form is completed, by group: injected dose and mass, the arm used for the arterial line, samples collected, and whether the participant had side effects or complications from the arterial line or the scan. Technician notes are from the PET QC form (notes recorded for the scan or the blood draw). These are SPINAPS procedures, so there is no origin-study tab.

Specific activity (at synthesis and at injection) is not shown: the REDCap fields have no units and the values recorded differ by orders of magnitude, which suggests more than one unit is in use (see Data Quality). Dose and mass values outside their valid range (config/score_ranges.csv) are left out and listed under Data Quality.

	ASD-Impaired (N=21)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=2)	Overall (N=43)
Injected dose (mCi)
Mean (SD)	5.1 (± 0.31)	5.1 (± NA)	5.1 (± 0.24)	NA (± NA)	5.1 (± 0.28)
Median [Min, Max]	5.2 [4.3, 5.6]	5.1 [5.1, 5.1]	5.1 [4.8, 5.6]	NA [NA, NA]	5.1 [4.3, 5.6]
Missing	0 (0%)	0 (0%)	8 (42.1%)	2 (100%)	10 (23.3%)
Injected mass (µg)
Mean (SD)	0.50 (± 0.34)	0.84 (± NA)	0.35 (± 0.086)	NA (± NA)	0.47 (± 0.30)
Median [Min, Max]	0.38 [0.14, 1.6]	0.84 [0.84, 0.84]	0.36 [0.23, 0.51]	NA [NA, NA]	0.38 [0.14, 1.6]
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)
Arterial line arm
Left	13 (62 %)	1 (100 %)	15 (79 %)	0 (0 %)	29 (67 %)
Right	8 (38 %)	0 (0 %)	2 (11 %)	2 (100 %)	12 (28 %)
Missing	0 (0%)	0 (0%)	2 (10.5%)	0 (0%)	2 (4.7%)
Arterial blood samples collected
Yes	21 (100 %)	1 (100 %)	19 (100 %)	2 (100 %)	43 (100 %)
No	0 (0 %)	0 (0 %)	0 (0 %)	0 (0 %)	0 (0 %)
Genetic blood sample collected
Yes	21 (100 %)	1 (100 %)	18 (95 %)	2 (100 %)	42 (98 %)
No	0 (0 %)	0 (0 %)	1 (5 %)	0 (0 %)	1 (2 %)
Side effects or complications
Yes	5 (24 %)	0 (0 %)	1 (5 %)	0 (0 %)	6 (14 %)
No	16 (76 %)	1 (100 %)	18 (95 %)	2 (100 %)	37 (86 %)
Technician notes: scan
Yes	18 (86 %)	1 (100 %)	7 (37 %)	0 (0 %)	26 (60 %)
No	3 (14 %)	0 (0 %)	3 (16 %)	0 (0 %)	6 (14 %)
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)
Technician notes: blood draw
Yes	9 (43 %)	1 (100 %)	2 (11 %)	0 (0 %)	12 (28 %)
No	12 (57 %)	0 (0 %)	8 (42 %)	0 (0 %)	20 (47 %)
Missing	0 (0%)	0 (0%)	9 (47.4%)	2 (100%)	11 (25.6%)

Safety

Adverse events

What is shown. Every adverse event recorded on the Adverse Events log, one row per event. 4 participants have at least one event recorded; 37 are recorded as having none.

Participant	Group	Event	Onset	Severity	Related to study	SAE	Outcome
SPN40_CMH_0142	ASD-Impaired	Pain at the arterial line insertion	2024-04-23	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100003	ASD-Impaired	pressure point pain	2023-02-09	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100035	ASD-Impaired	Pain at arterial and venous injection sites	2023-08-17	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100115	ASD-Impaired	sensitivity to local anesthesia and/or latex gloves	2022-11-17	Mild	Definitely	No	Resolved without sequelae
SPN40_CMH_100115	ASD-Impaired	Client refused aftercare guidlines and experiences tingling due to excessive use of wrist	2022-11-18	Mild	Probably	No	Resolved without sequelae

Urine toxicology

What is shown. The urine drug screen taken on the PET day. Positive results list the drugs recorded.

Urine drug screen	ASD-Impaired	ASD-Intact	TDC	Not assigned	Total
Negative	18	1	15	0	34
Positive	1	0	3	2	6

Participant	Group	Positive for
SPN40_CMH_0142	ASD-Impaired	Only positive for drugs on conmed: Fluoxetine
SPN40_CMH_50006	TDC	Diphenhydramine
SPN40_CMH_50013/90091	TDC	Certirzine (antihistamine, not on conmed)
SPN40_CMH_60003	Not assigned	All negative other than the known prescribed medication. This information is recorded on conmed.
SPN40_CMH_60004	Not assigned	Sertaline
SPN40_CMH_100094	TDC	Amphetamine, ephedrine, metformine, pantroprazole, Quetiapine, methylphenidate, venflaxine, hydromorphone

Medications

What is shown. Current psychotropic medications from the SPINAPS Concomitant Medication Record (Psychotropic), for participants whose form is completed. The protocol re-assesses medications in SPINAPS even when they were recorded in the referring study, so there is no origin-study tab. Medication names are free text; config/med_classes.csv maps each name (including the misspellings found) to a generic name and class. Entries with a discontinuation date or marked as not continuing are left out. SSRI and antipsychotic use are matching variables in the protocol.

	ASD-Impaired (N=22)	ASD-Intact (N=1)	TDC (N=19)	Not assigned (N=3)	Overall (N=45)
Any psychotropic
Yes	11 (50 %)	0 (0 %)	1 (5 %)	2 (67 %)	14 (31 %)
No	11 (50 %)	1 (100 %)	18 (95 %)	1 (33 %)	31 (69 %)
SSRI
Yes	7 (32 %)	0 (0 %)	1 (5 %)	2 (67 %)	10 (22 %)
No	15 (68 %)	1 (100 %)	18 (95 %)	1 (33 %)	35 (78 %)
SNRI
Yes	1 (5 %)	0 (0 %)	0 (0 %)	0 (0 %)	1 (2 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	3 (100 %)	44 (98 %)
Other antidepressant
Yes	4 (18 %)	0 (0 %)	0 (0 %)	0 (0 %)	4 (9 %)
No	18 (82 %)	1 (100 %)	19 (100 %)	3 (100 %)	41 (91 %)
Antipsychotic
Yes	2 (9 %)	0 (0 %)	0 (0 %)	0 (0 %)	2 (4 %)
No	20 (91 %)	1 (100 %)	19 (100 %)	3 (100 %)	43 (96 %)
Stimulant
Yes	7 (32 %)	0 (0 %)	0 (0 %)	1 (33 %)	8 (18 %)
No	15 (68 %)	1 (100 %)	19 (100 %)	2 (67 %)	37 (82 %)
Non-stimulant ADHD
Yes	1 (5 %)	0 (0 %)	0 (0 %)	1 (33 %)	2 (4 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	2 (67 %)	43 (96 %)
Sleep
Yes	1 (5 %)	0 (0 %)	0 (0 %)	0 (0 %)	1 (2 %)
No	21 (95 %)	1 (100 %)	19 (100 %)	3 (100 %)	44 (98 %)

Data Quality

Things to correct or confirm in REDCap, collected from every part of this report. Nothing here is changed in REDCap; values outside their valid range are left out of the tables and plots above, and typed IDs are corrected only for linking. The table counts the issues of each check (green = none); the tabs list them.

Check	Issues	Participants
Origin IDs
Typed IDs to correct on the Shared Data form	18	13
Candidate records not used	2	2
Date of birth or sex differs from the origin record	5	3
Participants with no linked origin record	1	1
Shared Data form
Ticked as shared, not found in origin records	22	9
Dates and PET QC
Impossible dates	5	4
PET QC not done 30+ days after the scan	11	11
Values
Values outside their valid range	2	2
Specific activity on a different scale	9	9
Eligibility
No group or eligibility recorded	4	4
Recorded ASD subgroup differs from the checklist rule	3	3
TDC with a diagnosis or psychotropic medication	4	3
REDCap setup
Forms not exported by the API	1
Medication names not classified	0	0

Origin IDs

Typed IDs to correct. IDs on the Shared Data Availability form that are not exactly an origin record ID. Most were corrected automatically for linking (the SOASD typo, CMH for CMP in SPIN-ASD, hyphens, a trailing . or /); some match no record. Please correct them on the form so the links do not depend on these fixes.

Participant	Study	Field	Typed ID	Record used	Issue
SPN40_CMH_0116	SPIN-ASD	MRI participant ID	SOASD_CMP_0116	SPASD_CMP_0116	Corrected automatically; please fix in REDCap
SPN40_CMH_0116	SPIN-ASD	Clinical participant ID	SOASD_CMP_0116	SPASD_CMP_0116	Corrected automatically; please fix in REDCap
SPN40_CMH_0135	SPIN-ASD	MRI participant ID	SPASD_CMH_0135	SPASD_CMP_0135	Corrected automatically; please fix in REDCap
SPN40_CMH_0135	SPIN-ASD	Clinical participant ID	SPASD_CMH_0135	SPASD_CMP_0135	Corrected automatically; please fix in REDCap
SPN40_CMH_0142	SPIN-ASD	MRI participant ID	SPASD_CMP_0142.	SPASD_CMP_0142	Corrected automatically; please fix in REDCap
SPN40_CMH_0142	SPIN-ASD	Clinical participant ID	SPASD_CMP_0142.	SPASD_CMP_0142	Corrected automatically; please fix in REDCap
SPN40_CMH_0158/90080	SPIN-ASD	MRI participant ID	SPASD_CMP_0158/	SPASD_CMP_0158	Corrected automatically; please fix in REDCap
SPN40_CMH_0159/90086	SPIN-ASD	MRI participant ID	SPASD_CMP_0159/ SYNAPSIS_CMH_0086	SPASD_CMP_0159	Corrected automatically; please fix in REDCap
SPN40_CMH_50002	SPIN-R	MRI participant ID	SPN31_CMH_050002	SPN30_CMH_050002	Corrected automatically; please fix in REDCap
SPN40_CMH_60004	SPIN-R	MRI participant ID	SPN40_CMH_60004	none	Matches no record
SPN40_CMH_100003	SPIN-ASD	Clinical participant ID	SPASD-CMP-0003	SPASD_CMP_0003	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-ASD	Clinical participant ID	SPASD-CMH-0020	SPASD_CMP_0020	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-R	MRI participant ID	SPN31-CMH-100020	SPN31_CMH_100020	Corrected automatically; please fix in REDCap
SPN40_CMH_100020	SPIN-R	Clinical participant ID	SPN31-CMH-100020	SPN31_CMH_100020	Corrected automatically; please fix in REDCap
SPN40_CMH_100029	SPIN-R	Clinical participant ID	SPN31_CMH_10029	none	Matches no record
SPN40_CMH_100060	SPIN-R	Clinical participant ID	SPN31-CMH-100060	SPN31_CMH_100060	Corrected automatically; please fix in REDCap
SPN40_CMH_100091	SPIN-R	MRI participant ID	SPN31-CMH-100091	SPN31_CMH_100091	Corrected automatically; please fix in REDCap
SPN40_CMH_100104	SPIN-R	Clinical participant ID	SPN40_CMH_100104	none	Matches no record

Candidate records not used. The form and the SPN40 number point at different records of the same study; the record confirmed by both, then the one on the form, was used. Confirm the right record, then fix the form or add a line to config/id_overrides.csv.

Participant	Study	Record not used	Found by
SPN40_CMH_50002	SPIN-R	SPN31_CMH_050008	form
SPN40_CMH_100132	SPIN-R	SPN31_CMH_100132	number

Date of birth or sex differs. SPINAPS demographics against each linked origin record. A difference means a typing error in one study, or a link to the wrong person. Dates of birth are entered as the 15th of the month, so differences up to 31 days are ignored.

Participant	Study	origin_id	SPINAPS DOB	Origin DOB	DOB differs by (days)	SPINAPS sex	Origin sex
SPN40_CMH_100020	SPIN-ASD	SPASD_CMP_0020	1996-05-15	1996-01-15	121	Female	Female
SPN40_CMH_100020	SPIN-R	SPN31_CMH_100020	1996-05-15	1996-01-15	121	Female	Female
SPN40_CMH_100068	SPIN-R	SPN31_CMH_100068	1997-09-15	1996-09-15	365	Female	Female
SPN40_CMH_100094	SPIN-ASD	SPASD_CMP_0094	1989-03-15	1987-04-15	700	Male	Male
SPN40_CMH_100094	SPIN-R	SPN31_CMH_100094	1989-03-15	1987-04-15	700	Male	Male

No linked origin record. These participants contribute nothing to the From origin study tabs.

Participant	Group
SPN40_CMH_90037	Not assigned

All links. Every SPINAPS participant and the origin records used, with how each link was found: form + number (the Shared Data form and the SPN40 number agree), form or number only, or override.

Participant	Group	Study	Origin ID	Found by
SPN40_CMH_0116	ASD-Impaired	SPIN-ASD	SPASD_CMP_0116	form + number
SPN40_CMH_0118	ASD-Impaired	SPIN-ASD	SPASD_CMP_0118	form + number
SPN40_CMH_0122	TDC	SPIN-ASD	SPASD_CMP_0122	form + number
SPN40_CMH_0135	TDC	SPIN-ASD	SPASD_CMP_0135	form + number
SPN40_CMH_0142	ASD-Impaired	SPIN-ASD	SPASD_CMP_0142	form + number
SPN40_CMH_0146	ASD-Impaired	SPIN-ASD	SPASD_CMP_0146	number
SPN40_CMH_0146	ASD-Impaired	SPIN-R	SPN31_CMH_100146	form
SPN40_CMH_0156/90102	TDC	SPIN-ASD	SPASD_CMP_0156	number
SPN40_CMH_0157	TDC	SPIN-ASD	SPASD_CMP_0157	form + number
SPN40_CMH_0158/90080	TDC	SPIN-ASD	SPASD_CMP_0158	form + number
SPN40_CMH_0159/90086	TDC	SPIN-ASD	SPASD_CMP_0159	form + number
SPN40_CMH_100002	ASD-Impaired	SPIN-R	SPN31_CMH_100002	form + number
SPN40_CMH_100003	ASD-Impaired	SPIN-ASD	SPASD_CMP_0003	form
SPN40_CMH_100003	ASD-Impaired	SPIN-R	SPN31_CMH_100003	form + number
SPN40_CMH_100006	ASD-Impaired	SPIN-R	SPN31_CMH_100006	form + number
SPN40_CMH_100012	ASD-Intact	SPIN-ASD	SPASD_CMP_0012	form
SPN40_CMH_100012	ASD-Intact	SPIN-R	SPN31_CMH_100012	form + number
SPN40_CMH_100020	ASD-Impaired	SPIN-ASD	SPASD_CMP_0020	form
SPN40_CMH_100020	ASD-Impaired	SPIN-R	SPN31_CMH_100020	form + number
SPN40_CMH_100029	ASD-Impaired	SPIN-ASD	SPASD_CMP_0029	form
SPN40_CMH_100029	ASD-Impaired	SPIN-R	SPN31_CMH_100029	form + number
SPN40_CMH_100035	ASD-Impaired	SPIN-R	SPN31_CMH_100035	form + number
SPN40_CMH_100036	ASD-Impaired	SPIN-R	SPN31_CMH_100036	form + number
SPN40_CMH_100047	ASD-Impaired	SPIN-R	SPN31_CMH_100047	form + number
SPN40_CMH_100056	ASD-Impaired	SPIN-R	SPN31_CMH_100056	form + number
SPN40_CMH_100060	ASD-Impaired	SPIN-ASD	SPASD_CMP_0060	form
SPN40_CMH_100060	ASD-Impaired	SPIN-R	SPN31_CMH_100060	form + number
SPN40_CMH_100068	ASD-Impaired	SPIN-R	SPN31_CMH_100068	form + number
SPN40_CMH_100070	ASD-Impaired	SPIN-ASD	SPASD_CMP_0070	form
SPN40_CMH_100070	ASD-Impaired	SPIN-R	SPN31_CMH_100070	form + number
SPN40_CMH_100091	ASD-Impaired	SPIN-R	SPN31_CMH_100091	form + number
SPN40_CMH_100094	TDC	SPIN-ASD	SPASD_CMP_0094	form
SPN40_CMH_100094	TDC	SPIN-R	SPN31_CMH_100094	form + number
SPN40_CMH_100104	Not assigned	SPIN-R	SPN31_CMH_100104	form + number
SPN40_CMH_100113	ASD-Impaired	SPIN-ASD	SPASD_CMP_0113	form
SPN40_CMH_100115	ASD-Impaired	SPIN-ASD	SPASD_CMP_0115	form
SPN40_CMH_100117	TDC	SPIN-R	SPN31_CMH_100117	form + number
SPN40_CMH_100119	TDC	SPIN-R	SPN31_CMH_100119	form + number
SPN40_CMH_100125	ASD-Impaired	SPIN-ASD	SPASD_CMP_0125	form
SPN40_CMH_100125	ASD-Impaired	SPIN-R	SPN31_CMH_100125	number
SPN40_CMH_100132	TDC	SPIN-R	SPN30_CMH_010158	form
SPN40_CMH_100133	ASD-Impaired	SPIN-ASD	SPASD_CMP_0133	form
SPN40_CMH_50001	TDC	SPIN-R	SPN30_CMH_050001	form + number
SPN40_CMH_50002	TDC	SPIN-R	SPN30_CMH_050002	form + number
SPN40_CMH_50004	TDC	SPIN-R	SPN30_CMH_050004	form + number
SPN40_CMH_50005	TDC	SPIN-R	SPN31_CMH_050005	form + number
SPN40_CMH_50006	TDC	SPIN-R	SPN31_CMH_050006	form + number
SPN40_CMH_50007	TDC	SPIN-R	SPN31_CMH_050007	form + number
SPN40_CMH_50008	TDC	SPIN-R	SPN31_CMH_050008	form + number
SPN40_CMH_50013/90091	TDC	SPIN-R	SPN30_CMH_050013	form + number
SPN40_CMH_50017/90105	TDC	SPIN-R	SPN30_CMH_050017	number
SPN40_CMH_60001	ASD-Impaired	SPIN-R	SPN31_CMH_060001	form + number
SPN40_CMH_60003	Not assigned	SPIN-R	SPN31_CMH_060003	form + number
SPN40_CMH_60004	Not assigned	SPIN-R	SPN31_CMH_060004	form + number

Shared Data form

Ticked as shared, not found. Assessments ticked on the Shared Data Availability checklist that none of the participant’s linked origin records contain. Either the assessment is in a study not linked here (e.g. TAY or SYNAPSIS), the link is wrong, or the tick is wrong.

Participant	Instrument	Records searched
SPN40_CMH_50006	BPRS	SPN31_CMH_050006
SPN40_CMH_60001	WASI-II	SPN31_CMH_060001
SPN40_CMH_60003	ADOS-2	SPN31_CMH_060003
SPN40_CMH_60003	MATRICS	SPN31_CMH_060003
SPN40_CMH_60003	WASI-II	SPN31_CMH_060003
SPN40_CMH_60004	BPRS	SPN31_CMH_060004
SPN40_CMH_60004	MATRICS	SPN31_CMH_060004
SPN40_CMH_60004	WASI-II	SPN31_CMH_060004
SPN40_CMH_100002	ADOS-2	SPN31_CMH_100002
SPN40_CMH_100002	Edinburgh Handedness	SPN31_CMH_100002
SPN40_CMH_100002	WASI-II	SPN31_CMH_100002
SPN40_CMH_100036	ADOS-2	SPN31_CMH_100036
SPN40_CMH_100036	WASI-II	SPN31_CMH_100036
SPN40_CMH_100047	ADOS-2	SPN31_CMH_100047
SPN40_CMH_100047	Edinburgh Handedness	SPN31_CMH_100047
SPN40_CMH_100047	WASI-II	SPN31_CMH_100047
SPN40_CMH_100056	ADOS-2	SPN31_CMH_100056
SPN40_CMH_100056	Edinburgh Handedness	SPN31_CMH_100056
SPN40_CMH_100056	WASI-II	SPN31_CMH_100056
SPN40_CMH_100091	ADOS-2	SPN31_CMH_100091
SPN40_CMH_100091	Edinburgh Handedness	SPN31_CMH_100091
SPN40_CMH_100091	WASI-II	SPN31_CMH_100091

Checklist vs origin records, by instrument. Found, not ticked usually means the checklist was not completed in full; it matters if the assessment was meant to be repeated in SPINAPS instead.

Instrument	Ticked and found	Found, not ticked	Ticked, not found
Parental education	5	40	0
ER-40	26	19	0
Edinburgh Handedness	18	15	4
MATRICS	27	15	2
ABAS-III	31	13	0
WASI-II	19	10	8
Birchwood SFS	36	9	0
RMET	38	7	0
AQ	40	5	0
TASIT-R	39	5	0
ADOS-2	12	3	6
BPRS	24	1	2

Dates and PET QC

Impossible dates. Dates of assessment in the future, PETs dated before the eligibility assessment, and PET QC dated before the PET.

Participant	Issue	Detail
SPN40_CMH_100006	PET QC dated before the PET	pet_doa = 2023-05-26, pet_qc_doa = 2022-06-19
SPN40_CMH_100056	PET before eligibility assessment	elg_doa = 2022-11-10, pet_doa = 2022-10-13
SPN40_CMH_100115	PET before eligibility assessment	elg_doa = 2022-11-21, pet_doa = 2022-11-17
SPN40_CMH_60004	Date in the future	demo_doa = 2026-11-26
SPN40_CMH_60004	Date in the future	npmed_doa = 2026-11-26

PET QC backlog. PETs whose Reconstructed PET Image QC form is still empty more than 30 days after the scan. Until QC is done they cannot count towards the targets.

Participant	Group	PET date	Days waiting
SPN40_CMH_50007	TDC	2025-05-09	516
SPN40_CMH_50002	TDC	2025-05-23	502
SPN40_CMH_0157	TDC	2025-06-10	484
SPN40_CMH_50008	TDC	2025-06-18	476
SPN40_CMH_0158/90080	TDC	2025-07-31	433
SPN40_CMH_0159/90086	TDC	2025-08-29	404
SPN40_CMH_50013/90091	TDC	2025-09-16	386
SPN40_CMH_60004	Not assigned	2025-12-03	308
SPN40_CMH_60003	Not assigned	2026-02-27	222
SPN40_CMH_0156/90102	TDC	2026-05-06	154
SPN40_CMH_50017/90105	TDC	2026-06-10	119

Values

Outside the valid range. Each field in config/score_ranges.csv against its valid range. These values are left out of every table and plot; REDCap missing-data codes (e.g. ASKU) are read as missing and listed for completeness.

Participant	Group	Field	Value	Issue
SPN40_CMH_0158/90080	TDC	BMI	10000	Outside 12-60
SPN40_CMH_100132	TDC	PET injected mass (ug)	4584	Outside 0-10

Specific activity. The PET form’s specific-activity fields have no units, and the values span several orders of magnitude. Values more than 10 times away from the field’s median are listed: probably a different unit (e.g. GBq/µmol vs mCi/µmol). These fields are not used in this report until the unit is agreed.

Participant	Field	Value	Field median
SPN40_CMH_100029	Specific activity at synthesis	5.630	4168
SPN40_CMH_100117	Specific activity at synthesis	7.310	4168
SPN40_CMH_100119	Specific activity at synthesis	10.390	4168
SPN40_CMH_100132	Specific activity at synthesis	1.292	4168
SPN40_CMH_100002	Specific activity at injection	174.500	3768
SPN40_CMH_100006	Specific activity at injection	214.300	3768
SPN40_CMH_100012	Specific activity at injection	68.200	3768
SPN40_CMH_100070	Specific activity at injection	197.640	3768
SPN40_CMH_100125	Specific activity at injection	85.800	3768

Eligibility

No group or eligibility. Participants with no group on the Eligibility Checklist, or not recorded as eligible. They are counted as Not assigned throughout.

Participant	Group	Eligible	Eligibility date	PET date	Withdrawn
SPN40_CMH_60003	Not assigned	Yes	2026-02-26	2026-02-27	No
SPN40_CMH_60004	Not assigned	Yes	2025-11-26	2025-12-03	No
SPN40_CMH_90037	Not assigned	Not recorded			No
SPN40_CMH_100104	Not assigned	Not recorded			Yes

Recorded subgroup differs from the checklist rule. From the Group Assignment Check, using origin-study scores.

Participant	Recorded group	Group by rule	Below cut-off
SPN40_CMH_100003	ASD-Impaired	ASD-Intact
SPN40_CMH_100012	ASD-Intact	ASD-Impaired	RMET
SPN40_CMH_60001	ASD-Impaired	ASD-Intact (incomplete scores)

TDC to confirm. Typically developing controls must have no DSM-5 disorder, except adjustment disorder, phobic disorder, or a single past major depressive episode at least two years ago and not currently treated. Listed: TDC with any lifetime diagnosis on their origin SCID, or a current psychotropic medication in SPINAPS.

Participant	Issue	Detail
SPN40_CMH_0135	SCID diagnosis (origin study, lifetime)	Major depressive disorder
SPN40_CMH_0156/90102	SCID diagnosis (origin study, lifetime)	Bulimia nervosa
SPN40_CMH_0157	SCID diagnosis (origin study, lifetime)	Major depressive disorder
SPN40_CMH_0135	Current psychotropic medication	SSRI: fluoxetine

SPINAPS Study Tracking

Hassan Abdulrasul

2026-10-07

Overview: progress towards the PET targets

Recruitment

Withdrawals

Descriptive Statistics

SPINAPS REDCap

From origin study

Distributions

Age

Sex

Gender

Education

IQ (origin study)

Data Sharing

Sources

Shared assessments

MRI

Age of shared assessments

Assessment Completion

SPINAPS REDCap

ASD-Impaired

ASD-Intact

TDC

Not assigned

From origin study

ASD-Impaired

ASD-Intact

TDC

Not assigned

Group Assignment Check

SPINAPS REDCap

From origin study

Structured Clinical Interview for DSM Disorders (SCID)

SPINAPS REDCap

Current

Lifetime

From origin study

Current

Lifetime

Clinical Scores

Autism-Spectrum Quotient (AQ)

SPINAPS REDCap

From origin study

ADOS-2

SPINAPS REDCap

From origin study

Brief Psychiatric Rating Scale (BPRS)

SPINAPS REDCap

From origin study

PHQ-9 and GAD-7

SPINAPS REDCap

From origin study

Cognition

IQ (WASI-II / WAIS-IV)

SPINAPS REDCap

From origin study

MATRICS Consensus Cognitive Battery

SPINAPS REDCap

From origin study

Reading the Mind in the Eyes Test (RMET)

SPINAPS REDCap

From origin study

The Awareness of Social Inference Test (TASIT-R)

SPINAPS REDCap

From origin study

Penn Emotion Recognition Test (ER-40)

SPINAPS REDCap

From origin study

Functioning

Birchwood Social Functioning Scale (SFS)

SPINAPS REDCap

From origin study

Adaptive Behavior Assessment System (ABAS-III)

SPINAPS REDCap

From origin study

PET Session

Safety

Adverse events