1 Project Summary

Goal was to determine which neuropsych measures to retain in the bedside/PPG. Two data sets were used: PPG and TabCAT PPG includes all PPG participants. TabCAT includes a subset of PPG participants as well as a larger sample of MAC participants with bedside and/or TabCAT.

2 Demographic Tables (PPG)

Sample by Baseline CDR Global
Variable	Overall	0	0.5	1	2+	Missing
Sample Size	1703	352	616	450	134	151
Age	69.7 (12.1)	65.4 (16.4)	71.7 (9.9)	70.8 (9.8)	68.4 (9.7)	69.5 (13.5)
Education	16.5 (5.4)	16.9 (5.2)	16.3 (2.9)	16.4 (6.4)	16.2 (7.9)	17.3 (7.6)
Total_visits (%)
1	1106 (64.9)	236 (67.0)	368 (59.7)	281 (62.4)	104 (77.6)	117 (77.5)
2	394 (23.1)	65 (18.5)	155 (25.2)	130 (28.9)	25 (18.7)	19 (12.6)
3	125 ( 7.3)	21 ( 6.0)	65 (10.6)	29 ( 6.4)	4 ( 3.0)	6 ( 4.0)
4	50 ( 2.9)	16 ( 4.5)	21 ( 3.4)	7 ( 1.6)	1 ( 0.7)	5 ( 3.3)
5+	28 ( 1.6)	14 ( 4.0)	7 ( 1.1)	3 ( 0.7)	0 ( 0.0)	4 ( 2.6)
Sex = 2 (%)	811 (47.6)	190 (54.0)	294 (47.7)	192 (42.7)	60 (44.8)	75 (49.7)
Syndrome/Diagnosis
AD or AD+	223 (13.1)	3 ( 0.9)	73 (11.9)	107 (23.8)	18 (13.4)	22 (14.6)
ALS	33 ( 1.9)	15 ( 4.3)	9 ( 1.5)	3 ( 0.7)	2 ( 1.5)	4 ( 2.6)
bvFTD or sbvFTD	100 ( 5.9)	2 ( 0.6)	27 ( 4.4)	41 ( 9.1)	24 (17.9)	6 ( 4.0)
CBD/CBS	106 ( 6.2)	14 ( 4.0)	52 ( 8.4)	28 ( 6.2)	4 ( 3.0)	8 ( 5.3)
CJD or RPD	5 ( 0.3)	0 ( 0.0)	0 ( 0.0)	2 ( 0.4)	3 ( 2.2)	0 ( 0.0)
CU or Asymptomatic	254 (14.9)	185 (52.6)	22 ( 3.6)	0 ( 0.0)	0 ( 0.0)	47 (31.1)
DLB or DLB+	16 ( 0.9)	0 ( 0.0)	7 ( 1.1)	6 ( 1.3)	2 ( 1.5)	1 ( 0.7)
FTD or FTLD	164 ( 9.6)	0 ( 0.0)	31 ( 5.0)	74 (16.4)	53 (39.6)	6 ( 4.0)
lvPPA	59 ( 3.5)	5 ( 1.4)	38 ( 6.2)	10 ( 2.2)	1 ( 0.7)	5 ( 3.3)
MCI	135 ( 7.9)	22 ( 6.2)	91 (14.8)	8 ( 1.8)	0 ( 0.0)	14 ( 9.3)
MSA	2 ( 0.1)	1 ( 0.3)	0 ( 0.0)	1 ( 0.2)	0 ( 0.0)	0 ( 0.0)
nvPPA	82 ( 4.8)	27 ( 7.7)	39 ( 6.3)	10 ( 2.2)	0 ( 0.0)	6 ( 4.0)
Other	77 ( 4.5)	21 ( 6.0)	30 ( 4.9)	16 ( 3.6)	5 ( 3.7)	5 ( 3.3)
PCA	34 ( 2.0)	1 ( 0.3)	17 ( 2.8)	12 ( 2.7)	2 ( 1.5)	2 ( 1.3)
PD	9 ( 0.5)	4 ( 1.1)	4 ( 0.6)	0 ( 0.0)	1 ( 0.7)	0 ( 0.0)
PPA unspecified	19 ( 1.1)	0 ( 0.0)	10 ( 1.6)	8 ( 1.8)	1 ( 0.7)	0 ( 0.0)
Primary Psych	42 ( 2.5)	9 ( 2.6)	20 ( 3.2)	11 ( 2.4)	0 ( 0.0)	2 ( 1.3)
PSP	99 ( 5.8)	5 ( 1.4)	40 ( 6.5)	43 ( 9.6)	5 ( 3.7)	6 ( 4.0)
svPPA	110 ( 6.5)	3 ( 0.9)	63 (10.2)	33 ( 7.3)	6 ( 4.5)	5 ( 3.3)
Unknown	134 ( 7.9)	35 ( 9.9)	43 ( 7.0)	37 ( 8.2)	7 ( 5.2)	12 ( 7.9)

3 Task Completion rates (PPG)

To examine patterns of missingness, we coded each task as completed or missing (yes vs. no) for each participant. Results are presented in a table and in plots. Because the table is dense, we recommend relying on the plots.

3.1 Table (PPG)

Sample by Baseline CDR Global
Variable	Overall	0	0.5	1	2+	Missing
Sample Size	1703	352	616	450	134	151
CDR Sum of Boxes = Yes (%)	1552 (91.1)	352 (100.0)	616 (100.0)	450 (100.0)	134 (100.0)	0 ( 0.0)
CVLT-II Short Trials 1–4 Sum = Yes (%)	471 (27.7)	136 ( 38.6)	165 ( 26.8)	112 ( 24.9)	35 ( 26.1)	23 (15.2)
CVLT-II Short Delayed Recall = Yes (%)	470 (27.6)	136 ( 38.6)	165 ( 26.8)	111 ( 24.7)	35 ( 26.1)	23 (15.2)
Benson Delayed Recall = Yes (%)	1448 (85.0)	334 ( 94.9)	557 ( 90.4)	390 ( 86.7)	107 ( 79.9)	60 (39.7)
Benson Copy = Yes (%)	1462 (85.8)	332 ( 94.3)	558 ( 90.6)	398 ( 88.4)	113 ( 84.3)	61 (40.4)
MoCA Total Score = Yes (%)	599 (35.2)	171 ( 48.6)	219 ( 35.6)	142 ( 31.6)	38 ( 28.4)	29 (19.2)
Trails A Seconds = Yes (%)	952 (55.9)	234 ( 66.5)	365 ( 59.3)	264 ( 58.7)	50 ( 37.3)	39 (25.8)
Trails B Seconds = Yes (%)	757 (44.5)	210 ( 59.7)	311 ( 50.5)	178 ( 39.6)	25 ( 18.7)	33 (21.9)
Animals = Yes (%)	1537 (90.3)	340 ( 96.6)	586 ( 95.1)	422 ( 93.8)	118 ( 88.1)	71 (47.0)
D Words Correct = Yes (%)	1478 (86.8)	338 ( 96.0)	567 ( 92.0)	399 ( 88.7)	112 ( 83.6)	62 (41.1)
Design Fluency Correct = Yes (%)	1347 (79.1)	327 ( 92.9)	538 ( 87.3)	340 ( 75.6)	91 ( 67.9)	51 (33.8)
Digit Backwards Total Correct = Yes (%)	508 (29.8)	57 ( 16.2)	223 ( 36.2)	169 ( 37.6)	45 ( 33.6)	14 ( 9.3)
Digit Forwards Total Correct = Yes (%)	515 (30.2)	58 ( 16.5)	225 ( 36.5)	172 ( 38.2)	46 ( 34.3)	14 ( 9.3)
Stroop Color Naming Correct = Yes (%)	384 (22.5)	140 ( 39.8)	139 ( 22.6)	72 ( 16.0)	17 ( 12.7)	16 (10.6)
Stroop Interference Naming Correct = Yes (%)	384 (22.5)	145 ( 41.2)	134 ( 21.8)	74 ( 16.4)	15 ( 11.2)	16 (10.6)
Modified Trails Time = Yes (%)	1325 (77.8)	326 ( 92.6)	539 ( 87.5)	330 ( 73.3)	77 ( 57.5)	53 (35.1)
Modified Trails Correct = Yes (%)	1327 (77.9)	326 ( 92.6)	539 ( 87.5)	331 ( 73.6)	78 ( 58.2)	53 (35.1)
Calculations = Yes (%)	1452 (85.3)	321 ( 91.2)	567 ( 92.0)	394 ( 87.6)	113 ( 84.3)	57 (37.7)
BNT Total Correct = Yes (%)	1494 (87.7)	329 ( 93.5)	562 ( 91.2)	417 ( 92.7)	121 ( 90.3)	65 (43.0)
WRAT Total = Yes (%)	341 (20.0)	117 ( 33.2)	122 ( 19.8)	65 ( 14.4)	22 ( 16.4)	15 ( 9.9)
Total Score Face Matching = Yes (%)	367 (21.6)	122 ( 34.7)	133 ( 21.6)	73 ( 16.2)	22 ( 16.4)	17 (11.3)
Total Score Affect Matching = Yes (%)	361 (21.2)	121 ( 34.4)	132 ( 21.4)	71 ( 15.8)	21 ( 15.7)	16 (10.6)

3.2 Bar Charts by CDR (PPG)

3.3 Bar Charts by Diagnosis (PPG)

4 Demographic Tables (TabCAT)

4.1 By Diagnosis

Sample by Baseline DX
Variable	Overall	AD or AD+	bvFTD or sbvFTD	CBD/CBS	CU or Asymptomatic	DLB or DLB+	FTD or FTLD	lvPPA	MCI	nvPPA	Other	PCA	PD	PPA unspecified	Primary Psych	PSP	svPPA	Unknown
Sample Size	2323	169	95	44	775	12	26	46	431	47	315	14	56	14	47	44	39	149
CDR Sbs (mean (SD))	1.8 (2.6)	5.3 (2.2)	6.2 (2.8)	2.5 (2.2)	0.0 (0.1)	5.2 (2.0)	6.0 (3.4)	3.6 (2.1)	1.6 (1.6)	1.3 (1.5)	1.7 (2.7)	4.6 (2.5)	0.7 (1.0)	3.5 (2.4)	1.6 (1.9)	4.7 (3.2)	4.4 (2.7)	1.3 (2.7)
Craft Paraphrased Immediate Recall (mean (SD))	12.8 (5.7)	6.6 (4.9)	10.3 (4.7)	10.0 (5.5)	16.8 (3.9)	10.7 (5.4)	10.0 (6.2)	6.1 (4.4)	11.8 (5.0)	12.7 (5.3)	13.4 (5.1)	7.6 (5.0)	14.1 (1.6)	7.6 (5.1)	14.2 (5.4)	12.8 (4.6)	6.8 (5.4)	13.2 (4.7)
Craft Verbatim Immediate Recall (mean (SD))	16.8 (8.7)	8.0 (6.2)	13.1 (7.1)	12.7 (7.1)	22.9 (6.9)	12.7 (7.6)	12.8 (9.2)	8.0 (6.0)	15.1 (7.6)	16.6 (8.2)	17.5 (7.6)	9.0 (7.4)	18.4 (3.9)	10.8 (6.3)	19.3 (8.3)	16.7 (7.7)	8.4 (7.5)	17.4 (6.8)
Craft Verbatim Delayed Recall (mean (SD))	14.1 (8.9)	4.4 (5.7)	10.0 (6.5)	11.6 (7.4)	20.6 (6.7)	12.0 (6.3)	9.5 (9.3)	7.4 (5.9)	11.5 (7.8)	14.4 (8.4)	15.1 (8.3)	5.9 (4.6)	15.6 (5.9)	8.7 (6.9)	16.0 (8.2)	13.2 (8.5)	6.5 (7.2)	14.5 (7.2)
Benson Delayed Recall (mean (SD))	9.6 (4.6)	3.5 (3.5)	6.8 (4.1)	8.7 (3.9)	12.5 (2.6)	6.0 (3.2)	6.9 (5.0)	7.6 (4.5)	8.8 (4.2)	11.0 (3.2)	11.0 (3.6)	2.0 (2.6)	11.0 (5.0)	6.5 (4.5)	11.6 (3.2)	9.8 (2.8)	7.3 (5.3)	11.4 (3.2)
Benson Copy (mean (SD))	14.5 (2.7)	12.2 (4.6)	14.4 (2.9)	12.3 (4.6)	15.4 (1.1)	13.4 (2.4)	14.1 (3.3)	14.0 (3.2)	14.7 (2.2)	14.6 (1.9)	14.9 (2.0)	4.6 (2.9)	15.4 (1.2)	13.7 (2.6)	15.0 (2.2)	13.3 (2.4)	15.0 (1.9)	15.1 (1.5)
Animals (mean (SD))	17.3 (7.6)	9.9 (5.8)	12.3 (7.1)	13.3 (6.4)	22.3 (6.0)	13.0 (7.9)	12.0 (8.1)	8.2 (4.8)	17.5 (5.9)	12.4 (6.6)	18.8 (6.4)	9.7 (4.9)	19.9 (3.8)	10.0 (7.3)	19.3 (5.3)	12.6 (6.1)	9.3 (5.2)	20.5 (7.7)
Vegetables (mean (SD))	11.6 (5.6)	6.1 (4.3)	7.7 (4.6)	9.1 (4.4)	15.1 (4.8)	7.7 (4.5)	9.0 (5.3)	5.1 (3.4)	11.3 (4.6)	10.0 (4.8)	12.8 (4.9)	8.0 (5.8)	14.2 (3.2)	6.8 (4.5)	13.1 (4.3)	8.5 (4.1)	5.6 (5.1)	13.2 (4.8)
Words (F) (mean (SD))	12.4 (5.5)	9.7 (4.8)	7.7 (4.8)	9.2 (4.9)	15.6 (4.5)	8.0 (2.8)	8.9 (5.7)	7.8 (4.4)	13.0 (5.1)	6.5 (3.6)	13.0 (4.7)	12.0 (6.6)	14.6 (4.8)	8.4 (8.1)	14.3 (4.1)	8.2 (4.6)	8.7 (4.1)	14.1 (5.5)
Words (L) (mean (SD))	11.8 (5.5)	8.8 (4.7)	7.8 (4.8)	8.8 (3.5)	14.8 (4.6)	10.1 (3.1)	8.3 (4.9)	7.9 (4.0)	12.3 (5.2)	6.3 (4.2)	12.3 (4.7)	10.9 (4.9)	13.1 (1.6)	6.6 (6.6)	13.7 (5.2)	7.3 (5.1)	7.7 (4.2)	13.1 (5.3)
Digit Backwards Total Correct (mean (SD))	5.9 (2.7)	3.9 (2.1)	4.6 (2.1)	4.5 (2.1)	7.5 (2.6)	5.4 (1.7)	5.3 (3.0)	3.2 (1.5)	5.6 (2.2)	4.0 (2.2)	6.3 (2.5)	4.2 (2.4)	6.0 (1.6)	3.1 (1.7)	6.9 (2.2)	3.6 (1.7)	5.9 (2.2)	6.6 (3.1)
Trails A Seconds (mean (SD))	43.3 (30.1)	69.1 (43.5)	47.2 (27.7)	65.3 (32.2)	29.9 (15.3)	68.1 (52.3)	49.2 (36.7)	66.0 (40.2)	43.4 (28.7)	51.7 (27.3)	41.5 (23.6)	126.5 (33.2)	38.9 (14.3)	62.0 (27.8)	28.2 (10.6)	72.9 (42.6)	45.7 (25.0)	41.3 (33.8)
Trails A Correct (mean (SD))	23.8 (1.5)	23.2 (2.9)	23.8 (1.6)	23.4 (3.1)	24.0 (0.0)	21.3 (7.2)	23.3 (3.3)	23.5 (3.1)	23.9 (0.8)	23.9 (0.5)	23.9 (1.2)	19.2 (6.5)	24.0 (0.0)	24.0 (0.0)	24.0 (0.0)	23.6 (2.0)	24.0 (0.0)	24.0 (0.0)
Trails B Seconds (mean (SD))	85.3 (114.8)	206.8 (131.0)	108.9 (128.2)	136.1 (137.7)	39.5 (63.7)	149.5 (144.1)	150.5 (140.5)	196.5 (135.3)	71.5 (104.3)	76.2 (109.6)	60.9 (94.2)	278.8 (76.5)	24.0 (0.0)	174.5 (144.1)	51.6 (83.9)	136.1 (137.7)	63.4 (98.0)	70.0 (103.9)
Trails B Correct (mean (SD))	23.1 (3.4)	20.1 (6.5)	22.7 (3.8)	22.0 (4.7)	24.0 (0.5)	24.0 (0.0)	21.5 (6.6)	18.5 (7.7)	23.4 (2.7)	22.9 (4.1)	23.5 (2.1)	11.2 (8.8)	24.0 (0.0)	21.0 (7.1)	23.9 (0.3)	19.6 (8.1)	23.5 (1.9)	23.6 (1.9)
Digit Forwards Total Correct (mean (SD))	7.4 (2.9)	5.6 (2.5)	6.1 (2.1)	5.6 (2.1)	8.8 (2.7)	6.6 (2.8)	8.1 (2.5)	3.9 (1.6)	7.1 (2.8)	4.9 (2.2)	7.7 (2.8)	7.4 (2.3)	7.4 (1.7)	4.8 (2.6)	7.7 (2.2)	5.3 (2.3)	6.7 (2.4)	7.7 (3.1)
MoCA Total Score (mean (SD))	22.5 (6.0)	15.3 (5.5)	19.3 (5.7)	19.9 (5.4)	26.5 (2.8)	17.9 (5.2)	19.2 (7.2)	12.7 (6.2)	22.3 (4.6)	21.8 (5.4)	23.9 (5.1)	15.2 (5.5)	23.5 (3.6)	14.5 (7.1)	25.4 (3.3)	20.7 (4.9)	16.6 (5.7)	25.8 (3.4)
MINT Total (mean (SD))	27.5 (6.1)	24.4 (6.9)	23.8 (7.7)	27.5 (4.3)	30.3 (2.3)	22.4 (10.3)	26.0 (7.3)	18.4 (8.8)	28.5 (3.7)	26.2 (6.7)	29.4 (2.8)	21.6 (6.1)	28.9 (3.0)	23.9 (7.9)	29.9 (2.3)	27.9 (4.7)	9.6 (9.8)	28.8 (3.6)
BHS Sum (mean (SD))	1.1 (1.6)	2.1 (1.7)	3.4 (1.6)	2.8 (2.0)	0.2 (0.5)	2.9 (3.1)	3.1 (1.9)	2.7 (1.7)	1.1 (1.3)	2.1 (1.2)	0.9 (1.5)	1.4 (1.0)	1.4 (1.7)	2.5 (1.8)	2.1 (2.0)	3.9 (1.6)	3.0 (1.3)	0.5 (0.8)
Fav. Total (mean (SD))	12.0 (6.9)	3.3 (4.3)	7.3 (6.6)	10.0 (6.7)	15.7 (5.3)	6.9 (5.1)	7.5 (7.2)	5.7 (4.5)	9.2 (6.1)	11.0 (6.8)	12.0 (6.2)	4.4 (4.9)	14.6 (6.3)	11.1 (9.5)	13.2 (5.9)	11.4 (4.8)	3.9 (4.5)	14.6 (6.4)
Fav. dprime (mean (SD))	2.1 (1.2)	0.7 (0.8)	1.2 (1.1)	1.9 (1.1)	2.6 (0.9)	1.3 (0.9)	1.6 (1.3)	1.1 (0.9)	1.6 (1.1)	2.1 (1.3)	2.1 (1.1)	1.0 (0.8)	2.6 (1.0)	1.9 (1.7)	2.4 (0.9)	2.0 (0.9)	1.2 (1.1)	2.5 (1.0)
Match Total (mean (SD))	40.8 (12.9)	23.1 (13.4)	32.9 (12.6)	30.9 (11.7)	48.3 (7.4)	24.0 (15.0)	35.9 (12.4)	25.6 (12.8)	37.9 (10.9)	36.4 (10.4)	41.4 (10.7)	12.0 (6.5)	45.4 (8.4)	30.8 (17.9)	46.5 (9.3)	28.3 (11.2)	39.2 (9.0)	44.8 (11.4)
CDR Global (%)
0	1078 (46.4)	0 ( 0.0)	0 ( 0.0)	12 (27.3)	775 (100.0)	0 ( 0.0)	1 ( 3.8)	1 ( 2.2)	83 (19.3)	25 (53.2)	103 (32.7)	0 ( 0.0)	32 (57.1)	0 ( 0.0)	16 (34.0)	6 (13.6)	2 ( 5.1)	22 (14.8)
0.5	706 (30.4)	46 (27.2)	22 (23.2)	21 (47.7)	0 ( 0.0)	4 (33.3)	8 (30.8)	28 (60.9)	303 (70.3)	17 (36.2)	156 (49.5)	7 (50.0)	22 (39.3)	9 (64.3)	22 (46.8)	12 (27.3)	19 (48.7)	10 ( 6.7)
1	289 (12.4)	101 (59.8)	48 (50.5)	10 (22.7)	0 ( 0.0)	8 (66.7)	11 (42.3)	13 (28.3)	18 ( 4.2)	5 (10.6)	26 ( 8.3)	5 (35.7)	0 ( 0.0)	4 (28.6)	4 ( 8.5)	19 (43.2)	14 (35.9)	3 ( 2.0)
2+	68 ( 2.9)	17 (10.1)	20 (21.1)	0 ( 0.0)	0 ( 0.0)	0 ( 0.0)	5 (19.2)	2 ( 4.3)	2 ( 0.5)	0 ( 0.0)	9 ( 2.9)	1 ( 7.1)	0 ( 0.0)	0 ( 0.0)	0 ( 0.0)	7 (15.9)	4 (10.3)	1 ( 0.7)
Missing	182 ( 7.8)	5 ( 3.0)	5 ( 5.3)	1 ( 2.3)	0 ( 0.0)	0 ( 0.0)	1 ( 3.8)	2 ( 4.3)	25 ( 5.8)	0 ( 0.0)	21 ( 6.7)	1 ( 7.1)	2 ( 3.6)	1 ( 7.1)	5 (10.6)	0 ( 0.0)	0 ( 0.0)	113 (75.8)

4.2 By CDR

Sample by Baseline DX
Variable	Overall	0	0.5	1	2+	Missing
Sample Size	2323	1078	706	289	68	182
CDR Sbs (mean (SD))	1.8 (2.6)	0.0 (0.1)	1.9 (1.2)	5.7 (1.3)	10.4 (1.9)	NaN (NA)
Craft Paraphrased Immediate Recall (mean (SD))	12.8 (5.7)	15.8 (4.6)	11.6 (5.2)	8.5 (5.4)	6.3 (5.5)	12.2 (5.2)
Craft Verbatim Immediate Recall (mean (SD))	16.8 (8.7)	21.4 (7.6)	15.0 (7.6)	10.7 (7.6)	8.0 (7.7)	15.6 (7.2)
Craft Verbatim Delayed Recall (mean (SD))	14.1 (8.9)	18.9 (7.7)	11.9 (7.8)	7.7 (7.5)	5.2 (6.8)	13.0 (7.4)
Benson Delayed Recall (mean (SD))	9.6 (4.6)	12.1 (2.9)	8.9 (4.3)	5.7 (4.4)	3.9 (4.2)	10.5 (3.7)
Benson Copy (mean (SD))	14.5 (2.7)	15.2 (1.7)	14.5 (2.6)	13.3 (3.7)	11.4 (5.1)	14.7 (2.0)
Animals (mean (SD))	17.3 (7.6)	21.1 (6.5)	16.5 (6.6)	10.7 (6.3)	9.2 (7.5)	18.7 (6.2)
Vegetables (mean (SD))	11.6 (5.6)	14.4 (4.9)	10.8 (4.9)	6.9 (4.4)	5.2 (4.2)	12.2 (4.8)
Words (F) (mean (SD))	12.4 (5.5)	14.7 (4.9)	11.9 (5.2)	9.3 (5.0)	6.0 (4.5)	13.1 (5.4)
Words (L) (mean (SD))	11.8 (5.5)	14.0 (4.9)	11.4 (5.3)	8.5 (4.6)	6.3 (4.0)	12.4 (4.9)
Digit Backwards Total Correct (mean (SD))	5.9 (2.7)	7.0 (2.7)	5.6 (2.4)	4.3 (2.3)	4.0 (2.2)	6.0 (2.5)
Trails A Seconds (mean (SD))	43.3 (30.1)	33.6 (19.6)	45.1 (30.3)	63.2 (39.7)	63.7 (33.4)	45.7 (34.0)
Trails A Correct (mean (SD))	23.8 (1.5)	24.0 (0.0)	23.8 (1.5)	23.3 (3.0)	24.0 (0.0)	23.6 (2.0)
Trails B Seconds (mean (SD))	85.3 (114.8)	44.4 (72.3)	87.0 (115.9)	154.8 (138.1)	213.4 (129.3)	104.7 (126.5)
Trails B Correct (mean (SD))	23.1 (3.4)	23.8 (1.6)	22.9 (3.7)	21.4 (5.8)	22.2 (5.3)	23.2 (2.8)
Digit Forwards Total Correct (mean (SD))	7.4 (2.9)	8.3 (2.8)	7.0 (2.8)	5.9 (2.7)	6.1 (2.5)	7.3 (3.0)
MoCA Total Score (mean (SD))	22.5 (6.0)	25.7 (3.6)	21.8 (5.3)	17.3 (6.2)	12.8 (7.2)	23.7 (4.5)
MINT Total (mean (SD))	27.5 (6.1)	29.9 (3.1)	27.1 (6.3)	23.9 (7.9)	21.1 (9.2)	28.1 (3.4)
BHS Sum (mean (SD))	1.1 (1.6)	0.4 (0.9)	1.4 (1.5)	2.7 (2.0)	3.0 (1.7)	0.6 (1.0)
Fav. Total (mean (SD))	12.0 (6.9)	14.7 (5.9)	9.8 (6.6)	5.6 (5.7)	5.0 (5.6)	13.3 (6.4)
Fav. dprime (mean (SD))	2.1 (1.2)	2.5 (1.0)	1.7 (1.2)	1.2 (1.0)	0.7 (1.0)	2.4 (1.0)
Match Total (mean (SD))	40.8 (12.9)	46.5 (9.0)	37.7 (11.7)	27.6 (14.0)	20.8 (13.8)	43.6 (10.6)
Diagnosis (%)
AD or AD+	169 ( 7.3)	0 ( 0.0)	46 ( 6.5)	101 (34.9)	17 (25.0)	5 ( 2.7)
bvFTD or sbvFTD	95 ( 4.1)	0 ( 0.0)	22 ( 3.1)	48 (16.6)	20 (29.4)	5 ( 2.7)
CBD/CBS	44 ( 1.9)	12 ( 1.1)	21 ( 3.0)	10 ( 3.5)	0 ( 0.0)	1 ( 0.5)
CU or Asymptomatic	775 (33.4)	775 (71.9)	0 ( 0.0)	0 ( 0.0)	0 ( 0.0)	0 ( 0.0)
DLB or DLB+	12 ( 0.5)	0 ( 0.0)	4 ( 0.6)	8 ( 2.8)	0 ( 0.0)	0 ( 0.0)
FTD or FTLD	26 ( 1.1)	1 ( 0.1)	8 ( 1.1)	11 ( 3.8)	5 ( 7.4)	1 ( 0.5)
lvPPA	46 ( 2.0)	1 ( 0.1)	28 ( 4.0)	13 ( 4.5)	2 ( 2.9)	2 ( 1.1)
MCI	431 (18.6)	83 ( 7.7)	303 (42.9)	18 ( 6.2)	2 ( 2.9)	25 (13.7)
nvPPA	47 ( 2.0)	25 ( 2.3)	17 ( 2.4)	5 ( 1.7)	0 ( 0.0)	0 ( 0.0)
Other	315 (13.6)	103 ( 9.6)	156 (22.1)	26 ( 9.0)	9 (13.2)	21 (11.5)
PCA	14 ( 0.6)	0 ( 0.0)	7 ( 1.0)	5 ( 1.7)	1 ( 1.5)	1 ( 0.5)
PD	56 ( 2.4)	32 ( 3.0)	22 ( 3.1)	0 ( 0.0)	0 ( 0.0)	2 ( 1.1)
PPA unspecified	14 ( 0.6)	0 ( 0.0)	9 ( 1.3)	4 ( 1.4)	0 ( 0.0)	1 ( 0.5)
Primary Psych	47 ( 2.0)	16 ( 1.5)	22 ( 3.1)	4 ( 1.4)	0 ( 0.0)	5 ( 2.7)
PSP	44 ( 1.9)	6 ( 0.6)	12 ( 1.7)	19 ( 6.6)	7 (10.3)	0 ( 0.0)
svPPA	39 ( 1.7)	2 ( 0.2)	19 ( 2.7)	14 ( 4.8)	4 ( 5.9)	0 ( 0.0)
Unknown	149 ( 6.4)	22 ( 2.0)	10 ( 1.4)	3 ( 1.0)	1 ( 1.5)	113 (62.1)

5 Task Completion rates (TabCAT)

Sample by Baseline CDR
Variable	Overall	0	0.5	1	2+	Missing
Sample Size	2323	1078	706	289	68	182
CDR Sbs (mean (SD))	1.8 (2.6)	0.0 (0.1)	1.9 (1.2)	5.7 (1.3)	10.4 (1.9)	NaN (NA)
Craft Paraphrased Immediate Recall = Yes (%)	1349 ( 58.1)	566 ( 52.5)	477 ( 67.6)	208 ( 72.0)	41 ( 60.3)	57 ( 31.3)
Craft Verbatim Immediate Recall = Yes (%)	1349 ( 58.1)	566 ( 52.5)	477 ( 67.6)	208 ( 72.0)	41 ( 60.3)	57 ( 31.3)
Craft Verbatim Delayed Recall = Yes (%)	1333 ( 57.4)	564 ( 52.3)	475 ( 67.3)	197 ( 68.2)	40 ( 58.8)	57 ( 31.3)
Benson Delayed Recall = Yes (%)	1428 ( 61.5)	584 ( 54.2)	513 ( 72.7)	233 ( 80.6)	47 ( 69.1)	51 ( 28.0)
Benson Copy = Yes (%)	1525 ( 65.6)	631 ( 58.5)	543 ( 76.9)	244 ( 84.4)	50 ( 73.5)	57 ( 31.3)
Animals = Yes (%)	1522 ( 65.5)	628 ( 58.3)	542 ( 76.8)	244 ( 84.4)	51 ( 75.0)	57 ( 31.3)
Vegetables = Yes (%)	1510 ( 65.0)	627 ( 58.2)	543 ( 76.9)	235 ( 81.3)	46 ( 67.6)	59 ( 32.4)
Words (F) = Yes (%)	1335 ( 57.5)	525 ( 48.7)	483 ( 68.4)	230 ( 79.6)	44 ( 64.7)	53 ( 29.1)
Words (L) = Yes (%)	1317 ( 56.7)	522 ( 48.4)	480 ( 68.0)	222 ( 76.8)	43 ( 63.2)	50 ( 27.5)
Digit Backwards Total Correct = Yes (%)	1453 ( 62.5)	621 ( 57.6)	502 ( 71.1)	228 ( 78.9)	47 ( 69.1)	55 ( 30.2)
Trails A Seconds = Yes (%)	1438 ( 61.9)	620 ( 57.5)	515 ( 72.9)	215 ( 74.4)	32 ( 47.1)	56 ( 30.8)
Trails A Correct = Yes (%)	1438 ( 61.9)	620 ( 57.5)	515 ( 72.9)	215 ( 74.4)	32 ( 47.1)	56 ( 30.8)
Trails B Seconds = Yes (%)	1549 ( 66.7)	636 ( 59.0)	548 ( 77.6)	249 ( 86.2)	51 ( 75.0)	65 ( 35.7)
Trails B Correct = Yes (%)	1305 ( 56.2)	600 ( 55.7)	471 ( 66.7)	162 ( 56.1)	20 ( 29.4)	52 ( 28.6)
Digit Forwards Total Correct = Yes (%)	1453 ( 62.5)	621 ( 57.6)	502 ( 71.1)	228 ( 78.9)	47 ( 69.1)	55 ( 30.2)
MoCA Total Score = Yes (%)	1498 ( 64.5)	628 ( 58.3)	530 ( 75.1)	232 ( 80.3)	48 ( 70.6)	60 ( 33.0)
MINT Total = Yes (%)	1299 ( 55.9)	525 ( 48.7)	471 ( 66.7)	207 ( 71.6)	44 ( 64.7)	52 ( 28.6)
BHS Sum = Yes (%)	2323 (100.0)	1078 (100.0)	706 (100.0)	289 (100.0)	68 (100.0)	182 (100.0)
Fav. Total = Yes (%)	1931 ( 83.1)	937 ( 86.9)	597 ( 84.6)	201 ( 69.6)	37 ( 54.4)	159 ( 87.4)
Fav. dprime = Yes (%)	1621 ( 69.8)	752 ( 69.8)	524 ( 74.2)	168 ( 58.1)	32 ( 47.1)	145 ( 79.7)
Match Total = Yes (%)	2158 ( 92.9)	1033 ( 95.8)	649 ( 91.9)	253 ( 87.5)	52 ( 76.5)	171 ( 94.0)

5.1 Table (TabCAT)

Sample by Baseline Diagnosis
Variable	Overall	AD or AD+	bvFTD or sbvFTD	CBD/CBS	CU or Asymptomatic	DLB or DLB+	FTD or FTLD	lvPPA	MCI	nvPPA	Other	PCA	PD	PPA unspecified	Primary Psych	PSP	svPPA	Unknown
Sample Size	2323	169	95	44	775	12	26	46	431	47	315	14	56	14	47	44	39	149
CDR Sbs (mean (SD))	1.8 (2.6)	5.3 (2.2)	6.2 (2.8)	2.5 (2.2)	0.0 (0.1)	5.2 (2.0)	6.0 (3.4)	3.6 (2.1)	1.6 (1.6)	1.3 (1.5)	1.7 (2.7)	4.6 (2.5)	0.7 (1.0)	3.5 (2.4)	1.6 (1.9)	4.7 (3.2)	4.4 (2.7)	1.3 (2.7)
Craft Paraphrased Immediate Recall = Yes (%)	1349 ( 58.1)	110 ( 65.1)	70 ( 73.7)	32 ( 72.7)	392 ( 50.6)	7 ( 58.3)	24 ( 92.3)	31 ( 67.4)	297 ( 68.9)	32 ( 68.1)	185 ( 58.7)	8 ( 57.1)	8 ( 14.3)	9 ( 64.3)	39 ( 83.0)	29 ( 65.9)	32 ( 82.1)	44 ( 29.5)
Craft Verbatim Immediate Recall = Yes (%)	1349 ( 58.1)	110 ( 65.1)	70 ( 73.7)	32 ( 72.7)	392 ( 50.6)	7 ( 58.3)	24 ( 92.3)	31 ( 67.4)	297 ( 68.9)	32 ( 68.1)	185 ( 58.7)	8 ( 57.1)	8 ( 14.3)	9 ( 64.3)	39 ( 83.0)	29 ( 65.9)	32 ( 82.1)	44 ( 29.5)
Craft Verbatim Delayed Recall = Yes (%)	1333 ( 57.4)	104 ( 61.5)	69 ( 72.6)	31 ( 70.5)	391 ( 50.5)	6 ( 50.0)	24 ( 92.3)	31 ( 67.4)	296 ( 68.7)	32 ( 68.1)	184 ( 58.4)	8 ( 57.1)	8 ( 14.3)	9 ( 64.3)	38 ( 80.9)	28 ( 63.6)	30 ( 76.9)	44 ( 29.5)
Benson Delayed Recall = Yes (%)	1428 ( 61.5)	135 ( 79.9)	79 ( 83.2)	30 ( 68.2)	421 ( 54.3)	9 ( 75.0)	23 ( 88.5)	39 ( 84.8)	329 ( 76.3)	37 ( 78.7)	149 ( 47.3)	12 ( 85.7)	8 ( 14.3)	11 ( 78.6)	39 ( 83.0)	31 ( 70.5)	35 ( 89.7)	41 ( 27.5)
Benson Copy = Yes (%)	1525 ( 65.6)	138 ( 81.7)	80 ( 84.2)	30 ( 68.2)	438 ( 56.5)	9 ( 75.0)	23 ( 88.5)	39 ( 84.8)	341 ( 79.1)	38 ( 80.9)	206 ( 65.4)	13 ( 92.9)	8 ( 14.3)	11 ( 78.6)	40 ( 85.1)	31 ( 70.5)	36 ( 92.3)	44 ( 29.5)
Animals = Yes (%)	1522 ( 65.5)	141 ( 83.4)	79 ( 83.2)	28 ( 63.6)	440 ( 56.8)	9 ( 75.0)	24 ( 92.3)	39 ( 84.8)	342 ( 79.4)	34 ( 72.3)	206 ( 65.4)	13 ( 92.9)	8 ( 14.3)	11 ( 78.6)	40 ( 85.1)	30 ( 68.2)	34 ( 87.2)	44 ( 29.5)
Vegetables = Yes (%)	1510 ( 65.0)	139 ( 82.2)	75 ( 78.9)	34 ( 77.3)	440 ( 56.8)	9 ( 75.0)	23 ( 88.5)	34 ( 73.9)	340 ( 78.9)	33 ( 70.2)	204 ( 64.8)	13 ( 92.9)	8 ( 14.3)	11 ( 78.6)	40 ( 85.1)	31 ( 70.5)	31 ( 79.5)	45 ( 30.2)
Words (F) = Yes (%)	1335 ( 57.5)	134 ( 79.3)	76 ( 80.0)	34 ( 77.3)	378 ( 48.8)	8 ( 66.7)	24 ( 92.3)	38 ( 82.6)	305 ( 70.8)	34 ( 72.3)	133 ( 42.2)	11 ( 78.6)	8 ( 14.3)	9 ( 64.3)	39 ( 83.0)	32 ( 72.7)	32 ( 82.1)	40 ( 26.8)
Words (L) = Yes (%)	1317 ( 56.7)	129 ( 76.3)	75 ( 78.9)	31 ( 70.5)	379 ( 48.9)	7 ( 58.3)	23 ( 88.5)	38 ( 82.6)	304 ( 70.5)	33 ( 70.2)	133 ( 42.2)	10 ( 71.4)	8 ( 14.3)	9 ( 64.3)	39 ( 83.0)	29 ( 65.9)	31 ( 79.5)	39 ( 26.2)
Digit Backwards Total Correct = Yes (%)	1453 ( 62.5)	134 ( 79.3)	69 ( 72.6)	26 ( 59.1)	436 ( 56.3)	8 ( 66.7)	20 ( 76.9)	36 ( 78.3)	328 ( 76.1)	33 ( 70.2)	202 ( 64.1)	13 ( 92.9)	8 ( 14.3)	10 ( 71.4)	35 ( 74.5)	24 ( 54.5)	29 ( 74.4)	42 ( 28.2)
Trails A Seconds = Yes (%)	1438 ( 61.9)	108 ( 63.9)	72 ( 75.8)	30 ( 68.2)	432 ( 55.7)	7 ( 58.3)	21 ( 80.8)	34 ( 73.9)	325 ( 75.4)	36 ( 76.6)	201 ( 63.8)	6 ( 42.9)	8 ( 14.3)	11 ( 78.6)	38 ( 80.9)	30 ( 68.2)	34 ( 87.2)	45 ( 30.2)
Trails A Correct = Yes (%)	1438 ( 61.9)	108 ( 63.9)	72 ( 75.8)	30 ( 68.2)	432 ( 55.7)	7 ( 58.3)	21 ( 80.8)	34 ( 73.9)	325 ( 75.4)	36 ( 76.6)	201 ( 63.8)	6 ( 42.9)	8 ( 14.3)	11 ( 78.6)	38 ( 80.9)	30 ( 68.2)	34 ( 87.2)	45 ( 30.2)
Trails B Seconds = Yes (%)	1549 ( 66.7)	151 ( 89.3)	78 ( 82.1)	32 ( 72.7)	444 ( 57.3)	11 ( 91.7)	24 ( 92.3)	40 ( 87.0)	343 ( 79.6)	37 ( 78.7)	202 ( 64.1)	13 ( 92.9)	8 ( 14.3)	11 ( 78.6)	40 ( 85.1)	32 ( 72.7)	35 ( 89.7)	48 ( 32.2)
Trails B Correct = Yes (%)	1305 ( 56.2)	74 ( 43.8)	63 ( 66.3)	24 ( 54.5)	422 ( 54.5)	6 ( 50.0)	15 ( 57.7)	25 ( 54.3)	300 ( 69.6)	33 ( 70.2)	188 ( 59.7)	4 ( 28.6)	8 ( 14.3)	7 ( 50.0)	37 ( 78.7)	25 ( 56.8)	32 ( 82.1)	42 ( 28.2)
Digit Forwards Total Correct = Yes (%)	1453 ( 62.5)	135 ( 79.9)	69 ( 72.6)	26 ( 59.1)	436 ( 56.3)	8 ( 66.7)	20 ( 76.9)	36 ( 78.3)	328 ( 76.1)	32 ( 68.1)	202 ( 64.1)	13 ( 92.9)	8 ( 14.3)	10 ( 71.4)	35 ( 74.5)	24 ( 54.5)	29 ( 74.4)	42 ( 28.2)
MoCA Total Score = Yes (%)	1498 ( 64.5)	130 ( 76.9)	76 ( 80.0)	30 ( 68.2)	439 ( 56.6)	10 ( 83.3)	23 ( 88.5)	39 ( 84.8)	335 ( 77.7)	35 ( 74.5)	204 ( 64.8)	9 ( 64.3)	8 ( 14.3)	11 ( 78.6)	40 ( 85.1)	31 ( 70.5)	35 ( 89.7)	43 ( 28.9)
MINT Total = Yes (%)	1299 ( 55.9)	120 ( 71.0)	76 ( 80.0)	33 ( 75.0)	379 ( 48.9)	7 ( 58.3)	24 ( 92.3)	37 ( 80.4)	299 ( 69.4)	36 ( 76.6)	129 ( 41.0)	5 ( 35.7)	8 ( 14.3)	9 ( 64.3)	39 ( 83.0)	28 ( 63.6)	30 ( 76.9)	40 ( 26.8)
BHS Sum = Yes (%)	2323 (100.0)	169 (100.0)	95 (100.0)	44 (100.0)	775 (100.0)	12 (100.0)	26 (100.0)	46 (100.0)	431 (100.0)	47 (100.0)	315 (100.0)	14 (100.0)	56 (100.0)	14 (100.0)	47 (100.0)	44 (100.0)	39 (100.0)	149 (100.0)
Fav. Total = Yes (%)	1931 ( 83.1)	120 ( 71.0)	59 ( 62.1)	38 ( 86.4)	688 ( 88.8)	10 ( 83.3)	23 ( 88.5)	28 ( 60.9)	375 ( 87.0)	40 ( 85.1)	246 ( 78.1)	12 ( 85.7)	53 ( 94.6)	8 ( 57.1)	35 ( 74.5)	39 ( 88.6)	27 ( 69.2)	130 ( 87.2)
Fav. dprime = Yes (%)	1621 ( 69.8)	102 ( 60.4)	53 ( 55.8)	26 ( 59.1)	544 ( 70.2)	8 ( 66.7)	15 ( 57.7)	24 ( 52.2)	329 ( 76.3)	29 ( 61.7)	236 ( 74.9)	10 ( 71.4)	34 ( 60.7)	8 ( 57.1)	35 ( 74.5)	25 ( 56.8)	19 ( 48.7)	124 ( 83.2)
Match Total = Yes (%)	2158 ( 92.9)	152 ( 89.9)	80 ( 84.2)	39 ( 88.6)	758 ( 97.8)	9 ( 75.0)	23 ( 88.5)	39 ( 84.8)	411 ( 95.4)	41 ( 87.2)	266 ( 84.4)	11 ( 78.6)	55 ( 98.2)	13 ( 92.9)	45 ( 95.7)	41 ( 93.2)	38 ( 97.4)	137 ( 91.9)

5.2 Bar Chart by CDR (TabCAT)

5.3 Bar Chart by Diagnosis

6 Floor and Ceiling (PPG)

6.1 Table and plots

For each task, we first present a table of floor and ceiling effects by CDR Global score, followed by plots. The plots are easier to interpret; the table is provided for readers who want the raw numbers.

In each plot, the y axis shows the percentage of data and the x axis shows the visit. Symbols indicate the following:

Filled circles: scores between the floor and ceiling Open squares: scores at the ceiling for that task “X”s: scores at the floor for that task

CDR Sum of Boxes is included for completeness only and should not be interpreted. On the Trails tasks, lower scores (faster times) indicate better performance, so floor and ceiling are reversed: participants at the “ceiling” were unable to complete the task.

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	352	49	303
0	2	106	13	93
0	3	48	4	44
0	4	29	3	26
0	5	12	1	11
0.5	1	616	616	0
0.5	2	174	174	0
0.5	3	51	51	0
0.5	4	19	19	0
0.5	5	6	6	0
1	1	450	450	0
1	2	179	179	0
1	3	58	58	0
1	4	12	12	0
1	5	5	5	0
2	1	123	123	0
2	2	101	101	0
2	3	33	33	0
2	4	8	8	0
2	5	4	4	0
3	1	11	11	0
3	2	8	8	0
3	3	3	3	0
3	4	2	2	0
3	5	1	1	0
Missing	1	0	0	0
Missing	2	0	0	0
Missing	3	0	0	0
Missing	4	0	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	136	135	1	0
0	2	44	42	2	0
0	3	25	23	2	0
0	4	17	16	1	0
0	5	4	3	1	0
0.5	1	165	165	0	0
0.5	2	50	50	0	0
0.5	3	17	17	0	0
0.5	4	5	5	0	0
0.5	5	2	2	0	0
1	1	112	111	0	1
1	2	53	51	0	2
1	3	19	19	0	0
1	4	2	2	0	0
1	5	3	3	0	0
2	1	32	32	0	0
2	2	29	29	0	0
2	3	9	9	0	0
2	4	3	3	0	0
2	5	3	3	0	0
3	1	3	3	0	0
3	2	4	4	0	0
3	3	1	1	0	0
3	4	1	1	0	0
3	5	1	1	0	0
Missing	1	23	23	0	0
Missing	2	10	10	0	0
Missing	3	0	0	0	0
Missing	4	3	3	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	136	84	51	1
0	2	44	22	22	0
0	3	25	13	12	0
0	4	17	3	13	1
0	5	4	0	4	0
0.5	1	165	149	12	4
0.5	2	50	36	10	4
0.5	3	17	10	6	1
0.5	4	5	1	4	0
0.5	5	2	1	1	0
1	1	111	84	7	20
1	2	53	41	1	11
1	3	19	12	2	5
1	4	2	1	0	1
1	5	3	1	0	2
2	1	32	19	0	13
2	2	29	18	1	10
2	3	8	7	0	1
2	4	3	2	0	1
2	5	3	2	0	1
3	1	3	2	0	1
3	2	4	3	0	1
3	3	1	0	0	1
3	4	1	0	0	1
3	5	1	1	0	0
Missing	1	23	19	4	0
Missing	2	10	8	2	0
Missing	3	0	0	0	0
Missing	4	3	2	1	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	334	326	6	2
0	2	100	98	2	0
0	3	47	46	1	0
0	4	28	28	0	0
0	5	11	11	0	0
0.5	1	557	526	1	30
0.5	2	157	145	1	11
0.5	3	47	44	1	2
0.5	4	17	17	0	0
0.5	5	6	6	0	0
1	1	390	307	1	82
1	2	165	128	0	37
1	3	53	38	0	15
1	4	11	9	1	1
1	5	4	4	0	0
2	1	100	70	0	30
2	2	83	50	0	33
2	3	33	19	0	14
2	4	6	4	0	2
2	5	3	2	0	1
3	1	7	7	0	0
3	2	8	4	0	4
3	3	1	1	0	0
3	4	1	0	0	1
3	5	1	1	0	0
Missing	1	60	56	1	3
Missing	2	19	19	0	0
Missing	3	7	6	1	0
Missing	4	7	7	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	332	295	36	1
0	2	101	93	8	0
0	3	47	46	1	0
0	4	28	27	1	0
0	5	11	10	1	0
0.5	1	558	525	31	2
0.5	2	158	140	15	3
0.5	3	48	41	6	1
0.5	4	17	16	0	1
0.5	5	6	6	0	0
1	1	398	368	19	11
1	2	168	148	11	9
1	3	53	43	7	3
1	4	11	8	3	0
1	5	5	5	0	0
2	1	105	95	4	6
2	2	84	74	3	7
2	3	33	27	3	3
2	4	6	6	0	0
2	5	3	3	0	0
3	1	8	8	0	0
3	2	8	7	0	1
3	3	1	1	0	0
3	4	2	2	0	0
3	5	1	1	0	0
Missing	1	61	54	7	0
Missing	2	19	17	2	0
Missing	3	7	6	1	0
Missing	4	7	7	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	171	150	21	0
0	2	75	59	16	0
0	3	39	32	7	0
0	4	23	16	7	0
0	5	11	6	5	0
0.5	1	219	213	6	0
0.5	2	66	63	3	0
0.5	3	21	19	2	0
0.5	4	11	11	0	0
0.5	5	3	3	0	0
1	1	142	142	0	0
1	2	40	39	0	1
1	3	11	11	0	0
1	4	3	3	0	0
1	5	0	0	0	0
2	1	33	33	0	0
2	2	23	23	0	0
2	3	10	10	0	0
2	4	2	2	0	0
2	5	1	1	0	0
3	1	5	5	0	0
3	2	2	2	0	0
3	3	0	0	0	0
3	4	0	0	0	0
3	5	0	0	0	0
Missing	1	29	29	0	0
Missing	2	11	10	1	0
Missing	3	4	4	0	0
Missing	4	4	3	1	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	234	233	1
0	2	84	84	0
0	3	41	40	1
0	4	26	26	0
0	5	11	11	0
0.5	1	365	348	17
0.5	2	107	102	5
0.5	3	30	29	1
0.5	4	13	12	1
0.5	5	4	4	0
1	1	264	233	31
1	2	88	78	10
1	3	25	21	4
1	4	7	6	1
1	5	3	3	0
2	1	47	37	10
2	2	38	28	10
2	3	15	13	2
2	4	5	5	0
2	5	3	3	0
3	1	3	2	1
3	2	4	4	0
3	3	1	1	0
3	4	0	0	0
3	5	1	1	0
Missing	1	39	37	2
Missing	2	13	13	0
Missing	3	4	4	0
Missing	4	4	4	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	225	224	1
0	2	84	84	0
0	3	39	39	0
0	4	26	26	0
0	5	11	11	0
0.5	1	334	284	50
0.5	2	98	81	17
0.5	3	30	24	6
0.5	4	13	10	3
0.5	5	4	4	0
1	1	209	140	69
1	2	66	53	13
1	3	21	17	4
1	4	6	6	0
1	5	3	2	1
2	1	28	15	13
2	2	20	14	6
2	3	9	6	3
2	4	4	3	1
2	5	3	1	2
3	1	1	0	1
3	2	2	1	1
3	3	0	0	0
3	4	0	0	0
3	5	0	0	0
Missing	1	35	31	4
Missing	2	13	13	0
Missing	3	4	4	0
Missing	4	4	4	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	340	340	0
0	2	105	105	0
0	3	46	46	0
0	4	28	28	0
0	5	11	11	0
0.5	1	586	582	4
0.5	2	162	162	0
0.5	3	47	47	0
0.5	4	17	16	1
0.5	5	6	6	0
1	1	422	417	5
1	2	166	161	5
1	3	52	48	4
1	4	10	9	1
1	5	4	3	1
2	1	109	102	7
2	2	91	84	7
2	3	32	28	4
2	4	6	5	1
2	5	4	4	0
3	1	9	6	3
3	2	8	8	0
3	3	2	2	0
3	4	1	1	0
3	5	1	1	0
Missing	1	71	70	1
Missing	2	21	21	0
Missing	3	7	7	0
Missing	4	7	7	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	338	337	1
0	2	103	103	0
0	3	47	47	0
0	4	28	28	0
0	5	11	11	0
0.5	1	567	560	7
0.5	2	159	157	2
0.5	3	47	47	0
0.5	4	17	16	1
0.5	5	6	6	0
1	1	399	393	6
1	2	164	159	5
1	3	50	47	3
1	4	10	10	0
1	5	4	4	0
2	1	103	97	6
2	2	84	74	10
2	3	32	28	4
2	4	7	7	0
2	5	4	4	0
3	1	9	5	4
3	2	8	8	0
3	3	2	1	1
3	4	1	1	0
3	5	1	1	0
Missing	1	62	62	0
Missing	2	19	19	0
Missing	3	7	7	0
Missing	4	7	7	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	327	326	1
0	2	100	100	0
0	3	46	46	0
0	4	27	27	0
0	5	11	11	0
0.5	1	538	533	5
0.5	2	147	146	1
0.5	3	43	42	1
0.5	4	16	16	0
0.5	5	5	5	0
1	1	340	326	14
1	2	133	128	5
1	3	42	41	1
1	4	9	9	0
1	5	5	5	0
2	1	86	76	10
2	2	71	57	14
2	3	20	16	4
2	4	5	5	0
2	5	4	4	0
3	1	5	5	0
3	2	5	5	0
3	3	1	1	0
3	4	1	0	1
3	5	1	1	0
Missing	1	51	50	1
Missing	2	16	16	0
Missing	3	4	4	0
Missing	4	7	7	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	57	57	0
0	2	11	11	0
0	3	2	2	0
0	4	3	3	0
0	5	1	1	0
0.5	1	223	220	3
0.5	2	60	57	3
0.5	3	15	15	0
0.5	4	5	5	0
0.5	5	3	3	0
1	1	169	160	9
1	2	69	69	0
1	3	18	15	3
1	4	7	7	0
1	5	2	1	1
2	1	43	39	4
2	2	35	28	7
2	3	11	9	2
2	4	4	3	1
2	5	1	1	0
3	1	2	2	0
3	2	3	3	0
3	3	1	1	0
3	4	0	0	0
3	5	1	1	0
Missing	1	14	14	0
Missing	2	2	2	0
Missing	3	0	0	0
Missing	4	0	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	58	58	0
0	2	11	11	0
0	3	2	2	0
0	4	3	3	0
0	5	1	1	0
0.5	1	225	223	2
0.5	2	60	59	1
0.5	3	15	14	1
0.5	4	5	5	0
0.5	5	3	3	0
1	1	172	167	5
1	2	70	70	0
1	3	18	18	0
1	4	7	7	0
1	5	2	1	1
2	1	44	44	0
2	2	38	38	0
2	3	11	11	0
2	4	4	3	1
2	5	1	1	0
3	1	2	2	0
3	2	3	3	0
3	3	1	1	0
3	4	0	0	0
3	5	1	1	0
Missing	1	14	13	1
Missing	2	2	2	0
Missing	3	0	0	0
Missing	4	0	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	140	140	0	0
0	2	44	44	0	0
0	3	24	24	0	0
0	4	17	17	0	0
0	5	3	3	0	0
0.5	1	139	139	0	0
0.5	2	43	43	0	0
0.5	3	18	18	0	0
0.5	4	6	6	0	0
0.5	5	2	2	0	0
1	1	72	71	1	0
1	2	40	40	0	0
1	3	16	16	0	0
1	4	2	2	0	0
1	5	1	1	0	0
2	1	17	17	0	0
2	2	12	11	0	1
2	3	6	6	0	0
2	4	3	3	0	0
2	5	3	3	0	0
3	1	0	0	0	0
3	2	3	3	0	0
3	3	0	0	0	0
3	4	0	0	0	0
3	5	1	1	0	0
Missing	1	16	16	0	0
Missing	2	6	6	0	0
Missing	3	0	0	0	0
Missing	4	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	145	145	0
0	2	44	44	0
0	3	25	25	0
0	4	17	17	0
0	5	3	3	0
0.5	1	134	134	0
0.5	2	42	42	0
0.5	3	18	18	0
0.5	4	6	6	0
0.5	5	2	2	0
1	1	74	73	1
1	2	37	36	1
1	3	15	15	0
1	4	2	2	0
1	5	1	1	0
2	1	15	15	0
2	2	11	9	2
2	3	6	6	0
2	4	3	3	0
2	5	3	3	0
3	1	0	0	0
3	2	2	2	0
3	3	0	0	0
3	4	0	0	0
3	5	1	1	0
Missing	1	16	16	0
Missing	2	6	6	0
Missing	3	0	0	0
Missing	4	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	326	318	8
0	2	100	100	0
0	3	47	47	0
0	4	28	28	0
0	5	11	11	0
0.5	1	539	425	114
0.5	2	157	129	28
0.5	3	44	37	7
0.5	4	16	12	4
0.5	5	5	5	0
1	1	330	210	120
1	2	144	87	57
1	3	44	27	17
1	4	10	6	4
1	5	5	4	1
2	1	73	31	42
2	2	60	21	39
2	3	18	7	11
2	4	5	4	1
2	5	3	2	1
3	1	4	0	4
3	2	6	4	2
3	3	1	0	1
3	4	1	0	1
3	5	1	1	0
Missing	1	53	47	6
Missing	2	18	14	4
Missing	3	7	7	0
Missing	4	7	7	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	326	11	310	5
0	2	100	0	100	0
0	3	47	0	46	1
0	4	28	1	27	0
0	5	11	0	11	0
0.5	1	539	108	425	6
0.5	2	157	29	127	1
0.5	3	46	7	39	0
0.5	4	16	4	12	0
0.5	5	5	0	5	0
1	1	331	122	203	6
1	2	144	57	86	1
1	3	44	16	27	1
1	4	10	4	6	0
1	5	5	1	4	0
2	1	74	40	32	2
2	2	60	38	21	1
2	3	18	12	6	0
2	4	5	1	4	0
2	5	3	1	2	0
3	1	4	4	0	0
3	2	6	2	4	0
3	3	1	1	0	0
3	4	1	1	0	0
3	5	1	0	1	0
Missing	1	53	6	46	1
Missing	2	18	4	14	0
Missing	3	7	0	7	0
Missing	4	7	0	7	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	321	101	220	0
0	2	101	27	74	0
0	3	47	16	31	0
0	4	28	11	17	0
0	5	11	4	7	0
0.5	1	567	297	262	8
0.5	2	161	97	64	0
0.5	3	50	27	23	0
0.5	4	17	12	5	0
0.5	5	6	2	4	0
1	1	394	261	118	15
1	2	165	115	41	9
1	3	57	37	15	5
1	4	11	7	4	0
1	5	5	4	1	0
2	1	104	87	13	4
2	2	85	56	13	16
2	3	33	19	4	10
2	4	7	4	3	0
2	5	4	3	1	0
3	1	9	8	0	1
3	2	6	6	0	0
3	3	2	2	0	0
3	4	1	1	0	0
3	5	1	0	1	0
Missing	1	57	24	32	1
Missing	2	19	9	10	0
Missing	3	7	1	6	0
Missing	4	7	1	6	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	329	328	1	0
0	2	97	97	0	0
0	3	45	44	0	1
0	4	26	26	0	0
0	5	10	10	0	0
0.5	1	562	558	0	4
0.5	2	164	163	0	1
0.5	3	42	41	0	1
0.5	4	17	16	0	1
0.5	5	5	5	0	0
1	1	417	413	1	3
1	2	170	163	0	7
1	3	53	46	0	7
1	4	11	11	0	0
1	5	5	4	0	1
2	1	113	113	0	0
2	2	93	89	0	4
2	3	32	30	0	2
2	4	7	6	0	1
2	5	4	3	0	1
3	1	8	8	0	0
3	2	8	8	0	0
3	3	2	2	0	0
3	4	1	1	0	0
3	5	1	1	0	0
Missing	1	65	64	0	1
Missing	2	19	19	0	0
Missing	3	7	7	0	0
Missing	4	7	6	1	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	117	117	0	0
0	2	40	39	1	0
0	3	24	23	1	0
0	4	14	14	0	0
0	5	4	4	0	0
0.5	1	122	121	0	1
0.5	2	40	40	0	0
0.5	3	12	12	0	0
0.5	4	6	6	0	0
0.5	5	2	1	1	0
1	1	65	65	0	0
1	2	31	31	0	0
1	3	15	15	0	0
1	4	1	1	0	0
1	5	3	3	0	0
2	1	22	22	0	0
2	2	13	13	0	0
2	3	6	6	0	0
2	4	2	2	0	0
2	5	2	2	0	0
3	1	0	0	0	0
3	2	1	1	0	0
3	3	1	1	0	0
3	4	0	0	0	0
3	5	0	0	0	0
Missing	1	15	15	0	0
Missing	2	4	4	0	0
Missing	3	0	0	0	0
Missing	4	1	1	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	122	27	95	0
0	2	40	5	35	0
0	3	25	8	17	0
0	4	15	5	10	0
0	5	4	0	4	0
0.5	1	133	49	83	1
0.5	2	45	16	29	0
0.5	3	18	7	11	0
0.5	4	6	4	2	0
0.5	5	2	1	1	0
1	1	73	40	33	0
1	2	41	24	17	0
1	3	18	14	4	0
1	4	1	0	1	0
1	5	1	0	1	0
2	1	21	16	5	0
2	2	13	9	4	0
2	3	6	3	3	0
2	4	3	2	1	0
2	5	2	2	0	0
3	1	1	1	0	0
3	2	2	2	0	0
3	3	0	0	0	0
3	4	0	0	0	0
3	5	1	1	0	0
Missing	1	17	6	11	0
Missing	2	5	0	5	0
Missing	3	0	0	0	0
Missing	4	3	3	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling	N at Floor
0	1	121	113	8	0
0	2	41	39	2	0
0	3	25	25	0	0
0	4	15	14	1	0
0	5	4	4	0	0
0.5	1	132	128	3	1
0.5	2	44	43	1	0
0.5	3	18	17	0	1
0.5	4	6	6	0	0
0.5	5	2	2	0	0
1	1	71	68	1	2
1	2	39	39	0	0
1	3	16	16	0	0
1	4	1	1	0	0
1	5	1	1	0	0
2	1	20	20	0	0
2	2	14	14	0	0
2	3	6	6	0	0
2	4	3	3	0	0
2	5	2	2	0	0
3	1	1	1	0	0
3	2	2	2	0	0
3	3	0	0	0	0
3	4	0	0	0	0
3	5	1	1	0	0
Missing	1	16	15	1	0
Missing	2	6	5	1	0
Missing	3	0	0	0	0
Missing	4	3	3	0	0

7 Floor and Ceiling (TabCAT)

7.1 Table and plots

In each plot, the y axis shows the percentage of data and the x axis shows the visit. Symbols indicate the following:

Filled circles: scores between the floor and ceiling Open squares: scores at the ceiling for that task “X”s: scores at the floor for that task

7.1.1 By Diagnosis

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	110	98	12	0
	2	52	52	0	0
	3	18	14	4	0
	4	6	5	1	0
CBD/CBS	1	32	31	1	0
	2	7	7	0	0
	3	1	1	0	0
CU or Asymptomatic	1	392	391	0	1
	2	222	218	1	3
	3	141	140	1	0
	4	54	53	1	0
	5	25	25	0	0
DLB or DLB+	1	7	7	0	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	24	23	1	0
MCI	1	297	293	4	0
	2	110	109	1	0
	3	53	52	1	0
	4	26	26	0	0
	5	14	14	0	0
Other	1	185	182	3	0
	2	73	73	0	0
	3	21	20	0	1
	4	13	13	0	0
	5	4	4	0	0
PCA	1	8	8	0	0
PCA	2	3	3	0	0
PD	1	8	8	0	0
	2	4	4	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	9	8	1	0
	2	1	1	0	0
	3	1	1	0	0
PSP	1	29	29	0	0
PSP	2	4	4	0	0
Primary Psych	1	39	39	0	0
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	43	42	1	0
	2	16	16	0	0
	3	9	9	0	0
	4	11	11	0	0
	5	1	1	0	0
bvFTD or sbvFTD	1	70	68	2	0
	2	35	34	1	0
	3	7	7	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	31	29	2	0
	2	5	4	1	0
	3	2	1	1	0
	4	0	0	0	0
nvPPA	1	32	32	0	0
	2	13	13	0	0
	3	1	1	0	0
	4	0	0	0	0
	5	0	0	0	0
svPPA	1	32	30	2	0
	2	7	7	0	0
	3	1	1	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	110	100	10
	2	52	52	0
	3	18	18	0
	4	6	6	0
CBD/CBS	1	32	31	1
	2	7	7	0
	3	1	1	0
CU or Asymptomatic	1	392	392	0
	2	222	222	0
	3	141	140	1
	4	54	53	1
	5	25	25	0
DLB or DLB+	1	7	7	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	24	23	1
MCI	1	297	296	1
	2	110	110	0
	3	53	52	1
	4	26	26	0
	5	14	13	1
Other	1	185	182	3
	2	73	73	0
	3	21	21	0
	4	13	13	0
	5	4	4	0
PCA	1	8	7	1
PCA	2	3	3	0
PD	1	8	8	0
	2	4	4	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	9	8	1
	2	1	1	0
	3	1	1	0
PSP	1	29	29	0
PSP	2	4	4	0
Primary Psych	1	39	39	0
	2	3	3	0
	4	0	0	0
Unknown	1	43	43	0
	2	16	16	0
	3	9	9	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	70	68	2
	2	35	34	1
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	31	29	2
	2	5	4	1
	3	2	1	1
	4	0	0	0
nvPPA	1	32	32	0
	2	13	13	0
	3	1	1	0
	4	0	0	0
	5	0	0	0
svPPA	1	32	29	3
	2	7	7	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	104	64	40
	2	51	29	22
	3	17	9	8
	4	6	3	3
CBD/CBS	1	31	30	1
	2	7	7	0
	3	1	1	0
CU or Asymptomatic	1	391	391	0
	2	218	218	0
	3	141	140	1
	4	54	53	1
	5	25	25	0
DLB or DLB+	1	6	6	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	24	16	8
MCI	1	296	270	26
	2	108	105	3
	3	52	50	2
	4	26	26	0
	5	14	13	1
Other	1	184	169	15
	2	73	68	5
	3	21	21	0
	4	13	13	0
	5	4	4	0
PCA	1	8	7	1
PCA	2	3	0	3
PD	1	8	8	0
	2	4	4	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	9	8	1
	2	1	1	0
	3	1	1	0
PSP	1	28	27	1
PSP	2	4	4	0
Primary Psych	1	38	38	0
	2	3	3	0
	4	0	0	0
Unknown	1	43	42	1
	2	16	16	0
	3	9	9	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	69	61	8
	2	34	29	5
	3	7	4	3
	4	2	1	1
	5	0	0	0
lvPPA	1	31	27	4
	2	5	4	1
	3	2	0	2
	4	0	0	0
nvPPA	1	32	31	1
	2	13	13	0
	3	1	1	0
	4	0	0	0
	5	0	0	0
svPPA	1	30	23	7
	2	7	5	2
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	135	94	41	0
	2	62	43	19	0
	3	19	16	3	0
	4	6	3	3	0
CBD/CBS	1	30	29	1	0
	2	6	6	0	0
	3	1	1	0	0
CU or Asymptomatic	1	421	418	0	3
	2	244	242	0	2
	3	168	166	0	2
	4	62	62	0	0
	5	27	27	0	0
DLB or DLB+	1	9	8	1	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	23	18	5	0
MCI	1	329	314	14	1
	2	129	122	4	3
	3	56	53	2	1
	4	29	28	1	0
	5	14	14	0	0
Other	1	149	144	4	1
	2	57	56	1	0
	3	27	25	1	1
	4	13	13	0	0
	5	4	4	0	0
PCA	1	12	10	2	0
PCA	2	5	2	3	0
PD	1	8	7	1	0
	2	5	5	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	11	9	2	0
	2	2	1	0	1
	3	1	1	0	0
PSP	1	31	30	1	0
PSP	2	4	4	0	0
Primary Psych	1	39	38	1	0
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	40	40	0	0
	2	16	16	0	0
	3	11	10	1	0
	4	11	11	0	0
	5	1	1	0	0
bvFTD or sbvFTD	1	79	69	10	0
	2	39	34	5	0
	3	7	5	2	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	39	35	4	0
	2	7	7	0	0
	3	2	2	0	0
	4	0	0	0	0
nvPPA	1	37	37	0	0
	2	14	14	0	0
	3	2	2	0	0
	4	0	0	0	0
	5	1	1	0	0
svPPA	1	35	30	5	0
	2	7	6	1	0
	3	1	0	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	138	128	5	5
	2	63	60	0	3
	3	20	19	0	1
	4	6	5	0	1
CBD/CBS	1	30	29	1	0
	2	6	6	0	0
	3	1	1	0	0
CU or Asymptomatic	1	438	422	0	16
	2	253	244	0	9
	3	170	165	0	5
	4	62	62	0	0
	5	27	27	0	0
DLB or DLB+	1	9	9	0	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	23	22	1	0
MCI	1	341	329	0	12
	2	133	123	0	10
	3	57	54	0	3
	4	29	28	0	1
	5	14	13	0	1
Other	1	206	191	1	14
	2	77	73	0	4
	3	27	25	0	2
	4	13	12	0	1
	5	4	3	0	1
PCA	1	13	13	0	0
PCA	2	5	5	0	0
PD	1	8	8	0	0
	2	5	5	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	11	11	0	0
	2	2	2	0	0
	3	1	1	0	0
PSP	1	31	31	0	0
PSP	2	4	4	0	0
Primary Psych	1	40	37	0	3
	2	3	1	0	2
	4	0	0	0	0
Unknown	1	43	39	0	4
	2	17	15	0	2
	3	11	11	0	0
	4	11	10	0	1
	5	1	1	0	0
bvFTD or sbvFTD	1	80	78	0	2
	2	40	40	0	0
	3	7	7	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	39	37	0	2
	2	7	7	0	0
	3	2	2	0	0
	4	0	0	0	0
nvPPA	1	38	37	0	1
	2	14	14	0	0
	3	2	2	0	0
	4	0	0	0	0
	5	1	1	0	0
svPPA	1	36	34	0	2
	2	7	7	0	0
	3	1	1	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	141	138	3
	2	63	63	0
	3	19	18	1
	4	6	6	0
CBD/CBS	1	28	28	0
	2	7	7	0
	3	1	1	0
CU or Asymptomatic	1	440	440	0
	2	254	254	0
	3	169	169	0
	4	62	62	0
	5	27	27	0
DLB or DLB+	1	9	8	1
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	24	23	1
MCI	1	342	342	0
	2	131	131	0
	3	57	57	0
	4	28	28	0
	5	14	14	0
Other	1	206	206	0
	2	78	78	0
	3	26	26	0
	4	13	13	0
	5	4	4	0
PCA	1	13	13	0
PCA	2	5	5	0
PD	1	8	8	0
	2	5	5	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	11	11	0
	2	2	2	0
	3	1	1	0
PSP	1	30	30	0
PSP	2	4	4	0
Primary Psych	1	40	40	0
	2	3	3	0
	4	0	0	0
Unknown	1	43	43	0
	2	17	17	0
	3	11	11	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	79	78	1
	2	37	35	2
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	39	38	1
	2	7	6	1
	3	2	1	1
	4	0	0	0
nvPPA	1	34	34	0
	2	12	12	0
	3	4	4	0
	4	0	0	0
	5	0	0	0
svPPA	1	34	34	0
	2	7	7	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	139	127	12	0
	2	61	59	2	0
	3	19	19	0	0
	4	6	6	0	0
CBD/CBS	1	34	33	1	0
	2	7	7	0	0
	3	1	1	0	0
CU or Asymptomatic	1	440	439	1	0
	2	254	254	0	0
	3	168	168	0	0
	4	62	61	1	0
	5	27	27	0	0
DLB or DLB+	1	9	8	1	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	23	23	0	0
MCI	1	340	338	2	0
	2	133	130	3	0
	3	58	58	0	0
	4	28	28	0	0
	5	14	14	0	0
Other	1	204	203	1	0
	2	79	79	0	0
	3	26	26	0	0
	4	13	13	0	0
	5	4	4	0	0
PCA	1	13	11	2	0
PCA	2	5	5	0	0
PD	1	8	8	0	0
	2	5	5	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	11	10	1	0
	2	1	1	0	0
	3	1	1	0	0
PSP	1	31	31	0	0
PSP	2	4	4	0	0
Primary Psych	1	40	40	0	0
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	44	44	0	0
	2	17	17	0	0
	3	11	11	0	0
	4	11	11	0	0
	5	1	1	0	0
bvFTD or sbvFTD	1	75	71	4	0
	2	37	35	2	0
	3	6	6	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	34	30	4	0
	2	5	3	2	0
	3	2	1	1	0
	4	0	0	0	0
nvPPA	1	33	33	0	0
	2	13	12	0	1
	3	1	1	0	0
	4	0	0	0	0
	5	0	0	0	0
svPPA	1	31	25	6	0
	2	6	5	1	0
	3	0	0	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	134	132	2
	2	59	59	0
	3	19	19	0
	4	6	6	0
CBD/CBS	1	34	34	0
	2	7	7	0
	3	1	1	0
CU or Asymptomatic	1	378	378	0
	2	221	221	0
	3	150	150	0
	4	58	58	0
	5	26	26	0
DLB or DLB+	1	8	8	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	24	24	0
MCI	1	305	304	1
	2	117	117	0
	3	53	53	0
	4	26	26	0
	5	14	14	0
Other	1	133	133	0
	2	55	55	0
	3	22	22	0
	4	13	13	0
	5	4	4	0
PCA	1	11	10	1
PCA	2	5	5	0
PD	1	8	8	0
	2	5	5	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	9	8	1
	2	1	1	0
	3	1	1	0
PSP	1	32	31	1
PSP	2	4	4	0
Primary Psych	1	39	39	0
	2	3	3	0
	4	0	0	0
Unknown	1	39	39	0
	2	15	15	0
	3	10	10	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	76	73	3
	2	35	34	1
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	38	35	3
	2	5	5	0
	3	1	1	0
	4	0	0	0
nvPPA	1	34	33	1
	2	14	13	1
	3	1	1	0
	4	0	0	0
	5	1	0	1
svPPA	1	32	31	1
	2	6	6	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	129	126	3
	2	60	59	1
	3	19	18	1
	4	6	6	0
CBD/CBS	1	31	31	0
	2	6	6	0
	3	1	1	0
CU or Asymptomatic	1	379	379	0
	2	222	222	0
	3	150	150	0
	4	58	58	0
	5	26	26	0
DLB or DLB+	1	7	7	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	23	23	0
MCI	1	304	303	1
	2	116	116	0
	3	52	52	0
	4	26	26	0
	5	14	14	0
Other	1	133	133	0
	2	54	54	0
	3	22	22	0
	4	13	13	0
	5	4	4	0
PCA	1	10	10	0
PCA	2	5	5	0
PD	1	8	8	0
	2	5	5	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	9	7	2
	2	1	1	0
	3	1	1	0
PSP	1	29	28	1
PSP	2	4	4	0
Primary Psych	1	39	39	0
	2	3	3	0
	4	0	0	0
Unknown	1	38	38	0
	2	15	15	0
	3	10	10	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	75	73	2
	2	35	34	1
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	38	37	1
	2	5	5	0
	3	1	1	0
	4	0	0	0
nvPPA	1	33	30	3
	2	14	13	1
	3	1	1	0
	4	0	0	0
	5	0	0	0
svPPA	1	31	31	0
	2	6	6	0
	3	0	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	134	127	7	0
	2	62	61	1	0
	3	18	17	1	0
	4	6	6	0	0
CBD/CBS	1	26	26	0	0
	2	4	4	0	0
	3	1	1	0	0
CU or Asymptomatic	1	436	432	0	4
	2	254	254	0	0
	3	169	164	0	5
	4	62	60	0	2
	5	27	27	0	0
DLB or DLB+	1	8	8	0	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	20	18	2	0
MCI	1	328	326	2	0
	2	130	128	0	2
	3	56	56	0	0
	4	28	28	0	0
	5	14	14	0	0
Other	1	202	200	1	1
	2	77	77	0	0
	3	26	26	0	0
	4	13	13	0	0
	5	4	4	0	0
PCA	1	13	13	0	0
PCA	2	5	5	0	0
PD	1	8	8	0	0
	2	5	5	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	10	10	0	0
	2	2	2	0	0
	3	1	1	0	0
PSP	1	24	24	0	0
PSP	2	3	3	0	0
Primary Psych	1	35	35	0	0
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	41	40	0	1
	2	16	16	0	0
	3	11	11	0	0
	4	11	11	0	0
	5	1	1	0	0
bvFTD or sbvFTD	1	69	68	1	0
	2	32	30	2	0
	3	6	6	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	36	35	1	0
	2	5	5	0	0
	3	1	1	0	0
	4	0	0	0	0
nvPPA	1	33	32	1	0
	2	9	8	1	0
	3	2	2	0	0
	4	0	0	0	0
	5	1	1	0	0
svPPA	1	29	29	0	0
	2	5	5	0	0
	3	1	1	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Ceiling
AD or AD+	1	108	91	17
	2	52	45	7
	3	18	14	4
	4	6	6	0
CBD/CBS	1	30	29	1
	2	6	6	0
	3	1	1	0
CU or Asymptomatic	1	432	432	0
	2	256	256	0
	3	171	171	0
	4	64	64	0
	5	27	27	0
DLB or DLB+	1	7	6	1
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	21	19	2
MCI	1	325	316	9
	2	128	128	0
	3	57	57	0
	4	28	28	0
	5	14	14	0
Other	1	201	198	3
	2	76	76	0
	3	27	27	0
	4	13	13	0
	5	4	4	0
PCA	1	6	3	3
PCA	2	4	1	3
PD	1	8	8	0
	2	5	4	1
	3	2	2	0
	4	1	1	0
PPA unspecified	1	11	11	0
	2	2	2	0
	3	1	1	0
PSP	1	30	27	3
PSP	2	4	3	1
Primary Psych	1	38	38	0
	2	3	3	0
	4	0	0	0
Unknown	1	44	42	2
	2	16	16	0
	3	11	11	0
	4	12	12	0
	5	1	1	0
bvFTD or sbvFTD	1	72	71	1
	2	37	34	3
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	34	33	1
	2	4	4	0
	3	1	1	0
	4	0	0	0
nvPPA	1	36	35	1
	2	14	14	0
	3	2	0	2
	4	0	0	0
	5	1	1	0
svPPA	1	34	34	0
	2	7	7	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Ceiling
AD or AD+	1	108	11	97
	2	52	6	46
	3	18	4	14
	4	6	0	6
CBD/CBS	1	30	1	29
	2	6	0	6
	3	1	0	1
CU or Asymptomatic	1	432	0	432
	2	256	0	256
	3	171	0	171
	4	64	0	64
	5	27	0	27
DLB or DLB+	1	7	1	6
	2	1	0	1
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	21	1	20
MCI	1	325	4	321
	2	128	0	128
	3	57	0	57
	4	28	0	28
	5	14	0	14
Other	1	201	2	199
	2	76	0	76
	3	27	0	27
	4	13	0	13
	5	4	0	4
PCA	1	6	3	3
PCA	2	4	3	1
PD	1	8	0	8
	2	5	1	4
	3	2	0	2
	4	1	0	1
PPA unspecified	1	11	0	11
	2	2	0	2
	3	1	0	1
PSP	1	30	2	28
PSP	2	4	1	3
Primary Psych	1	38	0	38
	2	3	0	3
	4	0	0	0
Unknown	1	44	0	44
	2	16	0	16
	3	11	0	11
	4	12	0	12
	5	1	0	1
bvFTD or sbvFTD	1	72	1	71
	2	37	2	35
	3	7	0	7
	4	2	0	2
	5	0	0	0
lvPPA	1	34	1	33
	2	4	0	4
	3	1	0	1
	4	0	0	0
nvPPA	1	36	1	35
	2	14	0	14
	3	2	1	1
	4	0	0	0
	5	1	0	1
svPPA	1	34	0	34
	2	7	0	7
	3	1	0	1

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor
AD or AD+	1	74	74	0
	2	34	34	0
	3	14	14	0
	4	4	4	0
CBD/CBS	1	24	24	0
	2	5	5	0
	3	1	1	0
CU or Asymptomatic	1	422	422	0
	2	246	246	0
	3	163	163	0
	4	64	64	0
	5	26	26	0
DLB or DLB+	1	6	6	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	15	15	0
MCI	1	300	299	1
	2	120	120	0
	3	52	52	0
	4	26	26	0
	5	13	13	0
Other	1	188	188	0
	2	74	74	0
	3	24	24	0
	4	13	13	0
	5	4	4	0
PCA	1	4	4	0
PCA	2	1	1	0
PD	1	8	8	0
	2	4	4	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	7	7	0
	2	2	2	0
	3	1	1	0
PSP	1	25	25	0
PSP	2	4	4	0
Primary Psych	1	37	37	0
	2	3	3	0
	4	0	0	0
Unknown	1	41	41	0
	2	17	17	0
	3	10	10	0
	4	11	11	0
	5	1	1	0
bvFTD or sbvFTD	1	63	63	0
	2	30	30	0
	3	6	6	0
	4	2	2	0
	5	0	0	0
lvPPA	1	25	24	1
	2	4	4	0
	3	1	1	0
	4	0	0	0
nvPPA	1	33	33	0
	2	13	12	1
	3	1	1	0
	4	0	0	0
	5	1	1	0
svPPA	1	32	32	0
	2	6	6	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	74	23	0	51
	2	34	10	0	24
	3	14	7	0	7
	4	4	1	0	3
CBD/CBS	1	24	5	0	19
	2	5	0	0	5
	3	1	0	0	1
CU or Asymptomatic	1	422	3	0	419
	2	246	1	0	245
	3	163	1	0	162
	4	64	0	0	64
	5	26	0	0	26
DLB or DLB+	1	6	0	0	6
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	15	2	0	13
MCI	1	300	15	1	284
	2	120	8	0	112
	3	52	3	0	49
	4	26	1	0	25
	5	13	1	0	12
Other	1	188	13	0	175
	2	74	6	0	68
	3	24	0	0	24
	4	13	0	0	13
	5	4	0	0	4
PCA	1	4	3	0	1
PCA	2	1	0	0	1
PD	1	8	0	0	8
	2	4	0	0	4
	3	2	0	0	2
	4	1	0	0	1
PPA unspecified	1	7	2	0	5
	2	2	0	0	2
	3	1	0	0	1
PSP	1	25	6	0	19
PSP	2	4	2	0	2
Primary Psych	1	37	1	0	36
	2	3	0	0	3
	4	0	0	0	0
Unknown	1	41	2	0	39
	2	17	2	0	15
	3	10	0	0	10
	4	11	0	0	11
	5	1	1	0	0
bvFTD or sbvFTD	1	63	9	0	54
	2	30	6	0	24
	3	6	1	0	5
	4	2	0	0	2
	5	0	0	0	0
lvPPA	1	25	9	1	15
	2	4	1	0	3
	3	1	1	0	0
	4	0	0	0	0
nvPPA	1	33	3	0	30
	2	13	3	1	9
	3	1	1	0	0
	4	0	0	0	0
	5	1	0	0	1
svPPA	1	32	2	0	30
	2	6	1	0	5
	3	1	0	0	1

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	135	129	5	1
	2	63	63	0	0
	3	18	18	0	0
	4	6	6	0	0
CBD/CBS	1	26	26	0	0
	2	4	4	0	0
	3	1	1	0	0
CU or Asymptomatic	1	436	414	0	22
	2	254	244	0	10
	3	169	166	0	3
	4	62	61	0	1
	5	27	27	0	0
DLB or DLB+	1	8	8	0	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	20	19	0	1
MCI	1	328	323	2	3
	2	130	128	0	2
	3	56	56	0	0
	4	28	26	0	2
	5	14	13	0	1
Other	1	202	196	0	6
	2	77	76	0	1
	3	26	26	0	0
	4	13	13	0	0
	5	4	4	0	0
PCA	1	13	13	0	0
PCA	2	5	5	0	0
PD	1	8	8	0	0
	2	5	5	0	0
	3	2	2	0	0
	4	1	1	0	0
PPA unspecified	1	10	10	0	0
	2	2	2	0	0
	3	1	1	0	0
PSP	1	24	24	0	0
PSP	2	3	3	0	0
Primary Psych	1	35	35	0	0
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	41	39	0	2
	2	16	15	0	1
	3	11	11	0	0
	4	11	11	0	0
	5	1	1	0	0
bvFTD or sbvFTD	1	69	69	0	0
	2	33	32	0	1
	3	6	6	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	36	35	1	0
	2	5	5	0	0
	3	1	1	0	0
	4	0	0	0	0
nvPPA	1	32	31	1	0
	2	9	9	0	0
	3	2	2	0	0
	4	0	0	0	0
	5	1	1	0	0
svPPA	1	29	29	0	0
	2	5	5	0	0
	3	1	1	0	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Ceiling
AD or AD+	1	130	130	0
	2	57	57	0
	3	19	19	0
	4	6	6	0
CBD/CBS	1	30	30	0
	2	6	6	0
	3	1	1	0
CU or Asymptomatic	1	439	394	45
	2	254	229	25
	3	168	146	22
	4	62	53	9
	5	27	25	2
DLB or DLB+	1	10	10	0
	2	1	1	0
	3	0	0	0
	4	0	0	0
FTD or FTLD	1	23	23	0
MCI	1	335	328	7
	2	130	124	6
	3	58	58	0
	4	28	27	1
	5	14	13	1
Other	1	204	196	8
	2	79	76	3
	3	26	23	3
	4	13	10	3
	5	4	3	1
PCA	1	9	9	0
PCA	2	5	5	0
PD	1	8	8	0
	2	4	4	0
	3	2	2	0
	4	1	1	0
PPA unspecified	1	11	11	0
	2	1	1	0
	3	1	1	0
PSP	1	31	31	0
PSP	2	4	4	0
Primary Psych	1	40	38	2
	2	3	3	0
	4	0	0	0
Unknown	1	42	38	4
	2	17	16	1
	3	11	9	2
	4	11	10	1
	5	1	1	0
bvFTD or sbvFTD	1	76	76	0
	2	36	36	0
	3	7	7	0
	4	2	2	0
	5	0	0	0
lvPPA	1	39	39	0
	2	5	5	0
	3	1	1	0
	4	0	0	0
nvPPA	1	35	34	1
	2	14	14	0
	3	3	3	0
	4	0	0	0
	5	1	1	0
svPPA	1	35	35	0
	2	7	7	0
	3	1	1	0

Diagnosis	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
AD or AD+	1	120	107	1	12
	2	55	44	1	10
	3	19	18	0	1
	4	6	5	0	1
CBD/CBS	1	33	27	0	6
	2	7	6	0	1
	3	1	1	0	0
CU or Asymptomatic	1	379	216	0	163
	2	222	127	0	95
	3	149	72	0	77
	4	58	25	0	33
	5	26	12	0	14
DLB or DLB+	1	7	7	0	0
	2	1	1	0	0
	3	0	0	0	0
	4	0	0	0	0
FTD or FTLD	1	24	20	0	4
MCI	1	299	242	1	56
	2	113	85	0	28
	3	53	39	0	14
	4	26	15	0	11
	5	14	9	0	5
Other	1	129	90	0	39
	2	54	33	0	21
	3	20	13	0	7
	4	12	7	0	5
	5	4	2	0	2
PCA	1	5	5	0	0
PCA	2	3	3	0	0
PD	1	8	7	0	1
	2	4	1	0	3
	3	2	2	0	0
	4	1	0	0	1
PPA unspecified	1	9	8	0	1
	2	1	1	0	0
	3	1	1	0	0
PSP	1	28	20	0	8
PSP	2	4	4	0	0
Primary Psych	1	39	29	0	10
	2	3	3	0	0
	4	0	0	0	0
Unknown	1	39	30	0	9
	2	15	10	0	5
	3	10	6	0	4
	4	11	8	0	3
	5	1	0	0	1
bvFTD or sbvFTD	1	76	73	1	2
	2	38	35	0	3
	3	6	6	0	0
	4	2	2	0	0
	5	0	0	0	0
lvPPA	1	37	34	3	0
	2	4	4	0	0
	3	1	1	0	0
	4	0	0	0	0
nvPPA	1	36	28	0	8
	2	14	12	0	2
	3	3	3	0	0
	4	0	0	0	0
	5	1	1	0	0
svPPA	1	30	26	4	0
	2	7	6	1	0
	3	1	0	1	0

7.1.2 By CDR

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	566	564	1	1
	2	290	286	1	3
	3	161	160	1	0
	4	68	67	1	0
	5	28	28	0	0
0.5	1	477	469	8	0
	2	156	155	1	0
	3	65	63	1	1
	4	29	29	0	0
	5	12	12	0	0
1	1	208	195	13	0
	2	62	61	1	0
	3	15	10	5	0
	4	4	3	1	0
	5	2	2	0	0
2+	1	41	36	5	0
	2	19	18	1	0
	3	5	5	0	0
	4	1	1	0	0
Missing	1	56	54	2	0
	2	29	29	0	0
	3	11	11	0	0
	4	11	11	0	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	566	565	1
	2	290	290	0
	3	161	160	1
	4	68	67	1
	5	28	28	0
0.5	1	477	472	5
	2	156	156	0
	3	65	64	1
	4	29	29	0
	5	12	11	1
1	1	208	195	13
	2	62	61	1
	3	15	14	1
	4	4	4	0
	5	2	2	0
2+	1	41	36	5
	2	19	18	1
	3	5	5	0
	4	1	1	0
Missing	1	56	55	1
	2	29	29	0
	3	11	11	0
	4	11	11	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	564	554	10
	2	286	283	3
	3	161	160	1
	4	68	67	1
	5	28	28	0
0.5	1	475	438	37
	2	154	149	5
	3	64	58	6
	4	29	28	1
	5	12	11	1
1	1	197	148	49
	2	61	35	26
	3	14	6	8
	4	4	2	2
	5	2	2	0
2+	1	40	25	15
	2	19	13	6
	3	5	4	1
	4	1	0	1
Missing	1	56	53	3
	2	28	27	1
	3	11	11	0
	4	11	11	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	584	580	1	3
	2	311	309	0	2
	3	194	192	0	2
	4	77	77	0	0
	5	31	31	0	0
0.5	1	513	483	28	2
	2	174	165	6	3
	3	71	68	1	2
	4	30	29	1	0
	5	12	12	0	0
1	1	233	186	47	0
	2	70	48	21	1
	3	16	10	6	0
	4	4	2	2	0
	5	2	2	0	0
2+	1	47	31	16	0
	2	21	16	5	0
	3	5	4	1	0
	4	1	1	0	0
Missing	1	50	50	0	0
	2	25	24	1	0
	3	11	9	2	0
	4	12	11	1	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	631	603	1	27
	2	329	315	0	14
	3	196	190	0	6
	4	77	75	0	2
	5	31	31	0	0
0.5	1	543	520	2	21
	2	182	172	0	10
	3	72	67	0	5
	4	30	28	0	2
	5	12	10	0	2
1	1	244	234	2	8
	2	73	70	0	3
	3	17	17	0	0
	4	4	4	0	0
	5	2	2	0	0
2+	1	50	46	3	1
	2	23	23	0	0
	3	5	5	0	0
	4	1	1	0	0
Missing	1	56	52	0	4
	2	30	27	0	3
	3	11	11	0	0
	4	12	12	0	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	628	628	0
	2	331	331	0
	3	195	195	0
	4	77	77	0
	5	30	30	0
0.5	1	542	541	1
	2	179	179	0
	3	72	72	0
	4	29	29	0
	5	12	12	0
1	1	244	238	6
	2	70	69	1
	3	17	15	2
	4	4	4	0
	5	2	2	0
2+	1	51	51	0
	2	23	21	2
	3	5	5	0
	4	1	1	0
Missing	1	56	56	0
	2	30	30	0
	3	11	11	0
	4	12	12	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	627	625	2	0
	2	331	331	0	0
	3	193	193	0	0
	4	77	76	1	0
	5	30	30	0	0
0.5	1	543	535	8	0
	2	179	174	4	1
	3	72	72	0	0
	4	29	29	0	0
	5	12	12	0	0
1	1	235	216	19	0
	2	68	65	3	0
	3	14	13	1	0
	4	4	4	0	0
	5	2	2	0	0
2+	1	46	41	5	0
	2	23	20	3	0
	3	5	5	0	0
	4	1	1	0	0
Missing	1	58	57	1	0
	2	30	30	0	0
	3	11	11	0	0
	4	12	12	0	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	525	524	1
	2	283	283	0
	3	171	171	0
	4	72	72	0
	5	30	29	1
0.5	1	483	479	4
	2	162	162	0
	3	66	66	0
	4	29	29	0
	5	12	12	0
1	1	230	224	6
	2	64	63	1
	3	15	15	0
	4	4	4	0
	5	2	2	0
2+	1	44	41	3
	2	19	18	1
	3	5	5	0
	4	1	1	0
Missing	1	52	52	0
	2	25	25	0
	3	11	11	0
	4	11	11	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	522	522	0
	2	283	283	0
	3	171	171	0
	4	72	72	0
	5	29	29	0
0.5	1	480	475	5
	2	160	159	1
	3	65	65	0
	4	29	29	0
	5	12	12	0
1	1	222	216	6
	2	65	64	1
	3	14	13	1
	4	4	4	0
	5	2	2	0
2+	1	43	41	2
	2	20	19	1
	3	5	5	0
	4	1	1	0
Missing	1	49	49	0
	2	24	24	0
	3	11	11	0
	4	11	11	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	621	615	1	5
	2	327	326	0	1
	3	195	190	0	5
	4	77	75	0	2
	5	31	31	0	0
0.5	1	502	500	2	0
	2	172	171	1	0
	3	69	69	0	0
	4	30	30	0	0
	5	12	12	0	0
1	1	228	218	10	0
	2	65	62	2	1
	3	15	14	1	0
	4	4	4	0	0
	5	2	2	0	0
2+	1	47	45	2	0
	2	22	21	1	0
	3	4	4	0	0
	4	1	1	0	0
Missing	1	54	53	0	1
	2	27	27	0	0
	3	11	11	0	0
	4	11	11	0	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	620	618	2
	2	330	330	0
	3	197	197	0
	4	79	79	0
	5	31	31	0
0.5	1	515	497	18
	2	176	172	4
	3	72	70	2
	4	29	29	0
	5	12	12	0
1	1	215	195	20
	2	63	56	7
	3	15	11	4
	4	4	4	0
	5	2	2	0
2+	1	32	31	1
	2	18	14	4
	3	4	4	0
	4	1	1	0
Missing	1	55	52	3
	2	28	28	0
	3	11	11	0
	4	13	13	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	620	0	620
	2	330	0	330
	3	197	0	197
	4	79	0	79
	5	31	0	31
0.5	1	515	10	505
	2	176	4	172
	3	72	2	70
	4	29	0	29
	5	12	0	12
1	1	215	15	200
	2	63	5	58
	3	15	3	12
	4	4	0	4
	5	2	0	2
2+	1	32	0	32
	2	18	4	14
	3	4	0	4
	4	1	0	1
Missing	1	55	3	52
	2	28	0	28
	3	11	0	11
	4	13	0	13
	5	2	0	2

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor
0	1	600	599	1
	2	316	316	0
	3	188	188	0
	4	78	78	0
	5	30	30	0
0.5	1	471	470	1
	2	165	165	0
	3	64	64	0
	4	27	27	0
	5	11	11	0
1	1	162	162	0
	2	43	42	1
	3	11	11	0
	4	4	4	0
	5	2	2	0
2+	1	20	20	0
	2	12	12	0
	3	3	3	0
	4	1	1	0
Missing	1	51	51	0
	2	28	28	0
	3	10	10	0
	4	11	11	0
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	600	10	1	589
	2	316	7	0	309
	3	188	1	0	187
	4	78	0	0	78
	5	30	0	0	30
0.5	1	471	47	1	423
	2	165	15	0	150
	3	64	6	0	58
	4	27	1	0	26
	5	11	1	0	10
1	1	162	31	0	131
	2	43	13	1	29
	3	11	7	0	4
	4	4	1	0	3
	5	2	0	0	2
2+	1	20	4	0	16
	2	12	3	0	9
	3	3	0	0	3
	4	1	0	0	1
Missing	1	51	6	0	45
	2	28	3	0	25
	3	10	0	0	10
	4	11	0	0	11
	5	2	1	0	1

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	621	598	0	23
	2	327	314	0	13
	3	195	192	0	3
	4	77	75	0	2
	5	31	31	0	0
0.5	1	502	495	2	5
	2	172	170	0	2
	3	69	69	0	0
	4	30	29	0	1
	5	12	11	0	1
1	1	228	217	7	4
	2	66	66	0	0
	3	15	15	0	0
	4	4	4	0	0
	5	2	2	0	0
2+	1	47	47	0	0
	2	23	23	0	0
	3	4	4	0	0
	4	1	1	0	0
Missing	1	54	51	0	3
	2	27	27	0	0
	3	11	11	0	0
	4	11	11	0	0
	5	2	2	0	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Ceiling
0	1	628	573	55
	2	331	305	26
	3	194	171	23
	4	77	68	9
	5	31	29	2
0.5	1	530	518	12
	2	175	167	8
	3	73	70	3
	4	29	25	4
	5	12	10	2
1	1	232	232	0
	2	68	68	0
	3	15	15	0
	4	4	4	0
	5	2	2	0
2+	1	48	48	0
	2	19	19	0
	3	5	5	0
	4	1	1	0
Missing	1	59	59	0
	2	30	29	1
	3	11	10	1
	4	12	11	1
	5	2	2	0

CDR Global	Visit	Total N	N not at floor/ceiling	N at Floor	N at Ceiling
0	1	525	320	1	204
	2	281	167	0	114
	3	168	87	0	81
	4	72	35	0	37
	5	30	14	0	16
0.5	1	471	374	3	94
	2	156	115	0	41
	3	67	46	0	21
	4	28	15	0	13
	5	12	8	0	4
1	1	207	190	5	12
	2	63	53	2	8
	3	15	14	1	0
	4	4	3	0	1
	5	2	1	0	1
2+	1	44	41	1	2
	2	20	19	0	1
	3	5	5	0	0
	4	1	1	0	0
Missing	1	51	44	0	7
	2	25	21	0	4
	3	11	10	0	1
	4	11	8	0	3
	5	2	1	0	1

8 AUC (PPG)

This section presents an AUC analysis comparing a single diagnostic group (e.g., svPPA) with all other diagnostic groups. CU/asymptomatic participants were excluded. First, each task was entered in its own model, and the task from the model with the highest AUC was retained. Each remaining task was then added to that model, one at a time, and the two-task model with the highest AUC was retained. This process was repeated until each model contained five tasks.

A summary table is presented first. In the table, “cases” are participants in the single diagnostic group and “controls” are all other participants. Each row adds one task to the model above it, so the AUC shows how discrimination changes as more tasks are included. The CI columns give the 95% confidence interval for the AUC. The Youden column gives the optimal cutoff value for that model.

8.1 AUCs by Diagnosis

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
AD or AD+ vs other	185	989	0.803	0.770	0.835	0.156	0.731	0.768
AD or AD+ vs other	33	266	0.866	0.797	0.934	0.143	0.816	0.818
AD or AD+ vs other	9	148	0.892	0.810	0.974	0.047	0.777	0.889
AD or AD+ vs other	9	145	0.901	0.819	0.984	0.027	0.690	1.000
AD or AD+ vs other	8	133	0.911	0.832	0.989	0.028	0.737	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
bvFTD or sbvFTD vs other	8	423	0.763	0.631	0.895	0.016	0.634	0.875
bvFTD or sbvFTD vs other	8	409	0.792	0.619	0.964	0.025	0.768	0.875
bvFTD or sbvFTD vs other	7	390	0.816	0.668	0.963	0.027	0.795	0.857
bvFTD or sbvFTD vs other	7	387	0.836	0.672	0.999	0.029	0.819	0.857
bvFTD or sbvFTD vs other	7	373	0.851	0.709	0.993	0.029	0.839	0.857

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
CBD/CBS vs other	15	289	0.807	0.714	0.899	0.074	0.799	0.733
CBD/CBS vs other	5	160	0.920	0.869	0.971	0.046	0.875	1.000
CBD/CBS vs other	5	160	0.939	0.893	0.984	0.054	0.881	1.000
CBD/CBS vs other	5	159	0.947	0.902	0.992	0.040	0.881	1.000
CBD/CBS vs other	5	145	0.952	0.906	0.998	0.045	0.883	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
CU or Asymptomatic vs other	207	1000	0.958	0.946	0.970	0.287	0.905	0.961
CU or Asymptomatic vs other	21	391	0.990	0.982	0.998	0.112	0.967	1.000
CU or Asymptomatic vs other	5	57	1.000	1.000	1.000	0.500	1.000	1.000
CU or Asymptomatic vs other	5	56	1.000	1.000	1.000	0.500	1.000	1.000
CU or Asymptomatic vs other	5	56	1.000	1.000	1.000	0.500	1.000	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
FTD or FTLD vs other	158	1049	0.822	0.792	0.853	0.143	0.787	0.715
FTD or FTLD vs other	38	273	0.908	0.863	0.954	0.087	0.780	0.921
FTD or FTLD vs other	35	268	0.918	0.875	0.961	0.168	0.862	0.886
FTD or FTLD vs other	17	216	0.935	0.867	1.000	0.101	0.889	0.941
FTD or FTLD vs other	9	62	0.971	0.933	1.000	0.102	0.855	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
lvPPA vs other	28	432	0.807	0.735	0.879	0.050	0.688	0.857
lvPPA vs other	7	152	0.908	0.791	1.000	0.051	0.855	0.857
lvPPA vs other	7	145	0.953	0.895	1.000	0.128	0.952	0.857
lvPPA vs other	7	137	0.971	0.943	0.999	0.096	0.949	1.000
lvPPA vs other	7	136	0.979	0.957	1.000	0.099	0.963	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
MCI vs other	120	1081	0.697	0.657	0.736	0.094	0.622	0.733
MCI vs other	29	384	0.772	0.699	0.846	0.074	0.737	0.724
MCI vs other	7	87	0.846	0.723	0.968	0.074	0.770	0.857
MCI vs other	6	65	0.887	0.787	0.987	0.167	0.862	0.833
MCI vs other	6	64	0.906	0.806	1.000	0.208	0.922	0.833

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
nvPPA vs other	17	248	0.827	0.750	0.904	0.058	0.698	0.941
nvPPA vs other	13	171	0.884	0.828	0.940	0.069	0.784	1.000
nvPPA vs other	13	161	0.921	0.869	0.974	0.108	0.863	0.923
nvPPA vs other	10	121	0.975	0.946	1.000	0.038	0.868	1.000
nvPPA vs other	10	117	0.996	0.988	1.000	0.200	0.983	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
svPPA vs other	97	1080	0.922	0.895	0.948	0.047	0.812	0.907
svPPA vs other	42	507	0.953	0.927	0.979	0.063	0.895	0.905
svPPA vs other	22	160	0.965	0.935	0.995	0.129	0.900	0.909
svPPA vs other	6	39	1.000	1.000	1.000	0.500	1.000	1.000
svPPA vs other	6	37	1.000	1.000	1.000	0.500	1.000	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
PSP vs other	16	288	0.765	0.683	0.848	0.042	0.604	0.938
PSP vs other	11	190	0.856	0.738	0.974	0.071	0.847	0.818
PSP vs other	5	44	0.909	0.821	0.998	0.063	0.818	1.000
PSP vs other	5	44	0.950	0.889	1.000	0.170	0.932	1.000
PSP vs other	5	40	1.000	1.000	1.000	0.500	1.000	1.000

8.2 AUCS by CDR

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
0 vs other	171	399	0.863	0.831	0.896	0.363	0.774	0.813
0 vs other	87	130	0.899	0.857	0.942	0.416	0.792	0.885
0 vs other	87	127	0.902	0.861	0.943	0.378	0.764	0.908
0 vs other	87	127	0.902	0.861	0.944	0.497	0.866	0.816
0 vs other	87	123	0.902	0.860	0.945	0.498	0.862	0.828

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
0.5 vs other	139	229	0.669	0.612	0.726	0.392	0.707	0.590
0.5 vs other	78	132	0.716	0.646	0.787	0.434	0.811	0.551
0.5 vs other	67	122	0.743	0.671	0.815	0.233	0.467	0.896
0.5 vs other	66	121	0.750	0.678	0.822	0.431	0.843	0.545
0.5 vs other	62	112	0.754	0.680	0.828	0.365	0.750	0.645

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
1 vs other	142	428	0.739	0.698	0.781	0.170	0.500	0.894
1 vs other	32	170	0.794	0.728	0.861	0.118	0.635	0.906
1 vs other	32	168	0.847	0.776	0.917	0.177	0.780	0.812
1 vs other	32	167	0.860	0.796	0.924	0.107	0.683	0.906
1 vs other	32	167	0.867	0.802	0.931	0.284	0.886	0.750

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
2+ vs other	38	532	0.857	0.803	0.911	0.090	0.827	0.711
2+ vs other	14	203	0.910	0.833	0.988	0.077	0.847	0.857
2+ vs other	12	197	0.931	0.867	0.996	0.017	0.721	1.000
2+ vs other	9	177	0.962	0.925	0.999	0.029	0.853	1.000
2+ vs other	6	171	0.971	0.935	1.000	0.033	0.895	1.000

9 AUC (TabCAT)

9.1 AUC by Diagnosis

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
MCI vs other	406	575	0.777	0.748	0.806	0.344	0.619	0.901
MCI vs other	327	437	0.878	0.853	0.902	0.282	0.675	0.948
MCI vs other	327	437	0.889	0.866	0.911	0.447	0.796	0.853
MCI vs other	313	381	0.896	0.872	0.919	0.416	0.766	0.885
MCI vs other	247	228	0.898	0.870	0.925	0.456	0.746	0.899

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
FTD or FTLD vs other	26	997	0.784	0.692	0.877	0.025	0.702	0.769
FTD or FTLD vs other	15	594	0.885	0.798	0.972	0.034	0.785	0.867
FTD or FTLD vs other	13	538	0.920	0.852	0.987	0.046	0.887	0.846
FTD or FTLD vs other	10	380	0.943	0.883	1.000	0.078	0.939	0.900
FTD or FTLD vs other	8	370	0.967	0.938	0.996	0.024	0.889	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
bvFTD or sbvFTD vs other	90	891	0.819	0.781	0.857	0.064	0.644	0.878
bvFTD or sbvFTD vs other	90	891	0.872	0.839	0.905	0.092	0.782	0.844
bvFTD or sbvFTD vs other	62	534	0.891	0.854	0.928	0.138	0.854	0.774
bvFTD or sbvFTD vs other	54	487	0.911	0.877	0.945	0.149	0.891	0.796
bvFTD or sbvFTD vs other	49	432	0.923	0.888	0.959	0.121	0.863	0.878

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
CBD/CBS vs other	30	681	0.677	0.596	0.757	0.037	0.574	0.767
CBD/CBS vs other	30	681	0.767	0.700	0.834	0.054	0.708	0.733
CBD/CBS vs other	25	565	0.782	0.708	0.856	0.046	0.549	0.920
CBD/CBS vs other	23	496	0.808	0.734	0.883	0.050	0.635	0.870
CBD/CBS vs other	23	496	0.834	0.761	0.907	0.061	0.762	0.826

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
DLB or DLB+ vs other	12	969	0.757	0.678	0.836	0.009	0.536	1.000
DLB or DLB+ vs other	6	590	0.867	0.786	0.948	0.015	0.851	0.833
DLB or DLB+ vs other	6	590	0.965	0.907	1.000	0.005	0.817	1.000
DLB or DLB+ vs other	5	531	0.997	0.992	1.000	0.075	0.991	1.000
DLB or DLB+ vs other	5	524	0.998	0.994	1.000	0.062	0.990	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
lvPPA vs other	39	722	0.807	0.747	0.867	0.044	0.706	0.769
lvPPA vs other	39	722	0.856	0.806	0.905	0.050	0.774	0.821
lvPPA vs other	21	490	0.888	0.829	0.946	0.021	0.669	0.952
lvPPA vs other	17	446	0.919	0.867	0.972	0.027	0.774	0.941
lvPPA vs other	15	436	0.945	0.909	0.980	0.025	0.810	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
nvPPA vs other	34	702	0.736	0.666	0.805	0.064	0.769	0.588
nvPPA vs other	33	675	0.871	0.827	0.915	0.060	0.818	0.818
nvPPA vs other	33	675	0.906	0.871	0.941	0.054	0.818	0.879
nvPPA vs other	33	659	0.925	0.891	0.960	0.097	0.898	0.818
nvPPA vs other	28	593	0.938	0.907	0.969	0.047	0.850	0.929

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
PD vs other	54	927	0.819	0.774	0.864	0.047	0.632	0.889
PD vs other	54	927	0.903	0.864	0.942	0.059	0.837	0.833
PD vs other	32	614	0.940	0.912	0.968	0.027	0.783	0.969
PD vs other	5	498	0.944	0.913	0.974	0.029	0.908	1.000
PD vs other	5	443	0.956	0.931	0.980	0.044	0.939	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
svPPA vs other	30	673	0.910	0.854	0.965	0.049	0.892	0.800
svPPA vs other	24	607	0.962	0.939	0.984	0.041	0.903	0.917
svPPA vs other	24	607	0.974	0.955	0.992	0.014	0.835	1.000
svPPA vs other	15	489	0.981	0.960	1.000	0.037	0.930	0.933
svPPA vs other	15	474	0.986	0.969	1.000	0.007	0.888	1.000

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
PSP vs other	44	979	0.775	0.718	0.832	0.040	0.419	0.932
PSP vs other	25	649	0.860	0.806	0.914	0.039	0.712	0.880
PSP vs other	12	482	0.919	0.860	0.978	0.016	0.693	1.000
PSP vs other	12	462	0.947	0.910	0.985	0.022	0.814	1.000
PSP vs other	12	449	0.956	0.919	0.992	0.035	0.889	0.917

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
AD or AD+ vs other	135	632	0.802	0.764	0.840	0.150	0.685	0.830
AD or AD+ vs other	135	617	0.832	0.796	0.868	0.181	0.736	0.793
AD or AD+ vs other	135	617	0.853	0.820	0.885	0.189	0.760	0.822
AD or AD+ vs other	134	603	0.869	0.839	0.899	0.215	0.814	0.799
AD or AD+ vs other	97	507	0.883	0.849	0.917	0.190	0.828	0.794

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
PCA vs other	13	773	0.963	0.947	0.980	0.014	0.895	1
PCA vs other	6	686	0.983	0.969	0.997	0.026	0.959	1
PCA vs other	5	470	0.997	0.993	1.000	0.235	0.996	1
PCA vs other	5	459	1.000	1.000	1.000	0.500	1.000	1
PCA vs other	5	446	1.000	1.000	1.000	0.500	1.000	1

9.2 AUCs by CDR

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
0 vs other	628	810	0.795	0.772	0.818	0.503	0.735	0.729
0 vs other	628	810	0.829	0.809	0.850	0.509	0.763	0.755
0 vs other	576	738	0.862	0.842	0.881	0.518	0.786	0.776
0 vs other	519	698	0.870	0.850	0.889	0.528	0.815	0.763
0 vs other	515	682	0.873	0.854	0.893	0.439	0.749	0.839

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
0.5 vs other	597	1175	0.628	0.601	0.655	0.293	0.472	0.727
0.5 vs other	597	1175	0.674	0.648	0.699	0.277	0.478	0.806
0.5 vs other	518	944	0.677	0.649	0.705	0.322	0.575	0.722
0.5 vs other	344	454	0.681	0.645	0.718	0.405	0.604	0.692
0.5 vs other	321	432	0.689	0.652	0.727	0.362	0.523	0.773

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
1 vs other	253	1734	0.798	0.768	0.827	0.105	0.715	0.771
1 vs other	253	1734	0.834	0.807	0.861	0.115	0.764	0.794
1 vs other	210	1101	0.859	0.833	0.885	0.151	0.784	0.819
1 vs other	197	1078	0.869	0.844	0.894	0.147	0.782	0.843
1 vs other	136	966	0.877	0.845	0.908	0.117	0.794	0.824

Outcome	N_Cases	N_Controls	AUC	CI_lower	CI_upper	Youden	Specificity	Sensitivity
2+ vs other	48	1390	0.862	0.815	0.910	0.018	0.672	0.875
2+ vs other	48	1390	0.895	0.852	0.939	0.021	0.739	0.917
2+ vs other	39	1275	0.915	0.882	0.948	0.011	0.678	1.000
2+ vs other	20	860	0.936	0.895	0.976	0.019	0.834	0.900
2+ vs other	19	719	0.950	0.913	0.988	0.078	0.932	0.842

10 Annualized change (PPG)

An annualized change score, (time 2 − time 1) / time in years, was calculated for each measure. Retest intervals were limited to within 1.5 years. Results are presented first in a table and then in a forest plot. The table shows annualized change in raw units and as Z scores, along with the N for each group. The forest plot displays the Z-score version of the same information for all tasks/groups.

These data were then used to estimate sample sizes for a hypothetical trial. The estimates are presented in the same way, first in a table and then in a forest plot. All results are separated by diagnosis and CDR Global.

Results are separated by diagnosis and CDR

10.1 Change by Diagnosis

Diagnosis	Mean (raw units)	SD (raw units)	Mean (Z)	SD (Z)	N	Variable
AD or AD+	2.010	2.454	0.928	0.868	65	CDR Sum of Boxes
CBD/CBS	1.534	1.865	0.845	0.800	36	CDR Sum of Boxes
DLB or DLB+	2.211	2.058	0.905	0.810	4	CDR Sum of Boxes
FTD or FTLD	2.644	2.468	1.094	0.733	47	CDR Sum of Boxes
MCI	0.077	1.146	0.061	1.292	25	CDR Sum of Boxes
PCA	1.115	1.355	0.773	0.722	12	CDR Sum of Boxes
PD	-0.750	1.061	-1.192		2	CDR Sum of Boxes
PSP	1.735	2.055	0.755	1.046	34	CDR Sum of Boxes
bvFTD or sbvFTD	1.558	2.114	0.612	1.125	27	CDR Sum of Boxes
lvPPA	0.625	0.967	0.737	1.174	10	CDR Sum of Boxes
nvPPA	1.255	2.081	0.658	1.019	28	CDR Sum of Boxes
svPPA	1.212	1.383	0.729	0.823	49	CDR Sum of Boxes
AD or AD+	-5.192	1.640	-1.429	0.140	6	CVLT-II Short Trials 1–4 Sum
CBD/CBS	-0.415	5.196	-0.147	1.837	2	CVLT-II Short Trials 1–4 Sum
FTD or FTLD	-5.172	6.236	-0.551	1.465	5	CVLT-II Short Trials 1–4 Sum
MCI	1.527	1.751	1.093	0.471	7	CVLT-II Short Trials 1–4 Sum
PSP	0.223	1.923	0.491	1.212	4	CVLT-II Short Trials 1–4 Sum
bvFTD or sbvFTD	-3.982	3.567	-1.006	0.968	7	CVLT-II Short Trials 1–4 Sum
nvPPA	-3.840	9.980	-0.025	1.861	3	CVLT-II Short Trials 1–4 Sum
svPPA	-2.882	4.075	-1.358		2	CVLT-II Short Trials 1–4 Sum
AD or AD+	-3.098	1.985	-1.340	0.143	6	CVLT-II Short Delayed Recall
CBD/CBS	-0.919	0.147	-1.299	0.208	2	CVLT-II Short Delayed Recall
FTD or FTLD	-1.674	3.124	-0.485	1.203	5	CVLT-II Short Delayed Recall
MCI	0.464	1.362	0.535	1.355	7	CVLT-II Short Delayed Recall
PSP	0.689	0.463	0.975	0.655	4	CVLT-II Short Delayed Recall
bvFTD or sbvFTD	-1.062	2.263	-0.571	1.453	7	CVLT-II Short Delayed Recall
nvPPA	-0.973	2.809	-0.466	1.521	3	CVLT-II Short Delayed Recall
svPPA	0.000	0.000			2	CVLT-II Short Delayed Recall
AD or AD+	-1.559	2.670	-0.682	1.091	57	Benson Delayed Recall
CBD/CBS	-0.811	2.736	-0.701	1.105	25	Benson Delayed Recall
DLB or DLB+	2.101	5.010	0.230	1.625	3	Benson Delayed Recall
FTD or FTLD	-1.996	4.038	-0.496	1.165	45	Benson Delayed Recall
MCI	0.574	1.982	0.429	1.141	25	Benson Delayed Recall
PCA	-0.349	1.404	-0.250	1.212	10	Benson Delayed Recall
PD	-1.698	4.670	-0.378	2.139	2	Benson Delayed Recall
PSP	0.094	3.009	0.088	1.342	32	Benson Delayed Recall
bvFTD or sbvFTD	-1.244	3.226	-0.359	1.196	28	Benson Delayed Recall
lvPPA	0.094	2.764	-0.132	1.460	11	Benson Delayed Recall
nvPPA	-0.292	2.564	-0.043	1.341	27	Benson Delayed Recall
svPPA	-1.261	4.671	-0.259	1.299	43	Benson Delayed Recall
AD or AD+	-2.525	3.734	-0.829	0.919	57	Benson Copy
CBD/CBS	-1.643	2.560	-0.552	1.225	27	Benson Copy
DLB or DLB+	0.233	0.466	0.310	0.538	4	Benson Copy
FTD or FTLD	-0.825	2.906	-0.267	1.286	43	Benson Copy
MCI	-0.475	1.699	-0.288	1.267	25	Benson Copy
PCA	-1.672	2.468	-0.666	1.292	11	Benson Copy
PD	-0.901	0.140	-0.658	0.674	2	Benson Copy
PSP	-2.397	3.255	-0.757	1.126	32	Benson Copy
bvFTD or sbvFTD	-0.740	1.913	-0.366	1.176	28	Benson Copy
lvPPA	-1.291	2.860	-0.839	0.995	11	Benson Copy
nvPPA	-0.811	2.436	-0.243	1.170	26	Benson Copy
svPPA	0.247	1.177	0.261	1.344	45	Benson Copy
AD or AD+	-2.615	3.694	-0.869	1.177	5	MoCA Total Score
CBD/CBS	-1.886	1.458	-1.106	0.155	4	MoCA Total Score
FTD or FTLD	-5.930	4.417	-1.277	0.046	4	MoCA Total Score
MCI	-3.270	4.693	-0.839	0.863	10	MoCA Total Score
PCA	-3.614		-1.278		1	MoCA Total Score
PD	1.802	0.280	1.222	0.124	2	MoCA Total Score
PSP	-0.054	3.038	0.002	1.561	5	MoCA Total Score
bvFTD or sbvFTD	-2.351	4.078	-0.572	1.178	25	MoCA Total Score
lvPPA	-0.843	2.642	-0.479	1.129	2	MoCA Total Score
nvPPA	-2.716	3.003	-0.889	0.901	10	MoCA Total Score
svPPA	-2.965	4.588	-0.781	1.253	4	MoCA Total Score
AD or AD+	15.194	25.918	0.592	1.280	15	Trails A Seconds
CBD/CBS	3.568	15.030	0.539	1.091	15	Trails A Seconds
DLB or DLB+	-1.655		-0.236		1	Trails A Seconds
FTD or FTLD	14.606	37.355	0.481	1.126	23	Trails A Seconds
MCI	-3.524	20.229	0.010	1.322	19	Trails A Seconds
PCA	-9.433	13.341	-0.871		2	Trails A Seconds
PD	0.511	10.622	-0.140	1.802	2	Trails A Seconds
PSP	6.847	30.086	0.389	1.327	13	Trails A Seconds
bvFTD or sbvFTD	12.638	25.185	0.539	1.151	27	Trails A Seconds
lvPPA	3.986	2.172	0.969	0.656	3	Trails A Seconds
nvPPA	5.010	15.143	0.449	1.199	22	Trails A Seconds
svPPA	-1.533	31.299	0.298	1.232	22	Trails A Seconds
AD or AD+	56.282	55.514	1.091	0.671	10	Trails B Seconds
CBD/CBS	17.604	44.135	0.047	1.245	13	Trails B Seconds
FTD or FTLD	67.315	84.708	0.774	1.102	14	Trails B Seconds
MCI	1.521	43.048	-0.113	1.115	20	Trails B Seconds
PCA	9.433		1.257		1	Trails B Seconds
PD	-20.857		-1.134		1	Trails B Seconds
PSP	11.664	47.282	0.946	1.175	11	Trails B Seconds
bvFTD or sbvFTD	10.726	32.246	0.271	1.256	18	Trails B Seconds
lvPPA	-5.304	21.453	0.068	1.903	3	Trails B Seconds
nvPPA	10.385	60.878	0.467	1.142	17	Trails B Seconds
svPPA	-5.496	77.291	0.187	1.403	19	Trails B Seconds
AD or AD+	-2.467	3.277	-0.817	1.062	59	Animals
CBD/CBS	-1.431	3.137	-0.500	1.125	31	Animals
DLB or DLB+	-3.728	4.357	-0.709	0.828	4	Animals
FTD or FTLD	-3.282	3.514	-0.966	0.908	46	Animals
MCI	0.724	3.949	0.138	1.189	26	Animals
PCA	-1.891	2.996	-0.588	1.121	12	Animals
PD	1.505	3.543	0.412	1.022	2	Animals
PSP	-1.781	3.150	-0.747	1.231	34	Animals
bvFTD or sbvFTD	-1.405	4.660	-0.373	1.176	28	Animals
lvPPA	-2.419	2.455	-1.018	0.517	11	Animals
nvPPA	-1.400	2.982	-0.595	1.090	26	Animals
svPPA	-2.252	2.475	-0.825	0.835	37	Animals
AD or AD+	-2.387	4.237	-0.736	1.191	56	D Words Correct
CBD/CBS	-1.031	2.177	-0.554	1.135	33	D Words Correct
DLB or DLB+	-3.008	7.643	-0.675	1.652	4	D Words Correct
FTD or FTLD	-0.965	4.072	-0.414	1.310	46	D Words Correct
MCI	-1.533	2.818	-0.737	1.138	26	D Words Correct
PCA	-0.901	3.092	-0.563	1.154	12	D Words Correct
PD	3.104	0.148	1.549	0.587	2	D Words Correct
PSP	0.204	6.949	-0.325	1.368	32	D Words Correct
bvFTD or sbvFTD	0.083	3.587	0.067	1.216	28	D Words Correct
lvPPA	-0.335	2.634	-0.242	1.161	11	D Words Correct
nvPPA	-0.689	2.709	-0.290	1.342	26	D Words Correct
svPPA	-1.393	3.434	-0.450	1.190	38	D Words Correct
AD or AD+	-1.020	2.908	-0.511	1.217	37	Design Fluency Correct
CBD/CBS	-1.311	1.897	-0.824	0.934	19	Design Fluency Correct
DLB or DLB+	-1.069	2.698	-0.034	1.911	3	Design Fluency Correct
FTD or FTLD	-1.388	3.153	-0.504	1.098	41	Design Fluency Correct
MCI	0.129	2.225	0.068	1.228	25	Design Fluency Correct
PCA	-0.732	2.016	-0.116	1.281	7	Design Fluency Correct
PD	-2.401	2.261	-1.067	0.095	2	Design Fluency Correct
PSP	-0.802	2.456	-0.551	1.281	27	Design Fluency Correct
bvFTD or sbvFTD	0.460	3.563	0.316	1.314	28	Design Fluency Correct
lvPPA	-0.358	2.355	-0.138	1.304	10	Design Fluency Correct
nvPPA	-0.293	2.432	-0.054	1.364	26	Design Fluency Correct
svPPA	-0.938	2.893	-0.109	1.272	36	Design Fluency Correct
AD or AD+	-1.298	1.003	-1.083	0.700	17	Digit Backwards Total Correct
CBD/CBS	-0.139	1.521	-0.074	1.224	15	Digit Backwards Total Correct
DLB or DLB+	0.000		0.000		1	Digit Backwards Total Correct
FTD or FTLD	-0.829	2.106	-0.420	1.284	26	Digit Backwards Total Correct
MCI	0.652	1.285	0.513	1.148	10	Digit Backwards Total Correct
PCA	0.087	0.765	-0.151	1.285	6	Digit Backwards Total Correct
PSP	-0.633	1.532	-0.533	1.289	15	Digit Backwards Total Correct
bvFTD or sbvFTD	0.000		0.000		1	Digit Backwards Total Correct
lvPPA	-1.268	0.580	-1.337	0.059	3	Digit Backwards Total Correct
nvPPA	-1.142	1.266	-0.926	0.848	13	Digit Backwards Total Correct
svPPA	0.120	2.202	-0.313	1.233	19	Digit Backwards Total Correct
AD or AD+	-1.289	1.921	-0.642	1.162	18	Digit Forwards Total Correct
CBD/CBS	-0.382	2.015	-0.209	1.354	15	Digit Forwards Total Correct
DLB or DLB+	-1.655		-0.795		1	Digit Forwards Total Correct
FTD or FTLD	-0.338	3.116	-0.108	1.348	29	Digit Forwards Total Correct
MCI	0.479	1.288	0.198	1.283	10	Digit Forwards Total Correct
PCA	-0.357	1.260	-0.272	1.177	6	Digit Forwards Total Correct
PSP	0.122	1.331	-0.115	1.390	15	Digit Forwards Total Correct
bvFTD or sbvFTD	0.000		0.000		1	Digit Forwards Total Correct
lvPPA	-1.269	0.584	-1.337	0.059	3	Digit Forwards Total Correct
nvPPA	-0.861	1.321	-0.846	0.884	13	Digit Forwards Total Correct
svPPA	0.074	2.262	-0.094	1.370	20	Digit Forwards Total Correct
AD or AD+	-5.855	5.067	-1.517	0.065	3	Stroop Color Naming Correct
CBD/CBS	-7.860	1.898	-1.299	0.208	2	Stroop Color Naming Correct
FTD or FTLD	-18.870	22.874	-1.147	0.456	3	Stroop Color Naming Correct
MCI	-0.524	10.578	-0.617	1.589	8	Stroop Color Naming Correct
PSP	-8.013	1.490	-1.133	0.190	3	Stroop Color Naming Correct
bvFTD or sbvFTD	-4.290	10.418	-0.060	1.530	6	Stroop Color Naming Correct
nvPPA	-6.388		-1.290		1	Stroop Color Naming Correct
svPPA	-4.749	5.510	-1.282	0.108	2	Stroop Color Naming Correct
AD or AD+	-2.166	3.063	-1.532		2	Stroop Interference Naming Correct
CBD/CBS	-3.674	0.587	-1.299	0.208	2	Stroop Interference Naming Correct
FTD or FTLD	-0.665	8.986	0.176	2.254	2	Stroop Interference Naming Correct
MCI	-0.794	2.323	-0.488	1.017	8	Stroop Interference Naming Correct
PSP	-6.861	0.968	-1.138	0.182	3	Stroop Interference Naming Correct
bvFTD or sbvFTD	-3.967	10.468	-0.196	1.405	6	Stroop Interference Naming Correct
nvPPA	-1.825		-1.290		1	Stroop Interference Naming Correct
svPPA	-10.566		-1.358		1	Stroop Interference Naming Correct
AD or AD+	7.762	21.454	0.686	1.142	39	Modified Trails Time
CBD/CBS	1.547	21.073	0.126	1.166	22	Modified Trails Time
DLB or DLB+	-3.103	6.207	-0.969		4	Modified Trails Time
FTD or FTLD	10.094	37.279	0.330	1.313	41	Modified Trails Time
MCI	7.689	22.339	0.206	1.308	26	Modified Trails Time
PCA	8.113	15.712	0.913	0.966	7	Modified Trails Time
PD	28.077		1.134		1	Modified Trails Time
PSP	5.920	28.757	0.325	1.287	26	Modified Trails Time
bvFTD or sbvFTD	2.213	38.101	0.111	1.278	26	Modified Trails Time
lvPPA	-4.177	34.552	0.310	1.405	11	Modified Trails Time
nvPPA	5.365	22.978	0.288	1.179	28	Modified Trails Time
svPPA	2.635	27.262	0.147	1.207	40	Modified Trails Time
AD or AD+	-2.196	4.895	-0.606	1.210	39	Modified Trails Correct
CBD/CBS	-0.766	3.607	-0.265	1.204	22	Modified Trails Correct
DLB or DLB+	-0.696	4.154	0.376	1.713	4	Modified Trails Correct
FTD or FTLD	-2.954	4.666	-0.685	1.166	41	Modified Trails Correct
MCI	-0.708	2.474	-1.238	0.099	26	Modified Trails Correct
PCA	-3.416	2.545	-0.940	0.498	7	Modified Trails Correct
PD	0.000				1	Modified Trails Correct
PSP	-1.375	3.626	-0.609	1.037	26	Modified Trails Correct
bvFTD or sbvFTD	-0.930	4.551	-0.476	1.091	26	Modified Trails Correct
lvPPA	-0.950	5.023	-0.395	1.444	11	Modified Trails Correct
nvPPA	-0.233	2.621	-0.630	1.014	28	Modified Trails Correct
svPPA	-0.060	3.198	-0.594	1.304	40	Modified Trails Correct
AD or AD+	-0.547	0.853	-0.932	0.881	55	Calculations
CBD/CBS	-0.481	0.964	-0.655	1.011	31	Calculations
DLB or DLB+	-0.567	0.675	-1.082	1.165	4	Calculations
FTD or FTLD	-0.703	1.414	-0.655	1.262	47	Calculations
MCI	-0.413	0.822	-1.063	0.732	26	Calculations
PCA	-0.377	0.656	-0.511	0.567	10	Calculations
PD	-0.401	0.567	-0.567	0.802	2	Calculations
PSP	-0.314	1.315	-0.284	1.342	30	Calculations
bvFTD or sbvFTD	-0.296	1.144	-0.309	1.239	28	Calculations
lvPPA	-0.526	0.780	-1.041	0.934	11	Calculations
nvPPA	-0.777	1.218	-0.792	1.165	29	Calculations
svPPA	-0.343	0.688	-0.600	0.889	41	Calculations
AD or AD+	-1.248	2.873	-0.761	1.040	63	BNT Total Correct
CBD/CBS	-0.071	1.802	0.197	1.362	30	BNT Total Correct
DLB or DLB+	-0.891	1.544	-0.875		3	BNT Total Correct
FTD or FTLD	-1.140	2.200	-0.958	0.983	47	BNT Total Correct
MCI	0.052	0.945	0.249	1.497	24	BNT Total Correct
PCA	-0.398	1.636	-0.354	1.023	12	BNT Total Correct
PD	0.099	1.274	-0.327	1.142	2	BNT Total Correct
PSP	-0.287	1.361	-0.250	1.343	35	BNT Total Correct
bvFTD or sbvFTD	-0.980	2.408	-0.418	1.236	22	BNT Total Correct
lvPPA	-0.927	1.609	-0.716	1.036	11	BNT Total Correct
nvPPA	-0.704	2.819	-0.162	1.176	28	BNT Total Correct
svPPA	-1.032	1.445	-0.812	0.762	40	BNT Total Correct
AD or AD+	-3.991	0.482	-1.411	0.171	2	WRAT Total
CBD/CBS	-2.045		-1.446		1	WRAT Total
FTD or FTLD	-6.410	13.662	-0.015	1.471	4	WRAT Total
MCI	-1.442	2.884	-0.625	1.317	7	WRAT Total
PSP	0.822	2.250	0.538	1.546	3	WRAT Total
bvFTD or sbvFTD	-2.296	6.254	-0.534	1.518	7	WRAT Total
nvPPA	-12.200	8.220	-1.316	0.036	2	WRAT Total
svPPA	-7.734	1.289	-1.282	0.108	2	WRAT Total
AD or AD+	-1.935	1.684	-1.368	0.110	3	Total Score Face Matching
CBD/CBS	-0.407	0.576	-1.152		2	Total Score Face Matching
FTD or FTLD	-0.918	1.770	-0.395	1.562	4	Total Score Face Matching
MCI	0.238	1.463	-0.249	1.083	8	Total Score Face Matching
PSP	-0.905	1.237	-0.883	0.770	4	Total Score Face Matching
bvFTD or sbvFTD	-0.615	2.548	0.419	1.732	5	Total Score Face Matching
nvPPA	0.948	1.341	1.341		2	Total Score Face Matching
svPPA	0.000	0.000			2	Total Score Face Matching
AD or AD+	-2.523	3.132	-0.402	1.676	3	Total Score Affect Matching
CBD/CBS	0.615	2.022	0.147	1.837	2	Total Score Affect Matching
FTD or FTLD	-1.487	1.907	-0.675	1.182	5	Total Score Affect Matching
MCI	-0.480	0.830	-0.991	0.808	8	Total Score Affect Matching
PSP	-0.486	0.869	-0.771	1.060	4	Total Score Affect Matching
bvFTD or sbvFTD	-1.595	4.957	0.140	1.386	5	Total Score Affect Matching
nvPPA	0.456	0.645	1.290		2	Total Score Affect Matching
svPPA	-0.054	1.282	-0.076	1.813	2	Total Score Affect Matching

10.2 Change by CDR

CDR Global	Mean (raw units)	SD (raw units)	Mean (Z)	SD (Z)	N	Variable
0.0	0.428	0.903	0.649	0.878	65	CDR Sum of Boxes
0.5	1.184	1.905	0.643	1.038	200	CDR Sum of Boxes
1.0	1.977	2.473	0.790	0.964	145	CDR Sum of Boxes
2.0	0.389	1.658	0.235	1.317	25	CDR Sum of Boxes
0.0	0.920	2.479	0.267	1.256	19	CVLT-II Short Trials 1–4 Sum
0.5	-1.529	3.884	-0.212	1.304	25	CVLT-II Short Trials 1–4 Sum
1.0	-3.924	4.394	-0.739	1.181	12	CVLT-II Short Trials 1–4 Sum
2.0	-5.864	4.167	-1.301	0.116	7	CVLT-II Short Trials 1–4 Sum
0.0	0.067	1.307	0.240	1.244	19	CVLT-II Short Delayed Recall
0.5	-0.263	1.346	-0.003	1.331	25	CVLT-II Short Delayed Recall
1.0	-1.891	2.425	-1.052	0.843	12	CVLT-II Short Delayed Recall
2.0	-1.649	2.792	-0.625	1.379	7	CVLT-II Short Delayed Recall
0.0	0.104	2.614	-0.050	1.259	62	Benson Delayed Recall
0.5	-0.603	3.165	-0.215	1.234	176	Benson Delayed Recall
1.0	-1.302	3.489	-0.360	1.275	127	Benson Delayed Recall
2.0	-0.999	2.796	-0.310	1.422	21	Benson Delayed Recall
0.0	-0.348	1.510	-0.224	1.122	61	Benson Copy
0.5	-0.669	2.318	-0.334	1.236	178	Benson Copy
1.0	-1.674	3.149	-0.530	1.198	128	Benson Copy
2.0	-1.524	3.475	-0.419	1.256	21	Benson Copy
0.0	-0.101	2.550	0.152	1.283	43	MoCA Total Score
0.5	-2.109	3.921	-0.550	1.154	43	MoCA Total Score
1.0	-1.657	3.728	-0.390	1.253	22	MoCA Total Score
2.0	-3.286	3.417	-1.070	0.899	9	MoCA Total Score
0.0	-2.424	18.306	-0.124	1.256	58	Trails A Seconds
0.5	3.068	24.151	0.288	1.277	92	Trails A Seconds
1.0	11.338	30.329	0.499	1.160	57	Trails A Seconds
2.0	10.650	19.106	0.588	1.312	13	Trails A Seconds
0.0	-3.800	43.724	-0.216	1.266	57	Trails B Seconds
0.5	11.839	51.601	0.198	1.276	77	Trails B Seconds
1.0	13.581	79.699	0.239	1.333	41	Trails B Seconds
2.0	26.775	50.504	0.548	1.264	8	Trails B Seconds
0.0	-0.258	3.990	-0.047	1.249	63	Animals
0.5	-1.649	3.578	-0.567	1.136	191	Animals
1.0	-2.432	3.469	-0.713	1.091	127	Animals
2.0	-1.785	3.868	-0.793	1.019	23	Animals
0.0	-0.277	2.962	-0.099	1.171	63	D Words Correct
0.5	-0.964	3.517	-0.370	1.287	181	D Words Correct
1.0	-1.324	4.812	-0.658	1.153	126	D Words Correct
2.0	-1.698	3.817	-0.394	1.316	22	D Words Correct
0.0	0.575	2.697	0.189	1.318	64	Design Fluency Correct
0.5	-0.399	2.640	-0.188	1.229	153	Design Fluency Correct
1.0	-1.376	3.031	-0.543	1.173	99	Design Fluency Correct
2.0	-0.467	3.369	-0.083	1.471	20	Design Fluency Correct
0.0	-0.519	1.596	-0.288	1.286	10	Digit Backwards Total Correct
0.5	-0.336	1.607	-0.475	1.143	69	Digit Backwards Total Correct
1.0	-0.633	1.777	-0.467	1.178	47	Digit Backwards Total Correct
2.0	-0.346	2.672	0.084	1.599	7	Digit Backwards Total Correct
0.0	0.272	1.547	0.342	1.269	10	Digit Forwards Total Correct
0.5	-0.195	1.756	-0.268	1.269	69	Digit Forwards Total Correct
1.0	-0.680	2.576	-0.342	1.254	51	Digit Forwards Total Correct
2.0	0.145	2.526	0.007	1.284	8	Digit Forwards Total Correct
0.0	1.004	8.795	-0.159	1.441	19	Stroop Color Naming Correct
0.5	-6.757	9.562	-0.838	1.155	17	Stroop Color Naming Correct
1.0	-8.670	16.784	-1.038	1.084	7	Stroop Color Naming Correct
2.0	-7.463	9.445	-0.704	1.432	4	Stroop Color Naming Correct
0.0	5.130	19.281	0.313	1.337	19	Stroop Interference Naming Correct
0.5	-2.716	8.278	-0.445	1.250	16	Stroop Interference Naming Correct
1.0	-0.994	5.509	-0.780	1.304	5	Stroop Interference Naming Correct
2.0	-1.803	6.745	0.159	1.452	4	Stroop Interference Naming Correct
0.0	0.558	16.160	-0.292	1.143	63	Modified Trails Time
0.5	3.790	25.984	0.219	1.244	169	Modified Trails Time
1.0	8.244	29.892	0.414	1.263	101	Modified Trails Time
2.0	6.711	37.073	0.044	1.313	15	Modified Trails Time
0.0	-0.105	0.525	-1.184	0.200	63	Modified Trails Correct
0.5	-0.891	3.861	-0.463	1.201	170	Modified Trails Correct
1.0	-2.020	4.062	-0.828	0.959	100	Modified Trails Correct
2.0	-0.948	4.361	0.003	1.347	15	Modified Trails Correct
0.0	-0.150	0.685	-0.395	1.230	63	Calculations
0.5	-0.403	1.057	-0.549	1.124	184	Calculations
1.0	-0.552	1.010	-0.782	1.056	124	Calculations
2.0	-0.136	1.077	-0.064	1.277	21	Calculations
0.0	0.173	1.186	0.101	1.224	60	BNT Total Correct
0.5	-0.678	2.251	-0.395	1.218	190	BNT Total Correct
1.0	-1.032	2.054	-0.726	1.014	130	BNT Total Correct
2.0	-1.005	2.022	-0.930	1.007	22	BNT Total Correct
0.0	-0.410	2.539	-0.045	1.456	18	WRAT Total
0.5	-3.374	5.803	-0.625	1.274	19	WRAT Total
1.0	-6.072	10.450	-0.818	1.269	6	WRAT Total
2.0	-0.047	1.121	-0.148	1.684	4	WRAT Total
0.0	0.017	0.485	0.204	1.266	20	Total Score Face Matching
0.5	-0.069	1.316	-0.317	1.177	19	Total Score Face Matching
1.0	-0.674	1.664	-0.240	1.521	7	Total Score Face Matching
2.0	-2.260	2.263	-1.447	0.123	4	Total Score Face Matching
0.0	0.072	1.298	0.033	1.320	20	Total Score Affect Matching
0.5	-0.834	2.553	-0.614	1.101	19	Total Score Affect Matching
1.0	-1.092	3.061	0.002	1.519	7	Total Score Affect Matching
2.0	-0.366	1.958	0.205	1.378	5	Total Score Affect Matching

10.3 Sample size by Diagnosis

Variable	Diagnosis	N	Mean (raw units)	SD (raw units)	estimated_n	Mean (Z)	SD (Z)	estimated_n_z	Drug Effect
CDR Sum of Boxes	AD or AD+	65	2.010	2.454	205	0.928	0.868	120	30% reduction
CDR Sum of Boxes	CBD/CBS	36	1.534	1.865	203	0.845	0.800	123	30% reduction
CDR Sum of Boxes	DLB or DLB+	4	2.211	2.058	119	0.905	0.810	110	30% reduction
CDR Sum of Boxes	FTD or FTLD	47	2.644	2.468	120	1.094	0.733	62	30% reduction
CDR Sum of Boxes	MCI	25	0.077	1.146	30,051	0.061	1.292	62,084	30% reduction
CDR Sum of Boxes	PCA	12	1.115	1.355	203	0.773	0.722	120	30% reduction
CDR Sum of Boxes	PD	2	-0.750	1.061	275	-1.192			30% reduction
CDR Sum of Boxes	PSP	34	1.735	2.055	193	0.755	1.046	264	30% reduction
CDR Sum of Boxes	bvFTD or sbvFTD	27	1.558	2.114	253	0.612	1.125	465	30% reduction
CDR Sum of Boxes	lvPPA	10	0.625	0.967	329	0.737	1.174	348	30% reduction
CDR Sum of Boxes	nvPPA	28	1.255	2.081	378	0.658	1.019	329	30% reduction
CDR Sum of Boxes	svPPA	49	1.212	1.383	179	0.729	0.823	175	30% reduction
CVLT-II Short Trials 1–4 Sum	AD or AD+	6	-5.192	1.640	14	-1.429	0.140	1	30% reduction
CVLT-II Short Trials 1–4 Sum	CBD/CBS	2	-0.415	5.196	21,503	-0.147	1.837	21,503	30% reduction
CVLT-II Short Trials 1–4 Sum	FTD or FTLD	5	-5.172	6.236	200	-0.551	1.465	972	30% reduction
CVLT-II Short Trials 1–4 Sum	MCI	7	1.527	1.751	181	1.093	0.471	26	30% reduction
CVLT-II Short Trials 1–4 Sum	PSP	4	0.223	1.923	10,184	0.491	1.212	839	30% reduction
CVLT-II Short Trials 1–4 Sum	bvFTD or sbvFTD	7	-3.982	3.567	110	-1.006	0.968	127	30% reduction
CVLT-II Short Trials 1–4 Sum	nvPPA	3	-3.840	9.980	928	-0.025	1.861	752,562	30% reduction
CVLT-II Short Trials 1–4 Sum	svPPA	2	-2.882	4.075	275	-1.358			30% reduction
CVLT-II Short Delayed Recall	AD or AD+	6	-3.098	1.985	56	-1.340	0.143	2	30% reduction
CVLT-II Short Delayed Recall	CBD/CBS	2	-0.919	0.147	4	-1.299	0.208	4	30% reduction
CVLT-II Short Delayed Recall	FTD or FTLD	5	-1.674	3.124	479	-0.485	1.203	844	30% reduction
CVLT-II Short Delayed Recall	MCI	7	0.464	1.362	1,186	0.535	1.355	881	30% reduction
CVLT-II Short Delayed Recall	PSP	4	0.689	0.463	62	0.975	0.655	62	30% reduction
CVLT-II Short Delayed Recall	bvFTD or sbvFTD	7	-1.062	2.263	624	-0.571	1.453	891	30% reduction
CVLT-II Short Delayed Recall	nvPPA	3	-0.973	2.809	1,144	-0.466	1.521	1,464	30% reduction
CVLT-II Short Delayed Recall	svPPA	2	0.000	0.000					30% reduction
Benson Delayed Recall	AD or AD+	57	-1.559	2.670	403	-0.682	1.091	351	30% reduction
Benson Delayed Recall	CBD/CBS	25	-0.811	2.736	1,562	-0.701	1.105	341	30% reduction
Benson Delayed Recall	DLB or DLB+	3	2.101	5.010	781	0.230	1.625	6,883	30% reduction
Benson Delayed Recall	FTD or FTLD	45	-1.996	4.038	563	-0.496	1.165	758	30% reduction
Benson Delayed Recall	MCI	25	0.574	1.982	1,640	0.429	1.141	970	30% reduction
Benson Delayed Recall	PCA	10	-0.349	1.404	2,229	-0.250	1.212	3,235	30% reduction
Benson Delayed Recall	PD	2	-1.698	4.670	1,039	-0.378	2.139	4,405	30% reduction
Benson Delayed Recall	PSP	32	0.094	3.009	142,280	0.088	1.342	32,046	30% reduction
Benson Delayed Recall	bvFTD or sbvFTD	28	-1.244	3.226	923	-0.359	1.196	1,523	30% reduction
Benson Delayed Recall	lvPPA	11	0.094	2.764	119,219	-0.132	1.460	16,802	30% reduction
Benson Delayed Recall	nvPPA	27	-0.292	2.564	10,557	-0.043	1.341	133,213	30% reduction
Benson Delayed Recall	svPPA	43	-1.261	4.671	1,885	-0.259	1.299	3,464	30% reduction
Benson Copy	AD or AD+	57	-2.525	3.734	300	-0.829	0.919	169	30% reduction
Benson Copy	CBD/CBS	27	-1.643	2.560	334	-0.552	1.225	677	30% reduction
Benson Copy	DLB or DLB+	4	0.233	0.466	550	0.310	0.538	412	30% reduction
Benson Copy	FTD or FTLD	43	-0.825	2.906	1,704	-0.267	1.286	3,182	30% reduction
Benson Copy	MCI	25	-0.475	1.699	1,757	-0.288	1.267	2,654	30% reduction
Benson Copy	PCA	11	-1.672	2.468	299	-0.666	1.292	517	30% reduction
Benson Copy	PD	2	-0.901	0.140	3	-0.658	0.674	144	30% reduction
Benson Copy	PSP	32	-2.397	3.255	253	-0.757	1.126	304	30% reduction
Benson Copy	bvFTD or sbvFTD	28	-0.740	1.913	918	-0.366	1.176	1,419	30% reduction
Benson Copy	lvPPA	11	-1.291	2.860	674	-0.839	0.995	193	30% reduction
Benson Copy	nvPPA	26	-0.811	2.436	1,240	-0.243	1.170	3,192	30% reduction
Benson Copy	svPPA	45	0.247	1.177	3,109	0.261	1.344	3,646	30% reduction
MoCA Total Score	AD or AD+	5	-2.615	3.694	274	-0.869	1.177	252	30% reduction
MoCA Total Score	CBD/CBS	4	-1.886	1.458	82	-1.106	0.155	3	30% reduction
MoCA Total Score	FTD or FTLD	4	-5.930	4.417	76	-1.277	0.046	0	30% reduction
MoCA Total Score	MCI	10	-3.270	4.693	283	-0.839	0.863	145	30% reduction
MoCA Total Score	PCA	1	-3.614			-1.278			30% reduction
MoCA Total Score	PD	2	1.802	0.280	3	1.222	0.124	1	30% reduction
MoCA Total Score	PSP	5	-0.054	3.038	426,842	0.002	1.561	132,713,583	30% reduction
MoCA Total Score	bvFTD or sbvFTD	25	-2.351	4.078	413	-0.572	1.178	582	30% reduction
MoCA Total Score	lvPPA	2	-0.843	2.642	1,350	-0.479	1.129	762	30% reduction
MoCA Total Score	nvPPA	10	-2.716	3.003	168	-0.889	0.901	141	30% reduction
MoCA Total Score	svPPA	4	-2.965	4.588	329	-0.781	1.253	354	30% reduction
Trails A Seconds	AD or AD+	15	15.194	25.918	400	0.592	1.280	641	30% reduction
Trails A Seconds	CBD/CBS	15	3.568	15.030	2,438	0.539	1.091	563	30% reduction
Trails A Seconds	DLB or DLB+	1	-1.655			-0.236			30% reduction
Trails A Seconds	FTD or FTLD	23	14.606	37.355	899	0.481	1.126	753	30% reduction
Trails A Seconds	MCI	19	-3.524	20.229	4,526	0.010	1.322	2,368,134	30% reduction
Trails A Seconds	PCA	2	-9.433	13.341	275	-0.871			30% reduction
Trails A Seconds	PD	2	0.511	10.622	59,369	-0.140	1.802	22,810	30% reduction
Trails A Seconds	PSP	13	6.847	30.086	2,653	0.389	1.327	1,594	30% reduction
Trails A Seconds	bvFTD or sbvFTD	27	12.638	25.185	546	0.539	1.151	627	30% reduction
Trails A Seconds	lvPPA	3	3.986	2.172	41	0.969	0.656	63	30% reduction
Trails A Seconds	nvPPA	22	5.010	15.143	1,255	0.449	1.199	979	30% reduction
Trails A Seconds	svPPA	22	-1.533	31.299	57,268	0.298	1.232	2,353	30% reduction
Trails B Seconds	AD or AD+	10	56.282	55.514	134	1.091	0.671	52	30% reduction
Trails B Seconds	CBD/CBS	13	17.604	44.135	864	0.047	1.245	96,521	30% reduction
Trails B Seconds	FTD or FTLD	14	67.315	84.708	218	0.774	1.102	279	30% reduction
Trails B Seconds	MCI	20	1.521	43.048	109,991	-0.113	1.115	13,268	30% reduction
Trails B Seconds	PCA	1	9.433			1.257			30% reduction
Trails B Seconds	PD	1	-20.857			-1.134			30% reduction
Trails B Seconds	PSP	11	11.664	47.282	2,258	0.946	1.175	212	30% reduction
Trails B Seconds	bvFTD or sbvFTD	18	10.726	32.246	1,242	0.271	1.256	2,953	30% reduction
Trails B Seconds	lvPPA	3	-5.304	21.453	2,248	0.068	1.903	106,834	30% reduction
Trails B Seconds	nvPPA	17	10.385	60.878	4,721	0.467	1.142	823	30% reduction
Trails B Seconds	svPPA	19	-5.496	77.291	27,168	0.187	1.403	7,761	30% reduction
Animals	AD or AD+	59	-2.467	3.277	243	-0.817	1.062	232	30% reduction
Animals	CBD/CBS	31	-1.431	3.137	660	-0.500	1.125	695	30% reduction
Animals	DLB or DLB+	4	-3.728	4.357	188	-0.709	0.828	187	30% reduction
Animals	FTD or FTLD	46	-3.282	3.514	158	-0.966	0.908	121	30% reduction
Animals	MCI	26	0.724	3.949	4,085	0.138	1.189	10,142	30% reduction
Animals	PCA	12	-1.891	2.996	345	-0.588	1.121	500	30% reduction
Animals	PD	2	1.505	3.543	761	0.412	1.022	847	30% reduction
Animals	PSP	34	-1.781	3.150	430	-0.747	1.231	373	30% reduction
Animals	bvFTD or sbvFTD	28	-1.405	4.660	1,511	-0.373	1.176	1,363	30% reduction
Animals	lvPPA	11	-2.419	2.455	141	-1.018	0.517	35	30% reduction
Animals	nvPPA	26	-1.400	2.982	623	-0.595	1.090	461	30% reduction
Animals	svPPA	37	-2.252	2.475	166	-0.825	0.835	141	30% reduction
D Words Correct	AD or AD+	56	-2.387	4.237	433	-0.736	1.191	360	30% reduction
D Words Correct	CBD/CBS	33	-1.031	2.177	613	-0.554	1.135	576	30% reduction
D Words Correct	DLB or DLB+	4	-3.008	7.643	887	-0.675	1.652	822	30% reduction
D Words Correct	FTD or FTLD	46	-0.965	4.072	2,447	-0.414	1.310	1,375	30% reduction
D Words Correct	MCI	26	-1.533	2.818	464	-0.737	1.138	327	30% reduction
D Words Correct	PCA	12	-0.901	3.092	1,619	-0.563	1.154	577	30% reduction
D Words Correct	PD	2	3.104	0.148	0	1.549	0.587	20	30% reduction
D Words Correct	PSP	32	0.204	6.949	160,170	-0.325	1.368	2,434	30% reduction
D Words Correct	bvFTD or sbvFTD	28	0.083	3.587	259,144	0.067	1.216	45,422	30% reduction
D Words Correct	lvPPA	11	-0.335	2.634	8,512	-0.242	1.161	3,153	30% reduction
D Words Correct	nvPPA	26	-0.689	2.709	2,125	-0.290	1.342	2,943	30% reduction
D Words Correct	svPPA	38	-1.393	3.434	835	-0.450	1.190	959	30% reduction
Design Fluency Correct	AD or AD+	37	-1.020	2.908	1,115	-0.511	1.217	779	30% reduction
Design Fluency Correct	CBD/CBS	19	-1.311	1.897	288	-0.824	0.934	176	30% reduction
Design Fluency Correct	DLB or DLB+	3	-1.069	2.698	876	-0.034	1.911	424,098	30% reduction
Design Fluency Correct	FTD or FTLD	41	-1.388	3.153	709	-0.504	1.098	651	30% reduction
Design Fluency Correct	MCI	25	0.129	2.225	40,683	0.068	1.228	44,740	30% reduction
Design Fluency Correct	PCA	7	-0.732	2.016	1,043	-0.116	1.281	16,693	30% reduction
Design Fluency Correct	PD	2	-2.401	2.261	122	-1.067	0.095	1	30% reduction
Design Fluency Correct	PSP	27	-0.802	2.456	1,287	-0.551	1.281	741	30% reduction
Design Fluency Correct	bvFTD or sbvFTD	28	0.460	3.563	8,234	0.316	1.314	2,379	30% reduction
Design Fluency Correct	lvPPA	10	-0.358	2.355	5,932	-0.138	1.304	12,216	30% reduction
Design Fluency Correct	nvPPA	26	-0.293	2.432	9,434	-0.054	1.364	88,725	30% reduction
Design Fluency Correct	svPPA	36	-0.938	2.893	1,308	-0.109	1.272	18,687	30% reduction
Digit Backwards Total Correct	AD or AD+	17	-1.298	1.003	82	-1.083	0.700	57	30% reduction
Digit Backwards Total Correct	CBD/CBS	15	-0.139	1.521	16,395	-0.074	1.224	37,335	30% reduction
Digit Backwards Total Correct	DLB or DLB+	1	0.000			0.000			30% reduction
Digit Backwards Total Correct	FTD or FTLD	26	-0.829	2.106	887	-0.420	1.284	1,286	30% reduction
Digit Backwards Total Correct	MCI	10	0.652	1.285	533	0.513	1.148	689	30% reduction
Digit Backwards Total Correct	PCA	6	0.087	0.765	10,705	-0.151	1.285	9,909	30% reduction
Digit Backwards Total Correct	PSP	15	-0.633	1.532	806	-0.533	1.289	805	30% reduction
Digit Backwards Total Correct	bvFTD or sbvFTD	1	0.000			0.000			30% reduction
Digit Backwards Total Correct	lvPPA	3	-1.268	0.580	29	-1.337	0.059	0	30% reduction
Digit Backwards Total Correct	nvPPA	13	-1.142	1.266	169	-0.926	0.848	115	30% reduction
Digit Backwards Total Correct	svPPA	19	0.120	2.202	46,026	-0.313	1.233	2,128	30% reduction
Digit Forwards Total Correct	AD or AD+	18	-1.289	1.921	305	-0.642	1.162	449	30% reduction
Digit Forwards Total Correct	CBD/CBS	15	-0.382	2.015	3,823	-0.209	1.354	5,755	30% reduction
Digit Forwards Total Correct	DLB or DLB+	1	-1.655			-0.795			30% reduction
Digit Forwards Total Correct	FTD or FTLD	29	-0.338	3.116	11,666	-0.108	1.348	21,589	30% reduction
Digit Forwards Total Correct	MCI	10	0.479	1.288	993	0.198	1.283	5,773	30% reduction
Digit Forwards Total Correct	PCA	6	-0.357	1.260	1,712	-0.272	1.177	2,571	30% reduction
Digit Forwards Total Correct	PSP	15	0.122	1.331	16,455	-0.115	1.390	20,003	30% reduction
Digit Forwards Total Correct	bvFTD or sbvFTD	1	0.000			0.000			30% reduction
Digit Forwards Total Correct	lvPPA	3	-1.269	0.584	29	-1.337	0.059	0	30% reduction
Digit Forwards Total Correct	nvPPA	13	-0.861	1.321	324	-0.846	0.884	150	30% reduction
Digit Forwards Total Correct	svPPA	20	0.074	2.262	129,302	-0.094	1.370	29,419	30% reduction
Stroop Color Naming Correct	AD or AD+	3	-5.855	5.067	103	-1.517	0.065	0	30% reduction
Stroop Color Naming Correct	CBD/CBS	2	-7.860	1.898	8	-1.299	0.208	4	30% reduction
Stroop Color Naming Correct	FTD or FTLD	3	-18.870	22.874	202	-1.147	0.456	22	30% reduction
Stroop Color Naming Correct	MCI	8	-0.524	10.578	55,941	-0.617	1.589	912	30% reduction
Stroop Color Naming Correct	PSP	3	-8.013	1.490	5	-1.133	0.190	4	30% reduction
Stroop Color Naming Correct	bvFTD or sbvFTD	6	-4.290	10.418	810	-0.060	1.530	89,875	30% reduction
Stroop Color Naming Correct	nvPPA	1	-6.388			-1.290			30% reduction
Stroop Color Naming Correct	svPPA	2	-4.749	5.510	185	-1.282	0.108	1	30% reduction
Stroop Interference Naming Correct	AD or AD+	2	-2.166	3.063	275	-1.532			30% reduction
Stroop Interference Naming Correct	CBD/CBS	2	-3.674	0.587	4	-1.299	0.208	4	30% reduction
Stroop Interference Naming Correct	FTD or FTLD	2	-0.665	8.986	25,050	0.176	2.254	22,604	30% reduction
Stroop Interference Naming Correct	MCI	8	-0.794	2.323	1,176	-0.488	1.017	596	30% reduction
Stroop Interference Naming Correct	PSP	3	-6.861	0.968	3	-1.138	0.182	4	30% reduction
Stroop Interference Naming Correct	bvFTD or sbvFTD	6	-3.967	10.468	957	-0.196	1.405	7,026	30% reduction
Stroop Interference Naming Correct	nvPPA	1	-1.825			-1.290			30% reduction
Stroop Interference Naming Correct	svPPA	1	-10.566			-1.358			30% reduction
Modified Trails Time	AD or AD+	39	7.762	21.454	1,050	0.686	1.142	381	30% reduction
Modified Trails Time	CBD/CBS	22	1.547	21.073	25,492	0.126	1.166	11,735	30% reduction
Modified Trails Time	DLB or DLB+	4	-3.103	6.207	550	-0.969			30% reduction
Modified Trails Time	FTD or FTLD	41	10.094	37.279	1,874	0.330	1.313	2,172	30% reduction
Modified Trails Time	MCI	26	7.689	22.339	1,160	0.206	1.308	5,521	30% reduction
Modified Trails Time	PCA	7	8.113	15.712	515	0.913	0.966	154	30% reduction
Modified Trails Time	PD	1	28.077			1.134			30% reduction
Modified Trails Time	PSP	26	5.920	28.757	3,242	0.325	1.287	2,151	30% reduction
Modified Trails Time	bvFTD or sbvFTD	26	2.213	38.101	40,740	0.111	1.278	18,225	30% reduction
Modified Trails Time	lvPPA	11	-4.177	34.552	9,399	0.310	1.405	2,815	30% reduction
Modified Trails Time	nvPPA	28	5.365	22.978	2,521	0.288	1.179	2,299	30% reduction
Modified Trails Time	svPPA	40	2.635	27.262	14,702	0.147	1.207	9,280	30% reduction
Modified Trails Correct	AD or AD+	39	-2.196	4.895	683	-0.606	1.210	547	30% reduction
Modified Trails Correct	CBD/CBS	22	-0.766	3.607	3,045	-0.265	1.204	2,842	30% reduction
Modified Trails Correct	DLB or DLB+	4	-0.696	4.154	4,891	0.376	1.713	2,858	30% reduction
Modified Trails Correct	FTD or FTLD	41	-2.954	4.666	343	-0.685	1.166	399	30% reduction
Modified Trails Correct	MCI	26	-0.708	2.474	1,676	-1.238	0.099	1	30% reduction
Modified Trails Correct	PCA	7	-3.416	2.545	76	-0.940	0.498	39	30% reduction
Modified Trails Correct	PD	1	0.000						30% reduction
Modified Trails Correct	PSP	26	-1.375	3.626	956	-0.609	1.037	399	30% reduction
Modified Trails Correct	bvFTD or sbvFTD	26	-0.930	4.551	3,292	-0.476	1.091	722	30% reduction
Modified Trails Correct	lvPPA	11	-0.950	5.023	3,838	-0.395	1.444	1,832	30% reduction
Modified Trails Correct	nvPPA	28	-0.233	2.621	17,406	-0.630	1.014	355	30% reduction
Modified Trails Correct	svPPA	40	-0.060	3.198	385,704	-0.594	1.304	661	30% reduction
Calculations	AD or AD+	55	-0.547	0.853	334	-0.932	0.881	123	30% reduction
Calculations	CBD/CBS	31	-0.481	0.964	553	-0.655	1.011	328	30% reduction
Calculations	DLB or DLB+	4	-0.567	0.675	195	-1.082	1.165	159	30% reduction
Calculations	FTD or FTLD	47	-0.703	1.414	556	-0.655	1.262	509	30% reduction
Calculations	MCI	26	-0.413	0.822	545	-1.063	0.732	65	30% reduction
Calculations	PCA	10	-0.377	0.656	415	-0.511	0.567	169	30% reduction
Calculations	PD	2	-0.401	0.567	275	-0.567	0.802	275	30% reduction
Calculations	PSP	30	-0.314	1.315	2,403	-0.284	1.342	3,070	30% reduction
Calculations	bvFTD or sbvFTD	28	-0.296	1.144	2,055	-0.309	1.239	2,208	30% reduction
Calculations	lvPPA	11	-0.526	0.780	302	-1.041	0.934	111	30% reduction
Calculations	nvPPA	29	-0.777	1.218	338	-0.792	1.165	297	30% reduction
Calculations	svPPA	41	-0.343	0.688	551	-0.600	0.889	302	30% reduction
BNT Total Correct	AD or AD+	63	-1.248	2.873	728	-0.761	1.040	257	30% reduction
BNT Total Correct	CBD/CBS	30	-0.071	1.802	88,937	0.197	1.362	6,543	30% reduction
BNT Total Correct	DLB or DLB+	3	-0.891	1.544	412	-0.875			30% reduction
BNT Total Correct	FTD or FTLD	47	-1.140	2.200	511	-0.958	0.983	145	30% reduction
BNT Total Correct	MCI	24	0.052	0.945	45,907	0.249	1.497	4,943	30% reduction
BNT Total Correct	PCA	12	-0.398	1.636	2,320	-0.354	1.023	1,149	30% reduction
BNT Total Correct	PD	2	0.099	1.274	22,810	-0.327	1.142	1,675	30% reduction
BNT Total Correct	PSP	35	-0.287	1.361	3,087	-0.250	1.343	3,974	30% reduction
BNT Total Correct	bvFTD or sbvFTD	22	-0.980	2.408	829	-0.418	1.236	1,201	30% reduction
BNT Total Correct	lvPPA	11	-0.927	1.609	414	-0.716	1.036	287	30% reduction
BNT Total Correct	nvPPA	28	-0.704	2.819	2,200	-0.162	1.176	7,212	30% reduction
BNT Total Correct	svPPA	40	-1.032	1.445	269	-0.812	0.762	121	30% reduction
WRAT Total	AD or AD+	2	-3.991	0.482	2	-1.411	0.171	2	30% reduction
WRAT Total	CBD/CBS	1	-2.045			-1.446			30% reduction
WRAT Total	FTD or FTLD	4	-6.410	13.662	624	-0.015	1.471	1,300,513	30% reduction
WRAT Total	MCI	7	-1.442	2.884	549	-0.625	1.317	611	30% reduction
WRAT Total	PSP	3	0.822	2.250	1,030	0.538	1.546	1,132	30% reduction
WRAT Total	bvFTD or sbvFTD	7	-2.296	6.254	1,019	-0.534	1.518	1,112	30% reduction
WRAT Total	nvPPA	2	-12.200	8.220	62	-1.316	0.036	0	30% reduction
WRAT Total	svPPA	2	-7.734	1.289	4	-1.282	0.108	1	30% reduction
Total Score Face Matching	AD or AD+	3	-1.935	1.684	104	-1.368	0.110	1	30% reduction
Total Score Face Matching	CBD/CBS	2	-0.407	0.576	275	-1.152			30% reduction
Total Score Face Matching	FTD or FTLD	4	-0.918	1.770	511	-0.395	1.562	2,145	30% reduction
Total Score Face Matching	MCI	8	0.238	1.463	5,190	-0.249	1.083	2,593	30% reduction
Total Score Face Matching	PSP	4	-0.905	1.237	257	-0.883	0.770	104	30% reduction
Total Score Face Matching	bvFTD or sbvFTD	5	-0.615	2.548	2,354	0.419	1.732	2,353	30% reduction
Total Score Face Matching	nvPPA	2	0.948	1.341	275	1.341			30% reduction
Total Score Face Matching	svPPA	2	0.000	0.000					30% reduction
Total Score Affect Matching	AD or AD+	3	-2.523	3.132	212	-0.402	1.676	2,394	30% reduction
Total Score Affect Matching	CBD/CBS	2	0.615	2.022	1,485	0.147	1.837	21,503	30% reduction
Total Score Affect Matching	FTD or FTLD	5	-1.487	1.907	226	-0.675	1.182	421	30% reduction
Total Score Affect Matching	MCI	8	-0.480	0.830	411	-0.991	0.808	91	30% reduction
Total Score Affect Matching	PSP	4	-0.486	0.869	440	-0.771	1.060	260	30% reduction
Total Score Affect Matching	bvFTD or sbvFTD	5	-1.595	4.957	1,326	0.140	1.386	13,488	30% reduction
Total Score Affect Matching	nvPPA	2	0.456	0.645	275	1.290			30% reduction
Total Score Affect Matching	svPPA	2	-0.054	1.282	77,862	-0.076	1.813	77,862	30% reduction

10.4 Sample size by CDR

Variable	CDR Global	N	Mean (raw units)	SD (raw units)	estimated_n	Mean (Z)	SD (Z)	estimated_n_z	Drug Effect
CDR Sum of Boxes	0.0	65	0.428	0.903	610	0.649	0.878	252	30% reduction
CDR Sum of Boxes	0.5	200	1.184	1.905	356	0.643	1.038	358	30% reduction
CDR Sum of Boxes	1.0	145	1.977	2.473	215	0.790	0.964	204	30% reduction
CDR Sum of Boxes	2.0	25	0.389	1.658	2,495	0.235	1.317	4,315	30% reduction
CVLT-II Short Trials 1–4 Sum	0.0	19	0.920	2.479	999	0.267	1.256	3,051	30% reduction
CVLT-II Short Trials 1–4 Sum	0.5	25	-1.529	3.884	887	-0.212	1.304	5,203	30% reduction
CVLT-II Short Trials 1–4 Sum	1.0	12	-3.924	4.394	172	-0.739	1.181	351	30% reduction
CVLT-II Short Trials 1–4 Sum	2.0	7	-5.864	4.167	69	-1.301	0.116	1	30% reduction
CVLT-II Short Delayed Recall	0.0	19	0.067	1.307	53,015	0.240	1.244	3,706	30% reduction
CVLT-II Short Delayed Recall	0.5	25	-0.263	1.346	3,595	-0.003	1.331	31,837,037	30% reduction
CVLT-II Short Delayed Recall	1.0	12	-1.891	2.425	226	-1.052	0.843	88	30% reduction
CVLT-II Short Delayed Recall	2.0	7	-1.649	2.792	394	-0.625	1.379	669	30% reduction
Benson Delayed Recall	0.0	62	0.104	2.614	87,386	-0.050	1.259	87,526	30% reduction
Benson Delayed Recall	0.5	176	-0.603	3.165	3,784	-0.215	1.234	4,518	30% reduction
Benson Delayed Recall	1.0	127	-1.302	3.489	987	-0.360	1.275	1,720	30% reduction
Benson Delayed Recall	2.0	21	-0.999	2.796	1,076	-0.310	1.422	2,901	30% reduction
Benson Copy	0.0	61	-0.348	1.510	2,593	-0.224	1.122	3,464	30% reduction
Benson Copy	0.5	178	-0.669	2.318	1,649	-0.334	1.236	1,875	30% reduction
Benson Copy	1.0	128	-1.674	3.149	486	-0.530	1.198	701	30% reduction
Benson Copy	2.0	21	-1.524	3.475	714	-0.419	1.256	1,234	30% reduction
MoCA Total Score	0.0	43	-0.101	2.550	87,518	0.152	1.283	9,851	30% reduction
MoCA Total Score	0.5	43	-2.109	3.921	475	-0.550	1.154	604	30% reduction
MoCA Total Score	1.0	22	-1.657	3.728	696	-0.390	1.253	1,415	30% reduction
MoCA Total Score	2.0	9	-3.286	3.417	149	-1.070	0.899	97	30% reduction
Trails A Seconds	0.0	58	-2.424	18.306	7,838	-0.124	1.256	14,169	30% reduction
Trails A Seconds	0.5	92	3.068	24.151	8,516	0.288	1.277	2,705	30% reduction
Trails A Seconds	1.0	57	11.338	30.329	983	0.499	1.160	743	30% reduction
Trails A Seconds	2.0	13	10.650	19.106	442	0.588	1.312	684	30% reduction
Trails B Seconds	0.0	57	-3.800	43.724	18,188	-0.216	1.266	4,706	30% reduction
Trails B Seconds	0.5	77	11.839	51.601	2,610	0.198	1.276	5,717	30% reduction
Trails B Seconds	1.0	41	13.581	79.699	4,732	0.239	1.333	4,274	30% reduction
Trails B Seconds	2.0	8	26.775	50.504	489	0.548	1.264	730	30% reduction
Animals	0.0	63	-0.258	3.990	32,955	-0.047	1.249	98,709	30% reduction
Animals	0.5	191	-1.649	3.578	647	-0.567	1.136	553	30% reduction
Animals	1.0	127	-2.432	3.469	280	-0.713	1.091	322	30% reduction
Animals	2.0	23	-1.785	3.868	645	-0.793	1.019	227	30% reduction
D Words Correct	0.0	63	-0.277	2.962	15,749	-0.099	1.171	19,181	30% reduction
D Words Correct	0.5	181	-0.964	3.517	1,828	-0.370	1.287	1,664	30% reduction
D Words Correct	1.0	126	-1.324	4.812	1,814	-0.658	1.153	422	30% reduction
D Words Correct	2.0	22	-1.698	3.817	695	-0.394	1.316	1,531	30% reduction
Design Fluency Correct	0.0	64	0.575	2.697	3,021	0.189	1.318	6,679	30% reduction
Design Fluency Correct	0.5	153	-0.399	2.640	6,019	-0.188	1.229	5,865	30% reduction
Design Fluency Correct	1.0	99	-1.376	3.031	667	-0.543	1.173	641	30% reduction
Design Fluency Correct	2.0	20	-0.467	3.369	7,161	-0.083	1.471	43,038	30% reduction
Digit Backwards Total Correct	0.0	10	-0.519	1.596	1,298	-0.288	1.286	2,743	30% reduction
Digit Backwards Total Correct	0.5	69	-0.336	1.607	3,142	-0.475	1.143	794	30% reduction
Digit Backwards Total Correct	1.0	47	-0.633	1.777	1,082	-0.467	1.178	875	30% reduction
Digit Backwards Total Correct	2.0	7	-0.346	2.672	8,191	0.084	1.599	49,764	30% reduction
Digit Forwards Total Correct	0.0	10	0.272	1.547	4,437	0.342	1.269	1,896	30% reduction
Digit Forwards Total Correct	0.5	69	-0.195	1.756	11,188	-0.268	1.269	3,086	30% reduction
Digit Forwards Total Correct	1.0	51	-0.680	2.576	1,974	-0.342	1.254	1,846	30% reduction
Digit Forwards Total Correct	2.0	8	0.145	2.526	41,580	0.007	1.284	4,071,032	30% reduction
Stroop Color Naming Correct	0.0	19	1.004	8.795	10,538	-0.159	1.441	11,260	30% reduction
Stroop Color Naming Correct	0.5	17	-6.757	9.562	275	-0.838	1.155	261	30% reduction
Stroop Color Naming Correct	1.0	7	-8.670	16.784	515	-1.038	1.084	150	30% reduction
Stroop Color Naming Correct	2.0	4	-7.463	9.445	220	-0.704	1.432	569	30% reduction
Stroop Interference Naming Correct	0.0	19	5.130	19.281	1,941	0.313	1.337	2,499	30% reduction
Stroop Interference Naming Correct	0.5	16	-2.716	8.278	1,277	-0.445	1.250	1,085	30% reduction
Stroop Interference Naming Correct	1.0	5	-0.994	5.509	4,222	-0.780	1.304	384	30% reduction
Stroop Interference Naming Correct	2.0	4	-1.803	6.745	1,924	0.159	1.452	11,519	30% reduction
Modified Trails Time	0.0	63	0.558	16.160	115,342	-0.292	1.143	2,103	30% reduction
Modified Trails Time	0.5	169	3.790	25.984	6,458	0.219	1.244	4,429	30% reduction
Modified Trails Time	1.0	101	8.244	29.892	1,806	0.414	1.263	1,277	30% reduction
Modified Trails Time	2.0	15	6.711	37.073	4,193	0.044	1.313	122,159	30% reduction
Modified Trails Correct	0.0	63	-0.105	0.525	3,435	-1.184	0.200	4	30% reduction
Modified Trails Correct	0.5	170	-0.891	3.861	2,581	-0.463	1.201	924	30% reduction
Modified Trails Correct	1.0	100	-2.020	4.062	555	-0.828	0.959	184	30% reduction
Modified Trails Correct	2.0	15	-0.948	4.361	2,908	0.003	1.347	30,771,186	30% reduction
Calculations	0.0	63	-0.150	0.685	2,888	-0.395	1.230	1,329	30% reduction
Calculations	0.5	184	-0.403	1.057	947	-0.549	1.124	577	30% reduction
Calculations	1.0	124	-0.552	1.010	461	-0.782	1.056	250	30% reduction
Calculations	2.0	21	-0.136	1.077	8,677	-0.064	1.277	55,381	30% reduction
BNT Total Correct	0.0	60	0.173	1.186	6,447	0.101	1.224	20,292	30% reduction
BNT Total Correct	0.5	190	-0.678	2.251	1,514	-0.395	1.218	1,306	30% reduction
BNT Total Correct	1.0	130	-1.032	2.054	544	-0.726	1.014	268	30% reduction
BNT Total Correct	2.0	22	-1.005	2.022	557	-0.930	1.007	161	30% reduction
WRAT Total	0.0	18	-0.410	2.539	5,281	-0.045	1.456	145,099	30% reduction
WRAT Total	0.5	19	-3.374	5.803	406	-0.625	1.274	572	30% reduction
WRAT Total	1.0	6	-6.072	10.450	407	-0.818	1.269	330	30% reduction
WRAT Total	2.0	4	-0.047	1.121	77,197	-0.148	1.684	17,864	30% reduction
Total Score Face Matching	0.0	20	0.017	0.485	107,251	0.204	1.266	5,300	30% reduction
Total Score Face Matching	0.5	19	-0.069	1.316	50,440	-0.317	1.177	1,895	30% reduction
Total Score Face Matching	1.0	7	-0.674	1.664	837	-0.240	1.521	5,505	30% reduction
Total Score Face Matching	2.0	4	-2.260	2.263	138	-1.447	0.123	1	30% reduction
Total Score Affect Matching	0.0	20	0.072	1.298	44,445	0.033	1.320	221,709	30% reduction
Total Score Affect Matching	0.5	19	-0.834	2.553	1,286	-0.614	1.101	441	30% reduction
Total Score Affect Matching	1.0	7	-1.092	3.061	1,080	0.002	1.519	139,117,840	30% reduction
Total Score Affect Matching	2.0	5	-0.366	1.958	3,926	0.205	1.378	6,183	30% reduction

11 Annualized change (TabCAT)