FORCE Analysis
LCC Lab Community Team & April Vang
2026-09-16
Data Version: 09/09/2026
There are 4 patients that did not consent and removed (not included in the total).
Note: Of 3046 total survey respondents, 2103 had complete data on 12 key variables (Consent, received germline genetic testing, genetic diagnosis, age at diagnosis (germline mutation), genetic test result, sex at birth, age range, cancer diagnosis, family history of stomach cancer, any gastric lesion, race/ethnicity, anti-acid medication/proton pump inhibitors). We proceed our analysis with n=2103 patients.
Figures
Self-reported cancer diagnosis. Note patients may indicate more than
one cancer.
Self-reported race/ethnicity. Note patients may report more than one
race/ethnicity.
Self-reported genes. Note patients may report more than one gene.
Self-reported genes among Stomach cancer patients. Note patients may
report more than one gene.
Self-reported gastric lesions. Note patients may report more than one
lesion.
HR genes:
Lynch genes: MLH1, MSH2, MSH6, PMS2, EPCAM
Hereditary Diffuse Gastric Cancer (HDGC) genes: CDH1, CTNNA1
Juvenile Polyposis Syndrome genes: SMAD4, BMPR1A
Peutz-Jeghers Syndrome gene: STK11 (also known as LKB1)
Li-Fraumeni Syndrome gene: TP53
Recessive cancer predisposition syndrome genes: MUTYH, NTHL1
All other genes not included: CDKN2A, ENG, NF1, PTEN
Table 1. Baseline characteristics of the BRCA1/2 carriers
| Characteristic | N = 9301 |
|---|---|
| Age | |
| Less than 29 | 27 (2.9%) |
| 30-39 | 100 (11%) |
| 40-49 | 192 (21%) |
| 50-59 | 231 (25%) |
| 60-69 | 246 (26%) |
| 70 and over | 133 (14%) |
| Missing | 1 |
| Sex | |
| Female | 888 (95%) |
| Male | 42 (4.5%) |
| Race_Ethnicity | |
| Asian or Asian American | 16 (1.7%) |
| Black or African-American | 6 (0.6%) |
| Hispanic White | 8 (0.9%) |
| Hispanic, Latino, or Latinx | 26 (2.8%) |
| Mixed race/ethnicity | 10 (1.1%) |
| Non-Hispanic White | 861 (93%) |
| Other | 3 (0.3%) |
| Stomach_Cancer | 13 (1.4%) |
| Colorectal_Cancer | 11 (1.2%) |
| Breast_Cancer | 297 (32%) |
| Ovarian_Cancer | 45 (4.8%) |
| Fam_Hist_Breast_Cancer | |
| Don't know | 23 (2.5%) |
| No | 154 (17%) |
| Yes | 753 (81%) |
| Fam_Hist_Stomach_Cancer | |
| Don't know | 149 (16%) |
| No | 570 (61%) |
| Yes | 211 (23%) |
| Any_Gastric_Lesion | 404 (43%) |
| Anti_acid_ever | 543 (58%) |
| 1 n (%) | |
Table 2. Prevalence of H. pylori and gastric lesions among BRCA1/2 carriers
| Characteristic | Overall N = 9301 |
Both N = 81 |
BRCA1 N = 3571 |
BRCA2 N = 5651 |
p-value |
|---|---|---|---|---|---|
| H_pylori | 0.42 | ||||
| No | 868 (93%) | 7 (88%) | 331 (93%) | 530 (94%) | |
| Yes | 62 (6.7%) | 1 (13%) | 26 (7.3%) | 35 (6.2%) | |
| Gastritis | 0.82 | ||||
| No | 260 (64%) | 4 (80%) | 109 (65%) | 147 (63%) | |
| Yes | 144 (36%) | 1 (20%) | 58 (35%) | 85 (37%) | |
| Missing | 526 | 3 | 190 | 333 | |
| Gastric_Ulcer | 0.72 | ||||
| No | 389 (96%) | 5 (100%) | 162 (97%) | 222 (96%) | |
| Yes | 15 (3.7%) | 0 (0%) | 5 (3.0%) | 10 (4.3%) | |
| Missing | 526 | 3 | 190 | 333 | |
| GERD | 0.52 | ||||
| No | 100 (25%) | 1 (20%) | 37 (22%) | 62 (27%) | |
| Yes | 305 (75%) | 4 (80%) | 131 (78%) | 170 (73%) | |
| Missing | 525 | 3 | 189 | 333 | |
| Intestinal_Metaplasia | 0.102 | ||||
| No | 393 (97%) | 4 (80%) | 164 (98%) | 225 (97%) | |
| Yes | 11 (2.7%) | 1 (20%) | 3 (1.8%) | 7 (3.0%) | |
| Missing | 526 | 3 | 190 | 333 | |
| Barretts_Esophagus | >0.92 | ||||
| No | 373 (92%) | 5 (100%) | 154 (92%) | 214 (92%) | |
| Yes | 31 (7.7%) | 0 (0%) | 13 (7.8%) | 18 (7.8%) | |
| Missing | 526 | 3 | 190 | 333 | |
| Pernicious_Anemia | 0.132 | ||||
| No | 403 (43%) | 5 (63%) | 166 (46%) | 232 (41%) | |
| Yes | 527 (57%) | 3 (38%) | 191 (54%) | 333 (59%) | |
| Stomach_Cancer | >0.92 | ||||
| No | 917 (99%) | 8 (100%) | 352 (99%) | 557 (99%) | |
| Yes | 13 (1.4%) | 0 (0%) | 5 (1.4%) | 8 (1.4%) | |
| Colorectal_Cancer | 0.0082 | ||||
| No | 919 (99%) | 7 (88%) | 350 (98%) | 562 (99%) | |
| Yes | 11 (1.2%) | 1 (13%) | 7 (2.0%) | 3 (0.5%) | |
| 1 n (%) | |||||
| 2 Fisher’s exact test | |||||