全景分析表:全体表型及相关改变值的彻底探索
Characteristic 1. 减重不足 (<5%或反弹)
N = 11
1
2. 中度减重 (5%-10%)
N = 31
1
3. 极显著减重 (≥10%)
N = 37
1
p-value2
age 27 ± 7 29 ± 5 29 ± 5 0.5
Ht 164 ± 5 164 ± 6 164 ± 6 0.7
Glu0_T0 5.34 ± 0.50 5.33 ± 0.67 5.59 ± 0.52 0.12
Glu30_T0 8.25 ± 1.04 8.72 ± 1.40 8.68 ± 1.25 0.6
Glu60_T0 8.74 ± 1.47 8.86 ± 2.07 8.66 ± 1.40 >0.9
Glu120_T0 6.67 ± 1.22 7.66 ± 1.56 6.82 ± 1.19 0.039
Glu180_T0 5.04 ± 1.14 5.89 ± 1.77 5.83 ± 1.34 0.2
Ins0_T0 17 ± 7 19 ± 11 18 ± 8 >0.9
Ins30_T0 112 ± 74 113 ± 66 112 ± 64 >0.9
Ins60_T0 124 ± 68 125 ± 78 126 ± 58 0.8
Ins120_T0 111 ± 97 127 ± 93 96 ± 64 0.4
Ins180_T0 36 ± 23 80 ± 84 64 ± 70 0.5
HOMAIR_T0 4.10 ± 1.77 4.61 ± 3.23 4.48 ± 2.06 0.8
Matsuda_T0 3.37 ± 2.54 2.99 ± 1.73 2.71 ± 1.05 0.9
Stumvoll1_T0 407 ± 200 351 ± 207 350 ± 189 0.9
Stumvoll2_T0 134 ± 42 124 ± 42 123 ± 38 0.9
AUGC_T0 283 ± 183 306 ± 187 281 ± 143 >0.9
AUGI_T0 28.8 ± 3.0 30.9 ± 5.0 29.9 ± 3.4 0.4
UA_T0 347 ± 79 361 ± 73 353 ± 87 0.8
ALT_T0 34 ± 21 33 ± 27 32 ± 28 0.6
AST_T0 22 ± 8 22 ± 11 21 ± 9 0.7
GGT_T0 28 ± 13 25 ± 15 25 ± 15 0.6
TC_T0 4.50 ± 0.60 4.56 ± 0.84 4.59 ± 0.98 >0.9
TG_T0 1.76 ± 0.91 1.58 ± 0.75 1.29 ± 0.49 0.13
HDL_C_T0 1.09 ± 0.24 1.13 ± 0.25 1.23 ± 0.35 0.3
LDL_C_T0 2.79 ± 0.58 2.84 ± 0.75 3.02 ± 0.79 0.6
hsCRP_T0 2.6 ± 2.4 4.4 ± 3.8 4.8 ± 3.7 0.10
FSH_T0 4.48 ± 1.60 4.83 ± 1.47 4.97 ± 1.60 0.7
LH_T0 3.52 ± 1.58 5.64 ± 3.12 5.76 ± 3.80 0.2
LH_FSH_T0 0.86 ± 0.40 1.25 ± 0.74 1.21 ± 0.76 0.4
E2_T0 42 ± 33 39 ± 24 33 ± 21 0.4
P_T0 0.58 ± 1.14 0.69 ± 1.46 0.51 ± 1.40 0.6
T_T0 0.47 ± 0.22 0.50 ± 0.18 0.49 ± 0.17 0.7
PRL_T0 26 ± 8 21 ± 20 26 ± 24 0.011
SHBG_T0 25 ± 10 24 ± 10 26 ± 18 >0.9
DHEAS_T0 224 ± 52 222 ± 101 258 ± 120 0.4
ASD_T0 2.07 ± 0.96 2.68 ± 1.74 2.93 ± 1.51 0.3
FAI_T0 7.8 ± 4.6 8.8 ± 5.6 8.8 ± 6.4 0.9
Adiponectin_T0 6.80 ± 1.99 7.09 ± 2.61 7.98 ± 2.41 0.2
WC_T0 92 ± 8 94 ± 12 94 ± 11 >0.9
HC_T0 111 ± 9 108 ± 9 110 ± 9 0.7
Whtr_T0 0.56 ± 0.04 0.57 ± 0.07 0.57 ± 0.07 >0.9
SBP_T0 119 ± 14 116 ± 11 120 ± 15 0.4
DBP_T0 70 ± 8 72 ± 9 73 ± 10 0.4
HR_T0 84 ± 10 89 ± 12 86 ± 12 0.4
HGS_T0 27.4 ± 4.4 26.9 ± 3.7 26.7 ± 4.3 0.9
Wt_T0 84 ± 15 84 ± 14 84 ± 12 >0.9
SM_T0 26.9 ± 4.1 26.1 ± 3.8 26.0 ± 3.5 0.8
FM_T0 35 ± 9 36 ± 10 36 ± 9 >0.9
BMI_T0 31.0 ± 4.5 31.1 ± 4.2 30.9 ± 3.9 >0.9
FR_T0 41.4 ± 4.4 42.8 ± 6.0 43.1 ± 5.4 0.5
FFM_T0 48.8 ± 6.9 47.6 ± 6.4 47.3 ± 5.9 0.8
SMI_T0 7.79 ± 1.03 7.49 ± 0.70 7.52 ± 0.80 0.7
VFA_T0 165 ± 38 175 ± 47 173 ± 38 0.9
ROV_T0 11.4 ± 6.7 10.3 ± 4.1 11.4 ± 4.8 0.5
LOV_T0 9.01 ± 3.02 8.42 ± 3.42 9.12 ± 2.88 0.5
Menstrual_cycle_T0 60 ± 47 57 ± 66 50 ± 26 0.6
Menstrual_duration_T0 5.90 ± 1.60 6.05 ± 1.94 5.82 ± 2.54 0.7
Cycle_regularity_T0 34 ± 34 49 ± 73 39 ± 37 >0.9
mFG_T0 2.60 ± 2.07 1.84 ± 1.61 2.67 ± 2.40 0.4
Acne_T0


0.6
    0 6 (60%) 11 (35%) 11 (31%)
    1 3 (30%) 17 (55%) 21 (58%)
    2 1 (10%) 3 (9.7%) 3 (8.3%)
    3 0 (0%) 0 (0%) 1 (2.8%)
TFEQ_CR_T0 20.7 ± 4.3 21.8 ± 5.3 23.2 ± 4.7 0.3
TFEQ_UE_T0 12.80 ± 2.70 16.10 ± 2.60 15.56 ± 3.09 0.009
TFEQ_EE_T0 12.7 ± 3.6 15.1 ± 5.0 15.9 ± 4.3 0.11
PSQI_T0 8.3 ± 4.4 7.4 ± 3.4 8.3 ± 3.8 0.6
Anxiety_T0 44 ± 11 44 ± 13 43 ± 13 0.8
Depression_T0 48 ± 11 47 ± 13 49 ± 14 0.6
IPAQ_T0 898 ± 689 1,423 ± 1,552 971 ± 948 0.5
Delta_Glu0 0.01 ± 0.53 -0.22 ± 0.69 -0.36 ± 0.72 0.2
Delta_Glu30 -0.28 ± 1.46 -0.76 ± 1.43 -0.59 ± 1.64 0.8
Delta_Glu60 -1.10 ± 1.89 -1.32 ± 2.08 -0.38 ± 2.20 0.3
Delta_Glu120 -0.08 ± 1.80 -1.09 ± 1.64 0.25 ± 1.60 0.012
Delta_Glu180 0.79 ± 1.35 -0.74 ± 1.76 -0.29 ± 1.45 0.027
Delta_Ins0 -4 ± 5 -6 ± 11 -8 ± 7 0.040
Delta_Ins30 -15 ± 83 -23 ± 71 -43 ± 57 0.14
Delta_Ins60 -31 ± 48 -37 ± 81 -59 ± 52 0.038
Delta_Ins120 -46 ± 99 -54 ± 88 -38 ± 59 0.9
Delta_Ins180 25 ± 45 -40 ± 82 -35 ± 65 0.003
Delta_HOMAIR -0.89 ± 1.10 -1.68 ± 3.25 -2.23 ± 1.83 0.037
Delta_Matsuda 0.43 ± 2.58 1.61 ± 2.64 2.66 ± 1.79 0.003
Delta_Stumvoll1 -2 ± 141 40 ± 171 -27 ± 233 0.4
Delta_Stumvoll2 -2 ± 28 5 ± 35 -9 ± 45 0.3
Delta_AUGC -65 ± 119 -98 ± 207 -122 ± 126 0.2
Delta_AUGI -1.1 ± 3.9 -3.6 ± 5.2 -1.1 ± 5.3 0.2
Delta_UA 3 ± 69 -35 ± 42 -43 ± 89 0.075
Delta_ALT -3 ± 12 -14 ± 25 -16 ± 26 0.5
Delta_AST -1 ± 4 -6 ± 11 -4 ± 9 0.7
Delta_GGT -5 ± 8 -6 ± 10 -9 ± 16 0.3
Delta_TC 0.08 ± 0.43 -0.21 ± 0.69 -0.21 ± 0.85 0.3
Delta_TG 0.14 ± 0.71 -0.29 ± 0.69 -0.35 ± 0.45 0.10
Delta_HDL_C -0.04 ± 0.17 0.46 ± 2.31 -0.07 ± 0.35 0.2
Delta_LDL_C 0.00 ± 0.33 -0.22 ± 0.52 -0.25 ± 1.00 0.14
Delta_hsCRP -0.16 ± 2.40 -0.57 ± 3.02 -1.22 ± 3.03 0.2
Delta_FSH 0.22 ± 1.96 0.16 ± 1.77 0.06 ± 1.29 >0.9
Delta_LH 0.5 ± 2.7 -0.4 ± 3.4 1.4 ± 5.3 0.2
Delta_LH_FSH 0.15 ± 1.11 -0.11 ± 0.51 0.35 ± 1.47 0.2
Delta_E2 11 ± 62 -2 ± 46 18 ± 60 0.020
Delta_P 3.68 ± 10.24 -0.21 ± 2.14 0.08 ± 2.24 0.3
Delta_T -0.04 ± 0.18 -0.03 ± 0.15 -0.04 ± 0.12 0.8
Delta_PRL 6 ± 36 -2 ± 11 -4 ± 8 0.3
Delta_SHBG -1 ± 7 1 ± 5 7 ± 6 <0.001
Delta_DHEAS 13 ± 52 28 ± 85 15 ± 80 >0.9
Delta_ASD 0.13 ± 0.44 0.06 ± 1.10 -0.22 ± 1.37 0.6
Delta_FAI -0.4 ± 3.8 -0.5 ± 4.0 -2.8 ± 3.3 0.026
Delta_Adiponectin 0.75 ± 3.81 0.87 ± 2.17 0.70 ± 1.95 0.5
Delta_WC -4.0 ± 4.2 -7.6 ± 5.2 -11.1 ± 6.2 0.001
Delta_HC -2.3 ± 3.4 -4.4 ± 3.8 -8.9 ± 4.8 <0.001
Delta_Whtr -0.02 ± 0.02 -0.05 ± 0.03 -0.07 ± 0.04 <0.001
Delta_SBP -3 ± 9 0 ± 12 -8 ± 13 0.033
Delta_DBP -3 ± 7 0 ± 12 -4 ± 9 0.9
Delta_HR 5 ± 13 -6 ± 14 2 ± 14 0.052
Delta_HGS -0.7 ± 2.4 -1.3 ± 3.5 -0.8 ± 4.9 0.5
Delta_Wt -2.5 ± 1.5 -6.3 ± 1.6 -11.0 ± 2.6 <0.001
Delta_SM -0.60 ± 0.95 -0.95 ± 0.98 -1.63 ± 1.09 0.006
Delta_FM -1.4 ± 1.6 -4.6 ± 1.9 -8.4 ± 2.7 <0.001
Delta_BMI -0.95 ± 0.47 -2.32 ± 0.54 -4.07 ± 0.89 <0.001
Delta_FR -0.64 ± 1.78 -2.54 ± 1.98 -5.08 ± 2.44 <0.001
Delta_FFM -1.04 ± 1.52 -1.65 ± 1.73 -2.62 ± 1.83 0.026
Delta_SMI -0.18 ± 0.24 -0.29 ± 0.24 -0.48 ± 0.18 <0.001
Delta_VFA -6 ± 10 -21 ± 12 -45 ± 26 <0.001
Delta_ROV -1.3 ± 3.1 -0.2 ± 3.8 -2.0 ± 4.7 0.4
Delta_LOV -1.84 ± 2.93 1.07 ± 2.42 -0.89 ± 4.01 0.034
Delta_Menstrual_cycle -8 ± 55 -5 ± 40 -7 ± 17 0.5
Delta_Menstrual_duration 0.10 ± 1.66 0.13 ± 1.09 0.06 ± 1.48 >0.9
Delta_Cycle_regularity -5 ± 53 -17 ± 38 -18 ± 41 0.6
Delta_mFG -1.00 ± 2.05 -0.10 ± 2.29 -0.75 ± 1.25 0.2
Delta_Acne


0.4
    -2 0 (0%) 1 (3.3%) 0 (0%)
    -1 3 (30%) 4 (13%) 6 (17%)
    0 5 (50%) 21 (70%) 28 (78%)
    1 2 (20%) 4 (13%) 2 (5.6%)
Delta_TFEQ_CR -1.4 ± 4.6 -2.4 ± 4.4 -4.1 ± 4.1 0.10
Delta_TFEQ_UE 3.7 ± 3.8 1.1 ± 2.7 1.9 ± 3.4 0.2
Delta_TFEQ_EE 2.2 ± 4.9 -1.2 ± 4.5 -2.2 ± 3.7 0.031
Delta_PSQI -1.60 ± 4.33 -1.17 ± 2.15 -1.25 ± 3.02 0.6
Delta_Anxiety -2 ± 10 -2 ± 7 -4 ± 9 0.7
Delta_Depression -2 ± 10 -1 ± 8 -2 ± 8 0.8
Delta_IPAQ -127 ± 934 -76 ± 1,322 122 ± 1,435 0.5
1 Mean ± SD; n (%)
2 Kruskal-Wallis rank sum test; Fisher’s exact test