Relatório de citometria - Taurina HCPA
Comparações pareadas, entre grupos e variações pós-intervenção
Análise em R
20/06/2026
1 Objetivo e estratégia
Este relatório analisa dados de citometria de indivíduos com diabetes avaliados em dois momentos:
- T1 / baseline:
recoleta = Nao, códigos comoTAU76. - T2 / pós-intervenção:
recoleta = Sim, códigos comoTAU76R. - Grupos: coluna
grupo, com níveis151e452.
A análise é organizada em três etapas:
- Comparações pareadas entre T1 e T2 no mesmo indivíduo.
- Comparações entre os grupos 151 e 452 em cada tempo.
- Comparações da variação individual, calculada como
delta = T2 - T1, entre os grupos.
Como a amostra é pequena, as tabelas priorizam testes não
paramétricos de Wilcoxon. Os testes t também são apresentados como
referência. Os valores de p ajustados usam
Benjamini-Hochberg dentro de cada família de análise.
2 Amostra
| dataset | grupo | tempo | n_registros |
|---|---|---|---|
| T1-T4_Abril-2025_GROUP_Z | 151 | T1_baseline | 6 |
| T1-T4_Abril-2025_GROUP_Z | 151 | T2_pos | 8 |
| T1-T4_Abril-2025_GROUP_Z | 452 | T1_baseline | 7 |
| T1-T4_Abril-2025_GROUP_Z | 452 | T2_pos | 7 |
| T1-T6_10-Jun-2026_GROUP_V | 151 | T1_baseline | 7 |
| T1-T6_10-Jun-2026_GROUP_V | 151 | T2_pos | 7 |
| T1-T6_10-Jun-2026_GROUP_V | 452 | T1_baseline | 10 |
| T1-T6_10-Jun-2026_GROUP_V | 452 | T2_pos | 12 |
| dataset | grupo | n_individuos_com_algum_par |
|---|---|---|
| T1-T4_Abril-2025_GROUP_Z | 151 | 5 |
| T1-T4_Abril-2025_GROUP_Z | 452 | 7 |
| T1-T6_10-Jun-2026_GROUP_V | 151 | 7 |
| T1-T6_10-Jun-2026_GROUP_V | 452 | 10 |
3 Comparações T1 vs T2
As tabelas abaixo mostram as variáveis com menor p
pareado de Wilcoxon em cada arquivo. A coluna delta_media e
delta_mediana representa T2 - T1; valores
positivos indicam aumento após a intervenção.
3.1 T1-T6_10-Jun-2026_GROUP_V
| variable | label | n_pares | T1 | T2 | delta_mediana | delta_media | p_wilcoxon_pareado | p_wilcoxon_pareado_ajustado | p_t_pareado |
|---|---|---|---|---|---|---|---|---|---|
| v4 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 15 | n=15; mediana=46.4 [39.25; 57.55]; média=48.4; DP=12.81 | n=15; mediana=39.5 [32.75; 47.95]; média=40.01; DP=10.4 | -8.700 | -8.3867 | 0.0070 | 0.5269 | 0.0029 |
| v64 | T4_C12FDG_PBMC/Single Cells/Q6: C12FDG+ , CD3+ | Freq. of Parent | 14 | n=14; mediana=2.065 [1.685; 2.43]; média=2.025; DP=0.8171 | n=14; mediana=3.135 [2.12; 3.452]; média=3.301; DP=2.137 | 1.095 | 1.2757 | 0.0084 | 0.5269 | 0.0357 |
| v20 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 15 | n=15; mediana=14.7 [10.85; 18.25]; média=16.62; DP=8.188 | n=15; mediana=21.1 [14.3; 27.4]; média=23.34; DP=13.5 | 5.200 | 6.7207 | 0.0115 | 0.5269 | 0.0614 |
| v142 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 15 | n=15; mediana=13.9 [11.2; 19.4]; média=17.71; DP=9.682 | n=15; mediana=20.2 [17.15; 28.45]; média=25.61; DP=16.09 | 5.890 | 7.9013 | 0.0184 | 0.5269 | 0.0700 |
| v71 | T4_C12FDG_PBMC/Single Cells/Q13: C12FDG- , CD4+ | Freq. of Parent | 14 | n=14; mediana=36.8 [28.37; 41.55]; média=35.91; DP=10.24 | n=14; mediana=32.35 [21.4; 35.78]; média=29.38; DP=9.862 | -7.150 | -6.5221 | 0.0202 | 0.5269 | 0.0092 |
| v13 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset/Q3: CD4+ , CD8- | Freq. of Parent | 15 | n=15; mediana=60 [49; 64.8]; média=56.91; DP=10.22 | n=15; mediana=56.1 [45.25; 59.35]; média=51.7; DP=10.39 | -3.400 | -5.2067 | 0.0214 | 0.5269 | 0.0819 |
| v66 | T4_C12FDG_PBMC/Single Cells/Q8: C12FDG- , CD3- | Freq. of Parent | 14 | n=14; mediana=31.55 [28.35; 35.4]; média=32.04; DP=7.428 | n=14; mediana=38.1 [31.9; 42.55]; média=36.72; DP=6.695 | 5.400 | 4.6786 | 0.0238 | 0.5269 | 0.0173 |
| v126 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 15 | n=15; mediana=65 [55.7; 68.85]; média=63.51; DP=9.003 | n=15; mediana=59.1 [49.25; 63.05]; média=58.03; DP=10.08 | -6.600 | -5.4867 | 0.0248 | 0.5269 | 0.0142 |
| v41 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 15 | n=15; mediana=14.5 [9.665; 17.95]; média=14.65; DP=6.33 | n=15; mediana=17.4 [14.65; 22.6]; média=19.55; DP=9.415 | 3.740 | 4.8987 | 0.0249 | 0.5269 | 0.0200 |
| v131 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/H2Ax- | Freq. of Parent | 15 | n=15; mediana=98.6 [98.1; 98.8]; média=98.27; DP=0.9286 | n=15; mediana=97.6 [96.4; 98.3]; média=96.13; DP=3.933 | -0.900 | -2.1333 | 0.0258 | 0.5269 | 0.0620 |
| v63 | T4_C12FDG_PBMC/Single Cells/Q5: C12FDG- , CD3+ | Freq. of Parent | 14 | n=14; mediana=57.45 [50.1; 64.57]; média=55.91; DP=11.43 | n=14; mediana=51 [43.3; 57.2]; média=49.45; DP=12.63 | -10.250 | -6.4571 | 0.0280 | 0.5269 | 0.0257 |
| v135 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q3: CD4+ , CD8- | Freq. of Parent | 15 | n=15; mediana=62.4 [52.85; 69.2]; média=59.91; DP=10.74 | n=15; mediana=55.7 [48.45; 60.1]; média=52.09; DP=12.26 | -7.700 | -7.8200 | 0.0332 | 0.5269 | 0.0482 |
| v51 | T3_Monocytes_PBMC/Single Cells/Q5: CD56- , CD16+ | Freq. of Parent | 15 | n=15; mediana=16.7 [11.45; 20.2]; média=16.84; DP=5.988 | n=15; mediana=17.9 [16.45; 27]; média=20.67; DP=6.981 | 1.700 | 3.8367 | 0.0356 | 0.5269 | 0.0363 |
| v34 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q3: CD4+ , CD8- | Freq. of Parent | 15 | n=15; mediana=66.3 [56.25; 69.95]; média=63.3; DP=8.886 | n=15; mediana=59.2 [55.15; 66.3]; média=59.1; DP=8.451 | -4.600 | -4.2000 | 0.0382 | 0.5269 | 0.0242 |
| v130 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/H2Ax+ | Freq. of Parent | 15 | n=15; mediana=1.4 [1.24; 1.92]; média=1.747; DP=0.9264 | n=15; mediana=2.36 [1.66; 3.615]; média=3.853; DP=3.944 | 0.850 | 2.1067 | 0.0438 | 0.5269 | 0.0654 |
| v27 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+ | Median (uPAR) | 15 | n=15; mediana=1188 [922; 1480]; média=1252; DP=448.7 | n=15; mediana=1410 [1156; 1594]; média=1390; DP=405.5 | 146.000 | 137.8667 | 0.0438 | 0.5269 | 0.0402 |
| v98 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q14: CD4+ , LAG-3+ | Freq. of Parent | 17 | n=17; mediana=0.73 [0.68; 1.2]; média=0.8912; DP=0.4102 | n=17; mediana=1.19 [0.83; 1.68]; média=1.424; DP=1.051 | 0.470 | 0.5329 | 0.0442 | 0.5269 | 0.0499 |
| v74 | T4_C12FDG_PBMC/Single Cells/Q16: C12FDG- , CD4- | Freq. of Parent | 14 | n=14; mediana=46.4 [40.35; 51.6]; média=46.47; DP=7.892 | n=14; mediana=50.55 [46.48; 53.15]; média=50.77; DP=5.588 | 3.100 | 4.3000 | 0.0446 | 0.5269 | 0.0181 |
| v117 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q33: CD8- , PD-1+ | Freq. of Parent | 17 | n=17; mediana=2.21 [1.13; 2.36]; média=2.237; DP=1.308 | n=17; mediana=2.74 [2.11; 3.98]; média=3.708; DP=3.43 | 0.790 | 1.4712 | 0.0468 | 0.5269 | 0.0634 |
| v96 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q12: CD4- , TIM-3- | Freq. of Parent | 17 | n=17; mediana=38.9 [31.2; 47.2]; média=38.31; DP=10.41 | n=17; mediana=43.1 [35.8; 46.9]; média=43.74; DP=10.3 | 1.500 | 5.4235 | 0.0468 | 0.5269 | 0.0545 |
3.2 T1-T4_Abril-2025_GROUP_Z
| variable | label | n_pares | T1 | T2 | delta_mediana | delta_media | p_wilcoxon_pareado | p_wilcoxon_pareado_ajustado | p_t_pareado |
|---|---|---|---|---|---|---|---|---|---|
| z135 | T4_PBMC/Single Cells/Q3: CD3+ , CD4- | Freq. of Parent | 12 | n=12; mediana=26.1 [18.53; 30.5]; média=25.83; DP=8.269 | n=12; mediana=30.2 [19.9; 31.88]; média=27.28; DP=8.833 | 1.250 | 1.4417 | 0.0310 | 0.5269 | 0.0226 |
| z6 | T1_PBMC/Single Cells/Q1: CD4- , CD8+ | Freq. of Parent | 12 | n=12; mediana=16.85 [11.32; 24.1]; média=17.56; DP=9.161 | n=12; mediana=19.45 [13.47; 24.78]; média=19.28; DP=9.03 | 1.750 | 1.7233 | 0.0455 | 0.5269 | 0.0425 |
| z112 | T3_PBMC/Single Cells/CD14 subset+CD16 subset+P16 subset- | Freq. of Parent | 12 | n=12; mediana=2.38 [1.717; 3.312]; média=2.692; DP=1.771 | n=12; mediana=1.66 [1.358; 1.912]; média=1.679; DP=0.5378 | -0.840 | -1.0133 | 0.0653 | 0.5625 | 0.0536 |
| z115 | T3_PBMC/Single Cells/CD14 subset-CD16 subset+P16 subset+ | Freq. of Parent | 12 | n=12; mediana=0.925 [0.8275; 1.28]; média=1.067; DP=0.4142 | n=12; mediana=0.84 [0.73; 1.022]; média=0.9042; DP=0.2199 | -0.125 | -0.1625 | 0.0776 | 0.5625 | 0.1154 |
| z49 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q2: CD4+ , CD8+ | Freq. of Parent | 12 | n=12; mediana=0.54 [0.4275; 0.755]; média=0.6475; DP=0.3387 | n=12; mediana=0.655 [0.505; 0.79]; média=0.785; DP=0.4925 | 0.050 | 0.1375 | 0.0828 | 0.5625 | 0.0935 |
| z89 | T3_PBMC/Single Cells/Q17: CD14- , P16+ | Freq. of Parent | 12 | n=12; mediana=0.385 [0.2975; 0.545]; média=0.4425; DP=0.2056 | n=12; mediana=0.295 [0.2675; 0.3625]; média=0.3233; DP=0.1202 | -0.120 | -0.1192 | 0.0910 | 0.5625 | 0.0801 |
| z5 | T1_PBMC/Single Cells/CD127 subset | Freq. of Parent | 12 | n=12; mediana=48.15 [43.85; 54.2]; média=48.2; DP=7.769 | n=12; mediana=46.15 [39.72; 51.1]; média=45.4; DP=6.399 | -2.200 | -2.8000 | 0.0917 | 0.5625 | 0.0606 |
| z102 | T3_PBMC/Single Cells/CD3 subset+ P16 subset+ | Freq. of Parent | 12 | n=12; mediana=2.365 [2.018; 3.025]; média=2.637; DP=1.151 | n=12; mediana=2.165 [1.745; 2.315]; média=2.163; DP=0.5439 | -0.275 | -0.4733 | 0.1078 | 0.5962 | 0.1258 |
| z129 | T4_PBMC/Single Cells/CD3 subset | Freq. of Parent | 12 | n=12; mediana=73 [66.18; 79.5]; média=71.57; DP=8.841 | n=12; mediana=76.8 [68.6; 79.92]; média=74.12; DP=7.473 | 1.450 | 2.5500 | 0.1261 | 0.6213 | 0.1065 |
| z136 | T4_PBMC/Single Cells/Q4: CD3- , CD4- | Freq. of Parent | 12 | n=12; mediana=22.8 [17.98; 31.92]; média=25.86; DP=9.049 | n=12; mediana=20.25 [18.08; 29.35]; média=23.47; DP=7.428 | -2.050 | -2.3917 | 0.1261 | 0.6213 | 0.1067 |
| z142 | T4_PBMC/Single Cells/CD3 subset- | Freq. of Parent | 12 | n=12; mediana=27 [20.5; 33.83]; média=28.43; DP=8.841 | n=12; mediana=23.2 [20.08; 31.4]; média=25.88; DP=7.473 | -1.450 | -2.5500 | 0.1261 | 0.6213 | 0.1065 |
| z78 | T3_PBMC/Single Cells/Q6: CD3+ , CD14+ | Freq. of Parent | 12 | n=12; mediana=1.94 [1.385; 3.02]; média=2.285; DP=1.256 | n=12; mediana=1.615 [1.06; 1.98]; média=1.634; DP=0.7361 | -0.535 | -0.6508 | 0.1261 | 0.6213 | 0.1267 |
| z86 | T3_PBMC/Single Cells/Q14: CD3+ , P16+ | Freq. of Parent | 12 | n=12; mediana=1.855 [1.488; 2.377]; média=2.062; DP=1.034 | n=12; mediana=1.56 [1.355; 1.835]; média=1.667; DP=0.4979 | -0.190 | -0.3950 | 0.1466 | 0.6503 | 0.1641 |
| z65 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q18: CD8+ , uPAR+ | Freq. of Parent | 12 | n=12; mediana=1.4 [1.218; 2.315]; média=1.812; DP=0.8014 | n=12; mediana=2.145 [1.575; 3.042]; média=2.285; DP=1.041 | 0.595 | 0.4725 | 0.1698 | 0.7080 | 0.1588 |
| z84 | T3_PBMC/Single Cells/Q12: CD3- , CD56- | Freq. of Parent | 12 | n=12; mediana=20.65 [16.38; 24.58]; média=22.42; DP=9.28 | n=12; mediana=28.15 [23.85; 33.92]; média=28.5; DP=8.542 | 5.350 | 6.0767 | 0.1698 | 0.7080 | 0.1182 |
| z7 | T1_PBMC/Single Cells/Q2: CD4+ , CD8+ | Freq. of Parent | 12 | n=12; mediana=0.35 [0.31; 0.54]; média=0.5817; DP=0.5411 | n=12; mediana=0.505 [0.3775; 0.615]; média=0.6542; DP=0.5418 | 0.090 | 0.0725 | 0.1820 | 0.7362 | 0.1470 |
| z131 | T4_PBMC/Single Cells/CD14 subset | Freq. of Parent | 12 | n=12; mediana=22.5 [18.92; 25.4]; média=23.31; DP=8.491 | n=12; mediana=22.3 [20.17; 26.88]; média=24.18; DP=7.333 | 2.550 | 0.8750 | 0.1954 | 0.7362 | 0.7673 |
| z144 | T4_PBMC/Single Cells/CD14 subset- | Freq. of Parent | 12 | n=12; mediana=77.5 [74.6; 81.08]; média=76.69; DP=8.491 | n=12; mediana=77.7 [73.12; 79.82]; média=75.82; DP=7.333 | -2.550 | -0.8750 | 0.1954 | 0.7362 | 0.7673 |
| z105 | T3_PBMC/Single Cells/CD3 subset+CD56 subset-P16 subset+ | Freq. of Parent | 12 | n=12; mediana=1.515 [1.145; 2.07]; média=1.613; DP=0.7453 | n=12; mediana=1.29 [1.225; 1.45]; média=1.307; DP=0.3213 | -0.200 | -0.3067 | 0.2240 | 0.7362 | 0.1814 |
| z4 | T1_PBMC/Single Cells/CD25 subset | Freq. of Parent | 12 | n=12; mediana=27.05 [25.05; 30.08]; média=28.42; DP=5.086 | n=12; mediana=26 [22.68; 29.12]; média=26.92; DP=7.266 | -2.200 | -1.5000 | 0.2240 | 0.7362 | 0.5626 |
4 Comparações entre grupos
Nesta seção, os grupos 151 e 452 são comparados separadamente em T1 e
T2. A coluna diferenca_mediana_452_menos_151 é a mediana do
grupo 452 menos a mediana do grupo 151.
4.1 T1-T4_Abril-2025_GROUP_Z - T1_baseline
| variable | label | n_151 | n_452 | grupo_151 | grupo_452 | diferenca_mediana_452_menos_151 | p_wilcoxon | p_wilcoxon_ajustado | p_t |
|---|---|---|---|---|---|---|---|---|---|
| z134 | T4_PBMC/Single Cells/Q2: CD3+ , CD4+ | Freq. of Parent | 6 | 7 | n=6; mediana=45.7 [43; 46.68]; média=46.53; DP=6.551 | n=7; mediana=36.4 [33.55; 40.35]; média=37.34; DP=4.735 | -9.3000 | 0.0124 | 0.3908 | 0.0189 |
| z108 | T3_PBMC/Single Cells/CD3 subset-CD56 subset+P16 subset- | Freq. of Parent | 6 | 7 | n=6; mediana=1.42 [1.052; 1.848]; média=1.497; DP=0.6226 | n=7; mediana=2.74 [2.42; 3.965]; média=4.264; DP=4.083 | 1.3200 | 0.0268 | 0.3908 | 0.1247 |
| z126 | T4_PBMC/Single Cells | Median (CD4) | 6 | 7 | n=6; mediana=1335 [1080; 1528]; média=1515; DP=711.2 | n=7; mediana=757 [667.5; 1108]; média=885.3; DP=283.7 | -578.0000 | 0.0538 | 0.3908 | 0.0854 |
| z130 | T4_PBMC/Single Cells/CD4 subset | Freq. of Parent | 6 | 7 | n=6; mediana=50.9 [46.9; 53.03]; média=51.58; DP=6.114 | n=7; mediana=41.5 [38.2; 47.95]; média=43.03; DP=5.566 | -9.4000 | 0.0538 | 0.3908 | 0.0250 |
| z143 | T4_PBMC/Single Cells/CD4 subset- | Freq. of Parent | 6 | 7 | n=6; mediana=49.1 [46.97; 53.1]; média=48.42; DP=6.114 | n=7; mediana=58.5 [52.05; 61.8]; média=56.97; DP=5.566 | 9.4000 | 0.0538 | 0.3908 | 0.0250 |
| z10 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset+Q1: CD4- , CD8+-Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z11 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset+Q1: CD4- , CD8+-Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z13 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset+Q1: CD4- , CD8+Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z14 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset-Q1: CD4- , CD8+-Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z149 | T4_PBMC/Single Cells/C12+-CD14 subset-CD16 subset+ | Freq. of Parent | 6 | 7 | n=6; mediana=21 [18.92; 22.78]; média=20.88; DP=3.719 | n=7; mediana=25.1 [23.6; 30.4]; média=26.41; DP=5.743 | 4.1000 | 0.1004 | 0.3908 | 0.0624 |
| z15 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset-Q1: CD4- , CD8+-Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z16 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset-Q1: CD4- , CD8+Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z17 | T1_PBMC/Single Cells/CD3 subset+CD25 subset+CD127 subset-Q1: CD4- , CD8+Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z18 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset+Q1: CD4- , CD8+-Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z19 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset+Q1: CD4- , CD8+-Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z20 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset+Q1: CD4- , CD8+Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z21 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset+Q1: CD4- , CD8+Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z22 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset-Q1: CD4- , CD8+-Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z23 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset-Q1: CD4- , CD8+-Q3: CD4+ , CD8– | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
| z24 | T1_PBMC/Single Cells/CD3 subset+CD25 subset-CD127 subset-Q1: CD4- , CD8+Q3: CD4+ , CD8-+ | Freq. of Parent | 6 | 7 | n=6; mediana=-0.004325 [-0.0048; -0.004]; média=-0.004455; DP=0.0007019 | n=7; mediana=-0.00388 [-0.004075; -0.0038]; média=-0.0039; DP=0.0002148 | 0.0004 | 0.1004 | 0.3908 | 0.1133 |
4.2 T1-T4_Abril-2025_GROUP_Z - T2_pos
| variable | label | n_151 | n_452 | grupo_151 | grupo_452 | diferenca_mediana_452_menos_151 | p_wilcoxon | p_wilcoxon_ajustado | p_t |
|---|---|---|---|---|---|---|---|---|---|
| z102 | T3_PBMC/Single Cells/CD3 subset+ P16 subset+ | Freq. of Parent | 8 | 7 | n=8; mediana=2.34 [2.258; 3.05]; média=2.688; DP=0.827 | n=7; mediana=1.93 [1.63; 2.185]; média=2.02; DP=0.5562 | -0.410 | 0.0428 | 0.9811 | 0.0880 |
| z86 | T3_PBMC/Single Cells/Q14: CD3+ , P16+ | Freq. of Parent | 8 | 7 | n=8; mediana=1.875 [1.728; 2.438]; média=2.126; DP=0.6734 | n=7; mediana=1.41 [1.2; 1.645]; média=1.536; DP=0.5155 | -0.465 | 0.0562 | 0.9811 | 0.0775 |
| z4 | T1_PBMC/Single Cells/CD25 subset | Freq. of Parent | 8 | 7 | n=8; mediana=28 [25.38; 30.52]; média=29.21; DP=7.876 | n=7; mediana=25.9 [20.15; 26.15]; média=23.79; DP=3.878 | -2.100 | 0.0823 | 0.9811 | 0.1139 |
| z103 | T3_PBMC/Single Cells/CD3 subset+CD56 subset+P16 subset+ | Freq. of Parent | 8 | 7 | n=8; mediana=1.13 [0.9; 1.288]; média=1.191; DP=0.5991 | n=7; mediana=0.71 [0.67; 0.92]; média=0.8329; DP=0.3696 | -0.420 | 0.1321 | 0.9811 | 0.1836 |
| z78 | T3_PBMC/Single Cells/Q6: CD3+ , CD14+ | Freq. of Parent | 8 | 7 | n=8; mediana=1.885 [1.638; 2.38]; média=2.056; DP=0.7092 | n=7; mediana=1.52 [0.845; 1.9]; média=1.447; DP=0.689 | -0.365 | 0.1480 | 0.9811 | 0.1162 |
| z105 | T3_PBMC/Single Cells/CD3 subset+CD56 subset-P16 subset+ | Freq. of Parent | 8 | 7 | n=8; mediana=1.47 [1.265; 1.805]; média=1.496; DP=0.383 | n=7; mediana=1.28 [0.99; 1.36]; média=1.183; DP=0.2919 | -0.190 | 0.1642 | 0.9811 | 0.0964 |
| z52 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q5: CD4- , CD28+ | Freq. of Parent | 8 | 7 | n=8; mediana=21.75 [17.03; 29.4]; média=22.86; DP=6.689 | n=7; mediana=16.7 [15.9; 21.4]; média=18.83; DP=3.773 | -5.050 | 0.1642 | 0.9811 | 0.1714 |
| z116 | T3_PBMC/Single Cells/CD14 subset-CD16 subset+P16 subset- | Freq. of Parent | 8 | 7 | n=8; mediana=14.8 [12.47; 18.25]; média=14.83; DP=4.712 | n=7; mediana=19.6 [16.6; 20.4]; média=18.19; DP=3.968 | 4.800 | 0.1645 | 0.9811 | 0.1587 |
| z149 | T4_PBMC/Single Cells/C12+-CD14 subset-CD16 subset+ | Freq. of Parent | 8 | 7 | n=8; mediana=22.65 [21.35; 23.62]; média=22.9; DP=4.032 | n=7; mediana=24.9 [22.8; 27.9]; média=25.53; DP=4.114 | 2.250 | 0.1824 | 0.9811 | 0.2353 |
| z112 | T3_PBMC/Single Cells/CD14 subset+CD16 subset+P16 subset- | Freq. of Parent | 8 | 7 | n=8; mediana=1.85 [1.62; 2.448]; média=1.915; DP=0.7214 | n=7; mediana=1.45 [1.295; 1.705]; média=1.447; DP=0.4193 | -0.400 | 0.2026 | 0.9811 | 0.1464 |
| z132 | T4_PBMC/Single Cells/CD16 subset | Freq. of Parent | 8 | 7 | n=8; mediana=39.05 [34.97; 41.78]; média=40.79; DP=8.676 | n=7; mediana=46 [42; 47.5]; média=44.89; DP=6 | 6.950 | 0.2026 | 0.9811 | 0.3031 |
| z145 | T4_PBMC/Single Cells/CD16 subset- | Freq. of Parent | 8 | 7 | n=8; mediana=60.95 [58.23; 65.03]; média=59.21; DP=8.676 | n=7; mediana=54 [52.5; 58]; média=55.11; DP=6 | -6.950 | 0.2026 | 0.9811 | 0.3031 |
| z93 | T3_PBMC/Single Cells/Q21: CD14- , CD16+ | Freq. of Parent | 8 | 7 | n=8; mediana=14.85 [12.35; 18.58]; média=14.8; DP=4.661 | n=7; mediana=18.8 [15.95; 20.2]; média=17.89; DP=3.794 | 3.950 | 0.2243 | 0.9811 | 0.1818 |
| z46 | T2_Lymphocytes/Single Cells | Freq. of Parent | 8 | 7 | n=8; mediana=96.4 [95.2; 97.3]; média=96.08; DP=2.225 | n=7; mediana=94.2 [94.15; 96.3]; média=94.81; DP=2.638 | -2.200 | 0.2463 | 0.9811 | 0.3407 |
| z6 | T1_PBMC/Single Cells/Q1: CD4- , CD8+ | Freq. of Parent | 8 | 7 | n=8; mediana=18.05 [17.18; 19.52]; média=17.85; DP=5.803 | n=7; mediana=21.7 [14.33; 28.85]; média=21.44; DP=10.47 | 3.650 | 0.2716 | 0.9811 | 0.4418 |
| z74 | T3_PBMC/Single Cells/CD16 subset | Freq. of Parent | 8 | 7 | n=8; mediana=23.5 [20.72; 24.35]; média=22.08; DP=4.205 | n=7; mediana=25.3 [21.7; 27.5]; média=24.24; DP=4.832 | 1.800 | 0.3248 | 0.9811 | 0.3753 |
| z99 | T3_PBMC/Single Cells/CD16 subset- | Freq. of Parent | 8 | 7 | n=8; mediana=76.5 [75.65; 79.27]; média=77.92; DP=4.205 | n=7; mediana=74.7 [72.5; 78.3]; média=75.76; DP=4.832 | -1.800 | 0.3248 | 0.9811 | 0.3753 |
| z54 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q7: CD4+ , CD28- | Freq. of Parent | 8 | 7 | n=8; mediana=1.3 [0.81; 2.305]; média=1.599; DP=1.13 | n=7; mediana=1.89 [1.525; 3.035]; média=2.727; DP=2.294 | 0.590 | 0.3253 | 0.9811 | 0.2693 |
| z56 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q9: CD4- , uPAR+ | Freq. of Parent | 8 | 7 | n=8; mediana=1.665 [1.222; 2.037]; média=1.686; DP=0.6148 | n=7; mediana=1.88 [1.63; 2.86]; média=2.163; DP=0.8266 | 0.215 | 0.3253 | 0.9811 | 0.2364 |
| z66 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q19: CD8+ , uPAR- | Freq. of Parent | 8 | 7 | n=8; mediana=29.85 [25.2; 35.67]; média=30.31; DP=9.786 | n=7; mediana=37.8 [26.8; 41.6]; média=34.17; DP=13.23 | 7.950 | 0.3253 | 0.9811 | 0.5386 |
4.3 T1-T6_10-Jun-2026_GROUP_V - T1_baseline
| variable | label | n_151 | n_452 | grupo_151 | grupo_452 | diferenca_mediana_452_menos_151 | p_wilcoxon | p_wilcoxon_ajustado | p_t |
|---|---|---|---|---|---|---|---|---|---|
| v110 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q26: CD8+ , TIM-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=0.68 [0.53; 0.92]; média=1.046; DP=1.032 | n=10; mediana=0.495 [0.3675; 0.7]; média=2.155; DP=5.396 | -0.185 | 0.1180 | 1 | 0.5407 |
| v132 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/P16+ | Freq. of Parent | 7 | 8 | n=7; mediana=0 [0; 0.0095]; média=0.005429; DP=0.009271 | n=8; mediana=0 [0; 0]; média=0; DP=0 | 0.000 | 0.1413 | 1 | 0.1723 |
| v7 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/Q1: CD25- , CD127+ | Median (CD127) | 7 | 8 | n=7; mediana=1063 [1046; 1076]; média=1058; DP=58.47 | n=8; mediana=1122 [1070; 1166]; média=1114; DP=120 | 59.000 | 0.1480 | 1 | 0.2646 |
| v109 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q25: CD8- , TIM-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=5.13 [4.655; 6.145]; média=5.807; DP=3.119 | n=10; mediana=2.365 [1.762; 6.018]; média=7.568; DP=13.21 | -2.765 | 0.1571 | 1 | 0.6932 |
| v63 | T4_C12FDG_PBMC/Single Cells/Q5: C12FDG- , CD3+ | Freq. of Parent | 7 | 8 | n=7; mediana=54.8 [50.3; 57.45]; média=53.97; DP=7.824 | n=8; mediana=63.8 [53.95; 69.58]; média=59.24; DP=14.09 | 9.000 | 0.1832 | 1 | 0.3824 |
| v94 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q10: CD4+ , TIM-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=1.78 [1.59; 2.86]; média=2.987; DP=2.811 | n=10; mediana=0.9 [0.7425; 2.385]; média=4.74; DP=11.01 | -0.880 | 0.1877 | 1 | 0.6400 |
| v126 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 8 | n=7; mediana=63.5 [55.7; 66.75]; média=60.6; DP=7.984 | n=8; mediana=67.35 [61.82; 70.85]; média=66.06; DP=9.569 | 3.850 | 0.2243 | 1 | 0.2497 |
| v105 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q21: CD8- , CTLA-4+ | Freq. of Parent | 7 | 10 | n=7; mediana=0.15 [0.15; 0.165]; média=0.2061; DP=0.1672 | n=10; mediana=0.108 [0.07125; 0.1725]; média=0.1244; DP=0.06792 | -0.042 | 0.2387 | 1 | 0.2584 |
| v77 | T4_C12FDG_PBMC/Single Cells/Q19: C12FDG+ , CD8- | Freq. of Parent | 7 | 8 | n=7; mediana=2.34 [1.61; 2.6]; média=2.464; DP=1.522 | n=8; mediana=1.28 [0.875; 2.175]; média=1.746; DP=1.381 | -1.060 | 0.2467 | 1 | 0.3596 |
| v69 | T4_C12FDG_PBMC/Single Cells/Q11: C12FDG+ , CD14- | Freq. of Parent | 7 | 8 | n=7; mediana=0.61 [0.465; 1.055]; média=0.8771; DP=0.6108 | n=8; mediana=0.45 [0.1925; 0.8225]; média=0.6188; DP=0.5528 | -0.160 | 0.2716 | 1 | 0.4093 |
| v8 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/Q2: CD25+ , CD127+ | Freq. of Parent | 7 | 8 | n=7; mediana=11.2 [10.8; 14.5]; média=12.56; DP=2.828 | n=8; mediana=16.6 [12.77; 19.35]; média=16.06; DP=7.815 | 5.400 | 0.2716 | 1 | 0.2670 |
| v51 | T3_Monocytes_PBMC/Single Cells/Q5: CD56- , CD16+ | Freq. of Parent | 7 | 8 | n=7; mediana=16.7 [15.05; 21.5]; média=18.79; DP=6.294 | n=8; mediana=15.05 [10.9; 19.9]; média=15.13; DP=5.534 | -1.650 | 0.2968 | 1 | 0.2582 |
| v84 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 10 | n=7; mediana=56.1 [52.7; 60.35]; média=56.83; DP=7.416 | n=10; mediana=63.15 [53.5; 69.75]; média=61.79; DP=11.39 | 7.050 | 0.3052 | 1 | 0.2942 |
| v93 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q9: CD4- , TIM-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=2.9 [2.13; 3.145]; média=2.621; DP=1.084 | n=10; mediana=1.42 [0.785; 3.11]; média=3.58; DP=5.654 | -1.480 | 0.3055 | 1 | 0.6127 |
| v134 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q2: CD4+ , CD8+ | Freq. of Parent | 7 | 8 | n=7; mediana=0.9 [0.52; 0.98]; média=0.9771; DP=0.78 | n=8; mediana=0.515 [0.3725; 0.6125]; média=0.9988; DP=1.568 | -0.385 | 0.3253 | 1 | 0.9732 |
| v59 | T4_C12FDG_PBMC/Single Cells/Q1: C12FDG- , FSC-A+ | Freq. of Parent | 7 | 8 | n=7; mediana=1.25 [1.02; 1.46]; média=1.193; DP=0.5587 | n=8; mediana=1.055 [0.9175; 1.135]; média=1.051; DP=0.3183 | -0.195 | 0.3253 | 1 | 0.5682 |
| v67 | T4_C12FDG_PBMC/Single Cells/Q9: C12FDG- , CD14+ | Freq. of Parent | 7 | 8 | n=7; mediana=3.25 [2.87; 4.06]; média=3.656; DP=1.578 | n=8; mediana=2.475 [1.568; 3.578]; média=3.15; DP=2.587 | -0.775 | 0.3253 | 1 | 0.6518 |
| v72 | T4_C12FDG_PBMC/Single Cells/Q14: C12FDG+ , CD4+ | Freq. of Parent | 7 | 8 | n=7; mediana=12 [10.32; 14.25]; média=11.62; DP=4.967 | n=8; mediana=7.605 [5.61; 11.54]; média=10.2; DP=8.241 | -4.395 | 0.3253 | 1 | 0.6890 |
| v76 | T4_C12FDG_PBMC/Single Cells/Q18: C12FDG+ , CD8+ | Freq. of Parent | 7 | 8 | n=7; mediana=9.3 [7.405; 13.6]; média=9.817; DP=5.166 | n=8; mediana=6.42 [4.642; 9.988]; média=8.884; DP=7.903 | -2.880 | 0.3253 | 1 | 0.7888 |
| v117 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q33: CD8- , PD-1+ | Freq. of Parent | 7 | 10 | n=7; mediana=2.24 [1.88; 2.825]; média=2.387; DP=0.9661 | n=10; mediana=1.815 [0.9425; 2.262]; média=2.132; DP=1.546 | -0.425 | 0.3539 | 1 | 0.6818 |
4.4 T1-T6_10-Jun-2026_GROUP_V - T2_pos
| variable | label | n_151 | n_452 | grupo_151 | grupo_452 | diferenca_mediana_452_menos_151 | p_wilcoxon | p_wilcoxon_ajustado | p_t |
|---|---|---|---|---|---|---|---|---|---|
| v106 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q22: CD8+ , CTLA-4+ | Freq. of Parent | 7 | 12 | n=7; mediana=0.021 [0.014; 0.0265]; média=0.02; DP=0.01214 | n=12; mediana=0.00666 [0; 0.0125]; média=0.00819; DP=0.007797 | -0.0143 | 0.0296 | 1 | 0.0463 |
| v69 | T4_C12FDG_PBMC/Single Cells/Q11: C12FDG+ , CD14- | Freq. of Parent | 7 | 9 | n=7; mediana=0.95 [0.785; 1.63]; média=1.249; DP=0.6831 | n=9; mediana=0.65 [0.39; 0.83]; média=0.6867; DP=0.4083 | -0.3000 | 0.0567 | 1 | 0.0854 |
| v52 | T3_Monocytes_PBMC/Single Cells/Q6: CD56+ , CD16+ | Freq. of Parent | 7 | 10 | n=7; mediana=2.39 [1.515; 3.895]; média=2.734; DP=1.527 | n=10; mediana=1.225 [0.97; 1.91]; média=1.504; DP=0.8211 | -1.1650 | 0.1073 | 1 | 0.0859 |
| v25 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 10 | n=7; mediana=53.4 [48.95; 54.05]; média=51.47; DP=6.728 | n=10; mediana=61.5 [51.47; 65.9]; média=58.72; DP=10.47 | 8.1000 | 0.1304 | 1 | 0.1030 |
| v58 | T4_C12FDG_PBMC/Single Cells | Freq. of Parent | 7 | 9 | n=7; mediana=97.5 [96.7; 97.7]; média=97.3; DP=0.8679 | n=9; mediana=96.7 [95.5; 97.3]; média=96.36; DP=1.248 | -0.8000 | 0.1378 | 1 | 0.0965 |
| v101 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q17: CD4- , PD-1+ | Freq. of Parent | 7 | 12 | n=7; mediana=0.67 [0.565; 1.3]; média=0.9343; DP=0.4873 | n=12; mediana=0.535 [0.3775; 0.8925]; média=0.8067; DP=0.7901 | -0.1350 | 0.1761 | 1 | 0.6688 |
| v75 | T4_C12FDG_PBMC/Single Cells/Q17: C12FDG- , CD8+ | Freq. of Parent | 7 | 9 | n=7; mediana=18.8 [15.9; 20.5]; média=18.46; DP=3.013 | n=9; mediana=21 [19.4; 23.9]; média=20.36; DP=5.504 | 2.2000 | 0.1851 | 1 | 0.3936 |
| v77 | T4_C12FDG_PBMC/Single Cells/Q19: C12FDG+ , CD8- | Freq. of Parent | 7 | 9 | n=7; mediana=2.21 [2.045; 2.945]; média=2.596; DP=0.9803 | n=9; mediana=2.1 [1.5; 2.12]; média=2.171; DP=1.212 | -0.1100 | 0.1851 | 1 | 0.4514 |
| v59 | T4_C12FDG_PBMC/Single Cells/Q1: C12FDG- , FSC-A+ | Freq. of Parent | 7 | 9 | n=7; mediana=0.97 [0.8; 1.255]; média=1.24; DP=0.8712 | n=9; mediana=1.3 [1.15; 1.56]; média=1.381; DP=0.4159 | 0.3300 | 0.1855 | 1 | 0.7031 |
| v31 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/uPAR+ | Freq. of Parent | 7 | 10 | n=7; mediana=35.6 [30.85; 38]; média=33.46; DP=7.717 | n=10; mediana=26.8 [20.42; 31.9]; média=25.39; DP=11.9 | -8.8000 | 0.1874 | 1 | 0.1109 |
| v32 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+/uPAR- | Freq. of Parent | 7 | 10 | n=7; mediana=64.4 [62; 69.15]; média=66.54; DP=7.717 | n=10; mediana=73.2 [68.1; 79.58]; média=74.61; DP=11.9 | 8.8000 | 0.1874 | 1 | 0.1108 |
| v47 | T3_Monocytes_PBMC/Single Cells/Q1: CD14- , CD16+ | Freq. of Parent | 7 | 10 | n=7; mediana=11.2 [10.65; 17.5]; média=14.21; DP=5.79 | n=10; mediana=9.54 [7.018; 15.6]; média=11.05; DP=4.885 | -1.6600 | 0.1877 | 1 | 0.2618 |
| v120 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q36: CD8- , PD-1- | Freq. of Parent | 7 | 12 | n=7; mediana=73.5 [69.55; 73.95]; média=71.23; DP=4.077 | n=12; mediana=68.2 [63.02; 70.68]; média=68.04; DP=8.592 | -5.3000 | 0.2200 | 1 | 0.2907 |
| v111 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q27: CD8+ , TIM-3- | Freq. of Parent | 7 | 12 | n=7; mediana=21.2 [18.6; 23.55]; média=21.79; DP=3.924 | n=12; mediana=26.8 [20.45; 29.98]; média=24.83; DP=9.49 | 5.6000 | 0.2204 | 1 | 0.3432 |
| v84 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 12 | n=7; mediana=54.5 [51.85; 55.1]; média=52.91; DP=6.363 | n=12; mediana=57.8 [51.85; 68.23]; média=58.02; DP=13.07 | 3.3000 | 0.2204 | 1 | 0.2703 |
| v3 | T1_Treg_PBMC/Single Cells | Freq. of Parent | 7 | 10 | n=7; mediana=96.7 [95.95; 96.75]; média=96.04; DP=1.52 | n=10; mediana=95.45 [93.78; 96.45]; média=95.17; DP=1.451 | -1.2500 | 0.2211 | 1 | 0.2570 |
| v126 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 10 | n=7; mediana=58.1 [48.75; 59.45]; média=54.59; DP=7.495 | n=10; mediana=60.65 [55.12; 69.25]; média=60.38; DP=10.42 | 2.5500 | 0.2225 | 1 | 0.2024 |
| v119 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q35: CD8+ , PD-1- | Freq. of Parent | 7 | 12 | n=7; mediana=23.1 [21.15; 27.05]; média=24.33; DP=3.844 | n=12; mediana=29.4 [23; 32.67]; média=27.41; DP=10.25 | 6.3000 | 0.2365 | 1 | 0.3651 |
| v116 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q32: CD8- , LAG-3- | Freq. of Parent | 7 | 12 | n=7; mediana=78.4 [75.5; 81.3]; média=77.99; DP=4.034 | n=12; mediana=73.6 [69.5; 78.62]; média=74.81; DP=8.953 | -4.8000 | 0.2539 | 1 | 0.3051 |
| v85 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+ | Freq. of Parent | 7 | 12 | n=7; mediana=19 [16.25; 21.75]; média=19.27; DP=3.494 | n=12; mediana=23.9 [18.7; 26.62]; média=22.24; DP=8.521 | 4.9000 | 0.2539 | 1 | 0.3041 |
5 Variação T2 - T1 entre grupos
Esta é a comparação diretamente ligada à pergunta “qual grupo foi
mais modificado pela intervenção”. Para cada indivíduo e variável,
calcula-se delta = T2 - T1; depois os deltas são comparados
entre os grupos.
5.1 T1-T4_Abril-2025_GROUP_Z
| variable | label | n_151 | n_452 | delta_151 | delta_452 | diferenca_delta_mediana_452_menos_151 | p_wilcoxon_delta | p_wilcoxon_delta_ajustado | p_t_delta |
|---|---|---|---|---|---|---|---|---|---|
| z3 | T1_PBMC/Single Cells/CD3 subset | Freq. of Parent | 5 | 7 | n=5; mediana=-1.1 [-8.3; -1]; média=-5.54; DP=8.513 | n=7; mediana=3.2 [2.9; 5.1]; média=3.614; DP=2.49 | 4.30 | 0.0094 | 0.4813 | 0.0727 |
| z129 | T4_PBMC/Single Cells/CD3 subset | Freq. of Parent | 5 | 7 | n=5; mediana=-1.2 [-1.8; 0.6]; média=-1.58; DP=2.93 | n=7; mediana=7.9 [2.55; 7.95]; média=5.5; DP=4.026 | 9.10 | 0.0149 | 0.4813 | 0.0055 |
| z134 | T4_PBMC/Single Cells/Q2: CD3+ , CD4+ | Freq. of Parent | 5 | 7 | n=5; mediana=-3 [-3.6; 0.2]; média=-2.72; DP=4.226 | n=7; mediana=3.9 [3.5; 5.8]; média=4.086; DP=3.308 | 6.90 | 0.0149 | 0.4813 | 0.0188 |
| z142 | T4_PBMC/Single Cells/CD3 subset- | Freq. of Parent | 5 | 7 | n=5; mediana=1.2 [-0.6; 1.8]; média=1.58; DP=2.93 | n=7; mediana=-7.9 [-7.95; -2.55]; média=-5.5; DP=4.026 | -9.10 | 0.0149 | 0.4813 | 0.0055 |
| z136 | T4_PBMC/Single Cells/Q4: CD3- , CD4- | Freq. of Parent | 5 | 7 | n=5; mediana=2 [-1.4; 3.3]; média=1.3; DP=3.188 | n=7; mediana=-3.6 [-8; -2.5]; média=-5.029; DP=3.811 | -5.60 | 0.0230 | 0.4813 | 0.0113 |
| z45 | T2_Lymphocytes | Freq. of Parent | 5 | 7 | n=5; mediana=2.6 [2.5; 7.8]; média=5.66; DP=4.702 | n=7; mediana=-5.2 [-5.75; -2.9]; média=-2.457; DP=6.398 | -7.80 | 0.0344 | 0.4813 | 0.0298 |
| z70 | T3_PBMC | Freq. of Parent | 5 | 7 | n=5; mediana=3.7 [2.5; 4.5]; média=3.32; DP=1.775 | n=7; mediana=-1.3 [-1.5; -0.35]; média=-0.2429; DP=2.479 | -5.00 | 0.0416 | 0.4813 | 0.0158 |
| z47 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset | Freq. of Parent | 5 | 7 | n=5; mediana=-1.6 [-4.3; 0.8]; média=-3.8; DP=9.106 | n=7; mediana=6.7 [2.9; 8.35]; média=5.643; DP=4.688 | 8.30 | 0.0513 | 0.4813 | 0.0816 |
| z149 | T4_PBMC/Single Cells/C12+-CD14 subset-CD16 subset+ | Freq. of Parent | 5 | 7 | n=5; mediana=1.2 [1.2; 2.1]; média=2.54; DP=4.026 | n=7; mediana=-1.4 [-2.15; -0.55]; média=-0.8857; DP=2.753 | -2.60 | 0.0735 | 0.4813 | 0.1459 |
| z1 | z1 | 5 | 7 | n=5; mediana=3.3 [2; 7]; média=3.62; DP=3.853 | n=7; mediana=-4.8 [-6; -2.1]; média=-2.614; DP=6.301 | -8.10 | 0.0740 | 0.4813 | 0.0603 |
| z123 | T4_PBMC | Median (C12) | 5 | 7 | n=5; mediana=-179 [-208; 9]; média=-181.4; DP=258.2 | n=7; mediana=47 [33.5; 135.5]; média=83.14; DP=94.38 | 226.00 | 0.0740 | 0.4813 | 0.0828 |
| z146 | T4_PBMC/Single Cells/C12+ CD3 subset+ CD4 subset+ | Freq. of Parent | 5 | 7 | n=5; mediana=-5.3 [-7.11; 0.26]; média=-5.454; DP=8.767 | n=7; mediana=2.17 [1.64; 5.175]; média=3.741; DP=3.734 | 7.47 | 0.0740 | 0.4813 | 0.0779 |
| z148 | T4_PBMC/Single Cells/C12+-CD14 subset+CD16 subset- | Freq. of Parent | 5 | 7 | n=5; mediana=1.27 [0.75; 2.38]; média=1.346; DP=1.794 | n=7; mediana=0.06 [-2.1; 0.41]; média=-0.5914; DP=1.739 | -1.21 | 0.0740 | 0.4813 | 0.0961 |
| z4 | T1_PBMC/Single Cells/CD25 subset | Freq. of Parent | 5 | 7 | n=5; mediana=0.7 [-1.4; 6.4]; média=4.04; DP=10.29 | n=7; mediana=-4.1 [-7.6; -2.2]; média=-5.457; DP=4.946 | -4.80 | 0.0740 | 0.4813 | 0.1104 |
| z52 | T2_Lymphocytes/Single Cells/CD3, FSC-A subset/Q5: CD4- , CD28+ | Freq. of Parent | 5 | 7 | n=5; mediana=-2.4 [-2.6; 0.1]; média=-1.8; DP=2.046 | n=7; mediana=2 [-0.4; 2.8]; média=1.014; DP=2.635 | 4.40 | 0.0740 | 0.4813 | 0.0645 |
| z124 | T4_PBMC/C12, FSC-A high | Freq. of Parent | 5 | 7 | n=5; mediana=-11.2 [-13.1; 1.7]; média=-11.3; DP=19.96 | n=7; mediana=4.6 [2.3; 8.9]; média=7.427; DP=10.41 | 15.80 | 0.1044 | 0.4813 | 0.1071 |
| z127 | T4_PBMC/Single Cells/C12+ | Freq. of Parent | 5 | 7 | n=5; mediana=-9.5 [-14; 1.26]; média=-9.768; DP=16.5 | n=7; mediana=3.4 [1.35; 6.85]; média=4.856; DP=7.492 | 12.90 | 0.1044 | 0.4813 | 0.1214 |
| z128 | T4_PBMC/Single Cells/C12- | Freq. of Parent | 5 | 7 | n=5; mediana=9.5 [-1.3; 14]; média=9.76; DP=16.51 | n=7; mediana=-3.4 [-6.85; -1.35]; média=-4.857; DP=7.495 | -12.90 | 0.1044 | 0.4813 | 0.1216 |
| z141 | T4_PBMC/Single Cells/C12+- | Freq. of Parent | 5 | 7 | n=5; mediana=9.5 [-1.3; 14]; média=9.76; DP=16.51 | n=7; mediana=-3.4 [-6.85; -1.35]; média=-4.857; DP=7.495 | -12.90 | 0.1044 | 0.4813 | 0.1216 |
| z152 | T4_PBMC/Single Cells/C12+CD14 subset+CD16 subset- | Freq. of Parent | 5 | 7 | n=5; mediana=-1.8 [-4.75; 0.29]; média=-2.08; DP=3.67 | n=7; mediana=1.09 [0.585; 2.395]; média=1.237; DP=2.425 | 2.89 | 0.1044 | 0.4813 | 0.1245 |
| z125 | T4_PBMC/Single Cells | Freq. of Parent | 5 | 7 | n=5; mediana=0.2 [0.1; 0.3]; média=0.14; DP=0.4722 | n=7; mediana=-0.6 [-0.7; -0.15]; média=-0.3571; DP=0.6051 | -0.80 | 0.1410 | 0.4813 | 0.1418 |
| z114 | T3_PBMC/Single Cells/CD14 subset+CD16 subset-P16 subset- | Freq. of Parent | 5 | 7 | n=5; mediana=0.47 [0.23; 0.68]; média=0.248; DP=2.077 | n=7; mediana=-0.45 [-2.43; 0.01]; média=-1.086; DP=2.337 | -0.92 | 0.1439 | 0.4813 | 0.3242 |
| z130 | T4_PBMC/Single Cells/CD4 subset | Freq. of Parent | 5 | 7 | n=5; mediana=-3.7 [-5.4; 1.7]; média=-1.92; DP=4.577 | n=7; mediana=2.6 [0.65; 4.7]; média=2.957; DP=3.373 | 6.30 | 0.1439 | 0.4813 | 0.0828 |
| z143 | T4_PBMC/Single Cells/CD4 subset- | Freq. of Parent | 5 | 7 | n=5; mediana=3.7 [-1.7; 5.4]; média=1.92; DP=4.577 | n=7; mediana=-2.6 [-4.7; -0.65]; média=-2.957; DP=3.373 | -6.30 | 0.1439 | 0.4813 | 0.0828 |
| z122 | T4_PBMC | Freq. of Parent | 5 | 7 | n=5; mediana=1.7 [1; 3.2]; média=2.5; DP=2.132 | n=7; mediana=-0.8 [-2.15; 1.65]; média=0.1; DP=3.133 | -2.50 | 0.1667 | 0.4813 | 0.1455 |
5.2 T1-T6_10-Jun-2026_GROUP_V
| variable | label | n_151 | n_452 | delta_151 | delta_452 | diferenca_delta_mediana_452_menos_151 | p_wilcoxon_delta | p_wilcoxon_delta_ajustado | p_t_delta |
|---|---|---|---|---|---|---|---|---|---|
| v69 | T4_C12FDG_PBMC/Single Cells/Q11: C12FDG+ , CD14- | Freq. of Parent | 7 | 7 | n=7; mediana=0.34 [0.275; 0.35]; média=0.3714; DP=0.2426 | n=7; mediana=0.06 [-0.14; 0.135]; média=-0.01429; DP=0.3255 | -0.2800 | 0.0297 | 1 | 0.0286 |
| v106 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q22: CD8+ , CTLA-4+ | Freq. of Parent | 7 | 10 | n=7; mediana=0.006 [0.001; 0.0135]; média=0.00593; DP=0.009411 | n=10; mediana=-0.003085 [-0.01348; 0]; média=-0.005381; DP=0.009048 | -0.0091 | 0.0354 | 1 | 0.0281 |
| v12 | T1_Treg_PBMC/Single Cells/CD3, FSC-A subset/Q2: CD4+ , CD8+ | Freq. of Parent | 7 | 8 | n=7; mediana=-0.15 [-0.305; -0.005]; média=-0.1943; DP=0.3496 | n=8; mediana=0.26 [0.0075; 0.7425]; média=0.2025; DP=0.6939 | 0.4100 | 0.0728 | 1 | 0.1832 |
| v26 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+ | Freq. of Parent | 7 | 8 | n=7; mediana=-2.3 [-4.75; -0.55]; média=-2.614; DP=3.214 | n=8; mediana=0.05 [-0.925; 2.725]; média=0.9912; DP=4.74 | 2.3500 | 0.0823 | 1 | 0.1064 |
| v85 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+ | Freq. of Parent | 7 | 10 | n=7; mediana=-1.4 [-6.1; -0.45]; média=-3.129; DP=3.516 | n=10; mediana=0.55 [-1.775; 1.6]; média=-0.196; DP=4.352 | 1.9500 | 0.1071 | 1 | 0.1467 |
| v120 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q36: CD8- , PD-1- | Freq. of Parent | 7 | 10 | n=7; mediana=0.5 [-0.8; 2.1]; média=1.114; DP=4.057 | n=10; mediana=-1.65 [-4.1; -0.025]; média=-2.08; DP=3.825 | -2.1500 | 0.1073 | 1 | 0.1268 |
| v90 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q6: CD4+ , CTLA-4+ | Freq. of Parent | 7 | 10 | n=7; mediana=-0.06 [-0.145; -0.025]; média=-0.2486; DP=0.4812 | n=10; mediana=0.26 [-0.205; 0.4775]; média=0.148; DP=0.5074 | 0.3200 | 0.1073 | 1 | 0.1251 |
| v116 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q32: CD8- , LAG-3- | Freq. of Parent | 7 | 10 | n=7; mediana=0.8 [-0.35; 5.35]; média=2.586; DP=3.736 | n=10; mediana=-0.5 [-1.575; 0.45]; média=-0.34; DP=4.514 | -1.3000 | 0.1430 | 1 | 0.1665 |
| v142 | T6_P16_H2AX_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 7 | 8 | n=7; mediana=7.9 [6.545; 10.35]; média=8.699; DP=4.608 | n=8; mediana=2.75 [-0.7525; 7.175]; média=7.204; DP=21.62 | -5.1500 | 0.1480 | 1 | 0.8537 |
| v25 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset | Freq. of Parent | 7 | 8 | n=7; mediana=-9.1 [-10.45; -4.7]; média=-6.457; DP=6.921 | n=8; mediana=-6.95 [-7.85; 3]; média=-2.238; DP=9.321 | 2.1500 | 0.1480 | 1 | 0.3346 |
| v111 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q27: CD8+ , TIM-3- | Freq. of Parent | 7 | 10 | n=7; mediana=-1.4 [-4.5; 1.05]; média=-2.143; DP=3.611 | n=10; mediana=1 [-0.425; 2.5]; média=1.636; DP=5.97 | 2.4000 | 0.1568 | 1 | 0.1259 |
| v108 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q24: CD8- , CTLA-4- | Freq. of Parent | 7 | 10 | n=7; mediana=1.2 [0.15; 5.45]; média=2.857; DP=3.518 | n=10; mediana=-0.4 [-1.875; 1.575]; média=0.03; DP=4.848 | -1.6000 | 0.1716 | 1 | 0.1840 |
| v27 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q1: CD4- , CD8+ | Median (uPAR) | 7 | 8 | n=7; mediana=155 [130.5; 430]; média=223.9; DP=238.9 | n=8; mediana=54.5 [-37.25; 211.2]; média=62.62; DP=220.8 | -100.5000 | 0.1832 | 1 | 0.2009 |
| v115 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q31: CD8+ , LAG-3- | Freq. of Parent | 7 | 10 | n=7; mediana=-1.1 [-5.45; -0.15]; média=-2.829; DP=3.508 | n=10; mediana=0.35 [-1.7; 1.825]; média=-0.093; DP=4.743 | 1.4500 | 0.1874 | 1 | 0.1920 |
| v107 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q23: CD8+ , CTLA-4- | Freq. of Parent | 7 | 10 | n=7; mediana=-1 [-5.55; -0.1]; média=-2.829; DP=3.593 | n=10; mediana=0.35 [-1.675; 1.9]; média=-0.078; DP=4.79 | 1.3500 | 0.1877 | 1 | 0.1966 |
| v88 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 7 | 10 | n=7; mediana=9.9 [2.25; 16.65]; média=9.186; DP=8.056 | n=10; mediana=0.495 [-4.875; 5.65]; média=3.839; DP=14.5 | -9.4050 | 0.1877 | 1 | 0.3474 |
| v105 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q21: CD8- , CTLA-4+ | Freq. of Parent | 7 | 10 | n=7; mediana=-0.01 [-0.0765; 0.02]; média=-0.01043; DP=0.1238 | n=10; mediana=0.04 [-0.02125; 0.06525]; média=0.0196; DP=0.06972 | 0.0500 | 0.2040 | 1 | 0.5764 |
| v119 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q35: CD8+ , PD-1- | Freq. of Parent | 7 | 10 | n=7; mediana=-1.7 [-4.3; 0.2]; média=-2.443; DP=3.533 | n=10; mediana=-0.2 [-1.125; 2.4]; média=0.337; DP=4.841 | 1.5000 | 0.2225 | 1 | 0.1914 |
| v3 | T1_Treg_PBMC/Single Cells | Freq. of Parent | 7 | 8 | n=7; mediana=1 [-0.6; 1.65]; média=0.2429; DP=1.95 | n=8; mediana=-0.8 [-1.55; 0.275]; média=-0.65; DP=1.28 | -1.8000 | 0.2243 | 1 | 0.3259 |
| v41 | T2_Senescence_PBMC/Single Cells/CD3, FSC-A subset/Q4: CD4- , CD8- | Freq. of Parent | 7 | 8 | n=7; mediana=8 [3.255; 9.745]; média=6.114; DP=5.407 | n=8; mediana=1.5 [0.07; 6.75]; média=3.835; DP=8.759 | -6.5000 | 0.2716 | 1 | 0.5507 |
| v52 | T3_Monocytes_PBMC/Single Cells/Q6: CD56+ , CD16+ | Freq. of Parent | 7 | 8 | n=7; mediana=0.44 [-0.835; 1.135]; média=0.3471; DP=1.305 | n=8; mediana=-0.48 [-1.145; -0.3375]; média=-1.581; DP=2.721 | -0.9200 | 0.2716 | 1 | 0.1038 |
| v110 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q26: CD8+ , TIM-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=-0.3 [-0.46; -0.14]; média=-0.4871; DP=0.8876 | n=10; mediana=0.018 [-0.27; 0.225]; média=-1.601; DP=5.209 | 0.3180 | 0.3055 | 1 | 0.5228 |
| v114 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q30: CD8+ , LAG-3+ | Freq. of Parent | 7 | 10 | n=7; mediana=-0.01 [-0.0155; 0.039]; média=0.01086; DP=0.05175 | n=10; mediana=-0.027 [-0.07225; 0.01875]; média=-2e-04; DP=0.1631 | -0.0170 | 0.3055 | 1 | 0.8446 |
| v95 | T5_Exhaustion_PBMC/Single Cells/CD3, FSC-A subset/Q11: CD4+ , TIM-3- | Freq. of Parent | 7 | 10 | n=7; mediana=-7.4 [-13.1; 0.9]; média=-5.829; DP=9.305 | n=10; mediana=1 [-7.425; 8.55]; média=-1.27; DP=14.66 | 8.4000 | 0.3055 | 1 | 0.4457 |
| v58 | T4_C12FDG_PBMC/Single Cells | Freq. of Parent | 7 | 7 | n=7; mediana=0.5 [-0.45; 0.8]; média=0.5286; DP=1.643 | n=7; mediana=-0.8 [-1; 0.3]; média=-0.4143; DP=0.9406 | -1.3000 | 0.3062 | 1 | 0.2183 |
6 Arquivos gerados
O relatório salvou as tabelas completas em:
results/resultados_citometria_taurina.xlsxresults/tempo_T1_vs_T2.csvresults/grupos_por_tempo.csvresults/delta_entre_grupos.csv
Os gráficos principais foram salvos na pasta
figures/.
7 Observações metodológicas
- As análises usam pares completos por variável. Um indivíduo pode entrar em uma variável e ser excluído de outra se faltar T1 ou T2 naquela variável.
- Os valores percentuais foram convertidos para escala percentual: por
exemplo,
81,4 %vira81.4. - A direção clínica de “melhora” não foi imposta no código, pois ela
depende da interpretação biológica de cada marcador. O relatório mostra
o sinal e a magnitude de
T2 - T1; a interpretação deve ser aplicada marcador a marcador. - Como muitas variáveis são testadas, os valores de
pajustados devem ser considerados para triagem. Resultados com amostras muito pequenas devem ser interpretados como exploratórios.
## R version 4.5.3 (2026-03-11)
## Platform: aarch64-apple-darwin20
## Running under: macOS Tahoe 26.5.1
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## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; LAPACK version 3.12.1
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## time zone: America/Sao_Paulo
## tzcode source: internal
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## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
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## other attached packages:
## [1] writexl_1.5.4 broom_1.0.13 knitr_1.51 ggplot2_4.0.3 purrr_1.2.2
## [6] stringr_1.6.0 tidyr_1.3.2 dplyr_1.2.1 readxl_1.5.0
##
## loaded via a namespace (and not attached):
## [1] gtable_0.3.6 jsonlite_2.0.0 compiler_4.5.3 tidyselect_1.2.1
## [5] jquerylib_0.1.4 textshaping_1.0.5 systemfonts_1.3.2 scales_1.4.0
## [9] yaml_2.3.12 fastmap_1.2.0 R6_2.6.1 labeling_0.4.3
## [13] generics_0.1.4 backports_1.5.1 tibble_3.3.1 RColorBrewer_1.1-3
## [17] bslib_0.11.0 pillar_1.11.1 rlang_1.2.0 cachem_1.1.0
## [21] stringi_1.8.7 xfun_0.58 S7_0.2.2 sass_0.4.10
## [25] otel_0.2.0 cli_3.6.6 withr_3.0.2 magrittr_2.0.5
## [29] digest_0.6.39 grid_4.5.3 rstudioapi_0.19.0 lifecycle_1.0.5
## [33] vctrs_0.7.3 evaluate_1.0.5 glue_1.8.1 farver_2.1.2
## [37] cellranger_1.1.0 ragg_1.5.2 rmarkdown_2.31 tools_4.5.3
## [41] pkgconfig_2.0.3 htmltools_0.5.9