Clasificación de observaciones mediante métricas de distancia en espacios multivariados: el caso de la distancia de Mahalanobis para la evaluación de biomarcadores de Diabetes Tipo 2.
Gerardo Paredes
2026-05-13
##
## Adjuntando el paquete: 'dplyr'## The following object is masked from 'package:kableExtra':
##
## group_rows## The following objects are masked from 'package:stats':
##
## filter, lag## The following objects are masked from 'package:base':
##
## intersect, setdiff, setequal, union##
## Adjuntando el paquete: 'mice'## The following object is masked from 'package:stats':
##
## filter## The following objects are masked from 'package:base':
##
## cbind, rbindBaseline
Importar Baseline
Corrección de la base
#Convertir columnas chr a num
# HDL, tiene decimales periódicos y un dato con espacio
Baseline_original$`HDL-C (mM)` <-
as.numeric(
trimws(Baseline_original$`HDL-C (mM)`)
)
# D-BIL, tiene decimales periódicos y un dato con puntos de más
Baseline_original$`D-BIL (uM)` <-
as.numeric(
gsub(
"\\.$",
"",
trimws(Baseline_original$`D-BIL (uM)`)
)
)
sum(is.na(Baseline_original$`HDL-C (mM)`))## [1] 0## [1] 0## [1] 0Outliers Baseline
baseline <- Baseline_original
# Diccionario de nombres
diccionario = c(
Gender = "Sexo",
Group = "Grupo",
Age = "Edad",
Height = "Altura",
Weight = "Peso",
BMI = "Índice de masa corporal (kg/m²)",
`Waistline (cm)` = "Circunferencia de cintura (cm)",
`SBP (mmHg)` = "Presión sistólica (mm Hg)",
`DBP (mmHg)` = "Presión diastólica (mm Hg)",
`HBA (%)` = "Hemoglobina A1c (%)",
`FBG (mM)` = "Glucosa en ayunas (mM)",
`ALT (U/L)` = "Alanina aminotransferasa (U/L)",
`AST (U/L)` = "Aspartato aminotransferasa (U/L)",
`Urea (mM)` = "Urea (mM)",
`Cre (uM)` = "Creatinina (µM)",
`UA (uM)` = "Ácido úrico (µM)",
`ALB (g/L)` = "Albúmina (g/L)",
`TC (mM)` = "Colesterol total (mM)",
`TG (mM)` = "Triglicéridos (mM)",
`HDL-C (mM)` = "Colesterol HDL (mM)",
`LDL-C (mM)` = "Colesterol LDL (mM)",
`ALP (U/L)` = "Fosfatasa alcalina (U/L)",
#`Υ-GT (U/L)` = "Gamma-GT (U/L)",
`T-BIL (uM)` = "Bilirrubina total (µM)",
`D-BIL (uM)` = "Bilirrubina directa (µM)",
`TBA (uM)` = "Ácidos biliares totales (µM)",
`CHE (U/L)` = "Colinesterasa (U/L)",
`WBC (10^9/L)` = "Leucocitos (10^9/L)",
`NEUT (%)` = "Neutrófilos (%)",
`LYMPH (%)` = "Linfocitos (%)",
`EO (%)` = "Eosinófilos (%)",
`BASO (%)` = "Basófilos (%)"
)
# Renombrar variables usando el diccionario
nombres_originales = names(baseline)
nombres_nuevos = sapply(nombres_originales, function(nombre) {
if (nombre %in% names(diccionario)) {
diccionario[[nombre]]
} else {
nombre # conservar si no está en el diccionario
}
})
names(baseline) = nombres_nuevos
# variables continuas y categóricas
vars_continuas <- c("Edad", "Altura", "Peso", "Índice de masa corporal (kg/m²)",
"Circunferencia de cintura (cm)", "Presión sistólica (mm Hg)",
"Presión diastólica (mm Hg)", "Glucosa en ayunas (mM)",
"Colesterol total (mM)", "Triglicéridos (mM)",
"Colesterol HDL (mM)", "Colesterol LDL (mM)",
"Alanina aminotransferasa (U/L)", "Aspartato aminotransferasa (U/L)",
"Urea (mM)", "Creatinina (µM)", "Ácido úrico (µM)", "Albúmina (g/L)",
"Fosfatasa alcalina (U/L)", "Bilirrubina total (µM)",
"Bilirrubina directa (µM)", "Ácidos biliares totales (µM)",
"Colinesterasa (U/L)", "Leucocitos (10^9/L)", "Υ-GT (U/L)")
vars_categoricas <- c("Sexo")
vars_edad <- "Edad categorizada"
vars_porcentuales <- c("Neutrófilos (%)","Linfocitos (%)","Eosinófilos (%)","Basófilos (%)", "Hemoglobina A1c (%)")
vars_explorar <- c(vars_continuas, vars_porcentuales)
# Recorrer cada variable continua
for (var in vars_explorar) {
# Asegurarse de que los datos sean numéricos y sin NA
b <- suppressWarnings(as.numeric(baseline[[var]]))
b <- na.omit(b)
if (length(b) > 0) {
cat("\n=============================\n")
cat("Variable:", var, "\n")
cat("-----------------------------\n")
# 5 valores más bajos
cat("5 valores más bajos:\n")
print(head(sort(b), 5))
# 5 valores más altos
cat("5 valores más altos:\n")
print(tail(sort(b), 5))
cat("=============================\n")
} else {
cat("\nVariable:", var, "no tiene datos numéricos válidos.\n")
}
}##
## =============================
## Variable: Edad
## -----------------------------
## 5 valores más bajos:
## [1] 20 25 26 27 27
## 5 valores más altos:
## [1] 69 69 72 72 74
## =============================
##
## =============================
## Variable: Altura
## -----------------------------
## 5 valores más bajos:
## [1] 145 147 153 153 153
## 5 valores más altos:
## [1] 188.0 189.0 190.0 192.0 196.5
## =============================
##
## =============================
## Variable: Peso
## -----------------------------
## 5 valores más bajos:
## [1] 41.1 43.5 44.0 44.3 44.6
## 5 valores más altos:
## [1] 109.3 111.7 112.2 113.4 128.9
## =============================
##
## =============================
## Variable: Índice de masa corporal (kg/m²)
## -----------------------------
## 5 valores más bajos:
## [1] 15.50457 16.34429 16.67410 17.04986 17.09975
## 5 valores más altos:
## [1] 36.22159 36.29226 39.78999 39.95244 40.33929
## =============================
##
## =============================
## Variable: Circunferencia de cintura (cm)
## -----------------------------
## 5 valores más bajos:
## [1] 59 59 59 59 60
## 5 valores más altos:
## [1] 109 110 111 117 123
## =============================
##
## =============================
## Variable: Presión sistólica (mm Hg)
## -----------------------------
## 5 valores más bajos:
## [1] 84 90 92 95 95
## 5 valores más altos:
## [1] 172 174 176 179 208
## =============================
##
## =============================
## Variable: Presión diastólica (mm Hg)
## -----------------------------
## 5 valores más bajos:
## [1] 45 51 53 54 55
## 5 valores más altos:
## [1] 108 109 110 115 125
## =============================
##
## =============================
## Variable: Glucosa en ayunas (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 3.91 4.15 4.24 4.26 4.27
## 5 valores más altos:
## [1] 17.29 18.22 18.56 21.15 30.00
## =============================
##
## =============================
## Variable: Colesterol total (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 2.20 2.75 3.04 3.05 3.23
## 5 valores más altos:
## [1] 8.02 8.05 8.19 8.72 29.10
## =============================
##
## =============================
## Variable: Triglicéridos (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 0.38 0.40 0.42 0.45 0.49
## 5 valores más altos:
## [1] 6.69 7.82 10.79 11.34 13.14
## =============================
##
## =============================
## Variable: Colesterol HDL (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 0.31 0.66 0.67 0.76 0.81
## 5 valores más altos:
## [1] 2.21 2.23 2.24 2.33 2.40
## =============================
##
## =============================
## Variable: Colesterol LDL (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 1.25 1.35 1.41 1.44 1.45
## 5 valores más altos:
## [1] 4.75 4.90 5.27 5.36 6.09
## =============================
##
## =============================
## Variable: Alanina aminotransferasa (U/L)
## -----------------------------
## 5 valores más bajos:
## [1] 5 6 6 7 7
## 5 valores más altos:
## [1] 104 107 181 302 703
## =============================
##
## =============================
## Variable: Aspartato aminotransferasa (U/L)
## -----------------------------
## 5 valores más bajos:
## [1] 0.85 11.00 11.00 11.00 12.00
## 5 valores más altos:
## [1] 81 90 168 275 292
## =============================
##
## =============================
## Variable: Urea (mM)
## -----------------------------
## 5 valores más bajos:
## [1] 2.43 2.50 2.61 2.65 2.66
## 5 valores más altos:
## [1] 8.72 8.83 8.98 9.38 397.00
## =============================
##
## =============================
## Variable: Creatinina (µM)
## -----------------------------
## 5 valores más bajos:
## [1] 34 34 37 38 39
## 5 valores más altos:
## [1] 102 108 114 125 855
## =============================
##
## =============================
## Variable: Ácido úrico (µM)
## -----------------------------
## 5 valores más bajos:
## [1] 5.07 6.13 45.70 133.00 152.00
## 5 valores más altos:
## [1] 618 636 640 658 677
## =============================
##
## =============================
## Variable: Albúmina (g/L)
## -----------------------------
## 5 valores más bajos:
## [1] 18.4 38.0 38.2 39.5 39.7
## 5 valores más altos:
## [1] 51.7 52.9 68.8 4401.0 4701.0
## =============================
##
## =============================
## Variable: Fosfatasa alcalina (U/L)
## -----------------------------
## 5 valores más bajos:
## [1] 2.05 38.00 40.00 40.00 41.00
## 5 valores más altos:
## [1] 135 139 152 164 186
## =============================
##
## =============================
## Variable: Bilirrubina total (µM)
## -----------------------------
## 5 valores más bajos:
## [1] 5.6 6.8 7.0 7.0 7.2
## 5 valores más altos:
## [1] 34.3 34.7 38.8 47.0 52.0
## =============================
##
## =============================
## Variable: Bilirrubina directa (µM)
## -----------------------------
## 5 valores más bajos:
## [1] 1.1 1.4 1.5 1.6 1.8
## 5 valores más altos:
## [1] 8.3 9.0 9.6 11.9 14.5
## =============================
##
## =============================
## Variable: Ácidos biliares totales (µM)
## -----------------------------
## 5 valores más bajos:
## [1] 0.1 0.4 0.6 0.6 0.6
## 5 valores más altos:
## [1] 9.1 10.8 12.0 12.1 16.6
## =============================
##
## =============================
## Variable: Colinesterasa (U/L)
## -----------------------------
## 5 valores más bajos:
## [1] 144 178 187 209 219
## 5 valores más altos:
## [1] 605 624 629 650 870
## =============================
##
## =============================
## Variable: Leucocitos (10^9/L)
## -----------------------------
## 5 valores más bajos:
## [1] 2.70 2.93 2.98 3.15 3.29
## 5 valores más altos:
## [1] 10.68 11.18 11.23 11.52 628.00
## =============================
##
## =============================
## Variable: Υ-GT (U/L)
## -----------------------------
## 5 valores más bajos:
## [1] 8 8 8 9 10
## 5 valores más altos:
## [1] 140 143 195 261 271
## =============================
##
## =============================
## Variable: Neutrófilos (%)
## -----------------------------
## 5 valores más bajos:
## [1] 33.3 34.9 35.5 37.6 40.2
## 5 valores más altos:
## [1] 73.0 73.4 74.1 74.7 75.0
## =============================
##
## =============================
## Variable: Linfocitos (%)
## -----------------------------
## 5 valores más bajos:
## [1] 16.0 16.1 16.3 16.8 18.6
## 5 valores más altos:
## [1] 54.4 54.6 57.9 60.0 3401.0
## =============================
##
## =============================
## Variable: Eosinófilos (%)
## -----------------------------
## 5 valores más bajos:
## [1] 0.06 0.06 0.07 0.11 0.16
## 5 valores más altos:
## [1] 6.9 7.0 9.4 10.5 11.4
## =============================
##
## =============================
## Variable: Basófilos (%)
## -----------------------------
## 5 valores más bajos:
## [1] 0.00 0.00 0.00 0.01 0.02
## 5 valores más altos:
## [1] 1.5 1.7 1.8 1.8 2.1
## =============================
##
## =============================
## Variable: Hemoglobina A1c (%)
## -----------------------------
## 5 valores más bajos:
## [1] 4.9 5.0 5.0 5.0 5.0
## 5 valores más altos:
## [1] 12.5 13.5 13.6 14.3 14.8
## =============================# Variables con datos anormales
vars_continuas3 <- c( "Colesterol total (mM)",
"Alanina aminotransferasa (U/L)", "Urea (mM)", "Creatinina (µM)",
"Albúmina (g/L)", "Leucocitos (10^9/L)", "Linfocitos (%)")
# Límites usando media ± 3SD
limites <- lapply(vars_continuas3, function(var) {
# Convertir a numérico
x <- suppressWarnings(
as.numeric(baseline[[var]])
)
# Calcular media y SD
media <- mean(x, na.rm = TRUE)
sdv <- sd(x, na.rm = TRUE)
# Límites
c(
inf = media - 3 * sdv,
sup = media + 3 * sdv
)
})
# Asignar nombres
names(limites) <- vars_continuas3
# Encontrar filas con outliers
outlier_rows <- unique(unlist(
lapply(vars_continuas3, function(var) {
# Convertir a numérico
x <- suppressWarnings(
as.numeric(baseline[[var]])
)
# Buscar índices fuera de límites
which(
x < limites[[var]]["inf"] |
x > limites[[var]]["sup"]
)
})
))
# Extraer filas con outliers
filas_outliers <- baseline[outlier_rows, ]
# Seleccionar columnas numéricas
numeric_cols <- names(baseline)[
sapply(baseline, is.numeric)
]
# Calcular promedios
promedios <- sapply(
baseline[numeric_cols],
function(x) mean(x, na.rm = TRUE)
)
# Comparar outliers vs promedio
comparaciones <- lapply(
1:nrow(filas_outliers),
function(i) {
fila <- filas_outliers[i, numeric_cols]
data.frame(
Fila = outlier_rows[i],
Variable = numeric_cols,
Valor = as.numeric(fila),
Promedio = promedios[numeric_cols],
Diferencia = as.numeric(fila) - promedios[numeric_cols],
row.names = NULL
)
}
)
# Unir resultados
comparaciones_df <- do.call(rbind, comparaciones)
# Mostrar tabla final
print(comparaciones_df)## Fila Variable Valor Promedio Diferencia
## 1 138 Grupo 2.00000 1.6666667 3.333333e-01
## 2 138 Edad 29.00000 48.1033333 -1.910333e+01
## 3 138 Altura 160.50000 168.9810000 -8.481000e+00
## 4 138 Peso 64.90000 72.0360000 -7.136000e+00
## 5 138 Índice de masa corporal (kg/m²) 25.19385 25.1264947 6.736020e-02
## 6 138 Circunferencia de cintura (cm) 77.00000 84.4100000 -7.410000e+00
## 7 138 Presión sistólica (mm Hg) 125.00000 126.9833333 -1.983333e+00
## 8 138 Presión diastólica (mm Hg) 77.00000 78.7066667 -1.706667e+00
## 9 138 Hemoglobina A1c (%) 5.30000 6.4475000 -1.147500e+00
## 10 138 Glucosa en ayunas (mM) 5.42000 6.6941667 -1.274167e+00
## 11 138 Alanina aminotransferasa (U/L) 40.00000 29.8800000 1.012000e+01
## 12 138 Aspartato aminotransferasa (U/L) 24.00000 24.9828333 -9.828333e-01
## 13 138 Urea (mM) 5.54000 6.4457000 -9.057000e-01
## 14 138 Creatinina (µM) 55.00000 67.9600000 -1.296000e+01
## 15 138 Ácido úrico (µM) 334.00000 343.1596667 -9.159667e+00
## 16 138 Albúmina (g/L) 45.60000 75.9840000 -3.038400e+01
## 17 138 Colesterol total (mM) 29.10000 5.2225000 2.387750e+01
## 18 138 Triglicéridos (mM) 1.28000 1.7142333 -4.342333e-01
## 19 138 Colesterol HDL (mM) 1.87000 1.4242667 4.457333e-01
## 20 138 Colesterol LDL (mM) 2.35000 2.7575333 -4.075333e-01
## 21 138 Fosfatasa alcalina (U/L) 69.00000 75.6668333 -6.666833e+00
## 22 138 Υ-GT (U/L) 33.00000 34.9866667 -1.986667e+00
## 23 138 Bilirrubina total (µM) 12.80000 14.6566667 -1.856667e+00
## 24 138 Bilirrubina directa (µM) 3.80000 3.9183333 -1.183333e-01
## 25 138 Ácidos biliares totales (µM) 2.90000 2.8940000 6.000000e-03
## 26 138 Colinesterasa (U/L) 308.00000 391.9466667 -8.394667e+01
## 27 138 Leucocitos (10^9/L) 6.23000 8.0054000 -1.775400e+00
## 28 138 Neutrófilos (%) 54.50000 56.6200000 -2.120000e+00
## 29 138 Linfocitos (%) 37.90000 45.4336667 -7.533667e+00
## 30 138 Eosinófilos (%) 0.30000 2.1063667 -1.806367e+00
## 31 138 Basófilos (%) 0.20000 0.4947667 -2.947667e-01
## 32 4 Grupo 1.00000 1.6666667 -6.666667e-01
## 33 4 Edad 34.00000 48.1033333 -1.410333e+01
## 34 4 Altura 178.00000 168.9810000 9.019000e+00
## 35 4 Peso 68.00000 72.0360000 -4.036000e+00
## 36 4 Índice de masa corporal (kg/m²) 21.46000 25.1264947 -3.666495e+00
## 37 4 Circunferencia de cintura (cm) 96.00000 84.4100000 1.159000e+01
## 38 4 Presión sistólica (mm Hg) 126.00000 126.9833333 -9.833333e-01
## 39 4 Presión diastólica (mm Hg) 94.00000 78.7066667 1.529333e+01
## 40 4 Hemoglobina A1c (%) 11.50000 6.4475000 5.052500e+00
## 41 4 Glucosa en ayunas (mM) 12.35000 6.6941667 5.655833e+00
## 42 4 Alanina aminotransferasa (U/L) 703.00000 29.8800000 6.731200e+02
## 43 4 Aspartato aminotransferasa (U/L) 292.00000 24.9828333 2.670172e+02
## 44 4 Urea (mM) 3.58000 6.4457000 -2.865700e+00
## 45 4 Creatinina (µM) 52.00000 67.9600000 -1.596000e+01
## 46 4 Ácido úrico (µM) 337.00000 343.1596667 -6.159667e+00
## 47 4 Albúmina (g/L) 44.60000 75.9840000 -3.138400e+01
## 48 4 Colesterol total (mM) 4.45000 5.2225000 -7.725000e-01
## 49 4 Triglicéridos (mM) 1.39000 1.7142333 -3.242333e-01
## 50 4 Colesterol HDL (mM) 0.92000 1.4242667 -5.042667e-01
## 51 4 Colesterol LDL (mM) 2.63000 2.7575333 -1.275333e-01
## 52 4 Fosfatasa alcalina (U/L) 89.00000 75.6668333 1.333317e+01
## 53 4 Υ-GT (U/L) 195.00000 34.9866667 1.600133e+02
## 54 4 Bilirrubina total (µM) 16.70000 14.6566667 2.043333e+00
## 55 4 Bilirrubina directa (µM) 5.50000 3.9183333 1.581667e+00
## 56 4 Ácidos biliares totales (µM) 3.70000 2.8940000 8.060000e-01
## 57 4 Colinesterasa (U/L) 450.00000 391.9466667 5.805333e+01
## 58 4 Leucocitos (10^9/L) 6.36000 8.0054000 -1.645400e+00
## 59 4 Neutrófilos (%) 37.60000 56.6200000 -1.902000e+01
## 60 4 Linfocitos (%) 54.60000 45.4336667 9.166333e+00
## 61 4 Eosinófilos (%) 1.30000 2.1063667 -8.063667e-01
## 62 4 Basófilos (%) 0.50000 0.4947667 5.233333e-03
## 63 23 Grupo 1.00000 1.6666667 -6.666667e-01
## 64 23 Edad 35.00000 48.1033333 -1.310333e+01
## 65 23 Altura 180.00000 168.9810000 1.101900e+01
## 66 23 Peso 113.40000 72.0360000 4.136400e+01
## 67 23 Índice de masa corporal (kg/m²) 35.00000 25.1264947 9.873505e+00
## 68 23 Circunferencia de cintura (cm) 117.00000 84.4100000 3.259000e+01
## 69 23 Presión sistólica (mm Hg) 152.00000 126.9833333 2.501667e+01
## 70 23 Presión diastólica (mm Hg) 86.00000 78.7066667 7.293333e+00
## 71 23 Hemoglobina A1c (%) 8.90000 6.4475000 2.452500e+00
## 72 23 Glucosa en ayunas (mM) 10.39000 6.6941667 3.695833e+00
## 73 23 Alanina aminotransferasa (U/L) 302.00000 29.8800000 2.721200e+02
## 74 23 Aspartato aminotransferasa (U/L) 275.00000 24.9828333 2.500172e+02
## 75 23 Urea (mM) 3.60000 6.4457000 -2.845700e+00
## 76 23 Creatinina (µM) 55.00000 67.9600000 -1.296000e+01
## 77 23 Ácido úrico (µM) 402.00000 343.1596667 5.884033e+01
## 78 23 Albúmina (g/L) 42.90000 75.9840000 -3.308400e+01
## 79 23 Colesterol total (mM) 8.72000 5.2225000 3.497500e+00
## 80 23 Triglicéridos (mM) 4.10000 1.7142333 2.385767e+00
## 81 23 Colesterol HDL (mM) 1.36000 1.4242667 -6.426667e-02
## 82 23 Colesterol LDL (mM) 5.36000 2.7575333 2.602467e+00
## 83 23 Fosfatasa alcalina (U/L) 110.00000 75.6668333 3.433317e+01
## 84 23 Υ-GT (U/L) 261.00000 34.9866667 2.260133e+02
## 85 23 Bilirrubina total (µM) 19.40000 14.6566667 4.743333e+00
## 86 23 Bilirrubina directa (µM) 4.20000 3.9183333 2.816667e-01
## 87 23 Ácidos biliares totales (µM) 3.90000 2.8940000 1.006000e+00
## 88 23 Colinesterasa (U/L) 530.00000 391.9466667 1.380533e+02
## 89 23 Leucocitos (10^9/L) 5.83000 8.0054000 -2.175400e+00
## 90 23 Neutrófilos (%) 51.50000 56.6200000 -5.120000e+00
## 91 23 Linfocitos (%) 34.10000 45.4336667 -1.133367e+01
## 92 23 Eosinófilos (%) 5.50000 2.1063667 3.393633e+00
## 93 23 Basófilos (%) 1.20000 0.4947667 7.052333e-01
## 94 43 Grupo 1.00000 1.6666667 -6.666667e-01
## 95 43 Edad 36.00000 48.1033333 -1.210333e+01
## 96 43 Altura 165.00000 168.9810000 -3.981000e+00
## 97 43 Peso 70.00000 72.0360000 -2.036000e+00
## 98 43 Índice de masa corporal (kg/m²) 25.71166 25.1264947 5.851674e-01
## 99 43 Circunferencia de cintura (cm) 83.00000 84.4100000 -1.410000e+00
## 100 43 Presión sistólica (mm Hg) 137.00000 126.9833333 1.001667e+01
## 101 43 Presión diastólica (mm Hg) 80.00000 78.7066667 1.293333e+00
## 102 43 Hemoglobina A1c (%) 6.51000 6.4475000 6.250000e-02
## 103 43 Glucosa en ayunas (mM) 8.52000 6.6941667 1.825833e+00
## 104 43 Alanina aminotransferasa (U/L) 181.00000 29.8800000 1.511200e+02
## 105 43 Aspartato aminotransferasa (U/L) 168.00000 24.9828333 1.430172e+02
## 106 43 Urea (mM) 2.82000 6.4457000 -3.625700e+00
## 107 43 Creatinina (µM) 51.00000 67.9600000 -1.696000e+01
## 108 43 Ácido úrico (µM) 372.00000 343.1596667 2.884033e+01
## 109 43 Albúmina (g/L) 50.30000 75.9840000 -2.568400e+01
## 110 43 Colesterol total (mM) 6.19000 5.2225000 9.675000e-01
## 111 43 Triglicéridos (mM) 6.51000 1.7142333 4.795767e+00
## 112 43 Colesterol HDL (mM) 0.95000 1.4242667 -4.742667e-01
## 113 43 Colesterol LDL (mM) 3.65000 2.7575333 8.924667e-01
## 114 43 Fosfatasa alcalina (U/L) 72.00000 75.6668333 -3.666833e+00
## 115 43 Υ-GT (U/L) 120.00000 34.9866667 8.501333e+01
## 116 43 Bilirrubina total (µM) 18.00000 14.6566667 3.343333e+00
## 117 43 Bilirrubina directa (µM) 3.70000 3.9183333 -2.183333e-01
## 118 43 Ácidos biliares totales (µM) 12.10000 2.8940000 9.206000e+00
## 119 43 Colinesterasa (U/L) 425.00000 391.9466667 3.305333e+01
## 120 43 Leucocitos (10^9/L) 10.50000 8.0054000 2.494600e+00
## 121 43 Neutrófilos (%) 53.00000 56.6200000 -3.620000e+00
## 122 43 Linfocitos (%) 37.30000 45.4336667 -8.133667e+00
## 123 43 Eosinófilos (%) 3.20000 2.1063667 1.093633e+00
## 124 43 Basófilos (%) 0.90000 0.4947667 4.052333e-01
## 125 153 Grupo 2.00000 1.6666667 3.333333e-01
## 126 153 Edad 54.00000 48.1033333 5.896667e+00
## 127 153 Altura 157.00000 168.9810000 -1.198100e+01
## 128 153 Peso 41.10000 72.0360000 -3.093600e+01
## 129 153 Índice de masa corporal (kg/m²) 16.67410 25.1264947 -8.452390e+00
## 130 153 Circunferencia de cintura (cm) 59.00000 84.4100000 -2.541000e+01
## 131 153 Presión sistólica (mm Hg) 108.00000 126.9833333 -1.898333e+01
## 132 153 Presión diastólica (mm Hg) 77.00000 78.7066667 -1.706667e+00
## 133 153 Hemoglobina A1c (%) 5.80000 6.4475000 -6.475000e-01
## 134 153 Glucosa en ayunas (mM) 4.49000 6.6941667 -2.204167e+00
## 135 153 Alanina aminotransferasa (U/L) 13.00000 29.8800000 -1.688000e+01
## 136 153 Aspartato aminotransferasa (U/L) 23.00000 24.9828333 -1.982833e+00
## 137 153 Urea (mM) 397.00000 6.4457000 3.905543e+02
## 138 153 Creatinina (µM) 64.00000 67.9600000 -3.960000e+00
## 139 153 Ácido úrico (µM) 234.00000 343.1596667 -1.091597e+02
## 140 153 Albúmina (g/L) 48.30000 75.9840000 -2.768400e+01
## 141 153 Colesterol total (mM) 6.15000 5.2225000 9.275000e-01
## 142 153 Triglicéridos (mM) 1.12000 1.7142333 -5.942333e-01
## 143 153 Colesterol HDL (mM) 2.00000 1.4242667 5.757333e-01
## 144 153 Colesterol LDL (mM) 3.12000 2.7575333 3.624667e-01
## 145 153 Fosfatasa alcalina (U/L) 130.00000 75.6668333 5.433317e+01
## 146 153 Υ-GT (U/L) 15.00000 34.9866667 -1.998667e+01
## 147 153 Bilirrubina total (µM) 12.80000 14.6566667 -1.856667e+00
## 148 153 Bilirrubina directa (µM) 2.70000 3.9183333 -1.218333e+00
## 149 153 Ácidos biliares totales (µM) 2.10000 2.8940000 -7.940000e-01
## 150 153 Colinesterasa (U/L) 300.00000 391.9466667 -9.194667e+01
## 151 153 Leucocitos (10^9/L) 5.47000 8.0054000 -2.535400e+00
## 152 153 Neutrófilos (%) 60.80000 56.6200000 4.180000e+00
## 153 153 Linfocitos (%) 34.00000 45.4336667 -1.143367e+01
## 154 153 Eosinófilos (%) 0.70000 2.1063667 -1.406367e+00
## 155 153 Basófilos (%) 0.50000 0.4947667 5.233333e-03
## 156 187 Grupo 2.00000 1.6666667 3.333333e-01
## 157 187 Edad 42.00000 48.1033333 -6.103333e+00
## 158 187 Altura 185.00000 168.9810000 1.601900e+01
## 159 187 Peso 102.00000 72.0360000 2.996400e+01
## 160 187 Índice de masa corporal (kg/m²) 29.80278 25.1264947 4.676281e+00
## 161 187 Circunferencia de cintura (cm) 99.00000 84.4100000 1.459000e+01
## 162 187 Presión sistólica (mm Hg) 126.00000 126.9833333 -9.833333e-01
## 163 187 Presión diastólica (mm Hg) 79.00000 78.7066667 2.933333e-01
## 164 187 Hemoglobina A1c (%) 5.60000 6.4475000 -8.475000e-01
## 165 187 Glucosa en ayunas (mM) 30.00000 6.6941667 2.330583e+01
## 166 187 Alanina aminotransferasa (U/L) 25.00000 29.8800000 -4.880000e+00
## 167 187 Aspartato aminotransferasa (U/L) 0.85000 24.9828333 -2.413283e+01
## 168 187 Urea (mM) 5.50000 6.4457000 -9.457000e-01
## 169 187 Creatinina (µM) 855.00000 67.9600000 7.870400e+02
## 170 187 Ácido úrico (µM) 401.00000 343.1596667 5.784033e+01
## 171 187 Albúmina (g/L) 47.00000 75.9840000 -2.898400e+01
## 172 187 Colesterol total (mM) 5.11000 5.2225000 -1.125000e-01
## 173 187 Triglicéridos (mM) 3.23000 1.7142333 1.515767e+00
## 174 187 Colesterol HDL (mM) 1.17000 1.4242667 -2.542667e-01
## 175 187 Colesterol LDL (mM) 2.76000 2.7575333 2.466667e-03
## 176 187 Fosfatasa alcalina (U/L) 67.00000 75.6668333 -8.666833e+00
## 177 187 Υ-GT (U/L) 18.00000 34.9866667 -1.698667e+01
## 178 187 Bilirrubina total (µM) 12.90000 14.6566667 -1.756667e+00
## 179 187 Bilirrubina directa (µM) 3.40000 3.9183333 -5.183333e-01
## 180 187 Ácidos biliares totales (µM) 2.10000 2.8940000 -7.940000e-01
## 181 187 Colinesterasa (U/L) 468.00000 391.9466667 7.605333e+01
## 182 187 Leucocitos (10^9/L) 6.23000 8.0054000 -1.775400e+00
## 183 187 Neutrófilos (%) 63.50000 56.6200000 6.880000e+00
## 184 187 Linfocitos (%) 27.80000 45.4336667 -1.763367e+01
## 185 187 Eosinófilos (%) 1.60000 2.1063667 -5.063667e-01
## 186 187 Basófilos (%) 0.20000 0.4947667 -2.947667e-01
## 187 230 Grupo 2.00000 1.6666667 3.333333e-01
## 188 230 Edad 47.00000 48.1033333 -1.103333e+00
## 189 230 Altura 172.00000 168.9810000 3.019000e+00
## 190 230 Peso 58.80000 72.0360000 -1.323600e+01
## 191 230 Índice de masa corporal (kg/m²) 19.87561 25.1264947 -5.250886e+00
## 192 230 Circunferencia de cintura (cm) 75.00000 84.4100000 -9.410000e+00
## 193 230 Presión sistólica (mm Hg) 131.00000 126.9833333 4.016667e+00
## 194 230 Presión diastólica (mm Hg) 74.00000 78.7066667 -4.706667e+00
## 195 230 Hemoglobina A1c (%) 5.40000 6.4475000 -1.047500e+00
## 196 230 Glucosa en ayunas (mM) 5.20000 6.6941667 -1.494167e+00
## 197 230 Alanina aminotransferasa (U/L) 11.00000 29.8800000 -1.888000e+01
## 198 230 Aspartato aminotransferasa (U/L) 11.00000 24.9828333 -1.398283e+01
## 199 230 Urea (mM) 3.21000 6.4457000 -3.235700e+00
## 200 230 Creatinina (µM) 43.00000 67.9600000 -2.496000e+01
## 201 230 Ácido úrico (µM) 203.00000 343.1596667 -1.401597e+02
## 202 230 Albúmina (g/L) 4401.00000 75.9840000 4.325016e+03
## 203 230 Colesterol total (mM) 4.80000 5.2225000 -4.225000e-01
## 204 230 Triglicéridos (mM) 0.96000 1.7142333 -7.542333e-01
## 205 230 Colesterol HDL (mM) 1.78000 1.4242667 3.557333e-01
## 206 230 Colesterol LDL (mM) 2.26000 2.7575333 -4.975333e-01
## 207 230 Fosfatasa alcalina (U/L) 44.00000 75.6668333 -3.166683e+01
## 208 230 Υ-GT (U/L) 17.00000 34.9866667 -1.798667e+01
## 209 230 Bilirrubina total (µM) 8.20000 14.6566667 -6.456667e+00
## 210 230 Bilirrubina directa (µM) 2.00000 3.9183333 -1.918333e+00
## 211 230 Ácidos biliares totales (µM) 4.80000 2.8940000 1.906000e+00
## 212 230 Colinesterasa (U/L) 284.00000 391.9466667 -1.079467e+02
## 213 230 Leucocitos (10^9/L) 4.55000 8.0054000 -3.455400e+00
## 214 230 Neutrófilos (%) 53.10000 56.6200000 -3.520000e+00
## 215 230 Linfocitos (%) 37.80000 45.4336667 -7.633667e+00
## 216 230 Eosinófilos (%) 0.40000 2.1063667 -1.706367e+00
## 217 230 Basófilos (%) 0.40000 0.4947667 -9.476667e-02
## 218 298 Grupo 2.00000 1.6666667 3.333333e-01
## 219 298 Edad 44.00000 48.1033333 -4.103333e+00
## 220 298 Altura 177.00000 168.9810000 8.019000e+00
## 221 298 Peso 83.60000 72.0360000 1.156400e+01
## 222 298 Índice de masa corporal (kg/m²) 26.68454 25.1264947 1.558047e+00
## 223 298 Circunferencia de cintura (cm) 90.00000 84.4100000 5.590000e+00
## 224 298 Presión sistólica (mm Hg) 130.00000 126.9833333 3.016667e+00
## 225 298 Presión diastólica (mm Hg) 88.00000 78.7066667 9.293333e+00
## 226 298 Hemoglobina A1c (%) 5.70000 6.4475000 -7.475000e-01
## 227 298 Glucosa en ayunas (mM) 5.03000 6.6941667 -1.664167e+00
## 228 298 Alanina aminotransferasa (U/L) 43.00000 29.8800000 1.312000e+01
## 229 298 Aspartato aminotransferasa (U/L) 29.00000 24.9828333 4.017167e+00
## 230 298 Urea (mM) 5.33000 6.4457000 -1.115700e+00
## 231 298 Creatinina (µM) 77.00000 67.9600000 9.040000e+00
## 232 298 Ácido úrico (µM) 392.00000 343.1596667 4.884033e+01
## 233 298 Albúmina (g/L) 4701.00000 75.9840000 4.625016e+03
## 234 298 Colesterol total (mM) 7.01000 5.2225000 1.787500e+00
## 235 298 Triglicéridos (mM) 1.75000 1.7142333 3.576667e-02
## 236 298 Colesterol HDL (mM) 1.53000 1.4242667 1.057333e-01
## 237 298 Colesterol LDL (mM) 4.30000 2.7575333 1.542467e+00
## 238 298 Fosfatasa alcalina (U/L) 54.00000 75.6668333 -2.166683e+01
## 239 298 Υ-GT (U/L) 19.00000 34.9866667 -1.598667e+01
## 240 298 Bilirrubina total (µM) 12.50000 14.6566667 -2.156667e+00
## 241 298 Bilirrubina directa (µM) 2.80000 3.9183333 -1.118333e+00
## 242 298 Ácidos biliares totales (µM) 2.00000 2.8940000 -8.940000e-01
## 243 298 Colinesterasa (U/L) 449.00000 391.9466667 5.705333e+01
## 244 298 Leucocitos (10^9/L) 4.69000 8.0054000 -3.315400e+00
## 245 298 Neutrófilos (%) 54.70000 56.6200000 -1.920000e+00
## 246 298 Linfocitos (%) 39.00000 45.4336667 -6.433667e+00
## 247 298 Eosinófilos (%) 0.60000 2.1063667 -1.506367e+00
## 248 298 Basófilos (%) 0.60000 0.4947667 1.052333e-01
## 249 225 Grupo 2.00000 1.6666667 3.333333e-01
## 250 225 Edad 63.00000 48.1033333 1.489667e+01
## 251 225 Altura 168.50000 168.9810000 -4.810000e-01
## 252 225 Peso 73.80000 72.0360000 1.764000e+00
## 253 225 Índice de masa corporal (kg/m²) 25.99301 25.1264947 8.665140e-01
## 254 225 Circunferencia de cintura (cm) 90.00000 84.4100000 5.590000e+00
## 255 225 Presión sistólica (mm Hg) 132.00000 126.9833333 5.016667e+00
## 256 225 Presión diastólica (mm Hg) 85.00000 78.7066667 6.293333e+00
## 257 225 Hemoglobina A1c (%) 5.30000 6.4475000 -1.147500e+00
## 258 225 Glucosa en ayunas (mM) 5.08000 6.6941667 -1.614167e+00
## 259 225 Alanina aminotransferasa (U/L) 17.00000 29.8800000 -1.288000e+01
## 260 225 Aspartato aminotransferasa (U/L) 16.00000 24.9828333 -8.982833e+00
## 261 225 Urea (mM) 3.50000 6.4457000 -2.945700e+00
## 262 225 Creatinina (µM) 76.00000 67.9600000 8.040000e+00
## 263 225 Ácido úrico (µM) 372.00000 343.1596667 2.884033e+01
## 264 225 Albúmina (g/L) 42.50000 75.9840000 -3.348400e+01
## 265 225 Colesterol total (mM) 3.83000 5.2225000 -1.392500e+00
## 266 225 Triglicéridos (mM) 1.05000 1.7142333 -6.642333e-01
## 267 225 Colesterol HDL (mM) 1.07000 1.4242667 -3.542667e-01
## 268 225 Colesterol LDL (mM) 2.04000 2.7575333 -7.175333e-01
## 269 225 Fosfatasa alcalina (U/L) 84.00000 75.6668333 8.333167e+00
## 270 225 Υ-GT (U/L) 28.00000 34.9866667 -6.986667e+00
## 271 225 Bilirrubina total (µM) 34.10000 14.6566667 1.944333e+01
## 272 225 Bilirrubina directa (µM) 7.80000 3.9183333 3.881667e+00
## 273 225 Ácidos biliares totales (µM) 1.70000 2.8940000 -1.194000e+00
## 274 225 Colinesterasa (U/L) 288.00000 391.9466667 -1.039467e+02
## 275 225 Leucocitos (10^9/L) 628.00000 8.0054000 6.199946e+02
## 276 225 Neutrófilos (%) 60.00000 56.6200000 3.380000e+00
## 277 225 Linfocitos (%) 30.50000 45.4336667 -1.493367e+01
## 278 225 Eosinófilos (%) 1.10000 2.1063667 -1.006367e+00
## 279 225 Basófilos (%) 0.50000 0.4947667 5.233333e-03
## 280 276 Grupo 2.00000 1.6666667 3.333333e-01
## 281 276 Edad 43.00000 48.1033333 -5.103333e+00
## 282 276 Altura 174.50000 168.9810000 5.519000e+00
## 283 276 Peso 79.40000 72.0360000 7.364000e+00
## 284 276 Índice de masa corporal (kg/m²) 26.07532 25.1264947 9.488249e-01
## 285 276 Circunferencia de cintura (cm) 90.00000 84.4100000 5.590000e+00
## 286 276 Presión sistólica (mm Hg) 124.00000 126.9833333 -2.983333e+00
## 287 276 Presión diastólica (mm Hg) 77.00000 78.7066667 -1.706667e+00
## 288 276 Hemoglobina A1c (%) 5.30000 6.4475000 -1.147500e+00
## 289 276 Glucosa en ayunas (mM) 4.94000 6.6941667 -1.754167e+00
## 290 276 Alanina aminotransferasa (U/L) 31.00000 29.8800000 1.120000e+00
## 291 276 Aspartato aminotransferasa (U/L) 25.00000 24.9828333 1.716667e-02
## 292 276 Urea (mM) 6.68000 6.4457000 2.343000e-01
## 293 276 Creatinina (µM) 85.00000 67.9600000 1.704000e+01
## 294 276 Ácido úrico (µM) 402.00000 343.1596667 5.884033e+01
## 295 276 Albúmina (g/L) 48.00000 75.9840000 -2.798400e+01
## 296 276 Colesterol total (mM) 5.87000 5.2225000 6.475000e-01
## 297 276 Triglicéridos (mM) 1.57000 1.7142333 -1.442333e-01
## 298 276 Colesterol HDL (mM) 1.26000 1.4242667 -1.642667e-01
## 299 276 Colesterol LDL (mM) 3.56000 2.7575333 8.024667e-01
## 300 276 Fosfatasa alcalina (U/L) 85.00000 75.6668333 9.333167e+00
## 301 276 Υ-GT (U/L) 37.00000 34.9866667 2.013333e+00
## 302 276 Bilirrubina total (µM) 16.90000 14.6566667 2.243333e+00
## 303 276 Bilirrubina directa (µM) 4.50000 3.9183333 5.816667e-01
## 304 276 Ácidos biliares totales (µM) 2.80000 2.8940000 -9.400000e-02
## 305 276 Colinesterasa (U/L) 435.00000 391.9466667 4.305333e+01
## 306 276 Leucocitos (10^9/L) 5.48000 8.0054000 -2.525400e+00
## 307 276 Neutrófilos (%) 52.40000 56.6200000 -4.220000e+00
## 308 276 Linfocitos (%) 3401.00000 45.4336667 3.355566e+03
## 309 276 Eosinófilos (%) 6.20000 2.1063667 4.093633e+00
## 310 276 Basófilos (%) 0.50000 0.4947667 5.233333e-03Imputación Baseline
#Eliminar filas con outliers relacionados con T2DM
Baseline_limpia <- Baseline_original[
-c(4, 23, 43, 153, 187, 230, 298),
]
# Reemplazar con NA los outliers a imputar
Baseline_limpia$`WBC (10^9/L)`[
Baseline_limpia$`WBC (10^9/L)` == 628.00
] <- NA
Baseline_limpia$`LYMPH (%)`[
Baseline_limpia$`LYMPH (%)` == 3401.00
] <- NA
#Configurar imputacion
metodos <- make.method(Baseline_limpia)
# Para sólo imputar Na´s
metodos[] <- ""
metodos["WBC (10^9/L)"] <- "pmm"
metodos["LYMPH (%)"] <- "pmm"
#Mice
imp <- mice(
Baseline_limpia,
method = metodos,
m = 5,
maxit = 10,
seed = 123
)##
## iter imp variable
## 1 1 WBC (10^9/L) LYMPH (%)
## 1 2 WBC (10^9/L) LYMPH (%)
## 1 3 WBC (10^9/L) LYMPH (%)
## 1 4 WBC (10^9/L) LYMPH (%)
## 1 5 WBC (10^9/L) LYMPH (%)
## 2 1 WBC (10^9/L) LYMPH (%)
## 2 2 WBC (10^9/L) LYMPH (%)
## 2 3 WBC (10^9/L) LYMPH (%)
## 2 4 WBC (10^9/L) LYMPH (%)
## 2 5 WBC (10^9/L) LYMPH (%)
## 3 1 WBC (10^9/L) LYMPH (%)
## 3 2 WBC (10^9/L) LYMPH (%)
## 3 3 WBC (10^9/L) LYMPH (%)
## 3 4 WBC (10^9/L) LYMPH (%)
## 3 5 WBC (10^9/L) LYMPH (%)
## 4 1 WBC (10^9/L) LYMPH (%)
## 4 2 WBC (10^9/L) LYMPH (%)
## 4 3 WBC (10^9/L) LYMPH (%)
## 4 4 WBC (10^9/L) LYMPH (%)
## 4 5 WBC (10^9/L) LYMPH (%)
## 5 1 WBC (10^9/L) LYMPH (%)
## 5 2 WBC (10^9/L) LYMPH (%)
## 5 3 WBC (10^9/L) LYMPH (%)
## 5 4 WBC (10^9/L) LYMPH (%)
## 5 5 WBC (10^9/L) LYMPH (%)
## 6 1 WBC (10^9/L) LYMPH (%)
## 6 2 WBC (10^9/L) LYMPH (%)
## 6 3 WBC (10^9/L) LYMPH (%)
## 6 4 WBC (10^9/L) LYMPH (%)
## 6 5 WBC (10^9/L) LYMPH (%)
## 7 1 WBC (10^9/L) LYMPH (%)
## 7 2 WBC (10^9/L) LYMPH (%)
## 7 3 WBC (10^9/L) LYMPH (%)
## 7 4 WBC (10^9/L) LYMPH (%)
## 7 5 WBC (10^9/L) LYMPH (%)
## 8 1 WBC (10^9/L) LYMPH (%)
## 8 2 WBC (10^9/L) LYMPH (%)
## 8 3 WBC (10^9/L) LYMPH (%)
## 8 4 WBC (10^9/L) LYMPH (%)
## 8 5 WBC (10^9/L) LYMPH (%)
## 9 1 WBC (10^9/L) LYMPH (%)
## 9 2 WBC (10^9/L) LYMPH (%)
## 9 3 WBC (10^9/L) LYMPH (%)
## 9 4 WBC (10^9/L) LYMPH (%)
## 9 5 WBC (10^9/L) LYMPH (%)
## 10 1 WBC (10^9/L) LYMPH (%)
## 10 2 WBC (10^9/L) LYMPH (%)
## 10 3 WBC (10^9/L) LYMPH (%)
## 10 4 WBC (10^9/L) LYMPH (%)
## 10 5 WBC (10^9/L) LYMPH (%)## Warning: Number of logged events: 3#Usar el 3er valor
Baseline_final <- complete(imp, 3)
#Revisar los datos imputados
imp$imp$`WBC (10^9/L)`## [1] 0Metabolomics
Importar Metabolomics
Corrección de la base
#Eliminar la columna de HMDB ID
Metabolomics_original <- Metabolomics_original %>%
select(-`HMDB ID`)
#Guardar los nombres de los metabolitos
nombres_metabolitos <- Metabolomics_original[[1]]
nombres_metabolitos <- make.unique(nombres_metabolitos)
# Transponer
Metabolomics_t <- as.data.frame(
t(Metabolomics_original[-1])
)
#Nuevos nombres de columnas
colnames(Metabolomics_t) <- nombres_metabolitos
#Columna de ID´s
Metabolomics_t$ID <- rownames(Metabolomics_t)
rownames(Metabolomics_t) <- NULL
Metabolomics_t <- Metabolomics_t %>%
select(ID, everything())
#Eliminar filas extra
Metabolomics_t <- Metabolomics_t[-c(301:322), ]
#Eliminar filas con outliers de baseline
Metabolomics_t <- Metabolomics_t[-c(4, 23, 43, 153, 187, 230, 298), ]
sum(is.na(Metabolomics_t))## [1] 0Outliers Metabolomics
# Variables numéricas
vars_metabolitos <- names(Metabolomics_t)[
sapply(Metabolomics_t, is.numeric)
]
# Explorar extremos
for (var in vars_metabolitos) {
# Convertir a numérico
x <- suppressWarnings(
as.numeric(Metabolomics_t[[var]])
)
# Eliminar NA
x <- na.omit(x)
if(length(x) > 0){
cat("\n=============================\n")
cat("Metabolito:", var, "\n")
cat("-----------------------------\n")
# Valores mínimos
cat("5 valores más bajos:\n")
print(head(sort(x), 5))
# Valores máximos
cat("5 valores más altos:\n")
print(tail(sort(x), 5))
cat("=============================\n")
} else {
cat("\n", var,
"no tiene datos numéricos válidos.\n")
}
}##
## =============================
## Metabolito: Phenylethylamine
## -----------------------------
## 5 valores más bajos:
## [1] 0.001965008 0.002543631 0.002663303 0.002883755 0.003636136
## 5 valores más altos:
## [1] 0.8243222 1.7538262 2.2236586 2.5381163 6.5633189
## =============================
##
## =============================
## Metabolito: Octadecanamide
## -----------------------------
## 5 valores más bajos:
## [1] 0.009179822 0.018893993 0.023312722 0.023536983 0.055153305
## 5 valores más altos:
## [1] 11.78065 11.89336 12.16088 14.36820 19.81913
## =============================
##
## =============================
## Metabolito: Urocanic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.005994619 0.006871582 0.007101920 0.008161419 0.012207425
## 5 valores más altos:
## [1] 17.89947 20.01439 28.68277 51.79882 94.18954
## =============================
##
## =============================
## Metabolito: Imidazolepropionic acid
## -----------------------------
## 5 valores más bajos:
## [1] 7.53347 10.06435 10.28354 10.71206 10.75667
## 5 valores más altos:
## [1] 62.97161 65.75179 66.77942 67.89119 80.74106
## =============================
##
## =============================
## Metabolito: Indole-3-carboxaldehyde
## -----------------------------
## 5 valores más bajos:
## [1] 0.03479561 0.03874127 0.04825228 0.05283154 0.05510723
## 5 valores más altos:
## [1] 0.2387424 0.2392772 0.2443356 0.2452961 0.2738282
## =============================
##
## =============================
## Metabolito: 3-Hydroxyanthranilic acid
## -----------------------------
## 5 valores más bajos:
## [1] 1.406624 1.486531 1.685880 1.924599 1.926291
## 5 valores más altos:
## [1] 23.66510 24.05800 24.19400 24.95493 32.31656
## =============================
##
## =============================
## Metabolito: Dopamine
## -----------------------------
## 5 valores más bajos:
## [1] 5.312186 5.978965 6.416447 7.157345 7.558840
## 5 valores más altos:
## [1] 32.70128 36.97882 43.30772 44.01756 51.91532
## =============================
##
## =============================
## Metabolito: Oleamide
## -----------------------------
## 5 valores más bajos:
## [1] 38.22081 39.60079 40.05887 41.26241 43.15611
## 5 valores más altos:
## [1] 1588.287 1693.125 1699.049 1878.722 2036.573
## =============================
##
## =============================
## Metabolito: Oleoylethanolamide
## -----------------------------
## 5 valores más bajos:
## [1] 0.3534358 0.3874051 0.4387574 0.4667520 0.4678366
## 5 valores más altos:
## [1] 1.518631 1.548896 1.552036 1.693117 1.722261
## =============================
##
## =============================
## Metabolito: Palmitic amide
## -----------------------------
## 5 valores más bajos:
## [1] 0.009994766 0.012786493 0.034597260 0.040892020 0.132111897
## 5 valores más altos:
## [1] 19.82981 20.85237 21.70541 22.23706 28.01012
## =============================
##
## =============================
## Metabolito: Palmitoylethanolamide
## -----------------------------
## 5 valores más bajos:
## [1] 0.1849488 0.2032285 0.2803073 0.3124996 0.3639855
## 5 valores más altos:
## [1] 1.755457 1.864903 1.885870 1.989479 2.036948
## =============================
##
## =============================
## Metabolito: Stearoylethanolamide
## -----------------------------
## 5 valores más bajos:
## [1] 0.3086925 0.6871800 0.7550370 0.7625056 0.7947427
## 5 valores más altos:
## [1] 6.863226 7.123396 7.673891 7.765642 8.865747
## =============================
##
## =============================
## Metabolito: Bilirubin
## -----------------------------
## 5 valores más bajos:
## [1] 297.9844 504.6067 9691.2647 10091.7895 10345.6135
## 5 valores más altos:
## [1] 57467.02 60404.06 68859.89 69913.69 107755.68
## =============================
##
## =============================
## Metabolito: Biliverdin
## -----------------------------
## 5 valores más bajos:
## [1] 10.67585 12.26926 12.54873 12.69344 12.76741
## 5 valores más altos:
## [1] 102.7464 106.3522 109.0859 112.0442 119.6844
## =============================
##
## =============================
## Metabolito: Indole-3-acrylic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.06184433 0.08807901 0.09003237 0.09599161 0.09615925
## 5 valores más altos:
## [1] 5.286491 5.403995 5.630575 5.824924 9.951957
## =============================
##
## =============================
## Metabolito: Kynurenic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.7262206 0.7317823 0.7820277 0.7899870 0.7930472
## 5 valores más altos:
## [1] 3.272592 3.274872 3.562329 3.852096 4.051402
## =============================
##
## =============================
## Metabolito: Indole-3-propionic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.6281992 0.7319802 0.8438400 0.9531680 1.5302334
## 5 valores más altos:
## [1] 2533.516 2587.784 3282.392 3588.590 3668.049
## =============================
##
## =============================
## Metabolito: Indole-3-methyl acetate
## -----------------------------
## 5 valores más bajos:
## [1] 0.05258948 0.05538408 0.06741004 0.11374098 0.13754458
## 5 valores más altos:
## [1] 249.4905 268.7125 341.1780 341.2229 343.6903
## =============================
##
## =============================
## Metabolito: Dopa
## -----------------------------
## 5 valores más bajos:
## [1] 2.406700 3.058027 6.226166 9.045748 9.129165
## 5 valores más altos:
## [1] 265.3975 288.2804 294.8500 298.0085 415.5126
## =============================
##
## =============================
## Metabolito: Sphinganine
## -----------------------------
## 5 valores más bajos:
## [1] 0.1867854 0.2657892 0.3118506 0.3503416 0.3548671
## 5 valores más altos:
## [1] 2.117074 2.123937 2.149654 2.245940 4.185343
## =============================
##
## =============================
## Metabolito: Sphinganine-1-phosphate
## -----------------------------
## 5 valores más bajos:
## [1] 23.90091 25.16066 26.53437 28.22000 28.57148
## 5 valores más altos:
## [1] 107.2677 109.3094 111.9755 112.8826 120.2851
## =============================
##
## =============================
## Metabolito: Sphingosine
## -----------------------------
## 5 valores más bajos:
## [1] 1.228466 1.405898 1.600225 1.612955 1.640767
## 5 valores más altos:
## [1] 6.256723 6.566174 7.213050 10.492195 10.679386
## =============================
##
## =============================
## Metabolito: 3-Indolebutyric acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.004017135 0.016001901 0.038487078 0.052163359 0.082046464
## 5 valores más altos:
## [1] 1.311016 1.327243 1.346401 1.606243 1.797122
## =============================
##
## =============================
## Metabolito: Sphingosine-1-phosphate
## -----------------------------
## 5 valores más bajos:
## [1] 94.31471 97.47001 101.83094 107.42401 107.61468
## 5 valores más altos:
## [1] 220.7591 221.4799 222.6119 224.5703 225.8643
## =============================
##
## =============================
## Metabolito: 5-Methoxyindoleacetate
## -----------------------------
## 5 valores más bajos:
## [1] 3.697016 4.614455 5.230171 5.258179 5.443743
## 5 valores más altos:
## [1] 17.69921 17.79898 18.28805 18.60033 23.86143
## =============================
##
## =============================
## Metabolito: Phenylacetylglutamine(PAGln)
## -----------------------------
## 5 valores más bajos:
## [1] 8.742131 9.270367 10.431757 10.594709 12.294338
## 5 valores más altos:
## [1] 279.8378 287.6428 293.7993 314.3907 318.1968
## =============================
##
## =============================
## Metabolito: Pantothenol
## -----------------------------
## 5 valores más bajos:
## [1] 7.304760 7.355888 7.542456 7.553259 8.409651
## 5 valores más altos:
## [1] 17.17340 17.58477 17.60504 19.52724 20.65449
## =============================
##
## =============================
## Metabolito: Putrescine
## -----------------------------
## 5 valores más bajos:
## [1] 21325.38 23502.27 24803.06 24965.04 25206.31
## 5 valores más altos:
## [1] 66363.96 66944.33 69826.26 69949.20 77425.23
## =============================
##
## =============================
## Metabolito: Gamma-aminobutyric acid
## -----------------------------
## 5 valores más bajos:
## [1] 1890.206 2454.045 2721.003 2780.618 2811.942
## 5 valores más altos:
## [1] 15476.89 16833.87 20989.08 23217.95 30914.50
## =============================
##
## =============================
## Metabolito: 5-Aminopentanoic acid
## -----------------------------
## 5 valores más bajos:
## [1] 684.6720 844.3671 886.8052 935.5768 987.3869
## 5 valores más altos:
## [1] 2989.081 3283.116 3324.622 3913.091 4541.054
## =============================
##
## =============================
## Metabolito: N-Acetylcadaverine
## -----------------------------
## 5 valores más bajos:
## [1] 1.714805 1.783293 1.838097 1.924388 1.951595
## 5 valores más altos:
## [1] 4.330323 4.411770 4.720073 4.871417 4.968915
## =============================
##
## =============================
## Metabolito: Acetylcholine
## -----------------------------
## 5 valores más bajos:
## [1] 49.44254 50.93094 62.51013 62.84045 63.18180
## 5 valores más altos:
## [1] 152.0745 153.8035 154.5620 158.8418 160.6692
## =============================
##
## =============================
## Metabolito: Spermidine
## -----------------------------
## 5 valores más bajos:
## [1] 2.397422 2.411093 2.793463 2.823821 2.997923
## 5 valores más altos:
## [1] 12.11940 12.74874 14.59607 15.96565 36.84516
## =============================
##
## =============================
## Metabolito: N-acetyl-aspartic acid
## -----------------------------
## 5 valores más bajos:
## [1] 17.05359 17.77065 18.95212 19.30988 19.61306
## 5 valores más altos:
## [1] 67.83021 70.07769 71.16170 71.53495 84.87211
## =============================
##
## =============================
## Metabolito: N8-Acetylspermidine
## -----------------------------
## 5 valores más bajos:
## [1] 0.5832653 0.7288654 0.7350710 0.7570646 0.8724367
## 5 valores más altos:
## [1] 19.77893 20.93390 26.86770 28.69640 66.01331
## =============================
##
## =============================
## Metabolito: Spermine
## -----------------------------
## 5 valores más bajos:
## [1] 0.5367652 0.5799574 0.6153531 0.7991118 0.9518919
## 5 valores más altos:
## [1] 16.83191 17.92590 18.63602 41.72760 46.70312
## =============================
##
## =============================
## Metabolito: Phenol
## -----------------------------
## 5 valores más bajos:
## [1] 126.0115 152.7430 156.7397 164.3892 208.9915
## 5 valores más altos:
## [1] 7283.211 7741.817 7954.794 9075.045 15171.689
## =============================
##
## =============================
## Metabolito: p-Cresol
## -----------------------------
## 5 valores más bajos:
## [1] 1.339711 2.616872 4.157670 10.109448 15.103459
## 5 valores más altos:
## [1] 3850.458 3946.968 3947.937 4011.642 4214.361
## =============================
##
## =============================
## Metabolito: 1,5-Anhydrosorbitol
## -----------------------------
## 5 valores más bajos:
## [1] 201.3110 255.6220 295.1097 299.2928 331.3875
## 5 valores más altos:
## [1] 3163.016 3168.556 3431.239 3963.469 4294.927
## =============================
##
## =============================
## Metabolito: Benzoic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.003133749 0.003163379 0.003180158 0.003231373 0.003342644
## 5 valores más altos:
## [1] 19.13338 19.23426 20.18578 23.03838 30.00995
## =============================
##
## =============================
## Metabolito: Phenylacetic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.1637998 0.1764631 0.2859984 0.4880197 0.5359696
## 5 valores más altos:
## [1] 51.27457 68.14991 77.51295 93.40758 104.46523
## =============================
##
## =============================
## Metabolito: 3-Hydroxybenzoic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.01382651 0.02552788 0.04096041 0.04345214 0.06391079
## 5 valores más altos:
## [1] 2.756631 3.109867 3.475923 4.623059 7.002539
## =============================
##
## =============================
## Metabolito: 4-Hydroxybenzoic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.3716310 0.4491777 0.4801331 0.4933592 0.6507818
## 5 valores más altos:
## [1] 52.00579 581.67348 663.85529 856.68723 1067.92192
## =============================
##
## =============================
## Metabolito: Salicylic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.4682070 0.5362183 0.5933429 0.5947354 0.5955560
## 5 valores más altos:
## [1] 39.0871 392.6561 490.9007 650.7184 891.2892
## =============================
##
## =============================
## Metabolito: 3-Hydroxyphenylacetic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.3477728 0.4044249 0.8033698 0.8752349 0.9569141
## 5 valores más altos:
## [1] 3470.065 4090.797 5514.470 6017.949 6404.518
## =============================
##
## =============================
## Metabolito: Phenyllactate
## -----------------------------
## 5 valores más bajos:
## [1] 2.363455 3.097057 3.199951 3.313832 3.404422
## 5 valores más altos:
## [1] 17.07521 18.77635 19.22861 22.05143 25.95057
## =============================
##
## =============================
## Metabolito: 4-Hydroxyphenylpropionate
## -----------------------------
## 5 valores más bajos:
## [1] 0.0005270994 0.0005455504 0.0006587474 0.0006940234 0.0007426799
## 5 valores más altos:
## [1] 42.95499 45.41663 48.18734 79.56573 116.41652
## =============================
##
## =============================
## Metabolito: Bilirubin.1
## -----------------------------
## 5 valores más bajos:
## [1] 1902.244 2000.469 2422.857 2587.961 2834.638
## 5 valores más altos:
## [1] 23595.87 23600.51 24788.90 30568.25 35603.07
## =============================
##
## =============================
## Metabolito: 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.1091281 0.1199572 0.1313757 0.1811514 0.1820404
## 5 valores más altos:
## [1] 42.41827 46.63293 49.84514 74.07108 92.99146
## =============================
##
## =============================
## Metabolito: 4-Hydroxyphenyllactate
## -----------------------------
## 5 valores más bajos:
## [1] 12.43217 17.63767 20.49949 21.36074 22.34580
## 5 valores más altos:
## [1] 105.2216 107.6590 111.6004 125.1090 126.1003
## =============================
##
## =============================
## Metabolito: p-Cresol sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 1.816001 4.306643 5.474728 9.025953 10.011919
## 5 valores más altos:
## [1] 1506.320 1548.964 1630.527 1645.139 1864.713
## =============================
##
## =============================
## Metabolito: 2-Hydroxy Hippuric Acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.05142265 0.05294360 0.05690231 0.05840488 0.06069353
## 5 valores más altos:
## [1] 18.95372 55.88637 61.22111 70.91672 150.87155
## =============================
##
## =============================
## Metabolito: 3-Hydroxyhippuric acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.5225184 0.7277195 0.7379476 0.7794253 0.7978474
## 5 valores más altos:
## [1] 36.79265 38.64940 38.77288 51.88400 64.46044
## =============================
##
## =============================
## Metabolito: Sphinganine 1-phosphate
## -----------------------------
## 5 valores más bajos:
## [1] 18.03976 26.81209 27.82046 28.33024 29.28328
## 5 valores más altos:
## [1] 100.6002 101.4774 102.9542 103.3137 114.3119
## =============================
##
## =============================
## Metabolito: Sphingosine 1-phosphate
## -----------------------------
## 5 valores más bajos:
## [1] 65.10179 74.81071 79.00148 84.98149 86.14428
## 5 valores más altos:
## [1] 328.6773 328.8016 330.8751 343.6202 346.4786
## =============================
##
## =============================
## Metabolito: Cholesterol sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 45.89974 67.15199 70.71682 72.62132 78.55322
## 5 valores más altos:
## [1] 1595.113 1718.194 1776.521 2434.132 2726.409
## =============================
##
## =============================
## Metabolito: Xanthurenic acid
## -----------------------------
## 5 valores más bajos:
## [1] 0.8500266 1.0241815 1.0305313 1.0444948 1.0505727
## 5 valores más altos:
## [1] 2.300625 2.324541 2.325488 2.348347 2.449361
## =============================
##
## =============================
## Metabolito: Cinnamoylglycine
## -----------------------------
## 5 valores más bajos:
## [1] 0.03965993 0.08584865 0.08651670 0.11983227 0.13511158
## 5 valores más altos:
## [1] 8.872479 9.598012 10.324135 12.381418 12.889956
## =============================
##
## =============================
## Metabolito: Indoxyl sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 21.39689 22.72586 26.22720 27.71437 30.43438
## 5 valores más altos:
## [1] 654.4307 674.1282 726.2184 782.4124 831.1750
## =============================
##
## =============================
## Metabolito: Ascorbic acid
## -----------------------------
## 5 valores más bajos:
## [1] 359.7330 452.6359 479.3734 499.7808 521.3683
## 5 valores más altos:
## [1] 4855.571 5060.751 5124.203 5305.132 6498.128
## =============================
##
## =============================
## Metabolito: p-Cresol glucuronide
## -----------------------------
## 5 valores más bajos:
## [1] 0.01701031 0.03099466 0.03469214 0.05048839 0.05227809
## 5 valores más altos:
## [1] 15.87612 16.37369 16.62597 17.45696 29.50696
## =============================
##
## =============================
## Metabolito: Homovanillic acid sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 0.2130564 0.3190924 0.3333168 0.3650628 0.3680655
## 5 valores más altos:
## [1] 18.54218 18.59916 25.85226 30.88424 47.63094
## =============================
##
## =============================
## Metabolito: Iodide
## -----------------------------
## 5 valores más bajos:
## [1] 1.226249 1.426229 1.648442 1.668980 1.830278
## 5 valores más altos:
## [1] 9.252034 9.342940 10.146876 11.053438 12.066589
## =============================
##
## =============================
## Metabolito: Phenyl sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 18.74240 22.00960 30.35392 31.51359 34.18436
## 5 valores más altos:
## [1] 1553.756 1754.708 2122.180 3482.864 10227.993
## =============================
##
## =============================
## Metabolito: 4-Ethylphenyl sulfate
## -----------------------------
## 5 valores más bajos:
## [1] 0.7902872 13.2714051 19.3596942 20.2356616 20.2408592
## 5 valores más altos:
## [1] 14579.55 16049.57 17584.21 18641.85 34948.01
## =============================
##
## =============================
## Metabolito: 4-Hydroxybenzoic acid-4-O-sulphate
## -----------------------------
## 5 valores más bajos:
## [1] 2.609838 2.841405 3.543056 3.607999 3.650215
## 5 valores más altos:
## [1] 14.09895 14.52537 14.88750 15.25553 16.31520
## =============================
##
## =============================
## Metabolito: 3-Hydroxypropionic acid
## -----------------------------
## 5 valores más bajos:
## [1] 117.1291 123.0926 137.3995 137.4648 138.1665
## 5 valores más altos:
## [1] 667.9347 673.0662 707.2189 739.0310 824.9149
## =============================
##
## =============================
## Metabolito: Acetylglycine
## -----------------------------
## 5 valores más bajos:
## [1] 21.77186 23.47778 23.57417 24.32103 26.24091
## 5 valores más altos:
## [1] 178.2973 185.7095 198.5382 228.7291 296.8699
## =============================
##
## =============================
## Metabolito: Hippuric acid
## -----------------------------
## 5 valores más bajos:
## [1] 1.382515 6.306937 6.845014 7.200602 7.239262
## 5 valores más altos:
## [1] 666.8943 702.4059 741.1267 1210.0800 1811.0167
## =============================
##
## =============================
## Metabolito: Enterolactone
## -----------------------------
## 5 valores más bajos:
## [1] 0.5492885 0.5638246 0.5687511 0.5771678 0.5853223
## 5 valores más altos:
## [1] 2.190079 2.855669 3.701742 5.801185 14.044385
## =============================Unir Baseline + Metabolomics
# Verificar que coincidan el ID de los participantes
all(Baseline_final$`Sample ID` == Metabolomics_t$ID)## [1] TRUETabla 1
Baseline
baseline <- Basecom %>% select(3:34)
# Diccionario de nombres
diccionario = c(
Gender = "Sexo",
Group = "Grupo",
Age = "Edad",
Height = "Altura",
Weight = "Peso",
BMI = "Índice de masa corporal (kg/m²)",
`Waistline (cm)` = "Circunferencia de cintura (cm)",
`SBP (mmHg)` = "Presión sistólica (mm Hg)",
`DBP (mmHg)` = "Presión diastólica (mm Hg)",
`HBA (%)` = "Hemoglobina A1c (%)",
`FBG (mM)` = "Glucosa en ayunas (mM)",
`ALT (U/L)` = "Alanina aminotransferasa (U/L)",
`AST (U/L)` = "Aspartato aminotransferasa (U/L)",
`Urea (mM)` = "Urea (mM)",
`Cre (uM)` = "Creatinina (µM)",
`UA (uM)` = "Ácido úrico (µM)",
`ALB (g/L)` = "Albúmina (g/L)",
`TC (mM)` = "Colesterol total (mM)",
`TG (mM)` = "Triglicéridos (mM)",
`HDL-C (mM)` = "Colesterol HDL (mM)",
`LDL-C (mM)` = "Colesterol LDL (mM)",
`ALP (U/L)` = "Fosfatasa alcalina (U/L)",
#`Υ-GT (U/L)` = "Gamma-GT (U/L)",
`T-BIL (uM)` = "Bilirrubina total (µM)",
`D-BIL (uM)` = "Bilirrubina directa (µM)",
`TBA (uM)` = "Ácidos biliares totales (µM)",
`CHE (U/L)` = "Colinesterasa (U/L)",
`WBC (10^9/L)` = "Leucocitos (10^9/L)",
`NEUT (%)` = "Neutrófilos (%)",
`LYMPH (%)` = "Linfocitos (%)",
`EO (%)` = "Eosinófilos (%)",
`BASO (%)` = "Basófilos (%)"
)
# Renombrar variables usando el diccionario
nombres_originales = names(baseline)
nombres_nuevos = sapply(nombres_originales, function(nombre) {
if (nombre %in% names(diccionario)) {
diccionario[[nombre]]
} else {
nombre # conservar si no está en el diccionario
}
})
names(baseline) = nombres_nuevos
baseline$`Edad categorizada` <- cut(
baseline$Edad,
breaks = c(18, 40, 60, 80, 100),
right = TRUE, # para incluir el límite de rango
labels = c("18–40", "41–60", "61–80", "81–100")
)
# Traduce la variable "Grupo" a etiquetas legibles
baseline <- baseline %>%
mutate(Grupo = case_when(
Grupo == 1 ~ "T2D",
Grupo == 2 ~ "sin T2D",
TRUE ~ as.character(Grupo)
))
# variables continuas y categóricas
vars_continuas <- c("Edad", "Altura", "Peso", "Índice de masa corporal (kg/m²)",
"Circunferencia de cintura (cm)", "Presión sistólica (mm Hg)",
"Presión diastólica (mm Hg)", "Glucosa en ayunas (mM)",
"Colesterol total (mM)", "Triglicéridos (mM)",
"Colesterol HDL (mM)", "Colesterol LDL (mM)",
"Alanina aminotransferasa (U/L)", "Aspartato aminotransferasa (U/L)",
"Urea (mM)", "Creatinina (µM)", "Ácido úrico (µM)", "Albúmina (g/L)",
"Fosfatasa alcalina (U/L)", "Bilirrubina total (µM)",
"Bilirrubina directa (µM)", "Ácidos biliares totales (µM)",
"Colinesterasa (U/L)", "Leucocitos (10^9/L)", "Υ-GT (U/L)")
vars_categoricas <- c("Sexo")
vars_edad <- "Edad categorizada"
vars_porcentuales <- c("Neutrófilos (%)","Linfocitos (%)","Eosinófilos (%)","Basófilos (%)", "Hemoglobina A1c (%)")
# Crear tabla 1 estratificada por Grupo (1 y 2)
tabla1 <- CreateTableOne(vars = c(vars_categoricas, vars_edad, vars_continuas,
vars_porcentuales), strata = "Grupo",
data = baseline, factorVars = vars_categoricas)
# Imprimir tabla SIN columnas p ni test
tabla1_df <- print(tabla1,
showAllLevels = TRUE,
printToggle = FALSE,
noSpaces = TRUE)
# Eliminar columnas p y test si existen
cols_quitar <- c("p", "test")
cols_presentes <- intersect(cols_quitar, colnames(tabla1_df))
if (length(cols_presentes) > 0) {
tabla1_df <- tabla1_df[, !(colnames(tabla1_df) %in% cols_presentes)]
}
#Imprimir tabla
kable(tabla1_df,
format = "html",
caption = "Tabla 1: Biomarcadores estratificados por grupo") %>%
kable_styling(bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center")| level | sin T2D | T2D | |
|---|---|---|---|
| n | 196 | 97 | |
| Sexo (%) | Female | 97 (49.5) | 28 (28.9) |
| Male | 99 (50.5) | 69 (71.1) | |
| Edad categorizada (%) | 18–40 | 67 (34.2) | 20 (20.6) |
| 41–60 | 91 (46.4) | 59 (60.8) | |
| 61–80 | 38 (19.4) | 18 (18.6) | |
| 81–100 | 0 (0.0) | 0 (0.0) | |
| Edad (mean (SD)) | 47.24 (11.64) | 50.30 (11.74) | |
| Altura (mean (SD)) | 167.90 (8.10) | 170.84 (8.62) | |
| Peso (mean (SD)) | 67.71 (13.45) | 80.44 (14.64) | |
| Índice de masa corporal (kg/m²) (mean (SD)) | 23.89 (3.72) | 27.62 (4.01) | |
| Circunferencia de cintura (cm) (mean (SD)) | 79.97 (10.62) | 93.09 (9.92) | |
| Presión sistólica (mm Hg) (mean (SD)) | 121.39 (15.68) | 138.06 (18.57) | |
| Presión diastólica (mm Hg) (mean (SD)) | 74.65 (11.22) | 86.63 (13.19) | |
| Glucosa en ayunas (mM) (mean (SD)) | 5.01 (0.41) | 9.79 (3.22) | |
| Colesterol total (mM) (mean (SD)) | 5.16 (1.93) | 5.30 (1.05) | |
| Triglicéridos (mM) (mean (SD)) | 1.35 (0.76) | 2.39 (2.12) | |
| Colesterol HDL (mM) (mean (SD)) | 1.47 (0.30) | 1.34 (0.35) | |
| Colesterol LDL (mM) (mean (SD)) | 2.66 (0.62) | 2.91 (0.79) | |
| Alanina aminotransferasa (U/L) (mean (SD)) | 20.86 (14.87) | 37.09 (22.09) | |
| Aspartato aminotransferasa (U/L) (mean (SD)) | 20.75 (6.31) | 27.10 (15.28) | |
| Urea (mM) (mean (SD)) | 5.06 (1.30) | 5.37 (1.25) | |
| Creatinina (µM) (mean (SD)) | 65.17 (15.20) | 66.15 (14.78) | |
| Ácido úrico (µM) (mean (SD)) | 338.93 (99.64) | 352.33 (116.06) | |
| Albúmina (g/L) (mean (SD)) | 45.63 (3.28) | 46.57 (3.22) | |
| Fosfatasa alcalina (U/L) (mean (SD)) | 70.39 (19.86) | 85.96 (24.78) | |
| Bilirrubina total (µM) (mean (SD)) | 14.74 (6.83) | 14.52 (5.02) | |
| Bilirrubina directa (µM) (mean (SD)) | 3.96 (1.80) | 3.86 (1.50) | |
| Ácidos biliares totales (µM) (mean (SD)) | 2.75 (2.06) | 3.08 (1.55) | |
| Colinesterasa (U/L) (mean (SD)) | 361.87 (92.26) | 451.05 (75.54) | |
| Leucocitos (10^9/L) (mean (SD)) | 5.56 (1.21) | 6.64 (1.94) | |
| Υ-GT (U/L) (mean (SD)) | 27.92 (26.19) | 45.13 (24.04) | |
| Neutrófilos (%) (mean (SD)) | 56.27 (7.15) | 57.56 (6.95) | |
| Linfocitos (%) (mean (SD)) | 35.08 (7.07) | 32.22 (7.14) | |
| Eosinófilos (%) (mean (SD)) | 2.22 (1.82) | 1.89 (1.29) | |
| Basófilos (%) (mean (SD)) | 0.49 (0.34) | 0.50 (0.28) | |
| Hemoglobina A1c (%) (mean (SD)) | 5.46 (0.25) | 8.39 (2.02) |
Metabolitos
Metabolitos <- Basecom %>% select(4, 35:ncol(Basecom))
Metabolitos <- Metabolitos %>%
mutate(Group = case_when(
Group == 1 ~ "T2D",
Group == 2 ~ "sin T2D",
TRUE ~ as.character(Group)
))
# Vars continuas
vars_continuas <- names(Metabolitos)[names(Metabolitos) != "Group"]
#Tabla 1
tabla1_M4 <- CreateTableOne(
vars = vars_continuas,
strata = "Group",
data = Metabolitos
)
# Convertir a df
tabla1_M4_df <- print(
tabla1_M4,
printToggle = FALSE,
noSpaces = TRUE
)
# Eliminar columnas p y test si existen
cols_quitar <- c("p", "test")
cols_presentes <- intersect(cols_quitar, colnames(tabla1_M4_df))
if (length(cols_presentes) > 0) {
tabla1_M4_df <- tabla1_M4_df[, !(colnames(tabla1_M4_df) %in% cols_presentes)]
}
# Mostrar tabla
kable(tabla1_M4_df,
format = "html",
caption = "Tabla 1: Metabolitos estratificados por grupo"
) %>%
kable_styling(
bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center"
)| sin T2D | T2D | |
|---|---|---|
| n | 196 | 97 |
| Phenylethylamine (mean (SD)) | 0.19 (0.22) | 0.36 (0.69) |
| Octadecanamide (mean (SD)) | 2.56 (2.55) | 2.75 (2.70) |
| Urocanic acid (mean (SD)) | 4.37 (7.80) | 5.18 (4.39) |
| Imidazolepropionic acid (mean (SD)) | 33.96 (11.69) | 26.62 (10.60) |
| Indole-3-carboxaldehyde (mean (SD)) | 0.15 (0.04) | 0.11 (0.04) |
| 3-Hydroxyanthranilic acid (mean (SD)) | 9.05 (5.14) | 5.57 (2.49) |
| Dopamine (mean (SD)) | 16.15 (5.92) | 15.10 (5.24) |
| Oleamide (mean (SD)) | 324.44 (280.54) | 292.79 (327.75) |
| Oleoylethanolamide (mean (SD)) | 0.93 (0.22) | 0.76 (0.20) |
| Palmitic amide (mean (SD)) | 6.73 (5.19) | 5.84 (4.33) |
| Palmitoylethanolamide (mean (SD)) | 0.99 (0.31) | 0.93 (0.31) |
| Stearoylethanolamide (mean (SD)) | 2.83 (1.46) | 1.46 (0.47) |
| Bilirubin (mean (SD)) | 26154.49 (12260.54) | 27589.36 (11065.18) |
| Biliverdin (mean (SD)) | 35.16 (18.20) | 40.33 (19.63) |
| Indole-3-acrylic acid (mean (SD)) | 0.49 (0.87) | 0.60 (1.14) |
| Kynurenic acid (mean (SD)) | 1.75 (0.56) | 1.92 (0.62) |
| Indole-3-propionic acid (mean (SD)) | 171.10 (489.81) | 154.36 (455.04) |
| Indole-3-methyl acetate (mean (SD)) | 16.51 (46.34) | 15.33 (45.97) |
| Dopa (mean (SD)) | 122.52 (61.26) | 57.01 (35.82) |
| Sphinganine (mean (SD)) | 1.01 (0.38) | 1.15 (0.52) |
| Sphinganine-1-phosphate (mean (SD)) | 73.32 (14.46) | 53.78 (15.08) |
| Sphingosine (mean (SD)) | 2.92 (0.87) | 3.83 (1.53) |
| 3-Indolebutyric acid (mean (SD)) | 0.54 (0.31) | 0.46 (0.27) |
| Sphingosine-1-phosphate (mean (SD)) | 177.80 (19.75) | 155.24 (28.29) |
| 5-Methoxyindoleacetate (mean (SD)) | 8.91 (2.57) | 11.13 (2.45) |
| Phenylacetylglutamine(PAGln) (mean (SD)) | 81.21 (64.60) | 79.47 (65.86) |
| Pantothenol (mean (SD)) | 12.39 (2.02) | 12.90 (2.17) |
| Putrescine (mean (SD)) | 46985.71 (9762.55) | 36393.30 (7566.16) |
| Gamma-aminobutyric acid (mean (SD)) | 6773.31 (2506.11) | 8741.13 (4499.99) |
| 5-Aminopentanoic acid (mean (SD)) | 1714.31 (417.31) | 1964.97 (634.63) |
| N-Acetylcadaverine (mean (SD)) | 3.05 (0.61) | 3.10 (0.42) |
| Acetylcholine (mean (SD)) | 99.74 (20.18) | 102.43 (21.07) |
| Spermidine (mean (SD)) | 5.66 (1.81) | 6.75 (3.90) |
| N-acetyl-aspartic acid (mean (SD)) | 40.76 (11.80) | 35.44 (9.65) |
| N8-Acetylspermidine (mean (SD)) | 5.38 (3.86) | 5.57 (7.19) |
| Spermine (mean (SD)) | 5.03 (3.89) | 4.67 (4.87) |
| Phenol (mean (SD)) | 1640.12 (1761.24) | 1625.01 (1623.06) |
| p-Cresol (mean (SD)) | 921.80 (893.58) | 784.97 (908.85) |
| 1,5-Anhydrosorbitol (mean (SD)) | 1258.86 (568.77) | 1953.17 (698.95) |
| Benzoic acid (mean (SD)) | 7.60 (4.45) | 8.12 (5.63) |
| Phenylacetic acid (mean (SD)) | 15.03 (14.35) | 13.46 (9.65) |
| 3-Hydroxybenzoic acid (mean (SD)) | 0.93 (0.77) | 0.83 (0.55) |
| 4-Hydroxybenzoic acid (mean (SD)) | 11.04 (76.08) | 27.41 (122.72) |
| Salicylic acid (mean (SD)) | 8.07 (63.51) | 18.63 (90.53) |
| 3-Hydroxyphenylacetic acid (mean (SD)) | 527.16 (863.68) | 315.19 (761.83) |
| Phenyllactate (mean (SD)) | 7.61 (2.96) | 9.46 (3.32) |
| 4-Hydroxyphenylpropionate (mean (SD)) | 5.36 (8.72) | 5.95 (13.14) |
| Bilirubin.1 (mean (SD)) | 8312.73 (4814.32) | 11548.14 (4477.27) |
| 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid (mean (SD)) | 5.55 (8.41) | 8.06 (13.23) |
| 4-Hydroxyphenyllactate (mean (SD)) | 47.32 (18.51) | 60.41 (19.91) |
| p-Cresol sulfate (mean (SD)) | 379.57 (366.48) | 317.37 (351.87) |
| 2-Hydroxy Hippuric Acid (mean (SD)) | 1.32 (10.77) | 2.59 (11.02) |
| 3-Hydroxyhippuric acid (mean (SD)) | 6.65 (8.75) | 7.48 (9.80) |
| Sphinganine 1-phosphate (mean (SD)) | 70.62 (13.26) | 53.73 (15.11) |
| Sphingosine 1-phosphate (mean (SD)) | 186.99 (65.80) | 135.30 (34.37) |
| Cholesterol sulfate (mean (SD)) | 395.07 (332.57) | 460.59 (341.98) |
| Xanthurenic acid (mean (SD)) | 1.59 (0.27) | 1.59 (0.25) |
| Cinnamoylglycine (mean (SD)) | 1.99 (1.99) | 1.73 (1.87) |
| Indoxyl sulfate (mean (SD)) | 205.60 (138.04) | 184.31 (131.22) |
| Ascorbic acid (mean (SD)) | 1560.47 (808.58) | 2863.99 (970.84) |
| p-Cresol glucuronide (mean (SD)) | 2.19 (3.49) | 2.35 (3.17) |
| Homovanillic acid sulfate (mean (SD)) | 2.58 (3.50) | 3.39 (5.90) |
| Iodide (mean (SD)) | 4.05 (1.46) | 4.01 (1.37) |
| Phenyl sulfate (mean (SD)) | 325.88 (325.66) | 440.71 (1092.59) |
| 4-Ethylphenyl sulfate (mean (SD)) | 1629.38 (2999.83) | 1860.91 (4143.37) |
| 4-Hydroxybenzoic acid-4-O-sulphate (mean (SD)) | 8.04 (2.00) | 6.42 (1.54) |
| 3-Hydroxypropionic acid (mean (SD)) | 277.47 (89.89) | 424.85 (120.77) |
| Acetylglycine (mean (SD)) | 76.58 (37.74) | 60.19 (25.18) |
| Hippuric acid (mean (SD)) | 139.30 (194.72) | 120.63 (144.73) |
| Enterolactone (mean (SD)) | 1.28 (0.99) | 1.25 (0.59) |
Shapiro-test
biomarcadores <- Basecom %>% select(5:ncol(Basecom))
resultados_shapiro <- data.frame(
Variable = names(biomarcadores),
Valor_p = sapply(names(biomarcadores), function(var) {
b <- na.omit(biomarcadores[[var]])
if (is.numeric(b) && length(b) >= 3 && length(b) <= 5000) {
shapiro.test(b)$p.value
} else {
NA
}
})
)
resultados_shapiro$Valor_p <- round(resultados_shapiro$Valor_p, 7)
print(resultados_shapiro)## Variable
## Age Age
## Height Height
## Weight Weight
## BMI BMI
## Waistline (cm) Waistline (cm)
## SBP (mmHg) SBP (mmHg)
## DBP (mmHg) DBP (mmHg)
## HBA (%) HBA (%)
## FBG (mM) FBG (mM)
## ALT (U/L) ALT (U/L)
## AST (U/L) AST (U/L)
## Urea (mM) Urea (mM)
## Cre (uM) Cre (uM)
## UA (uM) UA (uM)
## ALB (g/L) ALB (g/L)
## TC (mM) TC (mM)
## TG (mM) TG (mM)
## HDL-C (mM) HDL-C (mM)
## LDL-C (mM) LDL-C (mM)
## ALP (U/L) ALP (U/L)
## Υ-GT (U/L) Υ-GT (U/L)
## T-BIL (uM) T-BIL (uM)
## D-BIL (uM) D-BIL (uM)
## TBA (uM) TBA (uM)
## CHE (U/L) CHE (U/L)
## WBC (10^9/L) WBC (10^9/L)
## NEUT (%) NEUT (%)
## LYMPH (%) LYMPH (%)
## EO (%) EO (%)
## BASO (%) BASO (%)
## Phenylethylamine Phenylethylamine
## Octadecanamide Octadecanamide
## Urocanic acid Urocanic acid
## Imidazolepropionic acid Imidazolepropionic acid
## Indole-3-carboxaldehyde Indole-3-carboxaldehyde
## 3-Hydroxyanthranilic acid 3-Hydroxyanthranilic acid
## Dopamine Dopamine
## Oleamide Oleamide
## Oleoylethanolamide Oleoylethanolamide
## Palmitic amide Palmitic amide
## Palmitoylethanolamide Palmitoylethanolamide
## Stearoylethanolamide Stearoylethanolamide
## Bilirubin Bilirubin
## Biliverdin Biliverdin
## Indole-3-acrylic acid Indole-3-acrylic acid
## Kynurenic acid Kynurenic acid
## Indole-3-propionic acid Indole-3-propionic acid
## Indole-3-methyl acetate Indole-3-methyl acetate
## Dopa Dopa
## Sphinganine Sphinganine
## Sphinganine-1-phosphate Sphinganine-1-phosphate
## Sphingosine Sphingosine
## 3-Indolebutyric acid 3-Indolebutyric acid
## Sphingosine-1-phosphate Sphingosine-1-phosphate
## 5-Methoxyindoleacetate 5-Methoxyindoleacetate
## Phenylacetylglutamine(PAGln) Phenylacetylglutamine(PAGln)
## Pantothenol Pantothenol
## Putrescine Putrescine
## Gamma-aminobutyric acid Gamma-aminobutyric acid
## 5-Aminopentanoic acid 5-Aminopentanoic acid
## N-Acetylcadaverine N-Acetylcadaverine
## Acetylcholine Acetylcholine
## Spermidine Spermidine
## N-acetyl-aspartic acid N-acetyl-aspartic acid
## N8-Acetylspermidine N8-Acetylspermidine
## Spermine Spermine
## Phenol Phenol
## p-Cresol p-Cresol
## 1,5-Anhydrosorbitol 1,5-Anhydrosorbitol
## Benzoic acid Benzoic acid
## Phenylacetic acid Phenylacetic acid
## 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid
## 4-Hydroxybenzoic acid 4-Hydroxybenzoic acid
## Salicylic acid Salicylic acid
## 3-Hydroxyphenylacetic acid 3-Hydroxyphenylacetic acid
## Phenyllactate Phenyllactate
## 4-Hydroxyphenylpropionate 4-Hydroxyphenylpropionate
## Bilirubin.1 Bilirubin.1
## 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid
## 4-Hydroxyphenyllactate 4-Hydroxyphenyllactate
## p-Cresol sulfate p-Cresol sulfate
## 2-Hydroxy Hippuric Acid 2-Hydroxy Hippuric Acid
## 3-Hydroxyhippuric acid 3-Hydroxyhippuric acid
## Sphinganine 1-phosphate Sphinganine 1-phosphate
## Sphingosine 1-phosphate Sphingosine 1-phosphate
## Cholesterol sulfate Cholesterol sulfate
## Xanthurenic acid Xanthurenic acid
## Cinnamoylglycine Cinnamoylglycine
## Indoxyl sulfate Indoxyl sulfate
## Ascorbic acid Ascorbic acid
## p-Cresol glucuronide p-Cresol glucuronide
## Homovanillic acid sulfate Homovanillic acid sulfate
## Iodide Iodide
## Phenyl sulfate Phenyl sulfate
## 4-Ethylphenyl sulfate 4-Ethylphenyl sulfate
## 4-Hydroxybenzoic acid-4-O-sulphate 4-Hydroxybenzoic acid-4-O-sulphate
## 3-Hydroxypropionic acid 3-Hydroxypropionic acid
## Acetylglycine Acetylglycine
## Hippuric acid Hippuric acid
## Enterolactone Enterolactone
## Valor_p
## Age 0.0002519
## Height 0.0895669
## Weight 0.0007422
## BMI 0.0010670
## Waistline (cm) 0.0061998
## SBP (mmHg) 0.0000112
## DBP (mmHg) 0.0315573
## HBA (%) 0.0000000
## FBG (mM) 0.0000000
## ALT (U/L) 0.0000000
## AST (U/L) 0.0000000
## Urea (mM) 0.0004192
## Cre (uM) 0.0010531
## UA (uM) 0.0016527
## ALB (g/L) 0.0000000
## TC (mM) 0.0000000
## TG (mM) 0.0000000
## HDL-C (mM) 0.3503533
## LDL-C (mM) 0.0000068
## ALP (U/L) 0.0000000
## Υ-GT (U/L) 0.0000000
## T-BIL (uM) 0.0000000
## D-BIL (uM) 0.0000000
## TBA (uM) 0.0000000
## CHE (U/L) 0.0008267
## WBC (10^9/L) 0.0000000
## NEUT (%) 0.2582637
## LYMPH (%) 0.0050653
## EO (%) 0.0000000
## BASO (%) 0.0000000
## Phenylethylamine 0.0000000
## Octadecanamide 0.0000000
## Urocanic acid 0.0000000
## Imidazolepropionic acid 0.0000102
## Indole-3-carboxaldehyde 0.0029826
## 3-Hydroxyanthranilic acid 0.0000000
## Dopamine 0.0000000
## Oleamide 0.0000000
## Oleoylethanolamide 0.0002496
## Palmitic amide 0.0000000
## Palmitoylethanolamide 0.0125227
## Stearoylethanolamide 0.0000000
## Bilirubin 0.0000000
## Biliverdin 0.0000000
## Indole-3-acrylic acid 0.0000000
## Kynurenic acid 0.0000001
## Indole-3-propionic acid 0.0000000
## Indole-3-methyl acetate 0.0000000
## Dopa 0.0000000
## Sphinganine 0.0000000
## Sphinganine-1-phosphate 0.0835181
## Sphingosine 0.0000000
## 3-Indolebutyric acid 0.0000000
## Sphingosine-1-phosphate 0.0008937
## 5-Methoxyindoleacetate 0.0000000
## Phenylacetylglutamine(PAGln) 0.0000000
## Pantothenol 0.0739628
## Putrescine 0.0013821
## Gamma-aminobutyric acid 0.0000000
## 5-Aminopentanoic acid 0.0000000
## N-Acetylcadaverine 0.0074886
## Acetylcholine 0.0001446
## Spermidine 0.0000000
## N-acetyl-aspartic acid 0.0000014
## N8-Acetylspermidine 0.0000000
## Spermine 0.0000000
## Phenol 0.0000000
## p-Cresol 0.0000000
## 1,5-Anhydrosorbitol 0.0000005
## Benzoic acid 0.0000009
## Phenylacetic acid 0.0000000
## 3-Hydroxybenzoic acid 0.0000000
## 4-Hydroxybenzoic acid 0.0000000
## Salicylic acid 0.0000000
## 3-Hydroxyphenylacetic acid 0.0000000
## Phenyllactate 0.0000000
## 4-Hydroxyphenylpropionate 0.0000000
## Bilirubin.1 0.0000000
## 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid 0.0000000
## 4-Hydroxyphenyllactate 0.0000000
## p-Cresol sulfate 0.0000000
## 2-Hydroxy Hippuric Acid 0.0000000
## 3-Hydroxyhippuric acid 0.0000000
## Sphinganine 1-phosphate 0.4966698
## Sphingosine 1-phosphate 0.0000000
## Cholesterol sulfate 0.0000000
## Xanthurenic acid 0.0112662
## Cinnamoylglycine 0.0000000
## Indoxyl sulfate 0.0000000
## Ascorbic acid 0.0000000
## p-Cresol glucuronide 0.0000000
## Homovanillic acid sulfate 0.0000000
## Iodide 0.0000000
## Phenyl sulfate 0.0000000
## 4-Ethylphenyl sulfate 0.0000000
## 4-Hydroxybenzoic acid-4-O-sulphate 0.0000000
## 3-Hydroxypropionic acid 0.0000000
## Acetylglycine 0.0000000
## Hippuric acid 0.0000000
## Enterolactone 0.0000000Distancias de mahalanobis - Baseline
##Excluir variables de texto y biomarcadores de diabetes
baseline1 <- Basecom %>% select(14:34)
# vector de medias
center1 <- colMeans(baseline1)
# matriz de covarianza
cov_matrix1 <- cov(baseline1)
#distancia de mahalanobis
dist_mahal_bline <- mahalanobis(baseline1, center1, cov_matrix1)
# Distancias
boxplot(dist_mahal_bline,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbralBline <- qchisq(0.95, df = ncol(baseline1))
#outliers
outliersBline <- which(dist_mahal_bline > umbralBline)
#Grafico
plot(dist_mahal_bline, pch = 19, col = "steelblue",
main = "Distancia de Mahalanobis, Baseline",
ylab = "D²", xlab = "Observación")
abline(h = umbralBline, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliersBline, dist_mahal_bline[outliersBline],
labels = outliersBline, pos = 3, col = "red")
Distancias de mahalanobis - M4
Metabolomics1 <- Basecom %>% select(35:ncol(Basecom))
# vector de medias
center2 <- colMeans(Metabolomics1)
# matriz de covarianza
cov_matrix2 <- cov(Metabolomics1)
#distancia de mahalanobis
dist_mahal_M1 <- mahalanobis(Metabolomics1, center2, cov_matrix2)
# Distancias
boxplot(dist_mahal_M1,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbralM1 <- qchisq(0.95, df = ncol(Metabolomics1))
#outliers
outliersM1 <- which(dist_mahal_M1 > umbralM1)
#Gráfico
plot(dist_mahal_M1, pch = 19, col = "steelblue",
main = "Distancia de Mahalanobis, Metabolomics",
ylab = "D²", xlab = "Observación")
abline(h = umbralM1, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliersM1, dist_mahal_M1[outliersM1],
labels = outliersM1, pos = 3, col = "red")
Distancias de mahalanobis - Baseline + M4
Bcom <- Basecom %>% select(14:ncol(Basecom))
# vector de medias
center3 <- colMeans(Bcom)
# matriz de covarianza
cov_matrix3 <- cov(Bcom)
#distancia de mahalanobis
dist_mahal_Bcom <- mahalanobis(Bcom, center3, cov_matrix3)
# Distancias
boxplot(dist_mahal_Bcom,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbralBcom <- qchisq(0.95, df = ncol(Bcom))
#outliers
outliersBcom <- which(dist_mahal_Bcom > umbralBcom)
#Gráfico
plot(dist_mahal_Bcom, pch = 19, col = "steelblue",
main = "Distancia de Mahalanobis, base completa",
ylab = "D²", xlab = "Observación")
abline(h = umbralBcom, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliersBcom, dist_mahal_Bcom[outliersBcom],
labels = outliersBcom, pos = 3, col = "red")
Distancias de mahalanobis - Base unida - Both
#Se deben quitar espacios y caracteres especiales de los nombres de cada var
Bcom2 <- Basecom %>% select(13:ncol(Basecom))
names(Bcom2)## [1] "FBG (mM)"
## [2] "ALT (U/L)"
## [3] "AST (U/L)"
## [4] "Urea (mM)"
## [5] "Cre (uM)"
## [6] "UA (uM)"
## [7] "ALB (g/L)"
## [8] "TC (mM)"
## [9] "TG (mM)"
## [10] "HDL-C (mM)"
## [11] "LDL-C (mM)"
## [12] "ALP (U/L)"
## [13] "Υ-GT (U/L)"
## [14] "T-BIL (uM)"
## [15] "D-BIL (uM)"
## [16] "TBA (uM)"
## [17] "CHE (U/L)"
## [18] "WBC (10^9/L)"
## [19] "NEUT (%)"
## [20] "LYMPH (%)"
## [21] "EO (%)"
## [22] "BASO (%)"
## [23] "Phenylethylamine"
## [24] "Octadecanamide"
## [25] "Urocanic acid"
## [26] "Imidazolepropionic acid"
## [27] "Indole-3-carboxaldehyde"
## [28] "3-Hydroxyanthranilic acid"
## [29] "Dopamine"
## [30] "Oleamide"
## [31] "Oleoylethanolamide"
## [32] "Palmitic amide"
## [33] "Palmitoylethanolamide"
## [34] "Stearoylethanolamide"
## [35] "Bilirubin"
## [36] "Biliverdin"
## [37] "Indole-3-acrylic acid"
## [38] "Kynurenic acid"
## [39] "Indole-3-propionic acid"
## [40] "Indole-3-methyl acetate"
## [41] "Dopa"
## [42] "Sphinganine"
## [43] "Sphinganine-1-phosphate"
## [44] "Sphingosine"
## [45] "3-Indolebutyric acid"
## [46] "Sphingosine-1-phosphate"
## [47] "5-Methoxyindoleacetate"
## [48] "Phenylacetylglutamine(PAGln)"
## [49] "Pantothenol"
## [50] "Putrescine"
## [51] "Gamma-aminobutyric acid"
## [52] "5-Aminopentanoic acid"
## [53] "N-Acetylcadaverine"
## [54] "Acetylcholine"
## [55] "Spermidine"
## [56] "N-acetyl-aspartic acid"
## [57] "N8-Acetylspermidine"
## [58] "Spermine"
## [59] "Phenol"
## [60] "p-Cresol"
## [61] "1,5-Anhydrosorbitol"
## [62] "Benzoic acid"
## [63] "Phenylacetic acid"
## [64] "3-Hydroxybenzoic acid"
## [65] "4-Hydroxybenzoic acid"
## [66] "Salicylic acid"
## [67] "3-Hydroxyphenylacetic acid"
## [68] "Phenyllactate"
## [69] "4-Hydroxyphenylpropionate"
## [70] "Bilirubin.1"
## [71] "3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid"
## [72] "4-Hydroxyphenyllactate"
## [73] "p-Cresol sulfate"
## [74] "2-Hydroxy Hippuric Acid"
## [75] "3-Hydroxyhippuric acid"
## [76] "Sphinganine 1-phosphate"
## [77] "Sphingosine 1-phosphate"
## [78] "Cholesterol sulfate"
## [79] "Xanthurenic acid"
## [80] "Cinnamoylglycine"
## [81] "Indoxyl sulfate"
## [82] "Ascorbic acid"
## [83] "p-Cresol glucuronide"
## [84] "Homovanillic acid sulfate"
## [85] "Iodide"
## [86] "Phenyl sulfate"
## [87] "4-Ethylphenyl sulfate"
## [88] "4-Hydroxybenzoic acid-4-O-sulphate"
## [89] "3-Hydroxypropionic acid"
## [90] "Acetylglycine"
## [91] "Hippuric acid"
## [92] "Enterolactone"names(Bcom2) <- make.names(names(Bcom2))
#Como se repiten nombres y no funciona make.unique
names(Bcom2)[names(Bcom2) == "Sphinganine.1.phosphate"][2] <- "S.ganine.1.phosphate_b"
names(Bcom2)[names(Bcom2) == "Sphingosine.1.phosphate"][2] <- "S.gosine.1.phosphate_b"
#S.ganine = Sphinganine
#S.gosine = Sphingosine
#Regresión lineal multiple con fbg
modelo_completo <- lm(FBG..mM. ~ ., data = Bcom2)
#Both
modelo_both <- step(modelo_completo, direction = "both")## Start: AIC=336.79
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Urea..mM. + Cre..uM. + UA..uM. +
## ALB..g.L. + TC..mM. + TG..mM. + HDL.C..mM. + LDL.C..mM. +
## ALP..U.L. + Υ.GT..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + WBC..10.9.L. + NEUT.... + LYMPH.... + EO.... +
## BASO.... + Phenylethylamine + Octadecanamide + Urocanic.acid +
## Imidazolepropionic.acid + Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid +
## Dopamine + Oleamide + Oleoylethanolamide + Palmitic.amide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Biliverdin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + X3.Hydroxyphenylacetic.acid +
## Phenyllactate + X4.Hydroxyphenylpropionate + Bilirubin.1 +
## X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid + X4.Hydroxyphenyllactate +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + S.gosine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## p.Cresol.glucuronide + Homovanillic.acid.sulfate + Iodide +
## Phenyl.sulfate + X4.Ethylphenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid +
## Enterolactone
##
## Df Sum of Sq RSS AIC
## - Biliverdin 1 0.000 493.56 334.79
## - Enterolactone 1 0.001 493.56 334.79
## - LDL.C..mM. 1 0.006 493.56 334.79
## - X3.Hydroxyphenylacetic.acid 1 0.010 493.57 334.79
## - Urea..mM. 1 0.010 493.57 334.79
## - Dopamine 1 0.012 493.57 334.80
## - p.Cresol.glucuronide 1 0.018 493.57 334.80
## - BASO.... 1 0.025 493.58 334.80
## - S.gosine.1.phosphate_b 1 0.030 493.59 334.81
## - X4.Hydroxyphenylpropionate 1 0.041 493.60 334.81
## - Dopa 1 0.048 493.60 334.82
## - X4.Ethylphenyl.sulfate 1 0.051 493.61 334.82
## - WBC..10.9.L. 1 0.066 493.62 334.83
## - Oleoylethanolamide 1 0.083 493.64 334.84
## - Phenylacetic.acid 1 0.096 493.65 334.85
## - Υ.GT..U.L. 1 0.098 493.65 334.85
## - Putrescine 1 0.099 493.66 334.85
## - UA..uM. 1 0.102 493.66 334.85
## - TC..mM. 1 0.156 493.71 334.88
## - Sphingosine 1 0.158 493.71 334.88
## - X4.Hydroxybenzoic.acid 1 0.185 493.74 334.90
## - Palmitic.amide 1 0.189 493.74 334.90
## - Sphingosine.1.phosphate 1 0.233 493.79 334.93
## - CHE..U.L. 1 0.254 493.81 334.94
## - p.Cresol.sulfate 1 0.256 493.81 334.94
## - p.Cresol 1 0.298 493.85 334.97
## - Stearoylethanolamide 1 0.324 493.88 334.98
## - Benzoic.acid 1 0.328 493.88 334.98
## - Indole.3.propionic.acid 1 0.426 493.98 335.04
## - X5.Methoxyindoleacetate 1 0.596 494.15 335.14
## - X3.Hydroxybenzoic.acid 1 0.654 494.21 335.18
## - Spermidine 1 0.701 494.26 335.20
## - Spermine 1 0.743 494.30 335.23
## - X4.Hydroxyphenyllactate 1 0.822 494.38 335.28
## - Iodide 1 0.964 494.52 335.36
## - Salicylic.acid 1 1.036 494.59 335.40
## - Hippuric.acid 1 1.243 494.80 335.53
## - Cre..uM. 1 1.398 494.95 335.62
## - Phenol 1 1.597 495.15 335.74
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.673 495.23 335.78
## - Bilirubin 1 1.998 495.55 335.97
## - Urocanic.acid 1 2.041 495.60 336.00
## - Bilirubin.1 1 2.202 495.76 336.09
## - ALB..g.L. 1 2.247 495.80 336.12
## - ALP..U.L. 1 2.298 495.85 336.15
## - Indole.3.methyl.acetate 1 2.314 495.87 336.16
## - Acetylcholine 1 2.383 495.94 336.20
## - N8.Acetylspermidine 1 2.459 496.02 336.25
## - Sphinganine.1.phosphate 1 2.507 496.06 336.27
## - N.Acetylcadaverine 1 2.912 496.47 336.51
## - TBA..uM. 1 3.241 496.80 336.71
## - Homovanillic.acid.sulfate 1 3.323 496.88 336.75
## - T.BIL..uM. 1 3.347 496.90 336.77
## <none> 493.56 336.79
## - D.BIL..uM. 1 3.635 497.19 336.94
## - EO.... 1 3.958 497.51 337.13
## - Phenyllactate 1 3.990 497.55 337.15
## - Imidazolepropionic.acid 1 4.054 497.61 337.19
## - Cinnamoylglycine 1 4.368 497.92 337.37
## - X2.Hydroxy.Hippuric.Acid 1 4.471 498.03 337.43
## - Indoxyl.sulfate 1 4.638 498.19 337.53
## - N.acetyl.aspartic.acid 1 5.073 498.63 337.78
## - Phenylacetylglutamine.PAGln. 1 5.122 498.68 337.81
## - Phenylethylamine 1 5.653 499.21 338.13
## - Cholesterol.sulfate 1 5.814 499.37 338.22
## - X3.Hydroxyhippuric.acid 1 7.038 500.59 338.94
## - X3.Hydroxyanthranilic.acid 1 7.199 500.75 339.03
## - Xanthurenic.acid 1 7.402 500.96 339.15
## - Oleamide 1 7.713 501.27 339.33
## - Kynurenic.acid 1 7.713 501.27 339.33
## - Octadecanamide 1 7.743 501.30 339.35
## - Gamma.aminobutyric.acid 1 7.963 501.52 339.48
## - Indole.3.carboxaldehyde 1 8.229 501.78 339.63
## - S.ganine.1.phosphate_b 1 9.596 503.15 340.43
## - Ascorbic.acid 1 10.029 503.59 340.68
## - Sphinganine 1 10.057 503.61 340.70
## - LYMPH.... 1 10.535 504.09 340.98
## - NEUT.... 1 10.769 504.33 341.11
## - AST..U.L. 1 13.089 506.64 342.46
## - X5.Aminopentanoic.acid 1 13.964 507.52 342.96
## - Acetylglycine 1 13.990 507.55 342.98
## - Phenyl.sulfate 1 15.555 509.11 343.88
## - Pantothenol 1 16.607 510.16 344.49
## - ALT..U.L. 1 20.337 513.89 346.62
## - X3.Hydroxypropionic.acid 1 21.407 514.96 347.23
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.477 516.03 347.84
## - X1.5.Anhydrosorbitol 1 23.115 516.67 348.20
## - Palmitoylethanolamide 1 23.556 517.11 348.45
## - Indole.3.acrylic.acid 1 23.764 517.32 348.57
## - HDL.C..mM. 1 24.032 517.59 348.72
## - X3.Indolebutyric.acid 1 47.985 541.54 361.97
## - TG..mM. 1 61.731 555.29 369.32
##
## Step: AIC=334.79
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Urea..mM. + Cre..uM. + UA..uM. +
## ALB..g.L. + TC..mM. + TG..mM. + HDL.C..mM. + LDL.C..mM. +
## ALP..U.L. + Υ.GT..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + WBC..10.9.L. + NEUT.... + LYMPH.... + EO.... +
## BASO.... + Phenylethylamine + Octadecanamide + Urocanic.acid +
## Imidazolepropionic.acid + Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid +
## Dopamine + Oleamide + Oleoylethanolamide + Palmitic.amide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + X3.Hydroxyphenylacetic.acid +
## Phenyllactate + X4.Hydroxyphenylpropionate + Bilirubin.1 +
## X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid + X4.Hydroxyphenyllactate +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + S.gosine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## p.Cresol.glucuronide + Homovanillic.acid.sulfate + Iodide +
## Phenyl.sulfate + X4.Ethylphenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid +
## Enterolactone
##
## Df Sum of Sq RSS AIC
## - Enterolactone 1 0.001 493.56 332.79
## - LDL.C..mM. 1 0.006 493.56 332.79
## - X3.Hydroxyphenylacetic.acid 1 0.010 493.57 332.79
## - Urea..mM. 1 0.011 493.57 332.80
## - Dopamine 1 0.012 493.57 332.80
## - p.Cresol.glucuronide 1 0.018 493.57 332.80
## - BASO.... 1 0.024 493.58 332.80
## - S.gosine.1.phosphate_b 1 0.030 493.59 332.81
## - X4.Hydroxyphenylpropionate 1 0.041 493.60 332.81
## - Dopa 1 0.049 493.61 332.82
## - X4.Ethylphenyl.sulfate 1 0.051 493.61 332.82
## - WBC..10.9.L. 1 0.067 493.62 332.83
## - Oleoylethanolamide 1 0.087 493.64 332.84
## - Υ.GT..U.L. 1 0.098 493.65 332.85
## - Phenylacetic.acid 1 0.098 493.65 332.85
## - Putrescine 1 0.099 493.66 332.85
## - UA..uM. 1 0.102 493.66 332.85
## - TC..mM. 1 0.157 493.71 332.88
## - Sphingosine 1 0.159 493.71 332.88
## - X4.Hydroxybenzoic.acid 1 0.185 493.74 332.90
## - Palmitic.amide 1 0.190 493.75 332.90
## - Sphingosine.1.phosphate 1 0.234 493.79 332.93
## - CHE..U.L. 1 0.254 493.81 332.94
## - p.Cresol.sulfate 1 0.258 493.81 332.94
## - p.Cresol 1 0.302 493.86 332.97
## - Stearoylethanolamide 1 0.329 493.88 332.98
## - Benzoic.acid 1 0.330 493.89 332.98
## - Indole.3.propionic.acid 1 0.432 493.99 333.05
## - X5.Methoxyindoleacetate 1 0.603 494.16 333.15
## - X3.Hydroxybenzoic.acid 1 0.657 494.21 333.18
## - Spermidine 1 0.740 494.30 333.23
## - Spermine 1 0.743 494.30 333.23
## - X4.Hydroxyphenyllactate 1 0.825 494.38 333.28
## - Iodide 1 0.964 494.52 333.36
## - Salicylic.acid 1 1.036 494.59 333.40
## - Hippuric.acid 1 1.246 494.80 333.53
## - Cre..uM. 1 1.398 494.95 333.62
## - Phenol 1 1.606 495.16 333.74
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.782 495.34 333.85
## - Bilirubin 1 2.025 495.58 333.99
## - Urocanic.acid 1 2.050 495.61 334.00
## - ALP..U.L. 1 2.307 495.86 334.16
## - Indole.3.methyl.acetate 1 2.353 495.91 334.18
## - Acetylcholine 1 2.384 495.94 334.20
## - ALB..g.L. 1 2.386 495.94 334.20
## - N8.Acetylspermidine 1 2.460 496.02 334.25
## - Sphinganine.1.phosphate 1 2.527 496.08 334.29
## - N.Acetylcadaverine 1 2.927 496.48 334.52
## - Bilirubin.1 1 3.166 496.72 334.66
## - TBA..uM. 1 3.243 496.80 334.71
## - Homovanillic.acid.sulfate 1 3.325 496.88 334.76
## <none> 493.56 334.79
## - T.BIL..uM. 1 3.518 497.07 334.87
## - D.BIL..uM. 1 3.640 497.20 334.94
## - EO.... 1 3.963 497.52 335.13
## - Imidazolepropionic.acid 1 4.078 497.63 335.20
## - Phenyllactate 1 4.110 497.67 335.22
## - Cinnamoylglycine 1 4.392 497.95 335.38
## - X2.Hydroxy.Hippuric.Acid 1 4.476 498.03 335.43
## - Indoxyl.sulfate 1 4.762 498.32 335.60
## - N.acetyl.aspartic.acid 1 5.077 498.63 335.79
## - Phenylacetylglutamine.PAGln. 1 5.127 498.68 335.82
## - Phenylethylamine 1 5.662 499.22 336.13
## - Cholesterol.sulfate 1 5.827 499.38 336.23
## + Biliverdin 1 0.000 493.56 336.79
## - X3.Hydroxyanthranilic.acid 1 7.199 500.75 337.03
## - X3.Hydroxyhippuric.acid 1 7.216 500.77 337.04
## - Xanthurenic.acid 1 7.444 501.00 337.18
## - Kynurenic.acid 1 7.797 501.35 337.38
## - Octadecanamide 1 7.816 501.37 337.39
## - Oleamide 1 7.881 501.44 337.43
## - Gamma.aminobutyric.acid 1 7.964 501.52 337.48
## - Indole.3.carboxaldehyde 1 8.241 501.80 337.64
## - S.ganine.1.phosphate_b 1 9.654 503.21 338.46
## - Ascorbic.acid 1 10.278 503.83 338.83
## - Sphinganine 1 10.279 503.83 338.83
## - LYMPH.... 1 10.636 504.19 339.04
## - NEUT.... 1 10.854 504.41 339.16
## - AST..U.L. 1 13.153 506.71 340.50
## - X5.Aminopentanoic.acid 1 14.115 507.67 341.05
## - Acetylglycine 1 14.319 507.87 341.17
## - Phenyl.sulfate 1 15.612 509.17 341.91
## - Pantothenol 1 16.629 510.18 342.50
## - ALT..U.L. 1 20.349 513.91 344.63
## - X3.Hydroxypropionic.acid 1 21.422 514.98 345.24
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.568 516.12 345.89
## - X1.5.Anhydrosorbitol 1 23.179 516.73 346.24
## - Indole.3.acrylic.acid 1 23.764 517.32 346.57
## - HDL.C..mM. 1 24.032 517.59 346.72
## - Palmitoylethanolamide 1 24.366 517.92 346.91
## - X3.Indolebutyric.acid 1 48.146 541.70 360.06
## - TG..mM. 1 61.759 555.31 367.33
##
## Step: AIC=332.79
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Urea..mM. + Cre..uM. + UA..uM. +
## ALB..g.L. + TC..mM. + TG..mM. + HDL.C..mM. + LDL.C..mM. +
## ALP..U.L. + Υ.GT..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + WBC..10.9.L. + NEUT.... + LYMPH.... + EO.... +
## BASO.... + Phenylethylamine + Octadecanamide + Urocanic.acid +
## Imidazolepropionic.acid + Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid +
## Dopamine + Oleamide + Oleoylethanolamide + Palmitic.amide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + X3.Hydroxyphenylacetic.acid +
## Phenyllactate + X4.Hydroxyphenylpropionate + Bilirubin.1 +
## X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid + X4.Hydroxyphenyllactate +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + S.gosine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## p.Cresol.glucuronide + Homovanillic.acid.sulfate + Iodide +
## Phenyl.sulfate + X4.Ethylphenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - LDL.C..mM. 1 0.006 493.56 330.79
## - X3.Hydroxyphenylacetic.acid 1 0.010 493.57 330.80
## - Urea..mM. 1 0.010 493.57 330.80
## - Dopamine 1 0.012 493.57 330.80
## - p.Cresol.glucuronide 1 0.017 493.57 330.80
## - BASO.... 1 0.024 493.58 330.80
## - S.gosine.1.phosphate_b 1 0.030 493.59 330.81
## - X4.Hydroxyphenylpropionate 1 0.041 493.60 330.81
## - Dopa 1 0.050 493.61 330.82
## - X4.Ethylphenyl.sulfate 1 0.052 493.61 330.82
## - WBC..10.9.L. 1 0.067 493.62 330.83
## - Oleoylethanolamide 1 0.086 493.64 330.84
## - Υ.GT..U.L. 1 0.098 493.66 330.85
## - Phenylacetic.acid 1 0.099 493.66 330.85
## - UA..uM. 1 0.101 493.66 330.85
## - Putrescine 1 0.102 493.66 330.85
## - TC..mM. 1 0.157 493.71 330.88
## - Sphingosine 1 0.159 493.72 330.88
## - X4.Hydroxybenzoic.acid 1 0.184 493.74 330.90
## - Palmitic.amide 1 0.193 493.75 330.90
## - Sphingosine.1.phosphate 1 0.234 493.79 330.93
## - CHE..U.L. 1 0.258 493.81 330.94
## - p.Cresol.sulfate 1 0.258 493.82 330.94
## - p.Cresol 1 0.300 493.86 330.97
## - Benzoic.acid 1 0.329 493.89 330.98
## - Stearoylethanolamide 1 0.330 493.89 330.99
## - Indole.3.propionic.acid 1 0.437 493.99 331.05
## - X5.Methoxyindoleacetate 1 0.609 494.17 331.15
## - X3.Hydroxybenzoic.acid 1 0.663 494.22 331.18
## - Spermidine 1 0.743 494.30 331.23
## - Spermine 1 0.744 494.30 331.23
## - X4.Hydroxyphenyllactate 1 0.832 494.39 331.28
## - Iodide 1 0.968 494.53 331.36
## - Salicylic.acid 1 1.036 494.59 331.40
## - Hippuric.acid 1 1.246 494.80 331.53
## - Cre..uM. 1 1.403 494.96 331.62
## - Phenol 1 1.618 495.18 331.75
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.791 495.35 331.85
## - Bilirubin 1 2.024 495.58 331.99
## - Urocanic.acid 1 2.049 495.61 332.00
## - ALP..U.L. 1 2.320 495.88 332.16
## - Indole.3.methyl.acetate 1 2.370 495.93 332.19
## - Acetylcholine 1 2.387 495.94 332.20
## - ALB..g.L. 1 2.411 495.97 332.22
## - N8.Acetylspermidine 1 2.461 496.02 332.25
## - Sphinganine.1.phosphate 1 2.534 496.09 332.29
## - N.Acetylcadaverine 1 2.947 496.50 332.53
## - Bilirubin.1 1 3.166 496.72 332.66
## - TBA..uM. 1 3.259 496.82 332.72
## - Homovanillic.acid.sulfate 1 3.324 496.88 332.76
## <none> 493.56 332.79
## - T.BIL..uM. 1 3.525 497.08 332.87
## - D.BIL..uM. 1 3.642 497.20 332.94
## - EO.... 1 3.962 497.52 333.13
## - Imidazolepropionic.acid 1 4.081 497.64 333.20
## - Phenyllactate 1 4.130 497.69 333.23
## - Cinnamoylglycine 1 4.393 497.95 333.39
## - X2.Hydroxy.Hippuric.Acid 1 4.484 498.04 333.44
## - Indoxyl.sulfate 1 4.798 498.36 333.62
## - N.acetyl.aspartic.acid 1 5.106 498.66 333.81
## - Phenylacetylglutamine.PAGln. 1 5.126 498.68 333.82
## - Phenylethylamine 1 5.660 499.22 334.13
## - Cholesterol.sulfate 1 5.825 499.38 334.23
## + Enterolactone 1 0.001 493.56 334.79
## + Biliverdin 1 0.000 493.56 334.79
## - X3.Hydroxyhippuric.acid 1 7.227 500.78 335.05
## - X3.Hydroxyanthranilic.acid 1 7.231 500.79 335.05
## - Xanthurenic.acid 1 7.462 501.02 335.19
## - Kynurenic.acid 1 7.800 501.36 335.38
## - Octadecanamide 1 7.876 501.43 335.43
## - Oleamide 1 7.880 501.44 335.43
## - Gamma.aminobutyric.acid 1 7.965 501.52 335.48
## - Indole.3.carboxaldehyde 1 8.242 501.80 335.64
## - S.ganine.1.phosphate_b 1 9.715 503.27 336.50
## - Sphinganine 1 10.278 503.84 336.83
## - Ascorbic.acid 1 10.351 503.91 336.87
## - LYMPH.... 1 10.637 504.19 337.04
## - NEUT.... 1 10.857 504.41 337.16
## - AST..U.L. 1 13.155 506.71 338.50
## - X5.Aminopentanoic.acid 1 14.115 507.67 339.05
## - Acetylglycine 1 14.380 507.94 339.20
## - Phenyl.sulfate 1 15.646 509.20 339.93
## - Pantothenol 1 16.842 510.40 340.62
## - ALT..U.L. 1 20.348 513.91 342.63
## - X3.Hydroxypropionic.acid 1 21.427 514.98 343.24
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.568 516.12 343.89
## - X1.5.Anhydrosorbitol 1 23.324 516.88 344.32
## - Indole.3.acrylic.acid 1 23.811 517.37 344.59
## - HDL.C..mM. 1 24.097 517.65 344.76
## - Palmitoylethanolamide 1 24.365 517.92 344.91
## - X3.Indolebutyric.acid 1 48.146 541.70 358.06
## - TG..mM. 1 61.852 555.41 365.38
##
## Step: AIC=330.79
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Urea..mM. + Cre..uM. + UA..uM. +
## ALB..g.L. + TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. +
## Υ.GT..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. +
## WBC..10.9.L. + NEUT.... + LYMPH.... + EO.... + BASO.... +
## Phenylethylamine + Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Dopamine +
## Oleamide + Oleoylethanolamide + Palmitic.amide + Palmitoylethanolamide +
## Stearoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Dopa + Sphinganine + Sphinganine.1.phosphate + Sphingosine +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## Phenylacetic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + X3.Hydroxyphenylacetic.acid + Phenyllactate +
## X4.Hydroxyphenylpropionate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + p.Cresol.glucuronide +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Urea..mM. 1 0.009 493.57 328.80
## - X3.Hydroxyphenylacetic.acid 1 0.010 493.57 328.80
## - Dopamine 1 0.011 493.57 328.80
## - p.Cresol.glucuronide 1 0.018 493.58 328.80
## - BASO.... 1 0.025 493.59 328.81
## - S.gosine.1.phosphate_b 1 0.031 493.59 328.81
## - X4.Hydroxyphenylpropionate 1 0.043 493.61 328.82
## - Dopa 1 0.049 493.61 328.82
## - X4.Ethylphenyl.sulfate 1 0.055 493.62 328.83
## - WBC..10.9.L. 1 0.066 493.63 328.83
## - Oleoylethanolamide 1 0.090 493.65 328.85
## - Υ.GT..U.L. 1 0.097 493.66 328.85
## - UA..uM. 1 0.099 493.66 328.85
## - Putrescine 1 0.100 493.66 328.85
## - Phenylacetic.acid 1 0.101 493.66 328.85
## - TC..mM. 1 0.154 493.72 328.88
## - Sphingosine 1 0.168 493.73 328.89
## - X4.Hydroxybenzoic.acid 1 0.186 493.75 328.90
## - Palmitic.amide 1 0.190 493.75 328.91
## - Sphingosine.1.phosphate 1 0.233 493.80 328.93
## - p.Cresol.sulfate 1 0.260 493.82 328.95
## - p.Cresol 1 0.299 493.86 328.97
## - CHE..U.L. 1 0.310 493.87 328.98
## - Stearoylethanolamide 1 0.331 493.89 328.99
## - Benzoic.acid 1 0.350 493.91 329.00
## - Indole.3.propionic.acid 1 0.434 494.00 329.05
## - X5.Methoxyindoleacetate 1 0.618 494.18 329.16
## - X3.Hydroxybenzoic.acid 1 0.665 494.23 329.19
## - Spermidine 1 0.758 494.32 329.24
## - Spermine 1 0.760 494.32 329.24
## - X4.Hydroxyphenyllactate 1 0.830 494.39 329.29
## - Iodide 1 0.983 494.55 329.38
## - Salicylic.acid 1 1.037 494.60 329.41
## - Hippuric.acid 1 1.240 494.80 329.53
## - Cre..uM. 1 1.410 494.97 329.63
## - Phenol 1 1.613 495.18 329.75
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.785 495.35 329.85
## - Bilirubin 1 2.026 495.59 329.99
## - Urocanic.acid 1 2.092 495.66 330.03
## - Indole.3.methyl.acetate 1 2.366 495.93 330.19
## - ALP..U.L. 1 2.405 495.97 330.22
## - ALB..g.L. 1 2.405 495.97 330.22
## - Acetylcholine 1 2.412 495.98 330.22
## - N8.Acetylspermidine 1 2.455 496.02 330.25
## - Sphinganine.1.phosphate 1 2.532 496.10 330.29
## - N.Acetylcadaverine 1 2.945 496.51 330.54
## - Bilirubin.1 1 3.198 496.76 330.69
## - TBA..uM. 1 3.288 496.85 330.74
## - Homovanillic.acid.sulfate 1 3.321 496.88 330.76
## <none> 493.56 330.79
## - EO.... 1 3.959 497.52 331.13
## - Imidazolepropionic.acid 1 4.075 497.64 331.20
## - Phenyllactate 1 4.211 497.77 331.28
## - Cinnamoylglycine 1 4.387 497.95 331.39
## - X2.Hydroxy.Hippuric.Acid 1 4.491 498.05 331.45
## - T.BIL..uM. 1 4.671 498.23 331.55
## - D.BIL..uM. 1 4.826 498.39 331.64
## - Indoxyl.sulfate 1 4.826 498.39 331.64
## - N.acetyl.aspartic.acid 1 5.100 498.66 331.81
## - Phenylacetylglutamine.PAGln. 1 5.161 498.72 331.84
## - Phenylethylamine 1 5.861 499.42 332.25
## - Cholesterol.sulfate 1 6.061 499.62 332.37
## + LDL.C..mM. 1 0.006 493.56 332.79
## + Enterolactone 1 0.001 493.56 332.79
## + Biliverdin 1 0.000 493.56 332.79
## - X3.Hydroxyanthranilic.acid 1 7.230 500.79 333.05
## - X3.Hydroxyhippuric.acid 1 7.272 500.84 333.08
## - Xanthurenic.acid 1 7.540 501.10 333.24
## - Kynurenic.acid 1 7.797 501.36 333.39
## - Oleamide 1 7.874 501.44 333.43
## - Octadecanamide 1 7.891 501.45 333.44
## - Gamma.aminobutyric.acid 1 7.983 501.55 333.49
## - Indole.3.carboxaldehyde 1 8.370 501.93 333.72
## - S.ganine.1.phosphate_b 1 9.709 503.27 334.50
## - Ascorbic.acid 1 10.394 503.96 334.90
## - Sphinganine 1 10.825 504.39 335.15
## - LYMPH.... 1 11.190 504.75 335.36
## - NEUT.... 1 11.515 505.08 335.55
## - AST..U.L. 1 13.165 506.73 336.51
## - X5.Aminopentanoic.acid 1 14.122 507.69 337.06
## - Acetylglycine 1 14.637 508.20 337.36
## - Phenyl.sulfate 1 15.651 509.21 337.94
## - Pantothenol 1 17.104 510.67 338.77
## - ALT..U.L. 1 20.734 514.30 340.85
## - X3.Hydroxypropionic.acid 1 21.554 515.12 341.32
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.563 516.13 341.89
## - X1.5.Anhydrosorbitol 1 23.339 516.90 342.33
## - Indole.3.acrylic.acid 1 23.954 517.52 342.68
## - Palmitoylethanolamide 1 24.429 517.99 342.95
## - HDL.C..mM. 1 25.132 518.70 343.35
## - X3.Indolebutyric.acid 1 48.232 541.80 356.11
## - TG..mM. 1 69.089 562.65 367.18
##
## Step: AIC=328.8
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + BASO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Dopamine +
## Oleamide + Oleoylethanolamide + Palmitic.amide + Palmitoylethanolamide +
## Stearoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Dopa + Sphinganine + Sphinganine.1.phosphate + Sphingosine +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## Phenylacetic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + X3.Hydroxyphenylacetic.acid + Phenyllactate +
## X4.Hydroxyphenylpropionate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + p.Cresol.glucuronide +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - X3.Hydroxyphenylacetic.acid 1 0.009 493.58 326.80
## - Dopamine 1 0.012 493.58 326.81
## - p.Cresol.glucuronide 1 0.021 493.59 326.81
## - BASO.... 1 0.023 493.60 326.81
## - S.gosine.1.phosphate_b 1 0.031 493.60 326.82
## - X4.Hydroxyphenylpropionate 1 0.041 493.61 326.82
## - Dopa 1 0.052 493.62 326.83
## - X4.Ethylphenyl.sulfate 1 0.055 493.63 326.83
## - WBC..10.9.L. 1 0.065 493.64 326.84
## - Oleoylethanolamide 1 0.087 493.66 326.85
## - Phenylacetic.acid 1 0.100 493.67 326.86
## - Υ.GT..U.L. 1 0.100 493.67 326.86
## - Putrescine 1 0.100 493.67 326.86
## - UA..uM. 1 0.101 493.67 326.86
## - Sphingosine 1 0.160 493.73 326.89
## - TC..mM. 1 0.164 493.74 326.90
## - X4.Hydroxybenzoic.acid 1 0.186 493.76 326.91
## - Palmitic.amide 1 0.196 493.77 326.92
## - Sphingosine.1.phosphate 1 0.232 493.80 326.94
## - p.Cresol.sulfate 1 0.263 493.84 326.95
## - p.Cresol 1 0.296 493.87 326.97
## - CHE..U.L. 1 0.309 493.88 326.98
## - Stearoylethanolamide 1 0.341 493.91 327.00
## - Benzoic.acid 1 0.354 493.93 327.01
## - Indole.3.propionic.acid 1 0.451 494.02 327.07
## - X5.Methoxyindoleacetate 1 0.614 494.19 327.16
## - X3.Hydroxybenzoic.acid 1 0.694 494.27 327.21
## - Spermidine 1 0.750 494.32 327.24
## - Spermine 1 0.794 494.37 327.27
## - X4.Hydroxyphenyllactate 1 0.821 494.39 327.29
## - Iodide 1 1.033 494.61 327.41
## - Salicylic.acid 1 1.037 494.61 327.41
## - Hippuric.acid 1 1.234 494.81 327.53
## - Cre..uM. 1 1.494 495.07 327.68
## - Phenol 1 1.612 495.18 327.75
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.800 495.37 327.87
## - Bilirubin 1 2.019 495.59 327.99
## - Urocanic.acid 1 2.088 495.66 328.04
## - Acetylcholine 1 2.404 495.98 328.22
## - Indole.3.methyl.acetate 1 2.410 495.98 328.23
## - ALB..g.L. 1 2.412 495.98 328.23
## - ALP..U.L. 1 2.434 496.01 328.24
## - N8.Acetylspermidine 1 2.449 496.02 328.25
## - Sphinganine.1.phosphate 1 2.531 496.10 328.30
## - N.Acetylcadaverine 1 3.008 496.58 328.58
## - Bilirubin.1 1 3.189 496.76 328.69
## - TBA..uM. 1 3.281 496.85 328.74
## - Homovanillic.acid.sulfate 1 3.311 496.88 328.76
## <none> 493.57 328.80
## - EO.... 1 4.000 497.57 329.16
## - Imidazolepropionic.acid 1 4.070 497.64 329.21
## - Phenyllactate 1 4.215 497.79 329.29
## - Cinnamoylglycine 1 4.390 497.96 329.39
## - X2.Hydroxy.Hippuric.Acid 1 4.482 498.05 329.45
## - T.BIL..uM. 1 4.677 498.25 329.56
## - D.BIL..uM. 1 4.827 498.40 329.65
## - Indoxyl.sulfate 1 4.843 498.42 329.66
## - N.acetyl.aspartic.acid 1 5.095 498.67 329.81
## - Phenylacetylglutamine.PAGln. 1 5.248 498.82 329.90
## - Phenylethylamine 1 5.860 499.43 330.26
## - Cholesterol.sulfate 1 6.068 499.64 330.38
## + Urea..mM. 1 0.009 493.56 330.79
## + LDL.C..mM. 1 0.005 493.57 330.80
## + Enterolactone 1 0.001 493.57 330.80
## + Biliverdin 1 0.001 493.57 330.80
## - X3.Hydroxyanthranilic.acid 1 7.226 500.80 331.06
## - X3.Hydroxyhippuric.acid 1 7.283 500.86 331.09
## - Xanthurenic.acid 1 7.546 501.12 331.24
## - Oleamide 1 7.870 501.44 331.43
## - Octadecanamide 1 7.910 501.48 331.46
## - Kynurenic.acid 1 7.944 501.52 331.48
## - Gamma.aminobutyric.acid 1 7.976 501.55 331.50
## - Indole.3.carboxaldehyde 1 8.368 501.94 331.72
## - S.ganine.1.phosphate_b 1 9.700 503.27 332.50
## - Ascorbic.acid 1 10.471 504.04 332.95
## - Sphinganine 1 11.036 504.61 333.28
## - LYMPH.... 1 11.221 504.79 333.39
## - NEUT.... 1 11.506 505.08 333.55
## - AST..U.L. 1 13.161 506.73 334.51
## - X5.Aminopentanoic.acid 1 14.155 507.73 335.08
## - Acetylglycine 1 14.642 508.21 335.36
## - Phenyl.sulfate 1 15.646 509.22 335.94
## - Pantothenol 1 17.095 510.67 336.77
## - ALT..U.L. 1 20.757 514.33 338.87
## - X3.Hydroxypropionic.acid 1 21.645 515.22 339.37
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.880 516.45 340.08
## - X1.5.Anhydrosorbitol 1 23.467 517.04 340.41
## - Indole.3.acrylic.acid 1 23.972 517.54 340.69
## - Palmitoylethanolamide 1 24.421 517.99 340.95
## - HDL.C..mM. 1 25.580 519.15 341.60
## - X3.Indolebutyric.acid 1 48.235 541.81 354.12
## - TG..mM. 1 69.597 563.17 365.45
##
## Step: AIC=326.8
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + BASO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Dopamine +
## Oleamide + Oleoylethanolamide + Palmitic.amide + Palmitoylethanolamide +
## Stearoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Dopa + Sphinganine + Sphinganine.1.phosphate + Sphingosine +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## Phenylacetic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + X4.Hydroxyphenylpropionate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + p.Cresol.glucuronide +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Dopamine 1 0.011 493.59 324.81
## - p.Cresol.glucuronide 1 0.023 493.60 324.82
## - BASO.... 1 0.026 493.61 324.82
## - S.gosine.1.phosphate_b 1 0.031 493.61 324.82
## - X4.Hydroxyphenylpropionate 1 0.039 493.62 324.83
## - Dopa 1 0.054 493.64 324.84
## - X4.Ethylphenyl.sulfate 1 0.064 493.65 324.84
## - WBC..10.9.L. 1 0.072 493.65 324.85
## - Oleoylethanolamide 1 0.086 493.67 324.85
## - Putrescine 1 0.097 493.68 324.86
## - UA..uM. 1 0.105 493.69 324.87
## - Υ.GT..U.L. 1 0.105 493.69 324.87
## - Phenylacetic.acid 1 0.112 493.69 324.87
## - Sphingosine 1 0.156 493.74 324.90
## - TC..mM. 1 0.158 493.74 324.90
## - X4.Hydroxybenzoic.acid 1 0.186 493.77 324.91
## - Palmitic.amide 1 0.203 493.78 324.92
## - Sphingosine.1.phosphate 1 0.239 493.82 324.95
## - p.Cresol.sulfate 1 0.254 493.84 324.95
## - p.Cresol 1 0.317 493.90 324.99
## - CHE..U.L. 1 0.320 493.90 324.99
## - Stearoylethanolamide 1 0.338 493.92 325.00
## - Benzoic.acid 1 0.370 493.95 325.02
## - Indole.3.propionic.acid 1 0.484 494.06 325.09
## - X5.Methoxyindoleacetate 1 0.631 494.21 325.18
## - Spermidine 1 0.772 494.35 325.26
## - Spermine 1 0.786 494.37 325.27
## - X3.Hydroxybenzoic.acid 1 0.794 494.38 325.27
## - X4.Hydroxyphenyllactate 1 0.813 494.39 325.29
## - Salicylic.acid 1 1.038 494.62 325.42
## - Iodide 1 1.041 494.62 325.42
## - Hippuric.acid 1 1.244 494.83 325.54
## - Cre..uM. 1 1.485 495.07 325.68
## - Phenol 1 1.611 495.19 325.76
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.838 495.42 325.89
## - Bilirubin 1 2.010 495.59 325.99
## - Urocanic.acid 1 2.107 495.69 326.05
## - ALB..g.L. 1 2.406 495.99 326.23
## - Acetylcholine 1 2.409 495.99 326.23
## - N8.Acetylspermidine 1 2.443 496.02 326.25
## - ALP..U.L. 1 2.460 496.04 326.26
## - Indole.3.methyl.acetate 1 2.510 496.09 326.29
## - Sphinganine.1.phosphate 1 2.526 496.11 326.30
## - N.Acetylcadaverine 1 3.006 496.59 326.58
## - Bilirubin.1 1 3.198 496.78 326.70
## - TBA..uM. 1 3.329 496.91 326.77
## - Homovanillic.acid.sulfate 1 3.344 496.92 326.78
## <none> 493.58 326.80
## - Imidazolepropionic.acid 1 4.084 497.67 327.22
## - EO.... 1 4.143 497.72 327.25
## - Phenyllactate 1 4.207 497.79 327.29
## - Cinnamoylglycine 1 4.403 497.98 327.41
## - X2.Hydroxy.Hippuric.Acid 1 4.477 498.06 327.45
## - T.BIL..uM. 1 4.670 498.25 327.56
## - D.BIL..uM. 1 4.854 498.44 327.67
## - Indoxyl.sulfate 1 4.865 498.45 327.68
## - Phenylacetylglutamine.PAGln. 1 5.239 498.82 327.90
## - N.acetyl.aspartic.acid 1 5.260 498.84 327.91
## - Phenylethylamine 1 5.862 499.44 328.26
## - Cholesterol.sulfate 1 6.073 499.65 328.39
## + X3.Hydroxyphenylacetic.acid 1 0.009 493.57 328.80
## + Urea..mM. 1 0.008 493.57 328.80
## + LDL.C..mM. 1 0.006 493.58 328.80
## + Enterolactone 1 0.001 493.58 328.80
## + Biliverdin 1 0.000 493.58 328.80
## - X3.Hydroxyhippuric.acid 1 7.286 500.87 329.10
## - X3.Hydroxyanthranilic.acid 1 7.294 500.88 329.10
## - Xanthurenic.acid 1 7.539 501.12 329.25
## - Kynurenic.acid 1 7.984 501.57 329.51
## - Oleamide 1 7.984 501.57 329.51
## - Gamma.aminobutyric.acid 1 7.992 501.57 329.51
## - Octadecanamide 1 8.098 501.68 329.57
## - Indole.3.carboxaldehyde 1 8.385 501.97 329.74
## - S.ganine.1.phosphate_b 1 9.692 503.27 330.50
## - Ascorbic.acid 1 10.619 504.20 331.04
## - Sphinganine 1 11.027 504.61 331.28
## - LYMPH.... 1 11.545 505.13 331.58
## - NEUT.... 1 11.808 505.39 331.73
## - AST..U.L. 1 13.183 506.76 332.53
## - X5.Aminopentanoic.acid 1 14.174 507.75 333.10
## - Acetylglycine 1 14.760 508.34 333.44
## - Phenyl.sulfate 1 15.648 509.23 333.95
## - Pantothenol 1 17.181 510.76 334.83
## - ALT..U.L. 1 20.807 514.39 336.90
## - X3.Hydroxypropionic.acid 1 21.708 515.29 337.41
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.916 516.50 338.10
## - X1.5.Anhydrosorbitol 1 23.733 517.31 338.56
## - Indole.3.acrylic.acid 1 24.082 517.66 338.76
## - Palmitoylethanolamide 1 24.443 518.02 338.97
## - HDL.C..mM. 1 25.905 519.49 339.79
## - X3.Indolebutyric.acid 1 48.340 541.92 352.18
## - TG..mM. 1 69.611 563.19 363.46
##
## Step: AIC=324.81
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + BASO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Oleoylethanolamide + Palmitic.amide + Palmitoylethanolamide +
## Stearoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Dopa + Sphinganine + Sphinganine.1.phosphate + Sphingosine +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## Phenylacetic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + X4.Hydroxyphenylpropionate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + p.Cresol.glucuronide +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - p.Cresol.glucuronide 1 0.021 493.61 322.82
## - BASO.... 1 0.025 493.62 322.83
## - X4.Hydroxyphenylpropionate 1 0.038 493.63 322.83
## - S.gosine.1.phosphate_b 1 0.039 493.63 322.83
## - Dopa 1 0.059 493.65 322.85
## - WBC..10.9.L. 1 0.067 493.66 322.85
## - X4.Ethylphenyl.sulfate 1 0.071 493.66 322.85
## - Oleoylethanolamide 1 0.081 493.67 322.86
## - UA..uM. 1 0.100 493.69 322.87
## - Υ.GT..U.L. 1 0.104 493.70 322.87
## - Putrescine 1 0.106 493.70 322.87
## - Phenylacetic.acid 1 0.147 493.74 322.90
## - TC..mM. 1 0.150 493.74 322.90
## - Sphingosine 1 0.152 493.74 322.90
## - X4.Hydroxybenzoic.acid 1 0.180 493.77 322.92
## - Palmitic.amide 1 0.223 493.82 322.94
## - Sphingosine.1.phosphate 1 0.228 493.82 322.95
## - p.Cresol.sulfate 1 0.253 493.85 322.96
## - p.Cresol 1 0.317 493.91 323.00
## - CHE..U.L. 1 0.344 493.94 323.01
## - Stearoylethanolamide 1 0.352 493.95 323.02
## - Benzoic.acid 1 0.385 493.98 323.04
## - Indole.3.propionic.acid 1 0.491 494.08 323.10
## - X5.Methoxyindoleacetate 1 0.644 494.24 323.19
## - Spermidine 1 0.777 494.37 323.27
## - X3.Hydroxybenzoic.acid 1 0.783 494.38 323.27
## - Spermine 1 0.784 494.38 323.28
## - X4.Hydroxyphenyllactate 1 0.804 494.40 323.29
## - Salicylic.acid 1 1.026 494.62 323.42
## - Iodide 1 1.050 494.64 323.43
## - Hippuric.acid 1 1.268 494.86 323.56
## - Cre..uM. 1 1.512 495.10 323.71
## - Phenol 1 1.622 495.21 323.77
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.860 495.45 323.91
## - Bilirubin 1 2.009 495.60 324.00
## - Urocanic.acid 1 2.102 495.70 324.06
## - ALB..g.L. 1 2.395 495.99 324.23
## - ALP..U.L. 1 2.474 496.07 324.28
## - N8.Acetylspermidine 1 2.501 496.09 324.29
## - Indole.3.methyl.acetate 1 2.519 496.11 324.30
## - Sphinganine.1.phosphate 1 2.530 496.12 324.31
## - Acetylcholine 1 2.537 496.13 324.31
## - N.Acetylcadaverine 1 3.018 496.61 324.60
## - Bilirubin.1 1 3.217 496.81 324.71
## - TBA..uM. 1 3.319 496.91 324.77
## - Homovanillic.acid.sulfate 1 3.335 496.93 324.78
## <none> 493.59 324.81
## - Phenyllactate 1 4.224 497.82 325.31
## - EO.... 1 4.237 497.83 325.31
## - Cinnamoylglycine 1 4.425 498.02 325.43
## - X2.Hydroxy.Hippuric.Acid 1 4.473 498.07 325.45
## - T.BIL..uM. 1 4.663 498.26 325.57
## - D.BIL..uM. 1 4.859 498.45 325.68
## - Indoxyl.sulfate 1 4.861 498.45 325.68
## - Imidazolepropionic.acid 1 4.937 498.53 325.73
## - Phenylacetylglutamine.PAGln. 1 5.359 498.95 325.97
## - N.acetyl.aspartic.acid 1 5.443 499.04 326.02
## - Phenylethylamine 1 5.870 499.46 326.27
## - Cholesterol.sulfate 1 6.069 499.66 326.39
## + Dopamine 1 0.011 493.58 326.80
## + Urea..mM. 1 0.009 493.58 326.81
## + X3.Hydroxyphenylacetic.acid 1 0.008 493.58 326.81
## + LDL.C..mM. 1 0.005 493.59 326.81
## + Enterolactone 1 0.001 493.59 326.81
## + Biliverdin 1 0.000 493.59 326.81
## - X3.Hydroxyhippuric.acid 1 7.356 500.95 327.15
## - X3.Hydroxyanthranilic.acid 1 7.520 501.11 327.24
## - Xanthurenic.acid 1 7.528 501.12 327.25
## - Kynurenic.acid 1 7.974 501.57 327.51
## - Gamma.aminobutyric.acid 1 8.077 501.67 327.57
## - Octadecanamide 1 8.207 501.80 327.64
## - Oleamide 1 8.237 501.83 327.66
## - Indole.3.carboxaldehyde 1 8.404 502.00 327.76
## - S.ganine.1.phosphate_b 1 9.685 503.28 328.50
## - Ascorbic.acid 1 10.613 504.21 329.04
## - Sphinganine 1 11.079 504.67 329.31
## - LYMPH.... 1 11.726 505.32 329.69
## - NEUT.... 1 11.847 505.44 329.76
## - AST..U.L. 1 13.174 506.77 330.53
## - X5.Aminopentanoic.acid 1 14.165 507.76 331.10
## - Acetylglycine 1 14.754 508.35 331.44
## - Phenyl.sulfate 1 15.985 509.58 332.15
## - Pantothenol 1 17.412 511.00 332.97
## - ALT..U.L. 1 20.822 514.41 334.92
## - X3.Hydroxypropionic.acid 1 21.798 515.39 335.47
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.928 516.52 336.11
## - X1.5.Anhydrosorbitol 1 23.836 517.43 336.63
## - Indole.3.acrylic.acid 1 24.281 517.87 336.88
## - Palmitoylethanolamide 1 24.805 518.40 337.18
## - HDL.C..mM. 1 25.893 519.49 337.79
## - X3.Indolebutyric.acid 1 48.349 541.94 350.19
## - TG..mM. 1 69.601 563.19 361.46
##
## Step: AIC=322.82
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + BASO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Oleoylethanolamide + Palmitic.amide + Palmitoylethanolamide +
## Stearoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Dopa + Sphinganine + Sphinganine.1.phosphate + Sphingosine +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## Phenylacetic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + X4.Hydroxyphenylpropionate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - BASO.... 1 0.026 493.64 320.84
## - X4.Hydroxyphenylpropionate 1 0.038 493.65 320.85
## - S.gosine.1.phosphate_b 1 0.046 493.66 320.85
## - Dopa 1 0.070 493.68 320.86
## - WBC..10.9.L. 1 0.072 493.69 320.87
## - Oleoylethanolamide 1 0.074 493.69 320.87
## - X4.Ethylphenyl.sulfate 1 0.077 493.69 320.87
## - Putrescine 1 0.097 493.71 320.88
## - Υ.GT..U.L. 1 0.097 493.71 320.88
## - UA..uM. 1 0.104 493.72 320.88
## - TC..mM. 1 0.147 493.76 320.91
## - Phenylacetic.acid 1 0.163 493.78 320.92
## - Sphingosine 1 0.175 493.79 320.93
## - X4.Hydroxybenzoic.acid 1 0.181 493.80 320.93
## - Sphingosine.1.phosphate 1 0.232 493.85 320.96
## - Palmitic.amide 1 0.236 493.85 320.96
## - p.Cresol.sulfate 1 0.245 493.86 320.97
## - p.Cresol 1 0.300 493.91 321.00
## - CHE..U.L. 1 0.339 493.95 321.02
## - Stearoylethanolamide 1 0.357 493.97 321.03
## - Benzoic.acid 1 0.373 493.99 321.04
## - Indole.3.propionic.acid 1 0.497 494.11 321.12
## - X5.Methoxyindoleacetate 1 0.649 494.26 321.21
## - Spermidine 1 0.756 494.37 321.27
## - X3.Hydroxybenzoic.acid 1 0.761 494.38 321.27
## - X4.Hydroxyphenyllactate 1 0.787 494.40 321.29
## - Spermine 1 0.790 494.40 321.29
## - Salicylic.acid 1 1.033 494.65 321.44
## - Iodide 1 1.037 494.65 321.44
## - Hippuric.acid 1 1.289 494.90 321.59
## - Cre..uM. 1 1.519 495.13 321.72
## - Phenol 1 1.663 495.28 321.81
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.897 495.51 321.95
## - Bilirubin 1 2.019 495.63 322.02
## - Urocanic.acid 1 2.101 495.72 322.07
## - ALB..g.L. 1 2.378 495.99 322.23
## - ALP..U.L. 1 2.463 496.08 322.28
## - Indole.3.methyl.acetate 1 2.526 496.14 322.32
## - N8.Acetylspermidine 1 2.530 496.14 322.32
## - Acetylcholine 1 2.530 496.14 322.32
## - Sphinganine.1.phosphate 1 2.535 496.15 322.32
## - N.Acetylcadaverine 1 3.125 496.74 322.67
## - Bilirubin.1 1 3.248 496.86 322.74
## - TBA..uM. 1 3.308 496.92 322.78
## - Homovanillic.acid.sulfate 1 3.316 496.93 322.78
## <none> 493.61 322.82
## - Phenyllactate 1 4.205 497.82 323.31
## - EO.... 1 4.235 497.85 323.33
## - Cinnamoylglycine 1 4.415 498.03 323.43
## - X2.Hydroxy.Hippuric.Acid 1 4.518 498.13 323.49
## - T.BIL..uM. 1 4.699 498.31 323.60
## - D.BIL..uM. 1 4.859 498.47 323.69
## - Imidazolepropionic.acid 1 4.933 498.55 323.74
## - Indoxyl.sulfate 1 5.413 499.03 324.02
## - N.acetyl.aspartic.acid 1 5.499 499.11 324.07
## - Phenylethylamine 1 5.850 499.46 324.28
## - Cholesterol.sulfate 1 6.067 499.68 324.40
## - Phenylacetylglutamine.PAGln. 1 6.576 500.19 324.70
## + p.Cresol.glucuronide 1 0.021 493.59 324.81
## + Urea..mM. 1 0.011 493.60 324.82
## + X3.Hydroxyphenylacetic.acid 1 0.011 493.60 324.82
## + Dopamine 1 0.009 493.60 324.82
## + LDL.C..mM. 1 0.005 493.61 324.82
## + Biliverdin 1 0.000 493.61 324.82
## + Enterolactone 1 0.000 493.61 324.82
## - X3.Hydroxyhippuric.acid 1 7.337 500.95 325.15
## - Xanthurenic.acid 1 7.523 501.14 325.26
## - X3.Hydroxyanthranilic.acid 1 7.534 501.15 325.26
## - Kynurenic.acid 1 8.087 501.70 325.58
## - Gamma.aminobutyric.acid 1 8.193 501.81 325.65
## - Octadecanamide 1 8.198 501.81 325.65
## - Oleamide 1 8.232 501.85 325.67
## - Indole.3.carboxaldehyde 1 8.472 502.09 325.81
## - S.ganine.1.phosphate_b 1 9.772 503.39 326.57
## - Ascorbic.acid 1 10.634 504.25 327.07
## - Sphinganine 1 11.333 504.95 327.47
## - LYMPH.... 1 11.724 505.34 327.70
## - NEUT.... 1 11.868 505.48 327.78
## - AST..U.L. 1 13.163 506.78 328.53
## - X5.Aminopentanoic.acid 1 14.302 507.92 329.19
## - Acetylglycine 1 14.899 508.51 329.54
## - Phenyl.sulfate 1 16.339 509.95 330.36
## - Pantothenol 1 17.441 511.06 331.00
## - ALT..U.L. 1 20.862 514.48 332.95
## - X3.Hydroxypropionic.acid 1 22.687 516.30 333.99
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.912 516.53 334.12
## - X1.5.Anhydrosorbitol 1 24.249 517.86 334.87
## - Indole.3.acrylic.acid 1 24.387 518.00 334.95
## - Palmitoylethanolamide 1 25.059 518.67 335.33
## - HDL.C..mM. 1 25.936 519.55 335.83
## - X3.Indolebutyric.acid 1 48.735 542.35 348.41
## - TG..mM. 1 69.608 563.22 359.48
##
## Step: AIC=320.84
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Oleoylethanolamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## X4.Hydroxyphenylpropionate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + S.gosine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - S.gosine.1.phosphate_b 1 0.038 493.68 318.86
## - X4.Hydroxyphenylpropionate 1 0.041 493.68 318.86
## - WBC..10.9.L. 1 0.075 493.72 318.88
## - Dopa 1 0.077 493.72 318.88
## - Oleoylethanolamide 1 0.081 493.72 318.89
## - X4.Ethylphenyl.sulfate 1 0.084 493.72 318.89
## - Putrescine 1 0.099 493.74 318.90
## - Υ.GT..U.L. 1 0.103 493.74 318.90
## - UA..uM. 1 0.110 493.75 318.90
## - TC..mM. 1 0.139 493.78 318.92
## - Sphingosine 1 0.162 493.80 318.94
## - Phenylacetic.acid 1 0.166 493.81 318.94
## - X4.Hydroxybenzoic.acid 1 0.171 493.81 318.94
## - Sphingosine.1.phosphate 1 0.233 493.87 318.98
## - p.Cresol.sulfate 1 0.236 493.88 318.98
## - Palmitic.amide 1 0.259 493.90 318.99
## - p.Cresol 1 0.314 493.95 319.03
## - CHE..U.L. 1 0.338 493.98 319.04
## - Stearoylethanolamide 1 0.357 494.00 319.05
## - Benzoic.acid 1 0.366 494.01 319.06
## - Indole.3.propionic.acid 1 0.501 494.14 319.14
## - X5.Methoxyindoleacetate 1 0.648 494.29 319.22
## - X4.Hydroxyphenyllactate 1 0.763 494.40 319.29
## - Spermidine 1 0.764 494.40 319.29
## - Spermine 1 0.788 494.43 319.31
## - X3.Hydroxybenzoic.acid 1 0.788 494.43 319.31
## - Salicylic.acid 1 1.012 494.65 319.44
## - Iodide 1 1.054 494.69 319.46
## - Hippuric.acid 1 1.301 494.94 319.61
## - Cre..uM. 1 1.512 495.15 319.73
## - Phenol 1 1.639 495.28 319.81
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.916 495.56 319.97
## - Bilirubin 1 2.048 495.69 320.05
## - Urocanic.acid 1 2.079 495.72 320.07
## - ALB..g.L. 1 2.398 496.04 320.26
## - ALP..U.L. 1 2.466 496.11 320.30
## - N8.Acetylspermidine 1 2.518 496.16 320.33
## - Acetylcholine 1 2.525 496.17 320.33
## - Indole.3.methyl.acetate 1 2.533 496.17 320.34
## - Sphinganine.1.phosphate 1 2.579 496.22 320.37
## - N.Acetylcadaverine 1 3.102 496.74 320.67
## - TBA..uM. 1 3.295 496.94 320.79
## - Bilirubin.1 1 3.304 496.94 320.79
## - Homovanillic.acid.sulfate 1 3.332 496.97 320.81
## <none> 493.64 320.84
## - Phenyllactate 1 4.180 497.82 321.31
## - Cinnamoylglycine 1 4.420 498.06 321.45
## - X2.Hydroxy.Hippuric.Acid 1 4.492 498.13 321.49
## - T.BIL..uM. 1 4.727 498.37 321.63
## - EO.... 1 4.787 498.43 321.67
## - D.BIL..uM. 1 4.889 498.53 321.73
## - Imidazolepropionic.acid 1 4.932 498.57 321.75
## - Indoxyl.sulfate 1 5.438 499.08 322.05
## - N.acetyl.aspartic.acid 1 5.473 499.11 322.07
## - Phenylethylamine 1 5.828 499.47 322.28
## - Cholesterol.sulfate 1 6.041 499.68 322.40
## + BASO.... 1 0.026 493.61 322.82
## + p.Cresol.glucuronide 1 0.023 493.62 322.83
## + X3.Hydroxyphenylacetic.acid 1 0.014 493.63 322.83
## + Urea..mM. 1 0.009 493.63 322.83
## + Dopamine 1 0.008 493.63 322.83
## + LDL.C..mM. 1 0.006 493.63 322.84
## + Enterolactone 1 0.000 493.64 322.84
## + Biliverdin 1 0.000 493.64 322.84
## - Phenylacetylglutamine.PAGln. 1 6.793 500.43 322.84
## - X3.Hydroxyhippuric.acid 1 7.381 501.02 323.19
## - X3.Hydroxyanthranilic.acid 1 7.509 501.15 323.26
## - Xanthurenic.acid 1 7.596 501.24 323.31
## - Kynurenic.acid 1 8.164 501.80 323.65
## - Gamma.aminobutyric.acid 1 8.189 501.83 323.66
## - Oleamide 1 8.210 501.85 323.67
## - Octadecanamide 1 8.310 501.95 323.73
## - Indole.3.carboxaldehyde 1 8.457 502.10 323.82
## - S.ganine.1.phosphate_b 1 9.785 503.43 324.59
## - Ascorbic.acid 1 10.667 504.31 325.10
## - Sphinganine 1 11.316 504.96 325.48
## - LYMPH.... 1 11.904 505.54 325.82
## - NEUT.... 1 12.086 505.73 325.93
## - AST..U.L. 1 13.141 506.78 326.54
## - X5.Aminopentanoic.acid 1 14.283 507.92 327.20
## - Acetylglycine 1 15.302 508.94 327.78
## - Phenyl.sulfate 1 16.362 510.00 328.39
## - Pantothenol 1 17.432 511.07 329.01
## - ALT..U.L. 1 20.842 514.48 330.96
## - X3.Hydroxypropionic.acid 1 22.775 516.42 332.05
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.244 516.88 332.32
## - X1.5.Anhydrosorbitol 1 24.256 517.90 332.89
## - Indole.3.acrylic.acid 1 24.498 518.14 333.03
## - Palmitoylethanolamide 1 25.035 518.68 333.33
## - HDL.C..mM. 1 25.935 519.58 333.84
## - X3.Indolebutyric.acid 1 49.643 543.28 346.92
## - TG..mM. 1 69.588 563.23 357.48
##
## Step: AIC=318.86
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Oleoylethanolamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## X4.Hydroxyphenylpropionate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - X4.Hydroxyphenylpropionate 1 0.054 493.73 316.89
## - Dopa 1 0.074 493.75 316.91
## - X4.Ethylphenyl.sulfate 1 0.080 493.76 316.91
## - WBC..10.9.L. 1 0.083 493.76 316.91
## - Oleoylethanolamide 1 0.085 493.76 316.91
## - Υ.GT..U.L. 1 0.094 493.77 316.92
## - UA..uM. 1 0.112 493.79 316.93
## - TC..mM. 1 0.139 493.82 316.94
## - Sphingosine 1 0.149 493.83 316.95
## - Phenylacetic.acid 1 0.154 493.83 316.95
## - Putrescine 1 0.180 493.86 316.97
## - X4.Hydroxybenzoic.acid 1 0.191 493.87 316.97
## - p.Cresol.sulfate 1 0.243 493.92 317.01
## - Palmitic.amide 1 0.247 493.93 317.01
## - p.Cresol 1 0.308 493.99 317.04
## - CHE..U.L. 1 0.341 494.02 317.06
## - Stearoylethanolamide 1 0.341 494.02 317.06
## - Benzoic.acid 1 0.349 494.03 317.07
## - Sphingosine.1.phosphate 1 0.459 494.14 317.13
## - Indole.3.propionic.acid 1 0.489 494.17 317.15
## - X5.Methoxyindoleacetate 1 0.652 494.33 317.25
## - Spermidine 1 0.738 494.42 317.30
## - X4.Hydroxyphenyllactate 1 0.760 494.44 317.31
## - X3.Hydroxybenzoic.acid 1 0.798 494.48 317.33
## - Spermine 1 0.803 494.48 317.34
## - Iodide 1 1.061 494.74 317.49
## - Salicylic.acid 1 1.073 494.75 317.50
## - Hippuric.acid 1 1.315 494.99 317.64
## - Cre..uM. 1 1.473 495.15 317.73
## - Phenol 1 1.647 495.33 317.84
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.893 495.57 317.98
## - Urocanic.acid 1 2.098 495.78 318.10
## - Bilirubin 1 2.314 495.99 318.23
## - ALB..g.L. 1 2.392 496.07 318.28
## - ALP..U.L. 1 2.448 496.13 318.31
## - Indole.3.methyl.acetate 1 2.515 496.19 318.35
## - N8.Acetylspermidine 1 2.551 496.23 318.37
## - Acetylcholine 1 2.602 496.28 318.40
## - Sphinganine.1.phosphate 1 2.913 496.59 318.59
## - N.Acetylcadaverine 1 3.138 496.82 318.72
## - Homovanillic.acid.sulfate 1 3.304 496.98 318.82
## - TBA..uM. 1 3.332 497.01 318.83
## <none> 493.68 318.86
## - Bilirubin.1 1 3.424 497.10 318.89
## - Phenyllactate 1 4.148 497.83 319.31
## - X2.Hydroxy.Hippuric.Acid 1 4.594 498.27 319.58
## - Cinnamoylglycine 1 4.682 498.36 319.63
## - T.BIL..uM. 1 4.690 498.37 319.63
## - EO.... 1 4.825 498.50 319.71
## - D.BIL..uM. 1 4.871 498.55 319.74
## - Imidazolepropionic.acid 1 4.904 498.58 319.76
## - N.acetyl.aspartic.acid 1 5.453 499.13 320.08
## - Indoxyl.sulfate 1 5.566 499.24 320.15
## - Phenylethylamine 1 6.059 499.74 320.44
## - Cholesterol.sulfate 1 6.070 499.75 320.44
## + S.gosine.1.phosphate_b 1 0.038 493.64 320.84
## + p.Cresol.glucuronide 1 0.029 493.65 320.84
## + BASO.... 1 0.019 493.66 320.85
## + Dopamine 1 0.016 493.66 320.85
## + X3.Hydroxyphenylacetic.acid 1 0.014 493.67 320.85
## + Urea..mM. 1 0.010 493.67 320.86
## + LDL.C..mM. 1 0.007 493.67 320.86
## + Enterolactone 1 0.000 493.68 320.86
## + Biliverdin 1 0.000 493.68 320.86
## - Phenylacetylglutamine.PAGln. 1 6.844 500.52 320.90
## - X3.Hydroxyhippuric.acid 1 7.391 501.07 321.22
## - X3.Hydroxyanthranilic.acid 1 7.695 501.37 321.39
## - Xanthurenic.acid 1 7.762 501.44 321.43
## - Gamma.aminobutyric.acid 1 8.295 501.97 321.74
## - Kynurenic.acid 1 8.348 502.03 321.78
## - Oleamide 1 8.484 502.16 321.85
## - Octadecanamide 1 8.732 502.41 322.00
## - Indole.3.carboxaldehyde 1 8.837 502.52 322.06
## - S.ganine.1.phosphate_b 1 9.867 503.55 322.66
## - Ascorbic.acid 1 10.938 504.62 323.28
## - Sphinganine 1 11.335 505.01 323.51
## - LYMPH.... 1 12.037 505.72 323.92
## - NEUT.... 1 12.178 505.86 324.00
## - AST..U.L. 1 13.289 506.97 324.64
## - X5.Aminopentanoic.acid 1 14.252 507.93 325.20
## - Acetylglycine 1 15.919 509.60 326.16
## - Phenyl.sulfate 1 16.514 510.19 326.50
## - Pantothenol 1 17.571 511.25 327.11
## - ALT..U.L. 1 20.937 514.62 329.03
## - X3.Hydroxypropionic.acid 1 22.839 516.52 330.11
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.213 516.89 330.32
## - X1.5.Anhydrosorbitol 1 24.959 518.64 331.31
## - Palmitoylethanolamide 1 25.116 518.79 331.40
## - Indole.3.acrylic.acid 1 25.674 519.35 331.72
## - HDL.C..mM. 1 26.319 520.00 332.08
## - X3.Indolebutyric.acid 1 53.261 546.94 346.88
## - TG..mM. 1 69.991 563.67 355.71
##
## Step: AIC=316.89
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + WBC..10.9.L. +
## NEUT.... + LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Oleoylethanolamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - WBC..10.9.L. 1 0.084 493.82 314.94
## - X4.Ethylphenyl.sulfate 1 0.086 493.82 314.94
## - UA..uM. 1 0.099 493.83 314.95
## - Υ.GT..U.L. 1 0.101 493.83 314.95
## - Oleoylethanolamide 1 0.102 493.84 314.95
## - Dopa 1 0.106 493.84 314.96
## - Sphingosine 1 0.125 493.86 314.97
## - TC..mM. 1 0.134 493.87 314.97
## - Phenylacetic.acid 1 0.154 493.89 314.99
## - Putrescine 1 0.163 493.90 314.99
## - X4.Hydroxybenzoic.acid 1 0.181 493.91 315.00
## - p.Cresol.sulfate 1 0.215 493.95 315.02
## - Palmitic.amide 1 0.264 494.00 315.05
## - Stearoylethanolamide 1 0.326 494.06 315.09
## - p.Cresol 1 0.341 494.07 315.10
## - CHE..U.L. 1 0.341 494.07 315.10
## - Benzoic.acid 1 0.342 494.07 315.10
## - Sphingosine.1.phosphate 1 0.450 494.18 315.16
## - Indole.3.propionic.acid 1 0.621 494.35 315.26
## - X5.Methoxyindoleacetate 1 0.655 494.39 315.28
## - Spermidine 1 0.751 494.48 315.34
## - X3.Hydroxybenzoic.acid 1 0.771 494.50 315.35
## - X4.Hydroxyphenyllactate 1 0.787 494.52 315.36
## - Spermine 1 0.789 494.52 315.36
## - Salicylic.acid 1 1.049 494.78 315.52
## - Iodide 1 1.085 494.82 315.54
## - Cre..uM. 1 1.440 495.17 315.75
## - Hippuric.acid 1 1.497 495.23 315.78
## - Phenol 1 1.607 495.34 315.85
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.974 495.71 316.06
## - Urocanic.acid 1 2.110 495.84 316.14
## - Bilirubin 1 2.339 496.07 316.28
## - ALB..g.L. 1 2.370 496.10 316.30
## - ALP..U.L. 1 2.452 496.18 316.35
## - Acetylcholine 1 2.557 496.29 316.41
## - N8.Acetylspermidine 1 2.567 496.30 316.41
## - Indole.3.methyl.acetate 1 2.828 496.56 316.57
## - Sphinganine.1.phosphate 1 2.894 496.63 316.61
## - N.Acetylcadaverine 1 3.084 496.82 316.72
## - Homovanillic.acid.sulfate 1 3.289 497.02 316.84
## <none> 493.73 316.89
## - TBA..uM. 1 3.429 497.16 316.92
## - Bilirubin.1 1 3.510 497.24 316.97
## - Phenyllactate 1 4.151 497.88 317.35
## - X2.Hydroxy.Hippuric.Acid 1 4.558 498.29 317.59
## - T.BIL..uM. 1 4.685 498.42 317.66
## - Cinnamoylglycine 1 4.713 498.45 317.68
## - D.BIL..uM. 1 4.843 498.58 317.75
## - EO.... 1 4.902 498.63 317.79
## - Imidazolepropionic.acid 1 4.942 498.68 317.81
## - N.acetyl.aspartic.acid 1 5.402 499.13 318.08
## - Indoxyl.sulfate 1 5.514 499.25 318.15
## - Phenylethylamine 1 6.005 499.74 318.44
## - Cholesterol.sulfate 1 6.034 499.77 318.45
## + X4.Hydroxyphenylpropionate 1 0.054 493.68 318.86
## + S.gosine.1.phosphate_b 1 0.052 493.68 318.86
## + p.Cresol.glucuronide 1 0.030 493.70 318.88
## + BASO.... 1 0.021 493.71 318.88
## + Dopamine 1 0.016 493.72 318.88
## + X3.Hydroxyphenylacetic.acid 1 0.010 493.72 318.89
## + LDL.C..mM. 1 0.010 493.72 318.89
## + Urea..mM. 1 0.008 493.73 318.89
## + Biliverdin 1 0.001 493.73 318.89
## + Enterolactone 1 0.000 493.73 318.89
## - Phenylacetylglutamine.PAGln. 1 6.791 500.52 318.90
## - X3.Hydroxyhippuric.acid 1 7.567 501.30 319.35
## - X3.Hydroxyanthranilic.acid 1 7.704 501.44 319.43
## - Xanthurenic.acid 1 7.886 501.62 319.54
## - Gamma.aminobutyric.acid 1 8.246 501.98 319.75
## - Kynurenic.acid 1 8.304 502.04 319.78
## - Oleamide 1 8.454 502.19 319.87
## - Octadecanamide 1 8.689 502.42 320.01
## - Indole.3.carboxaldehyde 1 8.794 502.53 320.07
## - S.ganine.1.phosphate_b 1 9.841 503.57 320.68
## - Ascorbic.acid 1 11.011 504.74 321.36
## - Sphinganine 1 11.298 505.03 321.52
## - LYMPH.... 1 12.021 505.75 321.94
## - NEUT.... 1 12.203 505.94 322.05
## - AST..U.L. 1 13.337 507.07 322.70
## - X5.Aminopentanoic.acid 1 14.211 507.94 323.21
## - Acetylglycine 1 16.409 510.14 324.47
## - Phenyl.sulfate 1 16.479 510.21 324.51
## - Pantothenol 1 17.638 511.37 325.18
## - ALT..U.L. 1 20.901 514.63 327.04
## - X3.Hydroxypropionic.acid 1 23.346 517.08 328.43
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.535 517.27 328.54
## - Palmitoylethanolamide 1 25.067 518.80 329.40
## - X1.5.Anhydrosorbitol 1 25.198 518.93 329.48
## - HDL.C..mM. 1 26.306 520.04 330.10
## - Indole.3.acrylic.acid 1 38.184 531.92 336.72
## - X3.Indolebutyric.acid 1 53.988 547.72 345.30
## - TG..mM. 1 69.940 563.67 353.71
##
## Step: AIC=314.94
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Oleoylethanolamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Ethylphenyl.sulfate +
## X4.Hydroxybenzoic.acid.4.O.sulphate + X3.Hydroxypropionic.acid +
## Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - X4.Ethylphenyl.sulfate 1 0.061 493.88 312.98
## - UA..uM. 1 0.085 493.90 312.99
## - Υ.GT..U.L. 1 0.099 493.92 313.00
## - Oleoylethanolamide 1 0.100 493.92 313.00
## - Dopa 1 0.108 493.93 313.01
## - Sphingosine 1 0.118 493.93 313.01
## - TC..mM. 1 0.139 493.96 313.03
## - Putrescine 1 0.142 493.96 313.03
## - Phenylacetic.acid 1 0.148 493.96 313.03
## - X4.Hydroxybenzoic.acid 1 0.206 494.02 313.07
## - p.Cresol.sulfate 1 0.255 494.07 313.10
## - Palmitic.amide 1 0.271 494.09 313.10
## - Stearoylethanolamide 1 0.296 494.11 313.12
## - p.Cresol 1 0.320 494.14 313.13
## - Benzoic.acid 1 0.323 494.14 313.14
## - CHE..U.L. 1 0.371 494.19 313.16
## - Sphingosine.1.phosphate 1 0.498 494.31 313.24
## - Indole.3.propionic.acid 1 0.646 494.46 313.33
## - X5.Methoxyindoleacetate 1 0.649 494.47 313.33
## - Spermine 1 0.729 494.55 313.38
## - Spermidine 1 0.756 494.57 313.39
## - X3.Hydroxybenzoic.acid 1 0.767 494.58 313.40
## - X4.Hydroxyphenyllactate 1 0.797 494.61 313.42
## - Iodide 1 1.078 494.89 313.58
## - Salicylic.acid 1 1.116 494.93 313.60
## - Cre..uM. 1 1.373 495.19 313.76
## - Hippuric.acid 1 1.471 495.29 313.82
## - Phenol 1 1.703 495.52 313.95
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.058 495.87 314.16
## - Urocanic.acid 1 2.102 495.92 314.19
## - ALB..g.L. 1 2.346 496.16 314.33
## - Bilirubin 1 2.387 496.20 314.36
## - Acetylcholine 1 2.485 496.30 314.41
## - ALP..U.L. 1 2.536 496.35 314.44
## - N8.Acetylspermidine 1 2.633 496.45 314.50
## - Indole.3.methyl.acetate 1 2.849 496.67 314.63
## - Sphinganine.1.phosphate 1 2.910 496.73 314.66
## - N.Acetylcadaverine 1 3.028 496.84 314.73
## - Homovanillic.acid.sulfate 1 3.292 497.11 314.89
## - TBA..uM. 1 3.346 497.16 314.92
## <none> 493.82 314.94
## - Bilirubin.1 1 3.548 497.36 315.04
## - Phenyllactate 1 4.225 498.04 315.44
## - X2.Hydroxy.Hippuric.Acid 1 4.641 498.46 315.68
## - Cinnamoylglycine 1 4.649 498.47 315.69
## - EO.... 1 4.820 498.64 315.79
## - Imidazolepropionic.acid 1 4.872 498.69 315.82
## - T.BIL..uM. 1 4.956 498.77 315.87
## - D.BIL..uM. 1 5.112 498.93 315.96
## - N.acetyl.aspartic.acid 1 5.332 499.15 316.09
## - Indoxyl.sulfate 1 5.431 499.25 316.15
## - Cholesterol.sulfate 1 5.952 499.77 316.45
## - Phenylethylamine 1 6.173 499.99 316.58
## + WBC..10.9.L. 1 0.084 493.73 316.89
## + S.gosine.1.phosphate_b 1 0.060 493.76 316.91
## + X4.Hydroxyphenylpropionate 1 0.055 493.76 316.91
## + p.Cresol.glucuronide 1 0.036 493.78 316.92
## + BASO.... 1 0.024 493.79 316.93
## + X3.Hydroxyphenylacetic.acid 1 0.018 493.80 316.93
## + Dopamine 1 0.011 493.81 316.94
## + LDL.C..mM. 1 0.010 493.81 316.94
## + Urea..mM. 1 0.006 493.81 316.94
## + Biliverdin 1 0.004 493.81 316.94
## + Enterolactone 1 0.000 493.82 316.94
## - Phenylacetylglutamine.PAGln. 1 6.940 500.76 317.03
## - X3.Hydroxyanthranilic.acid 1 7.868 501.68 317.58
## - X3.Hydroxyhippuric.acid 1 8.118 501.93 317.72
## - Gamma.aminobutyric.acid 1 8.164 501.98 317.75
## - Xanthurenic.acid 1 8.220 502.04 317.78
## - Oleamide 1 8.370 502.19 317.87
## - Kynurenic.acid 1 8.598 502.41 318.00
## - Octadecanamide 1 8.614 502.43 318.01
## - Indole.3.carboxaldehyde 1 8.733 502.55 318.08
## - S.ganine.1.phosphate_b 1 10.167 503.98 318.91
## - Ascorbic.acid 1 10.989 504.81 319.39
## - Sphinganine 1 11.261 505.08 319.55
## - LYMPH.... 1 11.960 505.78 319.96
## - NEUT.... 1 12.230 506.05 320.11
## - AST..U.L. 1 13.855 507.67 321.05
## - X5.Aminopentanoic.acid 1 14.207 508.02 321.25
## - Acetylglycine 1 16.414 510.23 322.52
## - Phenyl.sulfate 1 16.527 510.34 322.59
## - Pantothenol 1 17.566 511.38 323.18
## - ALT..U.L. 1 21.756 515.57 325.58
## - X3.Hydroxypropionic.acid 1 23.290 517.11 326.45
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.279 518.10 327.01
## - Palmitoylethanolamide 1 25.098 518.91 327.47
## - X1.5.Anhydrosorbitol 1 25.186 519.00 327.52
## - HDL.C..mM. 1 26.296 520.11 328.14
## - Indole.3.acrylic.acid 1 38.633 532.45 335.01
## - X3.Indolebutyric.acid 1 53.915 547.73 343.30
## - TG..mM. 1 71.070 564.89 352.34
##
## Step: AIC=312.98
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Oleoylethanolamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Oleoylethanolamide 1 0.071 493.95 311.02
## - UA..uM. 1 0.080 493.96 311.03
## - Υ.GT..U.L. 1 0.097 493.97 311.04
## - Dopa 1 0.114 493.99 311.05
## - Sphingosine 1 0.130 494.01 311.06
## - Phenylacetic.acid 1 0.148 494.03 311.07
## - TC..mM. 1 0.148 494.03 311.07
## - Putrescine 1 0.152 494.03 311.07
## - X4.Hydroxybenzoic.acid 1 0.225 494.10 311.11
## - Palmitic.amide 1 0.266 494.14 311.14
## - Benzoic.acid 1 0.286 494.16 311.15
## - p.Cresol 1 0.286 494.16 311.15
## - p.Cresol.sulfate 1 0.305 494.18 311.16
## - Stearoylethanolamide 1 0.339 494.22 311.18
## - CHE..U.L. 1 0.368 494.25 311.20
## - Sphingosine.1.phosphate 1 0.524 494.40 311.29
## - Indole.3.propionic.acid 1 0.645 494.52 311.36
## - X5.Methoxyindoleacetate 1 0.705 494.58 311.40
## - Spermine 1 0.744 494.62 311.42
## - Spermidine 1 0.765 494.64 311.43
## - X3.Hydroxybenzoic.acid 1 0.790 494.67 311.45
## - X4.Hydroxyphenyllactate 1 0.868 494.75 311.49
## - Iodide 1 1.024 494.90 311.59
## - Salicylic.acid 1 1.164 495.04 311.67
## - Cre..uM. 1 1.396 495.27 311.81
## - Hippuric.acid 1 1.503 495.38 311.87
## - Phenol 1 1.684 495.56 311.98
## - Urocanic.acid 1 2.056 495.93 312.20
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.121 496.00 312.24
## - ALB..g.L. 1 2.287 496.17 312.33
## - Bilirubin 1 2.348 496.23 312.37
## - Acetylcholine 1 2.510 496.39 312.47
## - ALP..U.L. 1 2.637 496.51 312.54
## - N8.Acetylspermidine 1 2.659 496.54 312.55
## - Indole.3.methyl.acetate 1 2.856 496.73 312.67
## - Sphinganine.1.phosphate 1 2.878 496.76 312.68
## - N.Acetylcadaverine 1 3.020 496.90 312.77
## - TBA..uM. 1 3.285 497.16 312.92
## <none> 493.88 312.98
## - Homovanillic.acid.sulfate 1 3.427 497.30 313.01
## - Bilirubin.1 1 3.540 497.42 313.07
## - Phenyllactate 1 4.545 498.42 313.66
## - Cinnamoylglycine 1 4.596 498.47 313.69
## - X2.Hydroxy.Hippuric.Acid 1 4.692 498.57 313.75
## - EO.... 1 4.809 498.69 313.82
## - Imidazolepropionic.acid 1 4.811 498.69 313.82
## - T.BIL..uM. 1 4.919 498.80 313.88
## - D.BIL..uM. 1 5.065 498.94 313.97
## - N.acetyl.aspartic.acid 1 5.271 499.15 314.09
## - Indoxyl.sulfate 1 5.415 499.29 314.17
## - Cholesterol.sulfate 1 5.899 499.78 314.46
## - Phenylethylamine 1 6.162 500.04 314.61
## + X4.Ethylphenyl.sulfate 1 0.061 493.82 314.94
## + X4.Hydroxyphenylpropionate 1 0.060 493.82 314.94
## + WBC..10.9.L. 1 0.059 493.82 314.94
## + S.gosine.1.phosphate_b 1 0.056 493.82 314.95
## + p.Cresol.glucuronide 1 0.042 493.84 314.95
## + BASO.... 1 0.030 493.85 314.96
## + X3.Hydroxyphenylacetic.acid 1 0.029 493.85 314.96
## + Dopamine 1 0.017 493.86 314.97
## + LDL.C..mM. 1 0.014 493.86 314.97
## + Urea..mM. 1 0.006 493.87 314.98
## + Biliverdin 1 0.004 493.87 314.98
## + Enterolactone 1 0.000 493.88 314.98
## - Phenylacetylglutamine.PAGln. 1 6.881 500.76 315.03
## - X3.Hydroxyanthranilic.acid 1 7.832 501.71 315.59
## - X3.Hydroxyhippuric.acid 1 8.117 501.99 315.76
## - Gamma.aminobutyric.acid 1 8.137 502.01 315.77
## - Xanthurenic.acid 1 8.178 502.06 315.79
## - Octadecanamide 1 8.562 502.44 316.02
## - Indole.3.carboxaldehyde 1 8.703 502.58 316.10
## - Oleamide 1 8.715 502.59 316.10
## - Kynurenic.acid 1 8.906 502.78 316.22
## - S.ganine.1.phosphate_b 1 10.174 504.05 316.95
## - Ascorbic.acid 1 10.942 504.82 317.40
## - Sphinganine 1 11.267 505.14 317.59
## - LYMPH.... 1 11.930 505.81 317.97
## - NEUT.... 1 12.216 506.09 318.14
## - X5.Aminopentanoic.acid 1 14.224 508.10 319.30
## - AST..U.L. 1 14.302 508.18 319.34
## - Acetylglycine 1 16.410 510.29 320.56
## - Phenyl.sulfate 1 16.739 510.62 320.75
## - Pantothenol 1 17.525 511.40 321.20
## - ALT..U.L. 1 22.462 516.34 324.01
## - X3.Hydroxypropionic.acid 1 23.232 517.11 324.45
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.290 518.17 325.05
## - X1.5.Anhydrosorbitol 1 25.955 519.83 325.99
## - Palmitoylethanolamide 1 26.027 519.90 326.03
## - HDL.C..mM. 1 27.636 521.51 326.93
## - Indole.3.acrylic.acid 1 38.949 532.83 333.22
## - X3.Indolebutyric.acid 1 54.188 548.07 341.48
## - TG..mM. 1 72.903 566.78 351.32
##
## Step: AIC=311.02
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + UA..uM. + ALB..g.L. +
## TC..mM. + TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + CHE..U.L. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitic.amide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - UA..uM. 1 0.093 494.04 309.08
## - Dopa 1 0.097 494.05 309.08
## - Υ.GT..U.L. 1 0.100 494.05 309.08
## - Sphingosine 1 0.147 494.10 309.11
## - Phenylacetic.acid 1 0.155 494.10 309.11
## - TC..mM. 1 0.172 494.12 309.12
## - Putrescine 1 0.182 494.13 309.13
## - X4.Hydroxybenzoic.acid 1 0.219 494.17 309.15
## - Benzoic.acid 1 0.260 494.21 309.18
## - p.Cresol 1 0.261 494.21 309.18
## - Palmitic.amide 1 0.272 494.22 309.18
## - p.Cresol.sulfate 1 0.331 494.28 309.22
## - CHE..U.L. 1 0.353 494.30 309.23
## - Stearoylethanolamide 1 0.449 494.40 309.29
## - Sphingosine.1.phosphate 1 0.559 494.51 309.35
## - Indole.3.propionic.acid 1 0.643 494.59 309.40
## - Spermine 1 0.767 494.72 309.48
## - Spermidine 1 0.777 494.73 309.48
## - X3.Hydroxybenzoic.acid 1 0.850 494.80 309.53
## - X4.Hydroxyphenyllactate 1 0.856 494.80 309.53
## - X5.Methoxyindoleacetate 1 0.890 494.84 309.55
## - Iodide 1 0.974 494.92 309.60
## - Salicylic.acid 1 1.157 495.11 309.71
## - Hippuric.acid 1 1.479 495.43 309.90
## - Cre..uM. 1 1.504 495.45 309.91
## - Phenol 1 1.671 495.62 310.01
## - Urocanic.acid 1 2.046 495.99 310.23
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.142 496.09 310.29
## - ALB..g.L. 1 2.244 496.19 310.35
## - Bilirubin 1 2.325 496.27 310.40
## - Acetylcholine 1 2.503 496.45 310.50
## - N8.Acetylspermidine 1 2.663 496.61 310.60
## - ALP..U.L. 1 2.670 496.62 310.60
## - Sphinganine.1.phosphate 1 2.841 496.79 310.70
## - Indole.3.methyl.acetate 1 2.845 496.79 310.70
## - N.Acetylcadaverine 1 2.979 496.93 310.78
## - TBA..uM. 1 3.222 497.17 310.93
## <none> 493.95 311.02
## - Homovanillic.acid.sulfate 1 3.395 497.34 311.03
## - Bilirubin.1 1 3.473 497.42 311.07
## - Cinnamoylglycine 1 4.529 498.48 311.70
## - Phenyllactate 1 4.557 498.51 311.71
## - X2.Hydroxy.Hippuric.Acid 1 4.733 498.68 311.82
## - EO.... 1 4.759 498.71 311.83
## - Imidazolepropionic.acid 1 4.796 498.74 311.85
## - T.BIL..uM. 1 4.855 498.80 311.89
## - D.BIL..uM. 1 5.009 498.96 311.98
## - N.acetyl.aspartic.acid 1 5.309 499.26 312.15
## - Indoxyl.sulfate 1 5.347 499.30 312.18
## - Cholesterol.sulfate 1 6.011 499.96 312.57
## - Phenylethylamine 1 6.172 500.12 312.66
## + X4.Hydroxyphenylpropionate 1 0.073 493.87 312.98
## + Oleoylethanolamide 1 0.071 493.88 312.98
## + S.gosine.1.phosphate_b 1 0.063 493.89 312.98
## + WBC..10.9.L. 1 0.062 493.89 312.98
## + BASO.... 1 0.036 493.91 313.00
## + X4.Ethylphenyl.sulfate 1 0.032 493.92 313.00
## + p.Cresol.glucuronide 1 0.031 493.92 313.00
## + X3.Hydroxyphenylacetic.acid 1 0.023 493.92 313.01
## + LDL.C..mM. 1 0.019 493.93 313.01
## + Dopamine 1 0.010 493.94 313.02
## + Urea..mM. 1 0.003 493.95 313.02
## + Biliverdin 1 0.000 493.95 313.02
## + Enterolactone 1 0.000 493.95 313.02
## - Phenylacetylglutamine.PAGln. 1 6.833 500.78 313.05
## - X3.Hydroxyanthranilic.acid 1 7.894 501.84 313.67
## - Gamma.aminobutyric.acid 1 8.084 502.03 313.78
## - Xanthurenic.acid 1 8.193 502.14 313.84
## - X3.Hydroxyhippuric.acid 1 8.203 502.15 313.85
## - Octadecanamide 1 8.499 502.45 314.02
## - Oleamide 1 8.707 502.66 314.14
## - Kynurenic.acid 1 8.874 502.82 314.24
## - Indole.3.carboxaldehyde 1 9.105 503.05 314.37
## - S.ganine.1.phosphate_b 1 10.237 504.19 315.03
## - Ascorbic.acid 1 11.077 505.02 315.52
## - Sphinganine 1 11.281 505.23 315.64
## - LYMPH.... 1 11.865 505.81 315.98
## - NEUT.... 1 12.161 506.11 316.15
## - X5.Aminopentanoic.acid 1 14.277 508.23 317.37
## - AST..U.L. 1 14.462 508.41 317.48
## - Acetylglycine 1 16.499 510.45 318.65
## - Phenyl.sulfate 1 16.693 510.64 318.76
## - Pantothenol 1 17.693 511.64 319.33
## - ALT..U.L. 1 23.056 517.00 322.39
## - X3.Hydroxypropionic.acid 1 23.177 517.13 322.46
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.310 518.26 323.10
## - X1.5.Anhydrosorbitol 1 26.194 520.14 324.16
## - HDL.C..mM. 1 27.880 521.83 325.11
## - Indole.3.acrylic.acid 1 38.889 532.84 331.23
## - Palmitoylethanolamide 1 40.010 533.96 331.84
## - X3.Indolebutyric.acid 1 54.216 548.16 339.54
## - TG..mM. 1 73.429 567.38 349.63
##
## Step: AIC=309.08
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TC..mM. +
## TG..mM. + HDL.C..mM. + ALP..U.L. + Υ.GT..U.L. + T.BIL..uM. +
## D.BIL..uM. + TBA..uM. + CHE..U.L. + NEUT.... + LYMPH.... +
## EO.... + Phenylethylamine + Octadecanamide + Urocanic.acid +
## Imidazolepropionic.acid + Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid +
## Oleamide + Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Υ.GT..U.L. 1 0.100 494.14 307.14
## - Dopa 1 0.108 494.15 307.14
## - TC..mM. 1 0.151 494.19 307.17
## - Phenylacetic.acid 1 0.157 494.20 307.17
## - Sphingosine 1 0.166 494.21 307.18
## - Putrescine 1 0.190 494.23 307.19
## - X4.Hydroxybenzoic.acid 1 0.217 494.26 307.21
## - Palmitic.amide 1 0.255 494.30 307.23
## - p.Cresol 1 0.280 494.32 307.24
## - Benzoic.acid 1 0.300 494.34 307.25
## - p.Cresol.sulfate 1 0.306 494.35 307.26
## - CHE..U.L. 1 0.382 494.42 307.30
## - Stearoylethanolamide 1 0.451 494.49 307.34
## - Sphingosine.1.phosphate 1 0.603 494.64 307.43
## - Indole.3.propionic.acid 1 0.672 494.71 307.48
## - Spermidine 1 0.746 494.79 307.52
## - Spermine 1 0.775 494.82 307.54
## - X4.Hydroxyphenyllactate 1 0.820 494.86 307.56
## - X3.Hydroxybenzoic.acid 1 0.844 494.89 307.58
## - X5.Methoxyindoleacetate 1 0.866 494.91 307.59
## - Iodide 1 0.939 494.98 307.63
## - Salicylic.acid 1 1.148 495.19 307.76
## - Cre..uM. 1 1.419 495.46 307.92
## - Hippuric.acid 1 1.538 495.58 307.99
## - Phenol 1 1.695 495.74 308.08
## - Urocanic.acid 1 2.128 496.17 308.34
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.220 496.26 308.39
## - ALB..g.L. 1 2.247 496.29 308.41
## - Bilirubin 1 2.429 496.47 308.51
## - Acetylcholine 1 2.466 496.51 308.54
## - ALP..U.L. 1 2.634 496.68 308.63
## - Sphinganine.1.phosphate 1 2.749 496.79 308.70
## - N8.Acetylspermidine 1 2.750 496.79 308.70
## - N.Acetylcadaverine 1 2.890 496.93 308.79
## - Indole.3.methyl.acetate 1 2.915 496.96 308.80
## - TBA..uM. 1 3.247 497.29 309.00
## - Homovanillic.acid.sulfate 1 3.359 497.40 309.06
## <none> 494.04 309.08
## - Bilirubin.1 1 3.569 497.61 309.19
## - Cinnamoylglycine 1 4.494 498.54 309.73
## - Phenyllactate 1 4.657 498.70 309.83
## - X2.Hydroxy.Hippuric.Acid 1 4.687 498.73 309.84
## - EO.... 1 4.693 498.73 309.85
## - Imidazolepropionic.acid 1 4.915 498.96 309.98
## - T.BIL..uM. 1 5.171 499.21 310.13
## - Indoxyl.sulfate 1 5.254 499.30 310.18
## - N.acetyl.aspartic.acid 1 5.259 499.30 310.18
## - D.BIL..uM. 1 5.330 499.37 310.22
## - Cholesterol.sulfate 1 5.956 500.00 310.59
## - Phenylethylamine 1 6.204 500.25 310.73
## + UA..uM. 1 0.093 493.95 311.02
## + Oleoylethanolamide 1 0.083 493.96 311.03
## + S.gosine.1.phosphate_b 1 0.062 493.98 311.04
## + X4.Hydroxyphenylpropionate 1 0.059 493.98 311.04
## + WBC..10.9.L. 1 0.052 493.99 311.05
## + BASO.... 1 0.042 494.00 311.05
## + p.Cresol.glucuronide 1 0.033 494.01 311.06
## + X3.Hydroxyphenylacetic.acid 1 0.029 494.01 311.06
## + X4.Ethylphenyl.sulfate 1 0.026 494.01 311.06
## - Phenylacetylglutamine.PAGln. 1 6.765 500.81 311.06
## + LDL.C..mM. 1 0.016 494.02 311.07
## + Dopamine 1 0.006 494.04 311.07
## + Urea..mM. 1 0.004 494.04 311.07
## + Biliverdin 1 0.000 494.04 311.08
## + Enterolactone 1 0.000 494.04 311.08
## - X3.Hydroxyanthranilic.acid 1 7.889 501.93 311.72
## - Xanthurenic.acid 1 8.159 502.20 311.88
## - Gamma.aminobutyric.acid 1 8.174 502.21 311.88
## - Octadecanamide 1 8.518 502.56 312.09
## - X3.Hydroxyhippuric.acid 1 8.569 502.61 312.12
## - Oleamide 1 8.614 502.66 312.14
## - Kynurenic.acid 1 8.805 502.85 312.25
## - Indole.3.carboxaldehyde 1 9.018 503.06 312.38
## - S.ganine.1.phosphate_b 1 10.144 504.19 313.03
## - Ascorbic.acid 1 11.067 505.11 313.57
## - Sphinganine 1 11.444 505.49 313.79
## - LYMPH.... 1 11.854 505.89 314.02
## - NEUT.... 1 12.157 506.20 314.20
## - X5.Aminopentanoic.acid 1 14.732 508.77 315.69
## - AST..U.L. 1 14.784 508.83 315.72
## - Acetylglycine 1 16.522 510.56 316.72
## - Phenyl.sulfate 1 16.601 510.64 316.76
## - Pantothenol 1 17.744 511.79 317.42
## - X3.Hydroxypropionic.acid 1 23.086 517.13 320.46
## - ALT..U.L. 1 24.242 518.28 321.11
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.593 518.63 321.31
## - X1.5.Anhydrosorbitol 1 26.286 520.33 322.27
## - HDL.C..mM. 1 27.798 521.84 323.12
## - Indole.3.acrylic.acid 1 38.839 532.88 329.25
## - Palmitoylethanolamide 1 40.171 534.21 329.98
## - X3.Indolebutyric.acid 1 54.765 548.81 337.88
## - TG..mM. 1 80.108 574.15 351.11
##
## Step: AIC=307.14
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TC..mM. +
## TG..mM. + HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. +
## TBA..uM. + CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Dopa + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Dopa 1 0.142 494.28 305.22
## - TC..mM. 1 0.153 494.29 305.23
## - Phenylacetic.acid 1 0.154 494.29 305.23
## - Sphingosine 1 0.164 494.30 305.23
## - Putrescine 1 0.203 494.34 305.26
## - X4.Hydroxybenzoic.acid 1 0.203 494.34 305.26
## - Benzoic.acid 1 0.275 494.42 305.30
## - p.Cresol.sulfate 1 0.291 494.43 305.31
## - Palmitic.amide 1 0.299 494.44 305.31
## - p.Cresol 1 0.303 494.44 305.32
## - CHE..U.L. 1 0.344 494.49 305.34
## - Stearoylethanolamide 1 0.452 494.59 305.40
## - Sphingosine.1.phosphate 1 0.607 494.75 305.50
## - Indole.3.propionic.acid 1 0.613 494.75 305.50
## - Spermidine 1 0.698 494.84 305.55
## - Spermine 1 0.776 494.92 305.60
## - X4.Hydroxyphenyllactate 1 0.832 494.97 305.63
## - X5.Methoxyindoleacetate 1 0.843 494.98 305.64
## - X3.Hydroxybenzoic.acid 1 0.891 495.03 305.66
## - Iodide 1 0.961 495.10 305.71
## - Salicylic.acid 1 1.109 495.25 305.79
## - Cre..uM. 1 1.374 495.51 305.95
## - Hippuric.acid 1 1.537 495.68 306.05
## - Phenol 1 1.693 495.83 306.14
## - Urocanic.acid 1 2.150 496.29 306.41
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.175 496.32 306.42
## - ALB..g.L. 1 2.243 496.38 306.46
## - Acetylcholine 1 2.413 496.55 306.56
## - Bilirubin 1 2.508 496.65 306.62
## - ALP..U.L. 1 2.550 496.69 306.64
## - N8.Acetylspermidine 1 2.735 496.88 306.75
## - Sphinganine.1.phosphate 1 2.813 496.95 306.80
## - Indole.3.methyl.acetate 1 2.822 496.96 306.80
## - N.Acetylcadaverine 1 3.134 497.28 306.99
## - TBA..uM. 1 3.283 497.42 307.08
## - Homovanillic.acid.sulfate 1 3.356 497.50 307.12
## <none> 494.14 307.14
## - Bilirubin.1 1 3.663 497.80 307.30
## - Phenyllactate 1 4.567 498.71 307.83
## - X2.Hydroxy.Hippuric.Acid 1 4.613 498.75 307.86
## - Cinnamoylglycine 1 4.647 498.79 307.88
## - EO.... 1 4.693 498.83 307.91
## - Imidazolepropionic.acid 1 4.844 498.98 307.99
## - N.acetyl.aspartic.acid 1 5.175 499.32 308.19
## - T.BIL..uM. 1 5.253 499.39 308.23
## - D.BIL..uM. 1 5.405 499.55 308.32
## - Indoxyl.sulfate 1 5.414 499.56 308.33
## - Cholesterol.sulfate 1 5.991 500.13 308.67
## - Phenylethylamine 1 6.173 500.31 308.77
## + Υ.GT..U.L. 1 0.100 494.04 309.08
## + UA..uM. 1 0.093 494.05 309.08
## + Oleoylethanolamide 1 0.086 494.06 309.09
## + X4.Hydroxyphenylpropionate 1 0.067 494.07 309.10
## + S.gosine.1.phosphate_b 1 0.052 494.09 309.11
## + WBC..10.9.L. 1 0.051 494.09 309.11
## + BASO.... 1 0.049 494.09 309.11
## + X3.Hydroxyphenylacetic.acid 1 0.036 494.10 309.11
## + X4.Ethylphenyl.sulfate 1 0.025 494.12 309.12
## + p.Cresol.glucuronide 1 0.025 494.12 309.12
## + LDL.C..mM. 1 0.014 494.13 309.13
## + Urea..mM. 1 0.005 494.14 309.13
## + Dopamine 1 0.004 494.14 309.13
## + Biliverdin 1 0.001 494.14 309.14
## + Enterolactone 1 0.000 494.14 309.14
## - Phenylacetylglutamine.PAGln. 1 6.967 501.11 309.24
## - X3.Hydroxyanthranilic.acid 1 7.882 502.02 309.77
## - Xanthurenic.acid 1 8.097 502.24 309.90
## - Gamma.aminobutyric.acid 1 8.348 502.49 310.04
## - X3.Hydroxyhippuric.acid 1 8.469 502.61 310.12
## - Octadecanamide 1 8.590 502.73 310.19
## - Oleamide 1 8.605 502.75 310.19
## - Kynurenic.acid 1 8.820 502.96 310.32
## - Indole.3.carboxaldehyde 1 9.066 503.21 310.46
## - S.ganine.1.phosphate_b 1 10.168 504.31 311.10
## - Ascorbic.acid 1 11.324 505.46 311.77
## - Sphinganine 1 11.495 505.64 311.87
## - LYMPH.... 1 11.916 506.06 312.12
## - NEUT.... 1 12.232 506.37 312.30
## - X5.Aminopentanoic.acid 1 14.652 508.79 313.70
## - AST..U.L. 1 14.765 508.91 313.76
## - Acetylglycine 1 16.465 510.61 314.74
## - Phenyl.sulfate 1 16.617 510.76 314.83
## - Pantothenol 1 17.963 512.10 315.60
## - X3.Hydroxypropionic.acid 1 23.072 517.21 318.51
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.509 518.65 319.32
## - ALT..U.L. 1 24.991 519.13 319.59
## - X1.5.Anhydrosorbitol 1 26.340 520.48 320.35
## - HDL.C..mM. 1 27.706 521.85 321.12
## - Indole.3.acrylic.acid 1 38.846 532.99 327.31
## - Palmitoylethanolamide 1 40.195 534.34 328.05
## - X3.Indolebutyric.acid 1 55.016 549.16 336.07
## - TG..mM. 1 80.339 574.48 349.27
##
## Step: AIC=305.22
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TC..mM. +
## TG..mM. + HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. +
## TBA..uM. + CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + Phenylacetic.acid + X3.Hydroxybenzoic.acid +
## X4.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Phenylacetic.acid 1 0.130 494.41 303.30
## - TC..mM. 1 0.148 494.43 303.31
## - Sphingosine 1 0.159 494.44 303.31
## - X4.Hydroxybenzoic.acid 1 0.229 494.51 303.36
## - Putrescine 1 0.234 494.52 303.36
## - Palmitic.amide 1 0.249 494.53 303.37
## - p.Cresol 1 0.273 494.56 303.38
## - Benzoic.acid 1 0.315 494.60 303.41
## - CHE..U.L. 1 0.351 494.63 303.43
## - p.Cresol.sulfate 1 0.357 494.64 303.43
## - Stearoylethanolamide 1 0.475 494.76 303.50
## - Indole.3.propionic.acid 1 0.610 494.89 303.58
## - Sphingosine.1.phosphate 1 0.648 494.93 303.60
## - Spermine 1 0.702 494.98 303.64
## - X5.Methoxyindoleacetate 1 0.757 495.04 303.67
## - Spermidine 1 0.776 495.06 303.68
## - X4.Hydroxyphenyllactate 1 0.813 495.10 303.70
## - Iodide 1 0.926 495.21 303.77
## - X3.Hydroxybenzoic.acid 1 0.948 495.23 303.78
## - Salicylic.acid 1 1.180 495.46 303.92
## - Hippuric.acid 1 1.426 495.71 304.06
## - Cre..uM. 1 1.537 495.82 304.13
## - Phenol 1 1.733 496.02 304.25
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.122 496.40 304.48
## - ALB..g.L. 1 2.165 496.45 304.50
## - Urocanic.acid 1 2.335 496.62 304.60
## - Bilirubin 1 2.415 496.70 304.65
## - ALP..U.L. 1 2.681 496.96 304.80
## - N8.Acetylspermidine 1 2.685 496.97 304.81
## - Indole.3.methyl.acetate 1 2.820 497.10 304.89
## - Sphinganine.1.phosphate 1 2.838 497.12 304.90
## - Acetylcholine 1 3.045 497.33 305.02
## - TBA..uM. 1 3.256 497.54 305.14
## - N.Acetylcadaverine 1 3.373 497.66 305.21
## <none> 494.28 305.22
## - Homovanillic.acid.sulfate 1 3.534 497.82 305.31
## - Bilirubin.1 1 3.607 497.89 305.35
## - Phenyllactate 1 4.561 498.84 305.91
## - Cinnamoylglycine 1 4.599 498.88 305.93
## - EO.... 1 4.607 498.89 305.94
## - X2.Hydroxy.Hippuric.Acid 1 4.772 499.05 306.03
## - N.acetyl.aspartic.acid 1 5.059 499.34 306.20
## - T.BIL..uM. 1 5.131 499.41 306.25
## - D.BIL..uM. 1 5.324 499.61 306.36
## - Indoxyl.sulfate 1 5.494 499.78 306.46
## - Imidazolepropionic.acid 1 5.553 499.84 306.49
## - Cholesterol.sulfate 1 6.041 500.32 306.78
## - Phenylethylamine 1 6.121 500.40 306.83
## + Dopa 1 0.142 494.14 307.14
## + Υ.GT..U.L. 1 0.133 494.15 307.14
## + X4.Hydroxyphenylpropionate 1 0.107 494.18 307.16
## + UA..uM. 1 0.106 494.18 307.16
## + BASO.... 1 0.067 494.22 307.18
## + Oleoylethanolamide 1 0.065 494.22 307.18
## + WBC..10.9.L. 1 0.051 494.23 307.19
## + X3.Hydroxyphenylacetic.acid 1 0.049 494.23 307.19
## + S.gosine.1.phosphate_b 1 0.048 494.24 307.19
## + p.Cresol.glucuronide 1 0.044 494.24 307.19
## + X4.Ethylphenyl.sulfate 1 0.031 494.25 307.20
## + Urea..mM. 1 0.010 494.27 307.21
## + LDL.C..mM. 1 0.010 494.27 307.21
## + Dopamine 1 0.008 494.27 307.22
## + Biliverdin 1 0.000 494.28 307.22
## + Enterolactone 1 0.000 494.28 307.22
## - Phenylacetylglutamine.PAGln. 1 6.870 501.15 307.26
## - Xanthurenic.acid 1 8.081 502.36 307.97
## - X3.Hydroxyanthranilic.acid 1 8.253 502.54 308.07
## - Gamma.aminobutyric.acid 1 8.427 502.71 308.17
## - Octadecanamide 1 8.526 502.81 308.23
## - X3.Hydroxyhippuric.acid 1 8.587 502.87 308.27
## - Kynurenic.acid 1 8.682 502.96 308.32
## - Oleamide 1 8.763 503.05 308.37
## - Indole.3.carboxaldehyde 1 9.183 503.47 308.61
## - S.ganine.1.phosphate_b 1 10.200 504.48 309.20
## - Ascorbic.acid 1 11.216 505.50 309.79
## - Sphinganine 1 11.433 505.72 309.92
## - LYMPH.... 1 11.869 506.15 310.17
## - NEUT.... 1 12.288 506.57 310.42
## - AST..U.L. 1 14.807 509.09 311.87
## - Acetylglycine 1 16.337 510.62 312.75
## - Phenyl.sulfate 1 16.589 510.87 312.89
## - X5.Aminopentanoic.acid 1 16.591 510.87 312.89
## - Pantothenol 1 17.856 512.14 313.62
## - X3.Hydroxypropionic.acid 1 23.242 517.52 316.68
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.656 518.94 317.48
## - ALT..U.L. 1 25.188 519.47 317.78
## - X1.5.Anhydrosorbitol 1 26.629 520.91 318.59
## - HDL.C..mM. 1 27.699 521.98 319.20
## - Indole.3.acrylic.acid 1 39.233 533.52 325.60
## - Palmitoylethanolamide 1 40.721 535.00 326.42
## - X3.Indolebutyric.acid 1 54.881 549.16 334.07
## - TG..mM. 1 80.313 574.60 347.33
##
## Step: AIC=303.3
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TC..mM. +
## TG..mM. + HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. +
## TBA..uM. + CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - TC..mM. 1 0.177 494.59 301.40
## - Sphingosine 1 0.186 494.60 301.41
## - X4.Hydroxybenzoic.acid 1 0.213 494.63 301.42
## - Palmitic.amide 1 0.230 494.64 301.43
## - p.Cresol 1 0.243 494.66 301.44
## - Putrescine 1 0.257 494.67 301.45
## - Benzoic.acid 1 0.289 494.70 301.47
## - CHE..U.L. 1 0.358 494.77 301.51
## - p.Cresol.sulfate 1 0.424 494.84 301.55
## - Stearoylethanolamide 1 0.466 494.88 301.57
## - Indole.3.propionic.acid 1 0.618 495.03 301.66
## - Spermine 1 0.663 495.08 301.69
## - Sphingosine.1.phosphate 1 0.667 495.08 301.69
## - X5.Methoxyindoleacetate 1 0.751 495.16 301.74
## - Spermidine 1 0.765 495.18 301.75
## - X4.Hydroxyphenyllactate 1 0.777 495.19 301.76
## - X3.Hydroxybenzoic.acid 1 0.905 495.32 301.83
## - Iodide 1 0.940 495.35 301.85
## - Salicylic.acid 1 1.146 495.56 301.98
## - Hippuric.acid 1 1.393 495.81 302.12
## - Cre..uM. 1 1.478 495.89 302.17
## - Phenol 1 1.750 496.16 302.33
## - ALB..g.L. 1 2.189 496.60 302.59
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.225 496.64 302.61
## - Urocanic.acid 1 2.354 496.77 302.69
## - Bilirubin 1 2.498 496.91 302.77
## - ALP..U.L. 1 2.636 497.05 302.86
## - N8.Acetylspermidine 1 2.717 497.13 302.90
## - Indole.3.methyl.acetate 1 2.814 497.23 302.96
## - Sphinganine.1.phosphate 1 2.892 497.31 303.01
## - Acetylcholine 1 3.115 497.53 303.14
## - TBA..uM. 1 3.220 497.63 303.20
## <none> 494.41 303.30
## - N.Acetylcadaverine 1 3.391 497.80 303.30
## - Homovanillic.acid.sulfate 1 3.496 497.91 303.36
## - Bilirubin.1 1 3.641 498.05 303.45
## - EO.... 1 4.488 498.90 303.94
## - Phenyllactate 1 4.493 498.91 303.95
## - Cinnamoylglycine 1 4.729 499.14 304.09
## - X2.Hydroxy.Hippuric.Acid 1 4.757 499.17 304.10
## - N.acetyl.aspartic.acid 1 5.046 499.46 304.27
## - T.BIL..uM. 1 5.075 499.49 304.29
## - D.BIL..uM. 1 5.317 499.73 304.43
## - Imidazolepropionic.acid 1 5.600 500.01 304.60
## - Indoxyl.sulfate 1 5.660 500.07 304.63
## - Cholesterol.sulfate 1 5.913 500.33 304.78
## - Phenylethylamine 1 6.231 500.64 304.97
## + Phenylacetic.acid 1 0.130 494.28 305.22
## + Υ.GT..U.L. 1 0.127 494.29 305.22
## + Dopa 1 0.118 494.29 305.23
## + UA..uM. 1 0.106 494.31 305.23
## + X4.Hydroxyphenylpropionate 1 0.104 494.31 305.24
## + X3.Hydroxyphenylacetic.acid 1 0.074 494.34 305.25
## + Oleoylethanolamide 1 0.073 494.34 305.25
## + BASO.... 1 0.071 494.34 305.26
## + p.Cresol.glucuronide 1 0.060 494.35 305.26
## + WBC..10.9.L. 1 0.047 494.37 305.27
## + S.gosine.1.phosphate_b 1 0.036 494.38 305.28
## + Dopamine 1 0.033 494.38 305.28
## + X4.Ethylphenyl.sulfate 1 0.029 494.38 305.28
## + LDL.C..mM. 1 0.012 494.40 305.29
## + Urea..mM. 1 0.009 494.40 305.29
## + Biliverdin 1 0.001 494.41 305.30
## + Enterolactone 1 0.000 494.41 305.30
## - Phenylacetylglutamine.PAGln. 1 6.820 501.23 305.31
## - X3.Hydroxyanthranilic.acid 1 8.168 502.58 306.10
## - Xanthurenic.acid 1 8.177 502.59 306.10
## - Octadecanamide 1 8.411 502.82 306.24
## - X3.Hydroxyhippuric.acid 1 8.476 502.89 306.28
## - Kynurenic.acid 1 8.597 503.01 306.35
## - Gamma.aminobutyric.acid 1 8.623 503.04 306.36
## - Oleamide 1 8.646 503.06 306.38
## - Indole.3.carboxaldehyde 1 9.125 503.54 306.66
## - S.ganine.1.phosphate_b 1 10.397 504.81 307.39
## - Ascorbic.acid 1 11.391 505.80 307.97
## - Sphinganine 1 11.671 506.08 308.13
## - LYMPH.... 1 11.751 506.16 308.18
## - NEUT.... 1 12.194 506.61 308.44
## - AST..U.L. 1 14.792 509.21 309.93
## - Phenyl.sulfate 1 16.538 510.95 310.94
## - X5.Aminopentanoic.acid 1 16.755 511.17 311.06
## - Acetylglycine 1 17.021 511.43 311.21
## - Pantothenol 1 18.749 513.16 312.20
## - X3.Hydroxypropionic.acid 1 23.351 517.76 314.82
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.651 519.06 315.55
## - ALT..U.L. 1 25.258 519.67 315.90
## - X1.5.Anhydrosorbitol 1 26.929 521.34 316.84
## - HDL.C..mM. 1 27.577 521.99 317.20
## - Indole.3.acrylic.acid 1 39.246 533.66 323.68
## - Palmitoylethanolamide 1 40.655 535.07 324.45
## - X3.Indolebutyric.acid 1 55.413 549.83 332.42
## - TG..mM. 1 80.189 574.60 345.34
##
## Step: AIC=301.4
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## Sphingosine + X3.Indolebutyric.acid + Sphingosine.1.phosphate +
## X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Putrescine + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol +
## Benzoic.acid + X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Sphingosine 1 0.158 494.75 299.50
## - X4.Hydroxybenzoic.acid 1 0.197 494.79 299.52
## - Palmitic.amide 1 0.215 494.80 299.53
## - p.Cresol 1 0.236 494.83 299.54
## - Putrescine 1 0.262 494.85 299.56
## - Benzoic.acid 1 0.343 494.93 299.60
## - CHE..U.L. 1 0.379 494.97 299.63
## - p.Cresol.sulfate 1 0.432 495.02 299.66
## - Stearoylethanolamide 1 0.500 495.09 299.70
## - Sphingosine.1.phosphate 1 0.620 495.21 299.77
## - Indole.3.propionic.acid 1 0.623 495.21 299.77
## - Spermine 1 0.640 495.23 299.78
## - X5.Methoxyindoleacetate 1 0.741 495.33 299.84
## - X4.Hydroxyphenyllactate 1 0.762 495.35 299.85
## - Spermidine 1 0.793 495.38 299.87
## - X3.Hydroxybenzoic.acid 1 0.853 495.44 299.91
## - Iodide 1 0.890 495.48 299.93
## - Salicylic.acid 1 1.125 495.71 300.07
## - Hippuric.acid 1 1.426 496.02 300.25
## - Cre..uM. 1 1.543 496.13 300.31
## - Phenol 1 1.745 496.33 300.43
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.211 496.80 300.71
## - ALB..g.L. 1 2.212 496.80 300.71
## - Urocanic.acid 1 2.368 496.96 300.80
## - Bilirubin 1 2.477 497.07 300.87
## - ALP..U.L. 1 2.517 497.11 300.89
## - N8.Acetylspermidine 1 2.697 497.29 300.99
## - Indole.3.methyl.acetate 1 2.827 497.42 301.07
## - Sphinganine.1.phosphate 1 2.856 497.45 301.09
## - TBA..uM. 1 3.270 497.86 301.33
## - Acetylcholine 1 3.281 497.87 301.34
## - N.Acetylcadaverine 1 3.384 497.97 301.40
## <none> 494.59 301.40
## - Homovanillic.acid.sulfate 1 3.513 498.10 301.48
## - Bilirubin.1 1 3.615 498.20 301.54
## - EO.... 1 4.432 499.02 302.02
## - Phenyllactate 1 4.553 499.14 302.09
## - X2.Hydroxy.Hippuric.Acid 1 4.886 499.47 302.28
## - Cinnamoylglycine 1 4.966 499.56 302.33
## - N.acetyl.aspartic.acid 1 5.176 499.77 302.45
## - T.BIL..uM. 1 5.449 500.04 302.61
## - Indoxyl.sulfate 1 5.616 500.21 302.71
## - Imidazolepropionic.acid 1 5.665 500.25 302.74
## - D.BIL..uM. 1 5.800 500.39 302.82
## - Cholesterol.sulfate 1 5.967 500.56 302.92
## - Phenylethylamine 1 6.246 500.84 303.08
## + TC..mM. 1 0.177 494.41 303.30
## + Phenylacetic.acid 1 0.158 494.43 303.31
## + Υ.GT..U.L. 1 0.128 494.46 303.33
## + Dopa 1 0.111 494.48 303.34
## + X4.Hydroxyphenylpropionate 1 0.100 494.49 303.34
## + Oleoylethanolamide 1 0.097 494.49 303.34
## + UA..uM. 1 0.081 494.51 303.35
## + BASO.... 1 0.057 494.53 303.37
## + X3.Hydroxyphenylacetic.acid 1 0.056 494.53 303.37
## + p.Cresol.glucuronide 1 0.052 494.54 303.37
## + WBC..10.9.L. 1 0.051 494.54 303.37
## + S.gosine.1.phosphate_b 1 0.035 494.55 303.38
## + X4.Ethylphenyl.sulfate 1 0.034 494.56 303.38
## + Dopamine 1 0.020 494.57 303.39
## + Urea..mM. 1 0.018 494.57 303.39
## + Biliverdin 1 0.006 494.58 303.40
## + LDL.C..mM. 1 0.001 494.59 303.40
## + Enterolactone 1 0.000 494.59 303.40
## - Phenylacetylglutamine.PAGln. 1 6.828 501.42 303.42
## - X3.Hydroxyanthranilic.acid 1 8.062 502.65 304.14
## - Xanthurenic.acid 1 8.130 502.72 304.18
## - X3.Hydroxyhippuric.acid 1 8.348 502.94 304.31
## - Kynurenic.acid 1 8.499 503.09 304.39
## - Gamma.aminobutyric.acid 1 8.529 503.12 304.41
## - Octadecanamide 1 8.596 503.18 304.45
## - Oleamide 1 8.751 503.34 304.54
## - Indole.3.carboxaldehyde 1 9.400 503.99 304.92
## - S.ganine.1.phosphate_b 1 10.249 504.84 305.41
## - Ascorbic.acid 1 11.411 506.00 306.08
## - Sphinganine 1 11.502 506.09 306.14
## - LYMPH.... 1 11.678 506.27 306.24
## - NEUT.... 1 12.099 506.69 306.48
## - AST..U.L. 1 14.621 509.21 307.94
## - Phenyl.sulfate 1 16.543 511.13 309.04
## - X5.Aminopentanoic.acid 1 17.304 511.89 309.48
## - Acetylglycine 1 17.588 512.18 309.64
## - Pantothenol 1 19.124 513.71 310.52
## - X3.Hydroxypropionic.acid 1 23.273 517.86 312.87
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.544 519.13 313.59
## - ALT..U.L. 1 25.193 519.78 313.96
## - X1.5.Anhydrosorbitol 1 27.196 521.78 315.09
## - HDL.C..mM. 1 27.637 522.23 315.33
## - Indole.3.acrylic.acid 1 39.443 534.03 321.88
## - Palmitoylethanolamide 1 40.582 535.17 322.51
## - X3.Indolebutyric.acid 1 55.256 549.85 330.43
## - TG..mM. 1 80.103 574.69 343.38
##
## Step: AIC=299.5
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## X3.Hydroxybenzoic.acid + X4.Hydroxybenzoic.acid + Salicylic.acid +
## Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - X4.Hydroxybenzoic.acid 1 0.169 494.92 297.60
## - p.Cresol 1 0.196 494.94 297.61
## - Palmitic.amide 1 0.254 495.00 297.65
## - Putrescine 1 0.258 495.00 297.65
## - Benzoic.acid 1 0.397 495.14 297.73
## - CHE..U.L. 1 0.404 495.15 297.73
## - p.Cresol.sulfate 1 0.478 495.22 297.78
## - Sphingosine.1.phosphate 1 0.508 495.26 297.80
## - Stearoylethanolamide 1 0.523 495.27 297.80
## - Indole.3.propionic.acid 1 0.664 495.41 297.89
## - Spermine 1 0.715 495.46 297.92
## - X5.Methoxyindoleacetate 1 0.753 495.50 297.94
## - X4.Hydroxyphenyllactate 1 0.820 495.57 297.98
## - Spermidine 1 0.847 495.59 298.00
## - Iodide 1 0.876 495.62 298.01
## - X3.Hydroxybenzoic.acid 1 0.942 495.69 298.05
## - Salicylic.acid 1 1.060 495.81 298.12
## - Hippuric.acid 1 1.430 496.18 298.34
## - Cre..uM. 1 1.453 496.20 298.35
## - Phenol 1 1.745 496.49 298.53
## - ALB..g.L. 1 2.188 496.93 298.79
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.228 496.97 298.81
## - Urocanic.acid 1 2.315 497.06 298.86
## - ALP..U.L. 1 2.400 497.15 298.91
## - Bilirubin 1 2.466 497.21 298.95
## - N8.Acetylspermidine 1 2.622 497.37 299.04
## - Sphinganine.1.phosphate 1 2.765 497.51 299.13
## - Indole.3.methyl.acetate 1 2.938 497.69 299.23
## - TBA..uM. 1 3.327 498.07 299.46
## - Acetylcholine 1 3.344 498.09 299.47
## <none> 494.75 299.50
## - N.Acetylcadaverine 1 3.458 498.21 299.54
## - Bilirubin.1 1 3.610 498.36 299.63
## - Homovanillic.acid.sulfate 1 3.617 498.36 299.63
## - Phenyllactate 1 4.527 499.27 300.16
## - EO.... 1 4.532 499.28 300.17
## - X2.Hydroxy.Hippuric.Acid 1 4.794 499.54 300.32
## - Cinnamoylglycine 1 4.929 499.68 300.40
## - N.acetyl.aspartic.acid 1 5.028 499.78 300.46
## - T.BIL..uM. 1 5.308 500.05 300.62
## - D.BIL..uM. 1 5.652 500.40 300.82
## - Indoxyl.sulfate 1 5.790 500.54 300.90
## - Imidazolepropionic.acid 1 5.901 500.65 300.97
## - Cholesterol.sulfate 1 6.015 500.76 301.04
## - Phenylethylamine 1 6.093 500.84 301.08
## + Phenylacetic.acid 1 0.183 494.56 301.39
## + Sphingosine 1 0.158 494.59 301.40
## + TC..mM. 1 0.149 494.60 301.41
## + Υ.GT..U.L. 1 0.124 494.62 301.42
## + Oleoylethanolamide 1 0.119 494.63 301.42
## + Dopa 1 0.106 494.64 301.43
## + UA..uM. 1 0.100 494.65 301.44
## + p.Cresol.glucuronide 1 0.082 494.67 301.45
## + X4.Hydroxyphenylpropionate 1 0.063 494.68 301.46
## + X3.Hydroxyphenylacetic.acid 1 0.051 494.70 301.47
## - Phenylacetylglutamine.PAGln. 1 6.758 501.51 301.47
## + WBC..10.9.L. 1 0.041 494.71 301.47
## + BASO.... 1 0.040 494.71 301.47
## + X4.Ethylphenyl.sulfate 1 0.039 494.71 301.47
## + S.gosine.1.phosphate_b 1 0.019 494.73 301.48
## + Dopamine 1 0.015 494.73 301.49
## + Urea..mM. 1 0.007 494.74 301.49
## + Biliverdin 1 0.006 494.74 301.49
## + LDL.C..mM. 1 0.001 494.75 301.49
## + Enterolactone 1 0.000 494.75 301.50
## - X3.Hydroxyanthranilic.acid 1 7.950 502.70 302.17
## - Xanthurenic.acid 1 8.077 502.82 302.24
## - X3.Hydroxyhippuric.acid 1 8.371 503.12 302.41
## - Gamma.aminobutyric.acid 1 8.372 503.12 302.41
## - Kynurenic.acid 1 8.515 503.26 302.50
## - Octadecanamide 1 8.841 503.59 302.68
## - Oleamide 1 8.893 503.64 302.71
## - Indole.3.carboxaldehyde 1 9.326 504.07 302.97
## - S.ganine.1.phosphate_b 1 10.220 504.97 303.49
## - Ascorbic.acid 1 11.356 506.10 304.14
## - LYMPH.... 1 11.520 506.27 304.24
## - NEUT.... 1 11.952 506.70 304.49
## - AST..U.L. 1 14.479 509.23 305.95
## - Phenyl.sulfate 1 16.487 511.23 307.10
## - Acetylglycine 1 17.451 512.20 307.65
## - X5.Aminopentanoic.acid 1 17.784 512.53 307.84
## - Pantothenol 1 19.280 514.03 308.70
## - X3.Hydroxypropionic.acid 1 23.152 517.90 310.89
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.815 519.56 311.83
## - ALT..U.L. 1 25.430 520.18 312.18
## - Sphinganine 1 26.639 521.39 312.86
## - X1.5.Anhydrosorbitol 1 27.215 521.96 313.18
## - HDL.C..mM. 1 28.938 523.69 314.15
## - Indole.3.acrylic.acid 1 40.280 535.03 320.43
## - Palmitoylethanolamide 1 40.766 535.51 320.69
## - X3.Indolebutyric.acid 1 55.201 549.95 328.49
## - TG..mM. 1 80.547 575.29 341.69
##
## Step: AIC=297.6
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + p.Cresol + X1.5.Anhydrosorbitol + Benzoic.acid +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - p.Cresol 1 0.201 495.12 295.71
## - Palmitic.amide 1 0.224 495.14 295.73
## - Putrescine 1 0.259 495.17 295.75
## - Benzoic.acid 1 0.358 495.27 295.81
## - p.Cresol.sulfate 1 0.454 495.37 295.86
## - Sphingosine.1.phosphate 1 0.473 495.39 295.87
## - CHE..U.L. 1 0.487 495.40 295.88
## - Stearoylethanolamide 1 0.522 495.44 295.90
## - Indole.3.propionic.acid 1 0.670 495.59 295.99
## - Spermine 1 0.692 495.61 296.00
## - X5.Methoxyindoleacetate 1 0.724 495.64 296.02
## - X4.Hydroxyphenyllactate 1 0.803 495.72 296.07
## - Iodide 1 0.919 495.84 296.14
## - Spermidine 1 0.941 495.86 296.15
## - X3.Hydroxybenzoic.acid 1 0.964 495.88 296.17
## - Hippuric.acid 1 1.489 496.41 296.48
## - Cre..uM. 1 1.630 496.55 296.56
## - Phenol 1 1.709 496.63 296.61
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.229 497.15 296.91
## - ALB..g.L. 1 2.247 497.16 296.92
## - ALP..U.L. 1 2.304 497.22 296.96
## - Urocanic.acid 1 2.349 497.27 296.98
## - N8.Acetylspermidine 1 2.562 497.48 297.11
## - Bilirubin 1 2.612 497.53 297.14
## - Sphinganine.1.phosphate 1 2.827 497.74 297.26
## - Indole.3.methyl.acetate 1 2.954 497.87 297.34
## - Acetylcholine 1 3.322 498.24 297.56
## - N.Acetylcadaverine 1 3.351 498.27 297.57
## - TBA..uM. 1 3.351 498.27 297.57
## <none> 494.92 297.60
## - Homovanillic.acid.sulfate 1 3.783 498.70 297.83
## - Bilirubin.1 1 3.794 498.71 297.83
## - EO.... 1 4.374 499.29 298.17
## - Phenyllactate 1 4.618 499.53 298.32
## - X2.Hydroxy.Hippuric.Acid 1 4.738 499.65 298.39
## - Cinnamoylglycine 1 4.857 499.77 298.46
## - N.acetyl.aspartic.acid 1 5.188 500.10 298.65
## - T.BIL..uM. 1 5.337 500.25 298.74
## - D.BIL..uM. 1 5.675 500.59 298.94
## - Imidazolepropionic.acid 1 5.826 500.74 299.02
## - Indoxyl.sulfate 1 5.830 500.75 299.03
## - Phenylethylamine 1 5.971 500.89 299.11
## - Cholesterol.sulfate 1 6.121 501.04 299.20
## + X4.Hydroxybenzoic.acid 1 0.169 494.75 299.50
## + Phenylacetic.acid 1 0.161 494.76 299.50
## - Phenylacetylglutamine.PAGln. 1 6.648 501.56 299.50
## + TC..mM. 1 0.137 494.78 299.51
## + Sphingosine 1 0.130 494.79 299.52
## + Dopa 1 0.127 494.79 299.52
## + Υ.GT..U.L. 1 0.113 494.80 299.53
## + Oleoylethanolamide 1 0.106 494.81 299.53
## + UA..uM. 1 0.099 494.82 299.54
## + p.Cresol.glucuronide 1 0.088 494.83 299.54
## + X4.Hydroxyphenylpropionate 1 0.059 494.86 299.56
## + X3.Hydroxyphenylacetic.acid 1 0.057 494.86 299.56
## + WBC..10.9.L. 1 0.056 494.86 299.56
## + X4.Ethylphenyl.sulfate 1 0.053 494.86 299.56
## + S.gosine.1.phosphate_b 1 0.033 494.88 299.58
## + BASO.... 1 0.029 494.89 299.58
## + Dopamine 1 0.010 494.91 299.59
## + Urea..mM. 1 0.008 494.91 299.59
## + Biliverdin 1 0.006 494.91 299.59
## + LDL.C..mM. 1 0.002 494.91 299.59
## + Enterolactone 1 0.000 494.92 299.59
## - Salicylic.acid 1 7.147 502.06 299.80
## - X3.Hydroxyanthranilic.acid 1 7.838 502.75 300.20
## - Xanthurenic.acid 1 7.908 502.82 300.24
## - X3.Hydroxyhippuric.acid 1 8.278 503.19 300.46
## - Kynurenic.acid 1 8.356 503.27 300.50
## - Gamma.aminobutyric.acid 1 8.527 503.44 300.60
## - Octadecanamide 1 8.936 503.85 300.84
## - Indole.3.carboxaldehyde 1 9.165 504.08 300.97
## - Oleamide 1 9.281 504.20 301.04
## - S.ganine.1.phosphate_b 1 10.304 505.22 301.63
## - LYMPH.... 1 11.433 506.35 302.29
## - NEUT.... 1 11.967 506.88 302.60
## - Ascorbic.acid 1 13.286 508.20 303.36
## - AST..U.L. 1 14.340 509.26 303.96
## - Phenyl.sulfate 1 16.501 511.42 305.20
## - X5.Aminopentanoic.acid 1 17.831 512.75 305.97
## - Acetylglycine 1 18.143 513.06 306.14
## - Pantothenol 1 19.214 514.13 306.75
## - X3.Hydroxypropionic.acid 1 22.983 517.90 308.90
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.787 519.70 309.91
## - ALT..U.L. 1 25.318 520.23 310.21
## - Sphinganine 1 26.685 521.60 310.98
## - X1.5.Anhydrosorbitol 1 27.155 522.07 311.25
## - HDL.C..mM. 1 28.797 523.71 312.17
## - Indole.3.acrylic.acid 1 40.370 535.29 318.57
## - Palmitoylethanolamide 1 40.778 535.69 318.79
## - X3.Indolebutyric.acid 1 55.055 549.97 326.50
## - TG..mM. 1 81.026 575.94 340.02
##
## Step: AIC=295.71
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitic.amide + Palmitoylethanolamide + Stearoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + Benzoic.acid +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Palmitic.amide 1 0.225 495.34 293.85
## - Putrescine 1 0.318 495.44 293.90
## - Benzoic.acid 1 0.390 495.51 293.95
## - Sphingosine.1.phosphate 1 0.467 495.59 293.99
## - Stearoylethanolamide 1 0.534 495.65 294.03
## - CHE..U.L. 1 0.615 495.73 294.08
## - Indole.3.propionic.acid 1 0.648 495.77 294.10
## - Spermine 1 0.712 495.83 294.14
## - X5.Methoxyindoleacetate 1 0.814 495.93 294.20
## - Spermidine 1 0.915 496.03 294.26
## - Iodide 1 0.935 496.05 294.27
## - X3.Hydroxybenzoic.acid 1 0.997 496.11 294.30
## - X4.Hydroxyphenyllactate 1 1.010 496.13 294.31
## - Hippuric.acid 1 1.360 496.48 294.52
## - Cre..uM. 1 1.640 496.76 294.68
## - Phenol 1 1.842 496.96 294.80
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.033 497.15 294.92
## - ALB..g.L. 1 2.183 497.30 295.00
## - ALP..U.L. 1 2.283 497.40 295.06
## - Urocanic.acid 1 2.373 497.49 295.12
## - N8.Acetylspermidine 1 2.416 497.53 295.14
## - Bilirubin 1 2.670 497.79 295.29
## - Sphinganine.1.phosphate 1 2.702 497.82 295.31
## - Indole.3.methyl.acetate 1 2.915 498.03 295.43
## <none> 495.12 295.71
## - TBA..uM. 1 3.418 498.54 295.73
## - N.Acetylcadaverine 1 3.496 498.61 295.78
## - Homovanillic.acid.sulfate 1 3.700 498.82 295.90
## - Acetylcholine 1 3.731 498.85 295.91
## - Bilirubin.1 1 3.920 499.04 296.03
## - EO.... 1 4.380 499.50 296.30
## - Cinnamoylglycine 1 4.742 499.86 296.51
## - X2.Hydroxy.Hippuric.Acid 1 4.869 499.99 296.58
## - N.acetyl.aspartic.acid 1 5.180 500.30 296.76
## - Phenyllactate 1 5.279 500.40 296.82
## - T.BIL..uM. 1 5.535 500.65 296.97
## - Imidazolepropionic.acid 1 5.693 500.81 297.06
## - Indoxyl.sulfate 1 5.759 500.88 297.10
## - D.BIL..uM. 1 5.864 500.98 297.16
## - Phenylethylamine 1 5.875 500.99 297.17
## - Phenylacetylglutamine.PAGln. 1 6.472 501.59 297.52
## + p.Cresol 1 0.201 494.92 297.60
## + X4.Hydroxybenzoic.acid 1 0.175 494.94 297.61
## + TC..mM. 1 0.134 494.98 297.64
## + Υ.GT..U.L. 1 0.131 494.99 297.64
## + Phenylacetic.acid 1 0.127 494.99 297.64
## + UA..uM. 1 0.111 495.01 297.65
## + Dopa 1 0.106 495.01 297.65
## + Sphingosine 1 0.093 495.02 297.66
## + X4.Hydroxyphenylpropionate 1 0.080 495.04 297.67
## + X3.Hydroxyphenylacetic.acid 1 0.079 495.04 297.67
## + Oleoylethanolamide 1 0.077 495.04 297.67
## + WBC..10.9.L. 1 0.048 495.07 297.69
## + p.Cresol.glucuronide 1 0.043 495.08 297.69
## + BASO.... 1 0.040 495.08 297.69
## + S.gosine.1.phosphate_b 1 0.034 495.08 297.69
## + X4.Ethylphenyl.sulfate 1 0.028 495.09 297.70
## + Biliverdin 1 0.009 495.11 297.71
## + Dopamine 1 0.008 495.11 297.71
## + Urea..mM. 1 0.004 495.11 297.71
## + Enterolactone 1 0.003 495.11 297.71
## + LDL.C..mM. 1 0.000 495.12 297.71
## - Cholesterol.sulfate 1 6.903 502.02 297.77
## - Salicylic.acid 1 7.316 502.43 298.01
## - Xanthurenic.acid 1 7.832 502.95 298.31
## - X3.Hydroxyanthranilic.acid 1 8.085 503.20 298.46
## - X3.Hydroxyhippuric.acid 1 8.110 503.23 298.47
## - Gamma.aminobutyric.acid 1 8.409 503.53 298.65
## - p.Cresol.sulfate 1 8.497 503.61 298.70
## - Kynurenic.acid 1 8.652 503.77 298.79
## - Indole.3.carboxaldehyde 1 9.101 504.22 299.05
## - Octadecanamide 1 9.139 504.26 299.07
## - Oleamide 1 9.209 504.33 299.11
## - S.ganine.1.phosphate_b 1 10.195 505.31 299.69
## - LYMPH.... 1 11.327 506.44 300.34
## - NEUT.... 1 11.873 506.99 300.66
## - Ascorbic.acid 1 13.154 508.27 301.40
## - AST..U.L. 1 14.403 509.52 302.12
## - Phenyl.sulfate 1 16.962 512.08 303.58
## - X5.Aminopentanoic.acid 1 17.781 512.90 304.05
## - Acetylglycine 1 18.256 513.37 304.32
## - Pantothenol 1 19.238 514.36 304.88
## - X3.Hydroxypropionic.acid 1 22.816 517.93 306.91
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.593 519.71 307.92
## - ALT..U.L. 1 25.138 520.26 308.23
## - X1.5.Anhydrosorbitol 1 27.054 522.17 309.30
## - Sphinganine 1 27.259 522.38 309.42
## - HDL.C..mM. 1 29.447 524.56 310.64
## - Indole.3.acrylic.acid 1 40.784 535.90 316.91
## - Palmitoylethanolamide 1 41.090 536.21 317.07
## - X3.Indolebutyric.acid 1 54.915 550.03 324.53
## - TG..mM. 1 81.283 576.40 338.25
##
## Step: AIC=293.85
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Putrescine +
## Gamma.aminobutyric.acid + X5.Aminopentanoic.acid + N.Acetylcadaverine +
## Acetylcholine + Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + Benzoic.acid +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Putrescine 1 0.261 495.60 292.00
## - Benzoic.acid 1 0.380 495.72 292.07
## - Sphingosine.1.phosphate 1 0.532 495.87 292.16
## - Stearoylethanolamide 1 0.547 495.89 292.17
## - CHE..U.L. 1 0.569 495.91 292.18
## - Indole.3.propionic.acid 1 0.614 495.96 292.21
## - Spermine 1 0.684 496.03 292.25
## - X5.Methoxyindoleacetate 1 0.821 496.16 292.33
## - Iodide 1 0.883 496.23 292.37
## - X4.Hydroxyphenyllactate 1 0.949 496.29 292.41
## - Spermidine 1 0.979 496.32 292.43
## - X3.Hydroxybenzoic.acid 1 0.986 496.33 292.43
## - Hippuric.acid 1 1.321 496.66 292.63
## - Cre..uM. 1 1.723 497.07 292.86
## - Phenol 1 1.818 497.16 292.92
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.951 497.29 293.00
## - ALP..U.L. 1 2.249 497.59 293.17
## - ALB..g.L. 1 2.378 497.72 293.25
## - Sphinganine.1.phosphate 1 2.508 497.85 293.33
## - N8.Acetylspermidine 1 2.512 497.85 293.33
## - Urocanic.acid 1 2.584 497.93 293.37
## - Bilirubin 1 2.829 498.17 293.52
## - Indole.3.methyl.acetate 1 2.871 498.21 293.54
## - TBA..uM. 1 3.340 498.68 293.82
## <none> 495.34 293.85
## - N.Acetylcadaverine 1 3.421 498.76 293.86
## - Acetylcholine 1 3.685 499.03 294.02
## - Homovanillic.acid.sulfate 1 3.771 499.11 294.07
## - Bilirubin.1 1 4.207 499.55 294.33
## - EO.... 1 4.346 499.69 294.41
## - Cinnamoylglycine 1 4.673 500.02 294.60
## - X2.Hydroxy.Hippuric.Acid 1 5.058 500.40 294.82
## - N.acetyl.aspartic.acid 1 5.110 500.45 294.85
## - Phenyllactate 1 5.141 500.48 294.87
## - T.BIL..uM. 1 5.661 501.00 295.18
## - Indoxyl.sulfate 1 5.771 501.11 295.24
## - Phenylethylamine 1 5.866 501.21 295.30
## - Imidazolepropionic.acid 1 5.973 501.32 295.36
## - D.BIL..uM. 1 6.017 501.36 295.39
## - Phenylacetylglutamine.PAGln. 1 6.297 501.64 295.55
## + Palmitic.amide 1 0.225 495.12 295.71
## + p.Cresol 1 0.203 495.14 295.73
## + Υ.GT..U.L. 1 0.168 495.17 295.75
## + X4.Hydroxybenzoic.acid 1 0.144 495.20 295.76
## + Sphingosine 1 0.124 495.22 295.77
## + TC..mM. 1 0.120 495.22 295.78
## + Phenylacetic.acid 1 0.110 495.23 295.78
## + X3.Hydroxyphenylacetic.acid 1 0.096 495.25 295.79
## + UA..uM. 1 0.094 495.25 295.79
## + X4.Hydroxyphenylpropionate 1 0.091 495.25 295.79
## + Oleoylethanolamide 1 0.087 495.26 295.80
## + Dopa 1 0.065 495.28 295.81
## + BASO.... 1 0.065 495.28 295.81
## + p.Cresol.glucuronide 1 0.054 495.29 295.82
## + WBC..10.9.L. 1 0.052 495.29 295.82
## + X4.Ethylphenyl.sulfate 1 0.023 495.32 295.83
## + S.gosine.1.phosphate_b 1 0.023 495.32 295.83
## + Dopamine 1 0.019 495.32 295.84
## + Biliverdin 1 0.010 495.33 295.84
## + Urea..mM. 1 0.006 495.34 295.84
## + Enterolactone 1 0.001 495.34 295.85
## + LDL.C..mM. 1 0.000 495.34 295.85
## - Cholesterol.sulfate 1 6.832 502.17 295.86
## - Salicylic.acid 1 7.497 502.84 296.25
## - Xanthurenic.acid 1 7.752 503.09 296.40
## - X3.Hydroxyanthranilic.acid 1 7.981 503.32 296.53
## - X3.Hydroxyhippuric.acid 1 8.114 503.46 296.61
## - p.Cresol.sulfate 1 8.320 503.66 296.73
## - Gamma.aminobutyric.acid 1 8.366 503.71 296.75
## - Kynurenic.acid 1 8.599 503.94 296.89
## - Octadecanamide 1 9.019 504.36 297.13
## - Indole.3.carboxaldehyde 1 9.200 504.54 297.24
## - S.ganine.1.phosphate_b 1 9.983 505.33 297.69
## - Oleamide 1 10.942 506.28 298.25
## - LYMPH.... 1 11.309 506.65 298.46
## - NEUT.... 1 12.037 507.38 298.88
## - Ascorbic.acid 1 13.392 508.73 299.66
## - AST..U.L. 1 14.285 509.63 300.18
## - Phenyl.sulfate 1 16.815 512.16 301.63
## - Acetylglycine 1 18.200 513.54 302.42
## - Pantothenol 1 19.596 514.94 303.22
## - X5.Aminopentanoic.acid 1 20.092 515.43 303.50
## - X3.Hydroxypropionic.acid 1 22.627 517.97 304.94
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.369 519.71 305.92
## - ALT..U.L. 1 25.295 520.64 306.44
## - X1.5.Anhydrosorbitol 1 27.216 522.56 307.52
## - Sphinganine 1 28.520 523.86 308.25
## - HDL.C..mM. 1 29.515 524.86 308.81
## - Palmitoylethanolamide 1 40.866 536.21 315.07
## - Indole.3.acrylic.acid 1 42.024 537.37 315.71
## - X3.Indolebutyric.acid 1 54.695 550.04 322.54
## - TG..mM. 1 81.062 576.40 336.25
##
## Step: AIC=292
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + Benzoic.acid +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Benzoic.acid 1 0.324 495.93 290.19
## - Stearoylethanolamide 1 0.519 496.12 290.31
## - Indole.3.propionic.acid 1 0.597 496.20 290.35
## - CHE..U.L. 1 0.622 496.23 290.37
## - X5.Methoxyindoleacetate 1 0.708 496.31 290.42
## - Spermine 1 0.712 496.32 290.42
## - Sphingosine.1.phosphate 1 0.753 496.36 290.45
## - Iodide 1 0.943 496.55 290.56
## - X4.Hydroxyphenyllactate 1 0.995 496.60 290.59
## - Spermidine 1 1.009 496.61 290.60
## - X3.Hydroxybenzoic.acid 1 1.049 496.65 290.62
## - Hippuric.acid 1 1.221 496.82 290.72
## - Cre..uM. 1 1.581 497.18 290.94
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.769 497.37 291.05
## - Phenol 1 1.876 497.48 291.11
## - ALB..g.L. 1 2.388 497.99 291.41
## - ALP..U.L. 1 2.451 498.05 291.45
## - Sphinganine.1.phosphate 1 2.581 498.18 291.52
## - Urocanic.acid 1 2.594 498.20 291.53
## - N8.Acetylspermidine 1 2.759 498.36 291.63
## - Indole.3.methyl.acetate 1 2.816 498.42 291.66
## - Bilirubin 1 3.105 498.71 291.83
## - TBA..uM. 1 3.290 498.89 291.94
## - N.Acetylcadaverine 1 3.319 498.92 291.96
## <none> 495.60 292.00
## - Acetylcholine 1 3.439 499.04 292.03
## - Homovanillic.acid.sulfate 1 3.938 499.54 292.32
## - EO.... 1 4.202 499.81 292.48
## - Bilirubin.1 1 4.316 499.92 292.54
## - Cinnamoylglycine 1 4.706 500.31 292.77
## - N.acetyl.aspartic.acid 1 4.859 500.46 292.86
## - Phenyllactate 1 5.116 500.72 293.01
## - X2.Hydroxy.Hippuric.Acid 1 5.135 500.74 293.02
## - T.BIL..uM. 1 5.778 501.38 293.40
## - Phenylethylamine 1 5.988 501.59 293.52
## - Indoxyl.sulfate 1 6.182 501.79 293.63
## - D.BIL..uM. 1 6.311 501.91 293.71
## - Phenylacetylglutamine.PAGln. 1 6.480 502.08 293.81
## - Imidazolepropionic.acid 1 6.546 502.15 293.85
## + Putrescine 1 0.261 495.34 293.85
## + p.Cresol 1 0.256 495.35 293.85
## + Υ.GT..U.L. 1 0.187 495.42 293.89
## + Palmitic.amide 1 0.168 495.44 293.90
## + X4.Hydroxybenzoic.acid 1 0.149 495.45 293.91
## + Phenylacetic.acid 1 0.130 495.47 293.93
## + TC..mM. 1 0.125 495.48 293.93
## + Oleoylethanolamide 1 0.122 495.48 293.93
## + Sphingosine 1 0.111 495.49 293.94
## + S.gosine.1.phosphate_b 1 0.111 495.49 293.94
## + UA..uM. 1 0.109 495.49 293.94
## + Dopa 1 0.090 495.51 293.95
## + X3.Hydroxyphenylacetic.acid 1 0.079 495.52 293.96
## + X4.Hydroxyphenylpropionate 1 0.074 495.53 293.96
## + BASO.... 1 0.059 495.54 293.97
## + Dopamine 1 0.055 495.55 293.97
## + p.Cresol.glucuronide 1 0.032 495.57 293.98
## + WBC..10.9.L. 1 0.028 495.58 293.99
## + X4.Ethylphenyl.sulfate 1 0.024 495.58 293.99
## + Biliverdin 1 0.011 495.59 294.00
## + Urea..mM. 1 0.008 495.60 294.00
## + LDL.C..mM. 1 0.000 495.60 294.00
## + Enterolactone 1 0.000 495.60 294.00
## - Cholesterol.sulfate 1 6.888 502.49 294.05
## - Salicylic.acid 1 7.585 503.19 294.45
## - X3.Hydroxyanthranilic.acid 1 7.820 503.42 294.59
## - Xanthurenic.acid 1 7.931 503.53 294.65
## - X3.Hydroxyhippuric.acid 1 8.260 503.86 294.84
## - p.Cresol.sulfate 1 8.461 504.07 294.96
## - Kynurenic.acid 1 8.551 504.15 295.01
## - Gamma.aminobutyric.acid 1 8.656 504.26 295.08
## - Octadecanamide 1 8.948 504.55 295.24
## - Indole.3.carboxaldehyde 1 9.910 505.51 295.80
## - S.ganine.1.phosphate_b 1 10.266 505.87 296.01
## - Oleamide 1 10.757 506.36 296.29
## - LYMPH.... 1 11.175 506.78 296.54
## - NEUT.... 1 11.923 507.53 296.97
## - Ascorbic.acid 1 13.222 508.83 297.72
## - AST..U.L. 1 14.230 509.83 298.30
## - Phenyl.sulfate 1 16.566 512.17 299.64
## - Acetylglycine 1 18.760 514.36 300.89
## - Pantothenol 1 19.458 515.06 301.29
## - X5.Aminopentanoic.acid 1 20.721 516.33 302.00
## - X3.Hydroxypropionic.acid 1 22.478 518.08 303.00
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.674 520.28 304.24
## - ALT..U.L. 1 25.226 520.83 304.55
## - X1.5.Anhydrosorbitol 1 27.377 522.98 305.76
## - Sphinganine 1 28.325 523.93 306.29
## - HDL.C..mM. 1 29.365 524.97 306.87
## - Palmitoylethanolamide 1 41.081 536.68 313.33
## - Indole.3.acrylic.acid 1 41.807 537.41 313.73
## - X3.Indolebutyric.acid 1 54.470 550.07 320.56
## - TG..mM. 1 81.128 576.73 334.42
##
## Step: AIC=290.19
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Stearoylethanolamide + Bilirubin +
## Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.propionic.acid +
## Indole.3.methyl.acetate + Sphinganine + Sphinganine.1.phosphate +
## X3.Indolebutyric.acid + Sphingosine.1.phosphate + X5.Methoxyindoleacetate +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Stearoylethanolamide 1 0.424 496.35 288.44
## - Indole.3.propionic.acid 1 0.562 496.49 288.53
## - CHE..U.L. 1 0.613 496.54 288.56
## - Sphingosine.1.phosphate 1 0.641 496.57 288.57
## - Spermine 1 0.697 496.62 288.60
## - X5.Methoxyindoleacetate 1 0.699 496.63 288.61
## - Iodide 1 0.933 496.86 288.74
## - X4.Hydroxyphenyllactate 1 0.962 496.89 288.76
## - Spermidine 1 1.127 497.05 288.86
## - X3.Hydroxybenzoic.acid 1 1.192 497.12 288.90
## - Hippuric.acid 1 1.215 497.14 288.91
## - Cre..uM. 1 1.555 497.48 289.11
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.736 497.66 289.22
## - Phenol 1 1.810 497.74 289.26
## - ALP..U.L. 1 2.355 498.28 289.58
## - ALB..g.L. 1 2.411 498.34 289.61
## - Urocanic.acid 1 2.433 498.36 289.63
## - Sphinganine.1.phosphate 1 2.585 498.51 289.72
## - Indole.3.methyl.acetate 1 2.722 498.65 289.80
## - N8.Acetylspermidine 1 2.873 498.80 289.89
## - Bilirubin 1 2.893 498.82 289.90
## - TBA..uM. 1 3.163 499.09 290.06
## - N.Acetylcadaverine 1 3.260 499.19 290.11
## <none> 495.93 290.19
## - Acetylcholine 1 3.510 499.44 290.26
## - Bilirubin.1 1 4.055 499.98 290.58
## - Homovanillic.acid.sulfate 1 4.271 500.20 290.71
## - EO.... 1 4.293 500.22 290.72
## - Cinnamoylglycine 1 4.504 500.43 290.84
## - X2.Hydroxy.Hippuric.Acid 1 4.936 500.86 291.10
## - N.acetyl.aspartic.acid 1 4.997 500.92 291.13
## - Phenyllactate 1 5.205 501.13 291.25
## - T.BIL..uM. 1 5.625 501.55 291.50
## - Phenylethylamine 1 5.975 501.90 291.70
## - D.BIL..uM. 1 6.138 502.07 291.80
## - Indoxyl.sulfate 1 6.222 502.15 291.85
## - Imidazolepropionic.acid 1 6.367 502.29 291.93
## + Benzoic.acid 1 0.324 495.60 292.00
## - Phenylacetylglutamine.PAGln. 1 6.512 502.44 292.02
## + p.Cresol 1 0.282 495.65 292.03
## + Putrescine 1 0.205 495.72 292.07
## + TC..mM. 1 0.167 495.76 292.09
## + Palmitic.amide 1 0.166 495.76 292.10
## + UA..uM. 1 0.156 495.77 292.10
## + Υ.GT..U.L. 1 0.154 495.77 292.10
## + Sphingosine 1 0.153 495.77 292.10
## + Dopa 1 0.117 495.81 292.12
## + X4.Hydroxybenzoic.acid 1 0.114 495.81 292.13
## + Phenylacetic.acid 1 0.107 495.82 292.13
## + X3.Hydroxyphenylacetic.acid 1 0.101 495.83 292.13
## + Oleoylethanolamide 1 0.083 495.84 292.14
## + S.gosine.1.phosphate_b 1 0.064 495.86 292.16
## + Dopamine 1 0.062 495.87 292.16
## + X4.Hydroxyphenylpropionate 1 0.061 495.87 292.16
## + BASO.... 1 0.046 495.88 292.17
## - Cholesterol.sulfate 1 6.779 502.71 292.17
## + Biliverdin 1 0.026 495.90 292.18
## + WBC..10.9.L. 1 0.021 495.91 292.18
## + p.Cresol.glucuronide 1 0.020 495.91 292.18
## + Urea..mM. 1 0.011 495.92 292.19
## + X4.Ethylphenyl.sulfate 1 0.005 495.92 292.19
## + Enterolactone 1 0.003 495.93 292.19
## + LDL.C..mM. 1 0.001 495.93 292.19
## - Salicylic.acid 1 7.359 503.29 292.51
## - Xanthurenic.acid 1 7.769 503.70 292.75
## - X3.Hydroxyanthranilic.acid 1 8.184 504.11 292.99
## - X3.Hydroxyhippuric.acid 1 8.443 504.37 293.14
## - p.Cresol.sulfate 1 8.613 504.54 293.24
## - Gamma.aminobutyric.acid 1 8.785 504.71 293.34
## - Kynurenic.acid 1 8.910 504.84 293.41
## - Octadecanamide 1 9.001 504.93 293.46
## - Indole.3.carboxaldehyde 1 9.925 505.85 294.00
## - S.ganine.1.phosphate_b 1 10.190 506.12 294.15
## - Oleamide 1 10.949 506.88 294.59
## - LYMPH.... 1 11.352 507.28 294.82
## - NEUT.... 1 12.041 507.97 295.22
## - Ascorbic.acid 1 13.297 509.22 295.95
## - AST..U.L. 1 14.542 510.47 296.66
## - Phenyl.sulfate 1 16.784 512.71 297.95
## - Acetylglycine 1 18.843 514.77 299.12
## - Pantothenol 1 19.190 515.12 299.32
## - X5.Aminopentanoic.acid 1 20.559 516.49 300.09
## - X3.Hydroxypropionic.acid 1 22.353 518.28 301.11
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.808 520.74 302.50
## - ALT..U.L. 1 25.401 521.33 302.83
## - X1.5.Anhydrosorbitol 1 27.337 523.26 303.91
## - Sphinganine 1 28.246 524.17 304.42
## - HDL.C..mM. 1 29.744 525.67 305.26
## - Palmitoylethanolamide 1 40.765 536.69 311.34
## - Indole.3.acrylic.acid 1 41.511 537.44 311.75
## - X3.Indolebutyric.acid 1 54.694 550.62 318.85
## - TG..mM. 1 82.091 578.02 333.07
##
## Step: AIC=288.44
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Sphingosine.1.phosphate + X5.Methoxyindoleacetate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + X1.5.Anhydrosorbitol +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - X5.Methoxyindoleacetate 1 0.487 496.84 286.73
## - Indole.3.propionic.acid 1 0.603 496.95 286.80
## - Sphingosine.1.phosphate 1 0.615 496.97 286.81
## - CHE..U.L. 1 0.615 496.97 286.81
## - Spermine 1 0.721 497.07 286.87
## - Spermidine 1 0.951 497.30 287.00
## - Iodide 1 0.975 497.33 287.02
## - Hippuric.acid 1 1.186 497.54 287.14
## - X4.Hydroxyphenyllactate 1 1.227 497.58 287.17
## - X3.Hydroxybenzoic.acid 1 1.324 497.67 287.22
## - Cre..uM. 1 1.429 497.78 287.29
## - Phenol 1 1.845 498.20 287.53
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.013 498.36 287.63
## - ALP..U.L. 1 2.365 498.72 287.84
## - Urocanic.acid 1 2.424 498.78 287.87
## - Sphinganine.1.phosphate 1 2.630 498.98 287.99
## - ALB..g.L. 1 2.774 499.13 288.08
## - Indole.3.methyl.acetate 1 2.788 499.14 288.08
## - TBA..uM. 1 2.972 499.32 288.19
## - Bilirubin 1 2.974 499.33 288.19
## - N8.Acetylspermidine 1 3.003 499.35 288.21
## - N.Acetylcadaverine 1 3.212 499.56 288.33
## - Acetylcholine 1 3.306 499.66 288.39
## <none> 496.35 288.44
## - EO.... 1 4.051 500.40 288.83
## - Homovanillic.acid.sulfate 1 4.193 500.54 288.91
## - Bilirubin.1 1 4.213 500.56 288.92
## - Cinnamoylglycine 1 4.551 500.90 289.12
## - N.acetyl.aspartic.acid 1 4.733 501.08 289.22
## - X2.Hydroxy.Hippuric.Acid 1 5.262 501.61 289.53
## - Phenyllactate 1 5.809 502.16 289.85
## - Imidazolepropionic.acid 1 5.962 502.31 289.94
## - T.BIL..uM. 1 6.328 502.68 290.16
## - Phenylethylamine 1 6.370 502.72 290.18
## + Stearoylethanolamide 1 0.424 495.93 290.19
## + p.Cresol 1 0.288 496.06 290.27
## + Benzoic.acid 1 0.229 496.12 290.31
## + Oleoylethanolamide 1 0.198 496.15 290.33
## + Putrescine 1 0.190 496.16 290.33
## + TC..mM. 1 0.188 496.16 290.33
## + Palmitic.amide 1 0.178 496.17 290.34
## + Sphingosine 1 0.166 496.18 290.35
## + Υ.GT..U.L. 1 0.164 496.19 290.35
## - Indoxyl.sulfate 1 6.667 503.02 290.35
## + UA..uM. 1 0.150 496.20 290.36
## + Dopa 1 0.129 496.22 290.37
## - Phenylacetylglutamine.PAGln. 1 6.696 503.05 290.37
## + X4.Hydroxybenzoic.acid 1 0.118 496.23 290.37
## + Phenylacetic.acid 1 0.103 496.25 290.38
## + X3.Hydroxyphenylacetic.acid 1 0.083 496.27 290.39
## + Dopamine 1 0.078 496.27 290.40
## + Biliverdin 1 0.069 496.28 290.40
## + BASO.... 1 0.058 496.29 290.41
## + X4.Hydroxyphenylpropionate 1 0.055 496.30 290.41
## + S.gosine.1.phosphate_b 1 0.040 496.31 290.42
## + Urea..mM. 1 0.023 496.33 290.43
## + p.Cresol.glucuronide 1 0.022 496.33 290.43
## + X4.Ethylphenyl.sulfate 1 0.017 496.33 290.43
## + WBC..10.9.L. 1 0.005 496.35 290.44
## + LDL.C..mM. 1 0.001 496.35 290.44
## + Enterolactone 1 0.001 496.35 290.44
## - Cholesterol.sulfate 1 6.871 503.22 290.47
## - D.BIL..uM. 1 6.972 503.32 290.53
## - Salicylic.acid 1 7.800 504.15 291.01
## - Xanthurenic.acid 1 7.852 504.20 291.04
## - X3.Hydroxyhippuric.acid 1 8.090 504.44 291.18
## - Gamma.aminobutyric.acid 1 8.547 504.90 291.45
## - p.Cresol.sulfate 1 8.849 505.20 291.62
## - Octadecanamide 1 9.018 505.37 291.72
## - Kynurenic.acid 1 9.527 505.88 292.01
## - S.ganine.1.phosphate_b 1 10.670 507.02 292.68
## - Oleamide 1 10.695 507.05 292.69
## - LYMPH.... 1 11.026 507.38 292.88
## - Indole.3.carboxaldehyde 1 11.081 507.43 292.91
## - NEUT.... 1 11.683 508.03 293.26
## - X3.Hydroxyanthranilic.acid 1 12.863 509.21 293.94
## - Ascorbic.acid 1 13.330 509.68 294.21
## - AST..U.L. 1 15.098 511.45 295.22
## - Phenyl.sulfate 1 16.729 513.08 296.16
## - Pantothenol 1 18.848 515.20 297.36
## - Acetylglycine 1 18.877 515.23 297.38
## - X5.Aminopentanoic.acid 1 20.160 516.51 298.11
## - X3.Hydroxypropionic.acid 1 23.690 520.04 300.10
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.393 520.74 300.50
## - ALT..U.L. 1 26.449 522.80 301.66
## - Sphinganine 1 27.879 524.23 302.46
## - X1.5.Anhydrosorbitol 1 28.586 524.94 302.85
## - HDL.C..mM. 1 30.124 526.48 303.71
## - Indole.3.acrylic.acid 1 41.118 537.47 309.76
## - X3.Indolebutyric.acid 1 54.280 550.63 316.85
## - Palmitoylethanolamide 1 57.074 553.43 318.33
## - TG..mM. 1 81.935 578.29 331.21
##
## Step: AIC=286.73
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Sphingosine.1.phosphate + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + X1.5.Anhydrosorbitol +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Sphingosine.1.phosphate 1 0.484 497.32 285.02
## - CHE..U.L. 1 0.619 497.46 285.10
## - Indole.3.propionic.acid 1 0.619 497.46 285.10
## - Spermine 1 0.795 497.63 285.20
## - Spermidine 1 0.854 497.69 285.23
## - Iodide 1 0.883 497.72 285.25
## - X4.Hydroxyphenyllactate 1 1.123 497.96 285.39
## - Cre..uM. 1 1.227 498.07 285.45
## - Hippuric.acid 1 1.356 498.19 285.53
## - X3.Hydroxybenzoic.acid 1 1.377 498.22 285.54
## - Phenol 1 1.987 498.83 285.90
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.255 499.09 286.06
## - Sphinganine.1.phosphate 1 2.481 499.32 286.19
## - Urocanic.acid 1 2.590 499.43 286.25
## - ALP..U.L. 1 2.597 499.44 286.26
## - ALB..g.L. 1 2.772 499.61 286.36
## - Indole.3.methyl.acetate 1 2.827 499.67 286.39
## - TBA..uM. 1 2.966 499.80 286.47
## - Acetylcholine 1 3.032 499.87 286.51
## - N8.Acetylspermidine 1 3.302 500.14 286.67
## - N.Acetylcadaverine 1 3.360 500.20 286.71
## - Bilirubin 1 3.362 500.20 286.71
## <none> 496.84 286.73
## - EO.... 1 3.902 500.74 287.02
## - Homovanillic.acid.sulfate 1 4.270 501.11 287.24
## - N.acetyl.aspartic.acid 1 4.486 501.32 287.37
## - Cinnamoylglycine 1 4.807 501.65 287.55
## - Bilirubin.1 1 4.893 501.73 287.60
## - X2.Hydroxy.Hippuric.Acid 1 5.091 501.93 287.72
## - Phenyllactate 1 5.624 502.46 288.03
## - Imidazolepropionic.acid 1 5.654 502.49 288.05
## - T.BIL..uM. 1 6.223 503.06 288.38
## + X5.Methoxyindoleacetate 1 0.487 496.35 288.44
## + p.Cresol 1 0.354 496.48 288.52
## + Oleoylethanolamide 1 0.326 496.51 288.54
## - Phenylacetylglutamine.PAGln. 1 6.511 503.35 288.55
## - Indoxyl.sulfate 1 6.540 503.38 288.56
## + Benzoic.acid 1 0.245 496.59 288.59
## + Stearoylethanolamide 1 0.212 496.63 288.61
## + Palmitic.amide 1 0.190 496.65 288.62
## + TC..mM. 1 0.171 496.67 288.63
## - D.BIL..uM. 1 6.656 503.49 288.63
## + Sphingosine 1 0.170 496.67 288.63
## + Υ.GT..U.L. 1 0.127 496.71 288.66
## + X3.Hydroxyphenylacetic.acid 1 0.125 496.71 288.66
## + UA..uM. 1 0.122 496.72 288.66
## + Putrescine 1 0.112 496.73 288.67
## + X4.Hydroxybenzoic.acid 1 0.096 496.74 288.67
## + Phenylacetic.acid 1 0.093 496.75 288.68
## + Dopamine 1 0.078 496.76 288.69
## + X4.Hydroxyphenylpropionate 1 0.067 496.77 288.69
## + BASO.... 1 0.059 496.78 288.70
## + Dopa 1 0.048 496.79 288.70
## + S.gosine.1.phosphate_b 1 0.037 496.80 288.71
## + Biliverdin 1 0.027 496.81 288.72
## + X4.Ethylphenyl.sulfate 1 0.019 496.82 288.72
## + p.Cresol.glucuronide 1 0.017 496.82 288.72
## + LDL.C..mM. 1 0.013 496.83 288.72
## + Urea..mM. 1 0.006 496.83 288.73
## + WBC..10.9.L. 1 0.006 496.83 288.73
## + Enterolactone 1 0.000 496.84 288.73
## - Phenylethylamine 1 6.851 503.69 288.74
## - Cholesterol.sulfate 1 7.117 503.96 288.90
## - Salicylic.acid 1 7.616 504.45 289.19
## - Octadecanamide 1 8.704 505.54 289.82
## - X3.Hydroxyhippuric.acid 1 8.748 505.59 289.85
## - Xanthurenic.acid 1 8.751 505.59 289.85
## - Gamma.aminobutyric.acid 1 8.830 505.67 289.89
## - p.Cresol.sulfate 1 9.067 505.91 290.03
## - Kynurenic.acid 1 9.543 506.38 290.31
## - S.ganine.1.phosphate_b 1 10.293 507.13 290.74
## - Oleamide 1 10.371 507.21 290.78
## - Indole.3.carboxaldehyde 1 10.853 507.69 291.06
## - LYMPH.... 1 10.891 507.73 291.08
## - NEUT.... 1 11.556 508.40 291.47
## - Ascorbic.acid 1 14.269 511.11 293.03
## - X3.Hydroxyanthranilic.acid 1 14.286 511.12 293.04
## - AST..U.L. 1 15.620 512.46 293.80
## - Phenyl.sulfate 1 16.682 513.52 294.41
## - Pantothenol 1 18.802 515.64 295.61
## - Acetylglycine 1 18.859 515.70 295.65
## - X5.Aminopentanoic.acid 1 19.837 516.68 296.20
## - X3.Hydroxypropionic.acid 1 24.147 520.99 298.64
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 25.024 521.86 299.13
## - Sphinganine 1 27.492 524.33 300.51
## - ALT..U.L. 1 28.638 525.48 301.15
## - X1.5.Anhydrosorbitol 1 29.562 526.40 301.67
## - HDL.C..mM. 1 30.454 527.29 302.16
## - Indole.3.acrylic.acid 1 41.335 538.17 308.15
## - Palmitoylethanolamide 1 57.526 554.36 316.83
## - X3.Indolebutyric.acid 1 57.742 554.58 316.95
## - TG..mM. 1 82.006 578.84 329.49
##
## Step: AIC=285.02
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.propionic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Indole.3.propionic.acid 1 0.490 497.81 283.31
## - CHE..U.L. 1 0.713 498.04 283.44
## - Spermidine 1 0.827 498.15 283.50
## - Spermine 1 0.877 498.20 283.53
## - Iodide 1 0.939 498.26 283.57
## - X4.Hydroxyphenyllactate 1 0.997 498.32 283.60
## - Cre..uM. 1 1.173 498.50 283.71
## - Hippuric.acid 1 1.323 498.65 283.80
## - X3.Hydroxybenzoic.acid 1 1.372 498.70 283.82
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 2.016 499.34 284.20
## - Phenol 1 2.162 499.48 284.29
## - Urocanic.acid 1 2.338 499.66 284.39
## - ALP..U.L. 1 2.344 499.67 284.39
## - Indole.3.methyl.acetate 1 2.584 499.91 284.54
## - TBA..uM. 1 2.743 500.07 284.63
## - ALB..g.L. 1 2.803 500.13 284.66
## - Acetylcholine 1 2.828 500.15 284.68
## - Sphinganine.1.phosphate 1 2.971 500.29 284.76
## - Bilirubin 1 3.292 500.61 284.95
## - N8.Acetylspermidine 1 3.329 500.65 284.97
## - N.Acetylcadaverine 1 3.335 500.66 284.98
## <none> 497.32 285.02
## - EO.... 1 3.689 501.01 285.18
## - Homovanillic.acid.sulfate 1 4.129 501.45 285.44
## - N.acetyl.aspartic.acid 1 4.276 501.60 285.52
## - Cinnamoylglycine 1 4.749 502.07 285.80
## - Bilirubin.1 1 4.860 502.18 285.87
## - X2.Hydroxy.Hippuric.Acid 1 4.927 502.25 285.90
## - Phenyllactate 1 5.587 502.91 286.29
## - T.BIL..uM. 1 5.941 503.26 286.50
## - D.BIL..uM. 1 6.290 503.61 286.70
## + Sphingosine.1.phosphate 1 0.484 496.84 286.73
## + Oleoylethanolamide 1 0.378 496.95 286.79
## + X5.Methoxyindoleacetate 1 0.356 496.97 286.81
## + p.Cresol 1 0.355 496.97 286.81
## + S.gosine.1.phosphate_b 1 0.310 497.01 286.83
## + Putrescine 1 0.252 497.07 286.87
## + Palmitic.amide 1 0.230 497.09 286.88
## + Stearoylethanolamide 1 0.218 497.10 286.89
## - Indoxyl.sulfate 1 6.640 503.96 286.90
## - Phenylacetylglutamine.PAGln. 1 6.643 503.97 286.90
## + X3.Hydroxyphenylacetic.acid 1 0.180 497.14 286.91
## + UA..uM. 1 0.163 497.16 286.92
## + Benzoic.acid 1 0.160 497.16 286.92
## + Υ.GT..U.L. 1 0.159 497.16 286.92
## + TC..mM. 1 0.134 497.19 286.94
## - Imidazolepropionic.acid 1 6.726 504.05 286.95
## + Phenylacetic.acid 1 0.106 497.22 286.95
## + Dopa 1 0.078 497.24 286.97
## + X4.Hydroxyphenylpropionate 1 0.074 497.25 286.97
## + X4.Hydroxybenzoic.acid 1 0.074 497.25 286.97
## + BASO.... 1 0.060 497.26 286.98
## + Dopamine 1 0.054 497.27 286.98
## + Sphingosine 1 0.050 497.27 286.99
## + p.Cresol.glucuronide 1 0.031 497.29 287.00
## + X4.Ethylphenyl.sulfate 1 0.029 497.29 287.00
## + WBC..10.9.L. 1 0.018 497.30 287.01
## + Biliverdin 1 0.016 497.31 287.01
## + Urea..mM. 1 0.010 497.31 287.01
## + LDL.C..mM. 1 0.009 497.31 287.01
## + Enterolactone 1 0.000 497.32 287.02
## - Phenylethylamine 1 7.035 504.36 287.13
## - Cholesterol.sulfate 1 7.082 504.40 287.16
## - Salicylic.acid 1 7.532 504.85 287.42
## - Octadecanamide 1 8.541 505.86 288.01
## - Gamma.aminobutyric.acid 1 8.658 505.98 288.07
## - X3.Hydroxyhippuric.acid 1 8.912 506.23 288.22
## - Kynurenic.acid 1 9.394 506.72 288.50
## - p.Cresol.sulfate 1 9.417 506.74 288.51
## - Xanthurenic.acid 1 9.536 506.86 288.58
## - S.ganine.1.phosphate_b 1 9.834 507.16 288.75
## - Oleamide 1 10.213 507.54 288.97
## - LYMPH.... 1 11.087 508.41 289.48
## - NEUT.... 1 11.641 508.96 289.80
## - Indole.3.carboxaldehyde 1 11.996 509.32 290.00
## - Ascorbic.acid 1 14.101 511.42 291.21
## - X3.Hydroxyanthranilic.acid 1 14.277 511.60 291.31
## - AST..U.L. 1 16.552 513.87 292.61
## - Phenyl.sulfate 1 16.904 514.23 292.81
## - Pantothenol 1 18.557 515.88 293.75
## - Acetylglycine 1 19.072 516.39 294.04
## - X5.Aminopentanoic.acid 1 20.802 518.13 295.02
## - X3.Hydroxypropionic.acid 1 24.834 522.16 297.29
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 25.032 522.36 297.41
## - Sphinganine 1 27.660 524.98 298.88
## - X1.5.Anhydrosorbitol 1 29.337 526.66 299.81
## - ALT..U.L. 1 29.690 527.01 300.01
## - HDL.C..mM. 1 30.411 527.73 300.41
## - Indole.3.acrylic.acid 1 43.274 540.60 307.46
## - Palmitoylethanolamide 1 57.068 554.39 314.85
## - X3.Indolebutyric.acid 1 57.908 555.23 315.29
## - TG..mM. 1 82.027 579.35 327.75
##
## Step: AIC=283.31
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## CHE..U.L. + NEUT.... + LYMPH.... + EO.... + Phenylethylamine +
## Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + Acetylcholine + Spermidine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Spermine + Phenol + X1.5.Anhydrosorbitol +
## X3.Hydroxybenzoic.acid + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - CHE..U.L. 1 0.646 498.46 281.68
## - Spermidine 1 0.797 498.61 281.77
## - Spermine 1 0.886 498.70 281.83
## - Iodide 1 0.992 498.81 281.89
## - X4.Hydroxyphenyllactate 1 1.023 498.84 281.91
## - Cre..uM. 1 1.165 498.98 281.99
## - Hippuric.acid 1 1.279 499.09 282.06
## - X3.Hydroxybenzoic.acid 1 1.321 499.13 282.08
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.846 499.66 282.39
## - Phenol 1 2.149 499.96 282.57
## - Urocanic.acid 1 2.319 500.13 282.67
## - ALP..U.L. 1 2.339 500.15 282.68
## - TBA..uM. 1 2.679 500.49 282.88
## - Acetylcholine 1 2.853 500.67 282.98
## - Sphinganine.1.phosphate 1 3.010 500.82 283.07
## - ALB..g.L. 1 3.182 501.00 283.17
## - N8.Acetylspermidine 1 3.397 501.21 283.30
## <none> 497.81 283.31
## - EO.... 1 3.530 501.34 283.38
## - Bilirubin 1 3.601 501.41 283.42
## - N.Acetylcadaverine 1 3.841 501.65 283.56
## - Homovanillic.acid.sulfate 1 4.055 501.87 283.68
## - N.acetyl.aspartic.acid 1 4.434 502.25 283.90
## - Cinnamoylglycine 1 4.684 502.50 284.05
## - X2.Hydroxy.Hippuric.Acid 1 4.769 502.58 284.10
## - Bilirubin.1 1 5.002 502.82 284.23
## - Phenyllactate 1 5.448 503.26 284.49
## - T.BIL..uM. 1 6.097 503.91 284.87
## + Indole.3.propionic.acid 1 0.490 497.32 285.02
## + Oleoylethanolamide 1 0.387 497.43 285.08
## + X5.Methoxyindoleacetate 1 0.384 497.43 285.08
## - D.BIL..uM. 1 6.480 504.29 285.09
## + Sphingosine.1.phosphate 1 0.355 497.46 285.10
## + p.Cresol 1 0.327 497.49 285.11
## + X3.Hydroxyphenylacetic.acid 1 0.256 497.56 285.15
## + S.gosine.1.phosphate_b 1 0.246 497.57 285.16
## + Stearoylethanolamide 1 0.241 497.57 285.16
## + Putrescine 1 0.214 497.60 285.18
## + Palmitic.amide 1 0.197 497.62 285.19
## + UA..uM. 1 0.187 497.63 285.20
## + X4.Hydroxyphenylpropionate 1 0.183 497.63 285.20
## + Benzoic.acid 1 0.144 497.67 285.22
## + TC..mM. 1 0.139 497.67 285.22
## + Phenylacetic.acid 1 0.116 497.70 285.24
## - Phenylacetylglutamine.PAGln. 1 6.753 504.57 285.25
## + X4.Hydroxybenzoic.acid 1 0.082 497.73 285.26
## + Υ.GT..U.L. 1 0.081 497.73 285.26
## + Sphingosine 1 0.080 497.73 285.26
## + Dopa 1 0.072 497.74 285.26
## + BASO.... 1 0.066 497.75 285.27
## + Dopamine 1 0.065 497.75 285.27
## + p.Cresol.glucuronide 1 0.045 497.77 285.28
## + X4.Ethylphenyl.sulfate 1 0.032 497.78 285.29
## + Biliverdin 1 0.031 497.78 285.29
## + WBC..10.9.L. 1 0.025 497.79 285.29
## + Urea..mM. 1 0.020 497.79 285.29
## + LDL.C..mM. 1 0.008 497.81 285.30
## + Enterolactone 1 0.001 497.81 285.30
## - Imidazolepropionic.acid 1 6.935 504.75 285.36
## - Phenylethylamine 1 6.961 504.77 285.37
## - Cholesterol.sulfate 1 7.025 504.84 285.41
## - Indoxyl.sulfate 1 7.170 504.98 285.50
## - Salicylic.acid 1 7.316 505.13 285.58
## - Octadecanamide 1 8.446 506.26 286.23
## - Gamma.aminobutyric.acid 1 8.844 506.66 286.47
## - X3.Hydroxyhippuric.acid 1 8.905 506.72 286.50
## - Kynurenic.acid 1 9.503 507.32 286.85
## - Xanthurenic.acid 1 9.528 507.34 286.86
## - p.Cresol.sulfate 1 9.623 507.44 286.92
## - S.ganine.1.phosphate_b 1 10.016 507.83 287.14
## - Oleamide 1 10.020 507.83 287.14
## - LYMPH.... 1 10.743 508.56 287.56
## - NEUT.... 1 11.387 509.20 287.93
## - Indole.3.carboxaldehyde 1 12.402 510.21 288.52
## - Ascorbic.acid 1 14.055 511.87 289.46
## - X3.Hydroxyanthranilic.acid 1 14.249 512.06 289.57
## - AST..U.L. 1 16.719 514.53 290.98
## - Phenyl.sulfate 1 16.785 514.60 291.02
## - Pantothenol 1 18.606 516.42 292.06
## - Acetylglycine 1 18.813 516.63 292.17
## - X5.Aminopentanoic.acid 1 21.274 519.09 293.57
## - X3.Hydroxypropionic.acid 1 24.607 522.42 295.44
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.948 522.76 295.63
## - Indole.3.methyl.acetate 1 25.480 523.29 295.93
## - Sphinganine 1 27.977 525.79 297.33
## - X1.5.Anhydrosorbitol 1 29.361 527.17 298.10
## - HDL.C..mM. 1 29.949 527.76 298.42
## - ALT..U.L. 1 30.231 528.04 298.58
## - Indole.3.acrylic.acid 1 46.188 544.00 307.30
## - Palmitoylethanolamide 1 56.649 554.46 312.88
## - X3.Indolebutyric.acid 1 57.850 555.66 313.52
## - TG..mM. 1 81.537 579.35 325.75
##
## Step: AIC=281.68
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## NEUT.... + LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## Spermidine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Spermine + Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Spermidine 1 0.623 499.08 280.05
## - Iodide 1 1.015 499.47 280.28
## - Cre..uM. 1 1.022 499.48 280.29
## - X3.Hydroxybenzoic.acid 1 1.031 499.49 280.29
## - X4.Hydroxyphenyllactate 1 1.070 499.53 280.31
## - Spermine 1 1.116 499.58 280.34
## - Hippuric.acid 1 1.276 499.73 280.43
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.727 500.19 280.70
## - Phenol 1 2.041 500.50 280.88
## - Urocanic.acid 1 2.340 500.80 281.06
## - TBA..uM. 1 2.546 501.00 281.18
## - Acetylcholine 1 2.566 501.02 281.19
## - ALP..U.L. 1 2.572 501.03 281.19
## - Sphinganine.1.phosphate 1 3.172 501.63 281.54
## <none> 498.46 281.68
## - ALB..g.L. 1 3.433 501.89 281.70
## - EO.... 1 3.634 502.09 281.81
## - N8.Acetylspermidine 1 3.645 502.10 281.82
## - Bilirubin 1 3.783 502.24 281.90
## - N.Acetylcadaverine 1 3.998 502.46 282.03
## - Homovanillic.acid.sulfate 1 4.107 502.57 282.09
## - N.acetyl.aspartic.acid 1 4.315 502.77 282.21
## - Cinnamoylglycine 1 4.654 503.11 282.41
## - X2.Hydroxy.Hippuric.Acid 1 4.965 503.42 282.59
## - Bilirubin.1 1 5.082 503.54 282.66
## - Phenyllactate 1 5.759 504.22 283.05
## - T.BIL..uM. 1 5.925 504.38 283.15
## - D.BIL..uM. 1 6.171 504.63 283.29
## + CHE..U.L. 1 0.646 497.81 283.31
## + p.Cresol 1 0.495 497.96 283.39
## - Phenylacetylglutamine.PAGln. 1 6.381 504.84 283.41
## + Sphingosine.1.phosphate 1 0.439 498.02 283.43
## + Indole.3.propionic.acid 1 0.423 498.04 283.44
## + X5.Methoxyindoleacetate 1 0.374 498.08 283.46
## - Cholesterol.sulfate 1 6.483 504.94 283.47
## + Oleoylethanolamide 1 0.340 498.12 283.48
## + X3.Hydroxyphenylacetic.acid 1 0.335 498.12 283.49
## + S.gosine.1.phosphate_b 1 0.327 498.13 283.49
## + Putrescine 1 0.280 498.18 283.52
## + UA..uM. 1 0.253 498.21 283.54
## + Stearoylethanolamide 1 0.241 498.22 283.54
## + X4.Hydroxyphenylpropionate 1 0.165 498.29 283.59
## + X4.Hydroxybenzoic.acid 1 0.158 498.30 283.59
## + TC..mM. 1 0.157 498.30 283.59
## + Palmitic.amide 1 0.152 498.31 283.60
## + Benzoic.acid 1 0.133 498.33 283.61
## + Dopamine 1 0.122 498.34 283.61
## + Phenylacetic.acid 1 0.119 498.34 283.61
## + LDL.C..mM. 1 0.093 498.37 283.63
## + Dopa 1 0.087 498.37 283.63
## + Sphingosine 1 0.072 498.39 283.64
## + BASO.... 1 0.058 498.40 283.65
## + WBC..10.9.L. 1 0.048 498.41 283.66
## + Υ.GT..U.L. 1 0.043 498.42 283.66
## + p.Cresol.glucuronide 1 0.033 498.43 283.67
## + X4.Ethylphenyl.sulfate 1 0.031 498.43 283.67
## + Biliverdin 1 0.020 498.44 283.67
## + Urea..mM. 1 0.016 498.44 283.68
## + Enterolactone 1 0.004 498.45 283.68
## - Indoxyl.sulfate 1 6.878 505.34 283.70
## - Phenylethylamine 1 7.082 505.54 283.82
## - Imidazolepropionic.acid 1 7.204 505.66 283.89
## - Salicylic.acid 1 7.587 506.05 284.11
## - Octadecanamide 1 8.539 507.00 284.66
## - X3.Hydroxyhippuric.acid 1 9.057 507.52 284.96
## - Kynurenic.acid 1 9.214 507.67 285.05
## - Gamma.aminobutyric.acid 1 9.271 507.73 285.08
## - p.Cresol.sulfate 1 9.617 508.08 285.28
## - Oleamide 1 9.774 508.23 285.37
## - Xanthurenic.acid 1 9.960 508.42 285.48
## - LYMPH.... 1 10.260 508.72 285.65
## - S.ganine.1.phosphate_b 1 10.742 509.20 285.93
## - NEUT.... 1 11.127 509.59 286.15
## - Indole.3.carboxaldehyde 1 12.990 511.45 287.22
## - Ascorbic.acid 1 14.459 512.92 288.06
## - X3.Hydroxyanthranilic.acid 1 14.646 513.10 288.17
## - Phenyl.sulfate 1 16.176 514.63 289.04
## - AST..U.L. 1 17.339 515.80 289.70
## - Acetylglycine 1 18.346 516.80 290.28
## - Pantothenol 1 18.361 516.82 290.28
## - X5.Aminopentanoic.acid 1 21.476 519.93 292.04
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.793 523.25 293.91
## - Indole.3.methyl.acetate 1 25.726 524.18 294.43
## - X3.Hydroxypropionic.acid 1 25.888 524.35 294.52
## - X1.5.Anhydrosorbitol 1 29.231 527.69 296.38
## - Sphinganine 1 29.560 528.02 296.57
## - HDL.C..mM. 1 29.728 528.19 296.66
## - ALT..U.L. 1 33.447 531.91 298.71
## - Indole.3.acrylic.acid 1 46.530 544.99 305.83
## - Palmitoylethanolamide 1 56.324 554.78 311.05
## - X3.Indolebutyric.acid 1 60.201 558.66 313.09
## - TG..mM. 1 82.948 581.41 324.79
##
## Step: AIC=280.05
## FBG..mM. ~ ALT..U.L. + AST..U.L. + Cre..uM. + ALB..g.L. + TG..mM. +
## HDL.C..mM. + ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. +
## NEUT.... + LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Cre..uM. 1 0.966 500.05 278.62
## - Iodide 1 0.973 500.06 278.62
## - X3.Hydroxybenzoic.acid 1 1.111 500.19 278.70
## - Hippuric.acid 1 1.162 500.24 278.73
## - X4.Hydroxyphenyllactate 1 1.269 500.35 278.80
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.557 500.64 278.96
## - Spermine 1 2.012 501.09 279.23
## - Acetylcholine 1 2.250 501.33 279.37
## - Phenol 1 2.259 501.34 279.37
## - Urocanic.acid 1 2.288 501.37 279.39
## - TBA..uM. 1 2.352 501.43 279.43
## - ALP..U.L. 1 2.524 501.61 279.53
## - Sphinganine.1.phosphate 1 2.919 502.00 279.76
## <none> 499.08 280.05
## - ALB..g.L. 1 3.527 502.61 280.11
## - EO.... 1 3.656 502.74 280.19
## - Homovanillic.acid.sulfate 1 3.846 502.93 280.30
## - N8.Acetylspermidine 1 3.853 502.93 280.30
## - Bilirubin 1 4.065 503.15 280.43
## - N.acetyl.aspartic.acid 1 4.096 503.18 280.45
## - N.Acetylcadaverine 1 4.537 503.62 280.70
## - Bilirubin.1 1 4.698 503.78 280.80
## - Cinnamoylglycine 1 4.989 504.07 280.97
## - X2.Hydroxy.Hippuric.Acid 1 5.261 504.34 281.12
## - Phenyllactate 1 5.648 504.73 281.35
## + Spermidine 1 0.623 498.46 281.68
## - Phenylacetylglutamine.PAGln. 1 6.314 505.40 281.73
## + CHE..U.L. 1 0.472 498.61 281.77
## + p.Cresol 1 0.433 498.65 281.80
## - Cholesterol.sulfate 1 6.441 505.52 281.81
## + Sphingosine.1.phosphate 1 0.408 498.67 281.81
## + Indole.3.propionic.acid 1 0.407 498.68 281.81
## + X3.Hydroxyphenylacetic.acid 1 0.394 498.69 281.82
## - T.BIL..uM. 1 6.515 505.60 281.85
## + Oleoylethanolamide 1 0.306 498.78 281.87
## + X5.Methoxyindoleacetate 1 0.305 498.78 281.87
## + Putrescine 1 0.294 498.79 281.88
## + S.gosine.1.phosphate_b 1 0.257 498.82 281.90
## + X4.Hydroxybenzoic.acid 1 0.211 498.87 281.93
## + UA..uM. 1 0.207 498.88 281.93
## + Benzoic.acid 1 0.207 498.88 281.93
## + Palmitic.amide 1 0.195 498.89 281.94
## + X4.Hydroxyphenylpropionate 1 0.187 498.89 281.94
## + TC..mM. 1 0.176 498.91 281.95
## + Dopa 1 0.151 498.93 281.96
## + Stearoylethanolamide 1 0.148 498.93 281.96
## + Dopamine 1 0.125 498.96 281.98
## + LDL.C..mM. 1 0.116 498.97 281.98
## + Phenylacetic.acid 1 0.109 498.97 281.99
## + Sphingosine 1 0.109 498.97 281.99
## + Biliverdin 1 0.095 498.99 282.00
## + BASO.... 1 0.067 499.02 282.01
## + WBC..10.9.L. 1 0.054 499.03 282.02
## + X4.Ethylphenyl.sulfate 1 0.033 499.05 282.03
## + Υ.GT..U.L. 1 0.021 499.06 282.04
## + Enterolactone 1 0.010 499.07 282.05
## + p.Cresol.glucuronide 1 0.005 499.08 282.05
## + Urea..mM. 1 0.002 499.08 282.05
## - Indoxyl.sulfate 1 7.004 506.09 282.13
## - Imidazolepropionic.acid 1 7.156 506.24 282.22
## - Phenylethylamine 1 7.320 506.40 282.32
## - D.BIL..uM. 1 7.389 506.47 282.36
## - Salicylic.acid 1 7.893 506.97 282.65
## - Octadecanamide 1 8.015 507.10 282.72
## - X3.Hydroxyhippuric.acid 1 8.821 507.90 283.18
## - Oleamide 1 9.172 508.25 283.39
## - Xanthurenic.acid 1 9.591 508.67 283.63
## - Gamma.aminobutyric.acid 1 9.809 508.89 283.75
## - Kynurenic.acid 1 9.865 508.95 283.79
## - p.Cresol.sulfate 1 9.930 509.01 283.82
## - LYMPH.... 1 9.966 509.05 283.84
## - S.ganine.1.phosphate_b 1 10.358 509.44 284.07
## - NEUT.... 1 10.766 509.85 284.30
## - Indole.3.carboxaldehyde 1 13.327 512.41 285.77
## - Ascorbic.acid 1 14.361 513.44 286.36
## - X3.Hydroxyanthranilic.acid 1 14.427 513.51 286.40
## - Phenyl.sulfate 1 15.951 515.03 287.27
## - Pantothenol 1 17.940 517.02 288.40
## - Acetylglycine 1 18.160 517.24 288.52
## - AST..U.L. 1 18.254 517.34 288.58
## - X5.Aminopentanoic.acid 1 21.258 520.34 290.27
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.195 523.28 291.92
## - Indole.3.methyl.acetate 1 25.380 524.46 292.58
## - X3.Hydroxypropionic.acid 1 25.524 524.61 292.66
## - Sphinganine 1 29.049 528.13 294.63
## - HDL.C..mM. 1 30.044 529.13 295.18
## - X1.5.Anhydrosorbitol 1 30.182 529.26 295.26
## - ALT..U.L. 1 34.680 533.76 297.73
## - Indole.3.acrylic.acid 1 45.935 545.02 303.85
## - Palmitoylethanolamide 1 55.701 554.78 309.05
## - X3.Indolebutyric.acid 1 59.761 558.84 311.19
## - TG..mM. 1 84.146 583.23 323.70
##
## Step: AIC=278.62
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine + Hippuric.acid
##
## Df Sum of Sq RSS AIC
## - Hippuric.acid 1 1.051 501.10 277.23
## - X3.Hydroxybenzoic.acid 1 1.057 501.11 277.24
## - Iodide 1 1.150 501.20 277.29
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.422 501.47 277.45
## - X4.Hydroxyphenyllactate 1 2.011 502.06 277.79
## - Phenol 1 2.078 502.13 277.83
## - Spermine 1 2.182 502.23 277.89
## - Acetylcholine 1 2.192 502.24 277.90
## - ALP..U.L. 1 2.361 502.41 278.00
## - TBA..uM. 1 2.447 502.50 278.05
## - Urocanic.acid 1 2.688 502.74 278.19
## - Sphinganine.1.phosphate 1 2.738 502.79 278.22
## - N.acetyl.aspartic.acid 1 3.236 503.28 278.51
## - EO.... 1 3.417 503.47 278.61
## <none> 500.05 278.62
## - N8.Acetylspermidine 1 3.514 503.56 278.67
## - ALB..g.L. 1 3.717 503.76 278.79
## - Homovanillic.acid.sulfate 1 4.029 504.08 278.97
## - Bilirubin 1 4.325 504.37 279.14
## - X2.Hydroxy.Hippuric.Acid 1 5.079 505.13 279.58
## - Bilirubin.1 1 5.223 505.27 279.66
## - Phenyllactate 1 5.540 505.59 279.85
## - Cinnamoylglycine 1 5.772 505.82 279.98
## + Cre..uM. 1 0.966 499.08 280.05
## - N.Acetylcadaverine 1 6.029 506.08 280.13
## + Spermidine 1 0.567 499.48 280.29
## - Phenylacetylglutamine.PAGln. 1 6.319 506.37 280.30
## + Indole.3.propionic.acid 1 0.408 499.64 280.38
## + p.Cresol 1 0.390 499.66 280.39
## + CHE..U.L. 1 0.362 499.69 280.41
## + Sphingosine.1.phosphate 1 0.356 499.69 280.41
## + X4.Hydroxybenzoic.acid 1 0.340 499.71 280.42
## + Oleoylethanolamide 1 0.333 499.72 280.42
## + Dopa 1 0.288 499.76 280.45
## + Palmitic.amide 1 0.264 499.78 280.46
## + X3.Hydroxyphenylacetic.acid 1 0.258 499.79 280.47
## + TC..mM. 1 0.225 499.82 280.49
## - Cholesterol.sulfate 1 6.657 506.70 280.49
## + X4.Hydroxyphenylpropionate 1 0.200 499.85 280.50
## + Benzoic.acid 1 0.200 499.85 280.50
## + Putrescine 1 0.178 499.87 280.51
## + X5.Methoxyindoleacetate 1 0.174 499.87 280.52
## - Imidazolepropionic.acid 1 6.719 506.77 280.53
## + Biliverdin 1 0.151 499.90 280.53
## + Dopamine 1 0.142 499.91 280.53
## + Stearoylethanolamide 1 0.116 499.93 280.55
## + S.gosine.1.phosphate_b 1 0.106 499.94 280.56
## + Urea..mM. 1 0.071 499.98 280.58
## + BASO.... 1 0.068 499.98 280.58
## + Phenylacetic.acid 1 0.054 499.99 280.59
## + Sphingosine 1 0.049 500.00 280.59
## + X4.Ethylphenyl.sulfate 1 0.046 500.00 280.59
## + WBC..10.9.L. 1 0.020 500.03 280.61
## + Υ.GT..U.L. 1 0.013 500.03 280.61
## + LDL.C..mM. 1 0.009 500.04 280.61
## + UA..uM. 1 0.008 500.04 280.61
## + p.Cresol.glucuronide 1 0.005 500.04 280.61
## + Enterolactone 1 0.001 500.05 280.62
## - Phenylethylamine 1 6.972 507.02 280.67
## - T.BIL..uM. 1 7.059 507.11 280.72
## - D.BIL..uM. 1 7.466 507.51 280.96
## - Salicylic.acid 1 7.734 507.78 281.11
## - Octadecanamide 1 7.924 507.97 281.22
## - Indoxyl.sulfate 1 8.007 508.06 281.27
## - X3.Hydroxyhippuric.acid 1 8.709 508.76 281.68
## - Oleamide 1 8.715 508.76 281.68
## - Xanthurenic.acid 1 9.370 509.42 282.06
## - LYMPH.... 1 9.566 509.61 282.17
## - Gamma.aminobutyric.acid 1 9.799 509.85 282.30
## - p.Cresol.sulfate 1 9.889 509.94 282.36
## - S.ganine.1.phosphate_b 1 9.998 510.05 282.42
## - NEUT.... 1 10.679 510.73 282.81
## - Kynurenic.acid 1 13.316 513.36 284.32
## - Indole.3.carboxaldehyde 1 13.653 513.70 284.51
## - Ascorbic.acid 1 14.444 514.49 284.96
## - X3.Hydroxyanthranilic.acid 1 14.939 514.99 285.24
## - Phenyl.sulfate 1 15.653 515.70 285.65
## - AST..U.L. 1 17.766 517.81 286.85
## - Pantothenol 1 18.212 518.26 287.10
## - Acetylglycine 1 19.232 519.28 287.67
## - X5.Aminopentanoic.acid 1 20.954 521.00 288.65
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.295 524.34 290.52
## - X3.Hydroxypropionic.acid 1 25.811 525.86 291.36
## - Indole.3.methyl.acetate 1 26.522 526.57 291.76
## - Sphinganine 1 28.926 528.97 293.09
## - X1.5.Anhydrosorbitol 1 30.057 530.11 293.72
## - HDL.C..mM. 1 30.316 530.36 293.86
## - ALT..U.L. 1 34.963 535.01 296.42
## - Indole.3.acrylic.acid 1 46.886 546.93 302.88
## - Palmitoylethanolamide 1 55.702 555.75 307.56
## - X3.Indolebutyric.acid 1 59.950 560.00 309.79
## - TG..mM. 1 83.835 583.88 322.03
##
## Step: AIC=277.23
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + X3.Hydroxybenzoic.acid +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - X3.Hydroxybenzoic.acid 1 1.017 502.12 275.83
## - Iodide 1 1.143 502.24 275.90
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.811 502.91 276.29
## - X4.Hydroxyphenyllactate 1 1.928 503.03 276.36
## - Spermine 1 2.113 503.21 276.47
## - Acetylcholine 1 2.248 503.35 276.54
## - Phenol 1 2.298 503.40 276.57
## - ALP..U.L. 1 2.330 503.43 276.59
## - TBA..uM. 1 2.414 503.51 276.64
## - Urocanic.acid 1 2.650 503.75 276.78
## - EO.... 1 3.206 504.30 277.10
## - N.acetyl.aspartic.acid 1 3.269 504.37 277.14
## - Sphinganine.1.phosphate 1 3.403 504.50 277.22
## <none> 501.10 277.23
## - N8.Acetylspermidine 1 3.555 504.65 277.30
## - ALB..g.L. 1 3.763 504.86 277.42
## - Homovanillic.acid.sulfate 1 3.846 504.94 277.47
## - Bilirubin 1 4.785 505.88 278.02
## - Cinnamoylglycine 1 4.840 505.94 278.05
## - X2.Hydroxy.Hippuric.Acid 1 5.146 506.24 278.23
## - Bilirubin.1 1 5.672 506.77 278.53
## + Hippuric.acid 1 1.051 500.05 278.62
## - Phenyllactate 1 5.934 507.03 278.68
## + Cre..uM. 1 0.855 500.24 278.73
## - N.Acetylcadaverine 1 6.169 507.27 278.82
## - Phenylacetylglutamine.PAGln. 1 6.378 507.48 278.94
## + Spermidine 1 0.466 500.63 278.96
## + X4.Hydroxybenzoic.acid 1 0.386 500.71 279.01
## + CHE..U.L. 1 0.377 500.72 279.01
## + Indole.3.propionic.acid 1 0.373 500.73 279.01
## + X4.Hydroxyphenylpropionate 1 0.354 500.74 279.03
## + Sphingosine.1.phosphate 1 0.340 500.76 279.03
## + Oleoylethanolamide 1 0.330 500.77 279.04
## + X5.Methoxyindoleacetate 1 0.280 500.82 279.07
## + X3.Hydroxyphenylacetic.acid 1 0.270 500.83 279.07
## + TC..mM. 1 0.248 500.85 279.09
## + Palmitic.amide 1 0.231 500.87 279.10
## + p.Cresol 1 0.221 500.88 279.10
## + Benzoic.acid 1 0.196 500.90 279.12
## + Dopamine 1 0.165 500.93 279.14
## + S.gosine.1.phosphate_b 1 0.125 500.97 279.16
## + Dopa 1 0.118 500.98 279.16
## - Cholesterol.sulfate 1 6.772 507.87 279.17
## + Biliverdin 1 0.108 500.99 279.17
## + Putrescine 1 0.099 501.00 279.17
## + Stearoylethanolamide 1 0.093 501.01 279.18
## + X4.Ethylphenyl.sulfate 1 0.080 501.02 279.19
## + BASO.... 1 0.067 501.03 279.19
## + Sphingosine 1 0.058 501.04 279.20
## + Urea..mM. 1 0.042 501.06 279.21
## + Phenylacetic.acid 1 0.042 501.06 279.21
## + UA..uM. 1 0.023 501.08 279.22
## + p.Cresol.glucuronide 1 0.023 501.08 279.22
## + WBC..10.9.L. 1 0.013 501.09 279.23
## + LDL.C..mM. 1 0.009 501.09 279.23
## + Υ.GT..U.L. 1 0.006 501.09 279.23
## + Enterolactone 1 0.003 501.10 279.23
## - Imidazolepropionic.acid 1 6.900 508.00 279.24
## - Phenylethylamine 1 7.487 508.59 279.58
## - T.BIL..uM. 1 7.520 508.62 279.60
## - Salicylic.acid 1 7.838 508.94 279.78
## - D.BIL..uM. 1 7.969 509.07 279.86
## - Octadecanamide 1 8.040 509.14 279.90
## - Indoxyl.sulfate 1 8.225 509.32 280.00
## - Oleamide 1 8.477 509.58 280.15
## - X3.Hydroxyhippuric.acid 1 9.037 510.14 280.47
## - LYMPH.... 1 9.118 510.22 280.52
## - Gamma.aminobutyric.acid 1 9.716 510.81 280.86
## - Xanthurenic.acid 1 9.810 510.91 280.91
## - NEUT.... 1 10.150 511.25 281.11
## - p.Cresol.sulfate 1 10.810 511.91 281.49
## - S.ganine.1.phosphate_b 1 11.408 512.51 281.83
## - Indole.3.carboxaldehyde 1 13.041 514.14 282.76
## - Kynurenic.acid 1 14.226 515.33 283.44
## - Ascorbic.acid 1 14.691 515.79 283.70
## - Phenyl.sulfate 1 15.309 516.41 284.05
## - X3.Hydroxyanthranilic.acid 1 15.724 516.82 284.29
## - AST..U.L. 1 18.086 519.19 285.62
## - Acetylglycine 1 18.618 519.72 285.92
## - Pantothenol 1 19.542 520.64 286.44
## - X5.Aminopentanoic.acid 1 21.227 522.33 287.39
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.467 524.57 288.64
## - X3.Hydroxypropionic.acid 1 25.935 527.03 290.02
## - Indole.3.methyl.acetate 1 26.277 527.38 290.21
## - Sphinganine 1 29.071 530.17 291.76
## - X1.5.Anhydrosorbitol 1 29.908 531.01 292.22
## - HDL.C..mM. 1 30.719 531.82 292.67
## - ALT..U.L. 1 35.258 536.36 295.16
## - Indole.3.acrylic.acid 1 46.344 547.44 301.15
## - Palmitoylethanolamide 1 54.651 555.75 305.56
## - X3.Indolebutyric.acid 1 60.818 561.92 308.80
## - TG..mM. 1 83.136 584.23 320.21
##
## Step: AIC=275.83
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Iodide + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - Iodide 1 1.011 503.13 274.42
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.644 503.76 274.78
## - X4.Hydroxyphenyllactate 1 1.940 504.06 274.96
## - Spermine 1 2.076 504.19 275.04
## - TBA..uM. 1 2.121 504.24 275.06
## - ALP..U.L. 1 2.146 504.26 275.08
## - Phenol 1 2.396 504.51 275.22
## - Acetylcholine 1 2.625 504.74 275.35
## - Urocanic.acid 1 2.717 504.83 275.41
## - EO.... 1 3.351 505.47 275.78
## <none> 502.12 275.83
## - N.acetyl.aspartic.acid 1 3.547 505.66 275.89
## - Sphinganine.1.phosphate 1 3.603 505.72 275.92
## - N8.Acetylspermidine 1 3.719 505.83 275.99
## - Homovanillic.acid.sulfate 1 3.764 505.88 276.02
## - ALB..g.L. 1 4.012 506.13 276.16
## - Bilirubin 1 4.651 506.77 276.53
## - X2.Hydroxy.Hippuric.Acid 1 5.328 507.44 276.92
## - Cinnamoylglycine 1 5.612 507.73 277.08
## - Bilirubin.1 1 5.794 507.91 277.19
## + X3.Hydroxybenzoic.acid 1 1.017 501.10 277.23
## + Hippuric.acid 1 1.011 501.11 277.24
## - Phenyllactate 1 6.049 508.16 277.34
## + Cre..uM. 1 0.807 501.31 277.36
## + X3.Hydroxyphenylacetic.acid 1 0.586 501.53 277.48
## + Spermidine 1 0.536 501.58 277.51
## - Phenylacetylglutamine.PAGln. 1 6.404 508.52 277.54
## - Cholesterol.sulfate 1 6.420 508.54 277.55
## + Oleoylethanolamide 1 0.474 501.64 277.55
## + X4.Hydroxybenzoic.acid 1 0.375 501.74 277.61
## + Indole.3.propionic.acid 1 0.347 501.77 277.62
## + Sphingosine.1.phosphate 1 0.323 501.79 277.64
## + X5.Methoxyindoleacetate 1 0.314 501.80 277.64
## + Benzoic.acid 1 0.302 501.81 277.65
## + X4.Hydroxyphenylpropionate 1 0.276 501.84 277.67
## + p.Cresol 1 0.240 501.88 277.69
## + Palmitic.amide 1 0.229 501.89 277.69
## + Biliverdin 1 0.191 501.92 277.72
## + Dopa 1 0.182 501.93 277.72
## + TC..mM. 1 0.178 501.94 277.72
## + CHE..U.L. 1 0.167 501.95 277.73
## + Stearoylethanolamide 1 0.140 501.98 277.75
## + Sphingosine 1 0.124 501.99 277.75
## + BASO.... 1 0.119 502.00 277.76
## + Putrescine 1 0.119 502.00 277.76
## + S.gosine.1.phosphate_b 1 0.118 502.00 277.76
## - Imidazolepropionic.acid 1 6.801 508.92 277.77
## + X4.Ethylphenyl.sulfate 1 0.089 502.03 277.77
## + Urea..mM. 1 0.067 502.05 277.79
## + Dopamine 1 0.063 502.05 277.79
## + Υ.GT..U.L. 1 0.030 502.09 277.81
## + UA..uM. 1 0.027 502.09 277.81
## + Phenylacetic.acid 1 0.016 502.10 277.82
## + LDL.C..mM. 1 0.014 502.10 277.82
## + WBC..10.9.L. 1 0.004 502.11 277.82
## + Enterolactone 1 0.001 502.12 277.83
## + p.Cresol.glucuronide 1 0.000 502.12 277.83
## - N.Acetylcadaverine 1 7.057 509.17 277.92
## - T.BIL..uM. 1 7.267 509.38 278.04
## - Phenylethylamine 1 7.636 509.75 278.25
## - D.BIL..uM. 1 7.643 509.76 278.25
## - Octadecanamide 1 7.728 509.84 278.30
## - Salicylic.acid 1 8.028 510.14 278.47
## - Indoxyl.sulfate 1 8.129 510.24 278.53
## - Oleamide 1 8.334 510.45 278.65
## - Gamma.aminobutyric.acid 1 8.919 511.03 278.99
## - LYMPH.... 1 9.333 511.45 279.22
## - X3.Hydroxyhippuric.acid 1 9.391 511.51 279.26
## - NEUT.... 1 10.037 512.15 279.63
## - Xanthurenic.acid 1 10.057 512.17 279.64
## - p.Cresol.sulfate 1 11.523 513.64 280.48
## - S.ganine.1.phosphate_b 1 12.134 514.25 280.82
## - Indole.3.carboxaldehyde 1 13.209 515.32 281.43
## - Kynurenic.acid 1 14.384 516.50 282.10
## - Ascorbic.acid 1 14.441 516.56 282.13
## - Phenyl.sulfate 1 15.253 517.37 282.60
## - X3.Hydroxyanthranilic.acid 1 16.395 518.51 283.24
## - AST..U.L. 1 17.908 520.02 284.09
## - Pantothenol 1 19.854 521.97 285.19
## - X5.Aminopentanoic.acid 1 20.952 523.07 285.80
## - Acetylglycine 1 21.246 523.36 285.97
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.769 525.88 287.38
## - Indole.3.methyl.acetate 1 25.691 527.81 288.45
## - X3.Hydroxypropionic.acid 1 26.796 528.91 289.06
## - Sphinganine 1 28.740 530.86 290.14
## - X1.5.Anhydrosorbitol 1 29.332 531.45 290.46
## - HDL.C..mM. 1 30.481 532.60 291.09
## - ALT..U.L. 1 35.135 537.25 293.64
## - Indole.3.acrylic.acid 1 45.676 547.79 299.34
## - Palmitoylethanolamide 1 55.075 557.19 304.32
## - X3.Indolebutyric.acid 1 60.408 562.52 307.11
## - TG..mM. 1 82.134 584.25 318.22
##
## Step: AIC=274.42
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Phenyl.sulfate + X4.Hydroxybenzoic.acid.4.O.sulphate +
## X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.631 504.76 273.36
## - X4.Hydroxyphenyllactate 1 1.841 504.97 273.49
## - Spermine 1 1.861 504.99 273.50
## - ALP..U.L. 1 2.205 505.33 273.70
## - Phenol 1 2.377 505.50 273.80
## - Acetylcholine 1 2.465 505.59 273.85
## - TBA..uM. 1 2.476 505.60 273.85
## - Urocanic.acid 1 2.930 506.06 274.12
## - Sphinganine.1.phosphate 1 3.291 506.42 274.33
## <none> 503.13 274.42
## - EO.... 1 3.488 506.62 274.44
## - N.acetyl.aspartic.acid 1 3.693 506.82 274.56
## - N8.Acetylspermidine 1 4.050 507.18 274.77
## - Homovanillic.acid.sulfate 1 4.143 507.27 274.82
## - Bilirubin 1 4.401 507.53 274.97
## - ALB..g.L. 1 4.480 507.61 275.01
## - X2.Hydroxy.Hippuric.Acid 1 5.489 508.62 275.60
## - Bilirubin.1 1 5.773 508.90 275.76
## - Cinnamoylglycine 1 5.855 508.98 275.81
## + Iodide 1 1.011 502.12 275.83
## + Hippuric.acid 1 1.006 502.12 275.83
## + Cre..uM. 1 0.963 502.16 275.86
## + X3.Hydroxybenzoic.acid 1 0.886 502.24 275.90
## - Phenyllactate 1 6.032 509.16 275.91
## + X3.Hydroxyphenylacetic.acid 1 0.557 502.57 276.09
## + Spermidine 1 0.488 502.64 276.13
## - Imidazolepropionic.acid 1 6.425 509.55 276.13
## - Phenylacetylglutamine.PAGln. 1 6.428 509.55 276.14
## + X4.Hydroxybenzoic.acid 1 0.465 502.66 276.15
## + Indole.3.propionic.acid 1 0.395 502.73 276.19
## + Sphingosine.1.phosphate 1 0.363 502.76 276.20
## + X4.Hydroxyphenylpropionate 1 0.309 502.82 276.24
## + Oleoylethanolamide 1 0.309 502.82 276.24
## - N.Acetylcadaverine 1 6.612 509.74 276.24
## + Benzoic.acid 1 0.267 502.86 276.26
## + p.Cresol 1 0.256 502.87 276.27
## + X5.Methoxyindoleacetate 1 0.223 502.90 276.29
## + Biliverdin 1 0.188 502.94 276.31
## + CHE..U.L. 1 0.186 502.94 276.31
## + Stearoylethanolamide 1 0.176 502.95 276.31
## + Urea..mM. 1 0.174 502.95 276.32
## + Dopa 1 0.174 502.95 276.32
## + Palmitic.amide 1 0.171 502.96 276.32
## + Putrescine 1 0.165 502.96 276.32
## + S.gosine.1.phosphate_b 1 0.155 502.97 276.33
## + TC..mM. 1 0.135 502.99 276.34
## + BASO.... 1 0.126 503.00 276.34
## + Dopamine 1 0.100 503.03 276.36
## + Sphingosine 1 0.086 503.04 276.37
## + Υ.GT..U.L. 1 0.035 503.09 276.40
## + X4.Ethylphenyl.sulfate 1 0.032 503.10 276.40
## + LDL.C..mM. 1 0.021 503.11 276.40
## + Phenylacetic.acid 1 0.020 503.11 276.40
## + UA..uM. 1 0.008 503.12 276.41
## + WBC..10.9.L. 1 0.005 503.12 276.41
## + p.Cresol.glucuronide 1 0.003 503.12 276.41
## + Enterolactone 1 0.001 503.13 276.42
## - Cholesterol.sulfate 1 7.048 510.18 276.49
## - T.BIL..uM. 1 7.650 510.78 276.84
## - Phenylethylamine 1 7.914 511.04 276.99
## - D.BIL..uM. 1 8.048 511.18 277.07
## - Salicylic.acid 1 8.437 511.56 277.29
## - Octadecanamide 1 8.518 511.64 277.34
## - Indoxyl.sulfate 1 9.022 512.15 277.62
## - LYMPH.... 1 9.090 512.22 277.66
## - Oleamide 1 9.091 512.22 277.66
## - Gamma.aminobutyric.acid 1 9.216 512.34 277.74
## - X3.Hydroxyhippuric.acid 1 9.367 512.49 277.82
## - Xanthurenic.acid 1 9.551 512.68 277.93
## - NEUT.... 1 9.893 513.02 278.12
## - p.Cresol.sulfate 1 11.265 514.39 278.90
## - S.ganine.1.phosphate_b 1 11.713 514.84 279.16
## - Ascorbic.acid 1 13.859 516.99 280.38
## - Indole.3.carboxaldehyde 1 14.625 517.75 280.81
## - Phenyl.sulfate 1 14.929 518.06 280.98
## - Kynurenic.acid 1 15.157 518.28 281.11
## - X3.Hydroxyanthranilic.acid 1 16.125 519.25 281.66
## - AST..U.L. 1 19.055 522.18 283.31
## - Pantothenol 1 19.543 522.67 283.58
## - X5.Aminopentanoic.acid 1 21.179 524.31 284.50
## - Acetylglycine 1 22.151 525.28 285.04
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.214 526.34 285.63
## - X3.Hydroxypropionic.acid 1 25.835 528.96 287.09
## - Indole.3.methyl.acetate 1 26.979 530.11 287.72
## - Sphinganine 1 28.336 531.46 288.47
## - X1.5.Anhydrosorbitol 1 29.269 532.40 288.98
## - HDL.C..mM. 1 33.550 536.68 291.33
## - ALT..U.L. 1 37.612 540.74 293.54
## - Indole.3.acrylic.acid 1 47.984 551.11 299.11
## - Palmitoylethanolamide 1 54.554 557.68 302.58
## - X3.Indolebutyric.acid 1 60.392 563.52 305.63
## - TG..mM. 1 85.954 589.08 318.63
##
## Step: AIC=273.36
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## X4.Hydroxyphenyllactate + p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid +
## X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b + Cholesterol.sulfate +
## Xanthurenic.acid + Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid +
## Homovanillic.acid.sulfate + Phenyl.sulfate + X3.Hydroxypropionic.acid +
## Acetylglycine
##
## Df Sum of Sq RSS AIC
## - X4.Hydroxyphenyllactate 1 1.190 505.95 272.05
## - Spermine 1 1.533 506.29 272.25
## - ALP..U.L. 1 1.913 506.67 272.47
## - Acetylcholine 1 2.084 506.84 272.57
## - TBA..uM. 1 2.210 506.97 272.64
## - Phenol 1 2.791 507.55 272.98
## - Urocanic.acid 1 2.899 507.66 273.04
## - N.acetyl.aspartic.acid 1 3.336 508.09 273.29
## - EO.... 1 3.358 508.12 273.31
## <none> 504.76 273.36
## - Sphinganine.1.phosphate 1 3.555 508.31 273.42
## - Homovanillic.acid.sulfate 1 3.719 508.48 273.52
## - Bilirubin 1 4.205 508.96 273.80
## - N8.Acetylspermidine 1 4.449 509.21 273.94
## - Phenyllactate 1 4.631 509.39 274.04
## - ALB..g.L. 1 5.188 509.95 274.36
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 1.631 503.13 274.42
## - X2.Hydroxy.Hippuric.Acid 1 5.532 510.29 274.56
## + Hippuric.acid 1 1.370 503.39 274.57
## + Iodide 1 0.998 503.76 274.78
## - Cinnamoylglycine 1 6.047 510.80 274.85
## + Cre..uM. 1 0.802 503.96 274.90
## - Cholesterol.sulfate 1 6.182 510.94 274.93
## + X3.Hydroxybenzoic.acid 1 0.733 504.03 274.94
## + X3.Hydroxyphenylacetic.acid 1 0.615 504.14 275.01
## - Imidazolepropionic.acid 1 6.316 511.07 275.01
## + Oleoylethanolamide 1 0.446 504.31 275.11
## + X4.Hydroxybenzoic.acid 1 0.440 504.32 275.11
## + X5.Methoxyindoleacetate 1 0.433 504.32 275.11
## + X4.Hydroxyphenylpropionate 1 0.406 504.35 275.13
## + Biliverdin 1 0.402 504.36 275.13
## - Bilirubin.1 1 6.587 511.35 275.16
## + Spermidine 1 0.320 504.44 275.18
## + Stearoylethanolamide 1 0.310 504.45 275.18
## + Indole.3.propionic.acid 1 0.253 504.50 275.22
## + Benzoic.acid 1 0.223 504.53 275.23
## + Sphingosine.1.phosphate 1 0.191 504.57 275.25
## + CHE..U.L. 1 0.159 504.60 275.27
## + Dopamine 1 0.156 504.60 275.27
## + BASO.... 1 0.154 504.60 275.28
## + Sphingosine 1 0.143 504.61 275.28
## + Urea..mM. 1 0.143 504.61 275.28
## + TC..mM. 1 0.133 504.63 275.29
## + Palmitic.amide 1 0.113 504.64 275.30
## + X4.Ethylphenyl.sulfate 1 0.105 504.65 275.30
## + p.Cresol.glucuronide 1 0.090 504.67 275.31
## + Phenylacetic.acid 1 0.077 504.68 275.32
## + Dopa 1 0.061 504.70 275.33
## + S.gosine.1.phosphate_b 1 0.045 504.71 275.34
## + UA..uM. 1 0.029 504.73 275.35
## + WBC..10.9.L. 1 0.024 504.73 275.35
## + Enterolactone 1 0.018 504.74 275.35
## + p.Cresol 1 0.015 504.74 275.36
## + Putrescine 1 0.012 504.75 275.36
## + LDL.C..mM. 1 0.012 504.75 275.36
## + Υ.GT..U.L. 1 0.005 504.75 275.36
## - Phenylacetylglutamine.PAGln. 1 7.656 512.41 275.78
## - D.BIL..uM. 1 7.676 512.43 275.79
## - Octadecanamide 1 7.714 512.47 275.81
## - N.Acetylcadaverine 1 7.747 512.50 275.83
## - Oleamide 1 7.956 512.71 275.95
## - T.BIL..uM. 1 8.178 512.94 276.07
## - Salicylic.acid 1 8.582 513.34 276.30
## - Phenylethylamine 1 8.690 513.45 276.37
## - Xanthurenic.acid 1 8.997 513.75 276.54
## - X3.Hydroxyhippuric.acid 1 9.000 513.76 276.54
## - LYMPH.... 1 9.120 513.88 276.61
## - NEUT.... 1 9.843 514.60 277.02
## - Gamma.aminobutyric.acid 1 11.033 515.79 277.70
## - Indoxyl.sulfate 1 11.418 516.18 277.92
## - S.ganine.1.phosphate_b 1 12.348 517.11 278.45
## - p.Cresol.sulfate 1 12.914 517.67 278.77
## - Ascorbic.acid 1 14.995 519.75 279.94
## - Kynurenic.acid 1 15.279 520.04 280.10
## - Phenyl.sulfate 1 15.593 520.35 280.28
## - X3.Hydroxyanthranilic.acid 1 16.764 521.52 280.94
## - Indole.3.carboxaldehyde 1 16.821 521.58 280.97
## - Pantothenol 1 18.837 523.59 282.10
## - AST..U.L. 1 19.078 523.84 282.23
## - X5.Aminopentanoic.acid 1 20.700 525.46 283.14
## - Acetylglycine 1 22.496 527.25 284.14
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.764 527.52 284.29
## - X3.Hydroxypropionic.acid 1 26.326 531.08 286.26
## - Indole.3.methyl.acetate 1 27.363 532.12 286.83
## - X1.5.Anhydrosorbitol 1 30.106 534.86 288.34
## - Sphinganine 1 32.106 536.86 289.43
## - HDL.C..mM. 1 33.827 538.58 290.37
## - ALT..U.L. 1 36.974 541.73 292.08
## - Indole.3.acrylic.acid 1 48.917 553.67 298.47
## - Palmitoylethanolamide 1 56.026 560.78 302.20
## - X3.Indolebutyric.acid 1 60.837 565.59 304.71
## - TG..mM. 1 85.139 589.90 317.03
##
## Step: AIC=272.05
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Spermine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - Spermine 1 1.603 507.55 270.98
## - ALP..U.L. 1 1.651 507.60 271.01
## - TBA..uM. 1 1.812 507.76 271.10
## - Acetylcholine 1 1.937 507.88 271.17
## - Phenol 1 2.832 508.78 271.69
## - N.acetyl.aspartic.acid 1 3.116 509.06 271.85
## - Urocanic.acid 1 3.127 509.07 271.86
## <none> 505.95 272.05
## - Phenyllactate 1 3.502 509.45 272.07
## - EO.... 1 3.649 509.60 272.16
## - Bilirubin 1 3.825 509.77 272.26
## - Sphinganine.1.phosphate 1 3.950 509.90 272.33
## - Homovanillic.acid.sulfate 1 3.991 509.94 272.36
## - N8.Acetylspermidine 1 4.525 510.47 272.66
## - X2.Hydroxy.Hippuric.Acid 1 5.378 511.33 273.15
## + Cre..uM. 1 1.335 504.61 273.28
## - ALB..g.L. 1 5.728 511.68 273.35
## + Hippuric.acid 1 1.209 504.74 273.35
## + X4.Hydroxyphenyllactate 1 1.190 504.76 273.36
## - Cholesterol.sulfate 1 5.829 511.78 273.41
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.979 504.97 273.49
## - Cinnamoylglycine 1 6.013 511.96 273.52
## + Iodide 1 0.919 505.03 273.52
## - Bilirubin.1 1 6.085 512.03 273.56
## - Imidazolepropionic.acid 1 6.132 512.08 273.58
## + X3.Hydroxybenzoic.acid 1 0.774 505.17 273.61
## + Biliverdin 1 0.537 505.41 273.74
## + X4.Hydroxybenzoic.acid 1 0.506 505.44 273.76
## + Spermidine 1 0.496 505.45 273.77
## + Stearoylethanolamide 1 0.495 505.45 273.77
## + X4.Hydroxyphenylpropionate 1 0.483 505.46 273.77
## + Oleoylethanolamide 1 0.398 505.55 273.82
## + X3.Hydroxyphenylacetic.acid 1 0.363 505.58 273.84
## + Indole.3.propionic.acid 1 0.296 505.65 273.88
## + X5.Methoxyindoleacetate 1 0.251 505.70 273.91
## + X4.Ethylphenyl.sulfate 1 0.205 505.74 273.94
## + Benzoic.acid 1 0.200 505.75 273.94
## + Sphingosine 1 0.179 505.77 273.95
## + p.Cresol.glucuronide 1 0.176 505.77 273.95
## + p.Cresol 1 0.158 505.79 273.96
## + CHE..U.L. 1 0.155 505.79 273.96
## + TC..mM. 1 0.139 505.81 273.97
## + Dopamine 1 0.121 505.83 273.98
## + Sphingosine.1.phosphate 1 0.118 505.83 273.99
## + Urea..mM. 1 0.117 505.83 273.99
## + Dopa 1 0.106 505.84 273.99
## + Palmitic.amide 1 0.083 505.86 274.01
## + BASO.... 1 0.064 505.88 274.02
## + Enterolactone 1 0.031 505.92 274.04
## + Putrescine 1 0.029 505.92 274.04
## + Phenylacetic.acid 1 0.018 505.93 274.04
## + S.gosine.1.phosphate_b 1 0.016 505.93 274.05
## + Υ.GT..U.L. 1 0.010 505.94 274.05
## + WBC..10.9.L. 1 0.004 505.94 274.05
## + LDL.C..mM. 1 0.002 505.95 274.05
## + UA..uM. 1 0.000 505.95 274.05
## - Phenylacetylglutamine.PAGln. 1 7.304 513.25 274.25
## - D.BIL..uM. 1 7.706 513.65 274.48
## - Octadecanamide 1 7.709 513.66 274.49
## - N.Acetylcadaverine 1 7.865 513.81 274.57
## - Oleamide 1 8.131 514.08 274.73
## - T.BIL..uM. 1 8.185 514.13 274.76
## - Salicylic.acid 1 8.366 514.31 274.86
## - Phenylethylamine 1 8.781 514.73 275.10
## - Xanthurenic.acid 1 9.136 515.08 275.30
## - LYMPH.... 1 9.205 515.15 275.34
## - X3.Hydroxyhippuric.acid 1 9.271 515.22 275.38
## - NEUT.... 1 9.733 515.68 275.64
## - Gamma.aminobutyric.acid 1 10.571 516.52 276.11
## - Indoxyl.sulfate 1 10.968 516.92 276.34
## - p.Cresol.sulfate 1 12.819 518.77 277.38
## - S.ganine.1.phosphate_b 1 13.004 518.95 277.49
## - Ascorbic.acid 1 15.006 520.95 278.62
## - Phenyl.sulfate 1 15.444 521.39 278.86
## - X3.Hydroxyanthranilic.acid 1 16.866 522.81 279.66
## - Indole.3.carboxaldehyde 1 17.301 523.25 279.91
## - Kynurenic.acid 1 18.698 524.65 280.69
## - Pantothenol 1 18.993 524.94 280.85
## - AST..U.L. 1 19.047 524.99 280.88
## - X5.Aminopentanoic.acid 1 19.999 525.95 281.41
## - Acetylglycine 1 21.713 527.66 282.37
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.658 528.61 282.89
## - X3.Hydroxypropionic.acid 1 26.243 532.19 284.87
## - Indole.3.methyl.acetate 1 27.625 533.57 285.63
## - X1.5.Anhydrosorbitol 1 30.130 536.08 287.00
## - Sphinganine 1 32.106 538.05 288.08
## - HDL.C..mM. 1 33.482 539.43 288.83
## - ALT..U.L. 1 36.501 542.45 290.46
## - Indole.3.acrylic.acid 1 48.904 554.85 297.09
## - Palmitoylethanolamide 1 57.046 562.99 301.36
## - X3.Indolebutyric.acid 1 61.384 567.33 303.61
## - TG..mM. 1 84.292 590.24 315.20
##
## Step: AIC=270.98
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + Acetylcholine +
## N.acetyl.aspartic.acid + N8.Acetylspermidine + Phenol + X1.5.Anhydrosorbitol +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - Acetylcholine 1 1.533 509.08 269.87
## - ALP..U.L. 1 1.636 509.19 269.92
## - TBA..uM. 1 1.879 509.43 270.06
## - Phenol 1 2.606 510.16 270.48
## - Urocanic.acid 1 3.153 510.70 270.80
## - Phenyllactate 1 3.398 510.95 270.94
## <none> 507.55 270.98
## - EO.... 1 3.539 511.09 271.02
## - N.acetyl.aspartic.acid 1 3.648 511.20 271.08
## - Bilirubin 1 3.924 511.47 271.24
## - Homovanillic.acid.sulfate 1 3.969 511.52 271.26
## - Sphinganine.1.phosphate 1 4.100 511.65 271.34
## - N8.Acetylspermidine 1 4.676 512.23 271.67
## + Spermine 1 1.603 505.95 272.05
## - X2.Hydroxy.Hippuric.Acid 1 5.394 512.94 272.08
## + Cre..uM. 1 1.521 506.03 272.10
## + X4.Hydroxyphenyllactate 1 1.260 506.29 272.25
## + Spermidine 1 1.231 506.32 272.27
## + Hippuric.acid 1 1.101 506.45 272.35
## - Cinnamoylglycine 1 5.925 513.48 272.38
## - ALB..g.L. 1 5.948 513.50 272.39
## - Imidazolepropionic.acid 1 6.127 513.68 272.50
## + X3.Hydroxybenzoic.acid 1 0.774 506.78 272.53
## - Bilirubin.1 1 6.231 513.78 272.56
## + Iodide 1 0.726 506.82 272.56
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.720 506.83 272.56
## + Biliverdin 1 0.636 506.91 272.61
## - Cholesterol.sulfate 1 6.356 513.91 272.63
## + X4.Hydroxybenzoic.acid 1 0.535 507.02 272.67
## + Oleoylethanolamide 1 0.513 507.04 272.69
## + Stearoylethanolamide 1 0.404 507.15 272.75
## + X4.Hydroxyphenylpropionate 1 0.360 507.19 272.77
## + Sphingosine 1 0.299 507.25 272.81
## + Indole.3.propionic.acid 1 0.298 507.25 272.81
## + X5.Methoxyindoleacetate 1 0.253 507.30 272.83
## + CHE..U.L. 1 0.251 507.30 272.84
## + X3.Hydroxyphenylacetic.acid 1 0.245 507.31 272.84
## + p.Cresol 1 0.236 507.31 272.85
## + X4.Ethylphenyl.sulfate 1 0.234 507.32 272.85
## + Benzoic.acid 1 0.219 507.33 272.85
## + p.Cresol.glucuronide 1 0.214 507.34 272.86
## + Urea..mM. 1 0.191 507.36 272.87
## + Sphingosine.1.phosphate 1 0.188 507.36 272.87
## + TC..mM. 1 0.114 507.44 272.92
## + Dopamine 1 0.106 507.44 272.92
## + Palmitic.amide 1 0.079 507.47 272.94
## + Putrescine 1 0.069 507.48 272.94
## + Dopa 1 0.063 507.49 272.94
## + LDL.C..mM. 1 0.048 507.50 272.95
## + BASO.... 1 0.040 507.51 272.96
## + Enterolactone 1 0.034 507.52 272.96
## + S.gosine.1.phosphate_b 1 0.033 507.52 272.96
## + WBC..10.9.L. 1 0.025 507.53 272.97
## + Υ.GT..U.L. 1 0.001 507.55 272.98
## + UA..uM. 1 0.001 507.55 272.98
## + Phenylacetic.acid 1 0.000 507.55 272.98
## - Phenylacetylglutamine.PAGln. 1 7.143 514.69 273.08
## - Octadecanamide 1 7.250 514.80 273.14
## - Oleamide 1 7.962 515.51 273.54
## - N.Acetylcadaverine 1 8.095 515.65 273.62
## - LYMPH.... 1 8.312 515.86 273.74
## - Salicylic.acid 1 8.376 515.93 273.78
## - D.BIL..uM. 1 8.516 516.07 273.86
## - NEUT.... 1 8.590 516.14 273.90
## - Phenylethylamine 1 8.740 516.29 273.98
## - X3.Hydroxyhippuric.acid 1 9.105 516.66 274.19
## - Xanthurenic.acid 1 9.141 516.69 274.21
## - T.BIL..uM. 1 9.151 516.70 274.22
## - Gamma.aminobutyric.acid 1 10.563 518.11 275.02
## - Indoxyl.sulfate 1 11.135 518.69 275.34
## - p.Cresol.sulfate 1 12.735 520.29 276.24
## - S.ganine.1.phosphate_b 1 13.389 520.94 276.61
## - Phenyl.sulfate 1 15.172 522.72 277.61
## - Ascorbic.acid 1 16.251 523.80 278.21
## - X3.Hydroxyanthranilic.acid 1 16.631 524.18 278.43
## - Indole.3.carboxaldehyde 1 17.484 525.03 278.90
## - Pantothenol 1 19.240 526.79 279.88
## - Kynurenic.acid 1 19.346 526.90 279.94
## - X5.Aminopentanoic.acid 1 19.796 527.35 280.19
## - AST..U.L. 1 20.226 527.78 280.43
## - Acetylglycine 1 21.275 528.83 281.01
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.208 529.76 281.53
## - X3.Hydroxypropionic.acid 1 24.858 532.41 282.99
## - Indole.3.methyl.acetate 1 27.658 535.21 284.53
## - Sphinganine 1 30.746 538.30 286.21
## - X1.5.Anhydrosorbitol 1 32.692 540.24 287.27
## - HDL.C..mM. 1 35.427 542.98 288.75
## - ALT..U.L. 1 37.316 544.87 289.77
## - Indole.3.acrylic.acid 1 48.307 555.86 295.62
## - Palmitoylethanolamide 1 58.720 566.27 301.06
## - X3.Indolebutyric.acid 1 60.141 567.69 301.79
## - TG..mM. 1 85.026 592.58 314.36
##
## Step: AIC=269.87
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## ALP..U.L. + T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... +
## LYMPH.... + EO.... + Phenylethylamine + Octadecanamide +
## Urocanic.acid + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + N.acetyl.aspartic.acid +
## N8.Acetylspermidine + Phenol + X1.5.Anhydrosorbitol + Salicylic.acid +
## Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - ALP..U.L. 1 1.547 510.63 268.75
## - TBA..uM. 1 1.823 510.91 268.91
## - Phenol 1 2.731 511.81 269.43
## - Urocanic.acid 1 2.933 512.02 269.55
## - N.acetyl.aspartic.acid 1 3.092 512.18 269.64
## - EO.... 1 3.339 512.42 269.78
## - Bilirubin 1 3.451 512.54 269.85
## <none> 509.08 269.87
## - Homovanillic.acid.sulfate 1 3.709 512.79 269.99
## - Sphinganine.1.phosphate 1 4.018 513.10 270.17
## - Phenyllactate 1 4.418 513.50 270.40
## - X2.Hydroxy.Hippuric.Acid 1 4.982 514.07 270.72
## - Cinnamoylglycine 1 5.377 514.46 270.94
## + Acetylcholine 1 1.533 507.55 270.98
## - N8.Acetylspermidine 1 5.507 514.59 271.02
## + Cre..uM. 1 1.391 507.69 271.06
## - Bilirubin.1 1 5.768 514.85 271.17
## + Spermine 1 1.199 507.88 271.17
## + Hippuric.acid 1 1.126 507.96 271.22
## + X4.Hydroxyphenyllactate 1 1.114 507.97 271.22
## + X3.Hydroxybenzoic.acid 1 1.046 508.04 271.26
## - Imidazolepropionic.acid 1 6.013 515.10 271.31
## + Spermidine 1 0.764 508.32 271.43
## + Iodide 1 0.644 508.44 271.49
## + Biliverdin 1 0.597 508.49 271.52
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.562 508.52 271.54
## - Cholesterol.sulfate 1 6.451 515.53 271.56
## + X4.Hydroxybenzoic.acid 1 0.456 508.63 271.60
## + p.Cresol 1 0.416 508.67 271.63
## + Sphingosine 1 0.353 508.73 271.66
## + Dopa 1 0.348 508.74 271.67
## + Indole.3.propionic.acid 1 0.332 508.75 271.67
## + X4.Hydroxyphenylpropionate 1 0.332 508.75 271.67
## + X3.Hydroxyphenylacetic.acid 1 0.326 508.76 271.68
## + Stearoylethanolamide 1 0.325 508.76 271.68
## + Oleoylethanolamide 1 0.324 508.76 271.68
## + Benzoic.acid 1 0.289 508.80 271.70
## + Dopamine 1 0.263 508.82 271.71
## + X4.Ethylphenyl.sulfate 1 0.230 508.85 271.73
## - ALB..g.L. 1 6.768 515.85 271.74
## + TC..mM. 1 0.202 508.88 271.75
## + p.Cresol.glucuronide 1 0.146 508.94 271.78
## + Urea..mM. 1 0.145 508.94 271.78
## + X5.Methoxyindoleacetate 1 0.140 508.94 271.79
## + CHE..U.L. 1 0.111 508.97 271.80
## + Sphingosine.1.phosphate 1 0.093 508.99 271.81
## + WBC..10.9.L. 1 0.084 509.00 271.82
## + Palmitic.amide 1 0.074 509.01 271.82
## + BASO.... 1 0.047 509.04 271.84
## + LDL.C..mM. 1 0.034 509.05 271.85
## + Enterolactone 1 0.026 509.06 271.85
## + S.gosine.1.phosphate_b 1 0.012 509.07 271.86
## + Phenylacetic.acid 1 0.004 509.08 271.86
## + Υ.GT..U.L. 1 0.004 509.08 271.86
## + UA..uM. 1 0.002 509.08 271.86
## + Putrescine 1 0.000 509.08 271.87
## - Phenylacetylglutamine.PAGln. 1 7.122 516.21 271.94
## - Octadecanamide 1 7.192 516.28 271.98
## - Oleamide 1 7.733 516.82 272.28
## - Salicylic.acid 1 7.997 517.08 272.43
## - LYMPH.... 1 8.140 517.22 272.51
## - NEUT.... 1 8.417 517.50 272.67
## - N.Acetylcadaverine 1 8.436 517.52 272.68
## - D.BIL..uM. 1 8.998 518.08 273.00
## - X3.Hydroxyhippuric.acid 1 9.561 518.64 273.32
## - Phenylethylamine 1 9.601 518.68 273.34
## - T.BIL..uM. 1 9.694 518.78 273.39
## - Xanthurenic.acid 1 10.484 519.57 273.84
## - Indoxyl.sulfate 1 11.359 520.44 274.33
## - Gamma.aminobutyric.acid 1 11.655 520.74 274.50
## - p.Cresol.sulfate 1 12.479 521.56 274.96
## - S.ganine.1.phosphate_b 1 13.105 522.19 275.31
## - Phenyl.sulfate 1 14.295 523.38 275.98
## - X3.Hydroxyanthranilic.acid 1 15.459 524.54 276.63
## - Ascorbic.acid 1 16.662 525.75 277.30
## - Indole.3.carboxaldehyde 1 17.855 526.94 277.96
## - Kynurenic.acid 1 18.239 527.32 278.18
## - X5.Aminopentanoic.acid 1 18.473 527.56 278.31
## - Pantothenol 1 18.692 527.78 278.43
## - Acetylglycine 1 19.755 528.84 279.02
## - AST..U.L. 1 20.608 529.69 279.49
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.409 532.49 281.04
## - X3.Hydroxypropionic.acid 1 24.341 533.42 281.55
## - Indole.3.methyl.acetate 1 28.698 537.78 283.93
## - Sphinganine 1 29.568 538.65 284.41
## - X1.5.Anhydrosorbitol 1 34.405 543.49 287.03
## - HDL.C..mM. 1 34.462 543.55 287.06
## - ALT..U.L. 1 38.289 547.37 289.11
## - Indole.3.acrylic.acid 1 49.605 558.69 295.11
## - X3.Indolebutyric.acid 1 61.277 570.36 301.17
## - Palmitoylethanolamide 1 63.977 573.06 302.55
## - TG..mM. 1 83.522 592.61 312.38
##
## Step: AIC=268.75
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + TBA..uM. + NEUT.... + LYMPH.... +
## EO.... + Phenylethylamine + Octadecanamide + Urocanic.acid +
## Imidazolepropionic.acid + Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid +
## Oleamide + Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - TBA..uM. 1 1.418 512.05 267.57
## - Urocanic.acid 1 2.854 513.48 268.39
## - Phenol 1 3.122 513.75 268.54
## - EO.... 1 3.293 513.92 268.64
## - N.acetyl.aspartic.acid 1 3.298 513.93 268.64
## - Bilirubin 1 3.318 513.95 268.65
## <none> 510.63 268.75
## - Sphinganine.1.phosphate 1 4.179 514.81 269.14
## - Homovanillic.acid.sulfate 1 4.780 515.41 269.48
## - X2.Hydroxy.Hippuric.Acid 1 5.073 515.70 269.65
## - Phenyllactate 1 5.448 516.08 269.86
## + ALP..U.L. 1 1.547 509.08 269.87
## - Cholesterol.sulfate 1 5.466 516.10 269.87
## - N8.Acetylspermidine 1 5.510 516.14 269.90
## + Acetylcholine 1 1.444 509.19 269.92
## - Bilirubin.1 1 5.701 516.33 270.01
## - Imidazolepropionic.acid 1 5.747 516.38 270.03
## + Spermine 1 1.196 509.43 270.07
## + Cre..uM. 1 1.189 509.44 270.07
## - Cinnamoylglycine 1 5.826 516.46 270.08
## + Hippuric.acid 1 1.089 509.54 270.13
## + X3.Hydroxybenzoic.acid 1 0.883 509.75 270.25
## + X4.Hydroxyphenyllactate 1 0.873 509.76 270.25
## + Spermidine 1 0.723 509.91 270.34
## + Iodide 1 0.695 509.94 270.36
## + Biliverdin 1 0.663 509.97 270.37
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.460 510.17 270.49
## + p.Cresol 1 0.439 510.19 270.50
## + Dopa 1 0.424 510.21 270.51
## + X3.Hydroxyphenylacetic.acid 1 0.400 510.23 270.52
## + X4.Hydroxyphenylpropionate 1 0.386 510.24 270.53
## + Oleoylethanolamide 1 0.345 510.29 270.56
## + Indole.3.propionic.acid 1 0.331 510.30 270.56
## + X4.Hydroxybenzoic.acid 1 0.331 510.30 270.56
## + X4.Ethylphenyl.sulfate 1 0.307 510.32 270.58
## + Stearoylethanolamide 1 0.273 510.36 270.60
## + X5.Methoxyindoleacetate 1 0.266 510.36 270.60
## + Benzoic.acid 1 0.229 510.40 270.62
## + CHE..U.L. 1 0.217 510.41 270.63
## + Sphingosine 1 0.214 510.42 270.63
## + LDL.C..mM. 1 0.209 510.42 270.63
## + p.Cresol.glucuronide 1 0.161 510.47 270.66
## + Dopamine 1 0.152 510.48 270.67
## + TC..mM. 1 0.105 510.53 270.69
## - Phenylacetylglutamine.PAGln. 1 6.950 517.58 270.71
## + Palmitic.amide 1 0.045 510.59 270.73
## + WBC..10.9.L. 1 0.045 510.59 270.73
## + Sphingosine.1.phosphate 1 0.032 510.60 270.74
## + Putrescine 1 0.015 510.62 270.75
## + Urea..mM. 1 0.014 510.62 270.75
## + S.gosine.1.phosphate_b 1 0.010 510.62 270.75
## + Υ.GT..U.L. 1 0.007 510.62 270.75
## + Enterolactone 1 0.006 510.62 270.75
## + UA..uM. 1 0.004 510.63 270.75
## + Phenylacetic.acid 1 0.000 510.63 270.75
## + BASO.... 1 0.000 510.63 270.75
## - Octadecanamide 1 7.496 518.13 271.02
## - ALB..g.L. 1 7.657 518.29 271.12
## - Oleamide 1 7.926 518.56 271.27
## - N.Acetylcadaverine 1 8.144 518.77 271.39
## - D.BIL..uM. 1 8.276 518.91 271.46
## - Salicylic.acid 1 8.431 519.06 271.55
## - NEUT.... 1 8.481 519.11 271.58
## - LYMPH.... 1 8.812 519.44 271.77
## - X3.Hydroxyhippuric.acid 1 9.014 519.64 271.88
## - T.BIL..uM. 1 9.156 519.79 271.96
## - Phenylethylamine 1 9.895 520.53 272.38
## - Gamma.aminobutyric.acid 1 11.072 521.70 273.04
## - Xanthurenic.acid 1 11.278 521.91 273.15
## - Indoxyl.sulfate 1 11.874 522.50 273.49
## - p.Cresol.sulfate 1 11.924 522.55 273.52
## - S.ganine.1.phosphate_b 1 14.206 524.84 274.79
## - X3.Hydroxyanthranilic.acid 1 14.354 524.98 274.88
## - Phenyl.sulfate 1 14.964 525.59 275.22
## - X5.Aminopentanoic.acid 1 17.401 528.03 276.57
## - Indole.3.carboxaldehyde 1 18.147 528.78 276.99
## - Ascorbic.acid 1 18.314 528.94 277.08
## - Kynurenic.acid 1 18.985 529.62 277.45
## - Pantothenol 1 19.071 529.70 277.50
## - AST..U.L. 1 21.584 532.21 278.88
## - Acetylglycine 1 21.674 532.30 278.93
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 22.677 533.31 279.49
## - X3.Hydroxypropionic.acid 1 24.640 535.27 280.56
## - Indole.3.methyl.acetate 1 29.274 539.90 283.09
## - Sphinganine 1 30.658 541.29 283.84
## - X1.5.Anhydrosorbitol 1 33.696 544.33 285.48
## - HDL.C..mM. 1 34.198 544.83 285.75
## - ALT..U.L. 1 39.531 550.16 288.60
## - Indole.3.acrylic.acid 1 50.217 560.85 294.24
## - X3.Indolebutyric.acid 1 60.570 571.20 299.60
## - Palmitoylethanolamide 1 62.462 573.09 300.57
## - TG..mM. 1 84.039 594.67 311.39
##
## Step: AIC=267.57
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + NEUT.... + LYMPH.... + EO.... +
## Phenylethylamine + Octadecanamide + Urocanic.acid + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - Urocanic.acid 1 2.723 514.77 267.12
## - EO.... 1 2.865 514.91 267.20
## - N.acetyl.aspartic.acid 1 2.954 515.00 267.25
## - Phenol 1 3.101 515.15 267.33
## - Bilirubin 1 3.466 515.51 267.54
## <none> 512.05 267.57
## - Homovanillic.acid.sulfate 1 4.735 516.78 268.26
## - X2.Hydroxy.Hippuric.Acid 1 4.989 517.04 268.41
## - Sphinganine.1.phosphate 1 5.108 517.16 268.48
## - Imidazolepropionic.acid 1 5.224 517.27 268.54
## + TBA..uM. 1 1.418 510.63 268.75
## + Acetylcholine 1 1.408 510.64 268.76
## - Cholesterol.sulfate 1 5.645 517.69 268.78
## + Spermine 1 1.252 510.80 268.85
## + Cre..uM. 1 1.241 510.81 268.86
## + ALP..U.L. 1 1.141 510.91 268.91
## - N8.Acetylspermidine 1 5.924 517.97 268.94
## + Hippuric.acid 1 1.066 510.98 268.96
## - Phenyllactate 1 6.031 518.08 269.00
## + Iodide 1 0.921 511.13 269.04
## - Bilirubin.1 1 6.171 518.22 269.08
## - Cinnamoylglycine 1 6.213 518.26 269.10
## - Phenylacetylglutamine.PAGln. 1 6.294 518.34 269.15
## + X3.Hydroxybenzoic.acid 1 0.656 511.39 269.19
## + X4.Hydroxyphenyllactate 1 0.600 511.45 269.22
## + Spermidine 1 0.553 511.50 269.25
## + Biliverdin 1 0.466 511.58 269.30
## + X4.Hydroxyphenylpropionate 1 0.456 511.59 269.31
## + p.Cresol 1 0.447 511.60 269.31
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.413 511.64 269.33
## + X4.Hydroxybenzoic.acid 1 0.380 511.67 269.35
## + X3.Hydroxyphenylacetic.acid 1 0.376 511.67 269.35
## + Dopa 1 0.336 511.71 269.37
## + Indole.3.propionic.acid 1 0.308 511.74 269.39
## + X5.Methoxyindoleacetate 1 0.260 511.79 269.42
## + Sphingosine 1 0.235 511.81 269.43
## + LDL.C..mM. 1 0.209 511.84 269.45
## + CHE..U.L. 1 0.184 511.86 269.46
## + Oleoylethanolamide 1 0.173 511.88 269.47
## + Benzoic.acid 1 0.169 511.88 269.47
## + Stearoylethanolamide 1 0.150 511.90 269.48
## + p.Cresol.glucuronide 1 0.147 511.90 269.48
## + WBC..10.9.L. 1 0.143 511.91 269.49
## + X4.Ethylphenyl.sulfate 1 0.139 511.91 269.49
## + Dopamine 1 0.137 511.91 269.49
## + TC..mM. 1 0.135 511.91 269.49
## + Palmitic.amide 1 0.026 512.02 269.55
## + Urea..mM. 1 0.021 512.03 269.55
## + Enterolactone 1 0.013 512.04 269.56
## + S.gosine.1.phosphate_b 1 0.012 512.04 269.56
## + Sphingosine.1.phosphate 1 0.010 512.04 269.56
## + Putrescine 1 0.004 512.04 269.56
## + UA..uM. 1 0.003 512.05 269.56
## + BASO.... 1 0.002 512.05 269.56
## + Υ.GT..U.L. 1 0.001 512.05 269.57
## + Phenylacetic.acid 1 0.000 512.05 269.57
## - ALB..g.L. 1 7.310 519.36 269.72
## - Octadecanamide 1 7.621 519.67 269.89
## - Oleamide 1 7.668 519.72 269.92
## - NEUT.... 1 7.961 520.01 270.09
## - Salicylic.acid 1 8.178 520.23 270.21
## - D.BIL..uM. 1 8.520 520.57 270.40
## - LYMPH.... 1 8.582 520.63 270.44
## - X3.Hydroxyhippuric.acid 1 8.995 521.04 270.67
## - T.BIL..uM. 1 9.385 521.43 270.89
## - Phenylethylamine 1 9.862 521.91 271.16
## - N.Acetylcadaverine 1 9.955 522.00 271.21
## - Gamma.aminobutyric.acid 1 10.269 522.32 271.38
## - Xanthurenic.acid 1 11.018 523.07 271.80
## - Indoxyl.sulfate 1 11.495 523.54 272.07
## - p.Cresol.sulfate 1 12.295 524.34 272.52
## - X3.Hydroxyanthranilic.acid 1 14.824 526.87 273.93
## - Phenyl.sulfate 1 15.029 527.08 274.04
## - S.ganine.1.phosphate_b 1 16.295 528.34 274.75
## - X5.Aminopentanoic.acid 1 16.829 528.88 275.04
## - Indole.3.carboxaldehyde 1 17.501 529.55 275.41
## - Ascorbic.acid 1 18.197 530.25 275.80
## - Pantothenol 1 18.556 530.61 276.00
## - Acetylglycine 1 20.826 532.87 277.25
## - Kynurenic.acid 1 21.854 533.90 277.81
## - AST..U.L. 1 22.940 534.99 278.41
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 23.209 535.26 278.56
## - X3.Hydroxypropionic.acid 1 24.444 536.49 279.23
## - Indole.3.methyl.acetate 1 28.663 540.71 281.52
## - Sphinganine 1 31.083 543.13 282.83
## - X1.5.Anhydrosorbitol 1 32.883 544.93 283.80
## - HDL.C..mM. 1 35.037 547.09 284.96
## - ALT..U.L. 1 39.989 552.04 287.60
## - Indole.3.acrylic.acid 1 49.460 561.51 292.58
## - X3.Indolebutyric.acid 1 59.216 571.26 297.63
## - Palmitoylethanolamide 1 61.511 573.56 298.81
## - TG..mM. 1 83.415 595.46 309.79
##
## Step: AIC=267.12
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + NEUT.... + LYMPH.... + EO.... +
## Phenylethylamine + Octadecanamide + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + N.acetyl.aspartic.acid + N8.Acetylspermidine +
## Phenol + X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate +
## Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - N.acetyl.aspartic.acid 1 2.839 517.61 266.73
## - Phenol 1 2.932 517.70 266.78
## - EO.... 1 3.404 518.18 267.05
## <none> 514.77 267.12
## - Bilirubin 1 4.167 518.94 267.48
## + Urocanic.acid 1 2.723 512.05 267.57
## - Sphinganine.1.phosphate 1 5.113 519.89 268.02
## - X2.Hydroxy.Hippuric.Acid 1 5.182 519.95 268.06
## - Homovanillic.acid.sulfate 1 5.195 519.97 268.06
## - Imidazolepropionic.acid 1 5.212 519.98 268.07
## + Cre..uM. 1 1.764 513.01 268.12
## - Cinnamoylglycine 1 5.531 520.30 268.25
## - N8.Acetylspermidine 1 5.718 520.49 268.36
## + Spermine 1 1.297 513.47 268.38
## + TBA..uM. 1 1.288 513.48 268.39
## + Acetylcholine 1 1.208 513.56 268.43
## - Phenyllactate 1 5.957 520.73 268.49
## + Iodide 1 1.101 513.67 268.49
## + ALP..U.L. 1 1.092 513.68 268.50
## - Cholesterol.sulfate 1 5.971 520.74 268.50
## + Hippuric.acid 1 1.010 513.76 268.55
## + X4.Hydroxyphenyllactate 1 0.777 513.99 268.68
## + X3.Hydroxybenzoic.acid 1 0.699 514.07 268.72
## + X4.Hydroxyphenylpropionate 1 0.564 514.21 268.80
## + Spermidine 1 0.548 514.22 268.81
## + p.Cresol 1 0.513 514.26 268.83
## + Dopa 1 0.504 514.27 268.83
## + X4.Hydroxybenzoic.acid 1 0.493 514.28 268.84
## + X3.Hydroxyphenylacetic.acid 1 0.406 514.37 268.89
## + Biliverdin 1 0.384 514.39 268.90
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.382 514.39 268.90
## + X5.Methoxyindoleacetate 1 0.369 514.40 268.91
## - Bilirubin.1 1 6.750 521.52 268.94
## + Indole.3.propionic.acid 1 0.300 514.47 268.95
## + LDL.C..mM. 1 0.264 514.51 268.97
## + CHE..U.L. 1 0.192 514.58 269.01
## + Sphingosine 1 0.191 514.58 269.01
## + Oleoylethanolamide 1 0.175 514.60 269.02
## + p.Cresol.glucuronide 1 0.158 514.61 269.03
## + WBC..10.9.L. 1 0.155 514.62 269.03
## + Dopamine 1 0.146 514.63 269.04
## + Stearoylethanolamide 1 0.141 514.63 269.04
## + TC..mM. 1 0.138 514.63 269.04
## + Palmitic.amide 1 0.122 514.65 269.05
## - Phenylacetylglutamine.PAGln. 1 7.003 521.77 269.08
## + Benzoic.acid 1 0.070 514.70 269.08
## + X4.Ethylphenyl.sulfate 1 0.068 514.70 269.08
## + Urea..mM. 1 0.043 514.73 269.10
## + Sphingosine.1.phosphate 1 0.012 514.76 269.11
## + BASO.... 1 0.012 514.76 269.11
## + Enterolactone 1 0.011 514.76 269.11
## + UA..uM. 1 0.005 514.77 269.12
## + Υ.GT..U.L. 1 0.002 514.77 269.12
## + Putrescine 1 0.001 514.77 269.12
## + S.gosine.1.phosphate_b 1 0.000 514.77 269.12
## + Phenylacetic.acid 1 0.000 514.77 269.12
## - ALB..g.L. 1 7.378 522.15 269.29
## - NEUT.... 1 7.910 522.68 269.59
## - Octadecanamide 1 8.202 522.97 269.75
## - Salicylic.acid 1 8.380 523.15 269.85
## - Oleamide 1 8.645 523.42 270.00
## - D.BIL..uM. 1 8.711 523.48 270.04
## - LYMPH.... 1 8.939 523.71 270.17
## - Phenylethylamine 1 9.193 523.96 270.31
## - X3.Hydroxyhippuric.acid 1 9.560 524.33 270.51
## - N.Acetylcadaverine 1 9.571 524.34 270.52
## - T.BIL..uM. 1 9.747 524.52 270.62
## - Xanthurenic.acid 1 10.460 525.23 271.01
## - Gamma.aminobutyric.acid 1 10.541 525.31 271.06
## - Indoxyl.sulfate 1 11.313 526.08 271.49
## - p.Cresol.sulfate 1 13.303 528.08 272.60
## - X3.Hydroxyanthranilic.acid 1 13.890 528.66 272.92
## - S.ganine.1.phosphate_b 1 15.731 530.50 273.94
## - X5.Aminopentanoic.acid 1 16.220 530.99 274.21
## - Phenyl.sulfate 1 16.384 531.16 274.30
## - Ascorbic.acid 1 17.199 531.97 274.75
## - Indole.3.carboxaldehyde 1 17.661 532.43 275.00
## - Pantothenol 1 18.132 532.90 275.26
## - Acetylglycine 1 21.044 535.82 276.86
## - Kynurenic.acid 1 23.043 537.81 277.95
## - AST..U.L. 1 23.314 538.09 278.10
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 24.361 539.13 278.67
## - X3.Hydroxypropionic.acid 1 24.886 539.66 278.95
## - Indole.3.methyl.acetate 1 30.471 545.24 281.97
## - Sphinganine 1 30.566 545.34 282.02
## - X1.5.Anhydrosorbitol 1 31.201 545.97 282.36
## - HDL.C..mM. 1 35.311 550.08 284.56
## - ALT..U.L. 1 40.450 555.22 287.28
## - Indole.3.acrylic.acid 1 51.849 566.62 293.24
## - X3.Indolebutyric.acid 1 57.187 571.96 295.99
## - Palmitoylethanolamide 1 62.212 576.98 298.55
## - TG..mM. 1 83.685 598.46 309.25
##
## Step: AIC=266.73
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + NEUT.... + LYMPH.... + EO.... +
## Phenylethylamine + Octadecanamide + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + N8.Acetylspermidine + Phenol + X1.5.Anhydrosorbitol +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - Phenol 1 2.762 520.37 266.29
## <none> 517.61 266.73
## - EO.... 1 3.545 521.16 266.73
## - Bilirubin 1 3.811 521.42 266.88
## + N.acetyl.aspartic.acid 1 2.839 514.77 267.12
## + Urocanic.acid 1 2.608 515.00 267.25
## - Sphinganine.1.phosphate 1 5.306 522.92 267.72
## + Spermine 1 1.783 515.83 267.72
## - Imidazolepropionic.acid 1 5.399 523.01 267.77
## - X2.Hydroxy.Hippuric.Acid 1 5.517 523.13 267.84
## - Cholesterol.sulfate 1 5.763 523.37 267.98
## + ALP..U.L. 1 1.297 516.31 268.00
## + Iodide 1 1.197 516.41 268.05
## - Cinnamoylglycine 1 5.979 523.59 268.10
## - Homovanillic.acid.sulfate 1 6.101 523.71 268.17
## + Hippuric.acid 1 0.994 516.62 268.17
## + TBA..uM. 1 0.970 516.64 268.18
## - N8.Acetylspermidine 1 6.208 523.82 268.23
## + X3.Hydroxybenzoic.acid 1 0.880 516.73 268.23
## + X3.Hydroxyphenylacetic.acid 1 0.780 516.83 268.29
## + Acetylcholine 1 0.742 516.87 268.31
## + X4.Hydroxyphenyllactate 1 0.651 516.96 268.36
## - Phenyllactate 1 6.457 524.07 268.36
## + Spermidine 1 0.571 517.04 268.41
## + X4.Hydroxybenzoic.acid 1 0.556 517.05 268.42
## + Cre..uM. 1 0.490 517.12 268.45
## + p.Cresol 1 0.446 517.16 268.48
## + Indole.3.propionic.acid 1 0.423 517.19 268.49
## + X4.Hydroxyphenylpropionate 1 0.350 517.26 268.53
## + X5.Methoxyindoleacetate 1 0.331 517.28 268.54
## + LDL.C..mM. 1 0.324 517.29 268.55
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.259 517.35 268.58
## + Biliverdin 1 0.257 517.35 268.59
## + CHE..U.L. 1 0.232 517.38 268.60
## + Dopamine 1 0.198 517.41 268.62
## + TC..mM. 1 0.176 517.43 268.63
## + Dopa 1 0.163 517.45 268.64
## + Benzoic.acid 1 0.159 517.45 268.64
## + Oleoylethanolamide 1 0.138 517.47 268.65
## + WBC..10.9.L. 1 0.126 517.48 268.66
## + p.Cresol.glucuronide 1 0.124 517.49 268.66
## + Sphingosine 1 0.092 517.52 268.68
## + BASO.... 1 0.076 517.53 268.69
## + Stearoylethanolamide 1 0.069 517.54 268.69
## + Palmitic.amide 1 0.066 517.54 268.69
## + Enterolactone 1 0.044 517.57 268.71
## + Sphingosine.1.phosphate 1 0.031 517.58 268.71
## + Υ.GT..U.L. 1 0.021 517.59 268.72
## + Urea..mM. 1 0.017 517.59 268.72
## + Putrescine 1 0.016 517.59 268.72
## - Bilirubin.1 1 7.100 524.71 268.72
## + Phenylacetic.acid 1 0.001 517.61 268.73
## + UA..uM. 1 0.001 517.61 268.73
## + X4.Ethylphenyl.sulfate 1 0.000 517.61 268.73
## + S.gosine.1.phosphate_b 1 0.000 517.61 268.73
## - ALB..g.L. 1 7.314 524.92 268.84
## - Octadecanamide 1 7.621 525.23 269.01
## - Phenylacetylglutamine.PAGln. 1 7.797 525.41 269.11
## - Oleamide 1 8.189 525.80 269.33
## - Salicylic.acid 1 8.495 526.11 269.50
## - Phenylethylamine 1 9.138 526.75 269.86
## - NEUT.... 1 9.272 526.88 269.93
## - X3.Hydroxyhippuric.acid 1 9.602 527.21 270.12
## - N.Acetylcadaverine 1 9.661 527.27 270.15
## - Xanthurenic.acid 1 10.029 527.64 270.36
## - LYMPH.... 1 10.306 527.92 270.51
## - D.BIL..uM. 1 10.596 528.21 270.67
## - Gamma.aminobutyric.acid 1 11.129 528.74 270.96
## - Indoxyl.sulfate 1 11.683 529.29 271.27
## - T.BIL..uM. 1 11.690 529.30 271.27
## - X3.Hydroxyanthranilic.acid 1 13.143 530.75 272.08
## - p.Cresol.sulfate 1 13.730 531.34 272.40
## - X5.Aminopentanoic.acid 1 15.858 533.47 273.57
## - S.ganine.1.phosphate_b 1 16.208 533.82 273.77
## - Ascorbic.acid 1 17.159 534.77 274.29
## - Phenyl.sulfate 1 17.251 534.86 274.34
## - Indole.3.carboxaldehyde 1 17.421 535.03 274.43
## - Pantothenol 1 17.514 535.12 274.48
## - AST..U.L. 1 22.882 540.49 277.41
## - X3.Hydroxypropionic.acid 1 23.494 541.10 277.74
## - Kynurenic.acid 1 24.901 542.51 278.50
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 25.067 542.68 278.59
## - Acetylglycine 1 26.226 543.84 279.21
## - Sphinganine 1 30.602 548.21 281.56
## - Indole.3.methyl.acetate 1 30.919 548.53 281.73
## - X1.5.Anhydrosorbitol 1 34.211 551.82 283.48
## - HDL.C..mM. 1 36.075 553.69 284.47
## - ALT..U.L. 1 39.402 557.01 286.23
## - Indole.3.acrylic.acid 1 52.984 570.59 293.29
## - X3.Indolebutyric.acid 1 59.605 577.22 296.67
## - Palmitoylethanolamide 1 61.870 579.48 297.81
## - TG..mM. 1 85.925 603.54 309.73
##
## Step: AIC=266.29
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + NEUT.... + LYMPH.... + EO.... +
## Phenylethylamine + Octadecanamide + Imidazolepropionic.acid +
## Indole.3.carboxaldehyde + X3.Hydroxyanthranilic.acid + Oleamide +
## Palmitoylethanolamide + Bilirubin + Indole.3.acrylic.acid +
## Kynurenic.acid + Indole.3.methyl.acetate + Sphinganine +
## Sphinganine.1.phosphate + X3.Indolebutyric.acid + Phenylacetylglutamine.PAGln. +
## Pantothenol + Gamma.aminobutyric.acid + X5.Aminopentanoic.acid +
## N.Acetylcadaverine + N8.Acetylspermidine + X1.5.Anhydrosorbitol +
## Salicylic.acid + Phenyllactate + Bilirubin.1 + X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid +
## p.Cresol.sulfate + X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid +
## S.ganine.1.phosphate_b + Cholesterol.sulfate + Xanthurenic.acid +
## Cinnamoylglycine + Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## - EO.... 1 3.165 523.54 266.07
## <none> 520.37 266.29
## - Bilirubin 1 4.057 524.43 266.57
## - Cinnamoylglycine 1 4.353 524.73 266.73
## + Phenol 1 2.762 517.61 266.73
## + N.acetyl.aspartic.acid 1 2.669 517.70 266.78
## + Urocanic.acid 1 2.450 517.92 266.91
## - Imidazolepropionic.acid 1 5.111 525.48 267.15
## + ALP..U.L. 1 1.629 518.74 267.37
## + Spermine 1 1.506 518.87 267.44
## - N8.Acetylspermidine 1 5.779 526.15 267.53
## + Hippuric.acid 1 1.279 519.09 267.57
## - X2.Hydroxy.Hippuric.Acid 1 5.881 526.25 267.58
## - Cholesterol.sulfate 1 5.900 526.27 267.59
## + Iodide 1 1.181 519.19 267.62
## + TBA..uM. 1 0.965 519.41 267.75
## + X3.Hydroxyphenylacetic.acid 1 0.951 519.42 267.75
## + X3.Hydroxybenzoic.acid 1 0.947 519.42 267.76
## - Sphinganine.1.phosphate 1 6.301 526.67 267.82
## + Acetylcholine 1 0.840 519.53 267.82
## + Spermidine 1 0.689 519.68 267.90
## + X4.Hydroxyphenyllactate 1 0.651 519.72 267.92
## + p.Cresol 1 0.576 519.80 267.97
## + X5.Methoxyindoleacetate 1 0.510 519.86 268.00
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.432 519.94 268.05
## + X4.Hydroxybenzoic.acid 1 0.427 519.95 268.05
## + Biliverdin 1 0.419 519.95 268.06
## + Indole.3.propionic.acid 1 0.385 519.99 268.07
## - Homovanillic.acid.sulfate 1 6.789 527.16 268.09
## + Cre..uM. 1 0.337 520.04 268.10
## + LDL.C..mM. 1 0.271 520.10 268.14
## - ALB..g.L. 1 6.884 527.26 268.14
## + X4.Hydroxyphenylpropionate 1 0.265 520.11 268.14
## + Dopamine 1 0.223 520.15 268.17
## + Dopa 1 0.190 520.18 268.18
## + BASO.... 1 0.163 520.21 268.20
## + Oleoylethanolamide 1 0.150 520.22 268.21
## + TC..mM. 1 0.146 520.23 268.21
## + CHE..U.L. 1 0.143 520.23 268.21
## + Benzoic.acid 1 0.102 520.27 268.23
## + Enterolactone 1 0.102 520.27 268.23
## + p.Cresol.glucuronide 1 0.079 520.29 268.25
## + Stearoylethanolamide 1 0.075 520.30 268.25
## + Sphingosine 1 0.074 520.30 268.25
## + Palmitic.amide 1 0.045 520.33 268.26
## + WBC..10.9.L. 1 0.026 520.35 268.28
## + Υ.GT..U.L. 1 0.020 520.35 268.28
## + UA..uM. 1 0.015 520.36 268.28
## + Sphingosine.1.phosphate 1 0.008 520.36 268.29
## + Putrescine 1 0.006 520.37 268.29
## + S.gosine.1.phosphate_b 1 0.005 520.37 268.29
## + Urea..mM. 1 0.003 520.37 268.29
## + X4.Ethylphenyl.sulfate 1 0.000 520.37 268.29
## + Phenylacetic.acid 1 0.000 520.37 268.29
## - Phenyllactate 1 7.673 528.05 268.58
## - NEUT.... 1 7.810 528.18 268.66
## - Phenylethylamine 1 8.117 528.49 268.83
## - Bilirubin.1 1 8.175 528.55 268.86
## - LYMPH.... 1 8.328 528.70 268.94
## - Salicylic.acid 1 8.685 529.06 269.14
## - Oleamide 1 8.762 529.13 269.18
## - Xanthurenic.acid 1 8.820 529.19 269.21
## - Octadecanamide 1 8.952 529.32 269.29
## - X3.Hydroxyhippuric.acid 1 9.078 529.45 269.36
## - N.Acetylcadaverine 1 9.134 529.51 269.39
## - Indoxyl.sulfate 1 9.361 529.73 269.51
## - Phenylacetylglutamine.PAGln. 1 9.621 529.99 269.66
## - D.BIL..uM. 1 9.889 530.26 269.81
## - Gamma.aminobutyric.acid 1 10.785 531.16 270.30
## - T.BIL..uM. 1 11.031 531.40 270.44
## - X3.Hydroxyanthranilic.acid 1 13.049 533.42 271.55
## - Phenyl.sulfate 1 14.696 535.07 272.45
## - X5.Aminopentanoic.acid 1 14.810 535.18 272.51
## - Indole.3.carboxaldehyde 1 16.146 536.52 273.24
## - Ascorbic.acid 1 16.523 536.90 273.45
## - p.Cresol.sulfate 1 16.833 537.21 273.62
## - S.ganine.1.phosphate_b 1 17.622 537.99 274.05
## - Pantothenol 1 18.751 539.12 274.66
## - AST..U.L. 1 21.580 541.95 276.20
## - X3.Hydroxypropionic.acid 1 23.109 543.48 277.02
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 25.164 545.54 278.13
## - Acetylglycine 1 25.799 546.17 278.47
## - Kynurenic.acid 1 26.086 546.46 278.62
## - Indole.3.methyl.acetate 1 31.643 552.01 281.59
## - Sphinganine 1 31.992 552.36 281.77
## - X1.5.Anhydrosorbitol 1 35.223 555.60 283.48
## - HDL.C..mM. 1 36.312 556.68 284.06
## - ALT..U.L. 1 37.932 558.30 284.91
## - Indole.3.acrylic.acid 1 52.844 573.22 292.63
## - X3.Indolebutyric.acid 1 57.640 578.01 295.07
## - Palmitoylethanolamide 1 60.910 581.28 296.72
## - TG..mM. 1 86.603 606.98 309.40
##
## Step: AIC=266.07
## FBG..mM. ~ ALT..U.L. + AST..U.L. + ALB..g.L. + TG..mM. + HDL.C..mM. +
## T.BIL..uM. + D.BIL..uM. + NEUT.... + LYMPH.... + Phenylethylamine +
## Octadecanamide + Imidazolepropionic.acid + Indole.3.carboxaldehyde +
## X3.Hydroxyanthranilic.acid + Oleamide + Palmitoylethanolamide +
## Bilirubin + Indole.3.acrylic.acid + Kynurenic.acid + Indole.3.methyl.acetate +
## Sphinganine + Sphinganine.1.phosphate + X3.Indolebutyric.acid +
## Phenylacetylglutamine.PAGln. + Pantothenol + Gamma.aminobutyric.acid +
## X5.Aminopentanoic.acid + N.Acetylcadaverine + N8.Acetylspermidine +
## X1.5.Anhydrosorbitol + Salicylic.acid + Phenyllactate + Bilirubin.1 +
## X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid + p.Cresol.sulfate +
## X2.Hydroxy.Hippuric.Acid + X3.Hydroxyhippuric.acid + S.ganine.1.phosphate_b +
## Cholesterol.sulfate + Xanthurenic.acid + Cinnamoylglycine +
## Indoxyl.sulfate + Ascorbic.acid + Homovanillic.acid.sulfate +
## Phenyl.sulfate + X3.Hydroxypropionic.acid + Acetylglycine
##
## Df Sum of Sq RSS AIC
## <none> 523.54 266.07
## - Cinnamoylglycine 1 3.944 527.48 266.27
## + EO.... 1 3.165 520.37 266.29
## + Urocanic.acid 1 2.953 520.58 266.41
## + N.acetyl.aspartic.acid 1 2.810 520.73 266.49
## + Phenol 1 2.381 521.16 266.73
## - Bilirubin 1 4.944 528.48 266.82
## - NEUT.... 1 5.081 528.62 266.90
## - LYMPH.... 1 5.441 528.98 267.10
## + ALP..U.L. 1 1.628 521.91 267.15
## - N8.Acetylspermidine 1 5.572 529.11 267.17
## - X2.Hydroxy.Hippuric.Acid 1 5.590 529.13 267.18
## - Imidazolepropionic.acid 1 5.650 529.19 267.21
## + Spermine 1 1.454 522.08 267.25
## + X3.Hydroxyphenylacetic.acid 1 1.381 522.16 267.29
## + Iodide 1 1.300 522.24 267.34
## - Cholesterol.sulfate 1 5.920 529.46 267.36
## + X3.Hydroxybenzoic.acid 1 1.117 522.42 267.44
## + Hippuric.acid 1 0.992 522.55 267.51
## - Sphinganine.1.phosphate 1 6.205 529.74 267.52
## + X4.Hydroxyphenyllactate 1 0.924 522.61 267.55
## - Homovanillic.acid.sulfate 1 6.345 529.88 267.60
## + Spermidine 1 0.783 522.75 267.63
## + Acetylcholine 1 0.673 522.86 267.69
## + p.Cresol 1 0.641 522.90 267.71
## + TBA..uM. 1 0.592 522.95 267.74
## + X5.Methoxyindoleacetate 1 0.375 523.16 267.86
## + Dopamine 1 0.354 523.18 267.87
## + LDL.C..mM. 1 0.351 523.19 267.87
## + X4.Hydroxybenzoic.acid.4.O.sulphate 1 0.339 523.20 267.88
## + X4.Hydroxyphenylpropionate 1 0.302 523.24 267.90
## + Cre..uM. 1 0.275 523.26 267.91
## + Indole.3.propionic.acid 1 0.266 523.27 267.92
## - ALB..g.L. 1 6.931 530.47 267.92
## + Biliverdin 1 0.226 523.31 267.94
## + CHE..U.L. 1 0.204 523.33 267.95
## + Benzoic.acid 1 0.192 523.35 267.96
## + Sphingosine 1 0.186 523.35 267.96
## + p.Cresol.glucuronide 1 0.120 523.42 268.00
## + WBC..10.9.L. 1 0.112 523.43 268.00
## - Phenylethylamine 1 7.084 530.62 268.01
## + Dopa 1 0.109 523.43 268.01
## + TC..mM. 1 0.098 523.44 268.01
## + Enterolactone 1 0.087 523.45 268.02
## + Sphingosine.1.phosphate 1 0.053 523.48 268.04
## + X4.Hydroxybenzoic.acid 1 0.051 523.49 268.04
## + Oleoylethanolamide 1 0.049 523.49 268.04
## + Phenylacetic.acid 1 0.042 523.50 268.04
## + Palmitic.amide 1 0.040 523.50 268.05
## + Putrescine 1 0.027 523.51 268.05
## + Stearoylethanolamide 1 0.024 523.51 268.05
## + Υ.GT..U.L. 1 0.016 523.52 268.06
## + BASO.... 1 0.007 523.53 268.06
## + Urea..mM. 1 0.005 523.53 268.06
## + X4.Ethylphenyl.sulfate 1 0.002 523.54 268.07
## + UA..uM. 1 0.001 523.54 268.07
## + S.gosine.1.phosphate_b 1 0.000 523.54 268.07
## - Phenyllactate 1 7.639 531.18 268.31
## - Oleamide 1 7.796 531.33 268.40
## - Salicylic.acid 1 8.351 531.89 268.70
## - Octadecanamide 1 8.664 532.20 268.88
## - Xanthurenic.acid 1 8.721 532.26 268.91
## - Bilirubin.1 1 9.743 533.28 269.47
## - N.Acetylcadaverine 1 9.753 533.29 269.48
## - X3.Hydroxyhippuric.acid 1 9.924 533.46 269.57
## - Phenylacetylglutamine.PAGln. 1 10.186 533.72 269.71
## - Indoxyl.sulfate 1 10.380 533.92 269.82
## - Gamma.aminobutyric.acid 1 10.886 534.42 270.10
## - D.BIL..uM. 1 11.261 534.80 270.30
## - T.BIL..uM. 1 12.791 536.33 271.14
## - X3.Hydroxyanthranilic.acid 1 12.807 536.34 271.15
## - Phenyl.sulfate 1 13.206 536.74 271.37
## - X5.Aminopentanoic.acid 1 15.070 538.61 272.38
## - Indole.3.carboxaldehyde 1 15.173 538.71 272.44
## - p.Cresol.sulfate 1 16.917 540.45 273.39
## - Ascorbic.acid 1 16.959 540.50 273.41
## - Pantothenol 1 17.921 541.46 273.93
## - S.ganine.1.phosphate_b 1 18.283 541.82 274.12
## - AST..U.L. 1 20.622 544.16 275.39
## - X3.Hydroxypropionic.acid 1 23.211 546.75 276.78
## - X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid 1 25.864 549.40 278.20
## - Acetylglycine 1 27.548 551.09 279.09
## - Kynurenic.acid 1 28.723 552.26 279.72
## - Sphinganine 1 32.098 555.63 281.50
## - Indole.3.methyl.acetate 1 32.618 556.16 281.78
## - X1.5.Anhydrosorbitol 1 34.945 558.48 283.00
## - ALT..U.L. 1 37.874 561.41 284.53
## - HDL.C..mM. 1 38.095 561.63 284.65
## - Indole.3.acrylic.acid 1 54.346 577.88 293.00
## - Palmitoylethanolamide 1 59.587 583.12 295.65
## - X3.Indolebutyric.acid 1 60.700 584.24 296.21
## - TG..mM. 1 86.843 610.38 309.04## [1] "(Intercept)"
## [2] "ALT..U.L."
## [3] "AST..U.L."
## [4] "ALB..g.L."
## [5] "TG..mM."
## [6] "HDL.C..mM."
## [7] "T.BIL..uM."
## [8] "D.BIL..uM."
## [9] "NEUT...."
## [10] "LYMPH...."
## [11] "Phenylethylamine"
## [12] "Octadecanamide"
## [13] "Imidazolepropionic.acid"
## [14] "Indole.3.carboxaldehyde"
## [15] "X3.Hydroxyanthranilic.acid"
## [16] "Oleamide"
## [17] "Palmitoylethanolamide"
## [18] "Bilirubin"
## [19] "Indole.3.acrylic.acid"
## [20] "Kynurenic.acid"
## [21] "Indole.3.methyl.acetate"
## [22] "Sphinganine"
## [23] "Sphinganine.1.phosphate"
## [24] "X3.Indolebutyric.acid"
## [25] "Phenylacetylglutamine.PAGln."
## [26] "Pantothenol"
## [27] "Gamma.aminobutyric.acid"
## [28] "X5.Aminopentanoic.acid"
## [29] "N.Acetylcadaverine"
## [30] "N8.Acetylspermidine"
## [31] "X1.5.Anhydrosorbitol"
## [32] "Salicylic.acid"
## [33] "Phenyllactate"
## [34] "Bilirubin.1"
## [35] "X3..3.Hydroxyphenyl..3.hydroxypropanoic.acid"
## [36] "p.Cresol.sulfate"
## [37] "X2.Hydroxy.Hippuric.Acid"
## [38] "X3.Hydroxyhippuric.acid"
## [39] "S.ganine.1.phosphate_b"
## [40] "Cholesterol.sulfate"
## [41] "Xanthurenic.acid"
## [42] "Cinnamoylglycine"
## [43] "Indoxyl.sulfate"
## [44] "Ascorbic.acid"
## [45] "Homovanillic.acid.sulfate"
## [46] "Phenyl.sulfate"
## [47] "X3.Hydroxypropionic.acid"
## [48] "Acetylglycine"Bboth <- Basecom %>% select("ALT (U/L)", "AST (U/L)", "ALB (g/L)", "TG (mM)", "HDL-C (mM)", "T-BIL (uM)", "D-BIL (uM)", "NEUT (%)", "LYMPH (%)", "Phenylethylamine")
# vector de medias
center4 <- colMeans(Bboth)
# matriz de covarianza
cov_matrix4 <- cov(Bboth)
#distancia de mahalanobis
dist_mahal_Bboth <- mahalanobis(Bboth, center4, cov_matrix4)
# Distancias
boxplot(dist_mahal_Bboth,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbralBboth <- qchisq(0.95, df = ncol(Bboth))
#outliers
outliersBboth <- which(dist_mahal_Bboth > umbralBboth)
#Gráfico
plot(dist_mahal_Bboth, pch = 19, col = "steelblue",
main = "Distancia de Mahalanobis, biomarcadores stepwise (both)",
ylab = "D²", xlab = "Observación")
abline(h = umbralBboth, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliersBboth, dist_mahal_Bboth[outliersBboth],
labels = outliersBboth, pos = 3, col = "red")
DM Bboth escalada por sd
# DM estandarizada usando la desviación estándar
dist_mahal_sdBboth <- dist_mahal_Bboth / sd(dist_mahal_Bboth)
#Distancias
boxplot(dist_mahal_sdBboth,
main = "Distancia de Mahalanobis estandarizada",
ylab = "DM / SD(DM)",
col = "lightblue")
#95IC
umbralBboth <- qchisq(0.95, df = ncol(Bboth))
umbral_sd <- umbralBboth / sd(dist_mahal_Bboth)
#outliers
outliers_sd <- which(dist_mahal_sdBboth > umbral_sd)
#Gráfico
plot(dist_mahal_sdBboth,pch = 19, col = "steelblue",
main = "DM, biomarcadores stepwise (both) estandarizada por sd",
ylab = "DM / SD(DM)", xlab = "Observación")
abline(h = umbral_sd, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliers_sd, dist_mahal_sdBboth[outliers_sd],
labels = outliers_sd, pos = 3, col = "red")
Log base 10 de la DM Bboth
# Log base 10 de la DM
dist_mahal_log10Bboth <- log10(dist_mahal_Bboth)
boxplot(dist_mahal_log10Bboth,
main = "Log10 de la Distancia de Mahalanobis",
ylab = "log10(D²)",
col = "lightblue")
plot(dist_mahal_log10Bboth,
pch = 19,
col = "steelblue",
main = "Log10 de la DM, biomarcadores stepwise (both)",
ylab = "log10(D²)",
xlab = "Observación")
Log n de la DM Bboth
# Log natural de la DM
dist_mahal_logBboth <- log(dist_mahal_Bboth)
boxplot(dist_mahal_logBboth,
main = "Log n de la DM, biomarcadores stepwise (both)",
ylab = "log n(D²)",
col = "lightblue")
plot(dist_mahal_logBboth,
pch = 19,
col = "steelblue",
main = "Log natural de la Distancia de Mahalanobis",
ylab = "log n(D²)",
xlab = "Observación")
Distancias de mahalanobis - 20 biomarcadores con mayor varianza base completa
#BAse completa
Bcom3 <- Basecom %>% select(14:ncol(Basecom))
# Varianza de cada columna
varianzas <- sapply(Bcom3, function(x) {
if (is.numeric(x)) var(x, na.rm = TRUE) else NA
})
# Convertir a df
varianzas_df <- data.frame(
Variable = names(varianzas),
Varianza = varianzas
) %>%
arrange(desc(Varianza)) %>%
na.omit()
# Mostrar las primeras 20
head(varianzas_df, 21)Bcom3_20 <- Basecom %>%
select("Putrescine", "Bilirubin", "Gamma-aminobutyric acid",
"4-Ethylphenyl sulfate", "Phenol", "Ascorbic acid", "p-Cresol",
"3-Hydroxyphenylacetic acid", "1,5-Anhydrosorbitol", "Phenyl sulfate",
"5-Aminopentanoic acid", "Indole-3-propionic acid", "p-Cresol sulfate",
"Cholesterol sulfate", "Oleamide", "Hippuric acid", "Indoxyl sulfate",
"3-Hydroxypropionic acid", "UA (uM)", "CHE (U/L)")
# vector de medias
center5 <- colMeans(Bcom3_20)
# matriz de covarianza
cov_matrix5 <- cov(Bcom3_20)
#distancia de mahalanobis
dist_mahal_20mvar_Bcom <- mahalanobis(Bcom3_20, center5, cov_matrix5)
# Distancias
boxplot(dist_mahal_20mvar_Bcom,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbral20mv <- qchisq(0.95, df = ncol(Bcom3_20))
#outliers
outliers20mv <- which(dist_mahal_20mvar_Bcom > umbral20mv)
#Gráfico
plot(dist_mahal_20mvar_Bcom, pch = 19, col = "steelblue",
main = "Distancia de Mahalanobis, biomarcadores con mayor varianza",
ylab = "D²", xlab = "Observación")
abline(h = umbral20mv, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliers20mv, dist_mahal_20mvar_Bcom[outliers20mv],
labels = outliers20mv, pos = 3, col = "red")
Distancias de Mahalanobis - 20 biomarcadores con menor correlación
# Menor correlación
# matriz correlación
corr_matrix <- cor(Bcom, use = "pairwise.complete.obs")
#promedio de correlación
prom_corr <- apply(abs(corr_matrix), 2, mean, na.rm = TRUE)
# ordenar
prom_corr_sorted <- sort(prom_corr)
#mostrar las primeras
top20_independientes <- head(prom_corr_sorted, 20)
top20_independientes## Enterolactone
## 0.04705696
## Phenyl sulfate
## 0.05144838
## BASO (%)
## 0.05624737
## EO (%)
## 0.05760976
## Urocanic acid
## 0.06519472
## NEUT (%)
## 0.06696144
## 3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid
## 0.06867079
## Benzoic acid
## 0.06910998
## Oleamide
## 0.06950296
## 3-Hydroxybenzoic acid
## 0.07018885
## Spermine
## 0.07129736
## TC (mM)
## 0.07137069
## 4-Ethylphenyl sulfate
## 0.07296719
## N8-Acetylspermidine
## 0.07633866
## Homovanillic acid sulfate
## 0.07705457
## Iodide
## 0.07748540
## Dopamine
## 0.07800140
## Palmitic amide
## 0.07984195
## 3-Hydroxyhippuric acid
## 0.07988819
## Hippuric acid
## 0.07989241# Menor correlación
M20mc <- Basecom %>%
select("Enterolactone", "Phenyl sulfate", "Spermine", "Urocanic acid",
"3-Hydroxybenzoic acid", "3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid",
"Oleamide", "Benzoic acid", "4-Ethylphenyl sulfate", "Iodide",
"3-Hydroxyphenylacetic acid", "N8-Acetylspermidine", "Homovanillic acid sulfate",
"3-Indolebutyric acid", "Palmitic amide", "2-Hydroxy Hippuric Acid",
"Hippuric acid", "Phenylethylamine", "Phenol", "Salicylic acid")
# vector de medias
center5 <- colMeans(M20mc)
# matriz de covarianza
cov_matrix5 <- cov(M20mc)
#distancia de mahalanobis
dist_mahal_20menor_cor <- mahalanobis(M20mc, center5, cov_matrix5)
# Distancias
boxplot(dist_mahal_20menor_cor,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbral20mc <- qchisq(0.95, df = ncol(M20mc))
#outliers
outliers20mc <- which(dist_mahal_20menor_cor > umbral20mc)
#Gráfico
plot(dist_mahal_20menor_cor, pch = 19, col = "steelblue",
main = "DM, biomarcadores con menor correlación",
ylab = "D²", xlab = "Observación")
abline(h = umbral20mc, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliers20mc, dist_mahal_20menor_cor[outliers20mc],
labels = outliers20mc, pos = 3, col = "red")
Distancias de Mahalanobis - 20 con menor correlación y mayor varianza
# matriz cor
corr_matrix <- cor(Bcom, use = "pairwise.complete.obs")
# valor abs de cada cor
prom_corr <- apply(abs(corr_matrix), 1, mean, na.rm = TRUE)
# varianza de cada variable
varianzas <- sapply(Bcom, function(x) var(as.numeric(x), na.rm = TRUE))
# combinar en un df
summary_df <- data.frame(
Variable = names(prom_corr),
Prom_Corr = prom_corr,
Varianza = varianzas
)
# ordenar con menor correlación promedio y mayor varianza
summary_df <- summary_df[order(summary_df$Prom_Corr, -summary_df$Varianza), ]
#primerqas 20
head(summary_df, 40)# Menor correlación y mayor varianza
M20mcmv <- Basecom %>%
select("Phenyl sulfate", "Spermine", "Urocanic acid",
"3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid",
"Oleamide", "Benzoic acid", "4-Ethylphenyl sulfate", "Iodide",
"3-Hydroxyphenylacetic acid", "N8-Acetylspermidine",
"Homovanillic acid sulfate",
"Palmitic amide", "2-Hydroxy Hippuric Acid",
"Hippuric acid", "Phenol", "Salicylic acid", "Dopamine",
"3-Hydroxyhippuric acid",
"4-Hydroxybenzoic acid", "Gamma-aminobutyric acid")
# vector de medias
center6 <- colMeans(M20mcmv)
# matriz de covarianza
cov_matrix6 <- cov(M20mcmv)
#distancia de mahalanobis
dist_mahal_20menorcor_mayorvar <- mahalanobis(M20mcmv, center6,
cov_matrix6)
# Distancias
boxplot(dist_mahal_20menorcor_mayorvar,
main = "Distancia de Mahalanobis",
ylab = "D² (desviaciones multivariadas)",
col = "lightblue")
#95IC
umbral20mcmv <- qchisq(0.95, df = ncol(M20mcmv))
#outliers
outliers20mcmv <- which(dist_mahal_20menorcor_mayorvar > umbral20mcmv)
#Gráfico
plot(dist_mahal_20menorcor_mayorvar, pch = 19, col = "steelblue",
main = "DM, biomarcadores con menor correlación y mayor varianza",
ylab = "D²", xlab = "Observación")
abline(h = umbral20mcmv, col = "red", lwd = 2, lty = 2)
#Etiquetas para los outliers
text(outliers20mcmv, dist_mahal_20menorcor_mayorvar[outliers20mcmv],
labels = outliers20mcmv, pos = 3, col = "red")
Tabla 2
# Convertir variable dependiente en binaria
Basecom <- Basecom %>%
mutate(Group_bin = ifelse(Group == 1, 1, 0))
# Lista de distancias
dist_vars <- list(
DM_Bline = dist_mahal_bline,
DM_M4 = dist_mahal_M1,
DM_Bcom = dist_mahal_Bcom,
DM_Bboth = dist_mahal_Bboth,
DM_Bbothsd = dist_mahal_sdBboth,
DM_Bboth_log10 = dist_mahal_log10Bboth,
DM_Bboth_log = dist_mahal_logBboth,
DM_20mvar_com = dist_mahal_20mvar_Bcom,
DM_20menor_cor = dist_mahal_20menor_cor,
DM_20menorcor_mayorvar = dist_mahal_20menorcor_mayorvar
)
# Guardar resultados
resultados <- list()
#
for (nombre in names(dist_vars)) {
# Extraer vector
dist <- as.numeric(dist_vars[[nombre]])
# Dataframe temporal
datos_modelo <- data.frame(
Group_bin = Basecom$Group_bin,
dist = dist
)
# Modelo
modelo <- glm(Group_bin ~ dist,
data = datos_modelo,
family = binomial())
# Resumen
beta <- coef(modelo)[2]
OR <- exp(beta)
# IC 95%
conf <- exp(confint.default(modelo))
# AIC y BIC
AIC_val <- AIC(modelo)
BIC_val <- BIC(modelo)
# Tabla parcial
resultado <- tibble(
Predictor = nombre,
Beta = round(beta, 4),
OR = round(OR, 4),
`IC 95% Inferior` = round(conf[2, 1], 4),
`IC 95% Superior` = round(conf[2, 2], 4),
`Valor p` = as.character(
ifelse(coef(summary(modelo))[2, 4] < 0.0001,
"<0.0001",
round(coef(summary(modelo))[2, 4], 4))
),
AIC = round(AIC_val, 2),
BIC = round(BIC_val, 2)
)
resultados[[nombre]] <- resultado
}
# Unir resultados
tabla_mahalanobis <- bind_rows(resultados)
# Mostrar tabla
tabla_mahalanobis %>%
kable(
format = "html",
caption = "Tabla 2: Relación entre las distancias de Mahalanobis y la condición diabetes"
) %>%
kable_styling(
bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center"
)| Predictor | Beta | OR | IC 95% Inferior | IC 95% Superior | Valor p | AIC | BIC |
|---|---|---|---|---|---|---|---|
| DM_Bline | 0.0143 | 1.0144 | 1.0005 | 1.0285 | 0.0422 | 370.79 | 378.15 |
| DM_M4 | 0.0079 | 1.0079 | 1.0018 | 1.0140 | 0.0113 | 369.38 | 376.74 |
| DM_Bcom | 0.0101 | 1.0102 | 1.0041 | 1.0163 | 0.001 | 364.47 | 371.83 |
| DM_Bboth | 0.0471 | 1.0482 | 1.0215 | 1.0756 | 3e-04 | 357.11 | 364.47 |
| DM_Bbothsd | 0.7758 | 2.1722 | 1.4199 | 3.3232 | 3e-04 | 357.11 | 364.47 |
| DM_Bboth_log10 | 1.7298 | 5.6394 | 2.7609 | 11.5188 | <0.0001 | 350.81 | 358.17 |
| DM_Bboth_log | 0.7512 | 2.1196 | 1.5543 | 2.8904 | <0.0001 | 350.81 | 358.17 |
| DM_20mvar_com | 0.0174 | 1.0176 | 1.0031 | 1.0323 | 0.0175 | 369.06 | 376.42 |
| DM_20menor_cor | 0.0066 | 1.0066 | 0.9994 | 1.0138 | 0.0718 | 372.69 | 380.05 |
| DM_20menorcor_mayorvar | 0.0098 | 1.0099 | 1.0020 | 1.0178 | 0.014 | 368.80 | 376.16 |
Tabla 2 ajustada por edad y sexo
#Cambiar Gender de texto a factor
Basecom$sex <- as.factor(Basecom$Gender)
#Tabla 2 ajustada por edad y sexo
for (nombre in names(dist_vars)) {
dist <- as.numeric(dist_vars[[nombre]])
datos_modelo <- data.frame(
Group_bin = Basecom$Group_bin,
dist = dist,
Age = Basecom$Age,
Gender = Basecom$Gender
)
modelo <- glm(
Group_bin ~ dist + Age + Gender,
data = datos_modelo,
family = binomial()
)
beta <- coef(modelo)["dist"]
OR <- exp(beta)
conf <- exp(confint.default(modelo))
AIC_val <- AIC(modelo)
BIC_val <- BIC(modelo)
resultado <- tibble(
Predictor = nombre,
Beta = round(beta, 4),
OR = round(OR, 4),
`IC 95% Inferior` = round(conf["dist", 1], 4),
`IC 95% Superior` = round(conf["dist", 2], 4),
`Valor p` = as.character(
ifelse(summary(modelo)$coefficients["dist", 4] < 0.0001,
"<0.0001",
round(summary(modelo)$coefficients["dist", 4], 4))
),
AIC = round(AIC_val, 2),
BIC = round(BIC_val, 2)
)
resultados[[nombre]] <- resultado
}
# Unir resultados
tabla_mahalanobis_ajustada <- bind_rows(resultados)
# Mostrar tabla
tabla_mahalanobis_ajustada %>%
kable(
format = "html",
caption = "Tabla 2: Relación entre las distancias de Mahalanobis y la condición diabetes, ajustada por edad y sexo"
) %>%
kable_styling(
bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center"
)| Predictor | Beta | OR | IC 95% Inferior | IC 95% Superior | Valor p | AIC | BIC |
|---|---|---|---|---|---|---|---|
| DM_Bline | 0.0122 | 1.0122 | 0.9998 | 1.0248 | 0.0532 | 362.06 | 376.78 |
| DM_M4 | 0.0069 | 1.0069 | 1.0006 | 1.0132 | 0.0314 | 361.69 | 376.41 |
| DM_Bcom | 0.0091 | 1.0092 | 1.0030 | 1.0154 | 0.0035 | 357.53 | 372.25 |
| DM_Bboth | 0.0448 | 1.0458 | 1.0188 | 1.0736 | 8e-04 | 350.60 | 365.32 |
| DM_Bbothsd | 0.7388 | 2.0933 | 1.3591 | 3.2243 | 8e-04 | 350.60 | 365.32 |
| DM_Bboth_log10 | 1.6622 | 5.2711 | 2.5375 | 10.9497 | <0.0001 | 344.42 | 359.14 |
| DM_Bboth_log | 0.7219 | 2.0583 | 1.4984 | 2.8275 | <0.0001 | 344.42 | 359.14 |
| DM_20mvar_com | 0.0174 | 1.0175 | 1.0029 | 1.0323 | 0.0184 | 359.44 | 374.16 |
| DM_20menor_cor | 0.0057 | 1.0058 | 0.9984 | 1.0132 | 0.1257 | 364.07 | 378.79 |
| DM_20menorcor_mayorvar | 0.0084 | 1.0084 | 1.0004 | 1.0165 | 0.039 | 361.51 | 376.23 |
Tabla 2 ajustada por edad, sexo, peso y SBP
#Tabla 2 ajustada por edad, sexo, peso y SBP
for (nombre in names(dist_vars)) {
dist <- as.numeric(dist_vars[[nombre]])
datos_modelo <- data.frame(
Group_bin = Basecom$Group_bin,
dist = dist,
Age = Basecom$Age,
Gender = Basecom$Gender,
Weight = Basecom$Weight,
SBP = Basecom$`SBP (mmHg)`
)
modelo <- glm(
Group_bin ~ dist + Age + Gender + Weight + SBP,
data = datos_modelo,
family = binomial()
)
beta <- coef(modelo)["dist"]
OR <- exp(beta)
conf <- exp(confint.default(modelo))
AIC_val <- AIC(modelo)
BIC_val <- BIC(modelo)
resultado <- tibble(
Predictor = nombre,
Beta = round(beta, 4),
OR = round(OR, 4),
`IC 95% Inferior` = round(conf["dist", 1], 4),
`IC 95% Superior` = round(conf["dist", 2], 4),
`Valor p` = as.character(
ifelse(summary(modelo)$coefficients["dist", 4] < 0.0001,
"<0.0001",
round(summary(modelo)$coefficients["dist", 4], 4))
),
AIC = round(AIC_val, 2),
BIC = round(BIC_val, 2)
)
resultados[[nombre]] <- resultado
}
# Unir resultados
tabla_mahalanobis_ajustada <- bind_rows(resultados)
# Mostrar tabla
tabla_mahalanobis_ajustada %>%
kable(
format = "html",
caption = "Tabla 2: Relación entre las distancias de Mahalanobis y la condición diabetes, ajustada por edad, sexo, peso y SBP"
) %>%
kable_styling(
bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center"
)| Predictor | Beta | OR | IC 95% Inferior | IC 95% Superior | Valor p | AIC | BIC |
|---|---|---|---|---|---|---|---|
| DM_Bline | 0.0078 | 1.0078 | 0.9962 | 1.0195 | 0.1875 | 308.52 | 330.60 |
| DM_M4 | 0.0074 | 1.0074 | 1.0007 | 1.0141 | 0.03 | 305.46 | 327.54 |
| DM_Bcom | 0.0089 | 1.0089 | 1.0024 | 1.0155 | 0.007 | 302.81 | 324.89 |
| DM_Bboth | 0.0303 | 1.0308 | 1.0045 | 1.0578 | 0.0214 | 301.39 | 323.47 |
| DM_Bbothsd | 0.4999 | 1.6486 | 1.0770 | 2.5237 | 0.0214 | 301.39 | 323.47 |
| DM_Bboth_log10 | 1.3971 | 4.0434 | 1.8460 | 8.8564 | 5e-04 | 297.11 | 319.19 |
| DM_Bboth_log | 0.6067 | 1.8344 | 1.3050 | 2.5786 | 5e-04 | 297.11 | 319.19 |
| DM_20mvar_com | 0.0240 | 1.0243 | 1.0062 | 1.0426 | 0.0082 | 301.89 | 323.97 |
| DM_20menor_cor | 0.0066 | 1.0066 | 0.9986 | 1.0147 | 0.1075 | 307.61 | 329.69 |
| DM_20menorcor_mayorvar | 0.0079 | 1.0079 | 0.9997 | 1.0162 | 0.0595 | 306.20 | 328.28 |
Tabla 2 ajustada por edad, sexo, peso, SBP y glucosa
#Tabla 2 ajustada por edad, sexo, peso, SBP y glucosa
for (nombre in names(dist_vars)) {
dist <- as.numeric(dist_vars[[nombre]])
datos_modelo <- data.frame(
Group_bin = Basecom$Group_bin,
dist = dist,
Age = Basecom$Age,
Gender = Basecom$Gender,
Weight = Basecom$Weight,
SBP = Basecom$`SBP (mmHg)`,
FBG = Basecom$`FBG (mM)`
)
modelo <- glm(
Group_bin ~ dist + Age + Gender + Weight + SBP + FBG,
data = datos_modelo,
family = binomial()
)
beta <- coef(modelo)["dist"]
OR <- exp(beta)
conf <- exp(confint.default(modelo))
AIC_val <- AIC(modelo)
BIC_val <- BIC(modelo)
resultado <- tibble(
Predictor = nombre,
Beta = round(beta, 4),
OR = round(OR, 4),
`IC 95% Inferior` = round(conf["dist", 1], 4),
`IC 95% Superior` = round(conf["dist", 2], 4),
`Valor p` = as.character(
ifelse(summary(modelo)$coefficients["dist", 4] < 0.0001,
"<0.0001",
round(summary(modelo)$coefficients["dist", 4], 4))
),
AIC = round(AIC_val, 2),
BIC = round(BIC_val, 2)
)
resultados[[nombre]] <- resultado
}## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred## Warning: glm.fit: algorithm did not converge## Warning: glm.fit: fitted probabilities numerically 0 or 1 occurred# Unir resultados
tabla_mahalanobis_ajustada <- bind_rows(resultados)
# Mostrar tabla
tabla_mahalanobis_ajustada %>%
kable(
format = "html",
caption = "Tabla 2: Relación entre las distancias de Mahalanobis y la condición diabetes, ajustada por edad, sexo, peso, SBP y glucosa"
) %>%
kable_styling(
bootstrap_options = c("striped", "hover", "condensed"),
full_width = FALSE,
position = "center"
)| Predictor | Beta | OR | IC 95% Inferior | IC 95% Superior | Valor p | AIC | BIC |
|---|---|---|---|---|---|---|---|
| DM_Bline | 0.0733 | 1.076000e+00 | 0 | 2.533184e+71 | 0.9993 | 14 | 39.76 |
| DM_M4 | 0.0539 | 1.055400e+00 | 0 | 7.101017e+83 | 0.9996 | 14 | 39.76 |
| DM_Bcom | 0.0648 | 1.067000e+00 | 0 | 1.871708e+82 | 0.9995 | 14 | 39.76 |
| DM_Bboth | 0.6613 | 1.937400e+00 | 0 | Inf | 0.9992 | 14 | 39.76 |
| DM_Bbothsd | 10.9035 | 5.436411e+04 | 0 | Inf | 0.9992 | 14 | 39.76 |
| DM_Bboth_log10 | 29.1393 | 4.519114e+12 | 0 | Inf | 0.9994 | 14 | 39.76 |
| DM_Bboth_log | 12.6551 | 3.133429e+05 | 0 | Inf | 0.9994 | 14 | 39.76 |
| DM_20mvar_com | -0.1599 | 8.522000e-01 | 0 | Inf | 0.9997 | 14 | 39.76 |
| DM_20menor_cor | 0.2107 | 1.234500e+00 | 0 | 6.177617e+136 | 0.999 | 14 | 39.76 |
| DM_20menorcor_mayorvar | 0.2443 | 1.276800e+00 | 0 | 3.646581e+156 | 0.9989 | 14 | 39.76 |