II (N=19)	Retro (N=55)	P-value
TMB
High	8 (42.1%)	25 (45.5%)	1
Low	10 (52.6%)	30 (54.5%)
Missing	1 (5.3%)	0 (0%)
TRT
0	2 (10.5%)	31 (56.4%)	0.00139
1	17 (89.5%)	24 (43.6%)
Sex
Female	4 (21.1%)	10 (18.2%)	1
Male	15 (78.9%)	45 (81.8%)
Smoking
Never smoking	4 (21.1%)	20 (36.4%)	0.345
Smoking	15 (78.9%)	35 (63.6%)
Brain.metastases
No	17 (89.5%)	43 (78.2%)	0.457
Yes	2 (10.5%)	12 (21.8%)
Bone.metastases
No	15 (78.9%)	42 (76.4%)	1
Yes	4 (21.1%)	13 (23.6%)
Liver.metastases
No	11 (57.9%)	40 (72.7%)	0.359
Yes	8 (42.1%)	15 (27.3%)
Adrenal.metastases
No	17 (89.5%)	46 (83.6%)	0.808
Yes	2 (10.5%)	9 (16.4%)
Distant.lymph.node
No	16 (84.2%)	36 (65.5%)	0.211
Yes	3 (15.8%)	19 (34.5%)
Stage
III	1 (5.3%)	2 (3.6%)	1
IV	18 (94.7%)	53 (96.4%)
CI.cycle
4	4 (21.1%)	3 (5.5%)	0.171
5	1 (5.3%)	8 (14.5%)
6	14 (73.7%)	43 (78.2%)
7	0 (0%)	1 (1.8%)
clinical_benefit_12months
DCB	10 (52.6%)	12 (21.8%)	0.0602
NDB	7 (36.8%)	30 (54.5%)
Missing	2 (10.5%)	13 (23.6%)