This database includes 710 RCTs from 46 countries published by 3811 researchers between 1986 and 2026.
Most, 580 (82%), are single-centred. The median (IQR) number of centres in the 130 multi-centred trials was 5 (2, 12.8) min=2 max=104.
The median (IQR) number of children in individually randomized trials was 61 (40, 106.8) min=6 max=2040 and 1523 (383.8, 3081) min=97 max=11661 in the 12 cluster randomized trials.
| Year | RCTs |
|---|---|
| 2026 | 14 |
| 2025 | 32 |
| 2024 | 21 |
| 2023 | 40 |
| 2022 | 32 |
| 2021 | 55 |
| 2020 | 49 |
| 2019 | 25 |
| 2018 | 41 |
| 2017 | 35 |
| 2016 | 25 |
| 2015 | 34 |
| 2014 | 21 |
| 2013 | 29 |
| 2012 | 26 |
| 2011 | 16 |
| 2010 | 11 |
| 2009 | 18 |
| 2008 | 13 |
| 2007 | 19 |
| 2006 | 10 |
| 2005 | 21 |
| 2004 | 8 |
| 2003 | 13 |
| 2002 | 17 |
| 2001 | 13 |
| 2000 | 8 |
| 1999 | 12 |
| 1998 | 7 |
| 1997 | 10 |
| 1996 | 9 |
| 1995 | 1 |
| 1994 | 5 |
| 1993 | 4 |
| 1992 | 4 |
| 1991 | 4 |
| 1990 | 2 |
| 1989 | 2 |
| 1988 | 2 |
| 1987 | 1 |
| 1986 | 1 |
| Country | RCTs | Children randomized |
|---|---|---|
| United States | 158 | 31757 |
| India | 99 | 10277 |
| China | 76 | 7545 |
| Egypt | 38 | 3214 |
| Brazil | 36 | 4718 |
| Iran | 30 | 2127 |
| Turkey | 30 | 2782 |
| Canada | 23 | 1851 |
| United Kingdom | 23 | 20657 |
| Australia | 22 | 4664 |
| The Netherlands | 20 | 2047 |
| Germany | 15 | 1950 |
| Italy | 15 | 695 |
| Spain | 15 | 1690 |
| Thailand | 14 | 1074 |
| Japan | 9 | 592 |
| France | 8 | 651 |
| Argentina | 7 | 2568 |
| Russia | 7 | 327 |
| Belgium | 5 | 2302 |
| Chile | 5 | 264 |
| Greece | 5 | 187 |
| Indonesia | 5 | 518 |
| Pakistan | 4 | 413 |
| Saudi Arabia | 4 | 349 |
| Switzerland | 4 | 190 |
| Vietnam | 4 | 196 |
| Austria | 3 | 102 |
| Israel | 3 | 357 |
| South Africa | 3 | 129 |
| Croatia | 2 | 46 |
| Cuba | 2 | 73 |
| Finland | 2 | 202 |
| South Korea | 2 | 166 |
| Bangladesh | 1 | 225 |
| Colombia | 1 | 92 |
| Malaysia | 1 | 30 |
| Mexico | 1 | 14 |
| New Zealand | 1 | 55 |
| Philippines | 1 | 27 |
| Poland | 1 | 41 |
| Portugal | 1 | 268 |
| Sweden | 1 | 72 |
| Taiwan | 1 | 60 |
| Tunisa | 1 | 255 |
| Ukraine | 1 | 20 |
Searches and data extraction (in duplicate) were updated quarterly until 2022Q3. After that I’ve added trials I’ve become aware of and extracted a minimal dataset.
See https://dx.doi.org/10.1186/cc13083 for methods and more information and https://www.zotero.org/groups/1345589/picutrials/library for the full list of trials.
Please send me trials I’ve missed or full-texts I don’t have access to so I can add them. Contact Mark Duffett (duffett@hhsc.ca or mark.duffett@gmail.com) for more information.