This database includes 710 RCTs from 46 countries published by 3811 researchers between 1986 and 2026.

Most, 580 (82%), are single-centred. The median (IQR) number of centres in the 130 multi-centred trials was 5 (2, 12.8) min=2 max=104.

The median (IQR) number of children in individually randomized trials was 61 (40, 106.8) min=6 max=2040 and 1523 (383.8, 3081) min=97 max=11661 in the 12 cluster randomized trials.

RCTs per year
RCTs per year (cumulative)
Multicentre RCTs per year (cumulative)
Children randomized per year (cumulative)
RCTs per country
RCTs per country (detail)
RCTs per country per decade
Children randomized per country per decade
Sample size over time
Sample size over time

Searches and data extraction (in duplicate) were updated quarterly until 2022Q3. After that I’ve added trials I’ve become aware of and extracted a minimal dataset.

See https://dx.doi.org/10.1186/cc13083 for methods and more information and https://www.zotero.org/groups/1345589/picutrials/library for the full list of trials.

Please send me trials I’ve missed or full-texts I don’t have access to so I can add them. Contact Mark Duffett (duffett@hhsc.ca or mark.duffett@gmail.com) for more information.