CBFS short

#sample size now uses latest diagnosis. It is based on the LAST visit and SECOND TO LAST

Restricted to complete data across all outcomes.

Sample size

Not_CU

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
FTLDCDR_SB	304	1.806	2.721	30% reduction	1.265	395.718	0.995	0.504	1.493
CBS_TOTAL_SCORE	304	6.899	12.988	30% reduction	4.83	618.057	0.995	0.504	1.493
PSPRS_TOTAL	304	4.013	7.784	30% reduction	2.809	656.177	0.995	0.504	1.493
CBS_MOTOR_SCORE	304	2.934	6.154	30% reduction	2.054	767.032	0.995	0.504	1.493
CBS_LCB_SCORE	304	3.059	6.724	30% reduction	2.142	842.594	0.995	0.504	1.493
UPDRS_SCORE	304	3.482	8.319	30% reduction	2.437	995.642	0.995	0.504	1.493
CBS_NONMOTOR_SCORE	304	0.906	3.155	30% reduction	0.634	2116.689	0.995	0.504	1.493

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CBSorPSPorNFVPPSorALS

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
FTLDCDR_SB	66	1.273	1.789	30% reduction	0.891	344.413	1.022	0.518	1.493
CBS_MOTOR_SCORE	66	3.484	6.025	30% reduction	2.439	521.543	1.022	0.518	1.493
PSPRS_TOTAL	66	4.035	7.726	30% reduction	2.824	639.555	1.022	0.518	1.493
CBS_TOTAL_SCORE	66	6.563	12.746	30% reduction	4.594	657.8	1.022	0.518	1.493
UPDRS_SCORE	66	4.144	9.246	30% reduction	2.901	868.499	1.022	0.518	1.493
CBS_NONMOTOR_SCORE	66	0.9	2.65	30% reduction	0.63	1512.737	1.022	0.518	1.493
CBS_LCB_SCORE	66	2.18	6.748	30% reduction	1.526	1671.79	1.022	0.518	1.493

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CBS

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
PSPRS_TOTAL	18	9.518	8.874	30% reduction	6.663	151.617	0.889	0.518	1.208
CBS_MOTOR_SCORE	18	6.485	6.115	30% reduction	4.539	155.095	0.889	0.518	1.208
FTLDCDR_SB	18	2.187	2.29	30% reduction	1.531	191.316	0.889	0.518	1.208
CBS_TOTAL_SCORE	18	8.925	10.58	30% reduction	6.248	245.109	0.889	0.518	1.208
UPDRS_SCORE	18	9.923	12.492	30% reduction	6.946	276.451	0.889	0.518	1.208
CBS_NONMOTOR_SCORE	18	1.144	3.476	30% reduction	0.801	1610.451	0.889	0.518	1.208
CBS_LCB_SCORE	18	1.297	4.964	30% reduction	0.908	2556.469	0.889	0.518	1.208

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PSP

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
CBS_NONMOTOR_SCORE	14	2.424	2.973	30% reduction	1.697	262.39	0.868	0.562	1.115
CBS_MOTOR_SCORE	14	7.509	9.498	30% reduction	5.257	279.032	0.868	0.562	1.115
CBS_TOTAL_SCORE	14	14.691	20.146	30% reduction	10.284	328.014	0.868	0.562	1.115
UPDRS_SCORE	14	7.128	13.166	30% reduction	4.99	595.046	0.868	0.562	1.115
CBS_LCB_SCORE	14	4.757	9.453	30% reduction	3.33	688.666	0.868	0.562	1.115
PSPRS_TOTAL	14	6.666	13.755	30% reduction	4.666	742.559	0.868	0.562	1.115
FTLDCDR_SB	14	0.788	2.749	30% reduction	0.551	2123.99	0.868	0.562	1.115

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bvFTD

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
FTLDCDR_SB	44	0.909	1.262	30% reduction	0.636	336.285	1.056	0.77	1.493
CBS_TOTAL_SCORE	44	4.3	8.747	30% reduction	3.01	721.886	1.056	0.77	1.493
CBS_LCB_SCORE	44	2.664	5.54	30% reduction	1.865	754.106	1.056	0.77	1.493
CBS_NONMOTOR_SCORE	44	0.646	2.096	30% reduction	0.452	1838.033	1.056	0.77	1.493
CBS_MOTOR_SCORE	44	0.99	3.403	30% reduction	0.693	2061.975	1.056	0.77	1.493
PSPRS_TOTAL	44	0.745	3.153	30% reduction	0.521	3128.495	1.056	0.77	1.493
UPDRS_SCORE	44	0.571	3.005	30% reduction	0.4	4827.139	1.056	0.77	1.493

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nfvPPA

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
CBS_MOTOR_SCORE	18	2.264	4.41	30% reduction	1.585	661.553	1.051	0.789	1.419
FTLDCDR_SB	18	0.878	1.782	30% reduction	0.615	718.184	1.051	0.789	1.419
CBS_NONMOTOR_SCORE	18	-0.716	1.677	30% reduction	-0.501	955.59	1.051	0.789	1.419
PSPRS_TOTAL	18	2.919	6.957	30% reduction	2.044	990.614	1.051	0.789	1.419
CBS_TOTAL_SCORE	18	3.701	10.539	30% reduction	2.59	1414.713	1.051	0.789	1.419
CBS_LCB_SCORE	18	2.152	6.215	30% reduction	1.507	1454.384	1.051	0.789	1.419
UPDRS_SCORE	18	2.924	9.084	30% reduction	2.047	1682.843	1.051	0.789	1.419

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CU

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
FTLDCDR_SB	152	-0.019	0.139	30% reduction	-0.014	8875.149	1.069	0.521	1.455
UPDRS_SCORE	152	-0.052	0.466	30% reduction	-0.036	14118.226	1.069	0.521	1.455
PSPRS_TOTAL	152	-0.073	0.746	30% reduction	-0.051	18227.784	1.069	0.521	1.455
CBS_LCB_SCORE	152	-0.14	1.676	30% reduction	-0.098	25063.897	1.069	0.521	1.455
CBS_TOTAL_SCORE	152	-0.246	3.093	30% reduction	-0.172	27517.045	1.069	0.521	1.455
CBS_MOTOR_SCORE	152	-0.082	1.281	30% reduction	-0.057	42482.686	1.069	0.521	1.455
CBS_NONMOTOR_SCORE	152	-0.024	1.277	30% reduction	-0.017	477031.954	1.069	0.521	1.455

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PSPorCBS

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
CBS_MOTOR_SCORE	32	6.933	7.655	30% reduction	4.853	212.657	0.88	0.518	1.208
PSPRS_TOTAL	32	8.271	11.162	30% reduction	5.789	317.703	0.88	0.518	1.208
CBS_TOTAL_SCORE	32	11.448	15.493	30% reduction	8.013	319.481	0.88	0.518	1.208
UPDRS_SCORE	32	8.7	12.659	30% reduction	6.09	369.287	0.88	0.518	1.208
FTLDCDR_SB	32	1.575	2.558	30% reduction	1.102	460.199	0.88	0.518	1.208
CBS_NONMOTOR_SCORE	32	1.704	3.279	30% reduction	1.193	645.668	0.88	0.518	1.208
CBS_LCB_SCORE	32	2.811	7.351	30% reduction	1.968	1192.877	0.88	0.518	1.208

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CBSorbvFTDornfvPPAorPSP

Variable	N	Mean	SD	Drug_effect	Treated_Mean	Estimated_Sample_Per_Arm	Avg. Time Interval	Min Time Interval	Max Time Interval
FTLDCDR_SB	94	1.13	1.898	30% reduction	0.791	492.126	0.995	0.518	1.493
CBS_MOTOR_SCORE	94	3.257	5.976	30% reduction	2.28	587.236	0.995	0.518	1.493
CBS_TOTAL_SCORE	94	6.618	12.162	30% reduction	4.633	588.982	0.995	0.518	1.493
PSPRS_TOTAL	94	3.723	8.15	30% reduction	2.606	835.718	0.995	0.518	1.493
CBS_LCB_SCORE	94	2.616	6.27	30% reduction	1.831	1001.987	0.995	0.518	1.493
UPDRS_SCORE	94	3.789	9.275	30% reduction	2.652	1045.001	0.995	0.518	1.493
CBS_NONMOTOR_SCORE	94	0.745	2.62	30% reduction	0.522	2155.611	0.995	0.518	1.493

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New Spaghetti plots

Black line = LOESS, Red = Linear effect

Left plot is all data. Right is restricted to ~ 1.5 years

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