Part 7: In-Class Lab Activity

EPI 553 — Logistic Regression Part 1 Lab Due: April 13, 2026

Instructions

Complete the four tasks below using the BRFSS 2020 dataset (brfss_logistic_2020.rds). Submit a knitted HTML file via Brightspace. You may collaborate, but each student must submit their own work.

Data

Variable Description Type
fmd Frequent mental distress (No/Yes) Factor (outcome)
menthlth_days Mentally unhealthy days (0-30) Numeric
physhlth_days Physically unhealthy days (0-30) Numeric
sleep_hrs Hours of sleep per night Numeric
age Age in years Numeric
sex Male / Female Factor
bmi Body mass index Numeric
exercise Exercised in past 30 days (No/Yes) Factor
income_cat Household income category (1-8) Numeric
smoker Former/Never vs. Current Factor
library(tidyverse)
## Warning: package 'tidyverse' was built under R version 4.5.2
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library(broom)
## Warning: package 'broom' was built under R version 4.5.2
library(knitr)
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library(kableExtra)
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## 
## Attaching package: 'kableExtra'
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## 
##     group_rows
library(gtsummary)
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library(ggeffects)
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options(gtsummary.use_ftExtra = TRUE)
set_gtsummary_theme(theme_gtsummary_compact(set_theme = TRUE))
## Setting theme "Compact"
## Setting theme "Compact"
brfss_logistic <- readRDS("C:/Users/abbym/OneDrive/Desktop/STATS553/R Materials/epi553/scripts/brfss_logistic.rds")

Task 1: Explore the Binary Outcome (15 points)

brfss_logistic |>
  select(fmd) |>
  tbl_summary(
    type = list(fmd ~ "categorical"),
    label = list(
      fmd ~ "Frequent Mental Distress"
    ),
    statistic = list(
      all_categorical() ~ "{n} ({p}%)"
    )) |>
  add_n() |>
  bold_labels() |>
  modify_caption("**FMD Descriptive Statistics**")
FMD Descriptive Statistics
Characteristic N N = 5,0001
Frequent Mental Distress 5,000
    No
4,243 (85%)
    Yes
757 (15%)
1 n (%)
brfss_logistic |>
  tbl_summary(
    by = fmd,
    include = c(physhlth_days, sleep_hrs, age, sex, bmi, exercise,
                income_cat, smoker),
    type = list(
      c(physhlth_days, sleep_hrs, age, bmi, income_cat) ~ "continuous"
    ),
    statistic = list(
      all_continuous() ~ "{mean} ({sd})"
    ),
    label = list(
      physhlth_days ~ "Physical unhealthy days",
      sleep_hrs     ~ "Sleep hours",
      age           ~ "Age (years)",
      sex           ~ "Sex",
      bmi           ~ "BMI",
      exercise      ~ "Exercise in past 30 days",
      income_cat    ~ "Income category (1-8)",
      smoker        ~ "Smoking status"
    )
  ) |>
  add_overall() |>
  add_p() |>
  bold_labels()
Characteristic Overall
N = 5,000
1
No
N = 4,243
1
Yes
N = 757
1
p-value2
Physical unhealthy days 4 (9) 3 (8) 10 (13) <0.001
Sleep hours 7.00 (1.48) 7.09 (1.40) 6.51 (1.83) <0.001
Age (years) 56 (16) 57 (16) 50 (16) <0.001
Sex


<0.001
    Male 2,701 (54%) 2,378 (56%) 323 (43%)
    Female 2,299 (46%) 1,865 (44%) 434 (57%)
BMI 28.5 (6.3) 28.4 (6.2) 29.3 (7.0) 0.001
Exercise in past 30 days 3,673 (73%) 3,192 (75%) 481 (64%) <0.001
Income category (1-8) 5.85 (2.11) 6.00 (2.04) 5.05 (2.29) <0.001
Smoking status


<0.001
    Former/Never 3,280 (66%) 2,886 (68%) 394 (52%)
    Current 1,720 (34%) 1,357 (32%) 363 (48%)
1 Mean (SD); n (%)
2 Wilcoxon rank sum test; Pearson’s Chi-squared test
brfss_logistic |>
  ggplot(aes(x = fmd, fill= exercise)) +
  geom_bar(color= "black", position= "dodge") +
  geom_text(stat= "count", aes(label= ..count..), position= position_dodge(width=0.9))+
  labs(
    title = "Figure 1: FMD Distribution by Exercise Status",
    x = "FMD",
    y = "Count of each FMD Status (yes/no)",
    caption = "Source: BRFSS"
  ) +
  theme_minimal() +
  theme(axis.text.x = element_text(angle = 45, hjust = 1))
## Warning: The dot-dot notation (`..count..`) was deprecated in ggplot2 3.4.0.
## ℹ Please use `after_stat(count)` instead.
## This warning is displayed once per session.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.

1a. (5 pts) Create a frequency table showing the number and percentage of individuals with and without frequent mental distress.

1b. (5 pts) Create a descriptive summary table of at least 4 predictors, stratified by FMD status. Use tbl_summary().

1c. (5 pts) Create a bar chart showing the proportion of FMD by exercise status OR smoking status.

Task 2: Simple Logistic Regression (20 points)

# Fit a simple logistic model using exercise
mod_exercise <- glm(fmd ~ exercise, data = brfss_logistic,
                      family = binomial(link = "logit"))

# Report coefficients
tidy(mod_exercise, conf.int = TRUE, exponentiate = FALSE) |>
  kable(digits = 3, caption = "Simple Logistic Regression: FMD ~ Exercise (Log-Odds Scale)") |>
  kable_styling(bootstrap_options = "striped", full_width = FALSE)
Simple Logistic Regression: FMD ~ Exercise (Log-Odds Scale)
term estimate std.error statistic p.value conf.low conf.high
(Intercept) -1.337 0.068 -19.769 0 -1.471 -1.206
exerciseYes -0.555 0.083 -6.655 0 -0.718 -0.391
# Report coefficients
tidy(mod_exercise, conf.int = TRUE, exponentiate = TRUE) |>
  kable(digits = 3, caption = "Simple Logistic Regression: FMD ~ Exercise (Odds Ratio Scale)") |>
  kable_styling(bootstrap_options = "striped", full_width = FALSE)
Simple Logistic Regression: FMD ~ Exercise (Odds Ratio Scale)
term estimate std.error statistic p.value conf.low conf.high
(Intercept) 0.263 0.068 -19.769 0 0.230 0.299
exerciseYes 0.574 0.083 -6.655 0 0.488 0.676
mod_age <- glm(fmd ~ age, data = brfss_logistic,
               family = binomial(link = "logit"))


ggpredict(mod_age, terms = "age [18:80]") |>
  plot() +
  labs(title = "Predicted Probability of Frequent Mental Distress by Age",
       x = "Age (years)", y = "Predicted Probability of FMD") +
  theme_minimal()

2a. (5 pts) Fit a simple logistic regression model predicting FMD from exercise. Report the coefficients on the log-odds scale.

2b. (5 pts) Exponentiate the coefficients to obtain odds ratios with 95% confidence intervals.

2c. (5 pts) Interpret the odds ratio for exercise in the context of the research question. Compared to those who do not exercise, those who do have 42.6% decreased odds of having frequent mental distress. 2d. (5 pts) Create a plot showing the predicted probability of FMD across levels of a continuous predictor (e.g., age or sleep hours).

Task 3: Comparing Predictors (20 points)

# Smoking
mod_smoker <- glm(fmd ~ smoker, data = brfss_logistic,
               family = binomial(link = "logit"))
# Income-cat
mod_income <- glm(fmd ~ income_cat, data = brfss_logistic,
               family = binomial(link = "logit"))
#BMI
mod_bmi <- glm(fmd ~ bmi, data = brfss_logistic,
               family = binomial(link = "logit"))
tidy(mod_bmi, conf.int = TRUE, exponentiate = TRUE) |>
  kable(digits = 3, caption = "Simple Logistic Regression: FMD ~ BMI (Odds Ratio Scale)") |>
  kable_styling(bootstrap_options = "striped", full_width = FALSE)
Simple Logistic Regression: FMD ~ BMI (Odds Ratio Scale)
term estimate std.error statistic p.value conf.low conf.high
(Intercept) 0.094 0.178 -13.299 0 0.066 0.133
bmi 1.023 0.006 3.745 0 1.011 1.034
# Compare the fmd OR across models
tribble(
  ~Model, ~`Odds Ratio`, ~`95% CI`,
  "Smoker Model", round(exp(coef(mod_smoker))[2], 3),
    paste0("(", round(exp(confint(mod_smoker))[2,1],3), ", ", round(exp(confint(mod_smoker))[2,2],3), ")"),
  "Income Model",     round(exp(coef(mod_income))[2], 3),
    paste0("(", round(exp(confint(mod_income))[2,1],3), ", ", round(exp(confint(mod_income))[2,2],3), ")"),

  "BMI Model",       round(exp(coef(mod_bmi))[2], 3),
    paste0("(", round(exp(confint(mod_bmi))[2,1],3), ", ", round(exp(confint(mod_bmi))[2,2],3), ")")
) %>%
  kable(caption = "FMD OR Across Different Models") %>%
  kable_styling(bootstrap_options = c("striped", "hover"), full_width = FALSE) %>%
  row_spec(0, bold = TRUE)
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FMD OR Across Different Models
Model Odds Ratio 95% CI
Smoker Model 1.959 (1.675, 2.291)
Income Model 0.821 (0.793, 0.85)
BMI Model 1.023 (1.011, 1.034)

3a. (5 pts) Fit three separate simple logistic regression models, each with a different predictor of your choice.

3b. (10 pts) Create a table comparing the odds ratios from all three models.

3c. (5 pts) Which predictor has the strongest crude association with FMD? Justify your answer. Smoking has the strongest crude association with FMD, because it has the largest odds ratio. The odds ratio of 1.959 means that those who smoke have almost 2 times the odds of having frequent mental distress than those who do not smoke. ## Task 4: Introduction to Multiple Logistic Regression (20 points)

mod_full <- glm(fmd ~ smoker + bmi + income_cat, data = brfss_logistic,
               family = binomial(link = "logit"))
# Create Table
mod_full |>
  tbl_regression(
    exponentiate = TRUE,
    label = list(
      bmi   ~ "BMI",
      smoker     ~ "Smoking status",
      income_cat ~ "Income category (per unit)"
    )
  ) |>
  bold_labels() |>
  bold_p()
Characteristic OR 95% CI p-value
Smoking status


    Former/Never
    Current 1.69 1.44, 1.99 <0.001
BMI 1.02 1.01, 1.03 <0.001
Income category (per unit) 0.84 0.81, 0.88 <0.001
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
# Crude ORs from simple models

crude_smoker <- tidy(mod_smoker, exponentiate = TRUE, conf.int = TRUE) |>
  filter(term == "smokerCurrent") |>
  dplyr::select(term, estimate, conf.low, conf.high) |>
  mutate(type = "Crude")

# Adjusted ORs from multiple model

adj_smoker <- tidy(mod_full, exponentiate = TRUE, conf.int = TRUE) |>
  filter(term == "smokerCurrent") |>
  dplyr::select(term, estimate, conf.low, conf.high) |>
  mutate(type = "Adjusted")

bind_rows(crude_smoker, adj_smoker) |>
  mutate(across(c(estimate, conf.low, conf.high), \(x) round(x, 3))) |>
  kable(col.names = c("Predictor", "OR", "95% CI Lower", "95% CI Upper", "Type"),
        caption = "Crude vs. Adjusted Odds Ratios") |>
  kable_styling(bootstrap_options = "striped", full_width = FALSE)
Crude vs. Adjusted Odds Ratios
Predictor OR 95% CI Lower 95% CI Upper Type
smokerCurrent 1.959 1.675 2.291 Crude
smokerCurrent 1.689 1.436 1.987 Adjusted

4a. (5 pts) Fit a multiple logistic regression model predicting FMD from at least 3 predictors.

4b. (5 pts) Report the adjusted odds ratios using tbl_regression().

4c. (5 pts) For one predictor, compare the crude OR (from Task 3) with the adjusted OR (from Task 4). Show both values.

4d. (5 pts) In 2-3 sentences, assess whether confounding is present for the predictor you chose. Which direction did the OR change, and what does this mean? Confounding is present for smoking. The OR decreased, meaning confounding inflates the relationship smoking has on frequent mental distress. Completion credit (25 points): Awarded for a complete, good-faith attempt at all tasks. Total: 75 + 25 = 100 points.

End of Lab Activity