#Creador: Paulina Aguilar #Grafica de Volcano

library(pacman)

p_load("readr",
       "ggplot2",
       "ggrepel",
       "matrixTests", #para realizar la prueba estadistica
       "dplyr")
datos <- read.csv("https://raw.githubusercontent.com/ManuelLaraMVZ/Transcript-mica/refs/heads/main/datos_miRNAs.csv")
head(datos)
##                  Gen Condicion     Cx1     Cx2     Cx3      T1      T2      T3
## 1    U6 snRNA-001973   Control 13.7904 11.7446 11.9293 13.1954 12.9566 12.6417
## 2 ath-miR159a-000338    Target 35.0000 35.0000 35.0000 35.0000 35.0000 35.0000
## 3  hsa-let-7a-000377    Target 20.4943 21.0031 21.0073 20.3820 19.5925 20.9335
## 4  hsa-let-7b-002619    Target 18.3545 19.0325 19.1368 18.2551 17.4500 18.9675
## 5  hsa-let-7c-000379    Target 22.1791 23.6921 23.7763 22.9127 21.9639 23.9877
## 6  hsa-let-7d-002283    Target 22.1898 22.6786 21.8660 21.9711 21.2081 21.9410

#extracción de genes controles (referencia)

Controles <- datos %>% 
  filter(Condicion=="Control")
head(Controles)
##               Gen Condicion     Cx1     Cx2     Cx3      T1      T2      T3
## 1 U6 snRNA-001973   Control 13.7904 11.7446 11.9293 13.1954 12.9566 12.6417
## 2    RNU44-001094   Control 17.2530 16.8649 16.8359 17.6667 17.3156 16.7527
## 3    RNU48-001006   Control 15.1057 16.4211 16.9914 16.0151 15.0702 16.4404
promedio_controles <- Controles %>% 
  summarise(Mean_C1=mean(Cx1),
            Mean_C2=mean(Cx2),
            Mean_C3=mean(Cx3),
            Mean_T1=mean(T1),
            Mean_T2=mean(T2),
            Mean_T3=mean(T3)) %>% 
  mutate(Gen="Promedio_controles") %>% 
  select(7,1,2,3,4,5,6)
promedio_controles
##                  Gen  Mean_C1 Mean_C2 Mean_C3  Mean_T1  Mean_T2  Mean_T3
## 1 Promedio_controles 15.38303 15.0102 15.2522 15.62573 15.11413 15.27827

#Extraer los genes de la tabla “datos”

genes<- datos %>% 
  filter(Condicion=="Target") %>% 
  select(-2)
head(genes)
##                  Gen     Cx1     Cx2     Cx3      T1      T2      T3
## 1 ath-miR159a-000338 35.0000 35.0000 35.0000 35.0000 35.0000 35.0000
## 2  hsa-let-7a-000377 20.4943 21.0031 21.0073 20.3820 19.5925 20.9335
## 3  hsa-let-7b-002619 18.3545 19.0325 19.1368 18.2551 17.4500 18.9675
## 4  hsa-let-7c-000379 22.1791 23.6921 23.7763 22.9127 21.9639 23.9877
## 5  hsa-let-7d-002283 22.1898 22.6786 21.8660 21.9711 21.2081 21.9410
## 6  hsa-let-7e-002406 17.9679 18.3915 18.4673 18.0119 17.2932 18.5586

#Sacar el 2^-DCT

DCT <- genes %>%
  mutate(DCT_C1=2^(Cx1- promedio_controles$Mean_C1),
         DCT_C2=2^(Cx2- promedio_controles$Mean_C2),
         DCT_C3=2^(Cx3- promedio_controles$Mean_C3),
         DCT_T1=2^(T1- promedio_controles$Mean_T1),
         DCT_T2=2^(T2- promedio_controles$Mean_T2),
         DCT_T3=2^(T3- promedio_controles$Mean_T3)) %>%
  select(-2,-3,-4,-5,-6,-7)

DCT
##                         Gen       DCT_C1       DCT_C2       DCT_C3       DCT_T1
## 1        ath-miR159a-000338 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 2         hsa-let-7a-000377 3.456564e+01 6.368581e+01 5.400795e+01 2.702582e+01
## 3         hsa-let-7b-002619 7.843332e+00 1.624924e+01 1.477002e+01 6.187543e+00
## 4         hsa-let-7c-000379 1.111271e+02 4.106883e+02 3.681373e+02 1.561693e+02
## 5         hsa-let-7d-002283 1.119543e+02 2.034316e+02 9.793822e+01 8.131033e+01
## 6         hsa-let-7e-002406 5.999601e+00 1.042012e+01 9.286275e+00 5.227665e+00
## 7         hsa-let-7f-000382 5.250339e+02 1.133525e+03 6.844494e+02 2.796477e+02
## 8         hsa-let-7g-002282 1.038003e+02 1.388227e+02 1.518602e+02 1.014248e+02
## 9          hsa-miR-1-002222 6.649539e+04 2.472995e+05 1.512735e+05 1.668355e+05
## 10       hsa-miR-100-000437 3.485019e+00 2.565962e+00 2.007778e+00 2.438623e+00
## 11       hsa-miR-101-002253 1.068476e+04 4.476861e+04 4.187495e+04 1.038538e+04
## 12       hsa-miR-103-000439 2.118893e+02 1.333960e+03 1.179288e+03 1.997798e+02
## 13       hsa-miR-105-002167 8.040728e+05 1.152916e+04 1.064361e+04 6.795719e+05
## 14      hsa-miR-106a-002169 5.918529e+01 1.365540e+01 1.180642e+01 4.036594e+01
## 15      hsa-miR-106b-000442 3.846938e+02 3.892626e+02 3.590398e+02 2.859000e+02
## 16       hsa-miR-107-000443 5.337937e+03 2.109188e+04 2.813347e+04 4.925200e+03
## 17       hsa-miR-10a-000387 5.774558e+02 2.832437e+02 2.629783e+02 1.537845e+02
## 18       hsa-miR-10b-002218 8.040728e+05 1.269309e+02 1.381316e+02 6.795719e+05
## 19       hsa-miR-122-002245 8.040728e+05 8.168186e+03 1.136728e+04 6.795719e+05
## 20   hsa-miR-125a-3p-002199 1.047140e+04 5.766179e+03 5.762583e+03 1.236407e+04
## 21   hsa-miR-125a-5p-002198 1.696911e+02 5.132180e+01 5.167878e+01 1.637631e+02
## 22      hsa-miR-125b-000449 4.788144e+00 3.935918e+00 3.600008e+00 5.041897e+00
## 23       hsa-miR-126-002228 1.516568e+02 2.387644e+04 1.946777e+04 1.638767e+02
## 24       hsa-miR-127-000452 2.408673e+01 7.766388e+02 8.257149e+02 1.872335e+01
## 25    hsa-miR-127-5p-002229 2.558904e+05 1.041189e+06 8.804002e+05 1.256862e+05
## 26      hsa-miR-128a-002216 2.359993e+03 7.914596e+03 6.730043e+03 2.333964e+03
## 27       hsa-miR-129-000590 8.040728e+05 7.529300e+03 7.853391e+03 6.795719e+05
## 28      hsa-miR-130a-000454 4.990244e+02 2.937351e+03 1.391669e+03 2.486317e+02
## 29      hsa-miR-130b-000456 8.765950e+02 8.142342e+02 8.452885e+02 6.526957e+02
## 30       hsa-miR-132-000457 2.728694e+02 4.729028e+02 2.705029e+02 1.423863e+02
## 31      hsa-miR-133a-002246 8.556272e+03 1.344703e+04 1.191507e+04 1.038178e+04
## 32      hsa-miR-133b-002247 2.107198e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 33      hsa-miR-135a-000460 5.461231e+05 1.041189e+06 3.980251e+05 8.242913e+04
## 34      hsa-miR-135b-002261 1.987775e+04 6.815010e+03 6.136073e+03 4.079110e+04
## 35       hsa-miR-136-000592 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 36       hsa-miR-138-002284 8.764298e+01 4.465965e+01 4.036128e+01 6.677641e+01
## 37    hsa-miR-139-3p-002313 8.040728e+05 1.110659e+03 3.102682e+03 6.795719e+05
## 38    hsa-miR-139-5p-002289 2.420965e+03 8.908878e+02 8.337667e+02 2.001362e+03
## 39    hsa-miR-140-3p-002234 1.005270e+03 3.950994e+03 6.236842e+03 2.607708e+03
## 40       hsa-miR-141-000463 8.040728e+05 4.912167e+05 1.318465e+05 3.316189e+05
## 41    hsa-miR-142-3p-000464 4.789338e+05 1.088740e+05 9.808195e+04 6.748778e+05
## 42    hsa-miR-142-5p-002248 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 43       hsa-miR-143-002249 4.054822e+01 7.993990e+03 8.965075e+03 3.845413e+01
## 44       hsa-miR-145-002278 2.966099e+00 1.182890e+03 1.355773e+03 3.200876e+00
## 45      hsa-miR-146a-000468 1.717891e+01 2.518463e+02 2.912068e+02 2.066714e+01
## 46      hsa-miR-146b-001097 4.519648e+02 3.435080e+02 3.607361e+02 5.241975e+02
## 47   hsa-miR-146b-3p-002361 3.345807e+04 1.041189e+06 5.834300e+05 1.242053e+05
## 48       hsa-miR-147-000469 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 49      hsa-miR-147b-002262 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 50      hsa-miR-148a-000470 1.357099e+05 1.041189e+06 4.546510e+05 3.707006e+04
## 51      hsa-miR-148b-000471 6.340561e+02 3.803205e+03 3.526203e+03 5.225288e+02
## 52       hsa-miR-149-002255 9.650064e+01 5.901754e+02 7.223729e+02 9.271730e+01
## 53       hsa-miR-150-000473 6.769523e+04 2.510348e+04 2.390956e+04 3.991011e+04
## 54       hsa-miR-152-000475 9.377729e+01 5.317116e+02 3.851029e+02 8.094481e+01
## 55       hsa-miR-154-000477 2.794430e+04 1.041189e+06 8.804002e+05 1.375403e+04
## 56       hsa-miR-155-002623 8.736833e+02 8.104774e+01 7.709151e+01 1.113717e+03
## 57       hsa-miR-15a-000389 1.579187e+03 1.041189e+06 8.804002e+05 1.420878e+03
## 58       hsa-miR-15b-000390 1.304241e+02 4.914252e+01 5.052761e+01 1.205649e+02
## 59        hsa-miR-16-000391 4.049205e+01 2.457807e+01 1.849547e+01 3.766276e+01
## 60        hsa-miR-17-002308 5.476061e+01 1.327831e+01 1.025389e+01 3.735596e+01
## 61      hsa-miR-181a-000480 1.053077e+02 2.305922e+02 2.211528e+02 1.096808e+02
## 62      hsa-miR-181c-000482 2.878630e+03 2.226670e+04 1.289389e+04 1.791518e+03
## 63       hsa-miR-182-002334 2.591929e+05 3.149205e+04 4.324663e+04 6.795719e+05
## 64       hsa-miR-183-002269 8.040728e+05 4.132136e+04 7.501544e+04 6.795719e+05
## 65       hsa-miR-184-000485 7.466760e+03 1.175185e+04 8.799464e+03 5.186576e+03
## 66       hsa-miR-185-002271 2.222344e+03 4.219335e+03 4.844728e+03 2.121791e+03
## 67       hsa-miR-186-002285 1.441911e+03 2.000022e+03 5.852868e+02 3.329511e+02
## 68    hsa-miR-188-3p-002106 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 69       hsa-miR-18a-002422 2.303109e+03 2.538745e+03 2.551624e+03 2.439664e+03
## 70       hsa-miR-18b-002217 1.090494e+03 2.845961e+03 2.238785e+03 1.423441e+03
## 71       hsa-miR-190-000489 1.376044e+05 1.041189e+06 4.452944e+05 2.565170e+04
## 72       hsa-miR-191-002299 2.328238e+01 5.864874e+00 5.550816e+00 2.055998e+01
## 73       hsa-miR-192-000491 7.460035e+03 3.681811e+03 2.749207e+03 2.643561e+03
## 74   hsa-miR-193a-3p-002250 1.240332e+05 6.529441e+05 4.092435e+05 1.696459e+05
## 75   hsa-miR-193a-5p-002281 1.457717e+02 5.571029e+02 5.464327e+02 1.619570e+02
## 76      hsa-miR-193b-002367 1.405651e+01 4.050421e+01 5.134315e+01 1.437776e+01
## 77       hsa-miR-194-000493 5.972696e+03 3.882580e+03 3.096451e+03 4.904080e+03
## 78       hsa-miR-195-000494 1.116345e+03 4.435337e+02 2.532643e+02 4.610140e+02
## 79      hsa-miR-196b-002215 2.547754e+05 7.737072e+04 1.058015e+05 1.721214e+05
## 80       hsa-miR-197-000497 9.200030e+01 1.297059e+02 9.920219e+01 8.513419e+01
## 81       hsa-miR-198-002273 8.754072e+04 1.041189e+06 8.804002e+05 8.206427e+04
## 82      hsa-miR-199a-000498 5.960703e+03 1.041189e+06 8.804002e+05 4.793510e+03
## 83   hsa-miR-199a-3p-002304 1.892035e+01 6.933518e+04 8.006033e+04 2.041230e+01
## 84      hsa-miR-199b-000500 5.245769e+04 2.358157e+05 8.804002e+05 1.759608e+04
## 85       hsa-miR-19a-000395 3.045144e+02 4.314352e+02 3.458733e+02 3.007178e+02
## 86       hsa-miR-19b-000396 1.233398e+01 5.758528e+00 4.918778e+00 1.039968e+01
## 87      hsa-miR-200a-000502 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 88      hsa-miR-200b-002251 1.075013e+04 7.052896e+03 3.865395e+03 1.092667e+04
## 89      hsa-miR-200c-002300 1.849048e+03 3.752739e+02 4.220880e+02 2.052216e+03
## 90       hsa-miR-202-002363 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 91       hsa-miR-203-000507 5.925571e+04 2.436752e+05 1.623446e+05 4.263547e+04
## 92       hsa-miR-204-000508 4.110695e+03 5.103347e+02 3.978277e+02 2.052927e+03
## 93       hsa-miR-205-000509 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 94       hsa-miR-208-000511 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 95      hsa-miR-208b-002290 8.040728e+05 1.041189e+06 8.804002e+05 7.972622e+04
## 96       hsa-miR-20a-000580 1.112350e+02 2.142762e+01 2.128109e+01 7.809545e+01
## 97       hsa-miR-20b-001014 9.114797e+02 3.466894e+02 2.073178e+02 6.427290e+02
## 98        hsa-miR-21-000397 6.382257e+00 1.003870e+01 8.333947e+00 5.788809e+00
## 99       hsa-miR-210-000512 3.465132e+02 3.787043e+01 3.389969e+01 3.140753e+02
## 100      hsa-miR-211-000514 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 101      hsa-miR-212-000515 2.830158e+03 5.361794e+03 2.803280e+03 1.748942e+03
## 102      hsa-miR-214-002306 3.847013e+01 1.041189e+06 8.804002e+05 4.078217e+01
## 103      hsa-miR-215-000518 8.040728e+05 2.882890e+03 1.437554e+03 6.795719e+05
## 104     hsa-miR-216a-002220 8.040728e+05 1.041189e+06 8.804002e+05 6.743166e+05
## 105     hsa-miR-216b-002326 8.040728e+05 1.041189e+06 2.555773e+05 6.795719e+05
## 106      hsa-miR-217-002337 4.201563e+05 1.041189e+06 8.804002e+05 1.828456e+05
## 107      hsa-miR-218-000521 2.936119e+02 4.152108e+02 3.525050e+02 2.739686e+02
## 108      hsa-miR-219-000522 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 109 hsa-miR-219-1-3p-002095 3.078924e+05 2.481065e+05 8.781014e+04 4.152632e+05
## 110 hsa-miR-219-2-3p-002390 5.531101e+00 1.041189e+06 8.804002e+05 6.795719e+05
## 111       hsa-miR-22-000398 6.606282e+01 1.827592e+02 1.913938e+02 8.078786e+01
## 112      hsa-miR-220-000523 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 113     hsa-miR-220b-002206 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 114     hsa-miR-220c-002211 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 115      hsa-miR-221-000524 1.642665e+01 2.453042e+01 2.554201e+01 1.545891e+01
## 116      hsa-miR-222-002276 4.425274e+00 2.142210e+00 1.575708e+00 2.509268e+00
## 117      hsa-miR-223-002295 1.112229e+04 1.201043e+04 8.428148e+03 1.034587e+04
## 118      hsa-miR-224-002099 5.813111e+02 3.784796e+03 6.881465e+03 6.663178e+02
## 119      hsa-miR-23a-000399 6.636114e+01 1.355518e+02 2.075334e+02 7.209197e+01
## 120      hsa-miR-23b-000400 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 121       hsa-miR-24-000402 7.578933e-01 8.033340e+00 5.896259e+00 5.719126e-01
## 122       hsa-miR-25-000403 1.652995e+03 3.682138e+02 3.155227e+02 9.009896e+02
## 123      hsa-miR-26a-000405 5.175645e+01 6.046381e+01 4.028861e+01 3.971375e+01
## 124      hsa-miR-26b-000407 1.150118e+03 2.054398e+03 5.390592e+02 1.918542e+02
## 125      hsa-miR-27a-000408 4.165641e+01 2.326149e+02 2.108247e+02 3.713137e+01
## 126      hsa-miR-27b-000409 1.581080e+02 1.005153e+03 7.703659e+02 1.628914e+02
## 127       hsa-miR-28-000411 3.789508e+02 7.127736e+02 6.824124e+02 3.247007e+02
## 128    hsa-miR-28-3p-002446 3.756295e+02 2.434025e+02 2.073609e+02 2.607397e+02
## 129      hsa-miR-296-000527 1.113871e+03 2.231237e+02 1.248455e+02 6.467510e+02
## 130   hsa-miR-296-3p-002101 1.158314e+05 3.138309e+04 2.871068e+04 9.299507e+04
## 131      hsa-miR-298-002190 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 132   hsa-miR-299-3p-001015 8.040728e+05 1.041189e+06 8.804002e+05 4.277969e+05
## 133   hsa-miR-299-5p-000600 5.584323e+03 4.300366e+05 3.363258e+05 4.289419e+03
## 134      hsa-miR-29a-002112 5.324945e+00 1.378787e+00 1.358580e+00 4.933347e+00
## 135      hsa-miR-29b-000413 3.734156e+03 5.135539e+03 5.314064e+03 3.117917e+03
## 136      hsa-miR-29c-000587 8.774290e+03 1.715365e+03 2.122617e+02 5.368468e+02
## 137      hsa-miR-301-000528 1.467115e+03 2.870869e+04 3.108864e+04 1.426206e+03
## 138     hsa-miR-301b-002392 6.370711e+04 5.410866e+05 4.519489e+05 4.452619e+04
## 139     hsa-miR-302a-000529 2.476637e+03 6.801663e+04 4.928975e+04 1.929307e+03
## 140     hsa-miR-302b-000531 2.145156e+03 1.041189e+06 1.509070e+05 3.921513e+02
## 141     hsa-miR-302c-000533 2.712717e+01 1.187372e+01 4.753203e+00 2.395021e+01
## 142      hsa-miR-30b-000602 2.336969e+01 2.751221e+01 2.647392e+01 2.018297e+01
## 143      hsa-miR-30c-000419 1.509048e+01 2.198427e+01 2.183544e+01 1.496652e+01
## 144       hsa-miR-31-002279 5.972217e+00 1.041189e+06 8.804002e+05 5.086124e+00
## 145       hsa-miR-32-002109 1.345485e+05 1.322034e+05 2.309146e+05 1.863386e+05
## 146      hsa-miR-320-002277 5.006279e+01 4.936443e+01 5.008477e+01 4.043595e+01
## 147   hsa-miR-323-3p-002227 5.712057e+02 5.150411e+04 2.271094e+04 6.629088e+02
## 148   hsa-miR-324-3p-002161 5.295660e+02 1.013198e+03 1.086370e+03 5.144427e+02
## 149   hsa-miR-324-5p-000539 1.399375e+03 6.806512e+03 6.120357e+03 1.074364e+03
## 150      hsa-miR-325-000540 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 151      hsa-miR-326-000542 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 152      hsa-miR-328-000543 3.011350e+02 1.407091e+03 1.065267e+03 2.129937e+02
## 153      hsa-miR-329-001101 1.718744e+04 9.519512e+04 1.778005e+05 9.988599e+03
## 154      hsa-miR-330-000544 2.492654e+03 1.715094e+04 2.353467e+04 1.936676e+03
## 155   hsa-miR-330-5p-002230 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 156      hsa-miR-331-000545 2.857470e+01 3.193733e+02 3.112219e+02 2.725533e+01
## 157   hsa-miR-331-5p-002233 9.780134e+04 6.521427e+04 2.126469e+05 7.142625e+04
## 158      hsa-miR-335-000546 4.654127e+02 6.856365e+02 6.402538e+02 3.391469e+02
## 159   hsa-miR-337-5p-002156 1.906177e+03 2.303711e+05 2.186858e+05 2.153200e+03
## 160   hsa-miR-338-3p-002252 8.040728e+05 2.104474e+05 8.804002e+05 6.795719e+05
## 161   hsa-miR-339-3p-002184 9.956305e+02 9.305243e+02 8.428313e+02 1.010439e+03
## 162   hsa-miR-339-5p-002257 2.365115e+02 4.235534e+02 3.636735e+02 1.853190e+02
## 163      hsa-miR-33b-002085 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 164      hsa-miR-340-002258 1.087906e+04 9.163886e+05 8.364385e+05 1.048084e+04
## 165   hsa-miR-342-3p-002260 1.572010e+02 5.243186e+02 7.642496e+02 2.387351e+02
## 166   hsa-miR-342-5p-002147 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 167      hsa-miR-345-002186 5.303742e+02 3.487381e+02 3.557451e+02 5.243792e+02
## 168      hsa-miR-346-000553 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 169      hsa-miR-34a-000426 1.146400e+02 9.014028e+01 8.210510e+01 1.123508e+02
## 170      hsa-miR-34c-000428 5.781254e+03 2.747820e+04 1.287960e+04 4.946412e+03
## 171      hsa-miR-361-000554 2.640447e+03 3.556395e+03 3.063574e+03 1.834621e+03
## 172      hsa-miR-362-001273 2.518356e+03 3.179976e+03 2.731353e+03 2.577696e+03
## 173   hsa-miR-362-3p-002117 2.074199e+04 4.130131e+04 3.920908e+04 1.913686e+04
## 174      hsa-miR-363-001271 2.833832e+04 1.041189e+06 8.804002e+05 2.079237e+04
## 175      hsa-miR-365-001020 5.607814e+01 3.777008e+02 4.259381e+02 8.222850e+01
## 176      hsa-miR-367-000555 5.974585e+01 1.332600e+02 1.058076e+02 3.176721e+01
## 177   hsa-miR-369-3p-000557 1.572136e+05 1.041189e+06 8.804002e+05 2.441985e+04
## 178   hsa-miR-369-5p-001021 2.669102e+04 1.095249e+05 2.405705e+05 4.529822e+04
## 179      hsa-miR-370-002275 8.861424e+01 6.634629e+03 8.582011e+03 8.254258e+01
## 180   hsa-miR-371-3p-002124 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 181      hsa-miR-372-000560 4.920327e+04 5.737362e+04 5.577767e+04 9.976642e+04
## 182      hsa-miR-373-000561 3.338329e+05 1.041189e+06 8.804002e+05 9.449607e+04
## 183      hsa-miR-374-000563 1.316776e+02 4.903269e+02 3.128875e+02 6.308996e+02
## 184      hsa-miR-375-000564 3.951023e+05 5.839673e+04 2.663619e+04 1.231764e+05
## 185     hsa-miR-376a-000565 7.530463e+01 1.485363e+03 1.218086e+03 5.384971e+01
## 186     hsa-miR-376b-001102 5.806378e+01 3.410237e+01 3.295213e+01 8.015756e+01
## 187     hsa-miR-376c-002122 3.865188e+01 9.679576e+02 7.017435e+02 3.832109e+01
## 188      hsa-miR-377-000566 1.476984e+04 1.041189e+06 8.804002e+05 6.795719e+05
## 189   hsa-miR-380-3p-000569 1.275669e+04 1.041189e+06 8.804002e+05 9.368918e+03
## 190      hsa-miR-381-000571 5.777936e+04 9.824333e+05 3.917571e+05 2.043092e+04
## 191      hsa-miR-382-000572 5.389078e+01 2.034982e+03 1.246442e+03 5.865843e+01
## 192      hsa-miR-383-000573 2.772244e+04 1.041189e+06 8.804002e+05 1.977879e+04
## 193      hsa-miR-384-000574 8.040728e+05 2.889435e+04 8.804002e+05 6.795719e+05
## 194   hsa-miR-409-5p-002331 3.564704e+03 5.278352e+04 8.705865e+04 4.919059e+03
## 195      hsa-miR-410-001274 1.636578e+03 9.234204e+04 1.069517e+05 9.330863e+02
## 196      hsa-miR-411-001610 1.098253e+02 3.327447e+03 2.341959e+03 8.129905e+01
## 197      hsa-miR-412-001023 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 198     hsa-miR-422a-002297 1.707581e+04 1.092238e+04 1.304763e+04 1.512625e+04
## 199   hsa-miR-423-5p-002340 4.803488e+03 5.672622e+03 5.843431e+03 5.235700e+03
## 200      hsa-miR-424-000604 6.120945e+04 2.827031e+04 2.628587e+04 3.537559e+04
## 201   hsa-miR-425-5p-001516 1.313014e+03 3.957924e+02 3.739237e+02 1.141857e+03
## 202      hsa-miR-429-001024 2.010600e+05 1.041189e+06 8.804002e+05 1.513644e+05
## 203      hsa-miR-431-001979 1.778684e+02 4.954268e+01 5.465191e+01 1.601929e+02
## 204      hsa-miR-433-001028 1.531327e+03 5.836145e+03 1.394732e+04 1.313196e+03
## 205      hsa-miR-448-001029 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 206      hsa-miR-449-001030 4.584379e+05 7.335095e+03 1.029888e+04 6.521601e+05
## 207     hsa-miR-449b-001608 3.920741e+05 4.751278e+03 5.132336e+03 4.450151e+04
## 208     hsa-miR-450a-002303 2.762078e+04 3.569415e+04 5.503264e+04 4.168575e+04
## 209  hsa-miR-450b-3p-002208 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 210  hsa-miR-450b-5p-002207 1.824982e+03 1.041189e+06 8.804002e+05 6.795719e+05
## 211      hsa-miR-452-002329 1.654256e+03 1.041189e+06 8.804002e+05 1.323339e+03
## 212      hsa-miR-453-002318 2.572420e+05 1.041189e+06 8.804002e+05 1.138967e+05
## 213      hsa-miR-454-002323 4.296943e+02 8.154768e+02 6.043330e+02 2.708719e+02
## 214      hsa-miR-455-001280 1.367066e+03 2.910598e+03 3.213434e+03 1.315747e+03
## 215   hsa-miR-455-3p-002244 8.336897e+02 5.133859e+02 5.540990e+02 6.521078e+02
## 216   hsa-miR-483-5p-002338 9.209062e+04 1.101798e+05 5.220861e+04 4.124886e+04
## 217      hsa-miR-484-001821 3.580941e+01 4.267739e+01 4.194422e+01 3.208810e+01
## 218   hsa-miR-485-3p-001277 5.949673e+02 2.233007e+04 1.895643e+04 5.565111e+02
## 219   hsa-miR-485-5p-001036 7.584271e+02 1.041189e+06 8.804002e+05 4.189885e+02
## 220      hsa-miR-486-001278 7.978063e+01 3.100102e+03 1.869323e+03 7.943851e+01
## 221   hsa-miR-486-3p-002093 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 222     hsa-miR-487a-001279 3.656548e+03 6.106254e+04 8.804002e+05 2.707915e+03
## 223     hsa-miR-487b-001285 3.770643e+02 1.653689e+04 2.281192e+04 3.280261e+02
## 224      hsa-miR-488-002357 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 225      hsa-miR-489-002358 1.703562e+04 1.587754e+04 1.363474e+04 1.023885e+04
## 226      hsa-miR-490-001037 7.489941e+04 1.041189e+06 8.804002e+05 1.410449e+04
## 227   hsa-miR-491-3p-002360 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 228      hsa-miR-492-001039 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 229      hsa-miR-493-002364 1.193156e+03 9.708764e+04 1.549024e+05 1.120842e+03
## 230      hsa-miR-494-002365 1.486697e+02 3.301944e+03 3.444312e+03 1.537845e+02
## 231   hsa-miR-499-3p-002427 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 232      hsa-miR-500-002428 6.047263e+03 6.495388e+03 6.755281e+03 5.276138e+03
## 233      hsa-miR-501-001047 2.440171e+03 1.079165e+03 2.270352e+03 1.994023e+03
## 234   hsa-miR-501-3p-002435 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 235      hsa-miR-502-001109 4.912489e+04 8.440261e+04 2.619130e+04 1.162438e+04
## 236   hsa-miR-502-3p-002083 1.199434e+04 1.061341e+04 1.348156e+04 2.035741e+04
## 237      hsa-miR-503-001048 2.491051e+04 3.062241e+04 2.712809e+04 1.983508e+04
## 238      hsa-miR-504-002084 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 239      hsa-miR-505-002089 3.998565e+03 1.041189e+06 7.349855e+03 3.202686e+03
## 240      hsa-miR-506-001050 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 241      hsa-miR-507-001051 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 242      hsa-miR-508-001052 3.013889e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 243   hsa-miR-508-5p-002092 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 244 hsa-miR-509-3-5p-002155 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 245   hsa-miR-509-5p-002235 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 246      hsa-miR-510-002241 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 247      hsa-miR-511-001111 9.212613e+02 1.041189e+06 8.804002e+05 4.439233e+02
## 248   hsa-miR-512-3p-001823 2.314541e+05 4.050825e+03 3.273005e+03 1.519531e+05
## 249   hsa-miR-512-5p-001145 8.040728e+05 1.007257e+06 8.804002e+05 6.795719e+05
## 250   hsa-miR-513-5p-002090 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 251   hsa-miR-515-3p-002369 1.012332e+03 8.525260e+02 6.280780e+02 1.250480e+03
## 252   hsa-miR-515-5p-001112 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 253  hsa-miR-516a-5p-002416 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 254     hsa-miR-516b-001150 8.040728e+05 8.482489e+04 2.156302e+05 6.795719e+05
## 255     hsa-miR-517a-002402 5.036865e+05 7.456588e+03 6.283271e+03 5.077880e+05
## 256     hsa-miR-517b-001152 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 257     hsa-miR-517c-001153 1.235698e+05 9.556721e+03 6.935576e+03 3.884030e+04
## 258  hsa-miR-518a-3p-002397 8.040728e+05 5.619289e+04 9.158349e+04 1.420133e+05
## 259  hsa-miR-518a-5p-002396 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 260     hsa-miR-518b-001156 8.040728e+05 1.660811e+04 1.157801e+04 6.795719e+05
## 261     hsa-miR-518c-002401 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 262     hsa-miR-518d-001159 8.040728e+05 9.864101e+04 8.804002e+05 6.795719e+05
## 263  hsa-miR-518d-5p-002389 7.831381e+00 1.041189e+06 1.454045e+01 6.795719e+05
## 264     hsa-miR-518e-002395 8.040728e+05 3.110157e+04 4.178218e+04 6.795719e+05
## 265     hsa-miR-518f-002388 8.040728e+05 4.540615e+04 2.615139e+04 6.795719e+05
## 266     hsa-miR-519a-002415 2.573847e+05 1.203126e+04 1.351899e+04 1.698694e+05
## 267     hsa-miR-519c-001163 8.040728e+05 5.033143e+05 2.354890e+05 6.795719e+05
## 268     hsa-miR-519d-002403 8.040728e+05 2.242313e+04 2.141153e+04 6.795719e+05
## 269     hsa-miR-519e-002370 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 270    hsa-miR-520a#-001168 8.040728e+05 9.504348e+04 8.804002e+05 6.795719e+05
## 271     hsa-miR-520a-001167 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 272     hsa-miR-520b-001116 8.040728e+05 2.447586e+05 1.883035e+05 5.815593e+05
## 273  hsa-miR-520d-5p-002393 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 274     hsa-miR-520e-001119 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 275     hsa-miR-520f-001120 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 276     hsa-miR-520g-001121 8.040728e+05 1.814897e+04 1.065542e+04 6.795719e+05
## 277      hsa-miR-521-001122 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 278      hsa-miR-522-002413 8.040728e+05 4.856401e+04 5.838864e+04 9.291775e+04
## 279      hsa-miR-523-002386 2.569847e+03 9.127474e+03 6.900705e+02 1.266180e+03
## 280   hsa-miR-524-5p-001982 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 281      hsa-miR-525-001174 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 282   hsa-miR-525-3p-002385 8.040728e+05 9.093827e+04 2.103016e+05 6.795719e+05
## 283     hsa-miR-526b-002382 8.040728e+05 1.041189e+06 5.692600e+04 6.795719e+05
## 284      hsa-miR-532-001518 3.112363e+02 3.610363e+02 4.180118e+02 3.273674e+02
## 285   hsa-miR-532-3p-002355 2.201035e+03 2.647656e+03 3.406324e+03 2.559359e+03
## 286      hsa-miR-539-001286 1.414616e+02 5.317381e+03 6.658585e+03 1.386753e+02
## 287      hsa-miR-541-002201 2.023783e+04 1.041189e+06 8.804002e+05 1.970353e+04
## 288   hsa-miR-542-3p-001284 2.577775e+05 2.633460e+05 1.089495e+05 9.776068e+04
## 289   hsa-miR-542-5p-002240 2.014087e+05 1.041189e+06 2.252238e+05 2.686683e+05
## 290      hsa-miR-544-002265 3.879380e+05 1.041189e+06 8.804002e+05 6.623190e+05
## 291      hsa-miR-545-002267 4.423923e+05 1.041189e+06 8.804002e+05 3.340875e+05
## 292     hsa-miR-548a-001538 1.884689e+05 1.041189e+06 6.249148e+05 6.795719e+05
## 293  hsa-miR-548a-5p-002412 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 294     hsa-miR-548b-001541 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 295  hsa-miR-548b-5p-002408 3.046233e+05 7.850517e+04 3.781314e+04 1.725873e+05
## 296     hsa-miR-548c-001590 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 297  hsa-miR-548c-5p-002429 3.948012e+05 2.244446e+05 2.159593e+05 6.795719e+05
## 298     hsa-miR-548d-001605 1.435004e+04 1.277886e+05 1.842238e+05 6.795719e+05
## 299  hsa-miR-548d-5p-002237 1.525864e+05 8.906062e+04 6.809683e+04 4.359994e+05
## 300     hsa-miR-551b-001535 3.122398e+04 1.278595e+05 1.718869e+05 4.177831e+04
## 301   hsa-miR-556-3p-002345 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 302   hsa-miR-556-5p-002344 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 303      hsa-miR-561-001528 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 304      hsa-miR-570-002347 8.040728e+05 2.331179e+05 2.252551e+05 6.795719e+05
## 305   hsa-miR-574-3p-002349 2.003522e+01 2.038692e+02 2.097897e+02 1.919112e+01
## 306   hsa-miR-576-3p-002351 2.101551e+04 1.717473e+04 1.350120e+04 1.742736e+04
## 307   hsa-miR-576-5p-002350 1.861873e+04 1.041189e+06 8.804002e+05 6.795719e+05
## 308      hsa-miR-579-002398 1.229656e+04 1.477940e+04 1.327110e+04 1.035447e+04
## 309   hsa-miR-582-3p-002399 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 310   hsa-miR-582-5p-001983 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 311      hsa-miR-589-002409 2.884966e+04 4.466014e+04 7.771471e+04 6.993207e+04
## 312   hsa-miR-590-5p-001984 3.032237e+03 7.340324e+02 3.796168e+02 1.327381e+03
## 313      hsa-miR-597-001551 5.303903e+04 3.443051e+04 3.603722e+04 2.184123e+04
## 314      hsa-miR-598-001988 1.182453e+03 7.883934e+03 6.743585e+03 1.169817e+03
## 315   hsa-miR-615-5p-002353 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 316      hsa-miR-616-002414 2.884766e+04 1.909358e+04 1.359417e+04 8.500539e+04
## 317      hsa-miR-618-001593 5.122622e+03 1.047600e+04 1.074740e+04 1.054643e+04
## 318      hsa-miR-624-002430 8.040728e+05 3.004631e+04 9.697330e+04 6.795719e+05
## 319      hsa-miR-625-002431 3.836935e+04 3.351056e+03 6.652127e+03 8.857836e+04
## 320      hsa-miR-627-001560 4.911713e+05 5.464765e+05 3.985773e+05 1.232191e+05
## 321   hsa-miR-628-5p-002433 3.466987e+03 1.520860e+04 1.249618e+04 2.573947e+03
## 322      hsa-miR-629-002436 6.916079e+04 2.285306e+04 4.055522e+04 6.276474e+04
## 323      hsa-miR-636-002088 2.230635e+04 1.085747e+04 1.146620e+04 2.805104e+04
## 324      hsa-miR-642-001592 9.252751e+03 1.092541e+04 1.361302e+04 1.046124e+04
## 325      hsa-miR-651-001604 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 326      hsa-miR-652-002352 3.140256e+03 1.679016e+03 1.774258e+03 5.148608e+03
## 327      hsa-miR-653-002292 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 328      hsa-miR-654-001611 8.921650e+02 9.166149e+03 8.804002e+05 8.094323e+02
## 329   hsa-miR-654-3p-002239 1.142073e+04 2.533549e+05 9.387153e+04 7.268121e+03
## 330      hsa-miR-655-001612 7.479856e+02 1.432552e+04 1.371817e+04 6.531482e+02
## 331      hsa-miR-660-001515 4.543520e+02 1.135569e+03 1.610061e+03 4.900098e+02
## 332   hsa-miR-671-3p-002322 2.586466e+03 6.637978e+02 8.462265e+02 2.356723e+03
## 333      hsa-miR-672-002327 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 334      hsa-miR-674-002021 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 335      hsa-miR-708-002341 2.754485e+03 6.951594e+02 5.493569e+02 1.290189e+03
## 336      hsa-miR-744-002324 2.723025e+02 1.681228e+03 1.681811e+03 2.166867e+02
## 337      hsa-miR-758-001990 2.321379e+03 2.074247e+04 2.780005e+04 2.275025e+03
## 338      hsa-miR-871-002354 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 339      hsa-miR-872-002264 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 340      hsa-miR-873-002356 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 341   hsa-miR-875-3p-002204 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 342   hsa-miR-876-3p-002225 8.040728e+05 1.928741e+05 2.898406e+05 6.795719e+05
## 343   hsa-miR-876-5p-002205 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 344   hsa-miR-885-3p-002372 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 345   hsa-miR-885-5p-002296 1.091132e+05 4.349916e+04 3.602473e+04 6.854038e+04
## 346   hsa-miR-886-3p-002194 6.954325e+02 3.787757e+02 4.195794e+02 6.447369e+02
## 347   hsa-miR-886-5p-002193 4.246524e+03 2.796100e+03 3.352915e+03 3.816585e+03
## 348      hsa-miR-887-002374 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 349      hsa-miR-888-002212 9.816894e+00 9.410687e+00 6.957649e+00 1.833803e+01
## 350      hsa-miR-889-002202 1.433043e+03 1.580945e+04 2.770579e+04 1.276402e+03
## 351      hsa-miR-890-002209 2.905290e+03 6.103530e+02 3.369288e+02 1.478652e+03
## 352     hsa-miR-891a-002191 8.040728e+05 6.091880e+04 7.648027e+04 6.795719e+05
## 353     hsa-miR-891b-002210 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 354     hsa-miR-892a-002195 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 355        hsa-miR-9-000583 3.905086e+04 2.719934e+01 2.335404e+01 2.470759e+04
## 356      hsa-miR-92a-000431 3.174238e+02 4.050421e+01 3.828480e+01 3.218772e+02
## 357       hsa-miR-95-000433 8.095691e+04 1.041189e+06 8.804002e+05 2.465456e+04
## 358       hsa-miR-98-000577 8.040728e+05 1.041189e+06 8.804002e+05 2.825931e+05
## 359      hsa-miR-99a-000435 2.934606e+00 3.024507e+00 1.548316e+00 1.711388e+00
## 360      hsa-miR-99b-000436 2.854501e+01 2.779782e+01 2.467366e+01 3.948593e+01
##           DCT_T2       DCT_T3
## 1   9.688184e+05 8.646360e+05
## 2   2.229065e+01 5.039586e+01
## 3   5.048542e+00 1.289941e+01
## 4   1.153414e+02 4.186014e+02
## 5   6.830724e+01 1.013171e+02
## 6   4.528605e+00 9.715804e+00
## 7   2.354483e+02 8.074524e+02
## 8   1.164016e+02 1.819166e+02
## 9   1.057917e+05 3.291381e+05
## 10  3.720681e+00 1.600956e+00
## 11  1.940400e+04 2.678678e+04
## 12  2.403123e+02 1.080088e+03
## 13  9.688184e+05 1.187742e+04
## 14  1.074906e+02 1.219260e+01
## 15  9.214529e+02 4.204916e+02
## 16  5.395970e+03 2.075302e+04
## 17  3.902532e+02 2.134913e+02
## 18  9.688184e+05 1.579729e+02
## 19  2.229046e+05 2.703111e+04
## 20  1.141281e+04 6.648593e+03
## 21  1.014529e+02 4.605332e+01
## 22  5.889588e+00 3.529425e+00
## 23  1.491858e+02 2.626280e+04
## 24  3.172980e+01 6.210792e+02
## 25  4.636789e+05 4.305536e+05
## 26  3.354232e+03 9.725342e+03
## 27  9.688184e+05 8.646360e+05
## 28  6.141583e+02 1.218790e+03
## 29  1.521909e+03 8.277971e+02
## 30  1.166681e+02 3.428024e+02
## 31  6.038467e+03 1.339432e+04
## 32  6.357477e+04 8.646360e+05
## 33  9.688184e+05 4.719038e+05
## 34  5.822449e+05 6.344687e+03
## 35  9.688184e+05 8.646360e+05
## 36  4.664785e+02 3.784244e+01
## 37  9.688184e+05 8.646360e+05
## 38  2.178722e+03 9.214955e+02
## 39  1.146378e+03 6.756842e+03
## 40  9.688184e+05 2.458014e+05
## 41  9.688184e+05 5.178811e+04
## 42  9.688184e+05 8.646360e+05
## 43  5.759879e+01 5.015693e+03
## 44  2.502841e+00 5.932652e+02
## 45  2.994134e+01 3.015040e+02
## 46  4.463918e+02 4.048752e+02
## 47  7.777067e+05 4.424434e+05
## 48  9.688184e+05 8.646360e+05
## 49  9.688184e+05 8.646360e+05
## 50  6.017459e+04 6.886739e+04
## 51  1.066721e+03 5.626934e+03
## 52  1.726213e+02 7.627325e+02
## 53  2.930109e+04 5.152673e+04
## 54  8.249111e+01 4.140994e+02
## 55  1.843381e+04 8.646360e+05
## 56  1.514123e+03 1.049264e+02
## 57  9.688184e+05 8.646360e+05
## 58  2.295344e+02 5.137282e+01
## 59  4.515352e+01 2.568107e+01
## 60  1.153334e+02 1.177319e+01
## 61  7.048609e+01 1.912788e+02
## 62  1.351051e+03 1.292013e+04
## 63  8.423117e+04 3.931067e+04
## 64  1.169123e+05 5.575190e+04
## 65  1.045782e+03 1.333318e+04
## 66  2.444573e+03 6.372012e+03
## 67  2.938155e+02 6.640432e+02
## 68  9.688184e+05 8.646360e+05
## 69  2.037859e+04 3.252951e+03
## 70  1.443283e+04 3.340002e+03
## 71  2.456708e+05 1.932935e+05
## 72  1.433994e+01 5.731582e+00
## 73  4.711487e+03 3.290140e+03
## 74  9.688184e+05 7.219970e+05
## 75  1.658996e+02 4.125809e+02
## 76  1.981975e+01 4.041540e+01
## 77  5.704429e+03 3.317621e+03
## 78  5.728314e+02 2.650707e+02
## 79  2.428313e+04 1.265575e+05
## 80  9.903501e+01 9.094569e+01
## 81  4.587329e+04 8.646360e+05
## 82  1.036740e+04 8.646360e+05
## 83  2.902384e+01 5.359212e+04
## 84  3.174115e+04 8.646360e+05
## 85  1.141462e+03 4.185724e+02
## 86  4.076521e+01 6.489167e+00
## 87  9.688184e+05 8.646360e+05
## 88  5.757659e+03 7.288132e+03
## 89  1.017538e+03 5.442906e+02
## 90  1.322737e+05 8.646360e+05
## 91  2.796368e+04 6.176942e+05
## 92  3.215142e+03 4.155659e+02
## 93  9.688184e+05 8.646360e+05
## 94  9.688184e+05 8.646360e+05
## 95  9.688184e+05 8.646360e+05
## 96  2.315479e+02 2.300273e+01
## 97  1.976273e+03 2.727307e+02
## 98  9.267413e+00 1.155570e+01
## 99  1.662565e+02 2.506380e+01
## 100 9.688184e+05 8.646360e+05
## 101 1.668304e+03 4.329646e+03
## 102 5.767470e+01 8.646360e+05
## 103 1.326042e+05 3.710591e+03
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## 115 2.913874e+01 2.599988e+01
## 116 3.158778e+00 1.503926e+00
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## 123 4.043035e+01 4.234833e+01
## 124 2.254192e+02 6.279184e+02
## 125 8.456370e+01 2.098091e+02
## 126 1.618111e+02 8.191781e+02
## 127 5.182005e+02 6.683840e+02
## 128 3.375756e+02 2.064764e+02
## 129 9.620491e+02 1.328757e+02
## 130 2.696758e+05 4.961997e+04
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## 133 1.162036e+04 1.024197e+05
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## 141 2.541427e+01 3.116514e+00
## 142 2.107070e+01 2.310981e+01
## 143 1.425174e+01 2.528541e+01
## 144 1.334814e+01 8.646360e+05
## 145 9.658681e+05 4.153400e+05
## 146 5.565605e+01 5.240503e+01
## 147 1.243996e+03 2.677378e+04
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## 150 9.688184e+05 8.646360e+05
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## 152 3.138577e+02 8.225921e+02
## 153 1.328460e+04 2.616962e+05
## 154 2.296095e+03 1.297128e+04
## 155 9.688184e+05 8.646360e+05
## 156 4.033797e+01 4.161712e+02
## 157 1.074396e+05 2.043855e+05
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## 343 9.688184e+05 8.646360e+05
## 344 9.688184e+05 8.646360e+05
## 345 6.393271e+04 4.252529e+04
## 346 1.807859e+03 3.263177e+02
## 347 2.781537e+03 3.069171e+03
## 348 9.688184e+05 8.646360e+05
## 349 3.731011e+00 2.025398e+01
## 350 1.843417e+03 7.930000e+04
## 351 3.253026e+03 3.989415e+02
## 352 9.688184e+05 1.062154e+05
## 353 9.688184e+05 8.646360e+05
## 354 9.688184e+05 8.646360e+05
## 355 1.338720e+04 2.570778e+01
## 356 8.592694e+02 5.115961e+01
## 357 2.299395e+04 1.639883e+05
## 358 9.688184e+05 8.646360e+05
## 359 2.153624e+00 1.595527e+00
## 360 2.980261e+01 2.624250e+01
promedio_genes <- DCT %>% 
  mutate(Mean_DCT_Cx=(DCT_C1+DCT_C2+DCT_C3)/3,
         Mean_DCT_Tx=(DCT_T1+DCT_T2+DCT_T3)/3)

promedio_genes
##                         Gen       DCT_C1       DCT_C2       DCT_C3       DCT_T1
## 1        ath-miR159a-000338 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 2         hsa-let-7a-000377 3.456564e+01 6.368581e+01 5.400795e+01 2.702582e+01
## 3         hsa-let-7b-002619 7.843332e+00 1.624924e+01 1.477002e+01 6.187543e+00
## 4         hsa-let-7c-000379 1.111271e+02 4.106883e+02 3.681373e+02 1.561693e+02
## 5         hsa-let-7d-002283 1.119543e+02 2.034316e+02 9.793822e+01 8.131033e+01
## 6         hsa-let-7e-002406 5.999601e+00 1.042012e+01 9.286275e+00 5.227665e+00
## 7         hsa-let-7f-000382 5.250339e+02 1.133525e+03 6.844494e+02 2.796477e+02
## 8         hsa-let-7g-002282 1.038003e+02 1.388227e+02 1.518602e+02 1.014248e+02
## 9          hsa-miR-1-002222 6.649539e+04 2.472995e+05 1.512735e+05 1.668355e+05
## 10       hsa-miR-100-000437 3.485019e+00 2.565962e+00 2.007778e+00 2.438623e+00
## 11       hsa-miR-101-002253 1.068476e+04 4.476861e+04 4.187495e+04 1.038538e+04
## 12       hsa-miR-103-000439 2.118893e+02 1.333960e+03 1.179288e+03 1.997798e+02
## 13       hsa-miR-105-002167 8.040728e+05 1.152916e+04 1.064361e+04 6.795719e+05
## 14      hsa-miR-106a-002169 5.918529e+01 1.365540e+01 1.180642e+01 4.036594e+01
## 15      hsa-miR-106b-000442 3.846938e+02 3.892626e+02 3.590398e+02 2.859000e+02
## 16       hsa-miR-107-000443 5.337937e+03 2.109188e+04 2.813347e+04 4.925200e+03
## 17       hsa-miR-10a-000387 5.774558e+02 2.832437e+02 2.629783e+02 1.537845e+02
## 18       hsa-miR-10b-002218 8.040728e+05 1.269309e+02 1.381316e+02 6.795719e+05
## 19       hsa-miR-122-002245 8.040728e+05 8.168186e+03 1.136728e+04 6.795719e+05
## 20   hsa-miR-125a-3p-002199 1.047140e+04 5.766179e+03 5.762583e+03 1.236407e+04
## 21   hsa-miR-125a-5p-002198 1.696911e+02 5.132180e+01 5.167878e+01 1.637631e+02
## 22      hsa-miR-125b-000449 4.788144e+00 3.935918e+00 3.600008e+00 5.041897e+00
## 23       hsa-miR-126-002228 1.516568e+02 2.387644e+04 1.946777e+04 1.638767e+02
## 24       hsa-miR-127-000452 2.408673e+01 7.766388e+02 8.257149e+02 1.872335e+01
## 25    hsa-miR-127-5p-002229 2.558904e+05 1.041189e+06 8.804002e+05 1.256862e+05
## 26      hsa-miR-128a-002216 2.359993e+03 7.914596e+03 6.730043e+03 2.333964e+03
## 27       hsa-miR-129-000590 8.040728e+05 7.529300e+03 7.853391e+03 6.795719e+05
## 28      hsa-miR-130a-000454 4.990244e+02 2.937351e+03 1.391669e+03 2.486317e+02
## 29      hsa-miR-130b-000456 8.765950e+02 8.142342e+02 8.452885e+02 6.526957e+02
## 30       hsa-miR-132-000457 2.728694e+02 4.729028e+02 2.705029e+02 1.423863e+02
## 31      hsa-miR-133a-002246 8.556272e+03 1.344703e+04 1.191507e+04 1.038178e+04
## 32      hsa-miR-133b-002247 2.107198e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 33      hsa-miR-135a-000460 5.461231e+05 1.041189e+06 3.980251e+05 8.242913e+04
## 34      hsa-miR-135b-002261 1.987775e+04 6.815010e+03 6.136073e+03 4.079110e+04
## 35       hsa-miR-136-000592 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 36       hsa-miR-138-002284 8.764298e+01 4.465965e+01 4.036128e+01 6.677641e+01
## 37    hsa-miR-139-3p-002313 8.040728e+05 1.110659e+03 3.102682e+03 6.795719e+05
## 38    hsa-miR-139-5p-002289 2.420965e+03 8.908878e+02 8.337667e+02 2.001362e+03
## 39    hsa-miR-140-3p-002234 1.005270e+03 3.950994e+03 6.236842e+03 2.607708e+03
## 40       hsa-miR-141-000463 8.040728e+05 4.912167e+05 1.318465e+05 3.316189e+05
## 41    hsa-miR-142-3p-000464 4.789338e+05 1.088740e+05 9.808195e+04 6.748778e+05
## 42    hsa-miR-142-5p-002248 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 43       hsa-miR-143-002249 4.054822e+01 7.993990e+03 8.965075e+03 3.845413e+01
## 44       hsa-miR-145-002278 2.966099e+00 1.182890e+03 1.355773e+03 3.200876e+00
## 45      hsa-miR-146a-000468 1.717891e+01 2.518463e+02 2.912068e+02 2.066714e+01
## 46      hsa-miR-146b-001097 4.519648e+02 3.435080e+02 3.607361e+02 5.241975e+02
## 47   hsa-miR-146b-3p-002361 3.345807e+04 1.041189e+06 5.834300e+05 1.242053e+05
## 48       hsa-miR-147-000469 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 49      hsa-miR-147b-002262 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 50      hsa-miR-148a-000470 1.357099e+05 1.041189e+06 4.546510e+05 3.707006e+04
## 51      hsa-miR-148b-000471 6.340561e+02 3.803205e+03 3.526203e+03 5.225288e+02
## 52       hsa-miR-149-002255 9.650064e+01 5.901754e+02 7.223729e+02 9.271730e+01
## 53       hsa-miR-150-000473 6.769523e+04 2.510348e+04 2.390956e+04 3.991011e+04
## 54       hsa-miR-152-000475 9.377729e+01 5.317116e+02 3.851029e+02 8.094481e+01
## 55       hsa-miR-154-000477 2.794430e+04 1.041189e+06 8.804002e+05 1.375403e+04
## 56       hsa-miR-155-002623 8.736833e+02 8.104774e+01 7.709151e+01 1.113717e+03
## 57       hsa-miR-15a-000389 1.579187e+03 1.041189e+06 8.804002e+05 1.420878e+03
## 58       hsa-miR-15b-000390 1.304241e+02 4.914252e+01 5.052761e+01 1.205649e+02
## 59        hsa-miR-16-000391 4.049205e+01 2.457807e+01 1.849547e+01 3.766276e+01
## 60        hsa-miR-17-002308 5.476061e+01 1.327831e+01 1.025389e+01 3.735596e+01
## 61      hsa-miR-181a-000480 1.053077e+02 2.305922e+02 2.211528e+02 1.096808e+02
## 62      hsa-miR-181c-000482 2.878630e+03 2.226670e+04 1.289389e+04 1.791518e+03
## 63       hsa-miR-182-002334 2.591929e+05 3.149205e+04 4.324663e+04 6.795719e+05
## 64       hsa-miR-183-002269 8.040728e+05 4.132136e+04 7.501544e+04 6.795719e+05
## 65       hsa-miR-184-000485 7.466760e+03 1.175185e+04 8.799464e+03 5.186576e+03
## 66       hsa-miR-185-002271 2.222344e+03 4.219335e+03 4.844728e+03 2.121791e+03
## 67       hsa-miR-186-002285 1.441911e+03 2.000022e+03 5.852868e+02 3.329511e+02
## 68    hsa-miR-188-3p-002106 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 69       hsa-miR-18a-002422 2.303109e+03 2.538745e+03 2.551624e+03 2.439664e+03
## 70       hsa-miR-18b-002217 1.090494e+03 2.845961e+03 2.238785e+03 1.423441e+03
## 71       hsa-miR-190-000489 1.376044e+05 1.041189e+06 4.452944e+05 2.565170e+04
## 72       hsa-miR-191-002299 2.328238e+01 5.864874e+00 5.550816e+00 2.055998e+01
## 73       hsa-miR-192-000491 7.460035e+03 3.681811e+03 2.749207e+03 2.643561e+03
## 74   hsa-miR-193a-3p-002250 1.240332e+05 6.529441e+05 4.092435e+05 1.696459e+05
## 75   hsa-miR-193a-5p-002281 1.457717e+02 5.571029e+02 5.464327e+02 1.619570e+02
## 76      hsa-miR-193b-002367 1.405651e+01 4.050421e+01 5.134315e+01 1.437776e+01
## 77       hsa-miR-194-000493 5.972696e+03 3.882580e+03 3.096451e+03 4.904080e+03
## 78       hsa-miR-195-000494 1.116345e+03 4.435337e+02 2.532643e+02 4.610140e+02
## 79      hsa-miR-196b-002215 2.547754e+05 7.737072e+04 1.058015e+05 1.721214e+05
## 80       hsa-miR-197-000497 9.200030e+01 1.297059e+02 9.920219e+01 8.513419e+01
## 81       hsa-miR-198-002273 8.754072e+04 1.041189e+06 8.804002e+05 8.206427e+04
## 82      hsa-miR-199a-000498 5.960703e+03 1.041189e+06 8.804002e+05 4.793510e+03
## 83   hsa-miR-199a-3p-002304 1.892035e+01 6.933518e+04 8.006033e+04 2.041230e+01
## 84      hsa-miR-199b-000500 5.245769e+04 2.358157e+05 8.804002e+05 1.759608e+04
## 85       hsa-miR-19a-000395 3.045144e+02 4.314352e+02 3.458733e+02 3.007178e+02
## 86       hsa-miR-19b-000396 1.233398e+01 5.758528e+00 4.918778e+00 1.039968e+01
## 87      hsa-miR-200a-000502 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 88      hsa-miR-200b-002251 1.075013e+04 7.052896e+03 3.865395e+03 1.092667e+04
## 89      hsa-miR-200c-002300 1.849048e+03 3.752739e+02 4.220880e+02 2.052216e+03
## 90       hsa-miR-202-002363 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 91       hsa-miR-203-000507 5.925571e+04 2.436752e+05 1.623446e+05 4.263547e+04
## 92       hsa-miR-204-000508 4.110695e+03 5.103347e+02 3.978277e+02 2.052927e+03
## 93       hsa-miR-205-000509 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 94       hsa-miR-208-000511 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 95      hsa-miR-208b-002290 8.040728e+05 1.041189e+06 8.804002e+05 7.972622e+04
## 96       hsa-miR-20a-000580 1.112350e+02 2.142762e+01 2.128109e+01 7.809545e+01
## 97       hsa-miR-20b-001014 9.114797e+02 3.466894e+02 2.073178e+02 6.427290e+02
## 98        hsa-miR-21-000397 6.382257e+00 1.003870e+01 8.333947e+00 5.788809e+00
## 99       hsa-miR-210-000512 3.465132e+02 3.787043e+01 3.389969e+01 3.140753e+02
## 100      hsa-miR-211-000514 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 101      hsa-miR-212-000515 2.830158e+03 5.361794e+03 2.803280e+03 1.748942e+03
## 102      hsa-miR-214-002306 3.847013e+01 1.041189e+06 8.804002e+05 4.078217e+01
## 103      hsa-miR-215-000518 8.040728e+05 2.882890e+03 1.437554e+03 6.795719e+05
## 104     hsa-miR-216a-002220 8.040728e+05 1.041189e+06 8.804002e+05 6.743166e+05
## 105     hsa-miR-216b-002326 8.040728e+05 1.041189e+06 2.555773e+05 6.795719e+05
## 106      hsa-miR-217-002337 4.201563e+05 1.041189e+06 8.804002e+05 1.828456e+05
## 107      hsa-miR-218-000521 2.936119e+02 4.152108e+02 3.525050e+02 2.739686e+02
## 108      hsa-miR-219-000522 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 109 hsa-miR-219-1-3p-002095 3.078924e+05 2.481065e+05 8.781014e+04 4.152632e+05
## 110 hsa-miR-219-2-3p-002390 5.531101e+00 1.041189e+06 8.804002e+05 6.795719e+05
## 111       hsa-miR-22-000398 6.606282e+01 1.827592e+02 1.913938e+02 8.078786e+01
## 112      hsa-miR-220-000523 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 113     hsa-miR-220b-002206 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 114     hsa-miR-220c-002211 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 115      hsa-miR-221-000524 1.642665e+01 2.453042e+01 2.554201e+01 1.545891e+01
## 116      hsa-miR-222-002276 4.425274e+00 2.142210e+00 1.575708e+00 2.509268e+00
## 117      hsa-miR-223-002295 1.112229e+04 1.201043e+04 8.428148e+03 1.034587e+04
## 118      hsa-miR-224-002099 5.813111e+02 3.784796e+03 6.881465e+03 6.663178e+02
## 119      hsa-miR-23a-000399 6.636114e+01 1.355518e+02 2.075334e+02 7.209197e+01
## 120      hsa-miR-23b-000400 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 121       hsa-miR-24-000402 7.578933e-01 8.033340e+00 5.896259e+00 5.719126e-01
## 122       hsa-miR-25-000403 1.652995e+03 3.682138e+02 3.155227e+02 9.009896e+02
## 123      hsa-miR-26a-000405 5.175645e+01 6.046381e+01 4.028861e+01 3.971375e+01
## 124      hsa-miR-26b-000407 1.150118e+03 2.054398e+03 5.390592e+02 1.918542e+02
## 125      hsa-miR-27a-000408 4.165641e+01 2.326149e+02 2.108247e+02 3.713137e+01
## 126      hsa-miR-27b-000409 1.581080e+02 1.005153e+03 7.703659e+02 1.628914e+02
## 127       hsa-miR-28-000411 3.789508e+02 7.127736e+02 6.824124e+02 3.247007e+02
## 128    hsa-miR-28-3p-002446 3.756295e+02 2.434025e+02 2.073609e+02 2.607397e+02
## 129      hsa-miR-296-000527 1.113871e+03 2.231237e+02 1.248455e+02 6.467510e+02
## 130   hsa-miR-296-3p-002101 1.158314e+05 3.138309e+04 2.871068e+04 9.299507e+04
## 131      hsa-miR-298-002190 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 132   hsa-miR-299-3p-001015 8.040728e+05 1.041189e+06 8.804002e+05 4.277969e+05
## 133   hsa-miR-299-5p-000600 5.584323e+03 4.300366e+05 3.363258e+05 4.289419e+03
## 134      hsa-miR-29a-002112 5.324945e+00 1.378787e+00 1.358580e+00 4.933347e+00
## 135      hsa-miR-29b-000413 3.734156e+03 5.135539e+03 5.314064e+03 3.117917e+03
## 136      hsa-miR-29c-000587 8.774290e+03 1.715365e+03 2.122617e+02 5.368468e+02
## 137      hsa-miR-301-000528 1.467115e+03 2.870869e+04 3.108864e+04 1.426206e+03
## 138     hsa-miR-301b-002392 6.370711e+04 5.410866e+05 4.519489e+05 4.452619e+04
## 139     hsa-miR-302a-000529 2.476637e+03 6.801663e+04 4.928975e+04 1.929307e+03
## 140     hsa-miR-302b-000531 2.145156e+03 1.041189e+06 1.509070e+05 3.921513e+02
## 141     hsa-miR-302c-000533 2.712717e+01 1.187372e+01 4.753203e+00 2.395021e+01
## 142      hsa-miR-30b-000602 2.336969e+01 2.751221e+01 2.647392e+01 2.018297e+01
## 143      hsa-miR-30c-000419 1.509048e+01 2.198427e+01 2.183544e+01 1.496652e+01
## 144       hsa-miR-31-002279 5.972217e+00 1.041189e+06 8.804002e+05 5.086124e+00
## 145       hsa-miR-32-002109 1.345485e+05 1.322034e+05 2.309146e+05 1.863386e+05
## 146      hsa-miR-320-002277 5.006279e+01 4.936443e+01 5.008477e+01 4.043595e+01
## 147   hsa-miR-323-3p-002227 5.712057e+02 5.150411e+04 2.271094e+04 6.629088e+02
## 148   hsa-miR-324-3p-002161 5.295660e+02 1.013198e+03 1.086370e+03 5.144427e+02
## 149   hsa-miR-324-5p-000539 1.399375e+03 6.806512e+03 6.120357e+03 1.074364e+03
## 150      hsa-miR-325-000540 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 151      hsa-miR-326-000542 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 152      hsa-miR-328-000543 3.011350e+02 1.407091e+03 1.065267e+03 2.129937e+02
## 153      hsa-miR-329-001101 1.718744e+04 9.519512e+04 1.778005e+05 9.988599e+03
## 154      hsa-miR-330-000544 2.492654e+03 1.715094e+04 2.353467e+04 1.936676e+03
## 155   hsa-miR-330-5p-002230 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 156      hsa-miR-331-000545 2.857470e+01 3.193733e+02 3.112219e+02 2.725533e+01
## 157   hsa-miR-331-5p-002233 9.780134e+04 6.521427e+04 2.126469e+05 7.142625e+04
## 158      hsa-miR-335-000546 4.654127e+02 6.856365e+02 6.402538e+02 3.391469e+02
## 159   hsa-miR-337-5p-002156 1.906177e+03 2.303711e+05 2.186858e+05 2.153200e+03
## 160   hsa-miR-338-3p-002252 8.040728e+05 2.104474e+05 8.804002e+05 6.795719e+05
## 161   hsa-miR-339-3p-002184 9.956305e+02 9.305243e+02 8.428313e+02 1.010439e+03
## 162   hsa-miR-339-5p-002257 2.365115e+02 4.235534e+02 3.636735e+02 1.853190e+02
## 163      hsa-miR-33b-002085 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 164      hsa-miR-340-002258 1.087906e+04 9.163886e+05 8.364385e+05 1.048084e+04
## 165   hsa-miR-342-3p-002260 1.572010e+02 5.243186e+02 7.642496e+02 2.387351e+02
## 166   hsa-miR-342-5p-002147 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 167      hsa-miR-345-002186 5.303742e+02 3.487381e+02 3.557451e+02 5.243792e+02
## 168      hsa-miR-346-000553 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 169      hsa-miR-34a-000426 1.146400e+02 9.014028e+01 8.210510e+01 1.123508e+02
## 170      hsa-miR-34c-000428 5.781254e+03 2.747820e+04 1.287960e+04 4.946412e+03
## 171      hsa-miR-361-000554 2.640447e+03 3.556395e+03 3.063574e+03 1.834621e+03
## 172      hsa-miR-362-001273 2.518356e+03 3.179976e+03 2.731353e+03 2.577696e+03
## 173   hsa-miR-362-3p-002117 2.074199e+04 4.130131e+04 3.920908e+04 1.913686e+04
## 174      hsa-miR-363-001271 2.833832e+04 1.041189e+06 8.804002e+05 2.079237e+04
## 175      hsa-miR-365-001020 5.607814e+01 3.777008e+02 4.259381e+02 8.222850e+01
## 176      hsa-miR-367-000555 5.974585e+01 1.332600e+02 1.058076e+02 3.176721e+01
## 177   hsa-miR-369-3p-000557 1.572136e+05 1.041189e+06 8.804002e+05 2.441985e+04
## 178   hsa-miR-369-5p-001021 2.669102e+04 1.095249e+05 2.405705e+05 4.529822e+04
## 179      hsa-miR-370-002275 8.861424e+01 6.634629e+03 8.582011e+03 8.254258e+01
## 180   hsa-miR-371-3p-002124 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 181      hsa-miR-372-000560 4.920327e+04 5.737362e+04 5.577767e+04 9.976642e+04
## 182      hsa-miR-373-000561 3.338329e+05 1.041189e+06 8.804002e+05 9.449607e+04
## 183      hsa-miR-374-000563 1.316776e+02 4.903269e+02 3.128875e+02 6.308996e+02
## 184      hsa-miR-375-000564 3.951023e+05 5.839673e+04 2.663619e+04 1.231764e+05
## 185     hsa-miR-376a-000565 7.530463e+01 1.485363e+03 1.218086e+03 5.384971e+01
## 186     hsa-miR-376b-001102 5.806378e+01 3.410237e+01 3.295213e+01 8.015756e+01
## 187     hsa-miR-376c-002122 3.865188e+01 9.679576e+02 7.017435e+02 3.832109e+01
## 188      hsa-miR-377-000566 1.476984e+04 1.041189e+06 8.804002e+05 6.795719e+05
## 189   hsa-miR-380-3p-000569 1.275669e+04 1.041189e+06 8.804002e+05 9.368918e+03
## 190      hsa-miR-381-000571 5.777936e+04 9.824333e+05 3.917571e+05 2.043092e+04
## 191      hsa-miR-382-000572 5.389078e+01 2.034982e+03 1.246442e+03 5.865843e+01
## 192      hsa-miR-383-000573 2.772244e+04 1.041189e+06 8.804002e+05 1.977879e+04
## 193      hsa-miR-384-000574 8.040728e+05 2.889435e+04 8.804002e+05 6.795719e+05
## 194   hsa-miR-409-5p-002331 3.564704e+03 5.278352e+04 8.705865e+04 4.919059e+03
## 195      hsa-miR-410-001274 1.636578e+03 9.234204e+04 1.069517e+05 9.330863e+02
## 196      hsa-miR-411-001610 1.098253e+02 3.327447e+03 2.341959e+03 8.129905e+01
## 197      hsa-miR-412-001023 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 198     hsa-miR-422a-002297 1.707581e+04 1.092238e+04 1.304763e+04 1.512625e+04
## 199   hsa-miR-423-5p-002340 4.803488e+03 5.672622e+03 5.843431e+03 5.235700e+03
## 200      hsa-miR-424-000604 6.120945e+04 2.827031e+04 2.628587e+04 3.537559e+04
## 201   hsa-miR-425-5p-001516 1.313014e+03 3.957924e+02 3.739237e+02 1.141857e+03
## 202      hsa-miR-429-001024 2.010600e+05 1.041189e+06 8.804002e+05 1.513644e+05
## 203      hsa-miR-431-001979 1.778684e+02 4.954268e+01 5.465191e+01 1.601929e+02
## 204      hsa-miR-433-001028 1.531327e+03 5.836145e+03 1.394732e+04 1.313196e+03
## 205      hsa-miR-448-001029 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 206      hsa-miR-449-001030 4.584379e+05 7.335095e+03 1.029888e+04 6.521601e+05
## 207     hsa-miR-449b-001608 3.920741e+05 4.751278e+03 5.132336e+03 4.450151e+04
## 208     hsa-miR-450a-002303 2.762078e+04 3.569415e+04 5.503264e+04 4.168575e+04
## 209  hsa-miR-450b-3p-002208 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 210  hsa-miR-450b-5p-002207 1.824982e+03 1.041189e+06 8.804002e+05 6.795719e+05
## 211      hsa-miR-452-002329 1.654256e+03 1.041189e+06 8.804002e+05 1.323339e+03
## 212      hsa-miR-453-002318 2.572420e+05 1.041189e+06 8.804002e+05 1.138967e+05
## 213      hsa-miR-454-002323 4.296943e+02 8.154768e+02 6.043330e+02 2.708719e+02
## 214      hsa-miR-455-001280 1.367066e+03 2.910598e+03 3.213434e+03 1.315747e+03
## 215   hsa-miR-455-3p-002244 8.336897e+02 5.133859e+02 5.540990e+02 6.521078e+02
## 216   hsa-miR-483-5p-002338 9.209062e+04 1.101798e+05 5.220861e+04 4.124886e+04
## 217      hsa-miR-484-001821 3.580941e+01 4.267739e+01 4.194422e+01 3.208810e+01
## 218   hsa-miR-485-3p-001277 5.949673e+02 2.233007e+04 1.895643e+04 5.565111e+02
## 219   hsa-miR-485-5p-001036 7.584271e+02 1.041189e+06 8.804002e+05 4.189885e+02
## 220      hsa-miR-486-001278 7.978063e+01 3.100102e+03 1.869323e+03 7.943851e+01
## 221   hsa-miR-486-3p-002093 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 222     hsa-miR-487a-001279 3.656548e+03 6.106254e+04 8.804002e+05 2.707915e+03
## 223     hsa-miR-487b-001285 3.770643e+02 1.653689e+04 2.281192e+04 3.280261e+02
## 224      hsa-miR-488-002357 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 225      hsa-miR-489-002358 1.703562e+04 1.587754e+04 1.363474e+04 1.023885e+04
## 226      hsa-miR-490-001037 7.489941e+04 1.041189e+06 8.804002e+05 1.410449e+04
## 227   hsa-miR-491-3p-002360 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 228      hsa-miR-492-001039 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 229      hsa-miR-493-002364 1.193156e+03 9.708764e+04 1.549024e+05 1.120842e+03
## 230      hsa-miR-494-002365 1.486697e+02 3.301944e+03 3.444312e+03 1.537845e+02
## 231   hsa-miR-499-3p-002427 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 232      hsa-miR-500-002428 6.047263e+03 6.495388e+03 6.755281e+03 5.276138e+03
## 233      hsa-miR-501-001047 2.440171e+03 1.079165e+03 2.270352e+03 1.994023e+03
## 234   hsa-miR-501-3p-002435 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 235      hsa-miR-502-001109 4.912489e+04 8.440261e+04 2.619130e+04 1.162438e+04
## 236   hsa-miR-502-3p-002083 1.199434e+04 1.061341e+04 1.348156e+04 2.035741e+04
## 237      hsa-miR-503-001048 2.491051e+04 3.062241e+04 2.712809e+04 1.983508e+04
## 238      hsa-miR-504-002084 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 239      hsa-miR-505-002089 3.998565e+03 1.041189e+06 7.349855e+03 3.202686e+03
## 240      hsa-miR-506-001050 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 241      hsa-miR-507-001051 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 242      hsa-miR-508-001052 3.013889e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 243   hsa-miR-508-5p-002092 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 244 hsa-miR-509-3-5p-002155 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 245   hsa-miR-509-5p-002235 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 246      hsa-miR-510-002241 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 247      hsa-miR-511-001111 9.212613e+02 1.041189e+06 8.804002e+05 4.439233e+02
## 248   hsa-miR-512-3p-001823 2.314541e+05 4.050825e+03 3.273005e+03 1.519531e+05
## 249   hsa-miR-512-5p-001145 8.040728e+05 1.007257e+06 8.804002e+05 6.795719e+05
## 250   hsa-miR-513-5p-002090 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 251   hsa-miR-515-3p-002369 1.012332e+03 8.525260e+02 6.280780e+02 1.250480e+03
## 252   hsa-miR-515-5p-001112 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 253  hsa-miR-516a-5p-002416 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 254     hsa-miR-516b-001150 8.040728e+05 8.482489e+04 2.156302e+05 6.795719e+05
## 255     hsa-miR-517a-002402 5.036865e+05 7.456588e+03 6.283271e+03 5.077880e+05
## 256     hsa-miR-517b-001152 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 257     hsa-miR-517c-001153 1.235698e+05 9.556721e+03 6.935576e+03 3.884030e+04
## 258  hsa-miR-518a-3p-002397 8.040728e+05 5.619289e+04 9.158349e+04 1.420133e+05
## 259  hsa-miR-518a-5p-002396 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 260     hsa-miR-518b-001156 8.040728e+05 1.660811e+04 1.157801e+04 6.795719e+05
## 261     hsa-miR-518c-002401 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 262     hsa-miR-518d-001159 8.040728e+05 9.864101e+04 8.804002e+05 6.795719e+05
## 263  hsa-miR-518d-5p-002389 7.831381e+00 1.041189e+06 1.454045e+01 6.795719e+05
## 264     hsa-miR-518e-002395 8.040728e+05 3.110157e+04 4.178218e+04 6.795719e+05
## 265     hsa-miR-518f-002388 8.040728e+05 4.540615e+04 2.615139e+04 6.795719e+05
## 266     hsa-miR-519a-002415 2.573847e+05 1.203126e+04 1.351899e+04 1.698694e+05
## 267     hsa-miR-519c-001163 8.040728e+05 5.033143e+05 2.354890e+05 6.795719e+05
## 268     hsa-miR-519d-002403 8.040728e+05 2.242313e+04 2.141153e+04 6.795719e+05
## 269     hsa-miR-519e-002370 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 270    hsa-miR-520a#-001168 8.040728e+05 9.504348e+04 8.804002e+05 6.795719e+05
## 271     hsa-miR-520a-001167 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 272     hsa-miR-520b-001116 8.040728e+05 2.447586e+05 1.883035e+05 5.815593e+05
## 273  hsa-miR-520d-5p-002393 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 274     hsa-miR-520e-001119 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 275     hsa-miR-520f-001120 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 276     hsa-miR-520g-001121 8.040728e+05 1.814897e+04 1.065542e+04 6.795719e+05
## 277      hsa-miR-521-001122 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 278      hsa-miR-522-002413 8.040728e+05 4.856401e+04 5.838864e+04 9.291775e+04
## 279      hsa-miR-523-002386 2.569847e+03 9.127474e+03 6.900705e+02 1.266180e+03
## 280   hsa-miR-524-5p-001982 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 281      hsa-miR-525-001174 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 282   hsa-miR-525-3p-002385 8.040728e+05 9.093827e+04 2.103016e+05 6.795719e+05
## 283     hsa-miR-526b-002382 8.040728e+05 1.041189e+06 5.692600e+04 6.795719e+05
## 284      hsa-miR-532-001518 3.112363e+02 3.610363e+02 4.180118e+02 3.273674e+02
## 285   hsa-miR-532-3p-002355 2.201035e+03 2.647656e+03 3.406324e+03 2.559359e+03
## 286      hsa-miR-539-001286 1.414616e+02 5.317381e+03 6.658585e+03 1.386753e+02
## 287      hsa-miR-541-002201 2.023783e+04 1.041189e+06 8.804002e+05 1.970353e+04
## 288   hsa-miR-542-3p-001284 2.577775e+05 2.633460e+05 1.089495e+05 9.776068e+04
## 289   hsa-miR-542-5p-002240 2.014087e+05 1.041189e+06 2.252238e+05 2.686683e+05
## 290      hsa-miR-544-002265 3.879380e+05 1.041189e+06 8.804002e+05 6.623190e+05
## 291      hsa-miR-545-002267 4.423923e+05 1.041189e+06 8.804002e+05 3.340875e+05
## 292     hsa-miR-548a-001538 1.884689e+05 1.041189e+06 6.249148e+05 6.795719e+05
## 293  hsa-miR-548a-5p-002412 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 294     hsa-miR-548b-001541 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 295  hsa-miR-548b-5p-002408 3.046233e+05 7.850517e+04 3.781314e+04 1.725873e+05
## 296     hsa-miR-548c-001590 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 297  hsa-miR-548c-5p-002429 3.948012e+05 2.244446e+05 2.159593e+05 6.795719e+05
## 298     hsa-miR-548d-001605 1.435004e+04 1.277886e+05 1.842238e+05 6.795719e+05
## 299  hsa-miR-548d-5p-002237 1.525864e+05 8.906062e+04 6.809683e+04 4.359994e+05
## 300     hsa-miR-551b-001535 3.122398e+04 1.278595e+05 1.718869e+05 4.177831e+04
## 301   hsa-miR-556-3p-002345 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 302   hsa-miR-556-5p-002344 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 303      hsa-miR-561-001528 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 304      hsa-miR-570-002347 8.040728e+05 2.331179e+05 2.252551e+05 6.795719e+05
## 305   hsa-miR-574-3p-002349 2.003522e+01 2.038692e+02 2.097897e+02 1.919112e+01
## 306   hsa-miR-576-3p-002351 2.101551e+04 1.717473e+04 1.350120e+04 1.742736e+04
## 307   hsa-miR-576-5p-002350 1.861873e+04 1.041189e+06 8.804002e+05 6.795719e+05
## 308      hsa-miR-579-002398 1.229656e+04 1.477940e+04 1.327110e+04 1.035447e+04
## 309   hsa-miR-582-3p-002399 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 310   hsa-miR-582-5p-001983 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 311      hsa-miR-589-002409 2.884966e+04 4.466014e+04 7.771471e+04 6.993207e+04
## 312   hsa-miR-590-5p-001984 3.032237e+03 7.340324e+02 3.796168e+02 1.327381e+03
## 313      hsa-miR-597-001551 5.303903e+04 3.443051e+04 3.603722e+04 2.184123e+04
## 314      hsa-miR-598-001988 1.182453e+03 7.883934e+03 6.743585e+03 1.169817e+03
## 315   hsa-miR-615-5p-002353 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 316      hsa-miR-616-002414 2.884766e+04 1.909358e+04 1.359417e+04 8.500539e+04
## 317      hsa-miR-618-001593 5.122622e+03 1.047600e+04 1.074740e+04 1.054643e+04
## 318      hsa-miR-624-002430 8.040728e+05 3.004631e+04 9.697330e+04 6.795719e+05
## 319      hsa-miR-625-002431 3.836935e+04 3.351056e+03 6.652127e+03 8.857836e+04
## 320      hsa-miR-627-001560 4.911713e+05 5.464765e+05 3.985773e+05 1.232191e+05
## 321   hsa-miR-628-5p-002433 3.466987e+03 1.520860e+04 1.249618e+04 2.573947e+03
## 322      hsa-miR-629-002436 6.916079e+04 2.285306e+04 4.055522e+04 6.276474e+04
## 323      hsa-miR-636-002088 2.230635e+04 1.085747e+04 1.146620e+04 2.805104e+04
## 324      hsa-miR-642-001592 9.252751e+03 1.092541e+04 1.361302e+04 1.046124e+04
## 325      hsa-miR-651-001604 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 326      hsa-miR-652-002352 3.140256e+03 1.679016e+03 1.774258e+03 5.148608e+03
## 327      hsa-miR-653-002292 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 328      hsa-miR-654-001611 8.921650e+02 9.166149e+03 8.804002e+05 8.094323e+02
## 329   hsa-miR-654-3p-002239 1.142073e+04 2.533549e+05 9.387153e+04 7.268121e+03
## 330      hsa-miR-655-001612 7.479856e+02 1.432552e+04 1.371817e+04 6.531482e+02
## 331      hsa-miR-660-001515 4.543520e+02 1.135569e+03 1.610061e+03 4.900098e+02
## 332   hsa-miR-671-3p-002322 2.586466e+03 6.637978e+02 8.462265e+02 2.356723e+03
## 333      hsa-miR-672-002327 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 334      hsa-miR-674-002021 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 335      hsa-miR-708-002341 2.754485e+03 6.951594e+02 5.493569e+02 1.290189e+03
## 336      hsa-miR-744-002324 2.723025e+02 1.681228e+03 1.681811e+03 2.166867e+02
## 337      hsa-miR-758-001990 2.321379e+03 2.074247e+04 2.780005e+04 2.275025e+03
## 338      hsa-miR-871-002354 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 339      hsa-miR-872-002264 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 340      hsa-miR-873-002356 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 341   hsa-miR-875-3p-002204 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 342   hsa-miR-876-3p-002225 8.040728e+05 1.928741e+05 2.898406e+05 6.795719e+05
## 343   hsa-miR-876-5p-002205 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 344   hsa-miR-885-3p-002372 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 345   hsa-miR-885-5p-002296 1.091132e+05 4.349916e+04 3.602473e+04 6.854038e+04
## 346   hsa-miR-886-3p-002194 6.954325e+02 3.787757e+02 4.195794e+02 6.447369e+02
## 347   hsa-miR-886-5p-002193 4.246524e+03 2.796100e+03 3.352915e+03 3.816585e+03
## 348      hsa-miR-887-002374 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 349      hsa-miR-888-002212 9.816894e+00 9.410687e+00 6.957649e+00 1.833803e+01
## 350      hsa-miR-889-002202 1.433043e+03 1.580945e+04 2.770579e+04 1.276402e+03
## 351      hsa-miR-890-002209 2.905290e+03 6.103530e+02 3.369288e+02 1.478652e+03
## 352     hsa-miR-891a-002191 8.040728e+05 6.091880e+04 7.648027e+04 6.795719e+05
## 353     hsa-miR-891b-002210 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 354     hsa-miR-892a-002195 8.040728e+05 1.041189e+06 8.804002e+05 6.795719e+05
## 355        hsa-miR-9-000583 3.905086e+04 2.719934e+01 2.335404e+01 2.470759e+04
## 356      hsa-miR-92a-000431 3.174238e+02 4.050421e+01 3.828480e+01 3.218772e+02
## 357       hsa-miR-95-000433 8.095691e+04 1.041189e+06 8.804002e+05 2.465456e+04
## 358       hsa-miR-98-000577 8.040728e+05 1.041189e+06 8.804002e+05 2.825931e+05
## 359      hsa-miR-99a-000435 2.934606e+00 3.024507e+00 1.548316e+00 1.711388e+00
## 360      hsa-miR-99b-000436 2.854501e+01 2.779782e+01 2.467366e+01 3.948593e+01
##           DCT_T2       DCT_T3  Mean_DCT_Cx  Mean_DCT_Tx
## 1   9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 2   2.229065e+01 5.039586e+01 5.075313e+01 3.323744e+01
## 3   5.048542e+00 1.289941e+01 1.295420e+01 8.045165e+00
## 4   1.153414e+02 4.186014e+02 2.966509e+02 2.300374e+02
## 5   6.830724e+01 1.013171e+02 1.377747e+02 8.364488e+01
## 6   4.528605e+00 9.715804e+00 8.568666e+00 6.490691e+00
## 7   2.354483e+02 8.074524e+02 7.810026e+02 4.408495e+02
## 8   1.164016e+02 1.819166e+02 1.314944e+02 1.332477e+02
## 9   1.057917e+05 3.291381e+05 1.550228e+05 2.005884e+05
## 10  3.720681e+00 1.600956e+00 2.686253e+00 2.586753e+00
## 11  1.940400e+04 2.678678e+04 3.244278e+04 1.885872e+04
## 12  2.403123e+02 1.080088e+03 9.083791e+02 5.067267e+02
## 13  9.688184e+05 1.187742e+04 2.754152e+05 5.534226e+05
## 14  1.074906e+02 1.219260e+01 2.821570e+01 5.334971e+01
## 15  9.214529e+02 4.204916e+02 3.776654e+02 5.426149e+02
## 16  5.395970e+03 2.075302e+04 1.818776e+04 1.035806e+04
## 17  3.902532e+02 2.134913e+02 3.745593e+02 2.525097e+02
## 18  9.688184e+05 1.579729e+02 2.681126e+05 5.495161e+05
## 19  2.229046e+05 2.703111e+04 2.745361e+05 3.098359e+05
## 20  1.141281e+04 6.648593e+03 7.333387e+03 1.014183e+04
## 21  1.014529e+02 4.605332e+01 9.089721e+01 1.037565e+02
## 22  5.889588e+00 3.529425e+00 4.108023e+00 4.820303e+00
## 23  1.491858e+02 2.626280e+04 1.449862e+04 8.858622e+03
## 24  3.172980e+01 6.210792e+02 5.421468e+02 2.238441e+02
## 25  4.636789e+05 4.305536e+05 7.258264e+05 3.399729e+05
## 26  3.354232e+03 9.725342e+03 5.668211e+03 5.137846e+03
## 27  9.688184e+05 8.646360e+05 2.731518e+05 8.376754e+05
## 28  6.141583e+02 1.218790e+03 1.609348e+03 6.938599e+02
## 29  1.521909e+03 8.277971e+02 8.453726e+02 1.000801e+03
## 30  1.166681e+02 3.428024e+02 3.387584e+02 2.006189e+02
## 31  6.038467e+03 1.339432e+04 1.130612e+04 9.938189e+03
## 32  6.357477e+04 8.646360e+05 7.107696e+05 5.359275e+05
## 33  9.688184e+05 4.719038e+05 6.617789e+05 5.077171e+05
## 34  5.822449e+05 6.344687e+03 1.094294e+04 2.097936e+05
## 35  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 36  4.664785e+02 3.784244e+01 5.755464e+01 1.903658e+02
## 37  9.688184e+05 8.646360e+05 2.694287e+05 8.376754e+05
## 38  2.178722e+03 9.214955e+02 1.381873e+03 1.700527e+03
## 39  1.146378e+03 6.756842e+03 3.731035e+03 3.503642e+03
## 40  9.688184e+05 2.458014e+05 4.757120e+05 5.154129e+05
## 41  9.688184e+05 5.178811e+04 2.286299e+05 5.651614e+05
## 42  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 43  5.759879e+01 5.015693e+03 5.666538e+03 1.703915e+03
## 44  2.502841e+00 5.932652e+02 8.472097e+02 1.996563e+02
## 45  2.994134e+01 3.015040e+02 1.867440e+02 1.173708e+02
## 46  4.463918e+02 4.048752e+02 3.854030e+02 4.584881e+02
## 47  7.777067e+05 4.424434e+05 5.526922e+05 4.481185e+05
## 48  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 49  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 50  6.017459e+04 6.886739e+04 5.438498e+05 5.537068e+04
## 51  1.066721e+03 5.626934e+03 2.654488e+03 2.405394e+03
## 52  1.726213e+02 7.627325e+02 4.696830e+02 3.426904e+02
## 53  2.930109e+04 5.152673e+04 3.890276e+04 4.024598e+04
## 54  8.249111e+01 4.140994e+02 3.368639e+02 1.925118e+02
## 55  1.843381e+04 8.646360e+05 6.498444e+05 2.989413e+05
## 56  1.514123e+03 1.049264e+02 3.439409e+02 9.109220e+02
## 57  9.688184e+05 8.646360e+05 6.410560e+05 6.116251e+05
## 58  2.295344e+02 5.137282e+01 7.669808e+01 1.338241e+02
## 59  4.515352e+01 2.568107e+01 2.785520e+01 3.616578e+01
## 60  1.153334e+02 1.177319e+01 2.609761e+01 5.482085e+01
## 61  7.048609e+01 1.912788e+02 1.856842e+02 1.238152e+02
## 62  1.351051e+03 1.292013e+04 1.267974e+04 5.354234e+03
## 63  8.423117e+04 3.931067e+04 1.113105e+05 2.677046e+05
## 64  1.169123e+05 5.575190e+04 3.068032e+05 2.840787e+05
## 65  1.045782e+03 1.333318e+04 9.339357e+03 6.521846e+03
## 66  2.444573e+03 6.372012e+03 3.762136e+03 3.646125e+03
## 67  2.938155e+02 6.640432e+02 1.342407e+03 4.302700e+02
## 68  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 69  2.037859e+04 3.252951e+03 2.464493e+03 8.690402e+03
## 70  1.443283e+04 3.340002e+03 2.058413e+03 6.398758e+03
## 71  2.456708e+05 1.932935e+05 5.413625e+05 1.548720e+05
## 72  1.433994e+01 5.731582e+00 1.156602e+01 1.354383e+01
## 73  4.711487e+03 3.290140e+03 4.630351e+03 3.548396e+03
## 74  9.688184e+05 7.219970e+05 3.954069e+05 6.201537e+05
## 75  1.658996e+02 4.125809e+02 4.164358e+02 2.468125e+02
## 76  1.981975e+01 4.041540e+01 3.530129e+01 2.487097e+01
## 77  5.704429e+03 3.317621e+03 4.317243e+03 4.642043e+03
## 78  5.728314e+02 2.650707e+02 6.043809e+02 4.329720e+02
## 79  2.428313e+04 1.265575e+05 1.459825e+05 1.076540e+05
## 80  9.903501e+01 9.094569e+01 1.069695e+02 9.170496e+01
## 81  4.587329e+04 8.646360e+05 6.697099e+05 3.308578e+05
## 82  1.036740e+04 8.646360e+05 6.425165e+05 2.932656e+05
## 83  2.902384e+01 5.359212e+04 4.980481e+04 1.788052e+04
## 84  3.174115e+04 8.646360e+05 3.895579e+05 3.046577e+05
## 85  1.141462e+03 4.185724e+02 3.606076e+02 6.202506e+02
## 86  4.076521e+01 6.489167e+00 7.670429e+00 1.921802e+01
## 87  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 88  5.757659e+03 7.288132e+03 7.222807e+03 7.990822e+03
## 89  1.017538e+03 5.442906e+02 8.821365e+02 1.204681e+03
## 90  1.322737e+05 8.646360e+05 9.085539e+05 5.588272e+05
## 91  2.796368e+04 6.176942e+05 1.550918e+05 2.294311e+05
## 92  3.215142e+03 4.155659e+02 1.672953e+03 1.894545e+03
## 93  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 94  9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 95  9.688184e+05 8.646360e+05 9.085539e+05 6.377268e+05
## 96  2.315479e+02 2.300273e+01 5.131456e+01 1.108820e+02
## 97  1.976273e+03 2.727307e+02 4.884956e+02 9.639109e+02
## 98  9.267413e+00 1.155570e+01 8.251633e+00 8.870642e+00
## 99  1.662565e+02 2.506380e+01 1.394278e+02 1.684652e+02
## 100 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 101 1.668304e+03 4.329646e+03 3.665077e+03 2.582297e+03
## 102 5.767470e+01 8.646360e+05 6.405424e+05 2.882448e+05
## 103 1.326042e+05 3.710591e+03 2.694644e+05 2.719622e+05
## 104 7.427755e+05 8.646360e+05 9.085539e+05 7.605760e+05
## 105 9.688184e+05 8.646360e+05 7.002796e+05 8.376754e+05
## 106 8.106922e+04 8.646360e+05 7.805817e+05 3.761836e+05
## 107 4.607584e+02 4.032228e+02 3.537759e+02 3.793166e+02
## 108 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 109 2.877919e+05 8.646360e+05 2.146030e+05 5.225637e+05
## 110 6.166136e+00 8.646360e+05 6.405315e+05 5.147380e+05
## 111 9.033835e+01 1.896944e+02 1.467386e+02 1.202735e+02
## 112 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 113 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 114 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 115 2.913874e+01 2.599988e+01 2.216636e+01 2.353251e+01
## 116 3.158778e+00 1.503926e+00 2.714397e+00 2.390657e+00
## 117 7.378269e+03 1.339617e+04 1.052029e+04 1.037344e+04
## 118 1.129264e+03 4.012633e+03 3.749191e+03 1.936071e+03
## 119 3.748306e+01 1.482546e+02 1.364821e+02 8.594322e+01
## 120 1.657042e+02 8.646360e+05 9.085539e+05 5.147912e+05
## 121 8.044455e-01 5.655809e+00 4.895831e+00 2.344056e+00
## 122 1.064652e+03 3.282232e+02 7.789105e+02 7.646217e+02
## 123 4.043035e+01 4.234833e+01 5.083629e+01 4.083081e+01
## 124 2.254192e+02 6.279184e+02 1.247859e+03 3.483973e+02
## 125 8.456370e+01 2.098091e+02 1.616987e+02 1.105014e+02
## 126 1.618111e+02 8.191781e+02 6.445424e+02 3.812935e+02
## 127 5.182005e+02 6.683840e+02 5.913789e+02 5.037617e+02
## 128 3.375756e+02 2.064764e+02 2.754643e+02 2.682639e+02
## 129 9.620491e+02 1.328757e+02 4.872801e+02 5.805586e+02
## 130 2.696758e+05 4.961997e+04 5.864172e+04 1.374303e+05
## 131 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 132 9.688184e+05 8.646360e+05 9.085539e+05 7.537504e+05
## 133 1.162036e+04 1.024197e+05 2.573156e+05 3.944315e+04
## 134 7.644206e+00 1.590779e+00 2.687438e+00 4.722777e+00
## 135 1.792104e+04 3.637757e+03 4.727920e+03 8.225571e+03
## 136 9.391206e+02 2.078550e+02 3.567306e+03 5.612741e+02
## 137 6.005075e+03 2.574016e+04 2.042148e+04 1.105715e+04
## 138 2.213955e+05 3.252824e+05 3.522475e+05 1.970681e+05
## 139 6.311935e+03 4.052446e+05 3.992767e+04 1.378286e+05
## 140 1.135150e+03 8.646360e+05 3.980802e+05 2.887211e+05
## 141 2.541427e+01 3.116514e+00 1.458470e+01 1.749366e+01
## 142 2.107070e+01 2.310981e+01 2.578527e+01 2.145449e+01
## 143 1.425174e+01 2.528541e+01 1.963673e+01 1.816789e+01
## 144 1.334814e+01 8.646360e+05 6.405316e+05 2.882181e+05
## 145 9.658681e+05 4.153400e+05 1.658888e+05 5.225156e+05
## 146 5.565605e+01 5.240503e+01 4.983733e+01 4.949901e+01
## 147 1.243996e+03 2.677378e+04 2.492875e+04 9.560229e+03
## 148 5.574763e+02 1.223530e+03 8.763779e+02 7.651496e+02
## 149 4.406345e+03 6.460514e+03 4.775415e+03 3.980408e+03
## 150 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 151 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 152 3.138577e+02 8.225921e+02 9.244979e+02 4.498145e+02
## 153 1.328460e+04 2.616962e+05 9.672769e+04 9.498979e+04
## 154 2.296095e+03 1.297128e+04 1.439275e+04 5.734684e+03
## 155 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 156 4.033797e+01 4.161712e+02 2.197233e+02 1.612548e+02
## 157 1.074396e+05 2.043855e+05 1.252208e+05 1.277505e+05
## 158 6.196315e+02 8.322847e+02 5.971010e+02 5.970211e+02
## 159 7.638463e+03 8.137135e+04 1.503210e+05 3.038767e+04
## 160 9.688184e+05 8.646360e+05 6.316401e+05 8.376754e+05
## 161 1.085818e+03 8.188942e+02 9.229954e+02 9.717171e+02
## 162 2.871711e+02 3.645653e+02 3.412461e+02 2.790184e+02
## 163 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 164 1.913156e+04 8.646360e+05 5.879021e+05 2.980828e+05
## 165 1.477758e+02 8.082363e+02 4.819231e+02 3.982491e+02
## 166 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 167 7.973485e+02 3.354917e+02 4.116191e+02 5.524065e+02
## 168 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 169 2.344874e+02 1.036757e+02 9.562846e+01 1.501713e+02
## 170 1.486948e+04 6.899161e+04 1.537968e+04 2.960250e+04
## 171 1.537283e+03 2.528443e+03 3.086806e+03 1.966782e+03
## 172 4.987381e+03 3.379123e+03 2.809895e+03 3.648067e+03
## 173 1.065423e+05 5.264589e+04 3.375079e+04 5.944168e+04
## 174 5.893621e+04 8.646360e+05 6.499757e+05 3.147882e+05
## 175 7.920758e+01 4.088232e+02 2.865723e+02 1.900864e+02
## 176 5.807183e+01 5.411413e+01 9.960450e+01 4.798439e+01
## 177 5.868754e+04 5.110601e+05 6.929342e+05 1.980558e+05
## 178 1.191044e+05 8.646360e+05 1.255955e+05 3.430128e+05
## 179 2.402457e+02 6.664280e+03 5.101751e+03 2.329023e+03
## 180 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 181 9.688184e+05 4.663849e+04 5.411819e+04 3.717411e+05
## 182 9.688184e+05 8.646360e+05 7.518073e+05 6.426501e+05
## 183 1.053296e+02 3.187614e+02 3.116307e+02 3.516635e+02
## 184 3.694180e+04 2.545274e+04 1.600451e+05 6.185699e+04
## 185 1.169272e+02 1.342618e+03 9.262512e+02 5.044650e+02
## 186 1.147274e+02 4.970549e+01 4.170609e+01 8.153016e+01
## 187 4.318525e+01 8.287156e+02 5.694510e+02 3.034073e+02
## 188 2.010779e+04 8.646360e+05 6.454529e+05 5.214386e+05
## 189 3.125429e+04 8.646360e+05 6.447818e+05 3.017531e+05
## 190 8.563225e+04 2.060069e+05 4.773233e+05 1.040234e+05
## 191 5.807183e+01 1.026796e+03 1.111771e+03 3.811753e+02
## 192 4.228149e+05 8.646360e+05 6.497704e+05 4.357432e+05
## 193 9.688184e+05 8.646360e+05 5.711225e+05 8.376754e+05
## 194 7.414669e+03 2.161590e+05 4.780229e+04 7.616424e+04
## 195 1.820055e+03 7.852875e+04 6.697678e+04 2.709396e+04
## 196 2.072699e+02 2.553806e+03 1.926410e+03 9.474584e+02
## 197 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 198 1.745396e+04 1.376611e+04 1.368194e+04 1.544877e+04
## 199 6.869868e+03 5.395098e+03 5.439847e+03 5.833555e+03
## 200 9.123923e+04 2.627009e+04 3.858854e+04 5.096164e+04
## 201 1.292158e+03 4.178766e+02 6.942434e+02 9.506306e+02
## 202 1.497365e+05 1.169987e+05 7.075496e+05 1.393666e+05
## 203 3.572689e+02 5.904870e+01 9.402101e+01 1.921702e+02
## 204 3.688367e+03 9.027641e+03 7.104930e+03 4.676402e+03
## 205 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 206 7.658842e+05 1.346973e+04 1.586906e+05 4.771713e+05
## 207 1.146730e+05 6.725535e+03 1.339859e+05 5.530003e+04
## 208 4.758986e+04 3.717212e+04 3.944919e+04 4.214924e+04
## 209 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 210 9.688184e+05 8.646360e+05 6.411379e+05 8.376754e+05
## 211 2.520102e+03 3.202931e+05 6.410810e+05 1.080455e+05
## 212 2.558372e+05 8.646360e+05 7.262769e+05 4.114566e+05
## 213 4.546040e+02 8.202008e+02 6.165014e+02 5.152256e+02
## 214 3.490618e+03 2.738620e+03 2.497032e+03 2.514995e+03
## 215 9.030529e+02 4.100720e+02 6.337249e+02 6.550776e+02
## 216 1.877163e+04 5.326991e+04 8.482634e+04 3.776347e+04
## 217 1.159587e+02 4.662505e+01 4.014367e+01 6.489060e+01
## 218 1.833350e+03 2.636677e+04 1.396049e+04 9.585544e+03
## 219 1.172089e+03 8.646360e+05 6.407824e+05 2.887423e+05
## 220 5.049493e+01 1.872219e+03 1.683068e+03 6.673841e+02
## 221 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 222 9.096947e+03 8.646360e+05 3.150398e+05 2.921469e+05
## 223 6.094933e+02 1.776479e+04 1.324196e+04 6.234104e+03
## 224 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 225 8.303862e+03 1.285136e+04 1.551597e+04 1.046469e+04
## 226 2.573183e+04 8.646360e+05 6.654961e+05 3.014908e+05
## 227 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 228 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 229 1.868632e+03 1.033109e+05 8.439440e+04 3.543347e+04
## 230 2.409962e+02 2.669647e+03 2.298309e+03 1.021476e+03
## 231 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 232 8.036584e+03 8.058152e+03 6.432644e+03 7.123625e+03
## 233 3.520749e+03 2.224605e+03 1.929896e+03 2.579792e+03
## 234 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 235 2.217377e+04 2.771796e+04 5.323960e+04 2.050537e+04
## 236 2.325360e+04 1.483002e+04 1.202977e+04 1.948035e+04
## 237 4.239383e+04 2.659622e+04 2.755367e+04 2.960838e+04
## 238 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 239 3.423525e+03 1.163540e+04 3.508457e+05 6.087204e+03
## 240 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 241 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 242 2.636139e+05 2.128435e+05 7.409926e+05 3.853431e+05
## 243 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 244 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 245 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 246 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 247 1.132635e+03 3.127463e+05 6.408367e+05 1.047743e+05
## 248 8.988960e+04 3.323605e+03 7.959265e+04 8.172211e+04
## 249 9.688184e+05 8.646360e+05 8.972433e+05 8.376754e+05
## 250 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 251 5.911444e+02 7.896849e+02 8.309786e+02 8.771032e+02
## 252 9.688184e+05 7.156692e+05 9.085539e+05 7.880198e+05
## 253 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 254 9.688184e+05 8.111794e+04 3.681760e+05 5.765027e+05
## 255 2.430118e+05 6.476656e+03 1.724755e+05 2.524255e+05
## 256 9.484858e+05 5.232937e+04 9.085539e+05 5.601290e+05
## 257 1.954303e+04 6.144728e+03 4.668737e+04 2.150935e+04
## 258 9.688184e+05 8.144471e+04 3.172831e+05 3.974255e+05
## 259 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 260 2.075390e+03 1.119474e+04 2.774197e+05 2.309473e+05
## 261 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 262 9.688184e+05 5.111763e+04 5.943714e+05 5.665026e+05
## 263 1.277602e+01 8.646360e+05 3.470703e+05 5.147402e+05
## 264 9.688184e+05 4.297867e+04 2.923189e+05 5.637896e+05
## 265 5.688524e+04 2.938787e+04 2.918768e+05 2.552817e+05
## 266 1.040968e+05 1.190792e+04 9.431164e+04 9.529139e+04
## 267 9.688184e+05 8.646360e+05 5.142920e+05 8.376754e+05
## 268 2.274779e+05 1.584602e+04 2.826358e+05 3.076319e+05
## 269 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 270 9.688184e+05 8.646360e+05 5.931722e+05 8.376754e+05
## 271 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 272 9.688184e+05 5.184558e+04 4.123783e+05 5.340744e+05
## 273 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 274 3.672805e+03 8.646360e+05 9.085539e+05 5.159602e+05
## 275 9.688184e+05 1.139652e+05 9.085539e+05 5.874518e+05
## 276 9.688184e+05 2.369563e+04 2.776257e+05 5.573620e+05
## 277 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 278 1.142367e+05 4.241930e+04 3.036752e+05 8.319125e+04
## 279 2.682932e+02 2.368460e+03 4.129131e+03 1.300978e+03
## 280 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 281 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 282 9.688184e+05 2.953024e+05 3.684376e+05 6.478975e+05
## 283 9.688184e+05 2.364595e+05 6.340625e+05 6.282832e+05
## 284 4.171917e+02 3.843917e+02 3.634281e+02 3.763169e+02
## 285 1.921299e+03 1.862124e+03 2.751672e+03 2.114261e+03
## 286 1.002089e+02 5.216742e+03 4.039143e+03 1.818542e+03
## 287 1.828365e+04 8.646360e+05 6.472756e+05 3.008744e+05
## 288 1.264727e+05 1.968904e+05 2.100243e+05 1.403746e+05
## 289 2.582962e+05 4.192157e+05 4.892737e+05 3.153934e+05
## 290 9.688184e+05 8.646360e+05 7.698423e+05 8.319244e+05
## 291 9.688184e+05 5.509773e+05 7.879937e+05 6.179611e+05
## 292 9.688184e+05 8.646360e+05 6.181908e+05 8.376754e+05
## 293 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 294 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 295 1.360396e+05 5.554361e+04 1.403139e+05 1.213902e+05
## 296 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 297 7.977442e+05 3.608234e+05 2.784017e+05 6.127132e+05
## 298 9.688184e+05 3.015282e+05 1.087875e+05 6.499728e+05
## 299 9.688184e+05 1.806870e+05 1.032479e+05 5.285016e+05
## 300 4.311095e+04 1.837689e+05 1.103235e+05 8.955273e+04
## 301 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 302 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 303 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 304 9.688184e+05 8.646360e+05 4.208153e+05 8.376754e+05
## 305 1.260624e+01 1.602225e+02 1.445647e+02 6.400663e+01
## 306 2.964224e+04 1.880115e+04 1.723048e+04 2.195692e+04
## 307 9.688184e+05 2.691333e+04 6.467359e+05 5.584345e+05
## 308 2.017899e+04 1.587791e+04 1.344902e+04 1.547046e+04
## 309 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 310 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 311 1.531403e+04 2.061926e+05 5.040817e+04 9.714625e+04
## 312 4.138713e+03 3.430639e+02 1.381962e+03 1.936386e+03
## 313 7.236310e+04 3.924805e+04 4.116892e+04 4.448413e+04
## 314 9.482783e+02 6.056772e+03 5.269991e+03 2.724956e+03
## 315 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 316 2.113090e+04 1.544694e+04 2.051180e+04 4.052774e+04
## 317 1.070774e+04 8.260042e+03 8.782006e+03 9.838070e+03
## 318 9.688184e+05 8.646360e+05 3.103641e+05 8.376754e+05
## 319 5.800006e+04 6.736733e+03 1.612418e+04 5.110505e+04
## 320 3.703081e+05 8.646360e+05 4.787417e+05 4.527211e+05
## 321 1.127934e+03 1.306060e+04 1.039059e+04 5.587493e+03
## 322 9.371333e+04 2.649685e+04 4.418969e+04 6.099164e+04
## 323 2.808606e+04 1.094537e+04 1.487667e+04 2.236082e+04
## 324 1.126740e+04 9.217970e+03 1.126373e+04 1.031554e+04
## 325 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 326 5.487627e+03 1.573469e+03 2.197843e+03 4.069901e+03
## 327 5.267528e+05 8.646360e+05 9.085539e+05 6.903202e+05
## 328 5.038906e+02 8.646360e+05 2.968195e+05 2.886498e+05
## 329 5.099594e+03 5.967890e+04 1.195490e+05 2.401554e+04
## 330 7.172671e+02 1.304431e+04 9.597224e+03 4.804909e+03
## 331 6.909640e+02 1.351957e+03 1.066661e+03 8.443102e+02
## 332 2.413760e+03 7.294844e+02 1.365497e+03 1.833323e+03
## 333 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 334 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 335 2.658997e+03 4.167485e+02 1.333000e+03 1.455312e+03
## 336 2.284867e+02 1.337509e+03 1.211781e+03 5.942276e+02
## 337 3.040656e+03 8.802108e+03 1.695463e+04 4.705929e+03
## 338 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 339 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 340 9.688184e+05 3.338715e+05 9.085539e+05 6.607539e+05
## 341 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 342 9.688184e+05 8.646360e+05 4.289292e+05 8.376754e+05
## 343 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 344 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 345 6.393271e+04 4.252529e+04 6.287904e+04 5.833279e+04
## 346 1.807859e+03 3.263177e+02 4.979292e+02 9.263046e+02
## 347 2.781537e+03 3.069171e+03 3.465179e+03 3.222431e+03
## 348 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 349 3.731011e+00 2.025398e+01 8.728410e+00 1.410767e+01
## 350 1.843417e+03 7.930000e+04 1.498276e+04 2.747327e+04
## 351 3.253026e+03 3.989415e+02 1.284191e+03 1.710206e+03
## 352 9.688184e+05 1.062154e+05 3.138240e+05 5.848685e+05
## 353 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 354 9.688184e+05 8.646360e+05 9.085539e+05 8.376754e+05
## 355 1.338720e+04 2.570778e+01 1.303380e+04 1.270683e+04
## 356 8.592694e+02 5.115961e+01 1.320710e+02 4.107687e+02
## 357 2.299395e+04 1.639883e+05 6.675153e+05 7.054560e+04
## 358 9.688184e+05 8.646360e+05 9.085539e+05 7.053491e+05
## 359 2.153624e+00 1.595527e+00 2.502476e+00 1.820180e+00
## 360 2.980261e+01 2.624250e+01 2.700550e+01 3.184368e+01

#Definir prueba estadistica: t-Student

tvalue_gen <- row_t_welch(promedio_genes[,c("DCT_C1",
                                            "DCT_C2",
                                            "DCT_C3"),],
                          promedio_genes[,c("DCT_T1",
                                            "DCT_T2",
                                            "DCT_T3")])
#View(tvalue_gen)
FCyPV <- promedio_genes %>% 
  select(1,8,9) %>% 
  mutate(p_value=tvalue_gen$pvalue,
         Fold_change = Mean_DCT_Tx / Mean_DCT_Cx) %>% 
  select(1,4,5)

FCyPV  
##                         Gen    p_value Fold_change
## 1        ath-miR159a-000338 0.55463228  0.92198758
## 2         hsa-let-7a-000377 0.22436618  0.65488457
## 3         hsa-let-7b-002619 0.24079791  0.62104704
## 4         hsa-let-7c-000379 0.64364598  0.77544807
## 5         hsa-let-7d-002283 0.23887834  0.60711339
## 6         hsa-let-7e-002406 0.37995390  0.75749148
## 7         hsa-let-7f-000382 0.25894560  0.56446606
## 8         hsa-let-7g-002282 0.95470420  1.01333324
## 9          hsa-miR-1-002222 0.62056699  1.29392830
## 10       hsa-miR-100-000437 0.90182914  0.96295949
## 11       hsa-miR-101-002253 0.34373848  0.58129183
## 12       hsa-miR-103-000439 0.42760203  0.55783620
## 13       hsa-miR-105-002167 0.51295353  2.00941179
## 14      hsa-miR-106a-002169 0.49068503  1.89078080
## 15      hsa-miR-106b-000442 0.48357214  1.43676082
## 16       hsa-miR-107-000443 0.41278599  0.56950720
## 17       hsa-miR-10a-000387 0.38665368  0.67415147
## 18       hsa-miR-10b-002218 0.51344460  2.04957173
## 19       hsa-miR-122-002245 0.91989321  1.12857966
## 20   hsa-miR-125a-3p-002199 0.30138614  1.38296614
## 21   hsa-miR-125a-5p-002198 0.81723778  1.14147018
## 22      hsa-miR-125b-000449 0.42651115  1.17338758
## 23       hsa-miR-126-002228 0.64605931  0.61099754
## 24       hsa-miR-127-000452 0.38860511  0.41288465
## 25    hsa-miR-127-5p-002229 0.24501762  0.46839423
## 26      hsa-miR-128a-002216 0.86287303  0.90643177
## 27       hsa-miR-129-000590 0.15822229  3.06670239
## 28      hsa-miR-130a-000454 0.32926421  0.43114344
## 29      hsa-miR-130b-000456 0.61769066  1.18385753
## 30       hsa-miR-132-000457 0.23182162  0.59221843
## 31      hsa-miR-133a-002246 0.62737714  0.87900931
## 32      hsa-miR-133b-002247 0.64472739  0.75401027
## 33      hsa-miR-135a-000460 0.65891210  0.76720044
## 34      hsa-miR-135b-002261 0.39797410 19.17158519
## 35       hsa-miR-136-000592 0.55463228  0.92198758
## 36       hsa-miR-138-002284 0.43851638  3.30756623
## 37    hsa-miR-139-3p-002313 0.15841422  3.10907979
## 38    hsa-miR-139-5p-002289 0.65220487  1.23059529
## 39    hsa-miR-140-3p-002234 0.92481245  0.93905371
## 40       hsa-miR-141-000463 0.90111237  1.08345565
## 41    hsa-miR-142-3p-000464 0.34550568  2.47194868
## 42    hsa-miR-142-5p-002248 0.55463228  0.92198758
## 43       hsa-miR-143-002249 0.30753757  0.30069778
## 44       hsa-miR-145-002278 0.26615671  0.23566339
## 45      hsa-miR-146a-000468 0.61055553  0.62851188
## 46      hsa-miR-146b-001097 0.20665911  1.18963311
## 47   hsa-miR-146b-3p-002361 0.78056135  0.81079204
## 48       hsa-miR-147-000469 0.55463228  0.92198758
## 49      hsa-miR-147b-002262 0.55463228  0.92198758
## 50      hsa-miR-148a-000470 0.20665233  0.10181243
## 51      hsa-miR-148b-000471 0.90363803  0.90616130
## 52       hsa-miR-149-002255 0.67861330  0.72962055
## 53       hsa-miR-150-000473 0.93789414  1.03452752
## 54       hsa-miR-152-000475 0.44418730  0.57148236
## 55       hsa-miR-154-000477 0.45381566  0.46001978
## 56       hsa-miR-155-002623 0.32742806  2.64848449
## 57       hsa-miR-15a-000389 0.95049486  0.95408991
## 58       hsa-miR-15b-000390 0.40010731  1.74481635
## 59        hsa-miR-16-000391 0.39310638  1.29834956
## 60        hsa-miR-17-002308 0.46745534  2.10060849
## 61      hsa-miR-181a-000480 0.31469078  0.66680523
## 62      hsa-miR-181c-000482 0.34707354  0.42226689
## 63       hsa-miR-182-002334 0.53620402  2.40502487
## 64       hsa-miR-183-002269 0.94667579  0.92593126
## 65       hsa-miR-184-000485 0.52467260  0.69831851
## 66       hsa-miR-185-002271 0.94576177  0.96916363
## 67       hsa-miR-186-002285 0.14867278  0.32052133
## 68    hsa-miR-188-3p-002106 0.55463228  0.92198758
## 69       hsa-miR-18a-002422 0.39862200  3.52624382
## 70       hsa-miR-18b-002217 0.39659134  3.10858764
## 71       hsa-miR-190-000489 0.27999412  0.28607816
## 72       hsa-miR-191-002299 0.80011280  1.17100153
## 73       hsa-miR-192-000491 0.54397206  0.76633406
## 74   hsa-miR-193a-3p-002250 0.47614914  1.56839367
## 75   hsa-miR-193a-5p-002281 0.35680144  0.59267845
## 76      hsa-miR-193b-002367 0.49060335  0.70453424
## 77       hsa-miR-194-000493 0.78461554  1.07523331
## 78       hsa-miR-195-000494 0.58821337  0.71638934
## 79      hsa-miR-196b-002215 0.61580257  0.73744433
## 80       hsa-miR-197-000497 0.31718585  0.85730045
## 81       hsa-miR-198-002273 0.44271602  0.49403162
## 82      hsa-miR-199a-000498 0.46302950  0.45643283
## 83   hsa-miR-199a-3p-002304 0.36416950  0.35901188
## 84      hsa-miR-199b-000500 0.83259000  0.78206029
## 85       hsa-miR-19a-000395 0.42772764  1.72001521
## 86       hsa-miR-19b-000396 0.39877551  2.50546855
## 87      hsa-miR-200a-000502 0.55463228  0.92198758
## 88      hsa-miR-200b-002251 0.77594191  1.10633183
## 89      hsa-miR-200c-002300 0.64953922  1.36564055
## 90       hsa-miR-202-002363 0.24834522  0.61507324
## 91       hsa-miR-203-000507 0.74327189  1.47932423
## 92       hsa-miR-204-000508 0.88811742  1.13245588
## 93       hsa-miR-205-000509 0.55463228  0.92198758
## 94       hsa-miR-208-000511 0.55463228  0.92198758
## 95      hsa-miR-208b-002290 0.43838701  0.70191417
## 96       hsa-miR-20a-000580 0.45521101  2.16082946
## 97       hsa-miR-20b-001014 0.46539391  1.97322331
## 98        hsa-miR-21-000397 0.77308965  1.07501653
## 99       hsa-miR-210-000512 0.83829834  1.20826124
## 100      hsa-miR-211-000514 0.55463228  0.92198758
## 101      hsa-miR-212-000515 0.42429916  0.70456838
## 102      hsa-miR-214-002306 0.46240192  0.45000111
## 103      hsa-miR-215-000518 0.99448160  1.00926948
## 104     hsa-miR-216a-002220 0.17654015  0.83712814
## 105     hsa-miR-216b-002326 0.62427196  1.19620141
## 106      hsa-miR-217-002337 0.26481904  0.48192726
## 107      hsa-miR-218-000521 0.71959745  1.07219456
## 108      hsa-miR-219-000522 0.55463228  0.92198758
## 109 hsa-miR-219-1-3p-002095 0.21354251  2.43502512
## 110 hsa-miR-219-2-3p-002390 0.77849497  0.80361082
## 111       hsa-miR-22-000398 0.64638250  0.81964495
## 112      hsa-miR-220-000523 0.55463228  0.92198758
## 113     hsa-miR-220b-002206 0.55463228  0.92198758
## 114     hsa-miR-220c-002211 0.55463228  0.92198758
## 115      hsa-miR-221-000524 0.80140873  1.06163177
## 116      hsa-miR-222-002276 0.76554865  0.88073235
## 117      hsa-miR-223-002295 0.94681578  0.98604086
## 118      hsa-miR-224-002099 0.44760710  0.51639712
## 119      hsa-miR-23a-000399 0.39067969  0.62970317
## 120      hsa-miR-23b-000400 0.26987232  0.56660501
## 121       hsa-miR-24-000402 0.40483713  0.47878606
## 122       hsa-miR-25-000403 0.97862495  0.98165539
## 123      hsa-miR-26a-000405 0.22736388  0.80318237
## 124      hsa-miR-26b-000407 0.16916292  0.27919614
## 125      hsa-miR-27a-000408 0.55471249  0.68337840
## 126      hsa-miR-27b-000409 0.47574344  0.59157242
## 127       hsa-miR-28-000411 0.58038237  0.85184258
## 128    hsa-miR-28-3p-002446 0.91592958  0.97386092
## 129      hsa-miR-296-000527 0.82636517  1.19142680
## 130   hsa-miR-296-3p-002101 0.36802403  2.34355830
## 131      hsa-miR-298-002190 0.55463228  0.92198758
## 132   hsa-miR-299-3p-001015 0.45927808  0.82961554
## 133   hsa-miR-299-5p-000600 0.22857748  0.15328706
## 134      hsa-miR-29a-002112 0.40935737  1.75735321
## 135      hsa-miR-29b-000413 0.54627089  1.73978639
## 136      hsa-miR-29c-000587 0.37272411  0.15733839
## 137      hsa-miR-301-000528 0.48379069  0.54144680
## 138     hsa-miR-301b-002392 0.42078514  0.55945902
## 139     hsa-miR-302a-000529 0.54136315  3.45195682
## 140     hsa-miR-302b-000531 0.81354605  0.72528364
## 141     hsa-miR-302c-000533 0.78077856  1.19945339
## 142      hsa-miR-30b-000602 0.05273105  0.83204450
## 143      hsa-miR-30c-000419 0.74872297  0.92519930
## 144       hsa-miR-31-002279 0.46239929  0.44996708
## 145       hsa-miR-32-002109 0.26180868  3.14979321
## 146      hsa-miR-320-002277 0.94841083  0.99321156
## 147   hsa-miR-323-3p-002227 0.43022215  0.38350209
## 148   hsa-miR-324-3p-002161 0.72072614  0.87308171
## 149   hsa-miR-324-5p-000539 0.74850901  0.83352086
## 150      hsa-miR-325-000540 0.55463228  0.92198758
## 151      hsa-miR-326-000542 0.55463228  0.92198758
## 152      hsa-miR-328-000543 0.29250959  0.48655003
## 153      hsa-miR-329-001101 0.98656374  0.98203307
## 154      hsa-miR-330-000544 0.31048924  0.39844242
## 155   hsa-miR-330-5p-002230 0.55463228  0.92198758
## 156      hsa-miR-331-000545 0.73368316  0.73389949
## 157   hsa-miR-331-5p-002233 0.96831080  1.02020140
## 158      hsa-miR-335-000546 0.99962938  0.99986617
## 159   hsa-miR-337-5p-002156 0.24301323  0.20215185
## 160   hsa-miR-338-3p-002252 0.44139567  1.32619088
## 161   hsa-miR-339-3p-002184 0.62787846  1.05278659
## 162   hsa-miR-339-5p-002257 0.45756372  0.81764571
## 163      hsa-miR-33b-002085 0.55463228  0.92198758
## 164      hsa-miR-340-002258 0.51380264  0.50702797
## 165   hsa-miR-342-3p-002260 0.77390879  0.82637478
## 166   hsa-miR-342-5p-002147 0.55463228  0.92198758
## 167      hsa-miR-345-002186 0.41344580  1.34203317
## 168      hsa-miR-346-000553 0.55463228  0.92198758
## 169      hsa-miR-34a-000426 0.32472296  1.57036191
## 170      hsa-miR-34c-000428 0.55580025  1.92477945
## 171      hsa-miR-361-000554 0.04778069  0.63715778
## 172      hsa-miR-362-001273 0.35876927  1.29829300
## 173   hsa-miR-362-3p-002117 0.42102485  1.76119365
## 174      hsa-miR-363-001271 0.46798294  0.48430761
## 175      hsa-miR-365-001020 0.57795991  0.66331046
## 176      hsa-miR-367-000555 0.12481473  0.48174924
## 177   hsa-miR-369-3p-000557 0.20733217  0.28582199
## 178   hsa-miR-369-5p-001021 0.49623054  2.73109239
## 179      hsa-miR-370-002275 0.45702571  0.45651438
## 180   hsa-miR-371-3p-002124 0.55463228  0.92198758
## 181      hsa-miR-372-000560 0.39932585  6.86906009
## 182      hsa-miR-373-000561 0.77103794  0.85480704
## 183      hsa-miR-374-000563 0.84013745  1.12846261
## 184      hsa-miR-375-000564 0.49601234  0.38649732
## 185     hsa-miR-376a-000565 0.52246258  0.54463090
## 186     hsa-miR-376b-001102 0.15608057  1.95487405
## 187     hsa-miR-376c-002122 0.52379231  0.53280674
## 188      hsa-miR-377-000566 0.77750365  0.80786461
## 189   hsa-miR-380-3p-000569 0.46625407  0.46799249
## 190      hsa-miR-381-000571 0.29995816  0.21793064
## 191      hsa-miR-382-000572 0.34583501  0.34285401
## 192      hsa-miR-383-000573 0.62093939  0.67061104
## 193      hsa-miR-384-000574 0.43421576  1.46671764
## 194   hsa-miR-409-5p-002331 0.73229105  1.59331777
## 195      hsa-miR-410-001274 0.39691293  0.40452775
## 196      hsa-miR-411-001610 0.47711091  0.49182582
## 197      hsa-miR-412-001023 0.55463228  0.92198758
## 198     hsa-miR-422a-002297 0.45758632  1.12913599
## 199   hsa-miR-423-5p-002340 0.56139550  1.07237485
## 200      hsa-miR-424-000604 0.63008429  1.32064167
## 201   hsa-miR-425-5p-001516 0.56679600  1.36930457
## 202      hsa-miR-429-001024 0.15779879  0.19697072
## 203      hsa-miR-431-001979 0.38950331  2.04390693
## 204      hsa-miR-433-001028 0.60740124  0.65819111
## 205      hsa-miR-448-001029 0.55463228  0.92198758
## 206      hsa-miR-449-001030 0.32610688  3.00692854
## 207     hsa-miR-449b-001608 0.60802320  0.41273022
## 208     hsa-miR-450a-002303 0.77934362  1.06844378
## 209  hsa-miR-450b-3p-002208 0.55463228  0.92198758
## 210  hsa-miR-450b-5p-002207 0.60936094  1.30654474
## 211      hsa-miR-452-002329 0.23562867  0.16853645
## 212      hsa-miR-453-002318 0.39666980  0.56652857
## 213      hsa-miR-454-002323 0.63619378  0.83572494
## 214      hsa-miR-455-001280 0.98428304  1.00719353
## 215   hsa-miR-455-3p-002244 0.90903970  1.03369391
## 216   hsa-miR-483-5p-002338 0.09229146  0.44518567
## 217      hsa-miR-484-001821 0.43997269  1.61645912
## 218   hsa-miR-485-3p-001277 0.70646451  0.68661949
## 219   hsa-miR-485-5p-001036 0.46237827  0.45060904
## 220      hsa-miR-486-001278 0.40020668  0.39652818
## 221   hsa-miR-486-3p-002093 0.55463228  0.92198758
## 222     hsa-miR-487a-001279 0.95738679  0.92733353
## 223     hsa-miR-487b-001285 0.47254594  0.47078428
## 224      hsa-miR-488-002357 0.55463228  0.92198758
## 225      hsa-miR-489-002358 0.04150317  0.67444658
## 226      hsa-miR-490-001037 0.42566017  0.45303161
## 227   hsa-miR-491-3p-002360 0.55463228  0.92198758
## 228      hsa-miR-492-001039 0.55463228  0.92198758
## 229      hsa-miR-493-002364 0.43634873  0.41985567
## 230      hsa-miR-494-002365 0.40280130  0.44444684
## 231   hsa-miR-499-3p-002427 0.55463228  0.92198758
## 232      hsa-miR-500-002428 0.53526933  1.10741785
## 233      hsa-miR-501-001047 0.36763575  1.33675205
## 234   hsa-miR-501-3p-002435 0.55463228  0.92198758
## 235      hsa-miR-502-001109 0.18630448  0.38515262
## 236   hsa-miR-502-3p-002083 0.08227632  1.61934488
## 237      hsa-miR-503-001048 0.79082915  1.07457110
## 238      hsa-miR-504-002084 0.55463228  0.92198758
## 239      hsa-miR-505-002089 0.42311286  0.01735009
## 240      hsa-miR-506-001050 0.55463228  0.92198758
## 241      hsa-miR-507-001051 0.55463228  0.92198758
## 242      hsa-miR-508-001052 0.26667296  0.52003635
## 243   hsa-miR-508-5p-002092 0.55463228  0.92198758
## 244 hsa-miR-509-3-5p-002155 0.55463228  0.92198758
## 245   hsa-miR-509-5p-002235 0.55463228  0.92198758
## 246      hsa-miR-510-002241 0.55463228  0.92198758
## 247      hsa-miR-511-001111 0.23402542  0.16349608
## 248   hsa-miR-512-3p-001823 0.98199781  1.02675447
## 249   hsa-miR-512-5p-001145 0.59835436  0.93361014
## 250   hsa-miR-513-5p-002090 0.55463228  0.92198758
## 251   hsa-miR-515-3p-002369 0.84991121  1.05550632
## 252   hsa-miR-515-5p-001112 0.35639217  0.86733414
## 253  hsa-miR-516a-5p-002416 0.55463228  0.92198758
## 254     hsa-miR-516b-001150 0.57662573  1.56583467
## 255     hsa-miR-517a-002402 0.73497674  1.46354415
## 256     hsa-miR-517b-001152 0.31870492  0.61650611
## 257     hsa-miR-517c-001153 0.58372267  0.46071035
## 258  hsa-miR-518a-3p-002397 0.84183339  1.25258953
## 259  hsa-miR-518a-5p-002396 0.55463228  0.92198758
## 260     hsa-miR-518b-001156 0.89977690  0.83248371
## 261     hsa-miR-518c-002401 0.55463228  0.92198758
## 262     hsa-miR-518d-001159 0.94326894  0.95311225
## 263  hsa-miR-518d-5p-002389 0.72110602  1.48310062
## 264     hsa-miR-518e-002395 0.50884078  1.92868033
## 265     hsa-miR-518f-002388 0.91788352  0.87462134
## 266     hsa-miR-519a-002415 0.99227054  1.01038840
## 267     hsa-miR-519c-001163 0.17858795  1.62879329
## 268     hsa-miR-519d-002403 0.94283959  1.08843925
## 269     hsa-miR-519e-002370 0.55463228  0.92198758
## 270    hsa-miR-520a#-001168 0.43616196  1.41219604
## 271     hsa-miR-520a-001167 0.55463228  0.92198758
## 272     hsa-miR-520b-001116 0.73291145  1.29510791
## 273  hsa-miR-520d-5p-002393 0.55463228  0.92198758
## 274     hsa-miR-520e-001119 0.26936554  0.56789171
## 275     hsa-miR-520f-001120 0.32855711  0.64657893
## 276     hsa-miR-520g-001121 0.50682515  2.00760187
## 277      hsa-miR-521-001122 0.55463228  0.92198758
## 278      hsa-miR-522-002413 0.47140277  0.27394816
## 279      hsa-miR-523-002386 0.38465514  0.31507300
## 280   hsa-miR-524-5p-001982 0.55463228  0.92198758
## 281      hsa-miR-525-001174 0.55463228  0.92198758
## 282   hsa-miR-525-3p-002385 0.39702201  1.75850025
## 283     hsa-miR-526b-002382 0.98820249  0.99088537
## 284      hsa-miR-532-001518 0.76660814  1.03546442
## 285   hsa-miR-532-3p-002355 0.21330445  0.76835494
## 286      hsa-miR-539-001286 0.44459156  0.45022972
## 287      hsa-miR-541-002201 0.46053591  0.46483199
## 288   hsa-miR-542-3p-001284 0.31429531  0.66837308
## 289   hsa-miR-542-5p-002240 0.59533048  0.64461545
## 290      hsa-miR-544-002265 0.79383746  1.08064268
## 291      hsa-miR-545-002267 0.54634950  0.78422081
## 292     hsa-miR-548a-001538 0.47301354  1.35504356
## 293  hsa-miR-548a-5p-002412 0.55463228  0.92198758
## 294     hsa-miR-548b-001541 0.55463228  0.92198758
## 295  hsa-miR-548b-5p-002408 0.84828578  0.86513299
## 296     hsa-miR-548c-001590 0.55463228  0.92198758
## 297  hsa-miR-548c-5p-002429 0.10861144  2.20082410
## 298     hsa-miR-548d-001605 0.09911546  5.97470163
## 299  hsa-miR-548d-5p-002237 0.20727404  5.11876152
## 300     hsa-miR-551b-001535 0.75771921  0.81172880
## 301   hsa-miR-556-3p-002345 0.55463228  0.92198758
## 302   hsa-miR-556-5p-002344 0.55463228  0.92198758
## 303      hsa-miR-561-001528 0.55463228  0.92198758
## 304      hsa-miR-570-002347 0.14893711  1.99060135
## 305   hsa-miR-574-3p-002349 0.36742348  0.44275423
## 306   hsa-miR-576-3p-002351 0.36097446  1.27430674
## 307   hsa-miR-576-5p-002350 0.84477566  0.86346616
## 308      hsa-miR-579-002398 0.55481581  1.15030407
## 309   hsa-miR-582-3p-002399 0.55463228  0.92198758
## 310   hsa-miR-582-5p-001983 0.55463228  0.92198758
## 311      hsa-miR-589-002409 0.50010686  1.92719268
## 312   hsa-miR-590-5p-001984 0.71573114  1.40118621
## 313      hsa-miR-597-001551 0.85055291  1.08052702
## 314      hsa-miR-598-001988 0.39481575  0.51707030
## 315   hsa-miR-615-5p-002353 0.55463228  0.92198758
## 316      hsa-miR-616-002414 0.46562667  1.97582557
## 317      hsa-miR-618-001593 0.63662829  1.12025315
## 318      hsa-miR-624-002430 0.15704600  2.69900828
## 319      hsa-miR-625-002431 0.28121278  3.16946711
## 320      hsa-miR-627-001560 0.91677837  0.94564788
## 321   hsa-miR-628-5p-002433 0.40565675  0.53774543
## 322      hsa-miR-629-002436 0.52110754  1.38022330
## 323      hsa-miR-636-002088 0.34284273  1.50307971
## 324      hsa-miR-642-001592 0.55005520  0.91581897
## 325      hsa-miR-651-001604 0.55463228  0.92198758
## 326      hsa-miR-652-002352 0.27075779  1.85177044
## 327      hsa-miR-653-002292 0.15081258  0.75980109
## 328      hsa-miR-654-001611 0.98505617  0.97247570
## 329   hsa-miR-654-3p-002239 0.30934238  0.20088441
## 330      hsa-miR-655-001612 0.47271025  0.50065616
## 331      hsa-miR-660-001515 0.62978321  0.79154507
## 332   hsa-miR-671-3p-002322 0.60121828  1.34260483
## 333      hsa-miR-672-002327 0.55463228  0.92198758
## 334      hsa-miR-674-002021 0.55463228  0.92198758
## 335      hsa-miR-708-002341 0.90537539  1.09175643
## 336      hsa-miR-744-002324 0.36364963  0.49037554
## 337      hsa-miR-758-001990 0.24414353  0.27756008
## 338      hsa-miR-871-002354 0.55463228  0.92198758
## 339      hsa-miR-872-002264 0.55463228  0.92198758
## 340      hsa-miR-873-002356 0.30947326  0.72725891
## 341   hsa-miR-875-3p-002204 0.55463228  0.92198758
## 342   hsa-miR-876-3p-002225 0.15141071  1.95294576
## 343   hsa-miR-876-5p-002205 0.55463228  0.92198758
## 344   hsa-miR-885-3p-002372 0.55463228  0.92198758
## 345   hsa-miR-885-5p-002296 0.86727713  0.92769848
## 346   hsa-miR-886-3p-002194 0.44339224  1.86031390
## 347   hsa-miR-886-5p-002193 0.66883330  0.92994642
## 348      hsa-miR-887-002374 0.55463228  0.92198758
## 349      hsa-miR-888-002212 0.41137674  1.61629348
## 350      hsa-miR-889-002202 0.68318677  1.83365869
## 351      hsa-miR-890-002209 0.73296446  1.33173867
## 352     hsa-miR-891a-002191 0.48503362  1.86368347
## 353     hsa-miR-891b-002210 0.55463228  0.92198758
## 354     hsa-miR-892a-002195 0.55463228  0.92198758
## 355        hsa-miR-9-000583 0.98375776  0.97491358
## 356      hsa-miR-92a-000431 0.36525722  3.11021258
## 357       hsa-miR-95-000433 0.17937308  0.10568388
## 358       hsa-miR-98-000577 0.44645246  0.77634265
## 359      hsa-miR-99a-000435 0.28756199  0.72735149
## 360      hsa-miR-99b-000436 0.34626087  1.17915537
Logs <- FCyPV %>% 
  mutate(LPV = -log10(p_value),
         LFC = log2(Fold_change)) %>% 
select(1,4,5)

Logs
##                         Gen         LPV           LFC
## 1        ath-miR159a-000338 0.255994860 -0.1171807739
## 2         hsa-let-7a-000377 0.649042608 -0.6106874527
## 3         hsa-let-7b-002619 0.618347292 -0.6872255560
## 4         hsa-let-7c-000379 0.191352939 -0.3668979180
## 5         hsa-let-7d-002283 0.621823224 -0.7199621047
## 6         hsa-let-7e-002406 0.420269099 -0.4006984277
## 7         hsa-let-7f-000382 0.586791458 -0.8250412698
## 8         hsa-let-7g-002282 0.020131169  0.0191086964
## 9          hsa-miR-1-002222 0.207211332  0.3717576767
## 10       hsa-miR-100-000437 0.044875736 -0.0544529930
## 11       hsa-miR-101-002253 0.463771847 -0.7826654585
## 12       hsa-miR-103-000439 0.368960244 -0.8420865343
## 13       hsa-miR-105-002167 0.289921974  1.0067732439
## 14      hsa-miR-106a-002169 0.309197193  0.9189821230
## 15      hsa-miR-106b-000442 0.315538732  0.5228199162
## 16       hsa-miR-107-000443 0.384275053 -0.8122140191
## 17       hsa-miR-10a-000387 0.412677855 -0.5688553246
## 18       hsa-miR-10b-002218 0.289506413  1.0353224837
## 19       hsa-miR-122-002245 0.036262587  0.1745082504
## 20   hsa-miR-125a-3p-002199 0.520876717  0.4677658355
## 21   hsa-miR-125a-5p-002198 0.087651565  0.1908931768
## 22      hsa-miR-125b-000449 0.370069608  0.2306796246
## 23       hsa-miR-126-002228 0.189727609 -0.7107615128
## 24       hsa-miR-127-000452 0.410491487 -1.2761893206
## 25    hsa-miR-127-5p-002229 0.610802679 -1.0942047794
## 26      hsa-miR-128a-002216 0.064053106 -0.1417296724
## 27       hsa-miR-129-000590 0.800732326  1.6166881646
## 28      hsa-miR-130a-000454 0.482455477 -1.2137601627
## 29      hsa-miR-130b-000456 0.209228969  0.2434954737
## 30       hsa-miR-132-000457 0.634846060 -0.7557987083
## 31      hsa-miR-133a-002246 0.202471311 -0.1860496423
## 32      hsa-miR-133b-002247 0.190623876 -0.4073439303
## 33      hsa-miR-135a-000460 0.181172518 -0.3823245416
## 34      hsa-miR-135b-002261 0.400145193  4.2608977250
## 35       hsa-miR-136-000592 0.255994860 -0.1171807739
## 36       hsa-miR-138-002284 0.358014177  1.7257700465
## 37    hsa-miR-139-3p-002313 0.800205845  1.6364876439
## 38    hsa-miR-139-5p-002289 0.185615962  0.2993563732
## 39    hsa-miR-140-3p-002234 0.033946332 -0.0907204260
## 40       hsa-miR-141-000463 0.045221047  0.1156400989
## 41    hsa-miR-142-3p-000464 0.461544812  1.3056487911
## 42    hsa-miR-142-5p-002248 0.255994860 -0.1171807739
## 43       hsa-miR-143-002249 0.512101816 -1.7336138937
## 44       hsa-miR-145-002278 0.574862575 -2.0852004280
## 45      hsa-miR-146a-000468 0.214274834 -0.6699880873
## 46      hsa-miR-146b-001097 0.684745438  0.2505167107
## 47   hsa-miR-146b-3p-002361 0.107592958 -0.3025961768
## 48       hsa-miR-147-000469 0.255994860 -0.1171807739
## 49      hsa-miR-147b-002262 0.255994860 -0.1171807739
## 50      hsa-miR-148a-000470 0.684759683 -3.2960143322
## 51      hsa-miR-148b-000471 0.044005502 -0.1421602135
## 52       hsa-miR-149-002255 0.168377633 -0.4547817363
## 53       hsa-miR-150-000473 0.027846178  0.0489720175
## 54       hsa-miR-152-000475 0.352433859 -0.8072191325
## 55       hsa-miR-154-000477 0.343120517 -1.1202321944
## 56       hsa-miR-155-002623 0.484884102  1.4051670584
## 57       hsa-miR-15a-000389 0.022050229 -0.0678028747
## 58       hsa-miR-15b-000390 0.397823518  0.8030751976
## 59        hsa-miR-16-000391 0.405489907  0.3766788602
## 60        hsa-miR-17-002308 0.330259877  1.0708072999
## 61      hsa-miR-181a-000480 0.502115984 -0.5846626822
## 62      hsa-miR-181c-000482 0.459578489 -1.2437729690
## 63       hsa-miR-182-002334 0.270669938  1.2660518120
## 64       hsa-miR-183-002269 0.023798731 -0.1110230014
## 65       hsa-miR-184-000485 0.280111615 -0.5180428910
## 66       hsa-miR-185-002271 0.024218245 -0.0451878347
## 67       hsa-miR-186-002285 0.827768534 -1.6415077467
## 68    hsa-miR-188-3p-002106 0.255994860 -0.1171807739
## 69       hsa-miR-18a-002422 0.399438734  1.8181322323
## 70       hsa-miR-18b-002217 0.401656770  1.6362592524
## 71       hsa-miR-190-000489 0.552851083 -1.8055187421
## 72       hsa-miR-191-002299 0.096848781  0.2277429550
## 73       hsa-miR-192-000491 0.264423404 -0.3839546726
## 74   hsa-miR-193a-3p-002250 0.322256999  0.6492877259
## 75   hsa-miR-193a-5p-002281 0.447573403 -0.7546784874
## 76      hsa-miR-193b-002367 0.309269489 -0.5052582645
## 77       hsa-miR-194-000493 0.105343097  0.1046497342
## 78       hsa-miR-195-000494 0.230465108 -0.4811842344
## 79      hsa-miR-196b-002215 0.210558505 -0.4393939608
## 80       hsa-miR-197-000497 0.498686192 -0.2221271955
## 81       hsa-miR-198-002273 0.353874760 -1.0173247109
## 82      hsa-miR-199a-000498 0.334391343 -1.1315255456
## 83   hsa-miR-199a-3p-002304 0.438696434 -1.4778964924
## 84      hsa-miR-199b-000500 0.079568809 -0.3546482611
## 85       hsa-miR-19a-000395 0.368832679  0.7824213206
## 86       hsa-miR-19b-000396 0.399271519  1.3250804311
## 87      hsa-miR-200a-000502 0.255994860 -0.1171807739
## 88      hsa-miR-200b-002251 0.110170793  0.1457841679
## 89      hsa-miR-200c-002300 0.187394618  0.4495778065
## 90       hsa-miR-202-002363 0.604944197 -0.7011698790
## 91       hsa-miR-203-000507 0.128852294  0.5649382874
## 92       hsa-miR-204-000508 0.051529609  0.1794548412
## 93       hsa-miR-205-000509 0.255994860 -0.1171807739
## 94       hsa-miR-208-000511 0.255994860 -0.1171807739
## 95      hsa-miR-208b-002290 0.358142323 -0.5106334726
## 96       hsa-miR-20a-000580 0.341787246  1.1115852172
## 97       hsa-miR-20b-001014 0.332179300  0.9805542372
## 98        hsa-miR-21-000397 0.111770143  0.1043588401
## 99       hsa-miR-210-000512 0.076601391  0.2729324113
## 100      hsa-miR-211-000514 0.255994860 -0.1171807739
## 101      hsa-miR-212-000515 0.372327832 -0.5051883745
## 102      hsa-miR-214-002306 0.334980368 -1.1519995236
## 103      hsa-miR-215-000518 0.002403247  0.0133114284
## 104     hsa-miR-216a-002220 0.753156514 -0.2564796199
## 105     hsa-miR-216b-002326 0.204626174  0.2584603180
## 106      hsa-miR-217-002337 0.577050788 -1.0531126861
## 107      hsa-miR-218-000521 0.142910385  0.1005667201
## 108      hsa-miR-219-000522 0.255994860 -0.1171807739
## 109 hsa-miR-219-1-3p-002095 0.670515655  1.2839366558
## 110 hsa-miR-219-2-3p-002390 0.108744189 -0.3154310990
## 111       hsa-miR-22-000398 0.189510411 -0.2869289876
## 112      hsa-miR-220-000523 0.255994860 -0.1171807739
## 113     hsa-miR-220b-002206 0.255994860 -0.1171807739
## 114     hsa-miR-220c-002211 0.255994860 -0.1171807739
## 115      hsa-miR-221-000524 0.096145929  0.0862834558
## 116      hsa-miR-222-002276 0.116027205 -0.1832244444
## 117      hsa-miR-223-002295 0.023734513 -0.0202806685
## 118      hsa-miR-224-002099 0.349103030 -0.9534471388
## 119      hsa-miR-23a-000399 0.408179160 -0.6672561578
## 120      hsa-miR-23b-000400 0.568841652 -0.8195847251
## 121       hsa-miR-24-000402 0.392719659 -1.0625469523
## 122       hsa-miR-25-000403 0.009383718 -0.0267114393
## 123      hsa-miR-26a-000405 0.643278529 -0.3162004919
## 124      hsa-miR-26b-000407 0.771694836 -1.8406491230
## 125      hsa-miR-27a-000408 0.255932054 -0.5492434526
## 126      hsa-miR-27b-000409 0.322627189 -0.7573732958
## 127       hsa-miR-28-000411 0.236285791 -0.2313412459
## 128    hsa-miR-28-3p-002446 0.038137914 -0.0382123417
## 129      hsa-miR-296-000527 0.082827994  0.2526903116
## 130   hsa-miR-296-3p-002101 0.434123827  1.2287006858
## 131      hsa-miR-298-002190 0.255994860 -0.1171807739
## 132   hsa-miR-299-3p-001015 0.337924286 -0.2694851835
## 133   hsa-miR-299-5p-000600 0.640966561 -2.7056921922
## 134      hsa-miR-29a-002112 0.387897390  0.8134041873
## 135      hsa-miR-29b-000413 0.262591939  0.7989101806
## 136      hsa-miR-29c-000587 0.428612514 -2.6680573350
## 137      hsa-miR-301-000528 0.315342491 -0.8851085141
## 138     hsa-miR-301b-002392 0.375939609 -0.8378956389
## 139     hsa-miR-302a-000529 0.266511307  1.7874144201
## 140     hsa-miR-302b-000531 0.089617857 -0.4633827867
## 141     hsa-miR-302c-000533 0.107472122  0.2623771002
## 142      hsa-miR-30b-000602 1.277933609 -0.2652674038
## 143      hsa-miR-30c-000419 0.125678843 -0.1121639149
## 144       hsa-miR-31-002279 0.334982837 -1.1521086384
## 145       hsa-miR-32-002109 0.582015956  1.6552571174
## 146      hsa-miR-320-002277 0.023003496 -0.0098270402
## 147   hsa-miR-323-3p-002227 0.366307236 -1.3826936505
## 148   hsa-miR-324-3p-002161 0.142229726 -0.1958114079
## 149   hsa-miR-324-5p-000539 0.125802970 -0.2627097895
## 150      hsa-miR-325-000540 0.255994860 -0.1171807739
## 151      hsa-miR-326-000542 0.255994860 -0.1171807739
## 152      hsa-miR-328-000543 0.533859889 -1.0393399247
## 153      hsa-miR-329-001101 0.005874849 -0.0261564909
## 154      hsa-miR-330-000544 0.507953448 -1.3275568416
## 155   hsa-miR-330-5p-002230 0.255994860 -0.1171807739
## 156      hsa-miR-331-000545 0.134491450 -0.4463455994
## 157   hsa-miR-331-5p-002233 0.013985224  0.0288539800
## 158      hsa-miR-335-000546 0.000160989 -0.0001930824
## 159   hsa-miR-337-5p-002156 0.614370091 -2.3064886583
## 160   hsa-miR-338-3p-002252 0.355171932  0.4072884434
## 161   hsa-miR-339-3p-002184 0.202124417  0.0742130163
## 162   hsa-miR-339-5p-002257 0.339548422 -0.2904522497
## 163      hsa-miR-33b-002085 0.255994860 -0.1171807739
## 164      hsa-miR-340-002258 0.289203668 -0.9798627730
## 165   hsa-miR-342-3p-002260 0.111310223 -0.2751318625
## 166   hsa-miR-342-5p-002147 0.255994860 -0.1171807739
## 167      hsa-miR-345-002186 0.383581419  0.4244203309
## 168      hsa-miR-346-000553 0.255994860 -0.1171807739
## 169      hsa-miR-34a-000426 0.488486999  0.6510970850
## 170      hsa-miR-34c-000428 0.255081259  0.9446931482
## 171      hsa-miR-361-000554 1.320747595 -0.6502774109
## 172      hsa-miR-362-001273 0.445184759  0.3766160122
## 173   hsa-miR-362-3p-002117 0.375692275  0.8165535458
## 174      hsa-miR-363-001271 0.329769983 -1.0460044371
## 175      hsa-miR-365-001020 0.238102286 -0.5922438150
## 176      hsa-miR-367-000555 0.903734147 -1.0536457150
## 177   hsa-miR-369-3p-000557 0.683333310 -1.8068111787
## 178   hsa-miR-369-5p-001021 0.304316508  1.4494781183
## 179      hsa-miR-370-002275 0.340059371 -1.1312677862
## 180   hsa-miR-371-3p-002124 0.255994860 -0.1171807739
## 181      hsa-miR-372-000560 0.398672572  2.7801127048
## 182      hsa-miR-373-000561 0.112924249 -0.2263293055
## 183      hsa-miR-374-000563 0.075649656  0.1743586186
## 184      hsa-miR-375-000564 0.304507516 -1.3714696806
## 185     hsa-miR-376a-000565 0.281944808 -0.8766492638
## 186     hsa-miR-376b-001102 0.806651167  0.9670756630
## 187     hsa-miR-376c-002122 0.280840881 -0.9083157566
## 188      hsa-miR-377-000566 0.109297566 -0.3078145577
## 189   hsa-miR-380-3p-000569 0.331377363 -1.0954427176
## 190      hsa-miR-381-000571 0.522939315 -2.1980590438
## 191      hsa-miR-382-000572 0.461131040 -1.5443336921
## 192      hsa-miR-383-000573 0.206950789 -0.5764518707
## 193      hsa-miR-384-000574 0.362294421  0.5525911611
## 194   hsa-miR-409-5p-002331 0.135316272  0.6720340248
## 195      hsa-miR-410-001274 0.401304757 -1.3056894287
## 196      hsa-miR-411-001610 0.321380654 -1.0237806132
## 197      hsa-miR-412-001023 0.255994860 -0.1171807739
## 198     hsa-miR-422a-002297 0.339526963  0.1752192560
## 199   hsa-miR-423-5p-002340 0.250731072  0.1008092962
## 200      hsa-miR-424-000604 0.200601349  0.4012390730
## 201   hsa-miR-425-5p-001516 0.246573223  0.4534433735
## 202      hsa-miR-429-001024 0.801896322 -2.3439468738
## 203      hsa-miR-431-001979 0.409488844  1.0313295067
## 204      hsa-miR-433-001028 0.216524327 -0.6034215585
## 205      hsa-miR-448-001029 0.255994860 -0.1171807739
## 206      hsa-miR-449-001030 0.486640034  1.5882905837
## 207     hsa-miR-449b-001608 0.216079851 -1.2767290077
## 208     hsa-miR-450a-002303 0.108271014  0.0955109936
## 209  hsa-miR-450b-3p-002208 0.255994860 -0.1171807739
## 210  hsa-miR-450b-5p-002207 0.215125390  0.3857565327
## 211      hsa-miR-452-002329 0.627771866 -2.5688674147
## 212      hsa-miR-453-002318 0.401570861 -0.8197793842
## 213      hsa-miR-454-002323 0.196410583 -0.2588999086
## 214      hsa-miR-455-001280 0.006879999  0.0103409217
## 215   hsa-miR-455-3p-002244 0.041417151  0.0478090508
## 216   hsa-miR-483-5p-002338 1.034838503 -1.1675209396
## 217      hsa-miR-484-001821 0.356574279  0.6928370230
## 218   hsa-miR-485-3p-001277 0.150909650 -0.5424172781
## 219   hsa-miR-485-5p-001036 0.335002587 -1.1500518489
## 220      hsa-miR-486-001278 0.397715665 -1.3345047139
## 221   hsa-miR-486-3p-002093 0.255994860 -0.1171807739
## 222     hsa-miR-487a-001279 0.018912569 -0.1088397795
## 223     hsa-miR-487b-001285 0.325555962 -1.0868619563
## 224      hsa-miR-488-002357 0.255994860 -0.1171807739
## 225      hsa-miR-489-002358 1.381918774 -0.5682239157
## 226      hsa-miR-490-001037 0.370936981 -1.1423163626
## 227   hsa-miR-491-3p-002360 0.255994860 -0.1171807739
## 228      hsa-miR-492-001039 0.255994860 -0.1171807739
## 229      hsa-miR-493-002364 0.360166288 -1.2520346260
## 230      hsa-miR-494-002365 0.394909134 -1.1699172298
## 231   hsa-miR-499-3p-002427 0.255994860 -0.1171807739
## 232      hsa-miR-500-002428 0.271427642  0.1471996823
## 233      hsa-miR-501-001047 0.434582265  0.4187318847
## 234   hsa-miR-501-3p-002435 0.255994860 -0.1171807739
## 235      hsa-miR-502-001109 0.729776710 -1.3764978710
## 236   hsa-miR-502-3p-002083 1.084725142  0.6954102729
## 237      hsa-miR-503-001048 0.101917331  0.1037609409
## 238      hsa-miR-504-002084 0.255994860 -0.1171807739
## 239      hsa-miR-505-002089 0.373543774 -5.8489130681
## 240      hsa-miR-506-001050 0.255994860 -0.1171807739
## 241      hsa-miR-507-001051 0.255994860 -0.1171807739
## 242      hsa-miR-508-001052 0.574021018 -0.9433156182
## 243   hsa-miR-508-5p-002092 0.255994860 -0.1171807739
## 244 hsa-miR-509-3-5p-002155 0.255994860 -0.1171807739
## 245   hsa-miR-509-5p-002235 0.255994860 -0.1171807739
## 246      hsa-miR-510-002241 0.255994860 -0.1171807739
## 247      hsa-miR-511-001111 0.630736965 -2.6126720406
## 248   hsa-miR-512-3p-001823 0.007889482  0.0380912301
## 249   hsa-miR-512-5p-001145 0.223041540 -0.0991078672
## 250   hsa-miR-513-5p-002090 0.255994860 -0.1171807739
## 251   hsa-miR-515-3p-002369 0.070626441  0.0779352136
## 252   hsa-miR-515-5p-001112 0.448071850 -0.2053401931
## 253  hsa-miR-516a-5p-002416 0.255994860 -0.1171807739
## 254     hsa-miR-516b-001150 0.239105986  0.6469318941
## 255     hsa-miR-517a-002402 0.133726403  0.5494662692
## 256     hsa-miR-517b-001152 0.496611236 -0.6978128987
## 257     hsa-miR-517c-001153 0.233793438 -1.1180680839
## 258  hsa-miR-518a-3p-002397 0.074773853  0.3249137292
## 259  hsa-miR-518a-5p-002396 0.255994860 -0.1171807739
## 260     hsa-miR-518b-001156 0.045865160 -0.2645060459
## 261     hsa-miR-518c-002401 0.255994860 -0.1171807739
## 262     hsa-miR-518d-001159 0.025364465 -0.0692819584
## 263  hsa-miR-518d-5p-002389 0.142000879  0.5686164765
## 264     hsa-miR-518e-002395 0.293418094  0.9476140455
## 265     hsa-miR-518f-002388 0.037212425 -0.1932695514
## 266     hsa-miR-519a-002415 0.003369902  0.0149099800
## 267     hsa-miR-519c-001163 0.748147852  0.7038035210
## 268     hsa-miR-519d-002403 0.025562190  0.1222608818
## 269     hsa-miR-519e-002370 0.255994860 -0.1171807739
## 270    hsa-miR-520a#-001168 0.360352219  0.4979403771
## 271     hsa-miR-520a-001167 0.255994860 -0.1171807739
## 272     hsa-miR-520b-001116 0.134948494  0.3730723070
## 273  hsa-miR-520d-5p-002393 0.255994860 -0.1171807739
## 274     hsa-miR-520e-001119 0.569657960 -0.8163122391
## 275     hsa-miR-520f-001120 0.483389134 -0.6291016004
## 276     hsa-miR-520g-001121 0.295141843  1.0054731944
## 277      hsa-miR-521-001122 0.255994860 -0.1171807739
## 278      hsa-miR-522-002413 0.326607866 -1.8680251707
## 279      hsa-miR-523-002386 0.414928459 -1.6662419751
## 280   hsa-miR-524-5p-001982 0.255994860 -0.1171807739
## 281      hsa-miR-525-001174 0.255994860 -0.1171807739
## 282   hsa-miR-525-3p-002385 0.401185417  0.8143455420
## 283     hsa-miR-526b-002382 0.005154054 -0.0132099226
## 284      hsa-miR-532-001518 0.115426573  0.0502779784
## 285   hsa-miR-532-3p-002355 0.671000091 -0.3801551737
## 286      hsa-miR-539-001286 0.352038785 -1.1512667987
## 287      hsa-miR-541-002201 0.336736502 -1.1052187296
## 288   hsa-miR-542-3p-001284 0.502662096 -0.5812744742
## 289   hsa-miR-542-5p-002240 0.225241879 -0.6334893236
## 290      hsa-miR-544-002265 0.100268411  0.1118895667
## 291      hsa-miR-545-002267 0.262529452 -0.3506681679
## 292     hsa-miR-548a-001538 0.325126426  0.4383392294
## 293  hsa-miR-548a-5p-002412 0.255994860 -0.1171807739
## 294     hsa-miR-548b-001541 0.255994860 -0.1171807739
## 295  hsa-miR-548b-5p-002408 0.071457813 -0.2090061724
## 296     hsa-miR-548c-001590 0.255994860 -0.1171807739
## 297  hsa-miR-548c-5p-002429 0.964124435  1.1380438407
## 298     hsa-miR-548d-001605 1.003858606  2.5788666687
## 299  hsa-miR-548d-5p-002237 0.683455079  2.3557947933
## 300     hsa-miR-551b-001535 0.120491704 -0.3009302979
## 301   hsa-miR-556-3p-002345 0.255994860 -0.1171807739
## 302   hsa-miR-556-5p-002344 0.255994860 -0.1171807739
## 303      hsa-miR-561-001528 0.255994860 -0.1171807739
## 304      hsa-miR-570-002347 0.826997084  0.9932043238
## 305   hsa-miR-574-3p-002349 0.434833091 -1.1754220102
## 306   hsa-miR-576-3p-002351 0.442523526  0.3497125907
## 307   hsa-miR-576-5p-002350 0.073258609 -0.2117884535
## 308      hsa-miR-579-002398 0.255851171  0.2020152657
## 309   hsa-miR-582-3p-002399 0.255994860 -0.1171807739
## 310   hsa-miR-582-5p-001983 0.255994860 -0.1171807739
## 311      hsa-miR-589-002409 0.300937192  0.9465008187
## 312   hsa-miR-590-5p-001984 0.145250090  0.4866486993
## 313      hsa-miR-597-001551 0.070298667  0.1117351445
## 314      hsa-miR-598-001988 0.403605533 -0.9515676668
## 315   hsa-miR-615-5p-002353 0.255994860 -0.1171807739
## 316      hsa-miR-616-002414 0.331962153  0.9824555911
## 317      hsa-miR-618-001593 0.196114066  0.1638247774
## 318      hsa-miR-624-002430 0.803973111  1.4324294042
## 319      hsa-miR-625-002431 0.550964950  1.6642402954
## 320      hsa-miR-627-001560 0.037735642 -0.0806250090
## 321   hsa-miR-628-5p-002433 0.391841289 -0.8950047438
## 322      hsa-miR-629-002436 0.283072641  0.4649016972
## 323      hsa-miR-636-002088 0.464905051  0.5879215231
## 324      hsa-miR-642-001592 0.259593722 -0.1268656438
## 325      hsa-miR-651-001604 0.255994860 -0.1171807739
## 326      hsa-miR-652-002352 0.567419045  0.8889052605
## 327      hsa-miR-653-002292 0.821562443 -0.3963063140
## 328      hsa-miR-654-001611 0.006539006 -0.0402658988
## 329   hsa-miR-654-3p-002239 0.509560575 -2.3155624727
## 330      hsa-miR-655-001612 0.325404980 -0.9981079683
## 331      hsa-miR-660-001515 0.200808922 -0.3372566003
## 332   hsa-miR-671-3p-002322 0.220967822  0.4250347325
## 333      hsa-miR-672-002327 0.255994860 -0.1171807739
## 334      hsa-miR-674-002021 0.255994860 -0.1171807739
## 335      hsa-miR-708-002341 0.043171314  0.1266510252
## 336      hsa-miR-744-002324 0.439316846 -1.0280410691
## 337      hsa-miR-758-001990 0.612354784 -1.8491280187
## 338      hsa-miR-871-002354 0.255994860 -0.1171807739
## 339      hsa-miR-872-002264 0.255994860 -0.1171807739
## 340      hsa-miR-873-002356 0.509376872 -0.4594590367
## 341   hsa-miR-875-3p-002204 0.255994860 -0.1171807739
## 342   hsa-miR-876-3p-002225 0.819843393  0.9656518803
## 343   hsa-miR-876-5p-002205 0.255994860 -0.1171807739
## 344   hsa-miR-885-3p-002372 0.255994860 -0.1171807739
## 345   hsa-miR-885-5p-002296 0.061842105 -0.1082721151
## 346   hsa-miR-886-3p-002194 0.353211916  0.8955460747
## 347   hsa-miR-886-5p-002193 0.174682112 -0.1047804979
## 348      hsa-miR-887-002374 0.255994860 -0.1171807739
## 349      hsa-miR-888-002212 0.385760266  0.6926891850
## 350      hsa-miR-889-002202 0.165460556  0.8747251230
## 351      hsa-miR-890-002209 0.134917084  0.4133110052
## 352     hsa-miR-891a-002191 0.314228154  0.8981568552
## 353     hsa-miR-891b-002210 0.255994860 -0.1171807739
## 354     hsa-miR-892a-002195 0.255994860 -0.1171807739
## 355        hsa-miR-9-000583 0.007111830 -0.0366537561
## 356      hsa-miR-92a-000431 0.437401193  1.6370131913
## 357       hsa-miR-95-000433 0.746242738 -3.2421727732
## 358       hsa-miR-98-000577 0.350224776 -0.3652345438
## 359      hsa-miR-99a-000435 0.541268517 -0.4592753811
## 360      hsa-miR-99b-000436 0.460596581  0.2377538258

#Grafica de vulcano

vulcano <- ggplot(Logs, mapping = aes(x=LFC,
                                      y=LPV))+
  geom_point(size = 2,
             color = "gray")+
  theme_classic()+
  labs(title="Analisis comparativo de miRNAs",
       caption = "Creador: Paulina Aguilar",
       x = "Log2 (2-DDCT)",
       y= "-Log10 (valor de p)")
vulcano

#Limites

limite_p <- 0.05

Limite_FC <- 1.5

down_regulated <- Logs %>% 
  filter(LFC < -log2(Limite_FC),
         LPV > -log10(limite_p))

down_regulated
##                  Gen      LPV        LFC
## 1 hsa-miR-361-000554 1.320748 -0.6502774
up_regulated <- Logs %>% 
  filter(LFC > log2(Limite_FC),
         LPV > -log10(limite_p))
up_regulated
## [1] Gen LPV LFC
## <0 rows> (or 0-length row.names)
top_down_regulated <- down_regulated %>% 
  arrange(desc(LPV)) %>% 
  head(5)

top_down_regulated
##                  Gen      LPV        LFC
## 1 hsa-miR-361-000554 1.320748 -0.6502774
top_up_regulated <- up_regulated %>% 
  arrange(desc(LPV)) %>% 
  head(5)

top_up_regulated
## [1] Gen LPV LFC
## <0 rows> (or 0-length row.names)

#Mejorar la grafica

vulcano2 <- vulcano+
  geom_hline(yintercept = -log10(limite_p),
             linetype = "dashed")+
  geom_vline(xintercept = c(-log2(Limite_FC),log2(Limite_FC)),
             linetype = "dashed")
vulcano2

#solucion con chatgpt, no cambiaba color. #no hay datos que cumplan con caracteristicas de “up regulated”

vulcano3 <- vulcano2 +
  geom_point(data = up_regulated,
             aes(x = LFC, y = LPV),
             color = "#E64B35B2",
             alpha = 1,
             size = 3,
             inherit.aes = FALSE) +
  geom_point(data = down_regulated,
             aes(x = LFC, y = LPV),
             color = "#3C5488B2",
             alpha = 1,
             size = 3,
             inherit.aes = FALSE)

vulcano3 

vulcano4 <- vulcano3 +
  geom_label_repel(data = top_up_regulated,
                   aes(x = LFC, y = LPV, label = Gen),
                   box.padding = unit(0.35, "lines"),
                   point.padding = unit(0.5, "lines"),
                   segment.color = "grey50",
                   segment.size = 0.2,
                   max.overlaps = 50,
                   nudge_x = 0.5,
                   nudge_y = 0.5,
                   show.legend = FALSE) +
  geom_label_repel(data = top_down_regulated,
                   aes(x = LFC, y = LPV, label = Gen),
                   box.padding = unit(0.35, "lines"),
                   point.padding = unit(0.5, "lines"),
                   segment.color = "grey50",
                   segment.size = 0.2,
                   max.overlaps = 50,
                   nudge_x = -0.5,
                   nudge_y = -0.5,
                   show.legend = FALSE)

vulcano4

ggsave("vulcano4.jpg",
       plot = vulcano4,
       height = 5, width = 6,
       dpi = 300)