Case-control Analysis for Risk Factors of Childhood Blood Level

Author

ICMR

Part 3. Multivariable analysis for adjusted associations with risk factors

The causal graph of risk factors for high blood lead levels is complex with multiple interrelated factors (shown below). We will build a multivariable model to identify the risk factors for blood lead levels, while adjusting for potential confounders.

A. Household construction characteristics

Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Years of construction of current house 174




    Less than 10 years
— —


    More than 10 years
1.52 0.81, 2.88 0.2 57.1 19.7
PSU Rural/Urban 174




    Rural
— —


    Urban
3.96 1.78, 9.33 0.001

Wealth Index 174




    Highest
— —


    Higher
0.58 0.16, 2.08 0.4

    Middle
0.46 0.13, 1.58 0.2

    Lower
0.72 0.22, 2.37 0.6

    Lowest
0.87 0.29, 2.56 0.8

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Visible peeling paint in current house 173




    No
— —


    Yes
0.98 0.48, 1.97
0.9
40.5 -1
PSU Rural/Urban 173




    Rural
— —


    Urban
4.35 1.90, 10.6 <0.001

Wealth Index 173




    Highest
— —


    Higher
0.46 0.12, 1.65 0.2

    Middle
0.45 0.13, 1.56 0.2

    Lower
0.81 0.24, 2.65 0.7

    Lowest
0.89 0.29, 2.66 0.8

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
paint_type_current_hh 175




    No paint/Cement paint
— —


    Distemper
1.26 0.46, 3.53 0.7 29.8 6.2
    Chuna or similar
1.55 0.63, 4.00 0.4 39.3 13.9
    Emulsion
4.88 1.17, 23.4 0.036 16.7 13.2
PSU Rural/Urban 175




    Rural
— —


    Urban
3.89 1.66, 9.66 0.002

Wealth Index 175




    Highest
— —


    Higher
0.57 0.15, 2.15 0.4

    Middle
0.53 0.14, 1.95 0.3

    Lower
1.00 0.29, 3.44
0.9


    Lowest
1.20 0.38, 3.84 0.8

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Primary flooring type in household 93




    Non-soil-contact
— —


    Soil-contact
3.91 1.61, 10.1 0.003 35.7 26.6
PSU Rural/Urban 93




    Rural
— —


    Urban
3.16 0.85, 13.3 0.10

Wealth Index 93




    Highest
— —


    Higher
0.91 0.05, 15.1
0.9


    Middle
0.93 0.11, 9.27
0.9


    Lower
1.71 0.19, 18.0 0.6

    Lowest
1.06 0.14, 9.85
0.9


1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Smoking inside household 176




    No
— —


    Yes
1.79 0.95, 3.45 0.076 56 24.7
PSU Rural/Urban 176




    Rural
— —


    Urban
4.25 1.91, 10.1 <0.001

Wealth Index 176




    Highest
— —


    Higher
0.52 0.14, 1.84 0.3

    Middle
0.40 0.11, 1.42 0.2

    Lower
0.76 0.23, 2.49 0.7

    Lowest
0.78 0.26, 2.33 0.7

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Car/machine repair activity near household 173




    No
— —


    Yes
1.62 0.36, 7.60 0.5 6 2.3
PSU Rural/Urban 173




    Rural
— —


    Urban
4.53 2.01, 11.0 <0.001

Wealth Index 173




    Highest
— —


    Higher
0.44 0.12, 1.58 0.2

    Middle
0.35 0.09, 1.25 0.11

    Lower
0.78 0.22, 2.61 0.7

    Lowest
0.78 0.25, 2.39 0.7

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio
Characteristic N Adjusted OR1 95% CI p-value % exposed cases PAF (%)
Presence of old metal pipes 174




    No
— —


    Yes
4.03 1.41, 13.5 0.014 19 14.3
PSU Rural/Urban 174




    Rural
— —


    Urban
3.70 1.65, 8.76 0.002

Wealth Index 174




    Highest
— —


    Higher
0.36 0.09, 1.35 0.14

    Middle
0.39 0.11, 1.39 0.2

    Lower
0.76 0.23, 2.49 0.6

    Lowest
0.83 0.27, 2.47 0.7

1 Adjusted for rural/urban and wealth index
Abbreviations: CI = Confidence Interval, OR = Odds Ratio