##chargement des packages----
library(questionr)
library(tidyverse)
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.1 ✔ readr 2.1.4
## ✔ forcats 1.0.0 ✔ stringr 1.5.0
## ✔ ggplot2 3.4.2 ✔ tibble 3.2.1
## ✔ lubridate 1.9.2 ✔ tidyr 1.3.0
## ✔ purrr 1.0.1
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag() masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
library(tableone)
library(labelled)
library(gtsummary)
## #BlackLivesMatter
library(GGally)
## Registered S3 method overwritten by 'GGally':
## method from
## +.gg ggplot2
library(readxl)
library(effects)
## Le chargement a nécessité le package : carData
## lattice theme set by effectsTheme()
## See ?effectsTheme for details.
library(survival)
library(survminer)
## Le chargement a nécessité le package : ggpubr
##
## Attachement du package : 'survminer'
##
## L'objet suivant est masqué depuis 'package:survival':
##
## myeloma
library(ggplot2)
library(dplyr)
library(knitr)
library(cowplot)
##
## Attachement du package : 'cowplot'
##
## L'objet suivant est masqué depuis 'package:ggpubr':
##
## get_legend
##
## L'objet suivant est masqué depuis 'package:lubridate':
##
## stamp
##chargement des données
recap_survies_v2026034 <- read_excel("Y:/fp/FAC/2025-2026/Thèses/Camille Dujols/analyses_stats/20250304/recap_survies_v2026034.xlsx")
## Warning: Expecting numeric in L4778 / R4778C12: got 'ICR 3110'
## Warning: Expecting numeric in L4779 / R4779C12: got 'IUC 6520'
## Warning: Expecting numeric in L4780 / R4780C12: got 'IUC 6550'
## Warning: Expecting numeric in L4781 / R4781C12: got 'ICR 3160'
## Warning: Expecting numeric in L4782 / R4782C12: got 'IUC 6510'
## Warning: Expecting numeric in L4783 / R4783C12: got 'IUC 6520'
## Warning: Expecting numeric in L4784 / R4784C12: got 'IUC 6560'
## Warning: Expecting numeric in L4785 / R4785C12: got 'ICR 3110'
## Warning: Expecting numeric in L4786 / R4786C12: got 'IUC 6510'
## Warning: Expecting numeric in L4787 / R4787C12: got 'ICR 3160'
## Warning: Expecting numeric in L4788 / R4788C12: got 'IUC 6320'
## Warning: Expecting numeric in L4789 / R4789C12: got 'IUC 6530'
## Warning: Expecting numeric in L4790 / R4790C12: got 'ICR 3110'
## Warning: Expecting numeric in L4791 / R4791C12: got 'ICR 3110'
## Warning: Expecting numeric in L4792 / R4792C12: got 'ICR 3110'
## Warning: Expecting numeric in L4793 / R4793C12: got 'IUC 6560'
## Warning: Expecting numeric in L4794 / R4794C12: got 'IUC 6510'
## Warning: Expecting numeric in L4795 / R4795C12: got 'IUC 6510'
## Warning: Expecting numeric in L4796 / R4796C12: got 'IUC 6560'
## Warning: Expecting numeric in L4797 / R4797C12: got 'IUC 6520'
## Warning: Expecting numeric in L4798 / R4798C12: got 'IUC 6510'
## Warning: Expecting numeric in L4799 / R4799C12: got 'IUC 6510'
## Warning: Expecting numeric in L4800 / R4800C12: got 'IUC 6520'
## Warning: Expecting numeric in L4801 / R4801C12: got 'IUC 6510'
## Warning: Expecting numeric in L4802 / R4802C12: got 'IUC 6560'
## Warning: Expecting numeric in L4803 / R4803C12: got 'ICR 3160'
## Warning: Expecting numeric in L4804 / R4804C12: got 'IUC 1072'
## Warning: Expecting numeric in L4805 / R4805C12: got 'IUC 6520'
## Warning: Expecting numeric in L4806 / R4806C12: got 'IUC 6530'
## Warning: Expecting numeric in L4807 / R4807C12: got 'IUC 6560'
## Warning: Expecting numeric in L4808 / R4808C12: got 'IUC 6530'
## Warning: Expecting numeric in L4809 / R4809C12: got 'IUC 6510'
## Warning: Expecting numeric in L4810 / R4810C12: got 'IUC 6510'
## Warning: Expecting numeric in L4811 / R4811C12: got 'ICR 3160'
## Warning: Expecting numeric in L4812 / R4812C12: got 'IUC 6550'
## Warning: Expecting numeric in L4813 / R4813C12: got 'IUC 6510'
## Warning: Expecting numeric in L4814 / R4814C12: got 'IUC 6510'
## Warning: Expecting numeric in L4815 / R4815C12: got 'ICR 3185'
## Warning: Expecting numeric in L4816 / R4816C12: got 'ICR 3120'
## Warning: Expecting numeric in L4817 / R4817C12: got 'ICR 3160'
## Warning: Expecting numeric in L4818 / R4818C12: got 'ICR 3110'
## Warning: Expecting numeric in L4819 / R4819C12: got 'IUC 6510'
## Warning: Expecting numeric in L4820 / R4820C12: got 'IUC 6510'
## Warning: Expecting numeric in L4821 / R4821C12: got 'ICR 3120'
## Warning: Expecting numeric in L4822 / R4822C12: got 'IUC 6550'
## Warning: Expecting numeric in L4823 / R4823C12: got 'ICR 3110'
## Warning: Expecting numeric in L4824 / R4824C12: got 'IUC 6510'
## Warning: Expecting numeric in L4825 / R4825C12: got 'IUC 6510'
## Warning: Expecting numeric in L4826 / R4826C12: got 'ICR 3160'
## Warning: Expecting numeric in L4827 / R4827C12: got 'ICR 3160'
## Warning: Expecting numeric in L4828 / R4828C12: got 'IUC 6510'
## Warning: Expecting numeric in L4829 / R4829C12: got 'IUC 6510'
## Warning: Expecting numeric in L4830 / R4830C12: got 'IUC 6530'
## Warning: Expecting numeric in L4831 / R4831C12: got 'IUC 6520'
## Warning: Expecting numeric in L4832 / R4832C12: got 'ICR 3160'
## Warning: Expecting numeric in L4833 / R4833C12: got 'ICR 3160'
## Warning: Expecting numeric in L4834 / R4834C12: got 'ICR 3110'
## Warning: Expecting numeric in L4835 / R4835C12: got 'ICR 1ACC'
## Warning: Expecting numeric in L4836 / R4836C12: got 'ICR 3110'
## Warning: Expecting numeric in L4837 / R4837C12: got 'ICR 3110'
## Warning: Expecting numeric in L4838 / R4838C12: got 'ICR 3133'
## Warning: Expecting numeric in L4839 / R4839C12: got 'ICR 3133'
## Warning: Expecting numeric in L4840 / R4840C12: got 'ICR 3160'
## Warning: Expecting numeric in L4841 / R4841C12: got 'IUC 6530'
## Warning: Expecting numeric in L4842 / R4842C12: got 'IUC 6560'
## Warning: Expecting numeric in L4843 / R4843C12: got 'ICR 3160'
## Warning: Expecting numeric in L4844 / R4844C12: got 'ICR 3110'
## Warning: Expecting numeric in L4845 / R4845C12: got 'IUC 6350'
## Warning: Expecting numeric in L4846 / R4846C12: got 'ICR 3160'
## Warning: Expecting numeric in L4847 / R4847C12: got 'ICR 3110'
## Warning: Expecting numeric in L4848 / R4848C12: got 'IUC 6560'
## Warning: Expecting numeric in L4849 / R4849C12: got 'ICR 3110'
## Warning: Expecting numeric in L4850 / R4850C12: got 'IUC 6560'
## Warning: Expecting numeric in L4851 / R4851C12: got 'IUC 6520'
## Warning: Expecting numeric in L4852 / R4852C12: got 'IUC 6550'
## Warning: Expecting numeric in L4853 / R4853C12: got 'ICR 3160'
## Warning: Expecting numeric in L4854 / R4854C12: got 'IUC 6560'
## Warning: Expecting numeric in L4855 / R4855C12: got 'ICR 3164'
## Warning: Expecting numeric in L4856 / R4856C12: got 'ICR 3160'
## Warning: Expecting numeric in L4857 / R4857C12: got 'IUC 6530'
## Warning: Expecting numeric in L4858 / R4858C12: got 'ICR 3185'
## Warning: Expecting numeric in L4859 / R4859C12: got 'ICR 3185'
## Warning: Expecting numeric in L4860 / R4860C12: got 'ICR 3120'
## Warning: Expecting numeric in L4861 / R4861C12: got 'ICR 3185'
## Warning: Expecting numeric in L4862 / R4862C12: got 'IUC 6560'
## Warning: Expecting numeric in L4863 / R4863C12: got 'ICR 3185'
## Warning: Expecting numeric in L4864 / R4864C12: got 'ICR 3160'
## Warning: Expecting numeric in L4865 / R4865C12: got 'ICR 3110'
## Warning: Expecting numeric in L4866 / R4866C12: got 'ICR 3160'
## Warning: Expecting numeric in L4867 / R4867C12: got 'ICR 3110'
## Warning: Expecting numeric in L4868 / R4868C12: got 'IUC 6510'
## Warning: Expecting numeric in L4869 / R4869C12: got 'ICR 3110'
## Warning: Expecting numeric in L4870 / R4870C12: got 'ICR 3160'
## Warning: Expecting numeric in L4871 / R4871C12: got 'IUC 6560'
## Warning: Expecting numeric in L4872 / R4872C12: got 'ICR 3110'
## Warning: Expecting numeric in L4873 / R4873C12: got 'ICR 3160'
## Warning: Expecting numeric in L4874 / R4874C12: got 'ICR 3133'
## Warning: Expecting numeric in L4875 / R4875C12: got 'IUC 6510'
## Warning: Expecting numeric in L4876 / R4876C12: got 'IUC 6530'
## Warning: Expecting numeric in L4877 / R4877C12: got 'ICR 3160'
## Warning: Expecting numeric in L4878 / R4878C12: got 'ICR 3133'
## Warning: Expecting numeric in L4879 / R4879C12: got 'ICR 3160'
## Warning: Expecting numeric in L4880 / R4880C12: got 'IUC 6550'
## Warning: Expecting numeric in L4881 / R4881C12: got 'ICR 3185'
## Warning: Expecting numeric in L4882 / R4882C12: got 'IUC 6560'
## Warning: Expecting numeric in L4883 / R4883C12: got 'IUC 6510'
## Warning: Expecting numeric in L4884 / R4884C12: got 'ICR 3160'
## Warning: Expecting numeric in L4885 / R4885C12: got 'ICR 3110'
## Warning: Expecting numeric in L4886 / R4886C12: got 'ICR 3160'
## Warning: Expecting numeric in L4887 / R4887C12: got 'ICR 3160'
## Warning: Expecting numeric in L4888 / R4888C12: got 'ICR 3162'
## Warning: Expecting numeric in L4889 / R4889C12: got 'IUC 6510'
## Warning: Expecting numeric in L4890 / R4890C12: got 'ICR 3160'
## Warning: Expecting numeric in L4891 / R4891C12: got 'ICR 3160'
## Warning: Expecting numeric in L4892 / R4892C12: got 'ICR 3120'
## Warning: Expecting numeric in L4893 / R4893C12: got 'ICR 3160'
## Warning: Expecting numeric in L4894 / R4894C12: got 'ICR 3160'
## Warning: Expecting numeric in L4895 / R4895C12: got 'ICR 3164'
## Warning: Expecting numeric in L4896 / R4896C12: got 'ICR 3120'
## Warning: Expecting numeric in L4897 / R4897C12: got 'ICR 3110'
## Warning: Expecting numeric in L4898 / R4898C12: got 'ICR 3160'
## Warning: Expecting numeric in L4899 / R4899C12: got 'ICR 3133'
## Warning: Expecting numeric in L4900 / R4900C12: got 'IUC 6530'
## Warning: Expecting numeric in L4901 / R4901C12: got 'ICR 3160'
## Warning: Expecting numeric in L4902 / R4902C12: got 'ICR 3160'
## Warning: Expecting numeric in L4903 / R4903C12: got 'IUC 6530'
## Warning: Expecting numeric in L4904 / R4904C12: got 'ICR 3185'
## Warning: Expecting numeric in L4905 / R4905C12: got 'ICR 3185'
## Warning: Expecting numeric in L4906 / R4906C12: got 'ICR 3160'
## Warning: Expecting numeric in L4907 / R4907C12: got 'IUC 1072'
## Warning: Expecting numeric in L4908 / R4908C12: got 'IUC 6510'
## Warning: Expecting numeric in L4909 / R4909C12: got 'IUC 6560'
## Warning: Expecting numeric in L4910 / R4910C12: got 'IUC 6520'
## Warning: Expecting numeric in L4911 / R4911C12: got 'ICR 3133'
## Warning: Expecting numeric in L4912 / R4912C12: got 'ICR 3160'
## Warning: Expecting numeric in L4913 / R4913C12: got 'IUC 6560'
## Warning: Expecting numeric in L4914 / R4914C12: got 'ICR 3160'
## Warning: Expecting numeric in L4915 / R4915C12: got 'ICR 3133'
## Warning: Expecting numeric in L4916 / R4916C12: got 'ICR 3160'
## Warning: Expecting numeric in L4917 / R4917C12: got 'ICR 3160'
## Warning: Expecting numeric in L4918 / R4918C12: got 'ICR 3160'
## Warning: Expecting numeric in L4919 / R4919C12: got 'ICR 3120'
## Warning: Expecting numeric in L4920 / R4920C12: got 'ICR 3110'
## Warning: Expecting numeric in L4921 / R4921C12: got 'IUC 6510'
## Warning: Expecting numeric in L4922 / R4922C12: got 'ICR 3110'
## Warning: Expecting numeric in L4923 / R4923C12: got 'IUC 6530'
## Warning: Expecting numeric in L4924 / R4924C12: got 'ICR 3110'
## Warning: Expecting numeric in L4925 / R4925C12: got 'IUC 6550'
## Warning: Expecting numeric in L4926 / R4926C12: got 'ICR 3110'
## Warning: Expecting numeric in L4927 / R4927C12: got 'ICR 3110'
## Warning: Expecting numeric in L4928 / R4928C12: got 'ICR 3133'
## Warning: Expecting numeric in L4929 / R4929C12: got 'ICR 3185'
## Warning: Expecting numeric in L4930 / R4930C12: got 'ICR 3110'
## Warning: Expecting numeric in L4931 / R4931C12: got 'ICR 3110'
## Warning: Expecting numeric in L4932 / R4932C12: got 'ICR 3110'
## Warning: Expecting numeric in L4933 / R4933C12: got 'ICR 3185'
## Warning: Expecting numeric in L4934 / R4934C12: got 'ICR 3160'
## Warning: Expecting numeric in L4935 / R4935C12: got 'ICR 3110'
## Warning: Expecting numeric in L4936 / R4936C12: got 'ICR 3120'
## Warning: Expecting numeric in L4937 / R4937C12: got 'ICR 3110'
## Warning: Expecting numeric in L4938 / R4938C12: got 'ICR 3133'
## Warning: Expecting numeric in L4939 / R4939C12: got 'ICR 3110'
## Warning: Expecting numeric in L4940 / R4940C12: got 'ICR 3110'
## Warning: Expecting numeric in L4941 / R4941C12: got 'ICR 3110'
## Warning: Expecting numeric in L4942 / R4942C12: got 'ICR 3185'
## Warning: Expecting numeric in L4943 / R4943C12: got 'ICR 3110'
## Warning: Expecting numeric in L4944 / R4944C12: got 'ICR 3120'
## Warning: Expecting numeric in L4945 / R4945C12: got 'ICR 3185'
## Warning: Expecting numeric in L4946 / R4946C12: got 'ICR 3110'
## Warning: Expecting numeric in L4947 / R4947C12: got 'ICR 3110'
## Warning: Expecting numeric in L4948 / R4948C12: got 'ICR 3110'
## Warning: Expecting numeric in L4949 / R4949C12: got 'ICR 3133'
## Warning: Expecting numeric in L4950 / R4950C12: got 'ICR 3110'
## Warning: Expecting numeric in L4951 / R4951C12: got 'ICR 3110'
## Warning: Expecting numeric in L4952 / R4952C12: got 'ICR 3160'
## Warning: Expecting numeric in L4953 / R4953C12: got 'ICR 3120'
## Warning: Expecting numeric in L4954 / R4954C12: got 'ICR 3133'
## Warning: Expecting numeric in L4955 / R4955C12: got 'ICR 3120'
## Warning: Expecting numeric in L4956 / R4956C12: got 'IUC 6560'
## Warning: Expecting numeric in L4957 / R4957C12: got 'ICR 3160'
## Warning: Expecting numeric in L4958 / R4958C12: got 'ICR 3160'
## Warning: Expecting numeric in L4959 / R4959C12: got 'ICR 3110'
## Warning: Expecting numeric in L4960 / R4960C12: got 'ICR 3110'
## Warning: Expecting numeric in L4961 / R4961C12: got 'ICR 3160'
## Warning: Expecting numeric in L4962 / R4962C12: got 'ICR 3110'
## Warning: Expecting numeric in L4963 / R4963C12: got 'ICR 3110'
## Warning: Expecting numeric in L4964 / R4964C12: got 'ICR 3164'
## Warning: Expecting numeric in L4965 / R4965C12: got 'ICR 3160'
## Warning: Expecting numeric in L4966 / R4966C12: got 'ICR 3120'
## Warning: Expecting numeric in L4967 / R4967C12: got 'ICR 3110'
## Warning: Expecting numeric in L4968 / R4968C12: got 'ICR 3110'
## Warning: Expecting numeric in L4969 / R4969C12: got 'ICR 3110'
## Warning: Expecting numeric in L4970 / R4970C12: got 'ICR 3110'
## Warning: Expecting numeric in L4971 / R4971C12: got 'ICR 3133'
## Warning: Expecting numeric in L4972 / R4972C12: got 'ICR 3110'
## Warning: Expecting numeric in L4973 / R4973C12: got 'ICR 3110'
## Warning: Expecting numeric in L4974 / R4974C12: got 'ICR 3110'
## Warning: Expecting numeric in L4975 / R4975C12: got 'ICR 3110'
## Warning: Expecting numeric in L4976 / R4976C12: got 'ICR 3160'
## Warning: Expecting numeric in L4977 / R4977C12: got 'ICR 3160'
## Warning: Expecting numeric in L4978 / R4978C12: got 'ICR 3185'
## Warning: Expecting numeric in L4979 / R4979C12: got 'ICR 3110'
## Warning: Expecting numeric in L4980 / R4980C12: got 'ICR 3160'
## Warning: Expecting numeric in L4981 / R4981C12: got 'ICR 3110'
## Warning: Expecting numeric in L4982 / R4982C12: got 'ICR 3133'
## Warning: Expecting numeric in L4983 / R4983C12: got 'ICR 3110'
## Warning: Expecting numeric in L4984 / R4984C12: got 'IUC 6530'
## Warning: Expecting numeric in L4985 / R4985C12: got 'IUC 6560'
## Warning: Expecting numeric in L4986 / R4986C12: got 'ICR 3110'
## Warning: Expecting numeric in L4987 / R4987C12: got 'ICR 3110'
## Warning: Expecting numeric in L4988 / R4988C12: got 'ICR 3164'
## Warning: Expecting numeric in L4989 / R4989C12: got 'ICR 3110'
## Warning: Expecting numeric in L4990 / R4990C12: got 'ICR 3110'
## Warning: Expecting numeric in L4991 / R4991C12: got 'ICR 3160'
## Warning: Expecting numeric in L4992 / R4992C12: got 'ICR 3110'
## Warning: Expecting numeric in L4993 / R4993C12: got 'ICR 3110'
## Warning: Expecting numeric in L4994 / R4994C12: got 'ICR 3110'
## Warning: Expecting numeric in L4995 / R4995C12: got 'ICR 3185'
## Warning: Expecting numeric in L4996 / R4996C12: got 'ICR 3110'
## Warning: Expecting numeric in L4997 / R4997C12: got 'ICR 3110'
## Warning: Expecting numeric in L4998 / R4998C12: got 'ICR 3110'
## Warning: Expecting numeric in L4999 / R4999C12: got 'ICR 3185'
## Warning: Expecting numeric in L5000 / R5000C12: got 'ICR 3110'
## Warning: Expecting numeric in L5001 / R5001C12: got 'IUC 6510'
## Warning: Expecting numeric in L5002 / R5002C12: got 'ICR 3110'
## Warning: Expecting numeric in L5003 / R5003C12: got 'ICR 3110'
## Warning: Expecting numeric in L5004 / R5004C12: got 'IUC 6553'
## Warning: Expecting numeric in L5005 / R5005C12: got 'ICR 3185'
## Warning: Expecting numeric in L5006 / R5006C12: got 'ICR 3110'
## Warning: Expecting numeric in L5007 / R5007C12: got 'ICR 3133'
## Warning: Expecting numeric in L5008 / R5008C12: got 'ICR 3110'
## Warning: Expecting numeric in L5009 / R5009C12: got 'IUC 6560'
## Warning: Expecting numeric in L5010 / R5010C12: got 'ICR 3110'
## Warning: Expecting numeric in L5011 / R5011C12: got 'ICR 3110'
## Warning: Expecting numeric in L5012 / R5012C12: got 'IUC 6510'
## Warning: Expecting numeric in L5013 / R5013C12: got 'ICR 3110'
## Warning: Expecting numeric in L5014 / R5014C12: got 'ICR 3120'
## Warning: Expecting numeric in L5015 / R5015C12: got 'IUC 6510'
## Warning: Expecting numeric in L5016 / R5016C12: got 'ICR 3110'
## Warning: Expecting numeric in L5017 / R5017C12: got 'ICR 3110'
## Warning: Expecting numeric in L5018 / R5018C12: got 'ICR 3110'
## Warning: Expecting numeric in L5019 / R5019C12: got 'ICR 3110'
## Warning: Expecting numeric in L5020 / R5020C12: got 'ICR 3120'
## Warning: Expecting numeric in L5021 / R5021C12: got 'IUC 6510'
## Warning: Expecting numeric in L5022 / R5022C12: got 'ICR 3110'
## Warning: Expecting numeric in L5023 / R5023C12: got 'IUC 6530'
## Warning: Expecting numeric in L5024 / R5024C12: got 'IUC 6560'
## Warning: Expecting numeric in L5025 / R5025C12: got 'ICR 3110'
## Warning: Expecting numeric in L5026 / R5026C12: got 'ICR 3160'
## Warning: Expecting numeric in L5027 / R5027C12: got 'ICR 3110'
## Warning: Expecting numeric in L5028 / R5028C12: got 'ICR 3110'
## Warning: Expecting numeric in L5029 / R5029C12: got 'ICR 3110'
## Warning: Expecting numeric in L5030 / R5030C12: got 'ICR 3110'
## Warning: Expecting numeric in L5031 / R5031C12: got 'IUC 6530'
## Warning: Expecting numeric in L5032 / R5032C12: got 'IUC 6530'
## Warning: Expecting numeric in L5033 / R5033C12: got 'IUC 6530'
## Warning: Expecting numeric in L5034 / R5034C12: got 'ICR 3110'
## Warning: Expecting numeric in L5035 / R5035C12: got 'ICR 3160'
## Warning: Expecting numeric in L5036 / R5036C12: got 'ICR 3110'
## Warning: Expecting numeric in L5037 / R5037C12: got 'ICR 3133'
## Warning: Expecting numeric in L5038 / R5038C12: got 'ICR 3110'
## Warning: Expecting numeric in L5039 / R5039C12: got 'ICR 3110'
## Warning: Expecting numeric in L5040 / R5040C12: got 'IUC 6510'
## Warning: Expecting numeric in L5041 / R5041C12: got 'IUC 6530'
## Warning: Expecting numeric in L5042 / R5042C12: got 'ICR 3110'
## Warning: Expecting numeric in L5043 / R5043C12: got 'ICR 3160'
## Warning: Expecting numeric in L5044 / R5044C12: got 'ICR 3110'
## Warning: Expecting numeric in L5045 / R5045C12: got 'IUC 6550'
## Warning: Expecting numeric in L5046 / R5046C12: got 'ICR 3185'
## Warning: Expecting numeric in L5047 / R5047C12: got 'ICR 3160'
## Warning: Expecting numeric in L5048 / R5048C12: got 'IUC 6550'
## Warning: Expecting numeric in L5049 / R5049C12: got 'ICR 3110'
## Warning: Expecting numeric in L5050 / R5050C12: got 'ICR 3110'
## Warning: Expecting numeric in L5051 / R5051C12: got 'ICR 3010'
## Warning: Expecting numeric in L5052 / R5052C12: got 'ICR 3185'
## Warning: Expecting numeric in L5053 / R5053C12: got 'ICR 3110'
## Warning: Expecting numeric in L5054 / R5054C12: got 'ICR 3110'
## Warning: Expecting numeric in L5055 / R5055C12: got 'ICR 3110'
## Warning: Expecting numeric in L5056 / R5056C12: got 'IUC 6560'
## Warning: Expecting numeric in L5057 / R5057C12: got 'ICR 3110'
## Warning: Expecting numeric in L5058 / R5058C12: got 'ICR 3110'
## Warning: Expecting numeric in L5059 / R5059C12: got 'ICR 3110'
## Warning: Expecting numeric in L5060 / R5060C12: got 'ICR 3110'
## Warning: Expecting numeric in L5061 / R5061C12: got 'ICR 3120'
## Warning: Expecting numeric in L5062 / R5062C12: got 'IUC 2023'
## Warning: Expecting numeric in L5063 / R5063C12: got 'IUC 6530'
## Warning: Expecting numeric in L5064 / R5064C12: got 'ICR 3110'
## Warning: Expecting numeric in L5065 / R5065C12: got 'ICR 3110'
## Warning: Expecting numeric in L5066 / R5066C12: got 'ICR 3160'
## Warning: Expecting numeric in L5067 / R5067C12: got 'ICR 3110'
## Warning: Expecting numeric in L5068 / R5068C12: got 'ICR 3185'
## Warning: Expecting numeric in L5069 / R5069C12: got 'IUC 6510'
## Warning: Expecting numeric in L5070 / R5070C12: got 'IUC 6550'
## Warning: Expecting numeric in L5071 / R5071C12: got 'IUC 6510'
## Warning: Expecting numeric in L5072 / R5072C12: got 'IUC 6550'
## Warning: Expecting numeric in L5073 / R5073C12: got 'IUC 6530'
## Warning: Expecting numeric in L5074 / R5074C12: got 'ICR 3160'
## Warning: Expecting numeric in L5075 / R5075C12: got 'ICR 3120'
## Warning: Expecting numeric in L5076 / R5076C12: got 'IUC 6510'
## Warning: Expecting numeric in L5077 / R5077C12: got 'IUC 6560'
## Warning: Expecting numeric in L5078 / R5078C12: got 'ICR 3120'
## Warning: Expecting numeric in L5079 / R5079C12: got 'ICR 3110'
## Warning: Expecting numeric in L5080 / R5080C12: got 'ICR 3110'
## Warning: Expecting numeric in L5081 / R5081C12: got 'ICR 3160'
## Warning: Expecting numeric in L5082 / R5082C12: got 'IUC 6520'
## Warning: Expecting numeric in L5083 / R5083C12: got 'ICR 3120'
## Warning: Expecting numeric in L5084 / R5084C12: got 'ICR 3010'
## Warning: Expecting numeric in L5085 / R5085C12: got 'IUC 6530'
## Warning: Expecting numeric in L5086 / R5086C12: got 'ICR 3110'
## Warning: Expecting numeric in L5087 / R5087C12: got 'ICR 3110'
## Warning: Expecting numeric in L5088 / R5088C12: got 'ICR 3110'
## Warning: Expecting numeric in L5089 / R5089C12: got 'ICR 3110'
## Warning: Expecting numeric in L5090 / R5090C12: got 'IUC 6530'
## Warning: Expecting numeric in L5091 / R5091C12: got 'ICR 3110'
## Warning: Expecting numeric in L5092 / R5092C12: got 'ICR 3110'
## Warning: Expecting numeric in L5093 / R5093C12: got 'ICR 3110'
## Warning: Expecting numeric in L5094 / R5094C12: got 'ICR 3160'
## Warning: Expecting numeric in L5095 / R5095C12: got 'ICR 3120'
## Warning: Expecting numeric in L5096 / R5096C12: got 'IUC 6520'
## Warning: Expecting numeric in L5097 / R5097C12: got 'ICR 3110'
## Warning: Expecting numeric in L5098 / R5098C12: got 'ICR 3110'
## Warning: Expecting numeric in L5099 / R5099C12: got 'IUC 6560'
## Warning: Expecting numeric in L5100 / R5100C12: got 'IUC 6510'
## Warning: Expecting numeric in L5101 / R5101C12: got 'IUC 6560'
## Warning: Expecting numeric in L5102 / R5102C12: got 'IUC 6560'
## Warning: Expecting numeric in L5103 / R5103C12: got 'IUC 6550'
## Warning: Expecting numeric in L5104 / R5104C12: got 'IUC 6510'
## Warning: Expecting numeric in L5105 / R5105C12: got 'IUC 6550'
## Warning: Expecting numeric in L5106 / R5106C12: got 'IUC 6520'
## Warning: Expecting numeric in L5107 / R5107C12: got 'IUC 6510'
## Warning: Expecting numeric in L5108 / R5108C12: got 'IUC 6560'
## Warning: Expecting numeric in L5109 / R5109C12: got 'IUC 6510'
## Warning: Expecting numeric in L5110 / R5110C12: got 'IUC 6510'
## Warning: Expecting numeric in L5111 / R5111C12: got 'IUC 2023'
## Warning: Expecting numeric in L5112 / R5112C12: got 'IUC 6520'
## Warning: Expecting numeric in L5113 / R5113C12: got 'IUC 6530'
## Warning: Expecting numeric in L5114 / R5114C12: got 'IUC 6510'
## Warning: Expecting numeric in L5115 / R5115C12: got 'IUC 6510'
## Warning: Expecting numeric in L5116 / R5116C12: got 'IUC 6560'
## Warning: Expecting numeric in L5117 / R5117C12: got 'IUC 6510'
## Warning: Expecting numeric in L5118 / R5118C12: got 'IUC 6510'
## Warning: Expecting numeric in L5119 / R5119C12: got 'IUC 6510'
## Warning: Expecting numeric in L5120 / R5120C12: got 'IUC 6530'
## Warning: Expecting numeric in L5121 / R5121C12: got 'IUC 6510'
## Warning: Expecting numeric in L5122 / R5122C12: got 'IUC 6510'
## Warning: Expecting numeric in L5123 / R5123C12: got 'IUC 6510'
## Warning: Expecting numeric in L5124 / R5124C12: got 'IUC 6350'
## Warning: Expecting numeric in L5125 / R5125C12: got 'IUC 6510'
## Warning: Expecting numeric in L5126 / R5126C12: got 'IUC 6510'
## Warning: Expecting numeric in L5127 / R5127C12: got 'IUC 6560'
## Warning: Expecting numeric in L5128 / R5128C12: got 'IUC 6510'
## Warning: Expecting numeric in L5129 / R5129C12: got 'IUC 6530'
## Warning: Expecting numeric in L5130 / R5130C12: got 'IUC 6510'
## Warning: Expecting numeric in L5131 / R5131C12: got 'IUC 6510'
## Warning: Expecting numeric in L5132 / R5132C12: got 'IUC 6550'
## Warning: Expecting numeric in L5133 / R5133C12: got 'IUC 6510'
## Warning: Expecting numeric in L5134 / R5134C12: got 'IUC 6510'
## Warning: Expecting numeric in L5135 / R5135C12: got 'IUC 6510'
## Warning: Expecting numeric in L5136 / R5136C12: got 'IUC 6310'
## Warning: Expecting numeric in L5137 / R5137C12: got 'IUC 6520'
## Warning: Expecting numeric in L5138 / R5138C12: got 'IUC 6560'
## Warning: Expecting numeric in L5139 / R5139C12: got 'IUC 6510'
## Warning: Expecting numeric in L5140 / R5140C12: got 'IUC 6510'
## Warning: Expecting numeric in L5141 / R5141C12: got 'IUC 6510'
## Warning: Expecting numeric in L5142 / R5142C12: got 'IUC 6550'
## Warning: Expecting numeric in L5143 / R5143C12: got 'IUC 6550'
## Warning: Expecting numeric in L5144 / R5144C12: got 'IUC 6530'
## Warning: Expecting numeric in L5145 / R5145C12: got 'IUC 6520'
## Warning: Expecting numeric in L5146 / R5146C12: got 'IUC 6550'
## Warning: Expecting numeric in L5147 / R5147C12: got 'IUC 6560'
## Warning: Expecting numeric in L5148 / R5148C12: got 'IUC 2023'
## Warning: Expecting numeric in L5149 / R5149C12: got 'IUC 6510'
## Warning: Expecting numeric in L5150 / R5150C12: got 'IUC 6510'
## Warning: Expecting numeric in L5151 / R5151C12: got 'IUC 6510'
## Warning: Expecting numeric in L5152 / R5152C12: got 'IUC 6550'
## Warning: Expecting numeric in L5153 / R5153C12: got 'IUC 6510'
## Warning: Expecting numeric in L5154 / R5154C12: got 'IUC 6530'
## Warning: Expecting numeric in L5155 / R5155C12: got 'IUC 6510'
## Warning: Expecting numeric in L5156 / R5156C12: got 'IUC 6520'
## Warning: Expecting numeric in L5157 / R5157C12: got 'IUC 6320'
## Warning: Expecting numeric in L5158 / R5158C12: got 'IUC 6530'
## Warning: Expecting numeric in L5159 / R5159C12: got 'IUC 6550'
## Warning: Expecting numeric in L5160 / R5160C12: got 'IUC 6530'
## Warning: Expecting numeric in L5161 / R5161C12: got 'IUC 6550'
## Warning: Expecting numeric in L5162 / R5162C12: got 'IUC 6550'
## Warning: Expecting numeric in L5163 / R5163C12: got 'IUC 6510'
## Warning: Expecting numeric in L5164 / R5164C12: got 'IUC 6350'
## Warning: Expecting numeric in L5165 / R5165C12: got 'IUC 6510'
## Warning: Expecting numeric in L5166 / R5166C12: got 'IUC 6520'
## Warning: Expecting numeric in L5167 / R5167C12: got 'IUC 6560'
## Warning: Expecting numeric in L5168 / R5168C12: got 'IUC 6550'
## Warning: Expecting numeric in L5169 / R5169C12: got 'IUC 6530'
## Warning: Expecting numeric in L5170 / R5170C12: got 'IUC 6510'
## Warning: Expecting numeric in L5171 / R5171C12: got 'IUC 6510'
## Warning: Expecting numeric in L5172 / R5172C12: got 'IUC 6560'
## Warning: Expecting numeric in L5173 / R5173C12: got 'IUC 6560'
## Warning: Expecting numeric in L5174 / R5174C12: got 'IUC 6550'
## Warning: Expecting numeric in L5175 / R5175C12: got 'IUC 6560'
## Warning: Expecting numeric in L5176 / R5176C12: got 'IUC 6560'
## Warning: Expecting numeric in L5177 / R5177C12: got 'IUC 6510'
## Warning: Expecting numeric in L5178 / R5178C12: got 'IUC 6560'
## Warning: Expecting numeric in L5179 / R5179C12: got 'IUC 6530'
## Warning: Expecting numeric in L5180 / R5180C12: got 'IUC 6520'
## Warning: Expecting numeric in L5181 / R5181C12: got 'IUC 6530'
## Warning: Expecting numeric in L5182 / R5182C12: got 'IUC 6530'
## Warning: Expecting numeric in L5183 / R5183C12: got 'IUC 6510'
## Warning: Expecting numeric in L5184 / R5184C12: got 'IUC 6510'
## Warning: Expecting numeric in L5185 / R5185C12: got 'IUC 6560'
## Warning: Expecting numeric in L5186 / R5186C12: got 'IUC 6530'
## Warning: Expecting numeric in L5187 / R5187C12: got 'IUC 6530'
## Warning: Expecting numeric in L5188 / R5188C12: got 'IUC 6530'
## Warning: Expecting numeric in L5189 / R5189C12: got 'IUC 6530'
## Warning: Expecting numeric in L5190 / R5190C12: got 'IUC 6560'
## Warning: Expecting numeric in L5191 / R5191C12: got 'IUC 6530'
## Warning: Expecting numeric in L5192 / R5192C12: got 'IUC 6510'
## Warning: Expecting numeric in L5193 / R5193C12: got 'IUC 6550'
## Warning: Expecting numeric in L5194 / R5194C12: got 'IUC 6310'
## Warning: Expecting numeric in L5195 / R5195C12: got 'IUC 6560'
## Warning: Expecting numeric in L5196 / R5196C12: got 'IUC 6560'
## Warning: Expecting numeric in L5197 / R5197C12: got 'IUC 6510'
## Warning: Expecting numeric in L5198 / R5198C12: got 'IUC 6510'
## Warning: Expecting numeric in L5199 / R5199C12: got 'IUC 6510'
## Warning: Expecting numeric in L5200 / R5200C12: got 'IUC 6560'
## Warning: Expecting numeric in L5201 / R5201C12: got 'IUC 6560'
## Warning: Expecting numeric in L5202 / R5202C12: got 'IUC 6550'
## Warning: Expecting numeric in L5203 / R5203C12: got 'IUC 6530'
## Warning: Expecting numeric in L5204 / R5204C12: got 'IUC 6510'
## Warning: Expecting numeric in L5205 / R5205C12: got 'IUC 6530'
## Warning: Expecting numeric in L5206 / R5206C12: got 'IUC 6530'
## Warning: Expecting numeric in L5207 / R5207C12: got 'IUC 6510'
## Warning: Expecting numeric in L5208 / R5208C12: got 'IUC 6550'
## Warning: Expecting numeric in L5209 / R5209C12: got 'IUC 6560'
## Warning: Expecting numeric in L5210 / R5210C12: got 'IUC 6510'
## Warning: Expecting numeric in L5211 / R5211C12: got 'IUC 6560'
## Warning: Expecting numeric in L5212 / R5212C12: got 'IUC 6510'
## Warning: Expecting numeric in L5213 / R5213C12: got 'IUC 6530'
## Warning: Expecting numeric in L5214 / R5214C12: got 'IUC 6550'
## Warning: Expecting numeric in L5215 / R5215C12: got 'IUC 6510'
## Warning: Expecting numeric in L5216 / R5216C12: got 'IUC 6560'
## Warning: Expecting numeric in L5217 / R5217C12: got 'IUC 6510'
## Warning: Expecting numeric in L5218 / R5218C12: got 'IUC 6550'
## Warning: Expecting numeric in L5219 / R5219C12: got 'IUC 6510'
## Warning: Expecting numeric in L5220 / R5220C12: got 'IUC 6560'
## Warning: Expecting numeric in L5221 / R5221C12: got 'IUC 6320'
## Warning: Expecting numeric in L5222 / R5222C12: got 'IUC 6510'
## Warning: Expecting numeric in L5223 / R5223C12: got 'IUC 6510'
## Warning: Expecting numeric in L5224 / R5224C12: got 'IUC 6560'
## Warning: Expecting numeric in L5225 / R5225C12: got 'IUC 6550'
## Warning: Expecting numeric in L5226 / R5226C12: got 'IUC 6520'
## Warning: Expecting numeric in L5227 / R5227C12: got 'IUC 6510'
## Warning: Expecting numeric in L5228 / R5228C12: got 'IUC 6530'
## Warning: Expecting numeric in L5229 / R5229C12: got 'IUC 6530'
## Warning: Expecting numeric in L5230 / R5230C12: got 'IUC 6560'
## Warning: Expecting numeric in L5231 / R5231C12: got 'IUC 6510'
## Warning: Expecting numeric in L5232 / R5232C12: got 'IUC 6560'
## Warning: Expecting numeric in L5233 / R5233C12: got 'IUC 6550'
## Warning: Expecting numeric in L5234 / R5234C12: got 'IUC 6510'
## Warning: Expecting numeric in L5235 / R5235C12: got 'IUC 6560'
## Warning: Expecting numeric in L5236 / R5236C12: got 'IUC 6510'
## Warning: Expecting numeric in L5237 / R5237C12: got 'IUC 6520'
## Warning: Expecting numeric in L5238 / R5238C12: got 'IUC 6550'
## Warning: Expecting numeric in L5239 / R5239C12: got 'IUC 6560'
## Warning: Expecting numeric in L5240 / R5240C12: got 'IUC 6550'
## Warning: Expecting numeric in L5241 / R5241C12: got 'IUC 6530'
## Warning: Expecting numeric in L5242 / R5242C12: got 'IUC 6560'
## Warning: Expecting numeric in L5243 / R5243C12: got 'IUC 6550'
## Warning: Expecting numeric in L5244 / R5244C12: got 'IUC 6550'
## Warning: Expecting numeric in L5245 / R5245C12: got 'IUC 6510'
## Warning: Expecting numeric in L5246 / R5246C12: got 'IUC 6520'
## Warning: Expecting numeric in L5247 / R5247C12: got 'IUC 6560'
## Warning: Expecting numeric in L5248 / R5248C12: got 'IUC 6520'
## Warning: Expecting numeric in L5249 / R5249C12: got 'IUC 6550'
## Warning: Expecting numeric in L5250 / R5250C12: got 'IUC 6530'
## Warning: Expecting numeric in L5251 / R5251C12: got 'IUC 6550'
## Warning: Expecting numeric in L5252 / R5252C12: got 'IUC 6510'
## Warning: Expecting numeric in L5253 / R5253C12: got 'IUC 7747'
## Warning: Expecting numeric in L5254 / R5254C12: got 'IUC 6550'
## Warning: Expecting numeric in L5255 / R5255C12: got 'IUC 6560'
## Warning: Expecting numeric in L5256 / R5256C12: got 'IUC 6560'
## Warning: Expecting numeric in L5257 / R5257C12: got 'IUC 3119'
## Warning: Expecting numeric in L5258 / R5258C12: got 'IUC 3119'
## Warning: Expecting numeric in L5259 / R5259C12: got 'IUC 6530'
## Warning: Expecting numeric in L5260 / R5260C12: got 'IUC 6530'
## Warning: Expecting numeric in L5261 / R5261C12: got 'IUC 6550'
## Warning: Expecting numeric in L5262 / R5262C12: got 'IUC 6510'
## Warning: Expecting numeric in L5263 / R5263C12: got 'IUC 6520'
## Warning: Expecting numeric in L5264 / R5264C12: got 'IUC 6560'
## Warning: Expecting numeric in L5265 / R5265C12: got 'IUC 6560'
## Warning: Expecting numeric in L5266 / R5266C12: got 'IUC 6510'
## Warning: Expecting numeric in L5267 / R5267C12: got 'IUC 6550'
## Warning: Expecting numeric in L5268 / R5268C12: got 'IUC 6550'
## Warning: Expecting numeric in L5269 / R5269C12: got 'IUC 6550'
## Warning: Expecting numeric in L5270 / R5270C12: got 'IUC 6510'
## Warning: Expecting numeric in L5271 / R5271C12: got 'IUC 6510'
## Warning: Expecting numeric in L5272 / R5272C12: got 'IUC 6550'
## Warning: Expecting numeric in L5273 / R5273C12: got 'IUC 6350'
## Warning: Expecting numeric in L5274 / R5274C12: got 'IUC 6550'
## Warning: Expecting numeric in L5275 / R5275C12: got 'IUC 6560'
## Warning: Expecting numeric in L5276 / R5276C12: got 'IUC 6510'
## Warning: Expecting numeric in L5277 / R5277C12: got 'IUC 6550'
## Warning: Expecting numeric in L5278 / R5278C12: got 'IUC 6510'
## Warning: Expecting numeric in L5279 / R5279C12: got 'IUC 6560'
## Warning: Expecting numeric in L5280 / R5280C12: got 'IUC 6560'
## Warning: Expecting numeric in L5281 / R5281C12: got 'IUC 6510'
## Warning: Expecting numeric in L5282 / R5282C12: got 'IUC 6560'
## Warning: Expecting numeric in L5283 / R5283C12: got 'IUC 6550'
## Warning: Expecting numeric in L5284 / R5284C12: got 'IUC 6560'
## Warning: Expecting numeric in L5285 / R5285C12: got 'IUC 6560'
## Warning: Expecting numeric in L5286 / R5286C12: got 'IUC 6510'
## Warning: Expecting numeric in L5287 / R5287C12: got 'IUC 6530'
## Warning: Expecting numeric in L5288 / R5288C12: got 'IUC 6560'
## Warning: Expecting numeric in L5289 / R5289C12: got 'IUC 6560'
## Warning: Expecting numeric in L5290 / R5290C12: got 'IUC 6510'
## Warning: Expecting numeric in L5291 / R5291C12: got 'IUC 6510'
## Warning: Expecting numeric in L5292 / R5292C12: got 'IUC 6560'
## Warning: Expecting numeric in L5293 / R5293C12: got 'IUC 6560'
## Warning: Expecting numeric in L5294 / R5294C12: got 'IUC 6560'
## Warning: Expecting numeric in L5295 / R5295C12: got 'IUC 6510'
## Warning: Expecting numeric in L5296 / R5296C12: got 'IUC 6510'
## Warning: Expecting numeric in L5297 / R5297C12: got 'IUC 6510'
## Warning: Expecting numeric in L5298 / R5298C12: got 'IUC 6510'
## Warning: Expecting numeric in L5299 / R5299C12: got 'IUC 6510'
## Warning: Expecting numeric in L5300 / R5300C12: got 'IUC 6560'
## Warning: Expecting numeric in L5301 / R5301C12: got 'IUC 6530'
## Warning: Expecting numeric in L5302 / R5302C12: got 'IUC 6551'
## Warning: Expecting numeric in L5303 / R5303C12: got 'IUC 6550'
## Warning: Expecting numeric in L5304 / R5304C12: got 'IUC 6560'
## Warning: Expecting numeric in L5305 / R5305C12: got 'IUC 6520'
## Warning: Expecting numeric in L5306 / R5306C12: got 'IUC 6520'
## Warning: Expecting numeric in L5307 / R5307C12: got 'IUC 6510'
## Warning: Expecting numeric in L5308 / R5308C12: got 'IUC 6510'
## Warning: Expecting numeric in L5309 / R5309C12: got 'IUC 6560'
## Warning: Expecting numeric in L5310 / R5310C12: got 'IUC 6560'
## Warning: Expecting numeric in L5311 / R5311C12: got 'IUC 6510'
## Warning: Expecting numeric in L5312 / R5312C12: got 'IUC 6550'
## Warning: Expecting numeric in L5313 / R5313C12: got 'IUC 6560'
## Warning: Expecting numeric in L5314 / R5314C12: got 'IUC 6560'
## Warning: Expecting numeric in L5315 / R5315C12: got 'IUC 6560'
## Warning: Expecting numeric in L5316 / R5316C12: got 'IUC 6510'
## Warning: Expecting numeric in L5317 / R5317C12: got 'IUC 6530'
## Warning: Expecting numeric in L5318 / R5318C12: got 'IUC 6510'
## Warning: Expecting numeric in L5319 / R5319C12: got 'IUC 6510'
## Warning: Expecting numeric in L5320 / R5320C12: got 'IUC 6510'
## Warning: Expecting numeric in L5321 / R5321C12: got 'IUC 6510'
## Warning: Expecting numeric in L5322 / R5322C12: got 'IUC 6510'
## Warning: Expecting numeric in L5323 / R5323C12: got 'IUC 6510'
## Warning: Expecting numeric in L5324 / R5324C12: got 'IUC 6520'
## Warning: Expecting numeric in L5325 / R5325C12: got 'IUC 6350'
## Warning: Expecting numeric in L5326 / R5326C12: got 'IUC 6562'
## Warning: Expecting numeric in L5327 / R5327C12: got 'IUC 6350'
## Warning: Expecting numeric in L5328 / R5328C12: got 'IUC 6510'
## Warning: Expecting numeric in L5329 / R5329C12: got 'IUC 6550'
## Warning: Expecting numeric in L5330 / R5330C12: got 'IUC 6510'
## Warning: Expecting numeric in L5331 / R5331C12: got 'IUC 6560'
## Warning: Expecting numeric in L5332 / R5332C12: got 'IUC 6550'
## Warning: Expecting numeric in L5333 / R5333C12: got 'IUC 6510'
## Warning: Expecting numeric in L5334 / R5334C12: got 'IUC 6560'
## Warning: Expecting numeric in L5335 / R5335C12: got 'IUC 6510'
## Warning: Expecting numeric in L5336 / R5336C12: got 'IUC 6560'
## Warning: Expecting numeric in L5337 / R5337C12: got 'IUC 6350'
## Warning: Expecting numeric in L5338 / R5338C12: got 'IUC 6550'
## Warning: Expecting numeric in L5339 / R5339C12: got 'IUC 6510'
## Warning: Expecting numeric in L5340 / R5340C12: got 'IUC 6520'
## Warning: Expecting numeric in L5341 / R5341C12: got 'IUC 6510'
## Warning: Expecting numeric in L5342 / R5342C12: got 'IUC 6560'
## Warning: Expecting numeric in L5343 / R5343C12: got 'IUC 6550'
## Warning: Expecting numeric in L5344 / R5344C12: got 'IUC 1072'
## Warning: Expecting numeric in L5345 / R5345C12: got 'IUC 6560'
## Warning: Expecting numeric in L5346 / R5346C12: got 'IUC 6510'
## Warning: Expecting numeric in L5347 / R5347C12: got 'IUC 6550'
## Warning: Expecting numeric in L5348 / R5348C12: got 'IUC 6350'
## Warning: Expecting numeric in L5349 / R5349C12: got 'IUC 6510'
## Warning: Expecting numeric in L5350 / R5350C12: got 'IUC 6560'
## Warning: Expecting numeric in L5351 / R5351C12: got 'IUC 6520'
## Warning: Expecting numeric in L5352 / R5352C12: got 'IUC 6510'
## Warning: Expecting numeric in L5353 / R5353C12: got 'IUC 6560'
## Warning: Expecting numeric in L5354 / R5354C12: got 'IUC 6550'
## Warning: Expecting numeric in L5355 / R5355C12: got 'IUC 6560'
## Warning: Expecting numeric in L5356 / R5356C12: got 'IUC 6550'
## Warning: Expecting numeric in L5357 / R5357C12: got 'IUC 6510'
## Warning: Expecting numeric in L5358 / R5358C12: got 'IUC 6350'
## Warning: Expecting numeric in L5359 / R5359C12: got 'IUC 6510'
## Warning: Expecting numeric in L5360 / R5360C12: got 'IUC 6560'
## Warning: Expecting numeric in L5361 / R5361C12: got 'IUC 2023'
## Warning: Expecting numeric in L5362 / R5362C12: got 'IUC 6550'
## Warning: Expecting numeric in L5363 / R5363C12: got 'IUC 6520'
## Warning: Expecting numeric in L5364 / R5364C12: got 'IUC 6560'
## Warning: Expecting numeric in L5365 / R5365C12: got 'IUC 6550'
## Warning: Expecting numeric in L5366 / R5366C12: got 'IUC 2023'
## Warning: Expecting numeric in L5367 / R5367C12: got 'IUC 6530'
## Warning: Expecting numeric in L5368 / R5368C12: got 'IUC 6560'
## Warning: Expecting numeric in L5369 / R5369C12: got 'IUC 6550'
## Warning: Expecting numeric in L5370 / R5370C12: got 'IUC 6560'
## Warning: Expecting numeric in L5371 / R5371C12: got 'IUC 6520'
## Warning: Expecting numeric in L5372 / R5372C12: got 'IUC 6550'
## Warning: Expecting numeric in L5373 / R5373C12: got 'IUC 6560'
## Warning: Expecting numeric in L5374 / R5374C12: got 'IUC 6550'
## Warning: Expecting numeric in L5375 / R5375C12: got 'IUC 6560'
## Warning: Expecting numeric in L5376 / R5376C12: got 'IUC 6560'
## Warning: Expecting numeric in L5377 / R5377C12: got 'IUC 6350'
## Warning: Expecting numeric in L5378 / R5378C12: got 'IUC 6510'
## Warning: Expecting numeric in L5379 / R5379C12: got 'IUC 6510'
## Warning: Expecting numeric in L5380 / R5380C12: got 'IUC 6510'
## Warning: Expecting numeric in L5381 / R5381C12: got 'IUC 6510'
## Warning: Expecting numeric in L5382 / R5382C12: got 'IUC 6350'
## Warning: Expecting numeric in L5383 / R5383C12: got 'IUC 6510'
## Warning: Expecting numeric in L5384 / R5384C12: got 'IUC 6510'
## Warning: Expecting numeric in L5385 / R5385C12: got 'IUC 6550'
## Warning: Expecting numeric in L5386 / R5386C12: got 'IUC 6530'
## Warning: Expecting numeric in L5387 / R5387C12: got 'IUC 6560'
## Warning: Expecting numeric in L5388 / R5388C12: got 'IUC 6560'
## Warning: Expecting numeric in L5389 / R5389C12: got 'IUC 6350'
## Warning: Expecting numeric in L5390 / R5390C12: got 'IUC 6520'
## Warning: Expecting numeric in L5391 / R5391C12: got 'IUC 6550'
## Warning: Expecting numeric in L5392 / R5392C12: got 'IUC 6510'
## Warning: Expecting numeric in L5393 / R5393C12: got 'IUC 6550'
## Warning: Expecting numeric in L5394 / R5394C12: got 'IUC 6510'
## Warning: Expecting numeric in L5395 / R5395C12: got 'IUC 6560'
## Warning: Expecting numeric in L5396 / R5396C12: got 'IUC 6560'
## Warning: Expecting numeric in L5397 / R5397C12: got 'IUC 6530'
## Warning: Expecting numeric in L5398 / R5398C12: got 'IUC 6560'
## Warning: Expecting numeric in L5399 / R5399C12: got 'IUC 6560'
## Warning: Expecting numeric in L5400 / R5400C12: got 'IUC 6520'
## Warning: Expecting numeric in L5401 / R5401C12: got 'IUC 6510'
## Warning: Expecting numeric in L5402 / R5402C12: got 'IUC 6530'
## Warning: Expecting numeric in L5403 / R5403C12: got 'IUC 6550'
## Warning: Expecting numeric in L5404 / R5404C12: got 'IUC 6550'
## Warning: Expecting numeric in L5405 / R5405C12: got 'IUC 6510'
## Warning: Expecting numeric in L5406 / R5406C12: got 'IUC 6510'
## Warning: Expecting numeric in L5407 / R5407C12: got 'IUC 6560'
## Warning: Expecting numeric in L5408 / R5408C12: got 'IUC 6560'
## Warning: Expecting numeric in L5409 / R5409C12: got 'IUC 6530'
## Warning: Expecting numeric in L5410 / R5410C12: got 'IUC 6550'
## Warning: Expecting numeric in L5411 / R5411C12: got 'IUC 6550'
## Warning: Expecting numeric in L5412 / R5412C12: got 'IUC 6560'
## Warning: Expecting numeric in L5413 / R5413C12: got 'IUC 6530'
## Warning: Expecting numeric in L5414 / R5414C12: got 'IUC 6562'
## Warning: Expecting numeric in L5415 / R5415C12: got 'IUC 6560'
## Warning: Expecting numeric in L5416 / R5416C12: got 'IUC 6560'
## Warning: Expecting numeric in L5417 / R5417C12: got 'IUC 6560'
## Warning: Expecting numeric in L5418 / R5418C12: got 'IUC 6560'
## Warning: Expecting numeric in L5419 / R5419C12: got 'IUC 6530'
## Warning: Expecting numeric in L5420 / R5420C12: got 'IUC 6550'
## Warning: Expecting numeric in L5421 / R5421C12: got 'IUC 6560'
## Warning: Expecting numeric in L5422 / R5422C12: got 'IUC 6530'
## Warning: Expecting numeric in L5423 / R5423C12: got 'IUC 6510'
## Warning: Expecting numeric in L5424 / R5424C12: got 'IUC 6550'
## Warning: Expecting numeric in L5425 / R5425C12: got 'IUC 6350'
## Warning: Expecting numeric in L5426 / R5426C12: got 'IUC 6560'
## Warning: Expecting numeric in L5427 / R5427C12: got 'IUC 6510'
## Warning: Expecting numeric in L5428 / R5428C12: got 'IUC 6560'
## Warning: Expecting numeric in L5429 / R5429C12: got 'IUC 6550'
## Warning: Expecting numeric in L5430 / R5430C12: got 'IUC 6560'
## Warning: Expecting numeric in L5431 / R5431C12: got 'IUC 6350'
## Warning: Expecting numeric in L5432 / R5432C12: got 'IUC 6520'
## Warning: Expecting numeric in L5433 / R5433C12: got 'IUC 6350'
## Warning: Expecting numeric in L5434 / R5434C12: got 'IUC 3119'
## Warning: Expecting numeric in L5435 / R5435C12: got 'IUC 6520'
## Warning: Expecting numeric in L5436 / R5436C12: got 'IUC 6560'
## Warning: Expecting numeric in L5437 / R5437C12: got 'IUC 6560'
## Warning: Expecting numeric in L5438 / R5438C12: got 'IUC 6560'
## Warning: Expecting numeric in L5439 / R5439C12: got 'IUC 6510'
## Warning: Expecting numeric in L5440 / R5440C12: got 'IUC 6560'
## Warning: Expecting numeric in L5441 / R5441C12: got 'IUC 6350'
## Warning: Expecting numeric in L5442 / R5442C12: got 'IUC 6510'
## Warning: Expecting numeric in L5443 / R5443C12: got 'IUC 6520'
## Warning: Expecting numeric in L5444 / R5444C12: got 'IUC 6530'
## Warning: Expecting numeric in L5445 / R5445C12: got 'IUC 6530'
## Warning: Expecting numeric in L5446 / R5446C12: got 'IUC 6560'
## Warning: Expecting numeric in L5447 / R5447C12: got 'IUC 6510'
## Warning: Expecting numeric in L5448 / R5448C12: got 'IUC 6560'
## Warning: Expecting numeric in L5449 / R5449C12: got 'IUC 6562'
## Warning: Expecting numeric in L5450 / R5450C12: got 'IUC 6560'
## Warning: Expecting numeric in L5451 / R5451C12: got 'IUC 6560'
## Warning: Expecting numeric in L5452 / R5452C12: got 'IUC 6560'
## Warning: Expecting numeric in L5453 / R5453C12: got 'IUC 6560'
## Warning: Expecting numeric in L5454 / R5454C12: got 'IUC 6560'
## Warning: Expecting numeric in L5455 / R5455C12: got 'IUC 6560'
## Warning: Expecting numeric in L5456 / R5456C12: got 'IUC 6560'
## Warning: Expecting numeric in L5457 / R5457C12: got 'IUC 6560'
## Warning: Expecting numeric in L5458 / R5458C12: got 'IUC 6520'
## Warning: Expecting numeric in L5459 / R5459C12: got 'IUC 6560'
## Warning: Expecting numeric in L5460 / R5460C12: got 'IUC 6560'
## Warning: Expecting numeric in L5461 / R5461C12: got 'IUC 6560'
## Warning: Expecting numeric in L5462 / R5462C12: got 'IUC 6550'
## Warning: Expecting numeric in L5463 / R5463C12: got 'IUC 6520'
## Warning: Expecting numeric in L5464 / R5464C12: got 'IUC 6530'
## Warning: Expecting numeric in L5465 / R5465C12: got 'IUC 6350'
## Warning: Expecting numeric in L5466 / R5466C12: got 'IUC 6550'
## Warning: Expecting numeric in L5467 / R5467C12: got 'IUC 6560'
## Warning: Expecting numeric in L5468 / R5468C12: got 'IUC 6550'
## Warning: Expecting numeric in L5469 / R5469C12: got 'IUC 6560'
## Warning: Expecting numeric in L5470 / R5470C12: got 'IUC 6560'
## Warning: Expecting numeric in L5471 / R5471C12: got 'IUC 6560'
## Warning: Expecting numeric in L5472 / R5472C12: got 'IUC 6550'
## Warning: Expecting numeric in L5473 / R5473C12: got 'IUC 6550'
## Warning: Expecting numeric in L5474 / R5474C12: got 'IUC 6550'
## Warning: Expecting numeric in L5475 / R5475C12: got 'IUC 6510'
## Warning: Expecting numeric in L5476 / R5476C12: got 'IUC 6560'
## Warning: Expecting numeric in L5477 / R5477C12: got 'IUC 6550'
## Warning: Expecting numeric in L5478 / R5478C12: got 'IUC 6560'
## Warning: Expecting numeric in L5479 / R5479C12: got 'IUC 6560'
## Warning: Expecting numeric in L5480 / R5480C12: got 'IUC 6560'
## Warning: Expecting numeric in L5481 / R5481C12: got 'IUC 6550'
## Warning: Expecting numeric in L5482 / R5482C12: got 'IUC 6550'
## Warning: Expecting numeric in L5483 / R5483C12: got 'IUC 6550'
## Warning: Expecting numeric in L5484 / R5484C12: got 'IUC 6550'
## Warning: Expecting numeric in L5485 / R5485C12: got 'IUC 6530'
## Warning: Expecting numeric in L5486 / R5486C12: got 'IUC 6520'
## Warning: Expecting numeric in L5487 / R5487C12: got 'IUC 6560'
## Warning: Expecting numeric in L5488 / R5488C12: got 'IUC 6560'
## Warning: Expecting numeric in L5489 / R5489C12: got 'IUC 6560'
## Warning: Expecting numeric in L5490 / R5490C12: got 'IUC 6550'
## Warning: Expecting numeric in L5491 / R5491C12: got 'IUC 6560'
## Warning: Expecting numeric in L5492 / R5492C12: got 'IUC 2023'
## Warning: Expecting numeric in L5493 / R5493C12: got 'IUC 6550'
## Warning: Expecting numeric in L5494 / R5494C12: got 'IUC 6550'
## Warning: Expecting numeric in L5495 / R5495C12: got 'IUC 6560'
## Warning: Expecting numeric in L5496 / R5496C12: got 'IUC 6560'
## Warning: Expecting numeric in L5497 / R5497C12: got 'IUC 6520'
## Warning: Expecting numeric in L5498 / R5498C12: got 'IUC 6560'
## Warning: Expecting numeric in A5516 / R5516C1: got 'D000090771'
## Warning: Expecting numeric in AH5516 / R5516C34: got 'D000090771'
## Warning: Expecting numeric in A5517 / R5517C1: got 'D000371281'
## Warning: Expecting numeric in AH5517 / R5517C34: got 'D000371281'
## Warning: Expecting numeric in A5518 / R5518C1: got 'D00151617'
## Warning: Expecting numeric in AH5518 / R5518C34: got 'D00151617'
## Warning: Expecting numeric in A5519 / R5519C1: got 'D002510777'
## Warning: Expecting numeric in AH5519 / R5519C34: got 'D002510777'
## Warning: Expecting numeric in A5520 / R5520C1: got 'D004009030'
## Warning: Expecting numeric in AH5520 / R5520C34: got 'D004009030'
## Warning: Expecting numeric in A5521 / R5521C1: got 'D016007075'
## Warning: Expecting numeric in AH5521 / R5521C34: got 'D016007075'
## Warning: Expecting numeric in A5522 / R5522C1: got 'D129406'
## Warning: Expecting numeric in AH5522 / R5522C34: got 'D129406'
## Warning: Expecting numeric in A5523 / R5523C1: got 'D144704'
## Warning: Expecting numeric in AH5523 / R5523C34: got 'D144704'
## Warning: Expecting numeric in A5524 / R5524C1: got 'D152912'
## Warning: Expecting numeric in AH5524 / R5524C34: got 'D152912'
## Warning: Expecting numeric in A5525 / R5525C1: got 'D158233'
## Warning: Expecting numeric in AH5525 / R5525C34: got 'D158233'
## Warning: Expecting numeric in A5526 / R5526C1: got 'D18659'
## Warning: Expecting numeric in AH5526 / R5526C34: got 'D18659'
## Warning: Expecting numeric in A5527 / R5527C1: got 'D23173'
## Warning: Expecting numeric in AH5527 / R5527C34: got 'D23173'
## Warning: Expecting numeric in A5528 / R5528C1: got 'D29759'
## Warning: Expecting numeric in AH5528 / R5528C34: got 'D29759'
## Warning: Expecting numeric in A5529 / R5529C1: got 'D349638'
## Warning: Expecting numeric in AH5529 / R5529C34: got 'D349638'
## Warning: Expecting numeric in A5530 / R5530C1: got 'D359549'
## Warning: Expecting numeric in AH5530 / R5530C34: got 'D359549'
## Warning: Expecting numeric in A5531 / R5531C1: got 'D362753'
## Warning: Expecting numeric in AH5531 / R5531C34: got 'D362753'
## Warning: Expecting numeric in A5532 / R5532C1: got 'D366919'
## Warning: Expecting numeric in AH5532 / R5532C34: got 'D366919'
## Warning: Expecting numeric in A5533 / R5533C1: got 'D374881'
## Warning: Expecting numeric in AH5533 / R5533C34: got 'D374881'
## Warning: Expecting numeric in A5534 / R5534C1: got 'D380886'
## Warning: Expecting numeric in AH5534 / R5534C34: got 'D380886'
## Warning: Expecting numeric in A5535 / R5535C1: got 'D391580'
## Warning: Expecting numeric in AH5535 / R5535C34: got 'D391580'
## Warning: Expecting numeric in A5536 / R5536C1: got 'D396386'
## Warning: Expecting numeric in AH5536 / R5536C34: got 'D396386'
## Warning: Expecting numeric in A5537 / R5537C1: got 'D403685'
## Warning: Expecting numeric in AH5537 / R5537C34: got 'D403685'
## Warning: Expecting numeric in A5538 / R5538C1: got 'D428875'
## Warning: Expecting numeric in AH5538 / R5538C34: got 'D428875'
## Warning: Expecting numeric in A5539 / R5539C1: got 'D434510'
## Warning: Expecting numeric in AH5539 / R5539C34: got 'D434510'
## Warning: Expecting numeric in A5540 / R5540C1: got 'D450602'
## Warning: Expecting numeric in AH5540 / R5540C34: got 'D450602'
## Warning: Expecting numeric in A5541 / R5541C1: got 'D46842'
## Warning: Expecting numeric in AH5541 / R5541C34: got 'D46842'
## Warning: Expecting numeric in A5542 / R5542C1: got 'D556716'
## Warning: Expecting numeric in A5543 / R5543C1: got 'D572038'
## Warning: Expecting numeric in A5544 / R5544C1: got 'D605285'
## Warning: Expecting numeric in A5545 / R5545C1: got 'D7328453'
## Warning: Expecting numeric in AH5545 / R5545C34: got 'D7328453'
## Warning: Expecting numeric in A5546 / R5546C1: got 'D73434'
## Warning: Expecting numeric in AH5546 / R5546C34: got 'D73434'
## Warning: Expecting numeric in A5547 / R5547C1: got 'D74311'
## Warning: Expecting numeric in A5548 / R5548C1: got 'D88097'
## Warning: Expecting numeric in AH5548 / R5548C34: got 'D88097'
## Warning: Expecting numeric in A5549 / R5549C1: got 'SJL0'
## Warning: Expecting numeric in A5550 / R5550C1: got 'SJL146050238113400'
## Warning: Expecting numeric in A5551 / R5551C1: got 'SJL1530792802852'
## Warning: Expecting numeric in A5552 / R5552C1: got 'SJL155117867003400'
## Warning: Expecting numeric in A5553 / R5553C1: got 'SJL156063854504800'
## Warning: Expecting numeric in A5554 / R5554C1: got 'sjl161077505134400'
## Warning: Expecting numeric in A5555 / R5555C1: got 'SJL253117655262200'
## Warning: Expecting numeric in A5556 / R5556C1: got 'SJL655448884'
## New names:
## • `nom jeune fille` -> `nom jeune fille...19`
## • `date_os` -> `date_os...54`
## • `nom jeune fille` -> `nom jeune fille...58`
## • `date_os` -> `date_os...80`
## • `` -> `...98`
##recodage des variables et bases de données le cas échéant----
cbnpc<-filter(recap_survies_v2026034, c(eligible_v2=="oui" ))
##renommer des variables pour présentation dans les tableaux de résultats
library(labelled)
##création de variables à plusieurs catégorie selon valeurs variable continue
cbnpc$old70<-ifelse(cbnpc$age_initiation>70, 1, 0)
cbnpc$maigres<-ifelse(cbnpc$imc<18.5, 1, 0)
cbnpc$surpoids<-ifelse(cbnpc$imc>25, 1, 0)
cbnpc$obeses<-ifelse(cbnpc$imc>30, 1, 0)
cbnpc$young57<-ifelse(cbnpc$age_initiation<57, 1, 0)
##tableau descriptif population globales ----
tbl_summary(
cbnpc, include = c("age_initiation", "sexe.cat", "protocole_generique_initiation",
"imc","immuno", "avastin"),
digits=all_categorical()~ c(0,1)
)
| Characteristic |
N = 2,387 |
| age_initiation |
63 (57, 70) |
| sexe.cat |
|
| F |
846 (35.4%) |
| H |
1,541 (64.6%) |
| protocole_generique_initiation |
|
| cemiplimab |
8 (0.3%) |
| ipi_nivo |
10 (0.4%) |
| pembro_abemaciclib |
2 (0.1%) |
| pembrolizumab |
180 (7.5%) |
| platine_alimta |
783 (32.8%) |
| platine_alimta_atezo |
2 (0.1%) |
| platine_alimta_avastin |
133 (5.6%) |
| platine_alimta_avastin_atezo |
8 (0.3%) |
| platine_alimta_nivolumab |
6 (0.3%) |
| platine_alimta_pembro |
346 (14.5%) |
| platine_docetaxel |
64 (2.7%) |
| platine_gemcitabine |
79 (3.3%) |
| platine_gemcitabine_avastin |
6 (0.3%) |
| platine_gemcitabine_nivolumab |
2 (0.1%) |
| platine_taxol |
255 (10.7%) |
| platine_taxol_atezo |
8 (0.3%) |
| platine_taxol_avastin |
12 (0.5%) |
| platine_taxol_nivolumab |
2 (0.1%) |
| platine_taxol_pembro |
60 (2.5%) |
| platine_vinorelbine |
420 (17.6%) |
| taxol_avastin_atezo |
1 (0.0%) |
| imc |
22.9 (20.1, 25.9) |
| immuno |
1,188 (49.8%) |
| avastin |
299 (12.5%) |
##tableau descriptif population globales par année----
tbl_summary(
cbnpc, include = c("age_initiation", "sexe.cat", "protocole_generique_initiation",
"imc","immuno", "avastin"),
by="annee",
digits=all_categorical()~ c(0,1)
)%>%
add_p()
## There was an error in 'add_p()/add_difference()' for variable 'protocole_generique_initiation', p-value omitted:
## Error in stats::fisher.test(c("platine_vinorelbine", "platine_vinorelbine", : FEXACT error 5.
## The hash table key cannot be computed because the largest key
## is larger than the largest representable int.
## The algorithm cannot proceed.
## Reduce the workspace, consider using 'simulate.p.value=TRUE' or another algorithm.
| Characteristic |
2010, N = 123 |
2011, N = 121 |
2012, N = 111 |
2013, N = 106 |
2014, N = 164 |
2015, N = 161 |
2016, N = 171 |
2017, N = 180 |
2018, N = 196 |
2019, N = 224 |
2020, N = 201 |
2021, N = 196 |
2022, N = 196 |
2023, N = 161 |
2024, N = 76 |
p-value |
| age_initiation |
59 (54, 66) |
60 (54, 68) |
61 (54, 68) |
60 (55, 68) |
64 (57, 71) |
62 (56, 67) |
63 (57, 69) |
63 (57, 69) |
64 (57, 72) |
65 (59, 71) |
63 (56, 70) |
64 (58, 71) |
64 (58, 72) |
65 (59, 72) |
65 (54, 71) |
<0.001 |
| sexe.cat |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0.10 |
| F |
43 (35.0%) |
36 (29.8%) |
35 (31.5%) |
33 (31.1%) |
49 (29.9%) |
46 (28.6%) |
58 (33.9%) |
72 (40.0%) |
71 (36.2%) |
98 (43.8%) |
77 (38.3%) |
69 (35.2%) |
79 (40.3%) |
57 (35.4%) |
23 (30.3%) |
|
| H |
80 (65.0%) |
85 (70.2%) |
76 (68.5%) |
73 (68.9%) |
115 (70.1%) |
115 (71.4%) |
113 (66.1%) |
108 (60.0%) |
125 (63.8%) |
126 (56.2%) |
124 (61.7%) |
127 (64.8%) |
117 (59.7%) |
104 (64.6%) |
53 (69.7%) |
|
| protocole_generique_initiation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| cemiplimab |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
6 (3.7%) |
2 (2.6%) |
|
| ipi_nivo |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
1 (0.5%) |
8 (3.6%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| pembro_abemaciclib |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
2 (1.1%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| pembrolizumab |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
3 (1.7%) |
37 (18.9%) |
48 (21.4%) |
28 (13.9%) |
19 (9.7%) |
21 (10.7%) |
16 (9.9%) |
8 (10.5%) |
|
| platine_alimta |
24 (19.5%) |
53 (43.8%) |
55 (49.5%) |
57 (53.8%) |
75 (45.7%) |
73 (45.3%) |
80 (46.8%) |
93 (51.7%) |
89 (45.4%) |
89 (39.7%) |
25 (12.4%) |
30 (15.3%) |
26 (13.3%) |
12 (7.5%) |
2 (2.6%) |
|
| platine_alimta_atezo |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
2 (1.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_alimta_avastin |
7 (5.7%) |
5 (4.1%) |
2 (1.8%) |
8 (7.5%) |
20 (12.2%) |
21 (13.0%) |
17 (9.9%) |
12 (6.7%) |
15 (7.7%) |
13 (5.8%) |
3 (1.5%) |
6 (3.1%) |
2 (1.0%) |
1 (0.6%) |
1 (1.3%) |
|
| platine_alimta_avastin_atezo |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
7 (3.5%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_alimta_nivolumab |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
1 (0.5%) |
2 (1.0%) |
3 (1.9%) |
0 (0.0%) |
|
| platine_alimta_pembro |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
10 (4.5%) |
72 (35.8%) |
75 (38.3%) |
91 (46.4%) |
57 (35.4%) |
41 (53.9%) |
|
| platine_docetaxel |
25 (20.3%) |
23 (19.0%) |
3 (2.7%) |
2 (1.9%) |
0 (0.0%) |
4 (2.5%) |
4 (2.3%) |
1 (0.6%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_gemcitabine |
12 (9.8%) |
4 (3.3%) |
17 (15.3%) |
11 (10.4%) |
7 (4.3%) |
6 (3.7%) |
4 (2.3%) |
4 (2.2%) |
3 (1.5%) |
7 (3.1%) |
2 (1.0%) |
1 (0.5%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_gemcitabine_avastin |
3 (2.4%) |
1 (0.8%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
2 (1.2%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_gemcitabine_nivolumab |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
1 (0.5%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_taxol |
11 (8.9%) |
16 (13.2%) |
16 (14.4%) |
8 (7.5%) |
22 (13.4%) |
14 (8.7%) |
17 (9.9%) |
10 (5.6%) |
12 (6.1%) |
14 (6.2%) |
20 (10.0%) |
34 (17.3%) |
27 (13.8%) |
24 (14.9%) |
10 (13.2%) |
|
| platine_taxol_atezo |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
4 (2.0%) |
1 (0.5%) |
2 (1.0%) |
1 (0.6%) |
0 (0.0%) |
|
| platine_taxol_avastin |
4 (3.3%) |
6 (5.0%) |
2 (1.8%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
|
| platine_taxol_nivolumab |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
2 (1.2%) |
0 (0.0%) |
|
| platine_taxol_pembro |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
7 (3.5%) |
10 (5.1%) |
14 (7.1%) |
24 (14.9%) |
5 (6.6%) |
|
| platine_vinorelbine |
37 (30.1%) |
13 (10.7%) |
16 (14.4%) |
20 (18.9%) |
40 (24.4%) |
41 (25.5%) |
49 (28.7%) |
55 (30.6%) |
37 (18.9%) |
35 (15.6%) |
30 (14.9%) |
17 (8.7%) |
9 (4.6%) |
15 (9.3%) |
6 (7.9%) |
|
| taxol_avastin_atezo |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
0 (0.0%) |
1 (1.3%) |
|
| imc |
23.1 (20.3, 25.6) |
23.1 (20.2, 25.7) |
22.7 (19.6, 26.0) |
24.2 (20.0, 26.8) |
22.6 (20.4, 25.2) |
22.7 (20.1, 25.5) |
22.7 (20.1, 26.0) |
23.0 (19.8, 26.0) |
23.1 (20.1, 26.1) |
23.2 (20.5, 26.8) |
22.9 (20.3, 25.7) |
23.1 (20.7, 26.0) |
22.8 (19.6, 25.9) |
22.4 (19.8, 25.0) |
22.7 (19.6, 25.3) |
0.8 |
| immuno |
1 (0.8%) |
4 (3.3%) |
5 (4.5%) |
10 (9.4%) |
24 (14.6%) |
72 (44.7%) |
84 (49.1%) |
96 (53.3%) |
115 (58.7%) |
146 (65.2%) |
150 (74.6%) |
139 (70.9%) |
157 (80.1%) |
124 (77.0%) |
61 (80.3%) |
<0.001 |
| avastin |
19 (15.4%) |
18 (14.9%) |
10 (9.0%) |
12 (11.3%) |
21 (12.8%) |
29 (18.0%) |
18 (10.5%) |
25 (13.9%) |
23 (11.7%) |
28 (12.5%) |
30 (14.9%) |
21 (10.7%) |
22 (11.2%) |
18 (11.2%) |
5 (6.6%) |
0.5 |
#Courbe de Kaplan Meier population globale----
km_os<-survfit(Surv(cbnpc$os, cbnpc$evt_os)~1)
km_os
## Call: survfit(formula = Surv(cbnpc$os, cbnpc$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 2387 2007 12.7 11.9 13.9
ggsurvplot(km_os, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
#Courbe de Kaplan Meier selon tt par avastin----
km_os_avastin<-survfit(Surv(os, evt_os)~avastin, data=cbnpc)
km_os_avastin
## Call: survfit(formula = Surv(os, evt_os) ~ avastin, data = cbnpc)
##
## n events median 0.95LCL 0.95UCL
## avastin=0 2088 1745 11.4 10.5 12.5
## avastin=1 299 262 21.7 19.4 24.9
ggsurvplot(km_os_avastin, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
#Courbe de Kaplan Meier selon tt par immuno----
km_os_immuno<-survfit(Surv(os, evt_os)~immuno, data=cbnpc)
km_os_immuno
## Call: survfit(formula = Surv(os, evt_os) ~ immuno, data = cbnpc)
##
## n events median 0.95LCL 0.95UCL
## immuno=0 1199 1073 8.73 8.07 9.4
## immuno=1 1188 934 18.13 16.73 19.7
ggsurvplot(km_os_immuno, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
#Courbe de Kaplan Meier selon tt initial----
km_os_tt_initial<-survfit(Surv(os, evt_os)~tt_initial, data=cbnpc)
km_os_tt_initial
## Call: survfit(formula = Surv(os, evt_os) ~ tt_initial, data = cbnpc)
##
## n events median 0.95LCL 0.95UCL
## tt_initial=chimio 1610 1444 11.03 10.13 12.2
## tt_initial=chimio_immuno 435 295 18.30 15.47 20.4
## tt_initial=chirurgie 20 17 20.65 12.53 48.0
## tt_initial=double_immuno 10 9 8.43 2.43 NA
## tt_initial=immuno 190 143 11.37 9.00 17.1
## tt_initial=radio_chimio 122 99 24.03 21.60 27.6
ggsurvplot(km_os_tt_initial, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
#Courbe de Kaplan Meier selon année initiation----
km_os_annee<-survfit(Surv(os, evt_os)~annee, data=cbnpc)
ggsurvplot(km_os_annee, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
#Courbe de Kaplan Meier selon année initiation----
km_os_annee<-survfit(Surv(os, evt_os)~annee, data=cbnpc)
ggsurvplot(km_os_annee, data = cbnpc,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
##population selon années
####2010
cbnpc2010<-filter(cbnpc, c(annee==2010 ))
km_2010<-survfit(Surv(cbnpc2010$os, cbnpc2010$evt_os)~1)
km_2010
## Call: survfit(formula = Surv(cbnpc2010$os, cbnpc2010$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 123 118 12.3 10.1 17.2
ggsurvplot(km_2010, data = cbnpc2010,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2012
cbnpc2012<-filter(cbnpc, c(annee==2012 ))
km_2012<-survfit(Surv(cbnpc2012$os, cbnpc2012$evt_os)~1)
km_2012
## Call: survfit(formula = Surv(cbnpc2012$os, cbnpc2012$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 111 108 10.8 8.6 14.9
ggsurvplot(km_2012, data = cbnpc2012,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2014
cbnpc2014<-filter(cbnpc, c(annee==2014 ))
km_2014<-survfit(Surv(cbnpc2014$os, cbnpc2014$evt_os)~1)
km_2014
## Call: survfit(formula = Surv(cbnpc2014$os, cbnpc2014$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 164 154 9.8 7.9 13.9
ggsurvplot(km_2014, data = cbnpc2014,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2016
cbnpc2016<-filter(cbnpc, c(annee==2016 ))
km_2016<-survfit(Surv(cbnpc2016$os, cbnpc2016$evt_os)~1)
km_2016
## Call: survfit(formula = Surv(cbnpc2016$os, cbnpc2016$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 171 161 11.2 8.6 14.3
ggsurvplot(km_2016, data = cbnpc2016,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2018
cbnpc2018<-filter(cbnpc, c(annee==2018 ))
km_2018<-survfit(Surv(cbnpc2018$os, cbnpc2018$evt_os)~1)
km_2018
## Call: survfit(formula = Surv(cbnpc2018$os, cbnpc2018$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 196 162 13.4 9.7 17.7
ggsurvplot(km_2018, data = cbnpc2018,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2020
cbnpc2020<-filter(cbnpc, c(annee==2020 ))
km_2020<-survfit(Surv(cbnpc2020$os, cbnpc2020$evt_os)~1)
km_2020
## Call: survfit(formula = Surv(cbnpc2020$os, cbnpc2020$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 201 155 18.4 13.9 22.2
ggsurvplot(km_2020, data = cbnpc2020,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2022
cbnpc2022<-filter(cbnpc, c(annee==2022 ))
km_2022<-survfit(Surv(cbnpc2022$os, cbnpc2022$evt_os)~1)
km_2022
## Call: survfit(formula = Surv(cbnpc2022$os, cbnpc2022$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 196 136 17.4 13.7 21.2
ggsurvplot(km_2022, data = cbnpc2022,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####2023
cbnpc2023<-filter(cbnpc, c(annee==2023 ))
km_2023<-survfit(Surv(cbnpc2023$os, cbnpc2023$evt_os)~1)
km_2023
## Call: survfit(formula = Surv(cbnpc2023$os, cbnpc2023$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 161 117 12.4 8.87 16.2
ggsurvplot(km_2023, data = cbnpc2023,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
tbl_summary(
cbnpc2023, include = c("age_initiation", "sexe.cat", "protocole_generique_initiation",
"imc","immuno", "avastin"),
digits=all_categorical()~ c(0,1)
)
| Characteristic |
N = 161 |
| age_initiation |
65 (59, 72) |
| sexe.cat |
|
| F |
57 (35.4%) |
| H |
104 (64.6%) |
| protocole_generique_initiation |
|
| cemiplimab |
6 (3.7%) |
| pembrolizumab |
16 (9.9%) |
| platine_alimta |
12 (7.5%) |
| platine_alimta_avastin |
1 (0.6%) |
| platine_alimta_nivolumab |
3 (1.9%) |
| platine_alimta_pembro |
57 (35.4%) |
| platine_taxol |
24 (14.9%) |
| platine_taxol_atezo |
1 (0.6%) |
| platine_taxol_nivolumab |
2 (1.2%) |
| platine_taxol_pembro |
24 (14.9%) |
| platine_vinorelbine |
15 (9.3%) |
| imc |
22.4 (19.8, 25.0) |
| immuno |
124 (77.0%) |
| avastin |
18 (11.2%) |
tbl_summary(
cbnpc2022, include = c("age_initiation", "sexe.cat", "protocole_generique_initiation",
"imc","immuno", "avastin"),
digits=all_categorical()~ c(0,1)
)
| Characteristic |
N = 196 |
| age_initiation |
64 (58, 72) |
| sexe.cat |
|
| F |
79 (40.3%) |
| H |
117 (59.7%) |
| protocole_generique_initiation |
|
| pembrolizumab |
21 (10.7%) |
| platine_alimta |
26 (13.3%) |
| platine_alimta_avastin |
2 (1.0%) |
| platine_alimta_nivolumab |
2 (1.0%) |
| platine_alimta_pembro |
91 (46.4%) |
| platine_gemcitabine |
1 (0.5%) |
| platine_gemcitabine_nivolumab |
1 (0.5%) |
| platine_taxol |
27 (13.8%) |
| platine_taxol_atezo |
2 (1.0%) |
| platine_taxol_pembro |
14 (7.1%) |
| platine_vinorelbine |
9 (4.6%) |
| imc |
22.8 (19.6, 25.9) |
| immuno |
157 (80.1%) |
| avastin |
22 (11.2%) |
####2024
cbnpc2024<-filter(cbnpc, c(annee==2024 ))
km_2024<-survfit(Surv(cbnpc2024$os, cbnpc2024$evt_os)~1)
km_2024
## Call: survfit(formula = Surv(cbnpc2024$os, cbnpc2024$evt_os) ~ 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 76 38 18.4 12.4 NA
ggsurvplot(km_2024, data = cbnpc2024,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
##population selon tt intial
####chimio
cbnpcchimio<-filter(cbnpc, c(tt_initial=="chimio" ))
km_chimio<-survfit(Surv(cbnpcchimio$os, cbnpcchimio$evt_os)~1)
km_chimio
## Call: survfit(formula = Surv(cbnpcchimio$os, cbnpcchimio$evt_os) ~
## 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 1610 1444 11 10.1 12.2
ggsurvplot(km_chimio, data = cbnpcchimio,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####immuno
cbnpcimmuno<-filter(cbnpc, c(tt_initial=="immuno" ))
km_immuno<-survfit(Surv(cbnpcimmuno$os, cbnpcimmuno$evt_os)~1)
km_immuno
## Call: survfit(formula = Surv(cbnpcimmuno$os, cbnpcimmuno$evt_os) ~
## 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 190 143 11.4 9 17.1
ggsurvplot(km_immuno, data = cbnpcimmuno,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
####chimio_immuno
cbnpcchimioimmuno<-filter(cbnpc, c(tt_initial=="chimio_immuno" ))
km_chimio_immuno<-survfit(Surv(cbnpcchimioimmuno$os, cbnpcchimioimmuno$evt_os)~1)
km_chimio_immuno
## Call: survfit(formula = Surv(cbnpcchimioimmuno$os, cbnpcchimioimmuno$evt_os) ~
## 1)
##
## n events median 0.95LCL 0.95UCL
## [1,] 435 295 18.3 15.5 20.4
ggsurvplot(km_chimio_immuno, data = cbnpcchimioimmuno,
risk.table=TRUE,
surv.scale="percent",
break.time.by=3,
surv.median.line = "hv"
)
##modèle de cox os
##analyses univariée tableau récap plusieurs variables
tbl_uvregression(
cbnpc,
method = coxph,
y = Surv(os, evt_os),
exponentiate = TRUE,
include = c(age_initiation, old70, young57, maigres, surpoids, obeses, sexe.cat, imc, immuno, avastin, tt_initial),
pvalue_fun = scales::label_pvalue(accuracy = .001)
)
| Characteristic |
N |
HR |
95% CI |
p-value |
| immuno |
2,387 |
0.64 |
0.59, 0.70 |
<0.001 |
| avastin |
2,387 |
0.78 |
0.69, 0.89 |
<0.001 |
| age_initiation |
2,387 |
1.00 |
1.00, 1.01 |
0.034 |
| sexe.cat |
2,387 |
|
|
|
| F |
|
— |
— |
|
| H |
|
1.13 |
1.04, 1.24 |
0.007 |
| imc |
2,387 |
0.96 |
0.95, 0.97 |
<0.001 |
| tt_initial |
2,387 |
|
|
|
| chimio |
|
— |
— |
|
| chimio_immuno |
|
0.69 |
0.61, 0.79 |
<0.001 |
| chirurgie |
|
0.72 |
0.44, 1.16 |
0.173 |
| double_immuno |
|
1.25 |
0.65, 2.41 |
0.499 |
| immuno |
|
0.83 |
0.70, 0.99 |
0.037 |
| radio_chimio |
|
0.66 |
0.54, 0.80 |
<0.001 |
| old70 |
2,387 |
1.07 |
0.96, 1.18 |
0.215 |
| maigres |
2,387 |
1.63 |
1.43, 1.85 |
<0.001 |
| surpoids |
2,387 |
0.77 |
0.70, 0.84 |
<0.001 |
| obeses |
2,387 |
0.76 |
0.64, 0.90 |
0.001 |
| young57 |
2,387 |
0.94 |
0.85, 1.04 |
0.200 |
##analyse multivariée avec résultats dans tableau
modsurv<-coxph(Surv(os, evt_os)~sexe.cat+maigres +tt_initial, data=cbnpc)
modsurv%>%tbl_regression(
exponentiate = TRUE,pvalue_fun = scales::label_pvalue(accuracy = .001)
)
| Characteristic |
HR |
95% CI |
p-value |
| sexe.cat |
|
|
|
| F |
— |
— |
|
| H |
1.19 |
1.08, 1.31 |
<0.001 |
| maigres |
1.72 |
1.51, 1.96 |
<0.001 |
| tt_initial |
|
|
|
| chimio |
— |
— |
|
| chimio_immuno |
0.68 |
0.60, 0.77 |
<0.001 |
| chirurgie |
0.76 |
0.47, 1.23 |
0.271 |
| double_immuno |
1.40 |
0.73, 2.70 |
0.313 |
| immuno |
0.81 |
0.69, 0.97 |
0.020 |
| radio_chimio |
0.66 |
0.54, 0.81 |
<0.001 |