Demographics
|
|
Overall
|
|
n
|
32
|
|
Gender = Male (%)
|
19 (59.4)
|
|
YearGroup = >50 (%)
|
23 (71.9)
|
|
Ethnicity1 (%)
|
|
|
Asian
|
7 (21.9)
|
|
Black
|
1 ( 3.1)
|
|
Other
|
1 ( 3.1)
|
|
White
|
23 (71.9)
|
|
Site (%)
|
|
|
Right
|
21 (65.6)
|
|
Left
|
4 (12.5)
|
|
Rectum
|
4 (12.5)
|
|
Transverse
|
3 ( 9.4)
|
|
LynchSyndrome = Si (%)
|
2 ( 6.2)
|
|
Lymph.nodes = Si (%)
|
2 ( 6.2)
|
|
Lung.mets = Si (%)
|
4 (12.5)
|
|
Liver.mets = Si (%)
|
7 (21.9)
|
|
Bone.mets = Si (%)
|
0 ( 0.0)
|
|
Differentiation (%)
|
|
|
Mild
|
0 ( 0.0)
|
|
Moderate
|
21 (65.6)
|
|
Poor
|
11 (34.4)
|
|
Loss.MLH1 = Si (%)
|
23 (71.9)
|
|
Loss.MSH2 = Si (%)
|
7 (21.9)
|
|
Loss.MSH6 = Si (%)
|
7 (21.9)
|
|
Loss.PMS2 = Si (%)
|
25 (78.1)
|
|
BRAFmut (%)
|
|
|
No
|
17 (53.1)
|
|
Si
|
14 (43.8)
|
|
NA
|
1 ( 3.1)
|
|
BRAF.mut..specify. = NA (%)
|
18 (56.2)
|
|
KRASmut (%)
|
|
|
No
|
22 (68.8)
|
|
Si
|
9 (28.1)
|
|
NA
|
1 ( 3.1)
|
|
KRAS.mut..specify. (%)
|
|
|
A146W
|
1 ( 3.1)
|
|
G12D
|
2 ( 6.2)
|
|
G12D, A146W
|
1 ( 3.1)
|
|
G12D, G12R
|
2 ( 6.2)
|
|
G12W
|
1 ( 3.1)
|
|
G13D
|
2 ( 6.2)
|
|
NA
|
23 (71.9)
|
|
PIK3CAmut (%)
|
|
|
No
|
19 (59.4)
|
|
Si
|
12 (37.5)
|
|
NA
|
1 ( 3.1)
|
|
TP53mut (%)
|
|
|
No
|
24 (75.0)
|
|
Si
|
7 (21.9)
|
|
NA
|
1 ( 3.1)
|
|
CEA.dx.positive (%)
|
|
|
No
|
11 (34.4)
|
|
Si
|
14 (43.8)
|
|
NA
|
7 (21.9)
|
|
CA19.9.dx.positive (%)
|
|
|
No
|
7 (21.9)
|
|
Si
|
4 (12.5)
|
|
NA
|
21 (65.6)
|
|
Surgery = Si (%)
|
19 (59.4)
|
|
IO.Prior.Surgery (%)
|
|
|
No
|
16 (50.0)
|
|
Si
|
3 ( 9.4)
|
|
NA
|
13 (40.6)
|
|
Type.Surgery (%)
|
|
|
Elective
|
13 (40.6)
|
|
Emergency
|
4 (12.5)
|
|
Symptom control
|
2 ( 6.2)
|
|
NA
|
13 (40.6)
|
|
Response (%)
|
|
|
CR
|
1 ( 3.1)
|
|
PR
|
13 (40.6)
|
|
SD
|
7 (21.9)
|
|
PD
|
6 (18.8)
|
|
NA
|
5 (15.6)
|
|
x1L.Tox.G3.4 (%)
|
|
|
No
|
18 (56.2)
|
|
Si
|
11 (34.4)
|
|
NA
|
3 ( 9.4)
|
|
x1L.IO.Tox.PDN = Si (%)
|
4 (12.5)
|
Early-onset CRC
|
|
<51
|
>50
|
p
|
test
|
|
n
|
9
|
23
|
|
|
|
Gender = Male (%)
|
9 (100.0)
|
10 ( 43.5)
|
0.012
|
|
|
YearGroup = >50 (%)
|
0 ( 0.0)
|
23 (100.0)
|
<0.001
|
|
|
Ethnicity1 (%)
|
|
|
0.067
|
|
|
Asian
|
4 ( 44.4)
|
3 ( 13.0)
|
|
|
|
Black
|
0 ( 0.0)
|
1 ( 4.3)
|
|
|
|
Other
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
White
|
4 ( 44.4)
|
19 ( 82.6)
|
|
|
|
Site (%)
|
|
|
0.036
|
|
|
Right
|
3 ( 33.3)
|
18 ( 78.3)
|
|
|
|
Left
|
1 ( 11.1)
|
3 ( 13.0)
|
|
|
|
Rectum
|
3 ( 33.3)
|
1 ( 4.3)
|
|
|
|
Transverse
|
2 ( 22.2)
|
1 ( 4.3)
|
|
|
|
LynchSyndrome = Si (%)
|
0 ( 0.0)
|
2 ( 8.7)
|
0.919
|
|
|
Lymph.nodes = Si (%)
|
0 ( 0.0)
|
2 ( 8.7)
|
0.919
|
|
|
Lung.mets = Si (%)
|
1 ( 11.1)
|
3 ( 13.0)
|
1.000
|
|
|
Liver.mets = Si (%)
|
4 ( 44.4)
|
3 ( 13.0)
|
0.145
|
|
|
Bone.mets = Si (%)
|
0 ( 0.0)
|
0 ( 0.0)
|
NaN
|
|
|
Differentiation (%)
|
|
|
NaN
|
|
|
Mild
|
0 ( 0.0)
|
0 ( 0.0)
|
|
|
|
Moderate
|
8 ( 88.9)
|
13 ( 56.5)
|
|
|
|
Poor
|
1 ( 11.1)
|
10 ( 43.5)
|
|
|
|
Loss.MLH1 = Si (%)
|
6 ( 66.7)
|
17 ( 73.9)
|
1.000
|
|
|
Loss.MSH2 = Si (%)
|
2 ( 22.2)
|
5 ( 21.7)
|
1.000
|
|
|
Loss.MSH6 = Si (%)
|
3 ( 33.3)
|
4 ( 17.4)
|
0.613
|
|
|
Loss.PMS2 = Si (%)
|
7 ( 77.8)
|
18 ( 78.3)
|
1.000
|
|
|
BRAFmut (%)
|
|
|
0.255
|
|
|
No
|
4 ( 44.4)
|
13 ( 56.5)
|
|
|
|
Si
|
4 ( 44.4)
|
10 ( 43.5)
|
|
|
|
NA
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
BRAF.mut..specify. = NA (%)
|
5 ( 55.6)
|
13 ( 56.5)
|
1.000
|
|
|
KRASmut (%)
|
|
|
0.224
|
|
|
No
|
5 ( 55.6)
|
17 ( 73.9)
|
|
|
|
Si
|
3 ( 33.3)
|
6 ( 26.1)
|
|
|
|
NA
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
KRAS.mut..specify. (%)
|
|
|
0.529
|
|
|
A146W
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
G12D
|
1 ( 11.1)
|
1 ( 4.3)
|
|
|
|
G12D, A146W
|
0 ( 0.0)
|
1 ( 4.3)
|
|
|
|
G12D, G12R
|
1 ( 11.1)
|
1 ( 4.3)
|
|
|
|
G12W
|
0 ( 0.0)
|
1 ( 4.3)
|
|
|
|
G13D
|
0 ( 0.0)
|
2 ( 8.7)
|
|
|
|
NA
|
6 ( 66.7)
|
17 ( 73.9)
|
|
|
|
PIK3CAmut (%)
|
|
|
0.178
|
|
|
No
|
6 ( 66.7)
|
13 ( 56.5)
|
|
|
|
Si
|
2 ( 22.2)
|
10 ( 43.5)
|
|
|
|
NA
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
TP53mut (%)
|
|
|
0.263
|
|
|
No
|
6 ( 66.7)
|
18 ( 78.3)
|
|
|
|
Si
|
2 ( 22.2)
|
5 ( 21.7)
|
|
|
|
NA
|
1 ( 11.1)
|
0 ( 0.0)
|
|
|
|
CEA.dx.positive (%)
|
|
|
0.626
|
|
|
No
|
2 ( 22.2)
|
9 ( 39.1)
|
|
|
|
Si
|
5 ( 55.6)
|
9 ( 39.1)
|
|
|
|
NA
|
2 ( 22.2)
|
5 ( 21.7)
|
|
|
|
CA19.9.dx.positive (%)
|
|
|
0.989
|
|
|
No
|
2 ( 22.2)
|
5 ( 21.7)
|
|
|
|
Si
|
1 ( 11.1)
|
3 ( 13.0)
|
|
|
|
NA
|
6 ( 66.7)
|
15 ( 65.2)
|
|
|
|
Surgery = Si (%)
|
6 ( 66.7)
|
13 ( 56.5)
|
0.900
|
|
|
IO.Prior.Surgery (%)
|
|
|
0.362
|
|
|
No
|
6 ( 66.7)
|
10 ( 43.5)
|
|
|
|
Si
|
0 ( 0.0)
|
3 ( 13.0)
|
|
|
|
NA
|
3 ( 33.3)
|
10 ( 43.5)
|
|
|
|
Type.Surgery (%)
|
|
|
0.110
|
|
|
Elective
|
2 ( 22.2)
|
11 ( 47.8)
|
|
|
|
Emergency
|
3 ( 33.3)
|
1 ( 4.3)
|
|
|
|
Symptom control
|
1 ( 11.1)
|
1 ( 4.3)
|
|
|
|
NA
|
3 ( 33.3)
|
10 ( 43.5)
|
|
|
|
Response (%)
|
|
|
0.954
|
|
|
CR
|
0 ( 0.0)
|
1 ( 4.3)
|
|
|
|
PR
|
4 ( 44.4)
|
9 ( 39.1)
|
|
|
|
SD
|
2 ( 22.2)
|
5 ( 21.7)
|
|
|
|
PD
|
2 ( 22.2)
|
4 ( 17.4)
|
|
|
|
NA
|
1 ( 11.1)
|
4 ( 17.4)
|
|
|
|
x1L.Tox.G3.4 (%)
|
|
|
0.254
|
|
|
No
|
5 ( 55.6)
|
13 ( 56.5)
|
|
|
|
Si
|
2 ( 22.2)
|
9 ( 39.1)
|
|
|
|
NA
|
2 ( 22.2)
|
1 ( 4.3)
|
|
|
|
x1L.IO.Tox.PDN = Si (%)
|
1 ( 11.1)
|
3 ( 13.0)
|
1.000
|
|
Survival
## Call: survfit(formula = Surv(db$OSm, db$Death..Y.1.N.0.) ~ X1L.Drug..name.,
## data = db, type = "kaplan-meier")
##
## n events median 0.95LCL 0.95UCL
## X1L.Drug..name.=Nivolumab + Ipilimumab 11 0 NA NA NA
## X1L.Drug..name.=Pembrolizumab 21 5 NA 15.3 NA
## Call: survfit(formula = Surv(db$OSm, db$Death..Y.1.N.0.) ~ BRAFmut,
## data = db, type = "kaplan-meier")
##
## 1 observation deleted due to missingness
## n events median 0.95LCL 0.95UCL
## BRAFmut=No 17 0 NA NA NA
## BRAFmut=Si 14 5 15.3 11.9 NA
