Determine Heart Feailure Medications
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Review heart failure drug guielines. References include:
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Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline
for the Management of Heart Failure: A report of the American College of
Cardiology/American Heart Association joint committee on clinical
practice guidelines. Circulation. 2022;145(18):e895-e1032.
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Hood SR, Giazzon AJ, Seamon G, et al. Association between medication
adherence and the outcomes of heart failure. Pharmacotherapy.
2018;38(5):539-545.
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Hamo CE, Mukhopadhyay A, Li X, et al. Association between visit
frequency, continuity of care, and pharmacy fill adherence in heart
failure patients. Am Heart J. 2024;273:53-60.
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Mukhopadhyay A, Blecker S, Li X, et al. Neighborhood-level socioeconomic
status and prescription fill patterns among patients with heart failure.
JAMA Netw Open. 2023;6(12):e2347519.
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Yancy CW, Jessup M, Bozkurt B, et al. 2017 ACC/AHA/HFSA focused update
of the 2013 ACCF/AHA guideline for the management of heart failure: A
report of the American college of cardiology/American heart association
task force on clinical practice guidelines and the heart failure society
of America. J Card Fail. 2017;23(8):628-651.
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Heart Failure Society of America. Executive summary: HFSA 2010
comprehensive heart failure practice guideline. J Card Fail.
2010;16(6):475-539.
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Garred CH, Zahir D, Butt JH, et al. Adherence and discontinuation of
optimal heart failure therapies according to age: A danish nationwide
study. J Am Heart Assoc. 2022;11(19):e026187.
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The medications included as Guideline-Directed Medical Therapy (GDMT)
included the following classes, grouped into four categories:
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Beta Blockers (BB)
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Angiotensin-Converting Enzyme I nhibitor (ACEI), Angiotensin Receptor
Blocker (ARB), or Angiotensin Receptor-Neprilysin Inhibitor (ARNI)
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Mineralocorticoid Receptor Antagonist (MRA)
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Sodium-Glucose Cotransporter 2 Inhibitor (SGLT2i)
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Other drug classes used in heart failure but NOT included in this
study due to lack of use in the literature: Diuretics, Hydral Nitrates,
I Channel Inhibitors, Soluble Guanylate Cyclase Simulator, and Cardiac
Glycoside
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The full list of medications included as GDMT, broken down by medication
class. For each medication, long-acting, short-acting, brand-name, and
combination drug formulations were all included.
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BB: Bisoprolol, Carvedilol, Metoprolol (Succinate or Tartrate)
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ACEI: Benazepril, Captopril, Enalapril, Fosinopril, Lisinopril,
Moexipril, Perindopril, Quinapril, Ramipril, Trandolapril
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ARB: Azilsartan, Candesartan, Eprosartan, Irbesartan, Losartan,
Olmesartan, Telmisartan, Valsartan
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ARNI: Sacubritil/Valsartan
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MRA: Epleronone, Spironolactone
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SGLT2i:Dapagliflozin, Empagliflozin
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Medications for each class were taken from 2022 AHA/ACC/HFSA Heart
Failure Guidelines as well as 2023 paper by Mukhopadhyay et. al.
Pulling the NDC Dataset
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Download FDA National Drug Code Directory as .txt file
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Link
to FDA National Drug Code Directory
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Import “Product.txt” file into R
All_NDC <- read.delim("~/Downloads/ndctext/product.txt")
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Filter datasset by requested NDCs; Search the All_NDC dataset
“NonProprietaryName” column to ensure capturing all spelling and
capitalization for each drug product (may not be necessary if adjust
Case Sensititivy)
library(dplyr)
##
## Attaching package: 'dplyr'
## The following objects are masked from 'package:stats':
##
## filter, lag
## The following objects are masked from 'package:base':
##
## intersect, setdiff, setequal, union
HF_NDC <- filter(All_NDC,
NONPROPRIETARYNAME == "bisoprolol fumarate" |
NONPROPRIETARYNAME == "Bisoprolol fumarate" |
NONPROPRIETARYNAME == "Bisoprolol Fumarate" |
NONPROPRIETARYNAME == "BISOPROLOL FUMARATE" |
NONPROPRIETARYNAME == "bisoprolol fumarate and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Bisoprolol Fumarate and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Carvedilol" |
NONPROPRIETARYNAME == "CARVEDILOL" |
NONPROPRIETARYNAME == "carvedilol phosphate" |
NONPROPRIETARYNAME == "Carvedilol Phosphate" |
NONPROPRIETARYNAME == "CARVEDILOL PHOSPHATE" |
NONPROPRIETARYNAME == "METOPROLOL" |
NONPROPRIETARYNAME == "Metoprolol Succinate" |
NONPROPRIETARYNAME == "Metoprolol succinate" |
NONPROPRIETARYNAME == "metoprolol succinate" |
NONPROPRIETARYNAME == "METOPROLOL SUCCINATE" |
NONPROPRIETARYNAME == "Metoprolol Succinate ER Tablets" |
NONPROPRIETARYNAME == "Metoprolol Tartrate" |
NONPROPRIETARYNAME == "Metoprolol tartrate" |
NONPROPRIETARYNAME == "metoprolol tartrate" |
NONPROPRIETARYNAME == "METOPROLOL TARTRATE" |
NONPROPRIETARYNAME == "metoprolol tartrate and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Metoprolol Tartrate and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Benazepril" |
NONPROPRIETARYNAME == "Amlodipine and Benazepril Hydrochloride" |
NONPROPRIETARYNAME == "AMLODIPINE AND BENAZEPRIL HYDROCHLORIDE" |
NONPROPRIETARYNAME == "amlodipine besylate and benazepril hydrochloride" |
NONPROPRIETARYNAME == "Amlodipine Besylate and Benazepril Hydrochloride" |
NONPROPRIETARYNAME == "benazepril hydrochloride" |
NONPROPRIETARYNAME == "Benazepril Hydrochloride" |
NONPROPRIETARYNAME == "Benazepril hydrochloride" |
NONPROPRIETARYNAME == "benazepril hydrochloride and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Benazepril Hydrochloride and HydrochlorothiazideE" |
NONPROPRIETARYNAME == "BENAZEPRIL HYDROCHLORIDE" |
NONPROPRIETARYNAME == "Captopril" |
NONPROPRIETARYNAME == "captopril" |
NONPROPRIETARYNAME == "CAPTOPRIL AND HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "enalapril maleate" |
NONPROPRIETARYNAME == "Enalapril" |
NONPROPRIETARYNAME == "Enalapril maleate" |
NONPROPRIETARYNAME == "Enalapril Maleate" |
NONPROPRIETARYNAME == "ENALAPRIL MALEATE" |
NONPROPRIETARYNAME == "enalapril maleate and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Enalapril maleate and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Enalapril Maleate and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Enalapril Maleate Oral Solution" |
NONPROPRIETARYNAME == "Fosinopril" |
NONPROPRIETARYNAME == "fosinopirl sodium" |
NONPROPRIETARYNAME == "Fosinopril sodium" |
NONPROPRIETARYNAME == "Fosinopril Sodium" |
NONPROPRIETARYNAME == "Fosinopril Sodium and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Lisinopril" |
NONPROPRIETARYNAME == "lisinopril" |
NONPROPRIETARYNAME == "LISINOPRIL" |
NONPROPRIETARYNAME == "lisinopril and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Lisinopril and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Lisinopril and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "LISINOPRIL and HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "LISINOPRIL AND HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "Lisinopril and Hydrochlorothiazide Tablets" |
NONPROPRIETARYNAME == "Lisinopril/HCTZ" |
NONPROPRIETARYNAME == "Moexipril Hydrochloride" |
NONPROPRIETARYNAME == "Perindopril Erbumine" |
NONPROPRIETARYNAME == "Quinapril" |
NONPROPRIETARYNAME == "quinapril" |
NONPROPRIETARYNAME == "Quinapril and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "quinapril and Hydrochlorothiazide 10/12.5" |
NONPROPRIETARYNAME == "Quinapril and Hydrochlorothiazide 20/12.5" |
NONPROPRIETARYNAME == "Quinapril and Hydrochlorothiazide 20/25" |
NONPROPRIETARYNAME == "Quinapril HCl and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Quinapril HCL and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Quinapril Hydrochloride" |
NONPROPRIETARYNAME == "QUINAPRIL HYDROCHLORIDE/HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "Ramipril" |
NONPROPRIETARYNAME == "ramipril" |
NONPROPRIETARYNAME == "Trandolapril" |
NONPROPRIETARYNAME == "Trandolapril and Verapamil Hydrochloride" |
NONPROPRIETARYNAME == "Trandolapril Tablets" |
NONPROPRIETARYNAME == "Azilsartan kamedoxomil and chlorthalidone" |
NONPROPRIETARYNAME == "Azilsartan kamedoxomil" |
NONPROPRIETARYNAME == "Candesartan" |
NONPROPRIETARYNAME == "candesartan cilexetil" |
NONPROPRIETARYNAME == "Candesartan cilexetil" |
NONPROPRIETARYNAME == "Candesartan Cilexetil" |
NONPROPRIETARYNAME == "CANDESARTAN CILEXETIL" |
NONPROPRIETARYNAME == "candesartan cilexetil and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Candesartan Cilexetil and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Eprosartan" |
NONPROPRIETARYNAME == "Irbesartan" |
NONPROPRIETARYNAME == "irbesartan" |
NONPROPRIETARYNAME == "IRBESARTAN" |
NONPROPRIETARYNAME == "irbesartan and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Irbesartan and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Losartan" |
NONPROPRIETARYNAME == "losartan potassium" |
NONPROPRIETARYNAME == "Losartan potassium" |
NONPROPRIETARYNAME == "Losartan Potassium" |
NONPROPRIETARYNAME == "LOSARTAN POTASSIUM" |
NONPROPRIETARYNAME == "losartan potassium and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Losartan potassium and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Losartan Potassium and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "Olmesartan" |
NONPROPRIETARYNAME == "Aamlodipine and Olmesartan Medoxomil" |
NONPROPRIETARYNAME == "Amlodipine and olmesartan Medoxomil" |
NONPROPRIETARYNAME == "Amlodipine and Olmesartan Medoxomil" |
NONPROPRIETARYNAME == "AMLODIPINE and OLMESARTAN medoxomil" |
NONPROPRIETARYNAME == "amlodipine besylate and olmesartan medoxomil" |
NONPROPRIETARYNAME == "Amlodipine besylate and Olmesartan medoxomil" |
NONPROPRIETARYNAME == "olmesartan medoxomil" |
NONPROPRIETARYNAME == "Olmesartan medoxomil" |
NONPROPRIETARYNAME == "Olmesartan Medoxomil" |
NONPROPRIETARYNAME == "OLMESARTAN MEDOXOMIL" |
NONPROPRIETARYNAME == "olmesartan medoxomil / amlodipine besylate / hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan medoxomil Amlodipine and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "olmesartan medoxomil and amlodipine besylate and hydrochlorothiazide" |
NONPROPRIETARYNAME == "olmesartan medoxomil and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan medoxomil and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan Medoxomil and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "OLMESARTAN MEDOXOMIL and HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE" |
NONPROPRIETARYNAME == "olmesartan medoxomil-hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan medoxomil, amlodipine and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide Tablet 20/5/12.5 mg" |
NONPROPRIETARYNAME == "Telmisartan" |
NONPROPRIETARYNAME == "telmisartan" |
NONPROPRIETARYNAME == "TELMISARTAN" |
NONPROPRIETARYNAME == "telmisartan and amlodipine" |
NONPROPRIETARYNAME == "Telmisartan and Amlodipine" |
NONPROPRIETARYNAME == "telmisartan and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Telmisartan and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "telmisartan, amlodipine and indapamide" |
NONPROPRIETARYNAME == "amlodipine and valsartan" |
NONPROPRIETARYNAME == "Amlodipine and valsartan" |
NONPROPRIETARYNAME == "Amlodipine and Valsartan" |
NONPROPRIETARYNAME == "AMLODIPINE AND VALSARTAN" |
NONPROPRIETARYNAME == "amlodipine besylate valsartan hydrochlorothiazide" |
NONPROPRIETARYNAME == "amlodipine besylate and valsartan" |
NONPROPRIETARYNAME == "amlodipine valsartan and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Amlodipine, Valsartan and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "amlodipine,valsartan and hydrochlorothiazide" |
NONPROPRIETARYNAME == "valsartan" |
NONPROPRIETARYNAME == "Valsartan" |
NONPROPRIETARYNAME == "VALSARTAN" |
NONPROPRIETARYNAME == "valsartan and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Valsartan and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "Valsartan oral" |
NONPROPRIETARYNAME == "sacubitril and valsartan" |
NONPROPRIETARYNAME == "Sacubitril and valsartan" |
NONPROPRIETARYNAME == "Sacubitril and Valsartan" |
NONPROPRIETARYNAME == "eplerenone" |
NONPROPRIETARYNAME == "Eplerenone" |
NONPROPRIETARYNAME == "EPLERENONE" |
NONPROPRIETARYNAME == "spironolactone" |
NONPROPRIETARYNAME == "Spironolactone" |
NONPROPRIETARYNAME == "SPIRONOLACTONE" |
NONPROPRIETARYNAME == "spironolactone and hydrochlorothiazide" |
NONPROPRIETARYNAME == "Spironolactone and Hydrochlorothiazide" |
NONPROPRIETARYNAME == "DAPAGLIFLOZIN" |
NONPROPRIETARYNAME == "dapagliflozin and metformin hydrochloride" |
NONPROPRIETARYNAME == "dapagliflozin and saxagliptin" |
NONPROPRIETARYNAME == "Empagliflozin" |
NONPROPRIETARYNAME == "empagliflozin and linagliptin" |
NONPROPRIETARYNAME == "empagliflozin and metformin hydrochloride" |
NONPROPRIETARYNAME == "empagliflozin, linagliptin, metformin hydrochloride" |
NONPROPRIETARYNAME == "empagliflozin, metformin hydrochloride")
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Save list as CSV File
write.csv(HF_NDC, "HeartFailure_NDC.csv")