Marijuana and Blood Pressure Analyses 12 - 17 - 2015

save(exdata,file ="/Users/meganwilliams/Desktop/Research/Cannabis and Cardiovascular Disease/exdata.rdata")

Systolic Blood Pressure

model1 = lm(PhysMeanSBPsitimp~MedHxMarijStatusCurrent + Sex + Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + PhysBMI, data = exdata)

summary(model1)
## 
## Call:
## lm(formula = PhysMeanSBPsitimp ~ MedHxMarijStatusCurrent + Sex + 
##     Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + 
##     MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + 
##     CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + 
##     PhysBMI, data = exdata)
## 
## Residuals:
##    Min     1Q Median     3Q    Max 
## -43.39 -10.67  -1.62   9.53  78.66 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)
## (Intercept)               80.6164     3.3598   23.99  < 2e-16
## MedHxMarijStatusCurrent1   3.7480     1.0026    3.74  0.00019
## SexMen                     3.2578     0.6542    4.98  6.8e-07
## RaceAfrAm                  2.9667     0.6464    4.59  4.6e-06
## Age0                       0.5060     0.0365   13.88  < 2e-16
## HseHldEducation           -0.2025     0.1095   -1.85  0.06449
## PovStatBelow               1.7689     0.6657    2.66  0.00792
## MedHxCigaretteStatusNFC   -0.7511     0.4229   -1.78  0.07579
## MedHxAlcStatusNFC          0.7366     0.4048    1.82  0.06889
## MedHxCokeStatusNFC         0.6370     0.6675    0.95  0.34000
## MedHxOpiateStatusNFC      -2.7310     0.8014   -3.41  0.00066
## CESimp                     0.0253     0.0288    0.88  0.37999
## DMMclusterdich1           -0.5289     0.7413   -0.71  0.47556
## CVDclusterdich1           -2.4808     1.4135   -1.76  0.07935
## MedHxMedsBP                5.0348     0.7537    6.68  2.9e-11
## PhysBMI                    0.4835     0.0430   11.24  < 2e-16
## 
## Residual standard error: 16.1 on 2712 degrees of freedom
##   (74 observations deleted due to missingness)
## Multiple R-squared:  0.183,  Adjusted R-squared:  0.179 
## F-statistic: 40.6 on 15 and 2712 DF,  p-value: <2e-16

Pulse Pressure

model2 = lm(PhysMeanPPsitimp~MedHxMarijStatusCurrent + Sex + Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + PhysBMI, data = exdata)

summary(model2)
## 
## Call:
## lm(formula = PhysMeanPPsitimp ~ MedHxMarijStatusCurrent + Sex + 
##     Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + 
##     MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + 
##     CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + 
##     PhysBMI, data = exdata)
## 
## Residuals:
##    Min     1Q Median     3Q    Max 
## -41.55  -7.58  -1.42   6.11  53.64 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)
## (Intercept)               15.8634     2.4141    6.57  6.0e-11
## MedHxMarijStatusCurrent1   2.8602     0.7204    3.97  7.4e-05
## SexMen                    -0.2257     0.4701   -0.48   0.6311
## RaceAfrAm                  2.1462     0.4644    4.62  4.0e-06
## Age0                       0.4679     0.0262   17.86  < 2e-16
## HseHldEducation           -0.0819     0.0787   -1.04   0.2981
## PovStatBelow               0.4041     0.4783    0.84   0.3982
## MedHxCigaretteStatusNFC    0.1664     0.3038    0.55   0.5839
## MedHxAlcStatusNFC          0.3710     0.2909    1.28   0.2022
## MedHxCokeStatusNFC        -0.5471     0.4796   -1.14   0.2541
## MedHxOpiateStatusNFC      -1.3908     0.5758   -2.42   0.0158
## CESimp                     0.0132     0.0207    0.64   0.5234
## DMMclusterdich1            1.2212     0.5326    2.29   0.0219
## CVDclusterdich1            0.3305     1.0156    0.33   0.7449
## MedHxMedsBP                1.5706     0.5416    2.90   0.0038
## PhysBMI                    0.2916     0.0309    9.43  < 2e-16
## 
## Residual standard error: 11.6 on 2712 degrees of freedom
##   (74 observations deleted due to missingness)
## Multiple R-squared:  0.193,  Adjusted R-squared:  0.189 
## F-statistic: 43.3 on 15 and 2712 DF,  p-value: <2e-16

Diastolic Blood Pressure

model3 = lm(PhysMeanDBPsitimp~MedHxMarijStatusCurrent + Sex + Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + PhysBMI, data = exdata)

summary(model3)
## 
## Call:
## lm(formula = PhysMeanDBPsitimp ~ MedHxMarijStatusCurrent + Sex + 
##     Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + 
##     MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + 
##     CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + 
##     PhysBMI, data = exdata)
## 
## Residuals:
##    Min     1Q Median     3Q    Max 
## -32.76  -7.64  -0.14   6.99  40.08 
## 
## Coefficients:
##                          Estimate Std. Error t value Pr(>|t|)
## (Intercept)               64.7530     2.1795   29.71  < 2e-16
## MedHxMarijStatusCurrent1   0.8878     0.6504    1.37  0.17232
## SexMen                     3.4835     0.4244    8.21  3.4e-16
## RaceAfrAm                  0.8205     0.4193    1.96  0.05047
## Age0                       0.0381     0.0236    1.61  0.10758
## HseHldEducation           -0.1207     0.0710   -1.70  0.08953
## PovStatBelow               1.3647     0.4318    3.16  0.00159
## MedHxCigaretteStatusNFC   -0.9176     0.2743   -3.35  0.00083
## MedHxAlcStatusNFC          0.3656     0.2626    1.39  0.16392
## MedHxCokeStatusNFC         1.1841     0.4330    2.73  0.00629
## MedHxOpiateStatusNFC      -1.3402     0.5198   -2.58  0.00999
## CESimp                     0.0121     0.0187    0.65  0.51788
## DMMclusterdich1           -1.7502     0.4809   -3.64  0.00028
## CVDclusterdich1           -2.8113     0.9169   -3.07  0.00219
## MedHxMedsBP                3.4642     0.4889    7.09  1.8e-12
## PhysBMI                    0.1918     0.0279    6.87  7.7e-12
## 
## Residual standard error: 10.4 on 2712 degrees of freedom
##   (74 observations deleted due to missingness)
## Multiple R-squared:  0.0794, Adjusted R-squared:  0.0743 
## F-statistic: 15.6 on 15 and 2712 DF,  p-value: <2e-16

Effect Plots for Systolic Blood Pressure as a Function of Marijuana Status and other covariates

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Effect Plots for Pulse Pressure as a Function of Marijuana Status and other covariates

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Effect Plots for Diastolic Blood Pressure as a Function of Marijuana Status and other covariates

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Most Important Finding from Our Analyses:

# Results from a linear multiple regression analysis revealed significant main effects for systolic blood pressure (b = 3.75, SE = 1.00, p < .001) and pulse pressure  (b = - 2.86,SE = 2.25, p < .001). These results suggest that current marijuana use may be associated with an increase in systolic blood pressure and pulse pressure in adults.

library(effects) mod <- lm(PhysMeanPPsitimp~MedHxMarijStatusCurrent + Sex + Race + Age0 + HseHldEducation + PovStat + MedHxCigaretteStatusNFC + MedHxAlcStatusNFC + MedHxCokeStatusNFC + MedHxOpiateStatusNFC + CESimp + DMMclusterdich + CVDclusterdich + MedHxMedsBP + PhysBMI, data = exdata)

eff.mod <- allEffects(mod, xlevels=list(MedHxMarijStatusCurrent=0:1)) plot(eff.mod,'MedHxMarijStatusCurrent', ylab="Systolic Blood Pressure", type="h",grid=TRUE, rotx=90, lty=0)