Table 2. Clinical, laboratory and echo parameters at baseline, 1 month and 12 months
Continuous: Paired t-test if Shapiro(diff) OK, else Wilcoxon; Global: RM-ANOVA (GG) if normal diffs, else Friedman. Binary: McNemar pairwise; Global: Cochran’s Q.
Variable	n (B/1m/12m)	Baseline	1 month	p (B–1m)	12 months	p (B–12m)	Pairwise test (B–1m)	Pairwise test (B–12m)	Global test	Global p	Assumptions/notes
NYHA≥3 (nº, %)	34/32/22	22 (65%)	1 (3%)	<0.001	3 (14%)	0.008	McNemar (cc)	McNemar (cc)	Cochran's Q	<0.001	Discordant=19 | Discordant=9 | n=22
Edema (nº, %)	34/32/22	18 (53%)	4 (12%)	0.002	2 (9%)	0.008	McNemar (cc)	McNemar (cc)	Cochran's Q	<0.001	Discordant=15 | Discordant=9 | n=22
Ascitis (nº, %)	34/32/22	9 (26%)	0 (0%)	0.023	1 (5%)	0.221	McNemar (cc)	McNemar (cc)	Cochran's Q	0.030	Discordant=7 | Discordant=6 | n=22
Elastography (kPa)	34/28/17	7.0 (6.0-10.0)	6.1 (4.8-7.5)	0.003	6.0 (5.0-7.5)	0.013	Paired t-test	Paired t-test	RM-ANOVA (GG)	0.040	Shapiro(diff) p=0.442 | Shapiro(diff) p=0.158 | Shapiro diffs p=0.862, 0.517, 0.937; Mauchly W=0.997 p=0.980
VEXUS (%)	34/28/18	2 (0-2)	1 (0-2)	0.058	1 (0-2)	0.166	Wilcoxon signed-rank	Paired t-test	Friedman	0.283	Shapiro(diff) p=0.041 | Shapiro(diff) p=0.328 | Friedman (non-normal); Shapiro diffs p=0.034, 0.492, 0.042
Basal RV diameter (mm)	34/32/21	47.2 (± 5.8)	45.7 (± 5.9)	0.010	43.6 (± 6.6)	0.003	Wilcoxon signed-rank	Paired t-test	Friedman	0.008	Shapiro(diff) p=0.003 | Shapiro(diff) p=0.928 | Friedman (non-normal); Shapiro diffs p=0.001, 0.928, 0.387
Right atrium area (cm2)	34/31/21	28.6 (± 7.6)	28.0 (± 6.1)	0.420	28.1 (± 8.9)	0.267	Paired t-test	Paired t-test	RM-ANOVA (GG)	0.340	Shapiro(diff) p=0.706 | Shapiro(diff) p=0.156 | Shapiro diffs p=0.643, 0.194, 0.113; Mauchly W=0.857 p=0.250
TAPSE (mm)	33/31/21	18.0 (15.0-21.0)	18.0 (16.5-22.0)	0.789	18.0 (16.0-20.0)	0.752	Paired t-test	Paired t-test	Friedman	0.446	Shapiro(diff) p=0.675 | Shapiro(diff) p=0.276 | Friedman (non-normal); Shapiro diffs p=0.691, 0.276, 0.002
S' Wave (cm/s)	34/32/21	11.0 (9.0-12.8)	9.2 (8.5-11.2)	0.008	8.7 (8.3-11.1)	0.058	Paired t-test	Wilcoxon signed-rank	Friedman	0.139	Shapiro(diff) p=0.740 | Shapiro(diff) p=0.010 | Friedman (non-normal); Shapiro diffs p=0.101, 0.010, 0.634
FAC (%)	34/32/21	38.3 (± 8.4)	40.0 (± 9.4)	0.440	39.4 (± 10.4)	0.286	Paired t-test	Wilcoxon signed-rank	Friedman	0.611	Shapiro(diff) p=0.137 | Shapiro(diff) p=0.011 | Friedman (non-normal); Shapiro diffs p=0.056, 0.011, 0.009
RV-FWLS (%)	4/3/1	0.4 (0.4-0.5)	0.9 (0.7-1.0)	NA	1.0 (1.0-1.0)	NA	NA	NA	NA	NA	Insufficient pairs | Insufficient pairs | Insufficient complete cases
PASP (mmHg)	34/32/21	45.6 (± 11.6)	32.7 (± 11.1)	<0.001	34.8 (± 12.8)	0.007	Paired t-test	Paired t-test	RM-ANOVA (GG)	0.002	Shapiro(diff) p=0.117 | Shapiro(diff) p=0.687 | Shapiro diffs p=0.100, 0.687, 0.068; Mauchly W=0.989 p=0.897
TR vena contracta (mm)	34/32/21	9.8 (8.2-12.4)	3.0 (2.0-4.0)	<0.001	4.0 (2.0-5.0)	<0.001	Wilcoxon signed-rank	Wilcoxon signed-rank	Friedman	<0.001	Shapiro(diff) p=0.045 | Shapiro(diff) p=0.048 | Friedman (non-normal); Shapiro diffs p=0.577, 0.048, 0.018
IVC diameter (mm)	33/32/21	22.8 (± 3.8)	17.9 (± 5.3)	<0.001	17.8 (± 6.1)	<0.001	Paired t-test	Paired t-test	RM-ANOVA (GG)	<0.001	Shapiro(diff) p=0.159 | Shapiro(diff) p=0.908 | Shapiro diffs p=0.166, 0.908, 0.211; Mauchly W=0.982 p=0.840
Hemoglobine (g/dL)	34/28/22	13.6 (± 1.7)	13.6 (± 1.7)	0.520	14.0 (± 1.0)	0.019	Paired t-test	Paired t-test	RM-ANOVA (GG)	0.034	Shapiro(diff) p=0.212 | Shapiro(diff) p=0.312 | Shapiro diffs p=0.554, 0.469, 0.268; Mauchly W=0.794 p=0.126
Platelets (x 103/mm3)	34/28/22	175 (± 55)	181 (± 56)	0.150	178 (± 50)	0.355	Paired t-test	Paired t-test	RM-ANOVA (GG)	0.284	Shapiro(diff) p=0.445 | Shapiro(diff) p=0.686 | Shapiro diffs p=0.527, 0.506, 0.351; Mauchly W=0.994 p=0.950
Creatinine (mg/dL)	34/29/22	1.1 (0.9-1.4)	1.1 (0.9-1.4)	0.525	1.1 (0.9-1.5)	0.037	Wilcoxon signed-rank	Wilcoxon signed-rank	Friedman	0.046	Shapiro(diff) p=<0.001 | Shapiro(diff) p=0.005 | Friedman (non-normal); Shapiro diffs p=0.366, 0.007, 0.051
NT-proBNP (pg/ml)	34/29/22	1902 (1019-3358)	1494 (980-3628)	0.449	1310 (807-2470)	0.603	Wilcoxon signed-rank	Wilcoxon signed-rank	Friedman	0.795	Shapiro(diff) p=<0.001 | Shapiro(diff) p=<0.001 | Friedman (non-normal); Shapiro diffs p=0.090, <0.001, <0.001
Alkaline Phosphatase (IU/L)	32/27/22	94 (± 39)	88 (± 38)	0.435	99 (± 35)	0.586	Wilcoxon signed-rank	Paired t-test	Friedman	0.196	Shapiro(diff) p=<0.001 | Shapiro(diff) p=0.182 | Friedman (non-normal); Shapiro diffs p=<0.001, 0.138, <0.001
ALT (IU/L)	34/29/22	20 (18-30)	18 (16-25)	0.353	17 (15-23)	0.091	Wilcoxon signed-rank	Paired t-test	Friedman	0.363	Shapiro(diff) p=0.005 | Shapiro(diff) p=0.166 | Friedman (non-normal); Shapiro diffs p=0.003, 0.196, 0.012
AST (IU/L)	34/29/22	26 (22-34)	27 (23-32)	0.460	23 (18-25)	0.071	Wilcoxon signed-rank	Paired t-test	Friedman	0.036	Shapiro(diff) p=0.037 | Shapiro(diff) p=0.081 | Friedman (non-normal); Shapiro diffs p=0.097, 0.063, <0.001
GGT (IU/L)	33/29/22	42 (27-140)	51 (24-105)	0.218	64 (27-144)	0.543	Wilcoxon signed-rank	Wilcoxon signed-rank	Friedman	0.529	Shapiro(diff) p=0.010 | Shapiro(diff) p=0.001 | Friedman (non-normal); Shapiro diffs p=0.321, <0.001, <0.001
Bilirrubine (mg/dL)	34/29/22	0.8 (0.7-1.2)	0.9 (0.6-1.1)	0.316	0.9 (0.8-1.0)	0.626	Paired t-test	Wilcoxon signed-rank	Friedman	0.414	Shapiro(diff) p=0.244 | Shapiro(diff) p=0.022 | Friedman (non-normal); Shapiro diffs p=0.249, 0.022, 0.004