Table 1

Univeriate linear regression los

outcome los
Characteristic N Beta 95% CI1 p-value
time 621


    1
— —
    2
-0.60 -2.1, 0.91 0.438
group 621


    BWH
— —
    MGH
-0.49 -2.0, 1.0 0.521
Age 621 -0.01 -0.07, 0.05 0.651
Gender 621


    Female
— —
    Male
0.62 -0.88, 2.1 0.419
Race_Group 621


    Black
— —
    Others
-0.01 -2.3, 2.3 0.995
    White
2.8 0.98, 4.7 0.003
UF_rate 621 -0.40 -0.57, -0.23 <0.001
Access_type 621


    AVF
— —
    AVG
-0.42 -3.6, 2.8 0.794
    TDC
5.0 3.5, 6.5 <0.001
Dialysis_Vintage 621 -0.06 -0.33, 0.21 0.668
HF_score_Total 621 0.17 0.08, 0.26 <0.001
1 CI = Confidence Interval

Multivariatelinear regression los: time*group

outcome los
Characteristic N Beta 95% CI1 p-value
time



    1 243 — —
    2 378 1.2 -1.2, 3.5 0.333
group



    BWH 253 — —
    MGH 368 1.3 -1.0, 3.7 0.274
time * group 621


    2 * MGH 234 -3.0 -6.0, 0.09 0.058
1 CI = Confidence Interval

Multivariatelinear regression los: time*group +Age+ Race_Group + Gender

outcome los
Characteristic N Beta 95% CI1 p-value
time



    1 243 — —
    2 378 1.3 -1.0, 3.6 0.267
group



    BWH 253 — —
    MGH 368 1.1 -1.3, 3.4 0.369
Age 621 -0.03 -0.09, 0.03 0.261
Race_Group



    Black 133 — —
    Others 116 0.17 -2.2, 2.5 0.884
    White 372 3.2 1.2, 5.1 0.001
Gender



    Female 260 — —
    Male 361 0.28 -1.2, 1.8 0.709
time * group 621


    2 * MGH 234 -3.1 -6.2, -0.07 0.045
1 CI = Confidence Interval

Multivariate linear regression los ： time*group+ Race_Group + Gender+ UF_rate+Access_type+Dialysis_Vintage+HF_score_Total

outcome los
Characteristic N Beta 95% CI1 p-value
time



    1 243 — —
    2 378 0.51 -1.7, 2.7 0.655
group



    BWH 253 — —
    MGH 368 1.0 -1.3, 3.4 0.373
Race_Group



    Black 133 — —
    Others 116 -0.15 -2.4, 2.1 0.898
    White 372 2.1 0.26, 3.9 0.026
Gender



    Female 260 — —
    Male 361 -0.04 -1.5, 1.4 0.954
UF_rate 621 -0.27 -0.44, -0.09 0.003
Access_type



    AVF 365 — —
    AVG 34 -0.72 -3.9, 2.4 0.656
    TDC 222 4.7 3.1, 6.2 <0.001
Dialysis_Vintage 621 0.23 -0.04, 0.49 0.102
HF_score_Total 621 0.09 0.00, 0.18 0.052
time * group 621


    2 * MGH 234 -2.7 -5.7, 0.23 0.071
1 CI = Confidence Interval

test posissin assumption

## 
##  Overdispersion test
## 
## data:  model
## z = 1.8237, p-value = 0.0341
## alternative hypothesis: true dispersion is greater than 1
## sample estimates:
## dispersion 
##   1.215065

## 
##  DHARMa zero-inflation test via comparison to expected zeros with
##  simulation under H0 = fitted model
## 
## data:  simulationOutput
## ratioObsSim = 1.0212, p-value = 0.586
## alternative hypothesis: two.sided

Univariate 90 days Negative Binomial

Outcome: n_90 (Negative Binomial )
Characteristic N IRR1 95% CI1 p-value
time 621


    1
— —
    2
0.87 0.70, 1.09 0.237
group 621


    BWH
— —
    MGH
0.61 0.49, 0.77 <0.001
Age 621 1.00 0.99, 1.01 0.730
Gender 621


    Female
— —
    Male
1.00 0.80, 1.25 >0.999
Race_Group 621


    Black
— —
    Others
0.73 0.51, 1.04 0.079
    White
0.86 0.66, 1.12 0.258
UF_rate 621 1.00 0.98, 1.03 0.862
Access_type 621


    AVF
— —
    AVG
0.93 0.55, 1.51 0.787
    TDC
0.89 0.70, 1.13 0.354
Dialysis_Vintage 621 0.99 0.94, 1.03 0.673
HF_score_Total 621 1.00 0.98, 1.01 0.819
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days Negative Binomial : time*group

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.95 0.72, 1.25 0.699
group



    BWH 253 — —
    MGH 368 0.66 0.48, 0.90 0.008
time * group 621


    2 * MGH 234 0.90 0.60, 1.36 0.629
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days Negative Binomial : time*group+Age+Gender+Race_Group

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.96 0.70, 1.30 0.775
group



    BWH 253 — —
    MGH 368 0.67 0.48, 0.94 0.022
Age 621 1.00 0.99, 1.01 0.948
Gender



    Female 260 — —
    Male 361 1.01 0.81, 1.27 0.904
Race_Group



    Black 133 — —
    Others 116 0.78 0.54, 1.11 0.163
    White 372 0.93 0.71, 1.23 0.613
time * group 621


    2 * MGH 234 0.89 0.57, 1.38 0.591
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

90 days Negative Binomial ： time*group+ Race_Group + Gender+ UF_rate+Access_type+Dialysis_Vintage+HF_score_Total

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.97 0.71, 1.32 0.828
group



    BWH 253 — —
    MGH 368 0.66 0.47, 0.94 0.021
Race_Group



    Black 133 — —
    Others 116 0.78 0.55, 1.12 0.184
    White 372 0.96 0.73, 1.27 0.759
Gender



    Female 260 — —
    Male 361 1.03 0.82, 1.30 0.802
UF_rate 621 1.01 0.98, 1.03 0.712
Access_type



    AVF 365 — —
    AVG 34 1.01 0.60, 1.63 0.975
    TDC 222 0.92 0.72, 1.18 0.521
Dialysis_Vintage 621 0.98 0.93, 1.02 0.359
HF_score_Total 621 1.00 0.98, 1.01 0.502
time * group 621


    2 * MGH 234 0.88 0.56, 1.38 0.570
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

Univariate 180 days Negative Binomial

Outcome: n_180 (Negative Binomial )
Characteristic N IRR1 95% CI1 p-value
time 621


    1
— —
    2
0.76 0.62, 0.93 0.007
group 621


    BWH
— —
    MGH
0.61 0.50, 0.74 <0.001
Age 621 0.99 0.99, 1.00 0.092
Gender 621


    Female
— —
    Male
0.95 0.78, 1.17 0.647
Race_Group 621


    Black
— —
    Others
0.88 0.65, 1.20 0.419
    White
0.81 0.63, 1.03 0.090
UF_rate 621 1.01 0.98, 1.03 0.668
Access_type 621


    AVF
— —
    AVG
0.80 0.50, 1.26 0.340
    TDC
0.80 0.65, 0.99 0.043
Dialysis_Vintage 621 0.98 0.93, 1.02 0.260
HF_score_Total 621 1.00 0.99, 1.01 0.870
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days Negative Binomial : time*group

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.80 0.60, 1.06 0.120
group



    BWH 253 — —
    MGH 368 0.63 0.47, 0.85 0.002
time * group 621


    2 * MGH 234 0.96 0.65, 1.43 0.847
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days Negative Binomial ： time*group+Age+Gender+Race_Group

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.79 0.60, 1.05 0.108
group



    BWH 253 — —
    MGH 368 0.65 0.48, 0.87 0.004
Age 621 1.0 0.99, 1.00 0.187
Gender



    Female 260 — —
    Male 361 1.00 0.82, 1.22 0.980
Race_Group



    Black 133 — —
    Others 116 0.98 0.72, 1.33 0.885
    White 372 0.94 0.73, 1.21 0.619
time * group 621


    2 * MGH 234 0.96 0.65, 1.43 0.837
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

180 days Negative Binomial ： time*group+ Race_Group + Gender+ UF_rate+Access_type+Dialysis_Vintage+HF_score_Total

Characteristic N IRR1 95% CI1 p-value
time



    1 243 — —
    2 378 0.81 0.61, 1.07 0.142
group



    BWH 253 — —
    MGH 368 0.65 0.48, 0.88 0.005
Race_Group



    Black 133 — —
    Others 116 0.93 0.68, 1.26 0.631
    White 372 0.90 0.70, 1.16 0.420
Gender



    Female 260 — —
    Male 361 1.00 0.82, 1.23 0.974
UF_rate 621 1.00 0.98, 1.03 0.692
Access_type



    AVF 365 — —
    AVG 34 0.93 0.58, 1.46 0.748
    TDC 222 0.82 0.65, 1.02 0.081
Dialysis_Vintage 621 0.96 0.91, 1.00 0.067
HF_score_Total 621 1.00 0.99, 1.01 0.830
time * group 621


    2 * MGH 234 0.95 0.64, 1.42 0.809
1 IRR = Incidence Rate Ratio, CI = Confidence Interval

Univariate coxph decongestion_time_days

Characteristic N HR1 95% CI1 p-value
time 621


    1
— —
    2
1.04 0.88, 1.22 0.664
group 621


    BWH
— —
    MGH
1.25 1.06, 1.47 0.007
Age 621 1.00 1.00, 1.01 0.546
Gender 621


    Female
— —
    Male
0.85 0.73, 1.00 0.050
Race_Group 621


    Black
— —
    Others
1.04 0.81, 1.33 0.783
    White
0.75 0.62, 0.92 0.006
UF_rate 621 1.04 1.02, 1.06 <0.001
Access_type 621


    AVF
— —
    AVG
0.97 0.68, 1.38 0.855
    TDC
0.69 0.58, 0.81 <0.001
Dialysis_Vintage 621 0.99 0.97, 1.02 0.615
HF_score_Total 621 0.99 0.98, 1.00 0.095
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days :time*group+Age+Gender+Race_Group

Characteristic HR1 95% CI1 p-value
time


    1 — —
    2 0.90 0.70, 1.16 0.424
group


    BWH — —
    MGH 1.10 0.85, 1.42 0.484
Age 1.00 1.00, 1.01 0.219
Gender


    Female — —
    Male 0.88 0.75, 1.04 0.134
Race_Group


    Black — —
    Others 0.97 0.75, 1.26 0.836
    White 0.70 0.57, 0.87 0.001
time * group


    2 * MGH 1.28 0.91, 1.79 0.154
1 HR = Hazard Ratio, CI = Confidence Interval

coxph decongestion_time_days :time*group+ Race_Group + Gender+ UF_rate+Access_type+Dialysis_Vintage+HF_score_Total

Characteristic HR1 95% CI1 p-value
time


    1 — —
    2 0.95 0.73, 1.22 0.669
group


    BWH — —
    MGH 1.19 0.91, 1.55 0.195
Race_Group


    Black — —
    Others 0.91 0.70, 1.18 0.479
    White 0.74 0.60, 0.91 0.004
Gender


    Female — —
    Male 0.89 0.75, 1.05 0.157
UF_rate 1.03 1.01, 1.05 0.001
Access_type


    AVF — —
    AVG 0.95 0.67, 1.36 0.781
    TDC 0.67 0.56, 0.81 <0.001
Dialysis_Vintage 0.98 0.95, 1.01 0.157
HF_score_Total 1.00 0.99, 1.01 0.502
time * group


    2 * MGH 1.18 0.85, 1.66 0.325
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate coxph time_1st_readmission_180

Characteristic N HR1 95% CI1 p-value
time 621


    1
— —
    2
0.92 0.74, 1.14 0.430
group 621


    BWH
— —
    MGH
0.65 0.53, 0.81 <0.001
Age 621 1.00 0.99, 1.01 0.706
Gender 621


    Female
— —
    Male
0.99 0.80, 1.22 0.915
Race_Group 621


    Black
— —
    Others
0.94 0.68, 1.30 0.706
    White
0.93 0.71, 1.20 0.568
UF_rate 621 1.01 0.98, 1.03 0.600
Access_type 621


    AVF
— —
    AVG
0.84 0.51, 1.37 0.485
    TDC
0.96 0.77, 1.19 0.698
Dialysis_Vintage 621 0.96 0.92, 1.01 0.118
HF_score_Total 621 1.00 0.99, 1.02 0.533
1 HR = Hazard Ratio, CI = Confidence Interval

coxph time_1st_readmission_180 :time*group+Age+Gender+Race_Group

Characteristic HR1 95% CI1 p-value
time


    1 — —
    2 0.98 0.72, 1.34 0.898
group


    BWH — —
    MGH 0.68 0.49, 0.95 0.025
Age 1.00 0.99, 1.01 0.947
Gender


    Female — —
    Male 0.99 0.80, 1.23 0.921
Race_Group


    Black — —
    Others 0.99 0.71, 1.38 0.950
    White 1.00 0.76, 1.31 >0.999
time * group


    2 * MGH 0.93 0.61, 1.44 0.754
1 HR = Hazard Ratio, CI = Confidence Interval

coxph time_1st_readmission_180 :time*group+ Race_Group + Gender+ UF_rate+Access_type+Dialysis_Vintage+HF_score_Total

Characteristic HR1 95% CI1 p-value
time


    1 — —
    2 0.99 0.72, 1.35 0.928
group


    BWH — —
    MGH 0.69 0.49, 0.97 0.034
Race_Group


    Black — —
    Others 0.98 0.70, 1.37 0.909
    White 1.00 0.77, 1.31 0.993
Gender


    Female — —
    Male 1.00 0.80, 1.25 0.990
UF_rate 1.01 0.99, 1.04 0.378
Access_type


    AVF — —
    AVG 0.92 0.55, 1.52 0.738
    TDC 0.96 0.75, 1.21 0.708
Dialysis_Vintage 0.95 0.91, 1.00 0.066
HF_score_Total 1.00 0.99, 1.01 0.984
time * group


    2 * MGH 0.90 0.58, 1.40 0.654
1 HR = Hazard Ratio, CI = Confidence Interval