Josh 2

add missing variables

function create competing risk

updated sub

#Side Effect #Hospitalization #Throm_2 #Throm_3

#aki_2 #aki_3

#anemia_2 #anemia_3

#1 Grade ≥ 2 Anemia z score

#2 Grade ≥ 3 Thrombocytopenia z score

#3 Grade ≥ 3 Creatinine Increased

#4 Hospitalization for platinum-associated AEs #5 Overall Hospitalization

#6 Mortality

#7 Hypokalemia_90days

#8 Hypomagnesemia_90days

#9 Hyponatremia_90days

#1-KM

competing risk models

Univariate Side Effect all	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_10	458	0.86	0.79, 0.95	0.002
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate Side Effect sarcopenia	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_10	158	0.86	0.74, 1.00	0.045
1 HR = Hazard Ratio, CI = Confidence Interval

Univariate Side Effect no_sarcopenia	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_10	300	0.89	0.78, 1.00	0.056
1 HR = Hazard Ratio, CI = Confidence Interval

side_effect baseline_cys_c_egfr_dose all

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.344    0.290   1.41   0.80, 2.49   0.24       
## baseline_cys_c_egfr_dose<50           0.604    0.317   1.83   0.98, 3.41   0.057      
## age                                   -0.007   0.010   0.99   0.97, 1.01   0.50       
## sex                                   -0.492   0.215   0.61   0.40, 0.93   0.022      
## ecog_score2                           0.346    0.237   1.41   0.89, 2.25   0.14       
## ecog_score3                           0.953    0.376   2.59   1.24, 5.42   0.011      
## ecog_score4                           0.865    0.647   2.37   0.67, 8.45   0.18

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.344    0.308   1.41   0.77, 2.58   0.26       
## baseline_cys_c_egfr_dose<50           0.603    0.345   1.83   0.93, 3.59   0.080      
## baseline_cre_egfr                     0.000    0.007   1.00   0.99, 1.01   >0.99      
## age                                   -0.007   0.011   0.99   0.97, 1.01   0.55       
## sex                                   -0.493   0.218   0.61   0.40, 0.94   0.024      
## ecog_score2                           0.346    0.237   1.41   0.89, 2.25   0.14       
## ecog_score3                           0.953    0.378   2.59   1.24, 5.45   0.012      
## ecog_score4                           0.865    0.647   2.38   0.67, 8.45   0.18

side_effect baseline_cys_c_egfr_dose_new all

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   0.203    0.443   1.23   0.51, 2.92   0.65       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.344    0.290   1.41   0.80, 2.49   0.23       
## baseline_cys_c_egfr_dose_new<40           0.898    0.351   2.46   1.23, 4.89   0.011      
## age                                       -0.006   0.010   0.99   0.97, 1.01   0.51       
## sex                                       -0.535   0.217   0.59   0.38, 0.90   0.014      
## ecog_score2                               0.320    0.237   1.38   0.86, 2.19   0.18       
## ecog_score3                               0.969    0.376   2.64   1.26, 5.51   0.010      
## ecog_score4                               0.799    0.688   2.22   0.58, 8.56   0.25

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   0.271    0.450   1.31   0.54, 3.17   0.55       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.413    0.310   1.51   0.82, 2.77   0.18       
## baseline_cys_c_egfr_dose_new<40           1.12     0.439   3.07   1.30, 7.24   0.011      
## baseline_cre_egfr                         0.006    0.008   1.01   0.99, 1.02   0.44       
## age                                       -0.003   0.011   1.00   0.98, 1.02   0.79       
## sex                                       -0.522   0.218   0.59   0.39, 0.91   0.017      
## ecog_score2                               0.285    0.238   1.33   0.83, 2.12   0.23       
## ecog_score3                               0.934    0.374   2.55   1.22, 5.29   0.012      
## ecog_score4                               0.747    0.662   2.11   0.58, 7.72   0.26

side_effect baseline_cys_c_egfr_group all

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            0.974    0.423   2.65   1.15, 6.07   0.021      
## baseline_cys_c_egfr_group>=45 <=59.99   0.287    0.370   1.33   0.65, 2.75   0.44       
## baseline_cys_c_egfr_group>=60 <=89.99   0.096    0.312   1.10   0.60, 2.03   0.76       
## age                                     -0.009   0.010   0.99   0.97, 1.01   0.39       
## sex                                     -0.542   0.220   0.58   0.38, 0.89   0.014      
## ecog_score2                             0.355    0.239   1.43   0.89, 2.28   0.14       
## ecog_score3                             0.904    0.388   2.47   1.15, 5.28   0.020      
## ecog_score4                             0.718    0.615   2.05   0.61, 6.84   0.24

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            1.21     0.512   3.34   1.22, 9.13   0.019      
## baseline_cys_c_egfr_group>=45 <=59.99   0.394    0.400   1.48   0.68, 3.24   0.32       
## baseline_cys_c_egfr_group>=60 <=89.99   0.148    0.319   1.16   0.62, 2.17   0.64       
## baseline_cre_egfr                       0.006    0.008   1.01   0.99, 1.02   0.44       
## age                                     -0.006   0.011   0.99   0.97, 1.02   0.60       
## sex                                     -0.526   0.221   0.59   0.38, 0.91   0.017      
## ecog_score2                             0.326    0.238   1.39   0.87, 2.21   0.17       
## ecog_score3                             0.849    0.394   2.34   1.08, 5.06   0.031      
## ecog_score4                             0.623    0.593   1.86   0.58, 5.97   0.29

cox death baseline_cys_c_egfr_group all

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	458
>=90		—	—
<45		6.47	1.05, 39.9	0.044
>=45 <=59.99		2.92	0.48, 17.7	0.244
>=60 <=89.99		1.46	0.27, 7.74	0.658
age	458	0.98	0.94, 1.03	0.394
sex	458	0.41	0.17, 0.99	0.048
ecog_score	458
1		—	—
2		3.33	0.94, 11.8	0.063
3		9.18	2.09, 40.3	0.003
4		6.56	0.64, 67.2	0.113
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	458
>=90		—	—
<45		25.0	2.78, 225	0.004
>=45 <=59.99		5.37	0.81, 35.4	0.081
>=60 <=89.99		1.89	0.35, 10.3	0.462
baseline_cre_egfr	458	1.04	1.00, 1.08	0.035
age	458	1.00	0.95, 1.04	0.888
sex	458	0.45	0.18, 1.09	0.077
ecog_score	458
1		—	—
2		2.79	0.78, 9.96	0.113
3		6.76	1.50, 30.4	0.013
4		3.30	0.28, 38.4	0.340
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose all

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	458
>=60		—	—
50 - 59.99		1.02	0.20, 5.12	0.984
<50		5.67	1.87, 17.2	0.002
age	458	0.98	0.93, 1.02	0.286
sex	458	0.41	0.17, 1.00	0.050
ecog_score	458
1		—	—
2		3.54	1.00, 12.6	0.050
3		8.84	2.01, 38.9	0.004
4		7.01	0.69, 71.0	0.099
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	458
>=60		—	—
50 - 59.99		1.51	0.29, 8.00	0.625
<50		12.7	3.25, 50.0	<0.001
baseline_cre_egfr	458	1.03	1.00, 1.07	0.047
age	458	0.99	0.94, 1.03	0.626
sex	458	0.49	0.20, 1.21	0.120
ecog_score	458
1		—	—
2		3.00	0.84, 10.7	0.092
3		6.90	1.54, 30.9	0.012
4		4.35	0.40, 47.1	0.226
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose all

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	458
>=60		—	—
40 - 49.99		7.34	2.15, 25.0	0.001
50 - 59.99		1.02	0.20, 5.17	0.976
<40		4.38	1.20, 16.0	0.026
age	458	0.98	0.93, 1.02	0.269
sex	458	0.43	0.18, 1.05	0.065
ecog_score	458
1		—	—
2		3.65	1.03, 13.0	0.045
3		8.86	2.01, 38.9	0.004
4		7.89	0.77, 81.1	0.082
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	458
>=60		—	—
40 - 49.99		12.4	3.09, 50.1	<0.001
50 - 59.99		1.61	0.30, 8.61	0.581
<40		18.1	2.66, 123	0.003
baseline_cre_egfr	458	1.04	1.00, 1.08	0.058
age	458	0.99	0.95, 1.04	0.725
sex	458	0.49	0.20, 1.20	0.117
ecog_score	458
1		—	—
2		2.86	0.79, 10.4	0.110
3		6.73	1.50, 30.2	0.013
4		3.78	0.33, 43.1	0.284
1 HR = Hazard Ratio, CI = Confidence Interval

side_effect baseline_cys_c_egfr_dose final_master_z_score_sarcopenia

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.247    0.429   1.28   0.55, 2.97   0.57       
## baseline_cys_c_egfr_dose<50           0.413    0.451   1.51   0.62, 3.66   0.36       
## age                                   -0.003   0.014   1.00   0.97, 1.03   0.85       
## sex                                   -0.752   0.435   0.47   0.20, 1.10   0.083      
## ecog_score                            0.448    0.196   1.57   1.07, 2.30   0.022

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.303    0.443   1.35   0.57, 3.23   0.49       
## baseline_cys_c_egfr_dose<50           0.537    0.473   1.71   0.68, 4.32   0.26       
## baseline_cre_egfr                     0.005    0.011   1.01   0.98, 1.03   0.63       
## age                                   0.000    0.015   1.00   0.97, 1.03   0.98       
## sex                                   -0.730   0.440   0.48   0.20, 1.14   0.10       
## ecog_score                            0.448    0.196   1.56   1.06, 2.30   0.023

side_effect baseline_cys_c_egfr_dose_new final_master_z_score_sarcopenia

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   -0.327   0.732   0.72   0.17, 3.03   0.66       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.224    0.424   1.25   0.54, 2.87   0.60       
## baseline_cys_c_egfr_dose_new<40           0.839    0.454   2.31   0.95, 5.64   0.065      
## age                                       0.001    0.014   1.00   0.97, 1.03   0.93       
## sex                                       -0.881   0.433   0.41   0.18, 0.97   0.042      
## ecog_score                                0.376    0.196   1.46   0.99, 2.14   0.056

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   -0.142   0.731   0.87   0.21, 3.64   0.85       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.387    0.436   1.47   0.63, 3.46   0.38       
## baseline_cys_c_egfr_dose_new<40           1.41     0.578   4.09   1.32, 12.7   0.015      
## baseline_cre_egfr                         0.016    0.012   1.02   0.99, 1.04   0.17       
## age                                       0.009    0.016   1.01   0.98, 1.04   0.60       
## sex                                       -0.847   0.435   0.43   0.18, 1.01   0.052      
## ecog_score                                0.340    0.199   1.40   0.95, 2.07   0.088

side_effect baseline_cys_c_egfr_group final_master_z_score_sarcopenia

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            0.930    0.669   2.53   0.68, 9.41   0.17       
## baseline_cys_c_egfr_group>=45 <=59.99   0.044    0.663   1.04   0.29, 3.83   0.95       
## baseline_cys_c_egfr_group>=60 <=89.99   0.124    0.564   1.13   0.37, 3.42   0.83       
## age                                     -0.003   0.014   1.00   0.97, 1.02   0.82       
## sex                                     -0.849   0.442   0.43   0.18, 1.02   0.055      
## ecog_score                              0.408    0.193   1.50   1.03, 2.20   0.035

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            1.49     0.755   4.42   1.01, 19.4   0.049      
## baseline_cys_c_egfr_group>=45 <=59.99   0.290    0.682   1.34   0.35, 5.09   0.67       
## baseline_cys_c_egfr_group>=60 <=89.99   0.219    0.569   1.24   0.41, 3.80   0.70       
## baseline_cre_egfr                       0.016    0.012   1.02   0.99, 1.04   0.17       
## age                                     0.003    0.016   1.00   0.97, 1.04   0.84       
## sex                                     -0.791   0.446   0.45   0.19, 1.09   0.076      
## ecog_score                              0.372    0.204   1.45   0.97, 2.16   0.068

cox death baseline_cys_c_egfr_group final_master_z_score_sarcopenia

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	158
>=90		—	—
<45		2.11	0.21, 21.6	0.529
>=45 <=59.99		1.02	0.09, 11.5	0.989
>=60 <=89.99		0.62	0.06, 6.44	0.693
age	158	1.04	0.97, 1.11	0.295
sex	158	0.49	0.10, 2.33	0.368
ecog_score	158	1.74	0.89, 3.41	0.105
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	158
>=90		—	—
<45		4.64	0.32, 68.0	0.262
>=45 <=59.99		1.42	0.12, 17.3	0.782
>=60 <=89.99		0.69	0.06, 7.32	0.758
baseline_cre_egfr	158	1.03	0.98, 1.07	0.245
age	158	1.05	0.98, 1.13	0.187
sex	158	0.54	0.11, 2.63	0.448
ecog_score	158	1.74	0.86, 3.55	0.125
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose final_master_z_score_sarcopenia

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	158
>=60		—	—
50 - 59.99		1.06	0.18, 6.26	0.948
<50		3.18	0.83, 12.2	0.092
age	158	1.03	0.96, 1.10	0.433
sex	158	0.54	0.12, 2.55	0.438
ecog_score	158	1.85	0.95, 3.61	0.072
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	158
>=60		—	—
50 - 59.99		1.36	0.22, 8.32	0.738
<50		5.39	1.07, 27.1	0.041
baseline_cre_egfr	158	1.02	0.98, 1.06	0.270
age	158	1.03	0.97, 1.10	0.342
sex	158	0.63	0.13, 3.08	0.570
ecog_score	158	1.88	0.93, 3.79	0.077
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose final_master_z_score_sarcopenia

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	158
>=60		—	—
40 - 49.99		6.10	1.29, 28.8	0.022
50 - 59.99		1.08	0.18, 6.58	0.932
<40		1.59	0.26, 9.71	0.615
age	158	1.02	0.95, 1.09	0.632
sex	158	0.72	0.14, 3.67	0.693
ecog_score	158	2.25	1.08, 4.68	0.030
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	158
>=60		—	—
40 - 49.99		6.85	1.35, 34.7	0.020
50 - 59.99		1.22	0.19, 7.81	0.832
<40		2.26	0.22, 23.0	0.489
baseline_cre_egfr	158	1.01	0.97, 1.05	0.641
age	158	1.02	0.95, 1.09	0.545
sex	158	0.73	0.14, 3.72	0.708
ecog_score	158	2.21	1.04, 4.70	0.039
1 HR = Hazard Ratio, CI = Confidence Interval

side_effect baseline_cys_c_egfr_dose final_master_z_score_no_sarcopenia

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.275    0.427   1.32   0.57, 3.04   0.52       
## baseline_cys_c_egfr_dose<50           0.766    0.421   2.15   0.94, 4.91   0.069      
## age                                   -0.012   0.013   0.99   0.96, 1.01   0.37       
## sex                                   -0.099   0.315   0.91   0.49, 1.68   0.75       
## ecog_score                            0.301    0.221   1.35   0.88, 2.08   0.17

## 
## Variable                              Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose 50 - 59.99   0.231    0.457   1.26   0.51, 3.09   0.61       
## baseline_cys_c_egfr_dose<50           0.672    0.494   1.96   0.74, 5.16   0.17       
## baseline_cre_egfr                     -0.004   0.011   1.00   0.98, 1.02   0.71       
## age                                   -0.014   0.015   0.99   0.96, 1.02   0.34       
## sex                                   -0.118   0.325   0.89   0.47, 1.68   0.72       
## ecog_score                            0.320    0.229   1.38   0.88, 2.16   0.16

side_effect baseline_cys_c_egfr_dose_new final_master_z_score_no_sarcopenia

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   0.627    0.528   1.87   0.66, 5.27   0.24       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.277    0.427   1.32   0.57, 3.05   0.52       
## baseline_cys_c_egfr_dose_new<40           0.882    0.510   2.42   0.89, 6.57   0.084      
## age                                       -0.012   0.013   0.99   0.96, 1.01   0.36       
## sex                                       -0.113   0.318   0.89   0.48, 1.67   0.72       
## ecog_score                                0.306    0.225   1.36   0.87, 2.11   0.17

## 
## Variable                                  Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_dose_new 40 - 49.99   0.593    0.552   1.81   0.61, 5.34   0.28       
## baseline_cys_c_egfr_dose_new 50 - 59.99   0.248    0.465   1.28   0.52, 3.18   0.59       
## baseline_cys_c_egfr_dose_new<40           0.793    0.659   2.21   0.61, 8.04   0.23       
## baseline_cre_egfr                         -0.003   0.012   1.00   0.97, 1.02   0.82       
## age                                       -0.014   0.015   0.99   0.96, 1.02   0.36       
## sex                                       -0.122   0.325   0.88   0.47, 1.67   0.71       
## ecog_score                                0.317    0.228   1.37   0.88, 2.15   0.16

side_effect baseline_cys_c_egfr_group final_master_z_score_no_sarcopenia

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            0.824    0.544   2.28   0.79, 6.62   0.13       
## baseline_cys_c_egfr_group>=45 <=59.99   0.363    0.461   1.44   0.58, 3.55   0.43       
## baseline_cys_c_egfr_group>=60 <=89.99   0.009    0.380   1.01   0.48, 2.13   0.98       
## age                                     -0.012   0.014   0.99   0.96, 1.02   0.40       
## sex                                     -0.130   0.315   0.88   0.47, 1.63   0.68       
## ecog_score                              0.310    0.217   1.36   0.89, 2.08   0.15

## 
## Variable                                Coef     SE      HR     95% CI       p-value    
## baseline_cys_c_egfr_group<45            0.701    0.671   2.02   0.54, 7.51   0.30       
## baseline_cys_c_egfr_group>=45 <=59.99   0.303    0.514   1.35   0.49, 3.70   0.56       
## baseline_cys_c_egfr_group>=60 <=89.99   -0.021   0.388   0.98   0.46, 2.10   0.96       
## baseline_cre_egfr                       -0.003   0.011   1.00   0.97, 1.02   0.76       
## age                                     -0.013   0.015   0.99   0.96, 1.02   0.38       
## sex                                     -0.141   0.321   0.87   0.46, 1.63   0.66       
## ecog_score                              0.329    0.225   1.39   0.89, 2.16   0.14

cox death baseline_cys_c_egfr_group final_master_z_score_no_sarcopenia

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	300
>=90		—	—
<45		14.5	0.61, 344	0.098
>=45 <=59.99		7.20	0.41, 128	0.178
>=60 <=89.99		2.86	0.24, 34.3	0.406
age	300	0.93	0.87, 1.00	0.041
sex	300	0.55	0.12, 2.58	0.452
ecog_score	300	3.24	1.36, 7.70	0.008
1 HR = Hazard Ratio, CI = Confidence Interval

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_group	300
>=90		—	—
<45		60.3	1.39, 2,624	0.033
>=45 <=59.99		14.9	0.74, 300	0.078
>=60 <=89.99		4.00	0.33, 49.0	0.279
baseline_cre_egfr	300	1.04	0.98, 1.10	0.160
age	300	0.95	0.88, 1.02	0.160
sex	300	0.62	0.13, 2.85	0.537
ecog_score	300	2.25	0.84, 6.01	0.105
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose final_master_z_score_no_sarcopenia

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 1 ; coefficient may be infinite.

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	300
>=60		—	—
50 - 59.99		0.00	0.00, Inf	0.998
<50		10.1	1.38, 73.8	0.023
age	300	0.93	0.88, 1.0	0.033
sex	300	0.53	0.12, 2.35	0.406
ecog_score	300	2.95	1.28, 6.78	0.011
1 HR = Hazard Ratio, CI = Confidence Interval

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 1 ; coefficient may be infinite.

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose	300
>=60		—	—
50 - 59.99		0.00	0.00, Inf	0.998
<50		32.9	2.47, 438	0.008
baseline_cre_egfr	300	1.04	0.99, 1.10	0.124
age	300	0.95	0.89, 1.02	0.158
sex	300	0.75	0.17, 3.30	0.705
ecog_score	300	2.05	0.80, 5.24	0.134
1 HR = Hazard Ratio, CI = Confidence Interval

cox death baseline_cys_c_egfr_dose final_master_z_score_no_sarcopenia

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	300
>=60		—	—
40 - 49.99		8.22	0.82, 82.2	0.073
50 - 59.99		0.00	0.00, Inf	0.999
<40		11.6	1.42, 95.2	0.022
age	300	0.93	0.88, 1.00	0.036
sex	300	0.50	0.11, 2.31	0.377
ecog_score	300	2.97	1.28, 6.85	0.011
1 HR = Hazard Ratio, CI = Confidence Interval

## Warning in coxph.fit(X, Y, istrat, offset, init, control, weights = weights, :
## Loglik converged before variable 2 ; coefficient may be infinite.

Characteristic	N	HR1	95% CI1	p-value
baseline_cys_c_egfr_dose_new	300
>=60		—	—
40 - 49.99		30.4	1.82, 506	0.017
50 - 59.99		0.00	0.00, Inf	0.999
<40		552	11.0, 27,817	0.002
baseline_cre_egfr	300	1.11	1.02, 1.21	0.022
age	300	0.98	0.91, 1.06	0.628
sex	300	0.66	0.15, 2.98	0.593
ecog_score	300	1.91	0.83, 4.36	0.126
1 HR = Hazard Ratio, CI = Confidence Interval