Explore the molecular insights from the research paper by Quaade et al. (2025)
Key Findings
Shared Molecular Endotype: CHE has a common underlying molecular signature across different subtypes.
Dominant Pathways: The inflammation is characterized by strong $T_{H}1$ and $T_{H}2$ pathway activation.
Potential Targets: Key upstream regulators like IFN-γ, IL-4, and IL-1β are highlighted as potential therapeutic targets.
DEG Search & Visualization
Study Design & Methods
Study Population: The study included 96 adult patients with CHE and/or AD, and 32 healthy controls. The primary analysis focused on 54 lesional CHE palm samples and 16 healthy palm samples.
Sample Collection: 3mm skin punch biopsies were collected from palms, dorsa, and arms. Samples were taken from the most affected areas for patients and from matching anatomic sites for controls.
Molecular Analysis: RNA sequencing was performed on the biopsy samples to study the transcriptome. Differentially expressed genes (DEGs) were identified, and Ingenuity Pathway Analysis (IPA) was used to analyze pathways and predict upstream regulators.