FORCE Data Summary
LCC Lab Community Team & April Vang
2025-08-26
There are 2 patients that did not consent and removed.
Note: Of 1256 total survey respondents, 847 had complete data on 12 key variables (Consent, received germline genetic testing, genetic diagnosis, age at diagnosis (germline mutation), genetic test result, sex at birth, age range, cancer diagnosis, family history of stomach cancer, any gastric lesion, race/ethnicity, anti-acid medication/proton pump inhibitors). We proceed our analysis with n=847 patients.
Demographics summary: Participants are 95% female, 91% Non-Hispanic White, and 73% between ages 40-69y,
Figures
Self-reported cancer diagnosis. Note patients may indicate more than one cancer.
Self-reported genes. Note patients may report more than one gene.
Self-reported gastric lesions. Note patients may report more than one
lesion.
Table 1. Risk factors by no cancer versus stomach cancer
| Characteristic | Overall N = 4091 |
No N = 3741 |
Yes N = 351 |
p-value |
|---|---|---|---|---|
| Fam_Hist_Stomach_Cancer | 0.0382 | |||
| Don't know | 64 (16%) | 58 (16%) | 6 (17%) | |
| No | 239 (58%) | 225 (60%) | 14 (40%) | |
| Yes | 106 (26%) | 91 (24%) | 15 (43%) | |
| Any_Gastric_Lesion | 0.0042 | |||
| No | 200 (49%) | 191 (51%) | 9 (26%) | |
| Yes | 209 (51%) | 183 (49%) | 26 (74%) | |
| H_pylori | 0.0033 | |||
| No | 384 (94%) | 356 (95%) | 28 (80%) | |
| Yes | 25 (6.1%) | 18 (4.8%) | 7 (20%) | |
| HR | <0.0012 | |||
| No | 94 (23%) | 76 (20%) | 18 (51%) | |
| Yes | 315 (77%) | 298 (80%) | 17 (49%) | |
| Lynch | 0.82 | |||
| No | 343 (84%) | 313 (84%) | 30 (86%) | |
| Yes | 66 (16%) | 61 (16%) | 5 (14%) | |
| Anti_acid_ever | 0.62 | |||
| No | 168 (41%) | 155 (41%) | 13 (37%) | |
| Yes | 241 (59%) | 219 (59%) | 22 (63%) | |
| Anti_acid_time | 0.0013 | |||
| No | 168 (41%) | 155 (41%) | 13 (38%) | |
| Daily | 105 (26%) | 88 (24%) | 17 (50%) | |
| 1-4 times weekly | 57 (14%) | 57 (15%) | 0 (0%) | |
| 1-4 times monthly | 21 (5.1%) | 20 (5.3%) | 1 (2.9%) | |
| 1-4 times in past 6 months | 48 (12%) | 47 (13%) | 1 (2.9%) | |
| Other/As needed | 9 (2.2%) | 7 (1.9%) | 2 (5.9%) | |
| Missing | 1 | 0 | 1 | |
| 1 n (%) | ||||
| 2 Pearson’s Chi-squared test | ||||
| 3 Fisher’s exact test | ||||
Table 1 interpretation:
Participants with a family history of stomach cancer (43% vs. 24%, p=0.038), any gastric lesion (74% vs. 49%, p=0.0004), H. pylori (20% vs. 4.8%, p=0.003), or use anti acid medications daily (50% vs. 24%, p=0.001) are more likely to have stomach cancer.
Participants with HR genes (49% vs. 80%, p<0.0001) are less likely to have stomach cancer.
There is no association between Lynch genes and stomach cancer (p=0.800).
Any grastric lesion includes any of the following:
Helicobacter Pylori (H. pylori)
Gastritis
Gastric Ulcer
Gastro-esophageal reflux (GERD)
Intestinal Metaplasia
Barrett’s Esophagus
Pernicious Anemia
HR genes: ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, PALB2, RAD51C, RAD51D, NBN
Lynch genes: MLH1, MSH2, MSH6, PMS2, EPCAM