| Associations of the Biological Age Accelerations With the Risk of HF | |||||
| Model | Quartile | Cases/Person-Years | Incidence Rate, per 1,000 Person-Years | HR (95% CI) | P Value |
|---|---|---|---|---|---|
| PhenoAge acceleration | |||||
| Crude | Q1 | 257/186823.2 | 1.37 | Reference | - |
| Crude | Q2 | 372/186082.8 | 2.00 | 1.30(1.11 - 1.53) | 0.0012 |
| Crude | Q3 | 747/189370.7 | 3.94 | 2.06(1.78 - 2.39) | <0.001 |
| Model 1 | Q1 | 257/186823.2 | 1.37 | Reference | - |
| Model 1 | Q2 | 372/186082.8 | 2.00 | 1.30(1.11 - 1.53) | 0.0012 |
| Model 1 | Q3 | 747/189370.7 | 3.94 | 2.06(1.78 - 2.39) | <0.001 |
| Model 2 | Q1 | 257/186823.2 | 1.37 | Reference | - |
| Model 2 | Q2 | 372/186082.8 | 2.00 | 1.30(1.11 - 1.53) | 0.0012 |
| Model 2 | Q3 | 747/189370.7 | 3.94 | 2.06(1.78 - 2.39) | <0.001 |
| Model 3 | Q1 | 257/186823.2 | 1.37 | Reference | - |
| Model 3 | Q2 | 372/186082.8 | 2.00 | 1.30(1.11 - 1.53) | 0.0012 |
| Model 3 | Q3 | 747/189370.7 | 3.94 | 2.06(1.78 - 2.39) | <0.001 |
| KDM-BA acceleration | |||||
| Crude | Q1 | 283/186841.2 | 1.51 | Reference | - |
| Crude | Q2 | 373/186076.3 | 2.00 | 1.18(1.01 - 1.37) | 0.042 |
| Crude | Q3 | 720/189359.1 | 3.80 | 1.95(1.69 - 2.26) | <0.001 |
| Model 1 | Q1 | 283/186841.2 | 1.51 | Reference | - |
| Model 1 | Q2 | 373/186076.3 | 2.00 | 1.18(1.01 - 1.37) | 0.042 |
| Model 1 | Q3 | 720/189359.1 | 3.80 | 1.95(1.69 - 2.26) | <0.001 |
| Model 2 | Q1 | 283/186841.2 | 1.51 | Reference | - |
| Model 2 | Q2 | 373/186076.3 | 2.00 | 1.18(1.01 - 1.37) | 0.042 |
| Model 2 | Q3 | 720/189359.1 | 3.80 | 1.95(1.69 - 2.26) | <0.001 |
| Model 3 | Q1 | 283/186841.2 | 1.51 | Reference | - |
| Model 3 | Q2 | 373/186076.3 | 2.00 | 1.18(1.01 - 1.37) | 0.042 |
| Model 3 | Q3 | 720/189359.1 | 3.80 | 1.95(1.69 - 2.26) | <0.001 |